Proteins > Sialidase-4
Page last updated: 2024-08-07 21:18:59

Sialidase-4

A sialidase-4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8WWR8]

Synonyms

EC 3.2.1.18;
N-acetyl-alpha-neuraminidase 4

Research

Bioassay Publications (11)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (27.27)29.6817
2010's7 (63.64)24.3611
2020's1 (9.09)2.80

Compounds (7)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
zanamivirHomo sapiens (human)IC50350.000087
zanamivirHomo sapiens (human)Ki26.000032
oseltamivirHomo sapiens (human)IC503,666.666733
2-deoxy-2,3-dehydro-n-acetylneuraminic acidHomo sapiens (human)IC5044.91251614
2-deoxy-2,3-dehydro-n-acetylneuraminic acidHomo sapiens (human)Ki4.600043
bcx 1812Homo sapiens (human)IC50500.000022
n-acetylneuraminic acidHomo sapiens (human)IC50500.000011
n-acetylneuraminic acidHomo sapiens (human)IC50500.000011
4-amino-2-deoxy-2,3-didehydro-n-acetylneuraminic acidHomo sapiens (human)IC50720.000011

Enables

This protein enables 5 target(s):

TargetCategoryDefinition
exo-alpha-sialidase activitymolecular functionCatalysis of the hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)-glycosidic linkages of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates. [EC:3.2.1.18]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
exo-alpha-(2->3)-sialidase activitymolecular functionCatalysis of the hydrolysis of alpha-(2->3)-glycosidic linkages of terminal sialic residues in substrates. [EC:3.2.1.18, GOC:mengo_curators]
exo-alpha-(2->6)-sialidase activitymolecular functionCatalysis of the hydrolysis of alpha-(2->6)-glycosidic linkages of terminal sialic residues in substrates. [EC:3.2.1.18, GOC:mengo_curators]
exo-alpha-(2->8)-sialidase activitymolecular functionCatalysis of the hydrolysis of alpha-(2->8)-glycosidic linkages of terminal sialic residues in substrates. [EC:3.2.1.18, GOC:mengo_curators]

Located In

This protein is located in 8 target(s):

TargetCategoryDefinition
mitochondrial outer membranecellular componentThe outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope. [GOC:ai]
mitochondrial inner membranecellular componentThe inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. [GOC:ai]
lysosomecellular componentA small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. [GOC:mah, ISBN:0198506732]
endoplasmic reticulum membranecellular componentThe lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah]
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
organelle inner membranecellular componentThe inner, i.e. lumen-facing, lipid bilayer of an organelle envelope; usually highly selective to most ions and metabolites. [GOC:mah]
neuron projectioncellular componentA prolongation or process extending from a nerve cell, e.g. an axon or dendrite. [GOC:jl, http://www.cogsci.princeton.edu/~wn/]
lysosomal lumencellular componentThe volume enclosed within the lysosomal membrane. [GOC:jl, PMID:15213228]

Active In

This protein is active in 3 target(s):

TargetCategoryDefinition
lysosomecellular componentA small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. [GOC:mah, ISBN:0198506732]
cytoplasmcellular componentThe contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
membranecellular componentA lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]

Involved In

This protein is involved in 4 target(s):

TargetCategoryDefinition
glycoprotein catabolic processbiological processThe chemical reactions and pathways resulting in the breakdown of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. [GOC:go_curators, ISBN:0198506732]
ganglioside catabolic processbiological processThe chemical reactions and pathways resulting in the breakdown of ganglioside, a ceramide oligosaccharide carrying, in addition to other sugar residues, one or more sialic residues. [ISBN:0198547684]
oligosaccharide catabolic processbiological processThe chemical reactions and pathways resulting in the breakdown of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages. [ISBN:0198506732]
negative regulation of neuron projection developmentbiological processAny process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). [GOC:dph, GOC:tb]