| Assay ID | Title | Year | Journal | Article |
|---|
| AID640897 | Cell cycle arrest in human HL60 cells assessed as accumulation at G0/G1 phase at 20 nM after 24 hrs by propidium iodide based flow cytometry analysis (Rvb = 50.6 %) | 2012 | Bioorganic & medicinal chemistry, Feb-01, Volume: 20, Issue:3
| Influence of the skeleton on the cytotoxicity of flavonoids. |
| AID381260 | Cytotoxicity against human KB cells | | | |
| AID335775 | Antimitotic activity in rat ASK cells assessed as reversal of astrocyte formation at 0.16 ug/mL | 1993 | Journal of natural products, Oct, Volume: 56, Issue:10
| Cytotoxic constituents from Hyptis verticillata. |
| AID201788 | Cytotoxic activity against human melanoma SK-MEL-2 was determined | 2002 | Bioorganic & medicinal chemistry letters, Feb-25, Volume: 12, Issue:4
| Synthesis and cytotoxicity of 3,4-diaryl-2(5H)-furanones. |
| AID401471 | Antihepatotoxic activity against 1.5 hrs galactosamine pretreatment-induced cytotoxicity in Wistar rat hepatocytes assessed as glutamic-pyruvic transaminase activity at 0.01 mg/ml after 30 hrs relative to control | | | |
| AID432373 | Inhibition of microtubule assembly in human HeLa cells assessed as loss of stabilization of microtubule bundles by immunofluorescence staining | 2009 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15
| Antitumor activity of deoxypodophyllotoxin isolated from Anthriscus sylvestris: Induction of G2/M cell cycle arrest and caspase-dependent apoptosis. |
| AID633362 | Octanol-water partition coefficient, log P of the compound | 2011 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 21, Issue:24
| Carbamates of 4'-demethyl-4-deoxypodophyllotoxin: synthesis, cytotoxicity and cell cycle effects. |
| AID1324026 | Inhibition of sheep brain tubulin polymerization by DAPI staining-based fluorimetric method | 2016 | Bioorganic & medicinal chemistry, 11-15, Volume: 24, Issue:22
| Methylene versus carbonyl bridge in the structure of new tubulin polymerization inhibitors with tricyclic A-rings. |
| AID8459 | In vitro cytotoxicity against A549 (human lung carcinoma) cell line. | 2002 | Bioorganic & medicinal chemistry letters, Dec-02, Volume: 12, Issue:23
| Prodrugs of 4'-demethyl-4-deoxypodophyllotoxin: synthesis and evaluation of the antitumor activity. |
| AID335771 | Antimitotic activity in rat ASK cells assessed as reversal of astrocyte formation at 100 ug/mL | 1993 | Journal of natural products, Oct, Volume: 56, Issue:10
| Cytotoxic constituents from Hyptis verticillata. |
| AID400480 | Antiviral activity against measles virus infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect at 1 uM | | | |
| AID399567 | Anticancer activity against human BxPC3 cells after 48 hrs by SRB assay | 2004 | Journal of natural products, Feb, Volume: 67, Issue:2
| Antineoplastic agents. 522. Hernandia peltata (Malaysia) and Hernandia nymphaeifolia (Republic of Maldives). |
| AID1657510 | Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell viability by MTT assay | 2020 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 30, Issue:10
| |
| AID401472 | Antihepatotoxic activity against 1.5 hrs galactosamine pretreatment-induced cytotoxicity in Wistar rat hepatocytes assessed as glutamic-pyruvic transaminase activity at 0.1 mg/ml after 30 hrs relative to control | | | |
| AID335785 | Cytotoxicity against human Lu1 cells | 1993 | Journal of natural products, Oct, Volume: 56, Issue:10
| Cytotoxic constituents from Hyptis verticillata. |
| AID432378 | Cell cycle arrest at G2/M phase in human HeLa cells assessed as decrease in cyclin A expression at 0.5 uM after 48 hrs by Western blot analysis | 2009 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15
| Antitumor activity of deoxypodophyllotoxin isolated from Anthriscus sylvestris: Induction of G2/M cell cycle arrest and caspase-dependent apoptosis. |
| AID1295130 | Inhibition of sheep brain tubulin polymerization at 100 uM by DAPI staining-based fluorimetric method | 2016 | Bioorganic & medicinal chemistry, 05-15, Volume: 24, Issue:10
| Studies on phenothiazines: New microtubule-interacting compounds with phenothiazine A-ring as potent antineoplastic agents. |
| AID1324025 | Inhibition of sheep brain tubulin polymerization at 100 uM by DAPI staining-based fluorimetric method relative to control | 2016 | Bioorganic & medicinal chemistry, 11-15, Volume: 24, Issue:22
| Methylene versus carbonyl bridge in the structure of new tubulin polymerization inhibitors with tricyclic A-rings. |
| AID615937 | Cytotoxicity against human HeLa cells after 48 hrs by MTT assay | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9
| Synthesis and biological evaluation of derivatives of 4-deoxypodophyllotoxin as antitumor agents. |
| AID73177 | Cytotoxic effect against GLC4 (human small cell lung carcinoma cell line) using the microculture tetrazolium (MTT) assay based on 2 hr incubation | 1995 | Journal of medicinal chemistry, Jun-09, Volume: 38, Issue:12
| Synthesis and cytotoxicity of novel lignans. |
| AID432376 | Induction of apoptosis in human HeLa cells assessed as caspase 3 cleavage at 0.5 uM | 2009 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15
| Antitumor activity of deoxypodophyllotoxin isolated from Anthriscus sylvestris: Induction of G2/M cell cycle arrest and caspase-dependent apoptosis. |
| AID335780 | Cytotoxicity against human BC1 cells | 1993 | Journal of natural products, Oct, Volume: 56, Issue:10
| Cytotoxic constituents from Hyptis verticillata. |
| AID1061643 | Inhibition of tubulin (unknown origin) polymerization | 2014 | Bioorganic & medicinal chemistry, Jan-01, Volume: 22, Issue:1
| Pyrrolizines: Promising scaffolds for anticancer drugs. |
| AID103429 | In vitro cytotoxicity against MCF-7 (human breast carcinoma) cell line. | 2002 | Bioorganic & medicinal chemistry letters, Dec-02, Volume: 12, Issue:23
