Proteins > Solute carrier family 22 member 6
Page last updated: 2024-08-08 00:06:04
Solute carrier family 22 member 6
A solute carrier family 22 member 6 that is encoded in the genome of mouse. [OMA:Q8VC69, PRO:DNx]
Synonyms
Kidney-specific transport protein;
Novel kidney transcript;
mNKT;
Organic anion transporter 1;
Renal organic anion transporter 1;
mROAT1
Research
Bioassay Publications (3)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (38)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| adipic acid | Mus musculus (house mouse) | Ki | 0.4087 | 1 | 2 |
| benzoic acid | Mus musculus (house mouse) | Ki | 252.0945 | 1 | 2 |
| butyric acid | Mus musculus (house mouse) | Ki | 3,483.6850 | 1 | 2 |
| salicylic acid | Mus musculus (house mouse) | Ki | 144.7720 | 1 | 2 |
| 3-hydroxybutyric acid | Mus musculus (house mouse) | Ki | 3,227.9700 | 1 | 2 |
| hippuric acid | Mus musculus (house mouse) | Ki | 55.8114 | 2 | 3 |
| glutaric acid | Mus musculus (house mouse) | Ki | 6.7304 | 1 | 2 |
| 4-hydroxyphenylpyruvic acid | Mus musculus (house mouse) | Ki | 72.8609 | 3 | 4 |
| phenylpyruvic acid | Mus musculus (house mouse) | Ki | 79.1443 | 2 | 3 |
| propionic acid | Mus musculus (house mouse) | Ki | 8,154.1550 | 1 | 2 |
| pyruvic acid | Mus musculus (house mouse) | Ki | 11,961.3000 | 1 | 2 |
| p-aminohippuric acid | Mus musculus (house mouse) | Ki | 9.3663 | 1 | 2 |
| aspirin | Mus musculus (house mouse) | Ki | 689.4155 | 1 | 2 |
| fluorescite | Mus musculus (house mouse) | Ki | 2.9756 | 1 | 2 |
| ibuprofen | Mus musculus (house mouse) | Ki | 4.6887 | 1 | 2 |
| probenecid | Mus musculus (house mouse) | Ki | 6.3548 | 1 | 2 |
| heptanoic acid | Mus musculus (house mouse) | Ki | 16.6480 | 1 | 2 |
| 2-methylbutanoic acid | Mus musculus (house mouse) | Ki | 916.0055 | 1 | 2 |
| 2-ethylhexanoic acid | Mus musculus (house mouse) | Ki | 56.6170 | 1 | 2 |
| hexanoic acid | Mus musculus (house mouse) | Ki | 37.5768 | 1 | 2 |
| 4-hydroxyphenyllactic acid | Mus musculus (house mouse) | Ki | 223.2180 | 3 | 4 |
| isovaleric acid | Mus musculus (house mouse) | Ki | 2,339.6150 | 1 | 2 |
| suberic acid | Mus musculus (house mouse) | Ki | 33.9922 | 1 | 2 |
| carbenicillin disodium | Mus musculus (house mouse) | Ki | 1,284.1250 | 1 | 2 |
| ticarcillin | Mus musculus (house mouse) | Ki | 527.4035 | 1 | 2 |
| n-acetylaspartic acid | Mus musculus (house mouse) | Ki | 837.2547 | 3 | 3 |
| estradiol 3,17-disulfate | Mus musculus (house mouse) | Ki | 219.3880 | 1 | 2 |
| 3-hydroxybutyric acid | Mus musculus (house mouse) | Ki | 3,235.9400 | 1 | 1 |
| (S)-3-hydroxybutyric acid | Mus musculus (house mouse) | Ki | 3,258.6467 | 3 | 3 |
| N-Acetyl-DL-aspartic acid | Mus musculus (house mouse) | Ki | 835.8820 | 1 | 2 |
| 2-hydroxyisovaleric acid | Mus musculus (house mouse) | Ki | 14,162.7000 | 1 | 2 |
| methotrexate | Mus musculus (house mouse) | Ki | 896.1255 | 1 | 2 |
| alpha-hydroxyglutarate, (l)-isomer | Mus musculus (house mouse) | Ki | 840.0000 | 1 | 1 |
| ochratoxin a | Mus musculus (house mouse) | Ki | 6.2548 | 1 | 2 |
| fumaric acid | Mus musculus (house mouse) | Ki | 613.2975 | 1 | 2 |
| estrone sulfate | Mus musculus (house mouse) | Ki | 203.5870 | 1 | 2 |
| dinoprostone | Mus musculus (house mouse) | Ki | 3.3942 | 1 | 2 |
