Page last updated: 2024-08-07 16:58:15
Alpha-2C adrenergic receptor
An alpha-2C adrenergic receptor that is encoded in the genome of mouse. [OMA:Q01337, PRO:DNx]
Synonyms
Alpha-2 adrenergic receptor subtype C4;
Alpha-2C adrenoreceptor;
Alpha-2C adrenoceptor;
Alpha-2CAR
Research
Bioassay Publications (5)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 3 (60.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (10)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| oxymetazoline | Mus musculus (house mouse) | Ki | 0.0913 | 3 | 3 |
| prazosin | Mus musculus (house mouse) | Ki | 0.2828 | 5 | 8 |
| terazosin | Mus musculus (house mouse) | Ki | 0.0069 | 1 | 2 |
| yohimbine | Mus musculus (house mouse) | Ki | 0.0281 | 3 | 4 |
| niguldipine | Mus musculus (house mouse) | Ki | 0.0002 | 1 | 2 |
| rauwolscine | Mus musculus (house mouse) | Ki | 0.0138 | 4 | 4 |
| harmine | Mus musculus (house mouse) | Ki | 10.0000 | 1 | 1 |
| dexniguldipine | Mus musculus (house mouse) | Ki | 0.0047 | 1 | 2 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| clonidine | Mus musculus (house mouse) | IC40 | 0.0037 | 1 | 1 |
| phenylephrine | Mus musculus (house mouse) | IC40 | 0.0780 | 1 | 1 |
Design and synthesis of novel alpha1a adrenoceptor-selective dihydropyridine antagonists for the treatment of benign prostatic hyperplasia.Journal of medicinal chemistry, , Dec-17, Volume: 41, Issue:26, 1998
Alpha- and beta-adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification.Journal of medicinal chemistry, , Sep-01, Volume: 38, Issue:18, 1995
Discovery of alpha 1a-adrenergic receptor antagonists based on the L-type Ca2+ channel antagonist niguldipine.Journal of medicinal chemistry, , May-12, Volume: 38, Issue:10, 1995