Integrin alpha-V

An integrin alpha-V that is encoded in the genome of human. [PRO:DNx, UniProtKB:P06756]

Synonyms

Vitronectin receptor;
Vitronectin receptor subunit alpha

Research

Bioassay Publications (58)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	11 (18.97)	18.2507
2000's	20 (34.48)	29.6817
2010's	21 (36.21)	24.3611
2020's	6 (10.34)	2.80

Compounds (22)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
1-(3-chlorophenyl)biguanide	Homo sapiens (human)	IC50	190.6000	1	1
phenyl biguanide	Homo sapiens (human)	IC50	200.0000	1	1
4-chlorophenylbiguanide	Homo sapiens (human)	IC50	148.6000	1	1
paclitaxel	Homo sapiens (human)	IC50	0.0340	1	1
tirofiban	Homo sapiens (human)	IC50	113.8352	6	6
tetraiodothyroacetic acid	Homo sapiens (human)	IC50	0.0624	1	1
arginyl-glycyl-aspartic acid	Homo sapiens (human)	IC50	17.5000	4	4
glycyl-arginyl-glycyl-aspartyl-serine	Homo sapiens (human)	IC50	50.3750	2	2
glycyl- arginyl-glycyl-aspartyl-seryl-prolyl-lysine	Homo sapiens (human)	IC50	0.4733	2	3
d-arg-gly-asp-trp	Homo sapiens (human)	IC50	24.0000	2	2
l 738167	Homo sapiens (human)	IC50	0.0030	1	1
sk&f 107260	Homo sapiens (human)	Ki	0.0035	2	2
cilengitide	Homo sapiens (human)	IC50	1.0582	45	45
cilengitide	Homo sapiens (human)	Ki	0.0010	1	1
l 734217	Homo sapiens (human)	IC50	0.0050	1	1
elarofiban	Homo sapiens (human)	IC50	50.0000	1	1
arginyl-glycyl-aspartyl-phenylalanine	Homo sapiens (human)	IC50	48.0500	2	2
sb 223245	Homo sapiens (human)	IC50	0.1450	3	3
sb 223245	Homo sapiens (human)	Ki	0.0020	7	7
cyclic(arg-gly-asp-d-phe-val)	Homo sapiens (human)	IC50	1.0233	24	24
mk-0429	Homo sapiens (human)	IC50	0.1627	5	5
sb 273005	Homo sapiens (human)	IC50	0.0011	3	3
sb 273005	Homo sapiens (human)	Ki	0.0012	1	1

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
25-hydroxycholesterol	Homo sapiens (human)	Kd	0.0109	1	1
eptifibatide	Homo sapiens (human)	Kd	0.1200	1	1

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
mk-0429	Homo sapiens (human)	SPAV3	0.0001	1	1

Enables

This protein enables 11 target(s):

Target	Category	Definition
virus receptor activity	molecular function	Combining with a virus component and mediating entry of the virus into the cell. [GOC:bf, GOC:dph, PMID:7621403, UniProtKB-KW:KW-1183]
fibronectin binding	molecular function	Binding to a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids. [GOC:hjd]
protease binding	molecular function	Binding to a protease or a peptidase. [GOC:hjd]
integrin binding	molecular function	Binding to an integrin. [GOC:ceb]
voltage-gated calcium channel activity	molecular function	Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:mtg_transport, GOC:tb, ISBN:0815340729]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
coreceptor activity	molecular function	Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity. [GOC:go_curators]
metal ion binding	molecular function	Binding to a metal ion. [GOC:ai]
transforming growth factor beta binding	molecular function	Binding to TGF-beta, transforming growth factor beta, a multifunctional peptide that controls proliferation, differentiation and other functions in many cell types. [ISBN:0198506732]
extracellular matrix binding	molecular function	Binding to a component of the extracellular matrix. [GOC:ai]
extracellular matrix protein binding	molecular function	Binding to a protein that is part of an extracellular matrix. [PMID:22355679]

Located In

This protein is located in 12 target(s):

