Proteins > Solute carrier family 22 member 6
Page last updated: 2024-08-07 18:26:40
Solute carrier family 22 member 6
A solute carrier family 22 member 6 that is encoded in the genome of rat. [OMA:O35956, PRO:DNx]
Synonyms
Organic anion transporter 1;
rOAT1;
renal organic anion transporter 1;
rROAT1
Research
Bioassay Publications (20)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (35.00) | 18.2507 |
| 2000's | 12 (60.00) | 29.6817 |
| 2010's | 1 (5.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (47)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| salicylic acid | Rattus norvegicus (Norway rat) | Ki | 670.5000 | 2 | 2 |
| hippuric acid | Rattus norvegicus (Norway rat) | Ki | 27.5000 | 1 | 1 |
| acetaminophen | Rattus norvegicus (Norway rat) | Ki | 2,099.0000 | 1 | 1 |
| acetazolamide | Rattus norvegicus (Norway rat) | Ki | 1,100.0000 | 1 | 1 |
| aspirin | Rattus norvegicus (Norway rat) | Ki | 428.0000 | 1 | 1 |
| bumetanide | Rattus norvegicus (Norway rat) | Ki | 5.5000 | 1 | 1 |
| chlorpropamide | Rattus norvegicus (Norway rat) | Ki | 39.5000 | 2 | 2 |
| cimetidine | Rattus norvegicus (Norway rat) | IC50 | 2,000.0000 | 1 | 1 |
| cimetidine | Rattus norvegicus (Norway rat) | Ki | 1,000.0000 | 1 | 1 |
| etodolac | Rattus norvegicus (Norway rat) | Ki | 100.0000 | 1 | 1 |
| furosemide | Rattus norvegicus (Norway rat) | Ki | 9.5000 | 1 | 1 |
| glyburide | Rattus norvegicus (Norway rat) | Ki | 1.6000 | 1 | 1 |
| hydrochlorothiazide | Rattus norvegicus (Norway rat) | Ki | 150.0000 | 1 | 1 |
| ibuprofen | Rattus norvegicus (Norway rat) | Ki | 3.5000 | 1 | 1 |
| indomethacin | Rattus norvegicus (Norway rat) | Ki | 7.1000 | 2 | 2 |
| ketoprofen | Rattus norvegicus (Norway rat) | IC50 | 0.5000 | 1 | 1 |
| oxyphenbutazone | Rattus norvegicus (Norway rat) | Ki | 32.0000 | 1 | 1 |
| phenacetin | Rattus norvegicus (Norway rat) | Ki | 488.0000 | 1 | 1 |
| probenecid | Rattus norvegicus (Norway rat) | Ki | 23.4000 | 2 | 2 |
| tolbutamide | Rattus norvegicus (Norway rat) | Ki | 55.5000 | 2 | 2 |
| cephaloridine | Rattus norvegicus (Norway rat) | Ki | 1,825.0000 | 2 | 2 |
| penicillin g | Rattus norvegicus (Norway rat) | Ki | 1,049.0000 | 2 | 2 |
| cephalothin | Rattus norvegicus (Norway rat) | Ki | 410.0000 | 2 | 2 |
| taurocholic acid | Rattus norvegicus (Norway rat) | Ki | 2,770.0000 | 1 | 1 |
| salicylurate | Rattus norvegicus (Norway rat) | Ki | 11.0000 | 2 | 2 |
| acetylcysteine | Rattus norvegicus (Norway rat) | Ki | 2,000.0000 | 1 | 1 |
| carbenicillin | Rattus norvegicus (Norway rat) | Ki | 500.0000 | 1 | 1 |
| cephalexin | Rattus norvegicus (Norway rat) | IC50 | 2,000.0000 | 1 | 1 |
| cephalexin | Rattus norvegicus (Norway rat) | Ki | 2,310.0000 | 1 | 1 |
| cefazolin | Rattus norvegicus (Norway rat) | Ki | 505.0000 | 2 | 2 |
| cefotiam | Rattus norvegicus (Norway rat) | IC50 | 718.0000 | 1 | 1 |
| cefoperazone | Rattus norvegicus (Norway rat) | IC50 | 298.0000 | 1 | 1 |
| cefoperazone | Rattus norvegicus (Norway rat) | Ki | 480.0000 | 1 | 1 |
| cefadroxil anhydrous | Rattus norvegicus (Norway rat) | IC50 | 2,000.0000 | 1 | 1 |
| pravastatin | Rattus norvegicus (Norway rat) | Ki | 601.0000 | 2 | 2 |