| penicillin g sodium | Mus musculus (house mouse) | Ki | 329.5655 | 1 | 2 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| p-aminohippuric acid | Mus musculus (house mouse) | Km | 37.3000 | 1 | 1 |
Elucidation of common pharmacophores from analysis of targeted metabolites transported by the multispecific drug transporter-Organic anion transporter1 (Oat1).Bioorganic & medicinal chemistry, , Jun-01, Volume: 19, Issue:11, 2011
Structural variation governs substrate specificity for organic anion transporter (OAT) homologs. Potential remote sensing by OAT family members.The Journal of biological chemistry, , Aug-17, Volume: 282, Issue:33, 2007
Elucidation of common pharmacophores from analysis of targeted metabolites transported by the multispecific drug transporter-Organic anion transporter1 (Oat1).Bioorganic & medicinal chemistry, , Jun-01, Volume: 19, Issue:11, 2011
Structural variation governs substrate specificity for organic anion transporter (OAT) homologs. Potential remote sensing by OAT family members.The Journal of biological chemistry, , Aug-17, Volume: 282, Issue:33, 2007
Elucidation of common pharmacophores from analysis of targeted metabolites transported by the multispecific drug transporter-Organic anion transporter1 (Oat1).Bioorganic & medicinal chemistry, , Jun-01, Volume: 19, Issue:11, 2011
Structural variation governs substrate specificity for organic anion transporter (OAT) homologs. Potential remote sensing by OAT family members.The Journal of biological chemistry, , Aug-17, Volume: 282, Issue:33, 2007
Structural variation governs substrate specificity for organic anion transporter (OAT) homologs. Potential remote sensing by OAT family members.The Journal of biological chemistry, , Aug-17, Volume: 282, Issue:33, 2007
Heterologous expression and functional characterization of a mouse renal organic anion transporter in mammalian cells.The Journal of biological chemistry, , Jan-15, Volume: 274, Issue:3, 1999
Elucidation of common pharmacophores from analysis of targeted metabolites transported by the multispecific drug transporter-Organic anion transporter1 (Oat1).Bioorganic & medicinal chemistry, , Jun-01, Volume: 19, Issue:11, 2011
Structural variation governs substrate specificity for organic anion transporter (OAT) homologs. Potential remote sensing by OAT family members.The Journal of biological chemistry, , Aug-17, Volume: 282, Issue:33, 2007
Elucidation of common pharmacophores from analysis of targeted metabolites transported by the multispecific drug transporter-Organic anion transporter1 (Oat1).Bioorganic & medicinal chemistry, , Jun-01, Volume: 19, Issue:11, 2011
Structural variation governs substrate specificity for organic anion transporter (OAT) homologs. Potential remote sensing by OAT family members.The Journal of biological chemistry, , Aug-17, Volume: 282, Issue:33, 2007
Elucidation of common pharmacophores from analysis of targeted metabolites transported by the multispecific drug transporter-Organic anion transporter1 (Oat1).Bioorganic & medicinal chemistry, , Jun-01, Volume: 19, Issue:11, 2011
Structural variation governs substrate specificity for organic anion transporter (OAT) homologs. Potential remote sensing by OAT family members.The Journal of biological chemistry, , Aug-17, Volume: 282, Issue:33, 2007