Page last updated: 2024-08-07 18:26:40
Solute carrier family 22 member 6
A solute carrier family 22 member 6 that is encoded in the genome of rat. [OMA:O35956, PRO:DNx]
Synonyms
Organic anion transporter 1;
rOAT1;
renal organic anion transporter 1;
rROAT1
Research
Bioassay Publications (20)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (35.00) | 18.2507 |
| 2000's | 12 (60.00) | 29.6817 |
| 2010's | 1 (5.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (47)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| salicylic acid | Rattus norvegicus (Norway rat) | Ki | 670.5000 | 2 | 2 |
| hippuric acid | Rattus norvegicus (Norway rat) | Ki | 27.5000 | 1 | 1 |
| acetaminophen | Rattus norvegicus (Norway rat) | Ki | 2,099.0000 | 1 | 1 |
| acetazolamide | Rattus norvegicus (Norway rat) | Ki | 1,100.0000 | 1 | 1 |
| aspirin | Rattus norvegicus (Norway rat) | Ki | 428.0000 | 1 | 1 |
| bumetanide | Rattus norvegicus (Norway rat) | Ki | 5.5000 | 1 | 1 |
| chlorpropamide | Rattus norvegicus (Norway rat) | Ki | 39.5000 | 2 | 2 |
| cimetidine | Rattus norvegicus (Norway rat) | IC50 | 2,000.0000 | 1 | 1 |
| cimetidine | Rattus norvegicus (Norway rat) | Ki | 1,000.0000 | 1 | 1 |
| etodolac | Rattus norvegicus (Norway rat) | Ki | 100.0000 | 1 | 1 |
| furosemide | Rattus norvegicus (Norway rat) | Ki | 9.5000 | 1 | 1 |
| glyburide | Rattus norvegicus (Norway rat) | Ki | 1.6000 | 1 | 1 |
| hydrochlorothiazide | Rattus norvegicus (Norway rat) | Ki | 150.0000 | 1 | 1 |
| ibuprofen | Rattus norvegicus (Norway rat) | Ki | 3.5000 | 1 | 1 |
| indomethacin | Rattus norvegicus (Norway rat) | Ki | 7.1000 | 2 | 2 |
| ketoprofen | Rattus norvegicus (Norway rat) | IC50 | 0.5000 | 1 | 1 |
| oxyphenbutazone | Rattus norvegicus (Norway rat) | Ki | 32.0000 | 1 | 1 |
| phenacetin | Rattus norvegicus (Norway rat) | Ki | 488.0000 | 1 | 1 |
| probenecid | Rattus norvegicus (Norway rat) | Ki | 23.4000 | 2 | 2 |
| tolbutamide | Rattus norvegicus (Norway rat) | Ki | 55.5000 | 2 | 2 |
| cephaloridine | Rattus norvegicus (Norway rat) | Ki | 1,825.0000 | 2 | 2 |
| penicillin g | Rattus norvegicus (Norway rat) | Ki | 1,049.0000 | 2 | 2 |
| cephalothin | Rattus norvegicus (Norway rat) | Ki | 410.0000 | 2 | 2 |
| taurocholic acid | Rattus norvegicus (Norway rat) | Ki | 2,770.0000 | 1 | 1 |
| salicylurate | Rattus norvegicus (Norway rat) | Ki | 11.0000 | 2 | 2 |
| acetylcysteine | Rattus norvegicus (Norway rat) | Ki | 2,000.0000 | 1 | 1 |
| carbenicillin | Rattus norvegicus (Norway rat) | Ki | 500.0000 | 1 | 1 |
| cephalexin | Rattus norvegicus (Norway rat) | IC50 | 2,000.0000 | 1 | 1 |
| cephalexin | Rattus norvegicus (Norway rat) | Ki | 2,310.0000 | 1 | 1 |
| cefazolin | Rattus norvegicus (Norway rat) | Ki | 505.0000 | 2 | 2 |
| cefotiam | Rattus norvegicus (Norway rat) | IC50 | 718.0000 | 1 | 1 |
| cefoperazone | Rattus norvegicus (Norway rat) | IC50 | 298.0000 | 1 | 1 |
| cefoperazone | Rattus norvegicus (Norway rat) | Ki | 480.0000 | 1 | 1 |
| cefadroxil anhydrous | Rattus norvegicus (Norway rat) | IC50 | 2,000.0000 | 1 | 1 |
| pravastatin | Rattus norvegicus (Norway rat) | Ki | 601.0000 | 2 | 2 |
| dibromosulphthalein | Rattus norvegicus (Norway rat) | Ki | 2.7400 | 1 | 1 |
| naproxen | Rattus norvegicus (Norway rat) | Ki | 2.0000 | 1 | 1 |
| cefamandole | Rattus norvegicus (Norway rat) | IC50 | 450.0000 | 1 | 1 |
| estradiol-17 beta-glucuronide | Rattus norvegicus (Norway rat) | Ki | 300.0000 | 2 | 2 |
| nateglinide | Rattus norvegicus (Norway rat) | Ki | 9.2000 | 2 | 2 |
| ceftriaxone | Rattus norvegicus (Norway rat) | IC50 | 840.0000 | 1 | 1 |
| cefotaxime | Rattus norvegicus (Norway rat) | IC50 | 2,000.0000 | 1 | 1 |
| cilastatin | Rattus norvegicus (Norway rat) | IC50 | 2,387.0000 | 1 | 1 |
| piroxicam | Rattus norvegicus (Norway rat) | Ki | 52.0000 | 1 | 1 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| hippuric acid | Rattus norvegicus (Norway rat) | Km | 28.0000 | 1 | 1 |
| p-aminohippuric acid | Rattus norvegicus (Norway rat) | Km | 48.7200 | 5 | 5 |
| zidovudine | Rattus norvegicus (Norway rat) | Km | 68.0000 | 1 | 1 |
| adefovir | Rattus norvegicus (Norway rat) | Km | 270.0000 | 1 | 1 |
| cidofovir anhydrous | Rattus norvegicus (Norway rat) | Km | 238.0000 | 1 | 1 |
| ochratoxin a | Rattus norvegicus (Norway rat) | Km | 1.3350 | 2 | 2 |
| acyclovir | Rattus norvegicus (Norway rat) | Km | 242.0000 | 1 | 1 |