| Prodrugs of 4'-demethyl-4-deoxypodophyllotoxin: synthesis and evaluation of the antitumor activity. |
| AID1091874 | In vivo insecticidal activity against pre-third-instar larval stage of Mythimna separata (Oriental armyworm) in corn leaves assessed as inhibition of adult emergence at 1 mg/ml treated for 3 secs before larval infestation on corn leaves by leaf-dipping me | 2010 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8
| Natural products-based insecticidal agents 5. Design, semisynthesis and insecticidal activity of novel 4'-substituted benzenesulfonate derivatives of 4-deoxypodophyllotoxin against Mythimna separata Walker in vivo. |
| AID1123832 | Inhibition of chicken brain microtubule polymerization after 30 mins | 1979 | Journal of medicinal chemistry, Mar, Volume: 22, Issue:3
| Conformational analysis of podophyllotoxin and its congeners. Structure--activity relationship in microtubule assembly. |
| AID318605 | Cytotoxicity against human KM20L2 cells assessed as concentration required for 50% inhibition | 2008 | Journal of natural products, Mar, Volume: 71, Issue:3
| Antineoplastic agents. 536. New sources of naturally occurring cancer cell growth inhibitors from marine organisms, terrestrial plants, and microorganisms(1a,). |
| AID1091875 | In vivo insecticidal activity against pre-third-instar larval stage of Mythimna separata (Oriental armyworm) in corn leaves assessed as inhibition of larval pupation at 1 mg/ml treated for 3 secs before larval infestation on corn leaves by leaf-dipping me | 2010 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8
| Natural products-based insecticidal agents 5. Design, semisynthesis and insecticidal activity of novel 4'-substituted benzenesulfonate derivatives of 4-deoxypodophyllotoxin against Mythimna separata Walker in vivo. |
| AID1322968 | Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay | 2016 | Journal of natural products, 06-24, Volume: 79, Issue:6
| Lignans from the Australian Endemic Plant Austrobaileya scandens. |
| AID640898 | Cell cycle arrest in human HL60 cells assessed as accumulation at S phase at 20 nM after 24 hrs by propidium iodide based flow cytometry analysis (Rvb = 22.3 %) | 2012 | Bioorganic & medicinal chemistry, Feb-01, Volume: 20, Issue:3
| Influence of the skeleton on the cytotoxicity of flavonoids. |
| AID335782 | Cytotoxicity against human HT cells | 1993 | Journal of natural products, Oct, Volume: 56, Issue:10
| Cytotoxic constituents from Hyptis verticillata. |
| AID401474 | Cytotoxicity in Wistar rat hepatocytes assessed as glutamic-pyruvic transaminase activity at 0.01 mg/ml after 30 hrs | | | |
| AID404065 | Antiviral activity against HSV1 infected in human primary amnion cells assessed as inhibition of virus-induced pathogenic effect | 1998 | Journal of natural products, Nov, Volume: 61, Issue:11
| Antiviral activity of lignans. |
| AID103695 | Cytotoxic activity against human breast cancer MCF-7 cell line was determined | 2002 | Bioorganic & medicinal chemistry letters, Feb-25, Volume: 12, Issue:4
| Synthesis and cytotoxicity of 3,4-diaryl-2(5H)-furanones. |
| AID616021 | Induction of cell cycle arrest in human A549 cells assessed as accumulation at S phase at 0.5 uM after 48 hrs using propidium iodide staining by FACS analysis (Rvb = 36.7 %) | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9
| Synthesis and biological evaluation of derivatives of 4-deoxypodophyllotoxin as antitumor agents. |
| AID399564 | Antimicrobial activity against Neisseria gonorrhoeae ATCC 49226 by antimicrobial susceptibility testing | 2004 | Journal of natural products, Feb, Volume: 67, Issue:2
| Antineoplastic agents. 522. Hernandia peltata (Malaysia) and Hernandia nymphaeifolia (Republic of Maldives). |
| AID400478 | Cytotoxicity against african green monkey Vero cells assessed as cell viability at 1 uM by trypan blue exclusion assay | | | |
| AID403984 | Therapeutic index, ratio of MTC for human primary amnion cells to lowest drug level causing inhibition of HSV1 | 1998 | Journal of natural products, Nov, Volume: 61, Issue:11
| Antiviral activity of lignans. |
| AID318604 | Cytotoxicity against human NCIH460 cells assessed as concentration required for 50% inhibition | 2008 | Journal of natural products, Mar, Volume: 71, Issue:3
| Antineoplastic agents. 536. New sources of naturally occurring cancer cell growth inhibitors from marine organisms, terrestrial plants, and microorganisms(1a,). |
| AID1091876 | In vivo insecticidal activity against pre-third-instar larval stage of Mythimna separata (Oriental armyworm) in corn leaves assessed as induction of loss of body liquid at 1 mg/ml treated for 3 secs before larval infestation on corn leaves measured after | 2010 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8
| Natural products-based insecticidal agents 5. Design, semisynthesis and insecticidal activity of novel 4'-substituted benzenesulfonate derivatives of 4-deoxypodophyllotoxin against Mythimna separata Walker in vivo. |
| AID1091877 | In vivo insecticidal activity against pre-third-instar larval stage of Mythimna separata (Oriental armyworm) in corn leaves assessed as induction of larval immobility at 1 mg/ml treated for 3 secs before larval infestation on corn leaves measured after 48 | 2010 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8
| Natural products-based insecticidal agents 5. Design, semisynthesis and insecticidal activity of novel 4'-substituted benzenesulfonate derivatives of 4-deoxypodophyllotoxin against Mythimna separata Walker in vivo. |
| AID399566 | Anticancer activity against mouse P388 cells after 48 hrs | 2004 | Journal of natural products, Feb, Volume: 67, Issue:2
| Antineoplastic agents. 522. Hernandia peltata (Malaysia) and Hernandia nymphaeifolia (Republic of Maldives). |