| dibromosulphthalein | Rattus norvegicus (Norway rat) | Ki | 2.7400 | 1 | 1 |
| naproxen | Rattus norvegicus (Norway rat) | Ki | 2.0000 | 1 | 1 |
| cefamandole | Rattus norvegicus (Norway rat) | IC50 | 450.0000 | 1 | 1 |
| estradiol-17 beta-glucuronide | Rattus norvegicus (Norway rat) | Ki | 300.0000 | 2 | 2 |
| nateglinide | Rattus norvegicus (Norway rat) | Ki | 9.2000 | 2 | 2 |
| ceftriaxone | Rattus norvegicus (Norway rat) | IC50 | 840.0000 | 1 | 1 |
| cefotaxime | Rattus norvegicus (Norway rat) | IC50 | 2,000.0000 | 1 | 1 |
| cilastatin | Rattus norvegicus (Norway rat) | IC50 | 2,387.0000 | 1 | 1 |
| piroxicam | Rattus norvegicus (Norway rat) | Ki | 52.0000 | 1 | 1 |
Drugs with Other Measurements
Characterization of the efflux transport of 17beta-estradiol-D-17beta-glucuronide from the brain across the blood-brain barrier.The Journal of pharmacology and experimental therapeutics, , Volume: 298, Issue:1, 2001
Interaction and transport of thiazide diuretics, loop diuretics, and acetazolamide via rat renal organic anion transporter rOAT1.The Journal of pharmacology and experimental therapeutics, , Volume: 295, Issue:1, 2000
Role of organic anion transporter 1 (OAT1) in cephaloridine (CER)-induced nephrotoxicity.Kidney international, , Volume: 56, Issue:6, 1999
Expression cloning and characterization of a novel multispecific organic anion transporter.The Journal of biological chemistry, , Jul-25, Volume: 272, Issue:30, 1997
Expression cloning and characterization of ROAT1. The basolateral organic anion transporter in rat kidney.The Journal of biological chemistry, , Nov-28, Volume: 272, Issue:48, 1997
Elucidation of common pharmacophores from analysis of targeted metabolites transported by the multispecific drug transporter-Organic anion transporter1 (Oat1).Bioorganic & medicinal chemistry, , Jun-01, Volume: 19, Issue:11, 2011
Inhibitory effect of anti-diabetic agents on rat organic anion transporter rOAT1.European journal of pharmacology, , Jun-16, Volume: 398, Issue:2, 2000
Elucidation of common pharmacophores from analysis of targeted metabolites transported by the multispecific drug transporter-Organic anion transporter1 (Oat1).Bioorganic & medicinal chemistry, , Jun-01, Volume: 19, Issue:11, 2011
Inhibitory effect of anti-diabetic agents on rat organic anion transporter rOAT1.European journal of pharmacology, , Jun-16, Volume: 398, Issue:2, 2000
Rat renal organic anion transporter rOAT1 mediates transport of urinary-excreted cephalosporins, but not of biliary-excreted cefoperazone.Drug metabolism and pharmacokinetics, , Volume: 17, Issue:2, 2002
Involvement of rat organic anion transporter 3 (rOAT3) in cephaloridine-induced nephrotoxicity: in comparison with rOAT1.Life sciences, , Mar-08, Volume: 70, Issue:16, 2002
Elucidation of common pharmacophores from analysis of targeted metabolites transported by the multispecific drug transporter-Organic anion transporter1 (Oat1).Bioorganic & medicinal chemistry, , Jun-01, Volume: 19, Issue:11, 2011
Inhibitory effect of anti-diabetic agents on rat organic anion transporter rOAT1.European journal of pharmacology, , Jun-16, Volume: 398, Issue:2, 2000