Target	Category	Definition
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
focal adhesion	cellular component	A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ). [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002]
cell surface	cellular component	The external part of the cell wall and/or plasma membrane. [GOC:jl, GOC:mtg_sensu, GOC:sm]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
lamellipodium membrane	cellular component	The portion of the plasma membrane surrounding a lamellipodium. [GOC:mah]
filopodium membrane	cellular component	The portion of the plasma membrane surrounding a filopodium. [GOC:mah]
microvillus membrane	cellular component	The portion of the plasma membrane surrounding a microvillus. [GOC:mah]
ruffle membrane	cellular component	The portion of the plasma membrane surrounding a ruffle. [GOC:mah]
specific granule membrane	cellular component	The lipid bilayer surrounding a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase. [GOC:bf, PMID:7334549]
phagocytic vesicle	cellular component	A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis. [GOC:go_curators, ISBN:0198506732]
extracellular exosome	cellular component	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
external side of plasma membrane	cellular component	The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface. [GOC:dos, GOC:tb]

Part Of

This protein is part of 9 target(s):

Target	Category	Definition
integrin alphav-beta1 complex	cellular component	An integrin complex that comprises one alphav subunit and one beta1 subunit. [PMID:12297042]
integrin alphav-beta3 complex	cellular component	An integrin complex that comprises one alphav subunit and one beta3 subunit. [PMID:12297042]
integrin alphav-beta5 complex	cellular component	An integrin complex that comprises one alphav subunit and one beta5 subunit. [PMID:12297042]
integrin alphav-beta6 complex	cellular component	An integrin complex that comprises one alphav subunit and one beta6 subunit. [PMID:12297042]
integrin alphav-beta8 complex	cellular component	An integrin complex that comprises one alphav subunit and one beta8 subunit. [PMID:12297042]
integrin complex	cellular component	A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. [PMID:17543136]
alphav-beta3 integrin-PKCalpha complex	cellular component	A protein complex that consists of an alphav-beta3 integrin complex bound to protein kinase C alpha. [GOC:BHF, GOC:ebc, PMID:16014375]
alphav-beta3 integrin-IGF-1-IGF1R complex	cellular component	A protein complex that consists of an alphav-beta3 integrin complex bound to insulin-like growth factor-1 (IGF-1) and type I insulin-like growth factor receptor (IGF1R). IGF1R is a heterotetramer that consists of two alpha-subunits and two beta-subunits. [GOC:BHF, GOC:ebc, PMID:19578119]
alphav-beta3 integrin-HMGB1 complex	cellular component	A protein complex that consists of an alphav-beta3 integrin complex bound to high mobility group box 1 protein. [GOC:BHF, GOC:ebc, PMID:20826760]

Involved In

This protein is involved in 36 target(s):