| AID644045 | Cytotoxicity against human HL60 cells after 48 hrs by CCK-8 assay | 2012 | European journal of medicinal chemistry, Mar, Volume: 49 | Synthesis and biological evaluation of conjugates of deoxypodophyllotoxin and 5-FU as inducer of caspase-3 and -7. |
| AID73178 | Cytotoxic effect against GLC4 (human small cell lung carcinoma cell line) using the microculture tetrazolium (MTT) assay based on continuous incubation | 1995 | Journal of medicinal chemistry, Jun-09, Volume: 38, Issue:12
| Synthesis and cytotoxicity of novel lignans. |
| AID1129935 | Antiproliferative activity against mouse ependymoma cells harboring EPHB2 after 96 hrs by Cell-Titer Glo assay | 2014 | Journal of natural products, Apr-25, Volume: 77, Issue:4
| UPLC-MS-ELSD-PDA as a powerful dereplication tool to facilitate compound identification from small-molecule natural product libraries. |
| AID335774 | Antimitotic activity in rat ASK cells assessed as reversal of astrocyte formation at 0.8 ug/mL | 1993 | Journal of natural products, Oct, Volume: 56, Issue:10
| Cytotoxic constituents from Hyptis verticillata. |
| AID335789 | Antimicrobial activity against Candida albicans ATCC 10231 at 0.2 to 1 ug/ml | 1993 | Journal of natural products, Oct, Volume: 56, Issue:10
| Cytotoxic constituents from Hyptis verticillata. |
| AID335784 | Cytotoxicity against human LNCAP cells | 1993 | Journal of natural products, Oct, Volume: 56, Issue:10
| Cytotoxic constituents from Hyptis verticillata. |
| AID201787 | In vitro cytotoxicity against SK-MEL-2 (human melanoma) cell line. | 2002 | Bioorganic & medicinal chemistry letters, Dec-02, Volume: 12, Issue:23
| Prodrugs of 4'-demethyl-4-deoxypodophyllotoxin: synthesis and evaluation of the antitumor activity. |
| AID1174187 | Inhibition of sheep brain tubulin polymerization by fluorescence assay | 2015 | European journal of medicinal chemistry, Jan-07, Volume: 89 | Studies on indolizines. Evaluation of their biological properties as microtubule-interacting agents and as melanoma targeting compounds. |
| AID432367 | Cell cycle arrest in human HeLa cells assessed as accumulation at G2 phase at 0.5 uM after 24 hrs using propidium iodide staining by FACS analysis | 2009 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15
| Antitumor activity of deoxypodophyllotoxin isolated from Anthriscus sylvestris: Induction of G2/M cell cycle arrest and caspase-dependent apoptosis. |
| AID1301509 | Growth inhibition of human MCF7 cells measured after 48 hrs by sulforhodamine B assay | 2016 | Journal of natural products, Mar-25, Volume: 79, Issue:3
| Antineoplastic Agents. 585. Isolation of Bridelia ferruginea Anticancer Podophyllotoxins and Synthesis of 4-Aza-podophyllotoxin Structural Modifications. |
| AID335773 | Antimitotic activity in rat ASK cells assessed as reversal of astrocyte formation at 4 ug/mL | 1993 | Journal of natural products, Oct, Volume: 56, Issue:10
| Cytotoxic constituents from Hyptis verticillata. |
| AID1091873 | In vivo insecticidal activity against pre-third-instar larval stage of Mythimna separata (Oriental armyworm) in corn leaves assessed as induction of molting to abnormal pupae at 1 mg/ml treated for 3 secs before larval infestation on corn leaves measured | 2010 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8
| Natural products-based insecticidal agents 5. Design, semisynthesis and insecticidal activity of novel 4'-substituted benzenesulfonate derivatives of 4-deoxypodophyllotoxin against Mythimna separata Walker in vivo. |
| AID277522 | Cytotoxicity against androgen sensitive human LNCaP cells | 2007 | Journal of natural products, Feb, Volume: 70, Issue:2
| Lignans from Dysosma versipellis with inhibitory effects on prostate cancer cell lines. |
| AID1174186 | Inhibition of sheep brain tubulin polymerization at 100 uM by fluorescence assay | 2015 | European journal of medicinal chemistry, Jan-07, Volume: 89 | Studies on indolizines. Evaluation of their biological properties as microtubule-interacting agents and as melanoma targeting compounds. |
| AID616020 | Induction of cell cycle arrest in human A549 cells assessed as accumulation at G1 phase at 0.5 uM after 48 hrs using propidium iodide staining by FACS analysis (Rvb = 59.9 %) | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9
| Synthesis and biological evaluation of derivatives of 4-deoxypodophyllotoxin as antitumor agents. |
| AID401476 | Cytotoxicity in Wistar rat hepatocytes assessed as glutamic-pyruvic transaminase activity at 1 mg/ml after 30 hrs | | | |
| AID640905 | Cell cycle arrest in human HL60 cells assessed as accumulation at G0/G1 phase at 20 nM after 48 hrs by propidium iodide based flow cytometry analysis (Rvb = 51.2 %) | 2012 | Bioorganic & medicinal chemistry, Feb-01, Volume: 20, Issue:3
| Influence of the skeleton on the cytotoxicity of flavonoids. |
| AID403993 | Antiviral activity against HSV1 infected in monkey CV-1 cells assessed as inhibition of plaque formation | 1998 | Journal of natural products, Nov, Volume: 61, Issue:11
| Antiviral activity of lignans. |
| AID616019 | Induction of cell cycle arrest in human A549 cells assessed as accumulation at sub-G1 phase at 0.5 uM after 48 hrs using propidium iodide staining by FACS analysis (Rvb = 21.7 %) | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9
| Synthesis and biological evaluation of derivatives of 4-deoxypodophyllotoxin as antitumor agents. |
| AID432371 | Cell cycle arrest in human HeLa cells assessed as accumulation at G2 phase at 0.5 uM after 48 hrs using propidium iodide staining by FACS analysis | 2009 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15
| Antitumor activity of deoxypodophyllotoxin isolated from Anthriscus sylvestris: Induction of G2/M cell cycle arrest and caspase-dependent apoptosis. |
