Proteins > Myosin light chain kinase family member 4
Page last updated: 2024-08-07 18:45:36

Myosin light chain kinase family member 4

A myosin light chain kinase family member 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q86YV6]

Synonyms

EC 2.7.11.1;
Sugen kinase 85;
SgK085

Research

Bioassay Publications (5)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (40.00)29.6817
2010's3 (60.00)24.3611
2020's0 (0.00)2.80

Compounds (75)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
staurosporineHomo sapiens (human)IC500.053722

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
sb 202190Homo sapiens (human)Kd10.000011
imatinibHomo sapiens (human)Kd10.000022
staurosporineHomo sapiens (human)Kd0.470022
gefitinibHomo sapiens (human)Kd10.000022
lestaurtinibHomo sapiens (human)Kd0.029022
vatalanibHomo sapiens (human)Kd10.000022
ruboxistaurinHomo sapiens (human)Kd10.000022
canertinibHomo sapiens (human)Kd10.000022
birb 796Homo sapiens (human)Kd10.000022
cyc 202Homo sapiens (human)Kd10.000011
sb 203580Homo sapiens (human)Kd10.000022
enzastaurinHomo sapiens (human)Kd0.230011
erlotinibHomo sapiens (human)Kd10.000022
lapatinibHomo sapiens (human)Kd10.000022
sorafenibHomo sapiens (human)Kd10.000033
pd 173955Homo sapiens (human)Kd10.000011
s 1033Homo sapiens (human)Kd10.000011
bms 387032Homo sapiens (human)Kd6.200022
tandutinibHomo sapiens (human)Kd10.000033
vx-745Homo sapiens (human)Kd10.000022
dasatinibHomo sapiens (human)Kd10.000022
zd 6474Homo sapiens (human)Kd10.000022
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1h-imidazol-2-yl)benzamideHomo sapiens (human)Kd10.000011
alvocidibHomo sapiens (human)Kd10.000022
bosutinibHomo sapiens (human)Kd10.000011
su 11248Homo sapiens (human)Kd0.015033
jnj-7706621Homo sapiens (human)Kd10.000011
vx680Homo sapiens (human)Kd2.200022
ekb 569Homo sapiens (human)Kd10.000011
axitinibHomo sapiens (human)Kd10.000011
pd 184352Homo sapiens (human)Kd10.000011
bms345541Homo sapiens (human)Kd0.700011
midostaurinHomo sapiens (human)Kd0.640033
ki 20227Homo sapiens (human)Kd10.000011
cp 724714Homo sapiens (human)Kd10.000011
pi103Homo sapiens (human)Kd10.000022
hki 272Homo sapiens (human)Kd10.000011
tofacitinibHomo sapiens (human)Kd10.000022
n-(6-chloro-7-methoxy-9h-beta-carbolin-8-yl)-2-methylnicotinamideHomo sapiens (human)Kd10.000011
cediranibHomo sapiens (human)Kd10.000011
masitinibHomo sapiens (human)Kd10.000011
pazopanibHomo sapiens (human)Kd10.000022
azd 6244Homo sapiens (human)Kd10.000011
su 14813Homo sapiens (human)Kd0.032022
bibw 2992Homo sapiens (human)Kd10.000011
tg100-115Homo sapiens (human)Kd10.000011
pha 665752Homo sapiens (human)Kd10.000011
6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-oneHomo sapiens (human)Kd0.810011
brivanibHomo sapiens (human)Kd10.000011
at 7519Homo sapiens (human)Kd10.000011
bi 2536Homo sapiens (human)Kd10.000011
nvp-ast487Homo sapiens (human)Kd10.000022
kw 2449Homo sapiens (human)Kd0.170011
abt 869Homo sapiens (human)Kd10.000022
gw 2580Homo sapiens (human)Kd10.000022
crizotinibHomo sapiens (human)Kd10.000011
chir-265Homo sapiens (human)Kd10.000022
motesanibHomo sapiens (human)Kd10.000022
mln8054Homo sapiens (human)Kd10.000022
GDC-0879Homo sapiens (human)Kd10.000011
gsk 461364Homo sapiens (human)Kd10.000011
azd 1152-hqpaHomo sapiens (human)Kd10.000022
nvp-tae684Homo sapiens (human)Kd10.000011
fedratinibHomo sapiens (human)Kd0.130011
gsk690693Homo sapiens (human)Kd10.000011
gdc 0941Homo sapiens (human)Kd0.780011
plx 4720Homo sapiens (human)Kd3.400011
sgx 523Homo sapiens (human)Kd10.000011
quizartinibHomo sapiens (human)Kd10.000022
incb-018424Homo sapiens (human)Kd10.000011
gsk 1838705aHomo sapiens (human)Kd10.000011
gsk 1363089Homo sapiens (human)Kd10.000011
chir 258Homo sapiens (human)Kd0.080022
nintedanibHomo sapiens (human)Kd0.440011
pp242Homo sapiens (human)Kd10.000011

Enables

This protein enables 4 target(s):

TargetCategoryDefinition
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
ATP bindingmolecular functionBinding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]
protein serine kinase activitymolecular functionCatalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. [RHEA:17989]
myosin light chain kinase activitymolecular functionCatalysis of the reaction: ATP + myosin-light-chain = ADP + myosin-light-chain phosphate. [EC:2.7.11.18]