Target	Category	Definition
angiogenesis	biological process	Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. [ISBN:0878932453]
vasculogenesis	biological process	The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes. [PMID:8999798]
cell adhesion	biological process	The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. [GOC:hb, GOC:pf]
cell-matrix adhesion	biological process	The binding of a cell to the extracellular matrix via adhesion molecules. [GOC:hb]
positive regulation of cytosolic calcium ion concentration	biological process	Any process that increases the concentration of calcium ions in the cytosol. [GOC:ai]
integrin-mediated signaling pathway	biological process	The series of molecular signals initiated by an extracellular ligand binding to an integrin on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mah, GOC:signaling]
positive regulation of cell population proliferation	biological process	Any process that activates or increases the rate or extent of cell proliferation. [GOC:go_curators]
negative regulation of macrophage derived foam cell differentiation	biological process	Any process that decreases the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions. [GOC:add, GOC:BHF, GOC:dph, GOC:tb]
negative regulation of lipid storage	biological process	Any process that decreases the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development. [GOC:BHF, GOC:dph, GOC:tb]
cell migration	biological process	The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration]
positive regulation of cell migration	biological process	Any process that activates or increases the frequency, rate or extent of cell migration. [GOC:go_curators]
cell-substrate adhesion	biological process	The attachment of a cell to the underlying substrate via adhesion molecules. [GOC:mah, GOC:pf]
negative regulation of lipid transport	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]
cell adhesion mediated by integrin	biological process	The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits. [GOC:add, PMID:12213832, PMID:14754902]
positive regulation of osteoblast proliferation	biological process	Any process that activates or increases the rate or extent of osteoblast proliferation. [GOC:mah]
heterotypic cell-cell adhesion	biological process	The attachment of a cell to a cell of a different type via adhesion molecules. [GOC:add]
substrate adhesion-dependent cell spreading	biological process	The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate. [GOC:mah, GOC:pf, PMID:17050732]
wound healing, spreading of epidermal cells	biological process	The migration of an epidermal cell along or through a wound gap that contributes to the reestablishment of a continuous epidermis. [GOC:bf, PMID:15269788]
endodermal cell differentiation	biological process	The process in which a relatively unspecialized cell acquires the specialized features of an endoderm cell, a cell of the inner of the three germ layers of the embryo. [CL:0000223, GOC:yaf, PMID:17624332]
apolipoprotein A-I-mediated signaling pathway	biological process	The series of molecular signals initiated by apolipoprotein A-I binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:bf, GOC:signaling, PMID:16443932]
apoptotic cell clearance	biological process	The recognition and removal of an apoptotic cell by a neighboring cell or by a phagocyte. [GOC:rk, PMID:14685684]
positive regulation of cell adhesion	biological process	Any process that activates or increases the frequency, rate or extent of cell adhesion. [GOC:go_curators]
symbiont entry into host cell	biological process	The process by which a symbiont breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the symbiont or its genome is released into the host cell. [GOC:jl]
negative regulation of lipoprotein metabolic process	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids. [GOC:ai]
regulation of phagocytosis	biological process	Any process that modulates the frequency, rate or extent of phagocytosis, the process in which phagocytes engulf external particulate material. [GOC:ai]
negative chemotaxis	biological process	The directed movement of a motile cell or organism towards a lower concentration of a chemical. [GOC:ai, GOC:bf, GOC:isa_complete]
positive regulation of small GTPase mediated signal transduction	biological process	Any process that activates or increases the frequency, rate or extent of small GTPase mediated signal transduction. [GOC:ai]
ERK1 and ERK2 cascade	biological process	A MAPK cascade containing at least the ERK1 or ERK2 MAP kinases. It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and of ERK1 or ERK2. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier. The ERK1/ERK2 cascade is activated by mitogens, growth factors, G protein-coupled receptors, and results in cellular responses such as cell proliferation, cell differentiation and development. [PMID:20811974, PMID:23125017, PMID:28903453]
calcium ion transmembrane transport	biological process	A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:mah]
transforming growth factor beta production	biological process	The appearance of any member of the transforming growth factor-beta family of cytokines due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Transforming growth factor-beta family members include TGF-B1, TGF-B2, and TGF-B3. [GOC:add, GOC:rv, PMID:16891311, PMID:2022183]
entry into host cell by a symbiont-containing vacuole	biological process	The invasion by a symbiont of a cell of a host organism, forming a vacuole in which the symbiont resides. The vacuole membrane is formed from lipids and proteins derived from both host and symbiont. Begins when the symbiont attaches on to the host cell membrane which invaginates and deepens as the symbiont enters, and ends when the host cell membrane closes behind the newly-formed vacuole. [GOC:jl, PMID:18665841, PMID:8690024, PMID:9580555]
extrinsic apoptotic signaling pathway in absence of ligand	biological process	The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered. [GOC:mtg_apoptosis, PMID:15044679, PMID:20816705]
positive regulation of intracellular signal transduction	biological process	Any process that activates or increases the frequency, rate or extent of intracellular signal transduction. [GOC:BHF, GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie]
negative regulation of entry of bacterium into host cell	biological process	Any process that stops, prevents or reduces the frequency, rate or extent of entry of bacterium into host cell. [GOC:obol]
negative regulation of extrinsic apoptotic signaling pathway	biological process	Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway. [GOC:mtg_apoptosis]
cell-cell adhesion	biological process	The attachment of one cell to another cell via adhesion molecules. [GOC:dos]