| AID432368 | Cell cycle arrest in human HeLa cells assessed as accumulation at sub G1 phase at 0.5 uM after 48 hrs using propidium iodide staining by FACS analysis | 2009 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15
| Antitumor activity of deoxypodophyllotoxin isolated from Anthriscus sylvestris: Induction of G2/M cell cycle arrest and caspase-dependent apoptosis. |
| AID335779 | Cytotoxicity against human A431 cells | 1993 | Journal of natural products, Oct, Volume: 56, Issue:10
| Cytotoxic constituents from Hyptis verticillata. |
| AID1301507 | Growth inhibition of mouse P388 cells measured after 48 hrs by sulforhodamine B assay | 2016 | Journal of natural products, Mar-25, Volume: 79, Issue:3
| Antineoplastic Agents. 585. Isolation of Bridelia ferruginea Anticancer Podophyllotoxins and Synthesis of 4-Aza-podophyllotoxin Structural Modifications. |
| AID640896 | Cell cycle arrest in human HL60 cells assessed as accumulation at Sub G1 phase at 20 nM after 24 hrs by propidium iodide based flow cytometry analysis (Rvb = 2.3 %) | 2012 | Bioorganic & medicinal chemistry, Feb-01, Volume: 20, Issue:3
| Influence of the skeleton on the cytotoxicity of flavonoids. |
| AID1295131 | Inhibition of sheep brain tubulin polymerization by DAPI staining-based fluorimetric method | 2016 | Bioorganic & medicinal chemistry, 05-15, Volume: 24, Issue:10
| Studies on phenothiazines: New microtubule-interacting compounds with phenothiazine A-ring as potent antineoplastic agents. |
| AID401473 | Antihepatotoxic activity against 1.5 hrs galactosamine pretreatment-induced cytotoxicity in Wistar rat hepatocytes assessed as glutamic-pyruvic transaminase activity at 1 mg/ml after 30 hrs relative to control | | | |
| AID1091879 | In vivo insecticidal activity against pre-third-instar larval stage of Mythimna separata (Oriental armyworm) in corn leaves assessed as corrected mortality rate at 1 mg/ml treated for 3 secs before larval infestation on corn leaves measured after 30 days | 2010 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8
| Natural products-based insecticidal agents 5. Design, semisynthesis and insecticidal activity of novel 4'-substituted benzenesulfonate derivatives of 4-deoxypodophyllotoxin against Mythimna separata Walker in vivo. |
| AID633361 | Cytotoxicity against human HL60 cells assessed as growth inhibition after 48 hrs by CCK-8 assay | 2011 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 21, Issue:24
| Carbamates of 4'-demethyl-4-deoxypodophyllotoxin: synthesis, cytotoxicity and cell cycle effects. |
| AID335788 | Cytotoxicity against human KB cells | 1993 | Journal of natural products, Oct, Volume: 56, Issue:10
| Cytotoxic constituents from Hyptis verticillata. |
| AID732939 | Inhibition of sheep brain tubulin polymerization using DAPI by fluorimetry | 2013 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 23, Issue:1
| Synthesis and anticancer activity of analogues of phenstatin, with a phenothiazine A-ring, as a new class of microtubule-targeting agents. |
| AID363824 | Activity of human recombinant CYP3A4 co-expressed in Escherichia coli with human p450 NADPH reductase assessed as conversion of deoxypodophyllotoxin to epipodophyllotoxin | 2008 | European journal of medicinal chemistry, Jun, Volume: 43, Issue:6
| Metabolic stereoselectivity of cytochrome P450 3A4 towards deoxypodophyllotoxin: In silico predictions and experimental validation. |
| AID318601 | Cytotoxicity against mouse P388 cells assessed as concentration required for 50% inhibition | 2008 | Journal of natural products, Mar, Volume: 71, Issue:3
| Antineoplastic agents. 536. New sources of naturally occurring cancer cell growth inhibitors from marine organisms, terrestrial plants, and microorganisms(1a,). |
| AID618543 | Inhibition of sheep brain tubulin polymerization at 10 uM | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9
| Design, synthesis and antiproliferative activities of biarylolefins based on polyhydroxylated and carbohydrate scaffolds. |
| AID400482 | Antiviral activity against HSV1 infected in african green monkey Vero cells assessed as plaque formation at 1 uM after 4 days by neutral red assay relative to control | | | |
| AID400479 | Antiviral activity against measles virus infected in african green monkey Vero cells assessed as cell rounding at 1 uM | | | |
| AID363828 | Ratio of Vmax to Km for human recombinant CYP3A4 | 2008 | European journal of medicinal chemistry, Jun, Volume: 43, Issue:6
| Metabolic stereoselectivity of cytochrome P450 3A4 towards deoxypodophyllotoxin: In silico predictions and experimental validation. |
| AID432375 | Induction of apoptosis in human HeLa cells assessed as breakdown of nuclei by immunostaining method | 2009 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15
| Antitumor activity of deoxypodophyllotoxin isolated from Anthriscus sylvestris: Induction of G2/M cell cycle arrest and caspase-dependent apoptosis. |
| AID644047 | Cytotoxicity against human HeLa cells after 48 hrs by CCK-8 assay | 2012 | European journal of medicinal chemistry, Mar, Volume: 49 | Synthesis and biological evaluation of conjugates of deoxypodophyllotoxin and 5-FU as inducer of caspase-3 and -7. |
| AID654464 | Cytotoxicity against human KB cells assessed as inhibition of cell proliferation at 10'-6 M after 72 hrs by MTS assay | 2012 | Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
| Synthesis of novel 7-oxo and 7-hydroxy trifluoroallocolchicinoids with cytotoxic effect. |
| AID377254 | Cytotoxicity against mouse JB6 cells by trypan blue exclusion test | 2000 | Journal of natural products, Sep, Volume: 63, Issue:9
| Bioactive constituents of Thuja occidentalis. |
| AID732940 | Inhibition of sheep brain tubulin polymerization at 100 uM using DAPI by fluorimetry | 2013 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 23, Issue:1
| Synthesis and anticancer activity of analogues of phenstatin, with a phenothiazine A-ring, as a new class of microtubule-targeting agents. |
| AID335783 | Cytotoxicity against human KBV1 cells | 1993 | Journal of natural products, Oct, Volume: 56, Issue:10
| Cytotoxic constituents from Hyptis verticillata. |
| AID749586 | Inhibition of sheep brain tubulin assembly by DAPI staining-based fluorescence assay | 2013 | Bioorganic & medicinal chemistry, Jun-01, Volume: 21, Issue:11
| Synthesis and biological evaluation of fluoro analogues of antimitotic phenstatin. |
| AID400477 | Cytotoxicity against african green monkey Vero cells assessed as cell rounding at 1 uM | | | |
| AID318610 | Cytotoxicity against human SF295 cells assessed as concentration required for 50% inhibition | 2008 | Journal of natural products, Mar, Volume: 71, Issue:3
| Antineoplastic agents. 536. New sources of naturally occurring cancer cell growth inhibitors from marine organisms, terrestrial plants, and microorganisms(1a,). |
| AID749587 | Inhibition of sheep brain tubulin assembly at 100 uM by DAPI staining-based fluorescence assay | 2013 | Bioorganic & medicinal chemistry, Jun-01, Volume: 21, Issue:11
| Synthesis and biological evaluation of fluoro analogues of antimitotic phenstatin. |
| AID644046 | Cytotoxicity against human A549 cells after 48 hrs by MTT assay | 2012 | European journal of medicinal chemistry, Mar, Volume: 49 | Synthesis and biological evaluation of conjugates of deoxypodophyllotoxin and 5-FU as inducer of caspase-3 and -7. |
| AID633359 | Cytotoxicity against human SiHa cells assessed as growth inhibition after 48 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 21, Issue:24
| Carbamates of 4'-demethyl-4-deoxypodophyllotoxin: synthesis, cytotoxicity and cell cycle effects. |
| AID432365 | Cell cycle arrest in human HeLa cells assessed as accumulation at G1 phase at 0.5 uM after 24 hrs using propidium iodide staining by FACS analysis | 2009 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15
| Antitumor activity of deoxypodophyllotoxin isolated from Anthriscus sylvestris: Induction of G2/M cell cycle arrest and caspase-dependent apoptosis. |
| AID1301505 | Growth inhibition of human NCI-H460 cells measured after 48 hrs by sulforhodamine B assay | 2016 | Journal of natural products, Mar-25, Volume: 79, Issue:3
| Antineoplastic Agents. 585. Isolation of Bridelia ferruginea Anticancer Podophyllotoxins and Synthesis of 4-Aza-podophyllotoxin Structural Modifications. |
| AID432369 | Cell cycle arrest in human HeLa cells assessed as accumulation at G1 phase at 0.5 uM after 48 hrs using propidium iodide staining by FACS analysis | 2009 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15
| Antitumor activity of deoxypodophyllotoxin isolated from Anthriscus sylvestris: Induction of G2/M cell cycle arrest and caspase-dependent apoptosis. |
| AID400481 | Antiviral activity against measles virus infected in african green monkey Vero cells assessed as plaque formation at 1 uM after 5 days by neutral red assay relative to control | | | |
| AID46745 | Average cytotoxic activity (AC) in three cancer cell lines A549, SK-MEL-2 and MCF-7 was calculated | 2002 | Bioorganic & medicinal chemistry letters, Feb-25, Volume: 12, Issue:4
| Synthesis and cytotoxicity of 3,4-diaryl-2(5H)-furanones. |
| AID432370 | Cell cycle arrest in human HeLa cells assessed as accumulation at S phase at 0.5 uM after 48 hrs using propidium iodide staining by FACS analysis | 2009 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15
| Antitumor activity of deoxypodophyllotoxin isolated from Anthriscus sylvestris: Induction of G2/M cell cycle arrest and caspase-dependent apoptosis. |
| AID432379 | Antiproliferative activity against human HeLa cells at 0.25 uM after 24 hrs | 2009 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15
| Antitumor activity of deoxypodophyllotoxin isolated from Anthriscus sylvestris: Induction of G2/M cell cycle arrest and caspase-dependent apoptosis. |
| AID318602 | Cytotoxicity against human OVCAR-3 cells assessed as concentration required for 50% inhibition | 2008 | Journal of natural products, Mar, Volume: 71, Issue:3
| Antineoplastic agents. 536. New sources of naturally occurring cancer cell growth inhibitors from marine organisms, terrestrial plants, and microorganisms(1a,). |
| AID8460 | Cytotoxic activity against human lung cancer A549 cell line was determined | 2002 | Bioorganic & medicinal chemistry letters, Feb-25, Volume: 12, Issue:4
| Synthesis and cytotoxicity of 3,4-diaryl-2(5H)-furanones. |
| AID598808 | Cytotoxicity against human KB cells after 72 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12
| Three new cytotoxic aryltetralin lignans from Sinopodophyllum emodi. |
| AID354492 | Growth inhibition of mouse P388 cells | 2004 | Journal of natural products, Aug, Volume: 67, Issue:8
| An analysis of cytotoxic botanical formulations used in the traditional medicine of ancient Persia as abortifacients. |
| AID399569 | Anticancer activity against human SF268 cells after 48 hrs by SRB assay | 2004 | Journal of natural products, Feb, Volume: 67, Issue:2
| Antineoplastic agents. 522. Hernandia peltata (Malaysia) and Hernandia nymphaeifolia (Republic of Maldives). |
| AID1301511 | Growth inhibition of human DU145 cells measured after 48 hrs by sulforhodamine B assay | 2016 | Journal of natural products, Mar-25, Volume: 79, Issue:3
| Antineoplastic Agents. 585. Isolation of Bridelia ferruginea Anticancer Podophyllotoxins and Synthesis of 4-Aza-podophyllotoxin Structural Modifications. |
| AID432360 | Cell cycle arrest in human HeLa cells assessed as accumulation at S phase at 0.5 uM after 12 hrs using propidium iodide staining by FACS analysis | 2009 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15
| Antitumor activity of deoxypodophyllotoxin isolated from Anthriscus sylvestris: Induction of G2/M cell cycle arrest and caspase-dependent apoptosis. |
| AID1301508 | Growth inhibition of human BxPC3 cells measured after 48 hrs by sulforhodamine B assay | 2016 | Journal of natural products, Mar-25, Volume: 79, Issue:3
| Antineoplastic Agents. 585. Isolation of Bridelia ferruginea Anticancer Podophyllotoxins and Synthesis of 4-Aza-podophyllotoxin Structural Modifications. |
| AID377256 | Inhibition of 12-O-tetradecanoylphorbol 13-acetate-induced transformation of mouse JB6 cells after 14 days by soft agar transformation assay | 2000 | Journal of natural products, Sep, Volume: 63, Issue:9
| Bioactive constituents of Thuja occidentalis. |
| AID432372 | Inhibition of tubulin polymerization by turbidity assay | 2009 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15
| Antitumor activity of deoxypodophyllotoxin isolated from Anthriscus sylvestris: Induction of G2/M cell cycle arrest and caspase-dependent apoptosis. |
| AID335787 | Cytotoxicity against human ZR-75-1 cells | 1993 | Journal of natural products, Oct, Volume: 56, Issue:10
| Cytotoxic constituents from Hyptis verticillata. |
| AID399568 | Anticancer activity against human MCF7 cells after 48 hrs by SRB assay | 2004 | Journal of natural products, Feb, Volume: 67, Issue:2
| Antineoplastic agents. 522. Hernandia peltata (Malaysia) and Hernandia nymphaeifolia (Republic of Maldives). |
| AID133404 | Antitumor activity against Lewis lung carcinoma (LLC) cells transplanted s.c. into the auxiliary region of the BDF1 mice at a formulable dose of 0.06 mmol/kg/day | 2002 | Bioorganic & medicinal chemistry letters, Dec-02, Volume: 12, Issue:23
| Prodrugs of 4'-demethyl-4-deoxypodophyllotoxin: synthesis and evaluation of the antitumor activity. |
| AID616014 | Cytotoxicity against human SiHa cells after 48 hrs by MTT assay | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9
| Synthesis and biological evaluation of derivatives of 4-deoxypodophyllotoxin as antitumor agents. |
| AID640899 | Cell cycle arrest in human HL60 cells assessed as accumulation at G2/M phase at 20 nM after 24 hrs by propidium iodide based flow cytometry analysis (Rvb = 24.8 %) | 2012 | Bioorganic & medicinal chemistry, Feb-01, Volume: 20, Issue:3
| Influence of the skeleton on the cytotoxicity of flavonoids. |
| AID432381 | Induction of apoptosis in human HeLa cells assessed as caspase 7 cleavage at 0.5 uM | 2009 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15
| Antitumor activity of deoxypodophyllotoxin isolated from Anthriscus sylvestris: Induction of G2/M cell cycle arrest and caspase-dependent apoptosis. |
| AID377257 | Inhibition of 12-O-tetradecanoylphorbol 13-acetate-induced ornithine decarboxylase activity in mouse ME308 cells | 2000 | Journal of natural products, Sep, Volume: 63, Issue:9
| Bioactive constituents of Thuja occidentalis. |
| AID335776 | Antimitotic activity in rat ASK cells assessed as reversal of astrocyte formation at 0.032 ug/mL | 1993 | Journal of natural products, Oct, Volume: 56, Issue:10
| Cytotoxic constituents from Hyptis verticillata. |
| AID432374 | Induction of apoptosis in human HeLa cells assessed as fragmentation of chromosomal DNA by immunostaining method | 2009 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15
| Antitumor activity of deoxypodophyllotoxin isolated from Anthriscus sylvestris: Induction of G2/M cell cycle arrest and caspase-dependent apoptosis. |
| AID640906 | Cell cycle arrest in human HL60 cells assessed as accumulation at S phase at 20 nM after 48 hrs by propidium iodide based flow cytometry analysis (Rvb = 20.9 %) | 2012 | Bioorganic & medicinal chemistry, Feb-01, Volume: 20, Issue:3
| Influence of the skeleton on the cytotoxicity of flavonoids. |
| AID335769 | Toxicity in brine shrimp | 1993 | Journal of natural products, Oct, Volume: 56, Issue:10
| Cytotoxic constituents from Hyptis verticillata. |
| AID432366 | Cell cycle arrest in human HeLa cells assessed as accumulation at S phase at 0.5 uM after 24 hrs using propidium iodide staining by FACS analysis | 2009 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15
| Antitumor activity of deoxypodophyllotoxin isolated from Anthriscus sylvestris: Induction of G2/M cell cycle arrest and caspase-dependent apoptosis. |
| AID432361 | Cell cycle arrest in human HeLa cells assessed as accumulation at sub G1 phase at 0.5 uM after 12 hrs using propidium iodide staining by FACS analysis | 2009 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15
| Antitumor activity of deoxypodophyllotoxin isolated from Anthriscus sylvestris: Induction of G2/M cell cycle arrest and caspase-dependent apoptosis. |
| AID432362 | Cell cycle arrest in human HeLa cells assessed as accumulation at G1 phase at 0.5 uM after 12 hrs using propidium iodide staining by FACS analysis | 2009 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15
| Antitumor activity of deoxypodophyllotoxin isolated from Anthriscus sylvestris: Induction of G2/M cell cycle arrest and caspase-dependent apoptosis. |
| AID335777 | Antimitotic activity in rat ASK cells assessed as reversal of astrocyte formation at 0.0064 ug/mL | 1993 | Journal of natural products, Oct, Volume: 56, Issue:10
| Cytotoxic constituents from Hyptis verticillata. |
| AID335786 | Cytotoxicity against human U373 cells | 1993 | Journal of natural products, Oct, Volume: 56, Issue:10
| Cytotoxic constituents from Hyptis verticillata. |
| AID640904 | Cell cycle arrest in human HL60 cells assessed as accumulation at Sub G1 phase at 20 nM after 48 hrs by propidium iodide based flow cytometry analysis (Rvb = 4 %) | 2012 | Bioorganic & medicinal chemistry, Feb-01, Volume: 20, Issue:3
| Influence of the skeleton on the cytotoxicity of flavonoids. |
| AID1129937 | Retention time of the compound by PDA chromatography | 2014 | Journal of natural products, Apr-25, Volume: 77, Issue:4
| UPLC-MS-ELSD-PDA as a powerful dereplication tool to facilitate compound identification from small-molecule natural product libraries. |
| AID399570 | Anticancer activity against human NCI-H460 cells after 48 hrs by SRB assay | 2004 | Journal of natural products, Feb, Volume: 67, Issue:2
| Antineoplastic agents. 522. Hernandia peltata (Malaysia) and Hernandia nymphaeifolia (Republic of Maldives). |
| AID1301510 | Growth inhibition of human SF268 cells measured after 48 hrs by sulforhodamine B assay | 2016 | Journal of natural products, Mar-25, Volume: 79, Issue:3
| Antineoplastic Agents. 585. Isolation of Bridelia ferruginea Anticancer Podophyllotoxins and Synthesis of 4-Aza-podophyllotoxin Structural Modifications. |
| AID1657511 | Antiproliferative activity against human A549 cells assessed as inhibition of cell viability by MTT assay | 2020 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 30, Issue:10
| |
| AID1091880 | In vivo insecticidal activity against pre-third-instar larval stage of Mythimna separata (Oriental armyworm) in corn leaves assessed as corrected mortality rate at 1 mg/ml treated for 3 secs before larval infestation on corn leaves measured after 20 days | 2010 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8
| Natural products-based insecticidal agents 5. Design, semisynthesis and insecticidal activity of novel 4'-substituted benzenesulfonate derivatives of 4-deoxypodophyllotoxin against Mythimna separata Walker in vivo. |
| AID403994 | Antiviral activity against VSV infected in BHK cells assessed as inhibition of plaque formation | 1998 | Journal of natural products, Nov, Volume: 61, Issue:11
| Antiviral activity of lignans. |
| AID226852 | Inhibition of tubulin polymerization | 2001 | Bioorganic & medicinal chemistry letters, Aug-20, Volume: 11, Issue:16
| Design, synthesis and antiproliferative activity of tripentones: a new series of antitubulin agents. |
| AID335770 | Cytotoxicity in mouse P388 cells | 1993 | Journal of natural products, Oct, Volume: 56, Issue:10
| Cytotoxic constituents from Hyptis verticillata. |
| AID654465 | Cytotoxicity against human KB cells assessed as inhibition of cell proliferation after 72 hrs by MTS assay | 2012 | Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
| Synthesis of novel 7-oxo and 7-hydroxy trifluoroallocolchicinoids with cytotoxic effect. |
| AID399571 | Anticancer activity against human KM20L2 cells after 48 hrs by SRB assay | 2004 | Journal of natural products, Feb, Volume: 67, Issue:2
| Antineoplastic agents. 522. Hernandia peltata (Malaysia) and Hernandia nymphaeifolia (Republic of Maldives). |
| AID432377 | Cell cycle arrest at G2/M phase in human HeLa cells assessed as increase in cyclin B1 expression at 0.5 uM after 3 to 24 hrs by Western blot analysis | 2009 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15
| Antitumor activity of deoxypodophyllotoxin isolated from Anthriscus sylvestris: Induction of G2/M cell cycle arrest and caspase-dependent apoptosis. |
| AID354493 | Growth inhibition of human HT29 cells | 2004 | Journal of natural products, Aug, Volume: 67, Issue:8
| An analysis of cytotoxic botanical formulations used in the traditional medicine of ancient Persia as abortifacients. |
| AID1301506 | Growth inhibition of human KM20L2 cells measured after 48 hrs by sulforhodamine B assay | 2016 | Journal of natural products, Mar-25, Volume: 79, Issue:3
| Antineoplastic Agents. 585. Isolation of Bridelia ferruginea Anticancer Podophyllotoxins and Synthesis of 4-Aza-podophyllotoxin Structural Modifications. |
| AID202808 | Cytotoxicity in SK-MEL-2 (human melanoma) cell line. | 2003 | Bioorganic & medicinal chemistry letters, Aug-18, Volume: 13, Issue:16
| Antitumor activity of unsaturated fatty acid esters of 4'-demethyldeoxypodophyllotoxin. |
| AID399565 | Anticancer activity against human DU145 cells after 48 hrs by SRB assay | 2004 | Journal of natural products, Feb, Volume: 67, Issue:2
| Antineoplastic agents. 522. Hernandia peltata (Malaysia) and Hernandia nymphaeifolia (Republic of Maldives). |
| AID335778 | Antimitotic activity in rat ASK cells assessed as reversal of astrocyte formation at 0.00128 ug/mL | 1993 | Journal of natural products, Oct, Volume: 56, Issue:10
| Cytotoxic constituents from Hyptis verticillata. |
| AID654466 | Inhibition of sheep brain tubulin polymerization at 6.7 x 10'-5 M after 15 mins by turbidimetry analysis | 2012 | Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
| Synthesis of novel 7-oxo and 7-hydroxy trifluoroallocolchicinoids with cytotoxic effect. |
| AID1129936 | Retention time of the compound by ELSD chromatography | 2014 | Journal of natural products, Apr-25, Volume: 77, Issue:4
| UPLC-MS-ELSD-PDA as a powerful dereplication tool to facilitate compound identification from small-molecule natural product libraries. |
| AID1091881 | In vivo insecticidal activity against pre-third-instar larval stage of Mythimna separata (Oriental armyworm) in corn leaves assessed as corrected mortality rate at 1 mg/ml treated for 3 secs before larval infestation on corn leaves measured after 10 days | 2010 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8
| Natural products-based insecticidal agents 5. Design, semisynthesis and insecticidal activity of novel 4'-substituted benzenesulfonate derivatives of 4-deoxypodophyllotoxin against Mythimna separata Walker in vivo. |
| AID318607 | Cytotoxicity against human BXPC3 cells assessed as concentration required for 50% inhibition | 2008 | Journal of natural products, Mar, Volume: 71, Issue:3
| Antineoplastic agents. 536. New sources of naturally occurring cancer cell growth inhibitors from marine organisms, terrestrial plants, and microorganisms(1a,). |
| AID335772 | Antimitotic activity in rat ASK cells assessed as reversal of astrocyte formation at 20 ug/mL | 1993 | Journal of natural products, Oct, Volume: 56, Issue:10
| Cytotoxic constituents from Hyptis verticillata. |
| AID401475 | Cytotoxicity in Wistar rat hepatocytes assessed as glutamic-pyruvic transaminase activity at 0.1 mg/ml after 30 hrs | | | |
| AID369122 | Inhibition of tubulin polymerization | 2009 | Bioorganic & medicinal chemistry, Feb-01, Volume: 17, Issue:3
| Benzopyridooxathiazepine derivatives as novel potent antimitotic agents. |
| AID598807 | Cytotoxicity against human HeLa cells after 72 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12
| Three new cytotoxic aryltetralin lignans from Sinopodophyllum emodi. |
| AID432364 | Cell cycle arrest in human HeLa cells assessed as accumulation at sub G1 phase at 0.5 uM after 24 hrs using propidium iodide staining by FACS analysis | 2009 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15
| Antitumor activity of deoxypodophyllotoxin isolated from Anthriscus sylvestris: Induction of G2/M cell cycle arrest and caspase-dependent apoptosis. |
| AID644048 | Cytotoxicity against human SiHa cells after 48 hrs by MTT assay | 2012 | European journal of medicinal chemistry, Mar, Volume: 49 | Synthesis and biological evaluation of conjugates of deoxypodophyllotoxin and 5-FU as inducer of caspase-3 and -7. |
| AID633360 | Cytotoxicity against human HeLa cells assessed as growth inhibition after 48 hrs by CCK-8 assay | 2011 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 21, Issue:24
| Carbamates of 4'-demethyl-4-deoxypodophyllotoxin: synthesis, cytotoxicity and cell cycle effects. |
| AID1657509 | Antiproliferative activity against human HepG2 cells assessed as inhibition of cell viability by MTT assay | 2020 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 30, Issue:10
| |
| AID277523 | Cytotoxicity against androgen-independent human PC3 cells | 2007 | Journal of natural products, Feb, Volume: 70, Issue:2
| Lignans from Dysosma versipellis with inhibitory effects on prostate cancer cell lines. |
| AID654467 | Inhibition of sheep brain tubulin polymerization after 15 mins by turbidimetry analysis | 2012 | Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
| Synthesis of novel 7-oxo and 7-hydroxy trifluoroallocolchicinoids with cytotoxic effect. |
| AID432363 | Cell cycle arrest in human HeLa cells assessed as accumulation at G2 phase at 0.5 uM after 12 hrs using propidium iodide staining by FACS analysis | 2009 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15
| Antitumor activity of deoxypodophyllotoxin isolated from Anthriscus sylvestris: Induction of G2/M cell cycle arrest and caspase-dependent apoptosis. |
| AID8463 | Cytotoxicity in A549 (human carcinoma) cell line. | 2003 | Bioorganic & medicinal chemistry letters, Aug-18, Volume: 13, Issue:16
| Antitumor activity of unsaturated fatty acid esters of 4'-demethyldeoxypodophyllotoxin. |
| AID716411 | Inhibition of sheep brain tubulin assembly compound incubated for 10 mins at 37 degC followed by 5 mins incubation at 0 degC by turbidimetry | 2012 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 22, Issue:23
| Synthesis and biological evaluation of novel heterocyclic derivatives of combretastatin A-4. |
| AID432382 | Induction of apoptosis in human HeLa cells assessed as PARP cleavage after 24 to 48 hrs by Western blot analysis | 2009 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15
| Antitumor activity of deoxypodophyllotoxin isolated from Anthriscus sylvestris: Induction of G2/M cell cycle arrest and caspase-dependent apoptosis. |
| AID1091878 | In vivo insecticidal activity against pre-third-instar larval stage of Mythimna separata (Oriental armyworm) in corn leaves assessed as reduction in larval movement at 1 mg/ml treated for 3 secs before larval infestation on corn leaves measured after 24 h | 2010 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8
| Natural products-based insecticidal agents 5. Design, semisynthesis and insecticidal activity of novel 4'-substituted benzenesulfonate derivatives of 4-deoxypodophyllotoxin against Mythimna separata Walker in vivo. |
| AID640907 | Cell cycle arrest in human HL60 cells assessed as accumulation at G2/M phase at 20 nM after 48 hrs by propidium iodide based flow cytometry analysis (Rvb = 23.9 %) | 2012 | Bioorganic & medicinal chemistry, Feb-01, Volume: 20, Issue:3
| Influence of the skeleton on the cytotoxicity of flavonoids. |
| AID404066 | Cytotoxicity against human primary amnion cells assessed as morphological changes by microscopic examination | 1998 | Journal of natural products, Nov, Volume: 61, Issue:11
| Antiviral activity of lignans. |
| AID654463 | Cytotoxicity against human KB cells assessed as inhibition of cell proliferation at 10'-5 M after 72 hrs by MTS assay | 2012 | Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
| Synthesis of novel 7-oxo and 7-hydroxy trifluoroallocolchicinoids with cytotoxic effect. |
| AID335781 | Cytotoxicity against human Col2 cells | 1993 | Journal of natural products, Oct, Volume: 56, Issue:10
| Cytotoxic constituents from Hyptis verticillata. |
| AID318611 | Cytotoxicity against human DU145 cells assessed as concentration required for 50% inhibition | 2008 | Journal of natural products, Mar, Volume: 71, Issue:3
| Antineoplastic agents. 536. New sources of naturally occurring cancer cell growth inhibitors from marine organisms, terrestrial plants, and microorganisms(1a,). |
| AID615936 | Cytotoxicity against human A549 cells after 48 hrs by MTT assay | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9
| Synthesis and biological evaluation of derivatives of 4-deoxypodophyllotoxin as antitumor agents. |
| AID633358 | Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 21, Issue:24
| Carbamates of 4'-demethyl-4-deoxypodophyllotoxin: synthesis, cytotoxicity and cell cycle effects. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |