kanamycin a profile

Kanamycin: Antibiotic complex produced by Streptomyces kanamyceticus from Japanese soil. Comprises 3 components: kanamycin A, the major component, and kanamycins B and C, the minor components. [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

kanamycin : Kanamycin is a naturally occurring antibiotic complex from Streptomyces kanamyceticus that consists of several components: kanamycin A, the major component (also usually designated as kanamycin), and kanamycins B, C, D and X the minor components. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (1)

kanamycin a is involved in 1 pathway(s), involving a total of 1 unique proteins and 4 unique compounds

ID Source	ID
PubMed CID	6032
CHEMBL ID	1384
CHEBI ID	17630
CHEBI ID	6104
SCHEMBL ID	2735
MeSH ID	M0011918

Synonym
bdbm50031282
(1s,2r,3r,4s,6r)-4,6-diamino-3-(6-amino-6-deoxy-alpha-d-glucopyranosyloxy)-2-hydroxycyclohexyl 3-amino-3-deoxy-alpha-d-glucopyranoside
CHEBI:17630 ,
4,6-diamino-2-hydroxy-1,3-cyclohexylene 3,6'-diamino-3,6'-dideoxydi-d-glucopyranoside
4,6-diamino-2-hydroxy-1,3-cyclohexane 3,6'diamino-3,6'-dideoxydi-alpha-d-glucoside
o-3-amino-3-deoxy-alpha-d-glucopyranosyl-(1->6)-o-(6-amino-6-deoxy-alpha-d-glucopyranosyl-(1->4))-2-deoxy-d-streptamine
KBIO1_000024
DIVK1C_000024
(1s,2r,3r,4s,6r)-4,6-diamino-3-[(6-amino-6-deoxy-alpha-d-glucopyranosyl)oxy]-2-hydroxycyclohexyl 3-amino-3-deoxy-alpha-d-glucopyranoside
BPBIO1_000669
PRESTWICK3_000394
NCGC00179506-01
(2r,3s,4s,5r,6r)-2-(aminomethyl)-6-[(1r,2r,3s,4r,6s)-4,6-diamino-3-[(2s,3r,4s,5s,6r)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-2-hydroxy-cyclohexoxy]tetrahydropyran-3,4,5-triol
liposomal kanamycin
kantrex (1:1 sulfate)
klebcil (1:1 sulfate)
o-3-amino-3-deoxy-.alpha.-d-glucopyranosyl-(1->6)-o-[6-amino-6-deoxy-.alpha.-d-glucopyranosyl-(1->4)]-2-deoxy-d-streptamine
KAN ,
SMP2_000007
BSPBIO_000607
AB00513827
kanamycin a
8063-07-8
C01822
kanamycin
59-01-8
DB01172
IDI1_000024
NINDS_000024
d-streptamine, o-3-amino-3-deoxy-alpha-d-glucopyranosyl-(1-6)-o-(6-amino-6-deoxy-alpha-d-glucopyranosyl-(1,4))-2-deoxy-
hsdb 3107
kanamycine [inn-french]
kanamicina [italian]
glucopyranoside, 4,6-diamino-2-hydroxy-1,3-cyclohexylene 3,6'-diamino-3,6'-dideoxydi-, d-
km (the antibiotic)
kanamycinum [inn-latin]
d-streptamine, o-3-amino-3-deoxy-alpha-d-glucopyranosyl-(1-6)-o-(6-amino-6-deoxy-alpha-d-glucopyranosyl-(1-4))-2-deoxy-
brn 0061647
kanamycin [inn:ban]
einecs 200-411-7
CHEMBL1384
kanamycins ,
(2r,3s,4s,5r,6r)-2-(aminomethyl)-6-[(1r,2r,3s,4r,6s)-4,6-diamino-3-[(2s,3r,4s,5s,6r)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxyoxane-3,4,5-triol
2-(aminomethyl)-6-[4,6-diamino-3-[4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxyoxane-3,4,5-triol
unii-eqk9q303c5
eqk9q303c5 ,
d-streptamine, o-3-amino-3-deoxy-alpha-d-glucopyranosyl-(1->6)-o-(6-amino-6-deoxy-alpha-d-glucopyranosyl-(1->4))-2-deoxy-
d-streptamine, o-3-amino-3-deoxy-alpha-d-glucopyranosyl-(1.fwdarw.6)-o-(6-amino-6-deoxy-alpha-d-glucopyranosyl-(1.fwdarw.4))-2-deoxy-
kanamycine
kanamicina
kanamycinum
kanamycin base
einecs 232-512-7
unii-ruc37xup2p
ruc37xup2p ,
K-0250
kanamycin a [who-ip]
d-streptamine, o-3-amino-3-deoxy-.alpha.-d-glucopyranosyl-(1->6)-o-(6-amino-6-deoxy-.alpha.-d-glucopyranosyl-(1->4))-2-deoxy-
kanamycin a [hsdb]
kanamycin a [mi]
BRD-K08327065-065-01-9
antibiotic complex from streptomyces kanamyceticus containing kanamycin a (major), kanamycin b and kanamycin c
d-streptamine, o-3-amino-3-deoxy-.alpha.-d-glucopyranosyl-(1.fwdarw.6)-o-[6-amino-6-deoxy-.alpha.-d-glucopyranosyl-(1.fwdarw.4)]-2-deoxy-
SCHEMBL2735
SBUJHOSQTJFQJX-NOAMYHISSA-N
CHEBI:6104 ,
AKOS025293505
kanamycin sulfate, antibiotic for culture media use only
DTXSID3023184 ,
(2r,3s,4s,5r,6r)-2-(aminomethyl)-6-{[(1r,2r,3s,4r,6s)-4,6-diamino-3-{[(2s,3r,4s,5s,6r)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-2-hydroxycyclohexyl]oxy}oxane-3,4,5-triol
kanamycin,(s)
(2r,3s,4s,5r,6r)-2-(aminomethyl)-6-((1r,2r,3s,4r,6s)-4,6-diamino-3-((2s,3r,4s,5s,6r)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2h-pyran-2-yloxy)-2-hydroxycyclohexyloxy)tetrahydro-2h-pyran-3,4,5-triol
Q27094615
AS-14003
NCGC00179506-05
kanamycina
gtpl12132
CS-0006792
HY-16566
DTXSID2041171 ,
EN300-19735925
s01aa24
kanamycinum (latin)
kanamycin complex
a07aa08
j01gb04
dtxcid503184

Excerpt	Reference
"Bekanamycin at a lower concentration than that needed to induce electrophysiological effects potentiated verapamil 1 x 10(-8) effects on cardiac pacemaker cells."	( Castrillon, JL; Hernandez, DA; Morales, MA, 1993)

Excerpt	Reference
"The treatment with kanamycin alone resulted in a 2.6-fold increase in the number of the antibiotic-resistant variants in the microbial populations of the wounds."	( Afinogenov, GE; Briantseva, LN; Kopylova, TV; Vladimirov, NI, 1984)

Role	Description
bacterial metabolite	Any prokaryotic metabolite produced during a metabolic reaction in bacteria.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Class	Description
kanamycins
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathway	Proteins	Compounds
Kanamycin Action Pathway	1	4

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Spike glycoprotein	Severe acute respiratory syndrome-related coronavirus	Potency	3.9811	0.0096	10.5250	35.4813	AID1479145
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
ATP-binding cassette sub-family C member 3	Homo sapiens (human)	IC50 (µMol)	133.0000	0.6315	4.4531	9.3000	AID1473740
Multidrug resistance-associated protein 4	Homo sapiens (human)	IC50 (µMol)	133.0000	0.2000	5.6774	10.0000	AID1473741
Bile salt export pump	Homo sapiens (human)	IC50 (µMol)	134.0000	0.1100	7.1903	10.0000	AID1443980; AID1473738
3-oxoacyl-[acyl-carrier-protein] synthase 3	Escherichia coli K-12	IC50 (µMol)	6.8000	6.8000	6.8000	6.8000	AID1169517
Gap junction beta-2 protein	Homo sapiens (human)	IC50 (µMol)	10.4500	9.4000	9.4000	9.4000	AID1385094; AID1740925
Acyl-protein thioesterase 1	Rattus norvegicus (Norway rat)	IC50 (µMol)	110.0000	0.0570	0.0570	0.0570	AID102989
Canalicular multispecific organic anion transporter 1	Homo sapiens (human)	IC50 (µMol)	133.0000	2.4100	6.3433	10.0000	AID1473739
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
xenobiotic metabolic process	ATP-binding cassette sub-family C member 3	Homo sapiens (human)
xenobiotic transmembrane transport	ATP-binding cassette sub-family C member 3	Homo sapiens (human)
bile acid and bile salt transport	ATP-binding cassette sub-family C member 3	Homo sapiens (human)
glucuronoside transport	ATP-binding cassette sub-family C member 3	Homo sapiens (human)
xenobiotic transport	ATP-binding cassette sub-family C member 3	Homo sapiens (human)
transmembrane transport	ATP-binding cassette sub-family C member 3	Homo sapiens (human)
leukotriene transport	ATP-binding cassette sub-family C member 3	Homo sapiens (human)
monoatomic anion transmembrane transport	ATP-binding cassette sub-family C member 3	Homo sapiens (human)
transport across blood-brain barrier	ATP-binding cassette sub-family C member 3	Homo sapiens (human)
prostaglandin secretion	Multidrug resistance-associated protein 4	Homo sapiens (human)
cilium assembly	Multidrug resistance-associated protein 4	Homo sapiens (human)
platelet degranulation	Multidrug resistance-associated protein 4	Homo sapiens (human)
xenobiotic metabolic process	Multidrug resistance-associated protein 4	Homo sapiens (human)
xenobiotic transmembrane transport	Multidrug resistance-associated protein 4	Homo sapiens (human)
bile acid and bile salt transport	Multidrug resistance-associated protein 4	Homo sapiens (human)
prostaglandin transport	Multidrug resistance-associated protein 4	Homo sapiens (human)
urate transport	Multidrug resistance-associated protein 4	Homo sapiens (human)
glutathione transmembrane transport	Multidrug resistance-associated protein 4	Homo sapiens (human)
transmembrane transport	Multidrug resistance-associated protein 4	Homo sapiens (human)
cAMP transport	Multidrug resistance-associated protein 4	Homo sapiens (human)
leukotriene transport	Multidrug resistance-associated protein 4	Homo sapiens (human)
monoatomic anion transmembrane transport	Multidrug resistance-associated protein 4	Homo sapiens (human)
export across plasma membrane	Multidrug resistance-associated protein 4	Homo sapiens (human)
transport across blood-brain barrier	Multidrug resistance-associated protein 4	Homo sapiens (human)
guanine nucleotide transmembrane transport	Multidrug resistance-associated protein 4	Homo sapiens (human)
fatty acid metabolic process	Bile salt export pump	Homo sapiens (human)
bile acid biosynthetic process	Bile salt export pump	Homo sapiens (human)
xenobiotic metabolic process	Bile salt export pump	Homo sapiens (human)
xenobiotic transmembrane transport	Bile salt export pump	Homo sapiens (human)
response to oxidative stress	Bile salt export pump	Homo sapiens (human)
bile acid metabolic process	Bile salt export pump	Homo sapiens (human)
response to organic cyclic compound	Bile salt export pump	Homo sapiens (human)
bile acid and bile salt transport	Bile salt export pump	Homo sapiens (human)
canalicular bile acid transport	Bile salt export pump	Homo sapiens (human)
protein ubiquitination	Bile salt export pump	Homo sapiens (human)
regulation of fatty acid beta-oxidation	Bile salt export pump	Homo sapiens (human)
carbohydrate transmembrane transport	Bile salt export pump	Homo sapiens (human)
bile acid signaling pathway	Bile salt export pump	Homo sapiens (human)
cholesterol homeostasis	Bile salt export pump	Homo sapiens (human)
response to estrogen	Bile salt export pump	Homo sapiens (human)
response to ethanol	Bile salt export pump	Homo sapiens (human)
xenobiotic export from cell	Bile salt export pump	Homo sapiens (human)
lipid homeostasis	Bile salt export pump	Homo sapiens (human)
phospholipid homeostasis	Bile salt export pump	Homo sapiens (human)
positive regulation of bile acid secretion	Bile salt export pump	Homo sapiens (human)
regulation of bile acid metabolic process	Bile salt export pump	Homo sapiens (human)
transmembrane transport	Bile salt export pump	Homo sapiens (human)
fatty acid metabolic process	3-oxoacyl-[acyl-carrier-protein] synthase 3	Escherichia coli K-12
fatty acid biosynthetic process	3-oxoacyl-[acyl-carrier-protein] synthase 3	Escherichia coli K-12
small molecule metabolic process	3-oxoacyl-[acyl-carrier-protein] synthase 3	Escherichia coli K-12
positive regulation of gene expression	Gap junction alpha-1 protein	Homo sapiens (human)
positive regulation of vascular associated smooth muscle cell proliferation	Gap junction alpha-1 protein	Homo sapiens (human)
establishment of mitotic spindle orientation	Gap junction alpha-1 protein	Homo sapiens (human)
osteoblast differentiation	Gap junction alpha-1 protein	Homo sapiens (human)
in utero embryonic development	Gap junction alpha-1 protein	Homo sapiens (human)
neuron migration	Gap junction alpha-1 protein	Homo sapiens (human)
heart looping	Gap junction alpha-1 protein	Homo sapiens (human)
columnar/cuboidal epithelial cell maturation	Gap junction alpha-1 protein	Homo sapiens (human)
lens development in camera-type eye	Gap junction alpha-1 protein	Homo sapiens (human)
cardiac conduction system development	Gap junction alpha-1 protein	Homo sapiens (human)
atrial ventricular junction remodeling	Gap junction alpha-1 protein	Homo sapiens (human)
signal transduction	Gap junction alpha-1 protein	Homo sapiens (human)
cell-cell signaling	Gap junction alpha-1 protein	Homo sapiens (human)
spermatogenesis	Gap junction alpha-1 protein	Homo sapiens (human)
adult heart development	Gap junction alpha-1 protein	Homo sapiens (human)
protein localization	Gap junction alpha-1 protein	Homo sapiens (human)
male gonad development	Gap junction alpha-1 protein	Homo sapiens (human)
negative regulation of gene expression	Gap junction alpha-1 protein	Homo sapiens (human)
cell communication by chemical coupling	Gap junction alpha-1 protein	Homo sapiens (human)
cell communication by electrical coupling	Gap junction alpha-1 protein	Homo sapiens (human)
glutamate secretion	Gap junction alpha-1 protein	Homo sapiens (human)
gap junction assembly	Gap junction alpha-1 protein	Homo sapiens (human)
negative regulation of cell growth	Gap junction alpha-1 protein	Homo sapiens (human)
regulation of bone mineralization	Gap junction alpha-1 protein	Homo sapiens (human)
negative regulation of gonadotropin secretion	Gap junction alpha-1 protein	Homo sapiens (human)
monoatomic ion transmembrane transport	Gap junction alpha-1 protein	Homo sapiens (human)
glutathione transmembrane transport	Gap junction alpha-1 protein	Homo sapiens (human)
maintenance of blood-brain barrier	Gap junction alpha-1 protein	Homo sapiens (human)
T cell proliferation	Gap junction alpha-1 protein	Homo sapiens (human)
embryonic digit morphogenesis	Gap junction alpha-1 protein	Homo sapiens (human)
xenobiotic transport	Gap junction alpha-1 protein	Homo sapiens (human)
positive regulation of canonical NF-kappaB signal transduction	Gap junction alpha-1 protein	Homo sapiens (human)
skeletal muscle tissue regeneration	Gap junction alpha-1 protein	Homo sapiens (human)
positive regulation of striated muscle tissue development	Gap junction alpha-1 protein	Homo sapiens (human)
bone remodeling	Gap junction alpha-1 protein	Homo sapiens (human)
regulation of bone remodeling	Gap junction alpha-1 protein	Homo sapiens (human)
blood vessel morphogenesis	Gap junction alpha-1 protein	Homo sapiens (human)
milk ejection reflex	Gap junction alpha-1 protein	Homo sapiens (human)
regulation of ventricular cardiac muscle cell membrane repolarization	Gap junction alpha-1 protein	Homo sapiens (human)
bone development	Gap junction alpha-1 protein	Homo sapiens (human)
regulation of atrial cardiac muscle cell membrane depolarization	Gap junction alpha-1 protein	Homo sapiens (human)
regulation of ventricular cardiac muscle cell membrane depolarization	Gap junction alpha-1 protein	Homo sapiens (human)
cellular response to pH	Gap junction alpha-1 protein	Homo sapiens (human)
atrial cardiac muscle cell action potential	Gap junction alpha-1 protein	Homo sapiens (human)
cell communication by electrical coupling involved in cardiac conduction	Gap junction alpha-1 protein	Homo sapiens (human)
neuroblast migration	Gap junction alpha-1 protein	Homo sapiens (human)
positive regulation of cold-induced thermogenesis	Gap junction alpha-1 protein	Homo sapiens (human)
export across plasma membrane	Gap junction alpha-1 protein	Homo sapiens (human)
negative regulation of trophoblast cell migration	Gap junction alpha-1 protein	Homo sapiens (human)
cellular response to amyloid-beta	Gap junction alpha-1 protein	Homo sapiens (human)
positive regulation of morphogenesis of an epithelium	Gap junction alpha-1 protein	Homo sapiens (human)
positive regulation of mesodermal cell differentiation	Gap junction alpha-1 protein	Homo sapiens (human)
positive regulation of stem cell proliferation	Gap junction alpha-1 protein	Homo sapiens (human)
heart development	Gap junction alpha-1 protein	Homo sapiens (human)
response to ischemia	Gap junction beta-2 protein	Homo sapiens (human)
cell-cell signaling	Gap junction beta-2 protein	Homo sapiens (human)
sensory perception of sound	Gap junction beta-2 protein	Homo sapiens (human)
cell communication by electrical coupling	Gap junction beta-2 protein	Homo sapiens (human)
gap junction assembly	Gap junction beta-2 protein	Homo sapiens (human)
response to estradiol	Gap junction beta-2 protein	Homo sapiens (human)
response to lipopolysaccharide	Gap junction beta-2 protein	Homo sapiens (human)
response to retinoic acid	Gap junction beta-2 protein	Homo sapiens (human)
response to progesterone	Gap junction beta-2 protein	Homo sapiens (human)
cellular response to oxidative stress	Gap junction beta-2 protein	Homo sapiens (human)
response to human chorionic gonadotropin	Gap junction beta-2 protein	Homo sapiens (human)
decidualization	Gap junction beta-2 protein	Homo sapiens (human)
inner ear development	Gap junction beta-2 protein	Homo sapiens (human)
transmembrane transport	Gap junction beta-2 protein	Homo sapiens (human)
cellular response to glucagon stimulus	Gap junction beta-2 protein	Homo sapiens (human)
cellular response to dexamethasone stimulus	Gap junction beta-2 protein	Homo sapiens (human)
epididymis development	Gap junction beta-2 protein	Homo sapiens (human)
gap junction-mediated intercellular transport	Gap junction beta-2 protein	Homo sapiens (human)
xenobiotic metabolic process	Canalicular multispecific organic anion transporter 1	Homo sapiens (human)
xenobiotic transmembrane transport	Canalicular multispecific organic anion transporter 1	Homo sapiens (human)
negative regulation of gene expression	Canalicular multispecific organic anion transporter 1	Homo sapiens (human)
bile acid and bile salt transport	Canalicular multispecific organic anion transporter 1	Homo sapiens (human)
bilirubin transport	Canalicular multispecific organic anion transporter 1	Homo sapiens (human)
heme catabolic process	Canalicular multispecific organic anion transporter 1	Homo sapiens (human)
xenobiotic export from cell	Canalicular multispecific organic anion transporter 1	Homo sapiens (human)
transmembrane transport	Canalicular multispecific organic anion transporter 1	Homo sapiens (human)
transepithelial transport	Canalicular multispecific organic anion transporter 1	Homo sapiens (human)
leukotriene transport	Canalicular multispecific organic anion transporter 1	Homo sapiens (human)
monoatomic anion transmembrane transport	Canalicular multispecific organic anion transporter 1	Homo sapiens (human)
transport across blood-brain barrier	Canalicular multispecific organic anion transporter 1	Homo sapiens (human)
xenobiotic transport across blood-brain barrier	Canalicular multispecific organic anion transporter 1	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
ATP binding	ATP-binding cassette sub-family C member 3	Homo sapiens (human)
ABC-type xenobiotic transporter activity	ATP-binding cassette sub-family C member 3	Homo sapiens (human)
glucuronoside transmembrane transporter activity	ATP-binding cassette sub-family C member 3	Homo sapiens (human)
ABC-type glutathione S-conjugate transporter activity	ATP-binding cassette sub-family C member 3	Homo sapiens (human)
ABC-type bile acid transporter activity	ATP-binding cassette sub-family C member 3	Homo sapiens (human)
ATP hydrolysis activity	ATP-binding cassette sub-family C member 3	Homo sapiens (human)
ATPase-coupled transmembrane transporter activity	ATP-binding cassette sub-family C member 3	Homo sapiens (human)
xenobiotic transmembrane transporter activity	ATP-binding cassette sub-family C member 3	Homo sapiens (human)
ATPase-coupled inorganic anion transmembrane transporter activity	ATP-binding cassette sub-family C member 3	Homo sapiens (human)
icosanoid transmembrane transporter activity	ATP-binding cassette sub-family C member 3	Homo sapiens (human)
ABC-type transporter activity	ATP-binding cassette sub-family C member 3	Homo sapiens (human)
guanine nucleotide transmembrane transporter activity	Multidrug resistance-associated protein 4	Homo sapiens (human)
protein binding	Multidrug resistance-associated protein 4	Homo sapiens (human)
ATP binding	Multidrug resistance-associated protein 4	Homo sapiens (human)
ABC-type xenobiotic transporter activity	Multidrug resistance-associated protein 4	Homo sapiens (human)
prostaglandin transmembrane transporter activity	Multidrug resistance-associated protein 4	Homo sapiens (human)
urate transmembrane transporter activity	Multidrug resistance-associated protein 4	Homo sapiens (human)
purine nucleotide transmembrane transporter activity	Multidrug resistance-associated protein 4	Homo sapiens (human)
ABC-type glutathione S-conjugate transporter activity	Multidrug resistance-associated protein 4	Homo sapiens (human)
ABC-type bile acid transporter activity	Multidrug resistance-associated protein 4	Homo sapiens (human)
efflux transmembrane transporter activity	Multidrug resistance-associated protein 4	Homo sapiens (human)
15-hydroxyprostaglandin dehydrogenase (NAD+) activity	Multidrug resistance-associated protein 4	Homo sapiens (human)
ATP hydrolysis activity	Multidrug resistance-associated protein 4	Homo sapiens (human)
glutathione transmembrane transporter activity	Multidrug resistance-associated protein 4	Homo sapiens (human)
ATPase-coupled transmembrane transporter activity	Multidrug resistance-associated protein 4	Homo sapiens (human)
xenobiotic transmembrane transporter activity	Multidrug resistance-associated protein 4	Homo sapiens (human)
ATPase-coupled inorganic anion transmembrane transporter activity	Multidrug resistance-associated protein 4	Homo sapiens (human)
ABC-type transporter activity	Multidrug resistance-associated protein 4	Homo sapiens (human)
protein binding	Bile salt export pump	Homo sapiens (human)
ATP binding	Bile salt export pump	Homo sapiens (human)
ABC-type xenobiotic transporter activity	Bile salt export pump	Homo sapiens (human)
bile acid transmembrane transporter activity	Bile salt export pump	Homo sapiens (human)
canalicular bile acid transmembrane transporter activity	Bile salt export pump	Homo sapiens (human)
carbohydrate transmembrane transporter activity	Bile salt export pump	Homo sapiens (human)
ABC-type bile acid transporter activity	Bile salt export pump	Homo sapiens (human)
ATP hydrolysis activity	Bile salt export pump	Homo sapiens (human)
3-oxoacyl-[acyl-carrier-protein] synthase activity	3-oxoacyl-[acyl-carrier-protein] synthase 3	Escherichia coli K-12
acyltransferase activity	3-oxoacyl-[acyl-carrier-protein] synthase 3	Escherichia coli K-12
beta-ketoacyl-acyl-carrier-protein synthase III activity	3-oxoacyl-[acyl-carrier-protein] synthase 3	Escherichia coli K-12
signaling receptor binding	Gap junction alpha-1 protein	Homo sapiens (human)
gap junction channel activity	Gap junction alpha-1 protein	Homo sapiens (human)
protein binding	Gap junction alpha-1 protein	Homo sapiens (human)
beta-catenin binding	Gap junction alpha-1 protein	Homo sapiens (human)
monoatomic ion transmembrane transporter activity	Gap junction alpha-1 protein	Homo sapiens (human)
efflux transmembrane transporter activity	Gap junction alpha-1 protein	Homo sapiens (human)
tubulin binding	Gap junction alpha-1 protein	Homo sapiens (human)
glutathione transmembrane transporter activity	Gap junction alpha-1 protein	Homo sapiens (human)
beta-tubulin binding	Gap junction alpha-1 protein	Homo sapiens (human)
gap junction hemi-channel activity	Gap junction alpha-1 protein	Homo sapiens (human)
gap junction channel activity involved in cardiac conduction electrical coupling	Gap junction alpha-1 protein	Homo sapiens (human)
scaffold protein binding	Gap junction alpha-1 protein	Homo sapiens (human)
gap junction channel activity involved in cell communication by electrical coupling	Gap junction alpha-1 protein	Homo sapiens (human)
protein tyrosine kinase binding	Gap junction alpha-1 protein	Homo sapiens (human)
gap junction channel activity	Gap junction beta-2 protein	Homo sapiens (human)
calcium ion binding	Gap junction beta-2 protein	Homo sapiens (human)
protein binding	Gap junction beta-2 protein	Homo sapiens (human)
identical protein binding	Gap junction beta-2 protein	Homo sapiens (human)
gap junction channel activity involved in cell communication by electrical coupling	Gap junction beta-2 protein	Homo sapiens (human)
protein binding	Canalicular multispecific organic anion transporter 1	Homo sapiens (human)
ATP binding	Canalicular multispecific organic anion transporter 1	Homo sapiens (human)
organic anion transmembrane transporter activity	Canalicular multispecific organic anion transporter 1	Homo sapiens (human)
ABC-type xenobiotic transporter activity	Canalicular multispecific organic anion transporter 1	Homo sapiens (human)
bilirubin transmembrane transporter activity	Canalicular multispecific organic anion transporter 1	Homo sapiens (human)
ABC-type glutathione S-conjugate transporter activity	Canalicular multispecific organic anion transporter 1	Homo sapiens (human)
ATP hydrolysis activity	Canalicular multispecific organic anion transporter 1	Homo sapiens (human)
ATPase-coupled transmembrane transporter activity	Canalicular multispecific organic anion transporter 1	Homo sapiens (human)
xenobiotic transmembrane transporter activity	Canalicular multispecific organic anion transporter 1	Homo sapiens (human)
ATPase-coupled inorganic anion transmembrane transporter activity	Canalicular multispecific organic anion transporter 1	Homo sapiens (human)
ABC-type transporter activity	Canalicular multispecific organic anion transporter 1	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
plasma membrane	ATP-binding cassette sub-family C member 3	Homo sapiens (human)
basal plasma membrane	ATP-binding cassette sub-family C member 3	Homo sapiens (human)
basolateral plasma membrane	ATP-binding cassette sub-family C member 3	Homo sapiens (human)
membrane	ATP-binding cassette sub-family C member 3	Homo sapiens (human)
nucleolus	Multidrug resistance-associated protein 4	Homo sapiens (human)
Golgi apparatus	Multidrug resistance-associated protein 4	Homo sapiens (human)
plasma membrane	Multidrug resistance-associated protein 4	Homo sapiens (human)
membrane	Multidrug resistance-associated protein 4	Homo sapiens (human)
basolateral plasma membrane	Multidrug resistance-associated protein 4	Homo sapiens (human)
apical plasma membrane	Multidrug resistance-associated protein 4	Homo sapiens (human)
platelet dense granule membrane	Multidrug resistance-associated protein 4	Homo sapiens (human)
external side of apical plasma membrane	Multidrug resistance-associated protein 4	Homo sapiens (human)
plasma membrane	Multidrug resistance-associated protein 4	Homo sapiens (human)
basolateral plasma membrane	Bile salt export pump	Homo sapiens (human)
Golgi membrane	Bile salt export pump	Homo sapiens (human)
endosome	Bile salt export pump	Homo sapiens (human)
plasma membrane	Bile salt export pump	Homo sapiens (human)
cell surface	Bile salt export pump	Homo sapiens (human)
apical plasma membrane	Bile salt export pump	Homo sapiens (human)
intercellular canaliculus	Bile salt export pump	Homo sapiens (human)
intracellular canaliculus	Bile salt export pump	Homo sapiens (human)
recycling endosome	Bile salt export pump	Homo sapiens (human)
recycling endosome membrane	Bile salt export pump	Homo sapiens (human)
extracellular exosome	Bile salt export pump	Homo sapiens (human)
membrane	Bile salt export pump	Homo sapiens (human)
cytoplasm	3-oxoacyl-[acyl-carrier-protein] synthase 3	Escherichia coli K-12
cytosol	3-oxoacyl-[acyl-carrier-protein] synthase 3	Escherichia coli K-12
Golgi membrane	Gap junction alpha-1 protein	Homo sapiens (human)
nucleoplasm	Gap junction alpha-1 protein	Homo sapiens (human)
cytoplasm	Gap junction alpha-1 protein	Homo sapiens (human)
mitochondrion	Gap junction alpha-1 protein	Homo sapiens (human)
endoplasmic reticulum membrane	Gap junction alpha-1 protein	Homo sapiens (human)
Golgi apparatus	Gap junction alpha-1 protein	Homo sapiens (human)
cytosol	Gap junction alpha-1 protein	Homo sapiens (human)
intermediate filament	Gap junction alpha-1 protein	Homo sapiens (human)
plasma membrane	Gap junction alpha-1 protein	Homo sapiens (human)
fascia adherens	Gap junction alpha-1 protein	Homo sapiens (human)
gap junction	Gap junction alpha-1 protein	Homo sapiens (human)
focal adhesion	Gap junction alpha-1 protein	Homo sapiens (human)
intercalated disc	Gap junction alpha-1 protein	Homo sapiens (human)
apical plasma membrane	Gap junction alpha-1 protein	Homo sapiens (human)
lateral plasma membrane	Gap junction alpha-1 protein	Homo sapiens (human)
cell junction	Gap junction alpha-1 protein	Homo sapiens (human)
Golgi-associated vesicle membrane	Gap junction alpha-1 protein	Homo sapiens (human)
intracellular membrane-bounded organelle	Gap junction alpha-1 protein	Homo sapiens (human)
contractile muscle fiber	Gap junction alpha-1 protein	Homo sapiens (human)
cell-cell contact zone	Gap junction alpha-1 protein	Homo sapiens (human)
membrane raft	Gap junction alpha-1 protein	Homo sapiens (human)
tight junction	Gap junction alpha-1 protein	Homo sapiens (human)
connexin complex	Gap junction alpha-1 protein	Homo sapiens (human)
endoplasmic reticulum-Golgi intermediate compartment	Gap junction beta-2 protein	Homo sapiens (human)
plasma membrane	Gap junction beta-2 protein	Homo sapiens (human)
gap junction	Gap junction beta-2 protein	Homo sapiens (human)
lateral plasma membrane	Gap junction beta-2 protein	Homo sapiens (human)
cell body	Gap junction beta-2 protein	Homo sapiens (human)
perinuclear region of cytoplasm	Gap junction beta-2 protein	Homo sapiens (human)
astrocyte projection	Gap junction beta-2 protein	Homo sapiens (human)
connexin complex	Gap junction beta-2 protein	Homo sapiens (human)
virion membrane	Spike glycoprotein	Severe acute respiratory syndrome-related coronavirus
plasma membrane	Canalicular multispecific organic anion transporter 1	Homo sapiens (human)
cell surface	Canalicular multispecific organic anion transporter 1	Homo sapiens (human)
apical plasma membrane	Canalicular multispecific organic anion transporter 1	Homo sapiens (human)
intercellular canaliculus	Canalicular multispecific organic anion transporter 1	Homo sapiens (human)
apical plasma membrane	Canalicular multispecific organic anion transporter 1	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (1441)

Assay ID	Title	Year	Journal	Article
AID560249	Antibacterial activity against Staphylococcus aureus RN4220 harboring tet(L), dfrK gene by CLSI method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Novel ABC transporter gene, vga(C), located on a multiresistance plasmid from a porcine methicillin-resistant Staphylococcus aureus ST398 strain.
AID206015	Minimum inhibitory concentration (MIC) was measured against Staphylococcus aureus ATCC 25923.	1995	Journal of medicinal chemistry, Nov-10, Volume: 38, Issue:23	Synthesis and antimicrobial and toxicological studies of amino acid and peptide derivatives of kanamycin A and netilmicin.
AID293860	Antibacterial activity against methicillin-resistant Staphylococcus aureus CMAH 0504 after 24 hrs by two fold dilution method	2007	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6	Synthesis of pseudopeptides based L-tryptophan as a potential antimicrobial agent.
AID725077	Antimicrobial activity against Staphylococcus aureus after 12 to 18 hrs by micro-well dilution method	2013	European journal of medicinal chemistry, Jan, Volume: 59	Synthesis and antibacterial and antifungal evaluation of some chalcone based sulfones and bisulfones.
AID126451	Dissociation constant for binding to mitochondrial 12S rRNA construct M4 was determined	2002	Bioorganic & medicinal chemistry letters, Aug-19, Volume: 12, Issue:16	Decoding region bubble size and aminoglycoside antibiotic binding.
AID164252	Antibacterial activity expressed as MIC value was determined on Pseudomonas aeruginosa A-20717 organism	1986	Journal of medicinal chemistry, May, Volume: 29, Issue:5	Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin.
AID1585670	Antibacterial activity against methicillin-resistant Staphylococcus aureus assessed as zone of inhibition at 30 ug/mL after 24 hrs by agar disc diffusion method	2019	European journal of medicinal chemistry, Jan-15, Volume: 162	Discovery of novel arylethenesulfonyl fluorides as potential candidates against methicillin-resistant of Staphylococcus aureus (MRSA) for overcoming multidrug resistance of bacterial infections.
AID476723	Antibacterial activity against Staphylococcus aureus ATCC 6538 after 24 hrs by colorimetric method using dye MTT	2010	Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7	Synthesis, molecular modeling and biological evaluation of PSB as targeted antibiotics.
AID584121	Antimicrobial activity against methicillin-resistant Staphylococcus aureus ST398 isolate 11 containing apmA, erm(B), tet(L), tet(M), tet(K), dfrK, aadD, mecA, blaZ resistance genes by CLSI M31-A3 method	2011	Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1	Novel apramycin resistance gene apmA in bovine and porcine methicillin-resistant Staphylococcus aureus ST398 isolates.
AID1077165	Antibacterial activity against Pseudomonas aeruginosa after 12 hrs by MTT assay	2014	European journal of medicinal chemistry, Apr-09, Volume: 76	Design and synthesis of 2-styryl of 5-Nitroimidazole derivatives and antimicrobial activities as FabH inhibitors.
AID599148	Antibacterial activity against Pseudomonas fluorescens after 24 hrs by MTT assay	2008	European journal of medicinal chemistry, Mar, Volume: 43, Issue:3	Synthesis, crystal structure and antimicrobial activity of deoxybenzoin derivatives from genistein.
AID1657552	Antimicrobial activity against methicillin-resistant Staphylococcus aureus incubated for 7 hrs by alamar Blue assay
AID524260	Antibacterial activity against Escherichia coli NKE96 harboring deletion mutation in acrB protein	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Effect of NlpE overproduction on multidrug resistance in Escherichia coli.
AID544271	Antimicrobial activity against Enterococcus faecalis NKH1 harboring pMG2200-like plasmid after 24 hrs by agar dilution method	2009	Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2	Isolation of VanB-type Enterococcus faecalis strains from nosocomial infections: first report of the isolation and identification of the pheromone-responsive plasmids pMG2200, Encoding VanB-type vancomycin resistance and a Bac41-type bacteriocin, and pMG2
AID470175	Antitubercular activity against Mycobacterium tuberculosis H37Ra after 4 days by microplate alamar blue assay	2009	Journal of natural products, Nov, Volume: 72, Issue:11	Diterpenes, sesquiterpenes, and a sesquiterpene-coumarin conjugate from Jatropha integerrima.
AID1191415	Antimicrobial activity against Escherichia coli PCM 2561 (ATCC 8739, DSM 1576) after 16 to 20 hrs by broth micro-dilution method	2015	Bioorganic & medicinal chemistry letters, Feb-01, Volume: 25, Issue:3	In vitro studies of antimicrobial activity of Gly-His-Lys conjugates as potential and promising candidates for therapeutics in skin and tissue infections.
AID501179	Antimicrobial activity against methicillin sensitive Staphylococcus aureus 375 at 30 ug after 18 hrs by agar diffusion method	2009	Journal of natural products, Oct, Volume: 72, Issue:10	Norselic acids A-E, highly oxidized anti-infective steroids that deter mesograzer predation, from the Antarctic sponge Crella sp.
AID1265793	Antibacterial activity against Staphylococcus aureus NRS22 (USA 600) by microdilution method	2015	Journal of medicinal chemistry, Dec-10, Volume: 58, Issue:23	Synthesis and Bioactivities of Kanamycin B-Derived Cationic Amphiphiles.
AID1478539	Resistance index, ratio of MIC for Escherichia coli ATCC 35218 in 15th subculture to MIC for Escherichia coli ATCC 35218 in first subculture	2017	Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11	Covalently linked kanamycin - Ciprofloxacin hybrid antibiotics as a tool to fight bacterial resistance.
AID1191414	Antimicrobial activity against Escherichia coli DSM11250 (PCM2560, NTCC 10538) after 16 to 20 hrs by broth micro-dilution method	2015	Bioorganic & medicinal chemistry letters, Feb-01, Volume: 25, Issue:3	In vitro studies of antimicrobial activity of Gly-His-Lys conjugates as potential and promising candidates for therapeutics in skin and tissue infections.
AID1167350	Antibacterial activity against wild type Pseudomonas aeruginosa PAO1 after 18 to 24 hrs by two-fold broth microdilution method	2014	Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21	Design, synthesis, and antibacterial properties of dual-ligand inhibitors of acetyl-CoA carboxylase.
AID1418826	Antibacterial activity against Escherichia coli at 1 mg/ml after 48 hrs by agar well diffusion method	2018	Bioorganic & medicinal chemistry, 11-15, Volume: 26, Issue:21	Simplified lipid II-binding antimicrobial peptides: Design, synthesis and antimicrobial activity of bioconjugates of nisin rings A and B with pore-forming peptides.
AID424601	Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH378 (SCV-50) harboring -1 frameshift mutation at nucleotide 221 in rplF gene after 18 to 24 hrs by Etest strip assay	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID501183	Antimicrobial activity against Escherichia coli 389 at 30 ug after 18 hrs by agar diffusion method	2009	Journal of natural products, Oct, Volume: 72, Issue:10	Norselic acids A-E, highly oxidized anti-infective steroids that deter mesograzer predation, from the Antarctic sponge Crella sp.
AID749377	Antimicrobial activity against Pseudomonas aeruginosa ATCC 27853 after 24 hrs by two fold serial dilution method	2013	Bioorganic & medicinal chemistry, Jun-01, Volume: 21, Issue:11	Design, synthesis and antimicrobial activities evaluation of Schiff base derived from secnidazole derivatives as potential FabH inhibitors.
AID283548	Antibacterial activity against Pseudomonas aeruginosa FE63 containing inactivated rplY and PA5471 genes by microdilution method	2007	Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3	Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides.
AID574785	Antimycobacterial activity against extensively drug-resistant Mycobacterium tuberculosis isolate 2403 obtained from sputum of patient at 4 ug/ml by Bactec MGIT960 modified proportion method	2010	Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11	Emergence and molecular characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates from the Delhi Region in India.
AID771507	Antibacterial activity against Bacillus subtilis 168 by dilution technique	2013	European journal of medicinal chemistry, Oct, Volume: 68	Synthesis and biological evaluation of novel ocotillol-type triterpenoid derivatives as antibacterial agents.
AID1731001	Antibacterial activity against Escherichia coli DH5-alpha assessed as inhibition of bacterial growth measured after 18 hrs by two fold serial dilution method	2021	European journal of medicinal chemistry, Mar-05, Volume: 213	Design and synthesis of mycobacterial pks13 inhibitors: Conformationally rigid tetracyclic molecules.
AID1868097	Antibacterial activity against Staphylococcus aureus ATCC 9144 assessed as inhibition of visible bacterial growth incubated for 18 hrs by CLSI protocol based assay	2022	Journal of natural products, 05-27, Volume: 85, Issue:5	Enceleamycins A-C, Furo-Naphthoquinones from
AID1905615	Antimicrobial activity against kanamycin-resistant Escherichia coli ATCC 25922	2022	Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7	Novel β-Hairpin Antimicrobial Peptides Containing the β-Turn Sequence of -RRRF- Having High Cell Selectivity and Low Incidence of Drug Resistance.
AID625836	Antibacterial activity against Escherichia coli by micro-broth dilution method	2011	Bioorganic & medicinal chemistry letters, Nov-01, Volume: 21, Issue:21	Micelles catalyzed chemoselective synthesis 'in water' and biological evaluation of oxygen containing hetero-1,4-naphthoquinones as potential antifungal agents.
AID718269	Antimicrobial activity against Escherichia coli DH5[alpha]	2012	Journal of natural products, Dec-28, Volume: 75, Issue:12	Marthiapeptide A, an anti-infective and cytotoxic polythiazole cyclopeptide from a 60 L scale fermentation of the deep sea-derived Marinactinospora thermotolerans SCSIO 00652.
AID1562311	Antimycobacterial activity against Mycobacterium smegmatis atR10 assessed as decrease in drug resistance development at 5 ug/disc after 2 to 3 days by paper disc method	2019	European journal of medicinal chemistry, Sep-15, Volume: 178	Synthesis and antimycobacterial activity of imidazo[1,2-b][1,2,4,5]tetrazines.
AID477423	Selectivity ratio of MIC for MBX-1090-resistant Staphylococcus aureus isolate d20A1 to MIC for Staphylococcus aureus NCTC 8325	2010	Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6	Efflux-mediated bis-indole resistance in Staphylococcus aureus reveals differential substrate specificities for MepA and MepR.
AID1455933	Antibacterial activity against Escherichia coli after 48 hrs by broth micro-dilution method	2017	Journal of natural products, 02-24, Volume: 80, Issue:2	Nabscessins A and B, Aminocyclitol Derivatives from Nocardia abscessus IFM 10029
AID424587	Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH377 (SCV-49) harboring +1 frameshift mutation at nucleotide 23 in rplF gene after 18 to 24 hrs by Etest strip assay	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID534341	Antimicrobial activity against Burkholderia pseudomallei Bp227 harboring deleted (bpeAB-oprA)::FRT gene after 24 hrs by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8	The BpeAB-OprB efflux pump of Burkholderia pseudomallei 1026b does not play a role in quorum sensing, virulence factor production, or extrusion of aminoglycosides but is a broad-spectrum drug efflux system.
AID1079937	Severe hepatitis, defined as possibly life-threatening liver failure or through clinical observations. Value is number of references indexed. [column 'MASS' in source]
AID1477416	Antibacterial activity against wild type Mycobacterium tuberculosis H37Rv grown in GAST/Fe medium measured on day 14 post inoculation by broth microdilution method	2017	Journal of medicinal chemistry, 12-28, Volume: 60, Issue:24	Novel Antitubercular 6-Dialkylaminopyrimidine Carboxamides from Phenotypic Whole-Cell High Throughput Screening of a SoftFocus Library: Structure-Activity Relationship and Target Identification Studies.
AID69633	Minimum inhibitory concentration was measured against Escherichia coli A 9632	1980	Journal of medicinal chemistry, Jan, Volume: 23, Issue:1	Aminoglycoside antibiotics. 3. Epimino derivatives of neamine, ribostamycin, and kanamycin B.
AID490133	Antibacterial activity against Pseudomonas aeruginosa ATCC 13525 after 24 hrs by MTT assay	2010	European journal of medicinal chemistry, Jul, Volume: 45, Issue:7	Synthesis of some N-alkyl substituted urea derivatives as antibacterial and antifungal agents.
AID1738324	Antibacterial activity against multidrug-resistant Staphylococcus aureus NRS271 assessed as reduction in bacterial growth incubated for 16 to 18 hrs by two fold serial dilution method	2020	European journal of medicinal chemistry, Jul-15, Volume: 198	Capsaicin derivatives with nitrothiophene substituents: Design, synthesis and antibacterial activity against multidrug-resistant S. aureus.
AID1906415	Antibacterial activity against Escherichia coli ATCC 25922 assessed as reduction in microbial growth incubated for 24 hrs by microbroth dilution method	2022	European journal of medicinal chemistry, May-05, Volume: 235	Amphiphilic cyclic peptide [W
AID625284	Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatic failure	2011	PLoS computational biology, Dec, Volume: 7, Issue:12	Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID520870	Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus saprophyticus isolate TSU47 isolated from genitourinary tracts of acute cystitis patient after 24 hrs at 35 degC by agar dilution method	2008	Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6	Methicillin-resistant Staphylococcus saprophyticus isolates carrying staphylococcal cassette chromosome mec have emerged in urogenital tract infections.
AID1869574	Bactericidal activity against Pseudomonas aeruginosa DSM 19880 assessed as reduction in colony count and measured after 3 days by agar diffusion assay	2022	Journal of natural products, 06-24, Volume: 85, Issue:6	Triculamin: An Unusual Lasso Peptide with Potent Antimycobacterial Activity.
AID601495	Antibacterial activity against Escherichia coli MTCC 739 at 30 ug/disc after 24 hrs	2011	European journal of medicinal chemistry, Jun, Volume: 46, Issue:6	Evaluation of antioxidant and antimicrobial activities of Bergenin and its derivatives obtained by chemoenzymatic synthesis.
AID1182143	Antitubercular activity against Mycobacterium smegmatis by checkerboard assay in presence of chlorpromazine-N-S-dioxide	2014	Bioorganic & medicinal chemistry, Aug-15, Volume: 22, Issue:16	Pharmacologically active metabolites, combination screening and target identification-driven drug repositioning in antituberculosis drug discovery.
AID164250	Antibacterial activity expressed as MIC value was determined on Pseudomonas aeruginosa A-20601 organism	1986	Journal of medicinal chemistry, May, Volume: 29, Issue:5	Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin.
AID102989	In vitro inhibition of lysosomal phospholipase activity for release of labeled lysophosphatidylcholine	1991	Journal of medicinal chemistry, Apr, Volume: 34, Issue:4	New derivatives of kanamycin B obtained by modifications and substitutions in position 6''. 2. In vitro and computer-aided toxicological evaluation with respect to interactions with phosphatidylinositol.
AID1565719	Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 33591 incubated for 18 hrs by two fold dilution method	2019	European journal of medicinal chemistry, Nov-15, Volume: 182	Scalable and cost-effective tosylation-mediated synthesis of antifungal and fungal diagnostic 6″-Modified amphiphilic kanamycins.
AID1337801	Antibacterial activity against Bacillus subtilis NCIM 2079 measured after 12 hrs	2017	European journal of medicinal chemistry, Jan-05, Volume: 125	Quinolidene-rhodanine conjugates: Facile synthesis and biological evaluation.
AID524385	Antibacterial activity against Escherichia coli NKE156 harboring deletion mutation in acrB protein and vector expressing acrD gene	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Effect of NlpE overproduction on multidrug resistance in Escherichia coli.
AID283530	Antibacterial activity against Pseudomonas aeruginosa FE10 with inactivated nuoG gene by microdilution method	2007	Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3	Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides.
AID1905565	Antimicrobial activity against Klebsiella pneumoniae ATCC 700603 assessed as reduction of bacterial growth incubated for 18 hrs by CLSI protocol based broth microdilution method	2022	Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7	Novel β-Hairpin Antimicrobial Peptides Containing the β-Turn Sequence of -RRRF- Having High Cell Selectivity and Low Incidence of Drug Resistance.
AID592502	Antibacterial activity against Legionella pneumophila Corby by microtiter plate assay	2011	Journal of natural products, Mar-25, Volume: 74, Issue:3	Diversonol and blennolide derivatives from the endophytic fungus Microdiplodia sp.: absolute configuration of diversonol.
AID424594	Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH349 (SCV-21) harboring -1 frameshift mutation at nucleotide 404 in rplF gene after 18 to 24 hrs by Etest strip assay	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID532990	Antibacterial activity against Klebsiella pneumoniae NCIM 2883 assessed as growth inhibition in presence of 10 mM N-Acetylcysteine	2010	Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8	N-acetylcysteine-mediated modulation of bacterial antibiotic susceptibility.
AID520875	Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus saprophyticus isolates isolated from genitourinary tracts of acute cystitis patient after 24 hrs at 35 degC by agar dilution method	2008	Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6	Methicillin-resistant Staphylococcus saprophyticus isolates carrying staphylococcal cassette chromosome mec have emerged in urogenital tract infections.
AID278247	Antimicrobial activity against Salmonella enterica serovar Typhimurium S21-4 tolC::Kan with GyrA S83F, ParC S80I mutation	2007	Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2	Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials.
AID1627349	Antibacterial activity against Acinetobacter baumannii ATCC BAA-1710D assessed as bacterial growth inhibition after 8 hrs by turbidimetric plate reader method	2016	Bioorganic & medicinal chemistry letters, 08-15, Volume: 26, Issue:16	1α,2α-Epoxy-3β-hydroxy oleanolic acid derivatives regulation of the metabolism, haemolysis and β-lactamase gene expression in vitro and their structure-microbicidal activity relationship.
AID424828	Antibacterial activity against kanamycin-resistant and fusidic acid-susceptible Staphylococcus aureus AH290 harboring duplication mutation at nucleotide 202-293 in rplF gene after 18 to 24 hrs by Etest strip assay	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID1164945	Antimicrobial activity against methicillin-resistant Staphylococcus aureus NRS 70 by microbroth dilution method	2014	Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20	Synthesis, structure-activity relationship studies, and antibacterial evaluation of 4-chromanones and chalcones, as well as olympicin A and derivatives.
AID1653586	Anti-leprotic activity against Mycobacterium leprae infected in BALB/c weanling mouse assessed as bacteria killing at 100 mg/kg, ip administrated for 60 days and measured after 1 year by Spearman-Karber technique analysis relative to control	2019	Bioorganic & medicinal chemistry, 07-01, Volume: 27, Issue:13	Insights of synthetic analogues of anti-leprosy agents.
AID585015	Antibacterial activity against Staphylococcus aureus ATCC 29213	2011	Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1	Inhibition of bacterial multidrug resistance by celecoxib, a cyclooxygenase-2 inhibitor.
AID1254280	Antimycobacterial activity against Mycobacterium tuberculosis H37Rv in 7H9/ADC/Tween medium measured at day 14 by Alamar Blue assay	2015	Bioorganic & medicinal chemistry, Nov-15, Volume: 23, Issue:22	Aminopyrazolo[1,5-a]pyrimidines as potential inhibitors of Mycobacterium tuberculosis: Structure activity relationships and ADME characterization.
AID326546	Antimicrobial activity against Mycobacterium abscessus R61 isolate after 3 to 5 days by broth microdilution method	2007	Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5	In Vitro activities of isepamicin, other aminoglycosides, and capreomycin against clinical isolates of rapidly growing mycobacteria in Taiwan.
AID311448	Antitubercular activity against Mycobacterium tuberculosis H37Ra by alamar blue microplate assay	2007	Journal of natural products, Sep, Volume: 70, Issue:9	Antimalarial and antituberculous poly-O-acylated jatrophane diterpenoids from Pedilanthus tithymaloides.
AID509450	Antibacterial activity against Bacillus subtilis after 24 hrs by MTT assay	2010	European journal of medicinal chemistry, Sep, Volume: 45, Issue:9	Design and synthesis of potent inhibitors of beta-ketoacyl-acyl carrier protein synthase III (FabH) as potential antibacterial agents.
AID424574	Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH369 (SCV-41) harboring Gln115Leu mutation in fusA gene after 18 to 24 hrs by Etest strip assay	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID584327	Antibacterial activity against speE deficient Escherichia coli JW0117-1	2010	Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12	Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics.
AID257551	Antibacterial activity against Klebsiella pneumoniae	2005	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 15, Issue:23	Synthesis and biological evaluation of novel (L)-alpha-amino acid methyl ester, heteroalkyl, and aryl substituted 1,4-naphthoquinone derivatives as antifungal and antibacterial agents.
AID1861192	Antimycobacterial activity against drug-sensitive Mycobacterium tuberculosis assessed as mycobacterial growth inhibition	2022	Bioorganic & medicinal chemistry letters, 09-01, Volume: 71	Discovery and preclinical profile of sudapyridine (WX-081), a novel anti-tuberculosis agent.
AID610008	Antibacterial activity against Staphylococcus aureus ATCC6538 after 24 hrs by MTT assay	2011	Bioorganic & medicinal chemistry, Aug-01, Volume: 19, Issue:15	Synthesis, molecular modeling and biological evaluation of β-ketoacyl-acyl carrier protein synthase III (FabH) as novel antibacterial agents.
AID492159	Antimicrobial activity against Staphylococcus aureus ATCC 6538 at 100 ug/well after 24 hrs at 37 degC by agar diffusion assay	2010	Journal of natural products, Jul-23, Volume: 73, Issue:7	Cellular localization of clathridimine, an antimicrobial 2-aminoimidazole alkaloid produced by the Mediterranean calcareous sponge Clathrina clathrus.
AID1593376	Inhibition of Pks13 D1644G/N1640K double mutant thioesterase domain in extensively drug-resistant Mycobacterium tuberculosis TF274 assessed as reduction in bacterial growth by microplate alamar blue assay	2019	Journal of medicinal chemistry, 04-11, Volume: 62, Issue:7	Identification of Novel Coumestan Derivatives as Polyketide Synthase 13 Inhibitors against Mycobacterium tuberculosis. Part II.
AID283546	Antibacterial activity against Pseudomonas aeruginosa KJ7106 with inactivated PA5471 gene by microdilution method	2007	Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3	Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides.
AID1624151	Antitubercular activity against multidrug-resistant Mycobacterium tuberculosis isolate 3 after 7 days	2019	European journal of medicinal chemistry, Feb-15, Volume: 164	Synthesis and evaluation of α-aminoacyl amides as antitubercular agents effective on drug resistant tuberculosis.
AID326539	Antimicrobial activity against Mycobacterium abscessus NTU445 isolate after 3 to 5 days by broth microdilution method	2007	Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5	In Vitro activities of isepamicin, other aminoglycosides, and capreomycin against clinical isolates of rapidly growing mycobacteria in Taiwan.
AID1287980	Antibacterial activity against Bacillus subtilis after 18 hrs by broth dilution method	2016	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 26, Issue:7	Facile synthesis of 1,3-thiazolidin-4-ones as antitubercular agents.
AID381180	Antibacterial activity against Staphylococcus aureus after 24 to 72 hrs by disk diffusion method	1999	Journal of natural products, Sep, Volume: 62, Issue:9	Antimicrobial and antitumor activities of mycosporulone.
AID1905562	Antimicrobial activity against Bacillus subtilis ATCC 23857 assessed as reduction of bacterial growth incubated for 18 hrs by CLSI protocol based broth microdilution method	2022	Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7	Novel β-Hairpin Antimicrobial Peptides Containing the β-Turn Sequence of -RRRF- Having High Cell Selectivity and Low Incidence of Drug Resistance.
AID604258	Antibacterial activity against Bacillus subtilis ATCC 6633 after 24 hrs by MTT colorimetric method	2011	Bioorganic & medicinal chemistry, Jul-01, Volume: 19, Issue:13	4-alkoxy-3-arylfuran-2(5H)-ones as inhibitors of tyrosyl-tRNA synthetase: synthesis, molecular docking and antibacterial evaluation.
AID584333	Antibacterial activity against wild type Escherichia coli BW25113 absence of glutathione	2010	Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12	Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics.
AID524263	Antibacterial activity against Escherichia coli NKE127 harboring deletion mutation in acrB and cpxAR protein	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Effect of NlpE overproduction on multidrug resistance in Escherichia coli.
AID278236	Antimicrobial activity against Salmonella enterica serovar Typhimurium S21-2 with GyrA S83F, ParC S80I mutation	2007	Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2	Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials.
AID278542	Antimicrobial activity against 60 min 1 M HCl-stressed Bifidobacterium longum P/N 601377 after 18 hrs	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID203329	Antibacterial activity expressed as MIC value was determined on Serratia marcescens A-20019 organism	1986	Journal of medicinal chemistry, May, Volume: 29, Issue:5	Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin.
AID587761	Antimicrobial activity against wild type Mycobacterium ulcerans ATCC 19423 infected BALB/c mouse assessed as delay to time to foodpad swelling	2011	Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1	Using bioluminescence to monitor treatment response in real time in mice with Mycobacterium ulcerans infection.
AID1182136	Antitubercular activity against Mycobacterium smegmatis by checkerboard assay in presence of chlorpromazine	2014	Bioorganic & medicinal chemistry, Aug-15, Volume: 22, Issue:16	Pharmacologically active metabolites, combination screening and target identification-driven drug repositioning in antituberculosis drug discovery.
AID68016	Antibacterial activity expressed as MIC value was determined on Enterobacter cloacae A-21006 organism	1986	Journal of medicinal chemistry, May, Volume: 29, Issue:5	Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin.
AID424567	Antibacterial activity against fusidic acid-resistant Staphylococcus aureus AH204 harboring deletion of nucleotide 203-231 in rplF gene after 18 to 24 hrs by Etest strip assay	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID521592	Antibacterial activity against Salmonella enterica serovars virchow isolate 101591 at pH 7.0 by broth dilution method	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	Aminoglycosides affect intracellular Salmonella enterica serovars typhimurium and virchow.
AID163060	Minimum inhibitory concentration was measured against Proteus rettgeri A 9637	1980	Journal of medicinal chemistry, Jan, Volume: 23, Issue:1	Aminoglycoside antibiotics. 3. Epimino derivatives of neamine, ribostamycin, and kanamycin B.
AID749376	Antimicrobial activity against Bacillus subtilis ATCC 530 after 24 hrs by two fold serial dilution method	2013	Bioorganic & medicinal chemistry, Jun-01, Volume: 21, Issue:11	Design, synthesis and antimicrobial activities evaluation of Schiff base derived from secnidazole derivatives as potential FabH inhibitors.
AID1730992	Antitubercular activity against multi drug resistance Mycobacterium tuberculosis V2475 by MABA assay	2021	European journal of medicinal chemistry, Mar-05, Volume: 213	Design and synthesis of mycobacterial pks13 inhibitors: Conformationally rigid tetracyclic molecules.
AID1617681	Antimicrobial activity against Enterococcus faecalis ATCC 29212 by CLSI based two-fold serial dilution method
AID278232	Antimicrobial activity against Salmonella enterica serovar Typhimurium S21-1 GyrA S83F mutant	2007	Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2	Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials.
AID1869569	Antibacterial activity against Klebsiella oxytoca DSM 5175 assessed as reduction in bacterial growth measured after 3 days by broth microdilution method	2022	Journal of natural products, 06-24, Volume: 85, Issue:6	Triculamin: An Unusual Lasso Peptide with Potent Antimycobacterial Activity.
AID1132229	Antibacterial activity against streptomycin, neomycin, kanamycin, gentamicin-resistant Escherichia coli 2964 assessed as growth inhibition by agar dilution method	1978	Journal of medicinal chemistry, Feb, Volume: 21, Issue:2	Chemical modification of 1,4-diamino-1,4-dideoxy-3-O-(4-deoxy-4-propionamido-alpha-D-glucopyranosyl)-D-glucitol.
AID93906	Minimum inhibitory concentration (MIC) was measured against Klebsiella pneumoniae.	1995	Journal of medicinal chemistry, Nov-10, Volume: 38, Issue:23	Synthesis and antimicrobial and toxicological studies of amino acid and peptide derivatives of kanamycin A and netilmicin.
AID1890918	Antimicrobial activity against Bacillus subtilis ATCC 23857 assessed as inhibition of microbial growth incubated for 16 hrs under shaking condition by microdilution assay	2022	Journal of natural products, 04-22, Volume: 85, Issue:4	Expanding the Chemical Diversity of Fasamycin Via Genome Mining and Biocatalysis.
AID670727	Antibacterial activity against Escherichia coli ATCC 25922/35128 after 24 hrs by MTT assay	2012	Bioorganic & medicinal chemistry, Jul-15, Volume: 20, Issue:14	Design, synthesis and antimicrobial activities of nitroimidazole derivatives containing 1,3,4-oxadiazole scaffold as FabH inhibitors.
AID67885	Minimum inhibitory concentration (MIC) was measured against Enterococcus faecalis ATCC 29212.	1995	Journal of medicinal chemistry, Nov-10, Volume: 38, Issue:23	Synthesis and antimicrobial and toxicological studies of amino acid and peptide derivatives of kanamycin A and netilmicin.
AID1565720	Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 incubated for 18 hrs by two fold dilution method	2019	European journal of medicinal chemistry, Nov-15, Volume: 182	Scalable and cost-effective tosylation-mediated synthesis of antifungal and fungal diagnostic 6″-Modified amphiphilic kanamycins.
AID625287	Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatomegaly	2011	PLoS computational biology, Dec, Volume: 7, Issue:12	Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID278802	Antimicrobial activity against recombinant Escherichia coli DH5-alpha expressing pBAD in the presence of arabinose	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Aph(3')-IIc, an aminoglycoside resistance determinant from Stenotrophomonas maltophilia.
AID278521	Antimicrobial activity against Bifidobacterium animalis ATCC 27536	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID1348083	Antimicrobial activity against Candida parapsilosis ATCC 90018 assessed as zone of inhibition at 50 ug per disc after 48 hrs by disc diffusion assay	2018	European journal of medicinal chemistry, Jan-01, Volume: 143	Synthesis of new 1-benzyl tetrahydropyridinylidene ammonium salts and their antimicrobial and anticellular activities.
AID1079944	Benign tumor, proven histopathologically. Value is number of references indexed. [column 'T.BEN' in source]
AID278543	Antimicrobial activity against 60 min 1 M HCl-stressed Bifidobacterium pseudolongum ATCC 25562 after 18 hrs	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID1629134	Inhibition of cytosolic eukaryotic translation in rabbit reticulocyte S30 extract measured after 60 mins by coupled transcription/translation-based luciferase reporter gene assay	2016	Journal of medicinal chemistry, 09-08, Volume: 59, Issue:17	Effects of 5-O-Ribosylation of Aminoglycosides on Antimicrobial Activity and Selective Perturbation of Bacterial Translation.
AID1077160	Inhibition of Escherichia coli FabH expressed in Escherichia coli BL21 (DE3) after 25 mins	2014	European journal of medicinal chemistry, Apr-09, Volume: 76	Design and synthesis of 2-styryl of 5-Nitroimidazole derivatives and antimicrobial activities as FabH inhibitors.
AID1265786	Antibacterial activity against Listeria monocytogenes ATCC 19115 by microdilution method	2015	Journal of medicinal chemistry, Dec-10, Volume: 58, Issue:23	Synthesis and Bioactivities of Kanamycin B-Derived Cationic Amphiphiles.
AID369073	Antimicrobial activity against Escherichia coli ATCC 35218 after 24 hrs by MTT assay	2009	Bioorganic & medicinal chemistry, Feb-01, Volume: 17, Issue:3	Synthesis, structure and antibacterial activity of new 2-(1-(2-(substituted-phenyl)-5-methyloxazol-4-yl)-3-(2-substitued-phenyl)-4,5-dihydro-1H-pyrazol-5-yl)-7-substitued-1,2,3,4-tetrahydroisoquinoline derivatives.
AID1869562	Bactericidal activity against Mycobacterium smegmatis DSM 43080 assessed as reduction in colony count and measured after 3 days by agar diffusion assay	2022	Journal of natural products, 06-24, Volume: 85, Issue:6	Triculamin: An Unusual Lasso Peptide with Potent Antimycobacterial Activity.
AID283534	Antibacterial activity against Pseudomonas aeruginosa FE57 containing inactivated rplY gene with pARAL25 by microdilution method	2007	Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3	Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides.
AID1359443	Antibacterial activity against Escherichia coli NCIM 2688 after 8 hrs by serial dilution method	2018	European journal of medicinal chemistry, May-25, Volume: 152	Antibacterial and anti-TB tat-peptidomimetics with improved efficacy and half-life.
AID544276	Antimicrobial activity against Enterococcus faecalis NKH6 harboring pMG2200-like and pMG2201-like plasmids after 24 hrs by agar dilution method	2009	Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2	Isolation of VanB-type Enterococcus faecalis strains from nosocomial infections: first report of the isolation and identification of the pheromone-responsive plasmids pMG2200, Encoding VanB-type vancomycin resistance and a Bac41-type bacteriocin, and pMG2
AID424343	Antibacterial activity against fusidic acid-resistant Staphylococcus aureus AH206 harboring Arg464Ser mutation in fusA gene after 18 to 24 hrs by Etest strip assay	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID424597	Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH339 (SCV-11) harboring -1 frameshift mutation at nucleotide 144 in rplF gene after 18 to 24 hrs by Etest strip assay	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID278528	Antimicrobial activity against Bifidobacterium longum ATCC 15708	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID610007	Antibacterial activity against Bacillus subtilis ATCC6633 after 24 hrs by MTT assay	2011	Bioorganic & medicinal chemistry, Aug-01, Volume: 19, Issue:15	Synthesis, molecular modeling and biological evaluation of β-ketoacyl-acyl carrier protein synthase III (FabH) as novel antibacterial agents.
AID1491155	Antibacterial activity against Enterococcus faecalis ATCC 29212 by CLSI method	2017	Journal of natural products, 05-26, Volume: 80, Issue:5	Antimicrobial Spirotetronate Metabolites from Marine-Derived Micromonospora harpali SCSIO GJ089.
AID424829	Antibacterial activity against kanamycin-resistant and fusidic acid-susceptible Staphylococcus aureus AH420 harboring deletion of nucleotide 72-80 in rplF gene after 18 to 24 hrs by Etest strip assay	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID293858	Antibacterial activity against methicillin-resistant Staphylococcus aureus CMAH 0430 after 24 hrs by two fold dilution method	2007	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6	Synthesis of pseudopeptides based L-tryptophan as a potential antimicrobial agent.
AID387746	Binding affinity to yeast tRNAPhe by quantitative ribonuclease V1 footprinting assay	2008	Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19	Screening helix-threading peptides for RNA binding using a thiazole orange displacement assay.
AID404896	Antibacterial activity against high-level gentamicin resistant Streptococcus pasteurianus SB28 isolate carrying transposon-borne resistance gene [aac(6')Ie-aph(2'')Ia] by agar dilution method	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	High-level gentamicin resistance mediated by a Tn4001-like transposon in seven nonclonal hospital isolates of Streptococcus pasteurianus.
AID1326385	Antibacterial activity against Bacillus subtilis P10A derived after 10 passage in presence of JBIR-100 after 16 to 18 hrs by microbroth dilution assay	2016	Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24	Biological characterization of the hygrobafilomycin antibiotic JBIR-100 and bioinformatic insights into the hygrolide family of natural products.
AID521596	Antibacterial activity against Salmonella enterica serovars Typhimurium ATCC 14028 at pH 7.0 by bioluminescence assay	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	Aminoglycosides affect intracellular Salmonella enterica serovars typhimurium and virchow.
AID207043	Antibacterial activity expressed as MIC value was determined on Staphylococcus aureus A-9537 organism	1986	Journal of medicinal chemistry, May, Volume: 29, Issue:5	Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin.
AID1740925	Inhibition of human Cx26 expressed in Escherichia coli LB2003 cells in medium containing 4 mM K+ and 500 uM IPTG by measuring cell growth after 18 hrs by plate reader	2020	European journal of medicinal chemistry, Oct-01, Volume: 203	Amphiphilic aminoglycosides with increased selectivity for inhibition of connexin 43 (Cx43) hemichannels.
AID1056541	Antibacterial activity against Escherichia coli ATCC 25922 by broth microdilution method	2013	Journal of natural products, Dec-27, Volume: 76, Issue:12	Cytotoxic and antibacterial marfuraquinocins from the deep South China Sea-derived Streptomyces niveus SCSIO 3406.
AID1566486	Binding affinity to biotinylated pre-miRNA-21 (unknown origin) by SPR analysis	2019	ACS medicinal chemistry letters, May-09, Volume: 10, Issue:5	Tetracyclines as Inhibitors of Pre-microRNA Maturation: A Disconnection between RNA Binding and Inhibition.
AID424608	Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH386 (SCV-58) harboring -1 frameshift mutation at nucleotide 90 in rplF gene after 18 to 24 hrs by Etest strip assay	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID774295	Antimycobacterial activity against kanamycin-resistant Mycobacterium tuberculosis ATCC 35827	2013	Journal of natural products, Oct-25, Volume: 76, Issue:10	Chlorinated coumarins from the polypore mushroom Fomitopsis officinalis and their activity against Mycobacterium tuberculosis.
AID1482267	Antibacterial activity against Escherichia coli MG1655 measured every 15 mins for 12 hrs	2017	Journal of medicinal chemistry, 05-11, Volume: 60, Issue:9	Prediction of Antibiotic Interactions Using Descriptors Derived from Molecular Structure.
AID278229	Antimicrobial activity against Salmonella enterica serovar Typhimurium S21 gyrA+	2007	Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2	Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials.
AID1413326	Antifungal activity against Candida pseudotropicalis YOGI	2018	MedChemComm, Jun-01, Volume: 9, Issue:6	Antifungal amphiphilic kanamycins: new life for an old drug.
AID1287401	Antimicrobial activity against Staphylococcus epidermidis after 24 hrs by serial two-fold microbroth dilution method	2016	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 26, Issue:6	One-pot synthesis and antimicrobial evaluation of novel 3-cyanopyridine derivatives of (-)-β-pinene.
AID1132226	Antibacterial activity against Streptococcus faecalis 755 assessed as growth inhibition by agar dilution method	1978	Journal of medicinal chemistry, Feb, Volume: 21, Issue:2	Chemical modification of 1,4-diamino-1,4-dideoxy-3-O-(4-deoxy-4-propionamido-alpha-D-glucopyranosyl)-D-glucitol.
AID278565	Antimicrobial activity against 90 mins hydrogen peroxide-stressed Bifidobacterium longum R0175 after 18 hrs	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID424833	Ratio of MIC for kanamycin-resistant Staphylococcus aureus harboring mutations in FusA gene to MIC for wild type kanamycin-susceptible Staphylococcus aureus AH001	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID544058	Antimicrobial activity against Shigella flexneri isolate C506 harboring sul1 to sul3 genes assessed as antibiotic resistance breakpoint by agar dilution method	2009	Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2	Prevalence of sulfonamide resistance genes in bacterial isolates from manured agricultural soils and pig slurry in the United Kingdom.
AID1557265	Antitubercular activity against resistant Mycobacterium tuberculosis harboring rrs C1402T mutant after 3 to 6 weeks	2019	MedChemComm, Aug-01, Volume: 10, Issue:8	Drug-resistance in
AID524384	Antibacterial activity against Escherichia coli NKE126 harboring deletion mutation in acrB and acrD protein	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Effect of NlpE overproduction on multidrug resistance in Escherichia coli.
AID424583	Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH347 (SCV-19) harboring Arg659Ser mutation in fusA gene after 18 to 24 hrs by Etest strip assay	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID1695863	Antibacterial activity against Pseudomonas fluorescens NCIM 2173 incubated for 24 hrs	2019	European journal of medicinal chemistry, Apr-15, Volume: 168	Comprehensive review on the anti-bacterial activity of 1,2,3-triazole hybrids.
AID582763	Antimicrobial activity against eaeA positive verocytotoxin-producing non-O157 Escherichia coli isolates obtained from human assessed as percentage of resistant isolates	2010	Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11	Antimicrobial resistance testing of verocytotoxin-producing Escherichia coli and first description of TEM-52 extended-spectrum β-lactamase in serogroup O26.
AID1132230	Antibacterial activity against Pseudomonas aeruginosa 2956 assessed as growth inhibition by agar dilution method	1978	Journal of medicinal chemistry, Feb, Volume: 21, Issue:2	Chemical modification of 1,4-diamino-1,4-dideoxy-3-O-(4-deoxy-4-propionamido-alpha-D-glucopyranosyl)-D-glucitol.
AID424582	Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH331 (SCV-3) harboring Arg659His mutation in fusA gene after 18 to 24 hrs by Etest strip assay	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID1638887	Antimicrobial activity against Staphylococcus aureus at 0.5 to 256 ug/ml after 24 hrs by two-fold serial micro dilution method	2019	Journal of natural products, 04-26, Volume: 82, Issue:4	Inducing Secondary Metabolite Production by Co-culture of the Endophytic Fungus Phoma sp. and the Symbiotic Fungus Armillaria sp.
AID295897	Antibacterial activity against Bacillus subtilis ATCC 6633 after 24 hrs by MTT method	2007	Bioorganic & medicinal chemistry, Jun-15, Volume: 15, Issue:12	Synthesis, structure, and structure-activity relationship analysis of enamines as potential antibacterials.
AID477411	Antibacterial activity against MBX-1090-resistant Staphylococcus aureus isolate d20A1 after 16 to 20 hrs by broth microdilution method	2010	Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6	Efflux-mediated bis-indole resistance in Staphylococcus aureus reveals differential substrate specificities for MepA and MepR.
AID565231	Antimicrobial activity against Mycobacterium chelonae 9917 harboring pZS01 carrying mspA gene by resazurine microtiter assay	2009	Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9	Role of porins in the susceptibility of Mycobacterium smegmatis and Mycobacterium chelonae to aldehyde-based disinfectants and drugs.
AID441925	Antibacterial activity against Micrococcus luteus WT after 24 hrs by NCCLS method	2009	Journal of medicinal chemistry, Nov-12, Volume: 52, Issue:21	Coordination chemistry based approach to lipophilic inhibitors of 1-deoxy-D-xylulose-5-phosphate reductoisomerase.
AID601494	Antibacterial activity against Bacillus subtilis MTCC 441 at 30 ug/disc after 24 hrs	2011	European journal of medicinal chemistry, Jun, Volume: 46, Issue:6	Evaluation of antioxidant and antimicrobial activities of Bergenin and its derivatives obtained by chemoenzymatic synthesis.
AID1562316	Antimycobacterial activity against Mycobacterium smegmatis atR37 assessed as decrease in drug resistance development at 5 ug/disc after 2 to 3 days by paper disc method	2019	European journal of medicinal chemistry, Sep-15, Volume: 178	Synthesis and antimycobacterial activity of imidazo[1,2-b][1,2,4,5]tetrazines.
AID257554	Antibacterial activity against Staphylococcus aureus	2005	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 15, Issue:23	Synthesis and biological evaluation of novel (L)-alpha-amino acid methyl ester, heteroalkyl, and aryl substituted 1,4-naphthoquinone derivatives as antifungal and antibacterial agents.
AID278246	Antimicrobial activity against Salmonella enterica serovar Typhimurium S21-4 acrAB::Kan with GyrA S83F, ParC S80I mutation	2007	Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2	Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials.
AID368421	Antimicrobial activity against Escherichia coli KAM32 pSTV28 containing chloramphenicol-resistant vector by agar dilution method	2007	Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9	New plasmid-mediated fluoroquinolone efflux pump, QepA, found in an Escherichia coli clinical isolate.
AID203165	Minimum inhibitory concentration measured against Serratia marcescens	1995	Journal of medicinal chemistry, Nov-10, Volume: 38, Issue:23	Synthesis and antimicrobial and toxicological studies of amino acid and peptide derivatives of kanamycin A and netilmicin.
AID1202740	Antimicrobial activity against Escherichia coli assessed as reduction in bacterial growth incubated for 48 hrs by microbroth dilution method	2015	Journal of natural products, Feb-27, Volume: 78, Issue:2	Prenylated benzophenones from Triadenum japonicum.
AID523001	Cytotoxicity against human 5637 cells assessed as mild induction of cell death by trypan blue exclusion assay	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Persistence of uropathogenic Escherichia coli in the face of multiple antibiotics.
AID1194692	Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 33591 assessed as inhibition of microbial growth at 0.064 ug/ml to 125 ug/ml incubated at 37 degC for 20 hrs	2015	Bioorganic & medicinal chemistry letters, May-01, Volume: 25, Issue:9	Three new fusidic acid derivatives and their antibacterial activity.
AID551749	Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 after 12 to 18 hrs by twofold dilution method	2011	Bioorganic & medicinal chemistry, Jan-01, Volume: 19, Issue:1	Synthesis and antibacterial activity study of a novel class of cationic anthraquinone analogs.
AID278238	Antimicrobial activity against Salmonella enterica serovar Typhimurium S21-2 acrAB::Kan with GyrA S83F, ParC S80I mutation	2007	Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2	Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials.
AID278535	Antimicrobial activity against 60 min 1 M HCl-stressed Bifidobacterium bifidum R0071 after 18 hrs	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID771509	Antibacterial activity against community associated methicillin-resistant Staphylococcus aureus USA300 by dilution technique	2013	European journal of medicinal chemistry, Oct, Volume: 68	Synthesis and biological evaluation of novel ocotillol-type triterpenoid derivatives as antibacterial agents.
AID1132233	Antibacterial activity against streptomycin, neomycin, kanamycin, gentamicin, tobramycin-resistant Klebsiella 2922 assessed as growth inhibition by agar dilution method	1978	Journal of medicinal chemistry, Feb, Volume: 21, Issue:2	Chemical modification of 1,4-diamino-1,4-dideoxy-3-O-(4-deoxy-4-propionamido-alpha-D-glucopyranosyl)-D-glucitol.
AID404898	Antibacterial activity against high-level gentamicin resistant Streptococcus pasteurianus SB33 isolate carrying transposon-borne resistance gene [aac(6')Ie-aph(2'')Ia] by agar dilution method	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	High-level gentamicin resistance mediated by a Tn4001-like transposon in seven nonclonal hospital isolates of Streptococcus pasteurianus.
AID1436939	Antibacterial activity against Escherichia coli ATCC 25292 after 8 hrs	2017	Bioorganic & medicinal chemistry letters, 02-15, Volume: 27, Issue:4	Quinolidene based monocarbonyl curcumin analogues as promising antimycobacterial agents: Synthesis and molecular docking study.
AID1491151	Antibacterial activity against Bacillus subtilis BS01 by CLSI method	2017	Journal of natural products, 05-26, Volume: 80, Issue:5	Antimicrobial Spirotetronate Metabolites from Marine-Derived Micromonospora harpali SCSIO GJ089.
AID1868101	Antibacterial activity against Micrococcus luteus ATCC 9341 assessed as inhibition of visible bacterial growth incubated for 18 hrs by CLSI protocol based assay	2022	Journal of natural products, 05-27, Volume: 85, Issue:5	Enceleamycins A-C, Furo-Naphthoquinones from
AID1710554	Displacement of F-neo from premature miRNA21 (unknown origin) at 100 nM by fluorescence assay relative to control	2018	MedChemComm, Jul-01, Volume: 9, Issue:7	Targeting miRNA by tunable small molecule binders: peptidic aminosugar mediated interference in miR-21 biogenesis reverts epithelial to mesenchymal transition.
AID1585677	Antibiofilm activity against methicillin-resistant Staphylococcus aureus planktonic biofilm assessed as optical density at 492 nm at MIC after 24 hrs by crystal violet staining-based UV-visible spectrophotometric analysis	2019	European journal of medicinal chemistry, Jan-15, Volume: 162	Discovery of novel arylethenesulfonyl fluorides as potential candidates against methicillin-resistant of Staphylococcus aureus (MRSA) for overcoming multidrug resistance of bacterial infections.
AID368420	Antimicrobial activity against Escherichia coli KAM32 pHPA containing mutated GyrA gene by agar dilution method	2007	Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9	New plasmid-mediated fluoroquinolone efflux pump, QepA, found in an Escherichia coli clinical isolate.
AID1629127	Antimicrobial activity against Klebsiella pneumoniae ATCC 10031 measured after 24 hrs by double-dilution method	2016	Journal of medicinal chemistry, 09-08, Volume: 59, Issue:17	Effects of 5-O-Ribosylation of Aminoglycosides on Antimicrobial Activity and Selective Perturbation of Bacterial Translation.
AID486725	Antibacterial activity against Bacillus subtilis ATCC 6633 after 24 hrs by MTT assay	2010	European journal of medicinal chemistry, Jun, Volume: 45, Issue:6	Synthesis, structure and structure-activity relationship analysis of caffeic acid amides as potential antimicrobials.
AID1663464	Antibacterial activity against Bacillus subtilis ATCC 6633 incubated for 16 hrs by broth microdilution method	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Antibacterial Pentacyclic Polyketides from a Soil-Derived
AID1869573	Antibacterial activity against Pseudomonas aeruginosa DSM 19880 assessed as reduction in bacterial growth measured after 3 days by broth microdilution method	2022	Journal of natural products, 06-24, Volume: 85, Issue:6	Triculamin: An Unusual Lasso Peptide with Potent Antimycobacterial Activity.
AID529885	Antibacterial activity against Staphylococcus aureus RN4220 by broth microdilution method	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Discovery and characterization of QPT-1, the progenitor of a new class of bacterial topoisomerase inhibitors.
AID1710563	Antibacterial activity against Staphylococcus aureus ATCC 25923 assessed as reduction in bacterial growth incubated for 15 to 20 hrs by broth microdilution method	2018	MedChemComm, Jul-01, Volume: 9, Issue:7	Targeting miRNA by tunable small molecule binders: peptidic aminosugar mediated interference in miR-21 biogenesis reverts epithelial to mesenchymal transition.
AID1303881	Antibacterial activity against multidrug resistant Enterococcus faecium NCTC 7171 (ATCC 19434) assessed as reduction in bacterial growth incubated for 6 to 8 hrs	2016	Bioorganic & medicinal chemistry letters, 07-01, Volume: 26, Issue:13	GroEL/ES inhibitors as potential antibiotics.
AID1359445	Antibacterial activity against Enterobacter sp. NCIM 5392 after 8 hrs by serial dilution method	2018	European journal of medicinal chemistry, May-25, Volume: 152	Antibacterial and anti-TB tat-peptidomimetics with improved efficacy and half-life.
AID207038	Antibacterial activity expressed as MIC value was determined on Staphylococcus aureus A-20240 organism	1986	Journal of medicinal chemistry, May, Volume: 29, Issue:5	Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin.
AID1296449	Antimycobacterial activity against Mycobacterium tuberculosis H37Ra assessed as growth inhibition at 5 ug/ml preincubated for 1 hr followed by radiolabeling with [14C]-uracil, [14C]-methionine for 24 hrs	2016	Journal of medicinal chemistry, Mar-24, Volume: 59, Issue:6	Development of 3,5-Dinitrobenzylsulfanyl-1,3,4-oxadiazoles and Thiadiazoles as Selective Antitubercular Agents Active Against Replicating and Nonreplicating Mycobacterium tuberculosis.
AID1861191	Antimycobacterial activity against multidrug-resistant Mycobacterium tuberculosis assessed as mycobacterial growth inhibition	2022	Bioorganic & medicinal chemistry letters, 09-01, Volume: 71	Discovery and preclinical profile of sudapyridine (WX-081), a novel anti-tuberculosis agent.
AID586085	Antimicrobial activity against verocytotoxin-producing Escherichia coli isolate O157 obtained from human assessed as percentage of resistant isolates by disk diffusion method	2010	Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11	Antimicrobial resistance testing of verocytotoxin-producing Escherichia coli and first description of TEM-52 extended-spectrum β-lactamase in serogroup O26.
AID1869564	Bactericidal activity against Bacillus cereus DSM 31 assessed as reduction in colony count and measured after 3 days by agar diffusion assay	2022	Journal of natural products, 06-24, Volume: 85, Issue:6	Triculamin: An Unusual Lasso Peptide with Potent Antimycobacterial Activity.
AID750185	Antibacterial activity against Escherichia coli ATCC 35218 assessed as growth inhibition after 24 hrs by two-fold serial dilution method	2013	European journal of medicinal chemistry, Jun, Volume: 64	Synthesis and antimicrobical evaluation of a novel class of 1,3,4-thiadiazole: derivatives bearing 1,2,4-triazolo[1,5-a]pyrimidine moiety.
AID563511	Antimicrobial activity against cetylpyridinium chloride-resistant Serratia marcescens HMS011 harboring plasmid STV28 expressing sdeB gene by broth dilution method	2009	Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12	Mutational upregulation of a resistance-nodulation-cell division-type multidrug efflux pump, SdeAB, upon exposure to a biocide, cetylpyridinium chloride, and antibiotic resistance in Serratia marcescens.
AID299666	Antibacterial activity against Micrococcus luteus CMCC(B)28001 by broth microdilution method	2007	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 17, Issue:15	Synthesis and evaluation of amphiphilic cationic quinine-derived for antibacterial activity against methicillin-resistant Staphylococcus aureus.
AID1539487	Antibacterial activity against Salmonella enteritidis ATCC 14028 infected in mouse J774 cells assessed as reduction in intracellular bacterial cells at 2 times MIC incubated for 24 hrs followed by re-plating on TSA plate and measured after 18 to 22 hrs re
AID1869568	Bactericidal activity against Staphylococcus aureus DSM 20231 assessed as reduction in colony count and measured after 3 days by agar diffusion assay	2022	Journal of natural products, 06-24, Volume: 85, Issue:6	Triculamin: An Unusual Lasso Peptide with Potent Antimycobacterial Activity.
AID1478520	Ratio of MIC for aminoglycosides-resistant Escherichia coli BL21 harboring pET11d encode for APH(3')-2b resistance enzyme to MIC for Escherichia coli BL21	2017	Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11	Covalently linked kanamycin - Ciprofloxacin hybrid antibiotics as a tool to fight bacterial resistance.
AID1413335	Antifungal activity against resistant Candida parapsilosis	2018	MedChemComm, Jun-01, Volume: 9, Issue:6	Antifungal amphiphilic kanamycins: new life for an old drug.
AID1348086	Antimicrobial activity against Staphylococcus epidermidis ATCC 12228 assessed as zone of inhibition at 50 ug per disc after 24 hrs by disc diffusion assay	2018	European journal of medicinal chemistry, Jan-01, Volume: 143	Synthesis of new 1-benzyl tetrahydropyridinylidene ammonium salts and their antimicrobial and anticellular activities.
AID434368	Antibacterial activity against Klebsiella pneumoniae ATCC 27736 after 24 hrs by broth microdilution method	2009	European journal of medicinal chemistry, Aug, Volume: 44, Issue:8	Design, synthesis and biological evaluation of novel nitrogen and sulfur containing hetero-1,4-naphthoquinones as potent antifungal and antibacterial agents.
AID544274	Antimicrobial activity against Enterococcus faecalis NKH4 harboring pMG2200-like and pMG2201-like plasmids after 24 hrs by agar dilution method	2009	Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2	Isolation of VanB-type Enterococcus faecalis strains from nosocomial infections: first report of the isolation and identification of the pheromone-responsive plasmids pMG2200, Encoding VanB-type vancomycin resistance and a Bac41-type bacteriocin, and pMG2
AID1293898	Antibacterial activity against Escherichia coli after 18 hrs by broth dilution method	2016	Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9	Novel tetrazoloquinoline-rhodanine conjugates: Highly efficient synthesis and biological evaluation.
AID486727	Antibacterial activity against Staphylococcus aureus ATCC 6538 after 24 hrs by MTT assay	2010	European journal of medicinal chemistry, Jun, Volume: 45, Issue:6	Synthesis, structure and structure-activity relationship analysis of caffeic acid amides as potential antimicrobials.
AID573967	Antibacterial activity against Cj1211-negative Campylobacter jejuni harboring aphA3 and tet(O) genes	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Role of Cj1211 in natural transformation and transfer of antibiotic resistance determinants in Campylobacter jejuni.
AID1636440	Drug activation in human Hep3B cells assessed as human CYP2D6-mediated drug metabolism-induced cytotoxicity measured as decrease in cell viability at 300 uM pre-incubated with BSO for 18 hrs followed by incubation with compound for 3 hrs in presence of NA	2016	Bioorganic & medicinal chemistry letters, 08-15, Volume: 26, Issue:16	Development of a cell viability assay to assess drug metabolite structure-toxicity relationships.
AID326549	Antimicrobial activity against Mycobacterium abscessus R49 isolate after 3 to 5 days by broth microdilution method	2007	Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5	In Vitro activities of isepamicin, other aminoglycosides, and capreomycin against clinical isolates of rapidly growing mycobacteria in Taiwan.
AID424581	Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH329 (SCV-1) harboring Arg659Cys mutation in fusA gene after 18 to 24 hrs by Etest strip assay	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID373987	Antimicrobial activity against azide-resistant aac(6')-Ib-cr deficient Escherichia coli J53 qnrA1 bearing pHS4 transconjugant from Enterobacter cloacae 91 by agar dilution method	2007	Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11	Prevalence and expression of the plasmid-mediated quinolone resistance determinant qnrA1.
AID625279	Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for bilirubinemia	2011	PLoS computational biology, Dec, Volume: 7, Issue:12	Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID610005	Antibacterial activity against Escherichia coli ATCC35218 after 24 hrs by MTT assay	2011	Bioorganic & medicinal chemistry, Aug-01, Volume: 19, Issue:15	Synthesis, molecular modeling and biological evaluation of β-ketoacyl-acyl carrier protein synthase III (FabH) as novel antibacterial agents.
AID293873	Antimicrobial activity against Micrococcus luteus CMCC(B) 28001 after 24 hrs by two fold dilution method	2007	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6	Synthesis of pseudopeptides based L-tryptophan as a potential antimicrobial agent.
AID1905563	Antimicrobial activity against Staphylococcus epidermidis ATCC 12228 assessed as reduction of bacterial growth incubated for 18 hrs by CLSI protocol based broth microdilution method	2022	Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7	Novel β-Hairpin Antimicrobial Peptides Containing the β-Turn Sequence of -RRRF- Having High Cell Selectivity and Low Incidence of Drug Resistance.
AID1105399	Antibacterial activity against Staphylococcus aureus MTCC 3160 assessed as growth inhibition at 25 ug/disk after 24 hr by disk diffusion method	2013	European journal of medicinal chemistry, Jan, Volume: 59	Microwave synthesis, characterization and bio-efficacy evaluation of novel chalcone based 6-carbethoxy-2-cyclohexen-1-one and 2H-indazol-3-ol derivatives.
AID1191412	Antimicrobial activity against Staphylococcus aureus PCM 2054 (ATCC 25923) after 16 to 20 hrs by broth micro-dilution method	2015	Bioorganic & medicinal chemistry letters, Feb-01, Volume: 25, Issue:3	In vitro studies of antimicrobial activity of Gly-His-Lys conjugates as potential and promising candidates for therapeutics in skin and tissue infections.
AID599149	Antibacterial activity against Staphylococcus aureus after 24 hrs by MTT assay	2008	European journal of medicinal chemistry, Mar, Volume: 43, Issue:3	Synthesis, crystal structure and antimicrobial activity of deoxybenzoin derivatives from genistein.
AID424595	Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH374 (SCV-46) harboring -5 frameshift mutation at nucleotide 236-240 in rplF gene after 18 to 24 hrs by Etest strip assay	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID1413322	Antibacterial activity against Staphylococcus aureus ATCC 25923	2018	MedChemComm, Jun-01, Volume: 9, Issue:6	Antifungal amphiphilic kanamycins: new life for an old drug.
AID774296	Antimycobacterial activity against streptomycin-resistant Mycobacterium tuberculosis ATCC 35820	2013	Journal of natural products, Oct-25, Volume: 76, Issue:10	Chlorinated coumarins from the polypore mushroom Fomitopsis officinalis and their activity against Mycobacterium tuberculosis.
AID610006	Antibacterial activity against Pseudomonas aeruginosa ATCC13525 after 24 hrs by MTT assay	2011	Bioorganic & medicinal chemistry, Aug-01, Volume: 19, Issue:15	Synthesis, molecular modeling and biological evaluation of β-ketoacyl-acyl carrier protein synthase III (FabH) as novel antibacterial agents.
AID424604	Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH383 (SCV-55) harboring TAA stop codon at nucleotide 139 in rplF gene after 18 to 24 hrs by Etest strip assay	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID532986	Antibacterial activity against Pseudomonas aeruginosa NCIM 5029	2010	Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8	N-acetylcysteine-mediated modulation of bacterial antibiotic susceptibility.
AID551751	Antibacterial activity against vancomycin-resistant Enterococcus faecalis ATCC 51299 after 12 to 18 hrs by twofold dilution method	2011	Bioorganic & medicinal chemistry, Jan-01, Volume: 19, Issue:1	Synthesis and antibacterial activity study of a novel class of cationic anthraquinone analogs.
AID424614	Antibacterial activity against kanamycin-resistant and fusidic acid-susceptible Staphylococcus aureus AH291 harboring Arg659His mutation in fusA gene after 18 to 24 hrs by Etest strip assay	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID145298	Antibacterial activity against Mycobacterium tuberculosis H37Rv.	1985	Journal of medicinal chemistry, Dec, Volume: 28, Issue:12	Synthesis and antibacterial activity of 2,2'-dithiobis(benzamide) derivatives against Mycobacterium species.
AID588212	Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in rodents	2010	Chemical research in toxicology, Jan, Volume: 23, Issue:1	Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
AID532981	Antibacterial activity against Escherichia coli DH5alpha	2010	Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8	N-acetylcysteine-mediated modulation of bacterial antibiotic susceptibility.
AID1585465	Antibacterial activity against Escherichia coli AB1157 measured after 16 hrs	2019	European journal of medicinal chemistry, Jan-15, Volume: 162	Design, synthesis and evaluation of hybrid of tetrahydrocarbazole with 2,4-diaminopyrimidine scaffold as antibacterial agents.
AID1905561	Antimicrobial activity against Staphylococcus aureus ATCC 25923 assessed as reduction of bacterial growth incubated for 18 hrs by CLSI protocol based broth microdilution method	2022	Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7	Novel β-Hairpin Antimicrobial Peptides Containing the β-Turn Sequence of -RRRF- Having High Cell Selectivity and Low Incidence of Drug Resistance.
AID584331	Antibacterial activity against tolC, speE deficient Escherichia coli GD106	2010	Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12	Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics.
AID1265794	Antibacterial activity against Staphylococcus epidermidis ATCC 12228 by microdilution method	2015	Journal of medicinal chemistry, Dec-10, Volume: 58, Issue:23	Synthesis and Bioactivities of Kanamycin B-Derived Cationic Amphiphiles.
AID759041	Antibacterial activity against Bacillus subtilis assessed as survival after 24 hrs by MTT assay	2013	European journal of medicinal chemistry, Jul, Volume: 65	Potentiating 1-(2-hydroxypropyl)-2-styryl-5-nitroimidazole derivatives against antibacterial agents: design, synthesis and biology analysis.
AID278555	Antimicrobial activity against 90 mins oxgall-stressed Bifidobacterium longum P/N 601377 after 18 hrs	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID1413329	Antifungal activity against Candida tropicalis 95-41	2018	MedChemComm, Jun-01, Volume: 9, Issue:6	Antifungal amphiphilic kanamycins: new life for an old drug.
AID1890842	Antimycobacterial activity against wild type Mycobacterium smegmatis mc2 155 assessed as inhibition of mycobacterial growth incubated for 3 to 5 days by resazurin microtiter assay	2022	Bioorganic & medicinal chemistry letters, 05-15, Volume: 64	Design, synthesis and antibacterial activity against pathogenic mycobacteria of conjugated hydroxamic acids, hydrazides and O-alkyl/O-acyl protected hydroxamic derivatives.
AID1562315	Antimycobacterial activity against Mycobacterium smegmatis atR33 assessed as decrease in drug resistance development at 5 ug/disc after 2 to 3 days by paper disc method	2019	European journal of medicinal chemistry, Sep-15, Volume: 178	Synthesis and antimycobacterial activity of imidazo[1,2-b][1,2,4,5]tetrazines.
AID1306201	Antibacterial activity against Staphylococcus aureus ATCC 25923 after 18 hrs by microbroth dilution assay	2016	Bioorganic & medicinal chemistry, 07-15, Volume: 24, Issue:14	The influence of halogen substituents on the biological properties of sulfur-containing flavonoids.
AID405080	Antimicrobial activity against Citrobacter freundii 33587 isolate by agar dilution method	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	Biochemical characterization of PER-2 and genetic environment of blaPER-2.
AID1882861	Antibacterial activity against Escherichia coli K12 expressing modified luxABCDE genes assessed as reduction in bacterial growth by measuring reduction in optical density at 40 uM incubated for 16 hrs by microplate reader analysis	2022	European journal of medicinal chemistry, Jul-05, Volume: 237	The role of the maleimide ring system on the structure-activity relationship of showdomycin.
AID1478529	Ratio of MIC for aminoglycosides-resistant Escherichia coli BL21 harboring pSF815 encode for bifunctional AAC(6')/APH(2\\\\\\\\\\) resistance enzyme to MIC for Escherichia coli BL21	2017	Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11	Covalently linked kanamycin - Ciprofloxacin hybrid antibiotics as a tool to fight bacterial resistance.
AID278564	Antimicrobial activity against 90 mins hydrogen peroxide-stressed Bifidobacterium longum ATCC 15708 after 18 hrs	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID1265798	Antibacterial activity against Escherichia coli MC1061 by microdilution method	2015	Journal of medicinal chemistry, Dec-10, Volume: 58, Issue:23	Synthesis and Bioactivities of Kanamycin B-Derived Cationic Amphiphiles.
AID1562308	Antimycobacterial activity against Mycobacterium smegmatis atR2 assessed as decrease in drug resistance development at 5 ug/disc after 2 to 3 days by paper disc method	2019	European journal of medicinal chemistry, Sep-15, Volume: 178	Synthesis and antimycobacterial activity of imidazo[1,2-b][1,2,4,5]tetrazines.
AID509451	Antibacterial activity against Staphylococcus aureus after 24 hrs by MTT assay	2010	European journal of medicinal chemistry, Sep, Volume: 45, Issue:9	Design and synthesis of potent inhibitors of beta-ketoacyl-acyl carrier protein synthase III (FabH) as potential antibacterial agents.
AID348957	Antibacterial activity against Staphylococcus aureus after 24 hrs by MTT assay	2008	European journal of medicinal chemistry, Jul, Volume: 43, Issue:7	Synthesis and antimicrobial activities of 7-O-modified genistein derivatives.
AID530287	Antimicrobial activity against PR-39-resistant sbmA-deficient Salmonella enterica serovar Typhimurium LT2 DA12088 by Etest	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Mechanism and fitness costs of PR-39 resistance in Salmonella enterica serovar Typhimurium LT2.
AID299671	Antibacterial activity against Staphylococcus aureus by disk diffusion method	2007	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 17, Issue:15	Synthesis and evaluation of amphiphilic cationic quinine-derived for antibacterial activity against methicillin-resistant Staphylococcus aureus.
AID1765578	Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 incubated for 18 hrs by CLSI based broth dilution method	2021	Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15	Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID278558	Antimicrobial activity against 90 mins hydrogen peroxide-stressed Bifidobacterium animalis ATCC 27536 after 18 hrs	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID1490879	Antimycobacterial activity against Mycobacterium smegmatis after 24 hrs by microplate alamar blue assay	2017	Journal of natural products, 05-26, Volume: 80, Issue:5	ent-Abietane and Tigliane Diterpenoids from the Roots of Euphorbia fischeriana and Their Inhibitory Effects against Mycobacterium smegmatis.
AID569260	Antimicrobial activity against Staphylococcus aureus	2011	Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3	Synthesis and evaluation of anti-tubercular activity of new dithiocarbamate sugar derivatives.
AID30395	Minimum inhibitory concentration (MIC) was measured against Acinetobacter baumanni ATCC 19606.	1995	Journal of medicinal chemistry, Nov-10, Volume: 38, Issue:23	Synthesis and antimicrobial and toxicological studies of amino acid and peptide derivatives of kanamycin A and netilmicin.
AID1262360	Antibacterial activity against clinical isolate Gram-negative Pseudomonas syringae after 24 hrs by agar diffusion assay	2015	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 25, Issue:24	PPL catalyzed four-component PASE synthesis of 5-monosubstituted barbiturates: Structure and pharmacological properties.
AID275056	Antibacterial activity against Escherichia coli pTMV19 in presence of mevalonate	2006	Journal of medicinal chemistry, Dec-14, Volume: 49, Issue:25	Isoprenoid biosynthesis as a drug target: bisphosphonate inhibition of Escherichia coli K12 growth and synergistic effects of fosmidomycin.
AID278235	Antimicrobial activity against Salmonella enterica serovar Typhimurium S21-1 tolC::Kan with GyrA S83F mutation	2007	Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2	Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials.
AID1447478	Antibacterial activity against Pseudomonas aeruginosa PAO1 after 18 hrs by microtiter dilution assay	2017	Journal of medicinal chemistry, 05-11, Volume: 60, Issue:9	Amphiphilic Tobramycin-Lysine Conjugates Sensitize Multidrug Resistant Gram-Negative Bacteria to Rifampicin and Minocycline.
AID520874	Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus saprophyticus isolate TSU90 isolated from genitourinary tracts of acute cystitis patient after 24 hrs at 35 degC by agar dilution method	2008	Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6	Methicillin-resistant Staphylococcus saprophyticus isolates carrying staphylococcal cassette chromosome mec have emerged in urogenital tract infections.
AID68538	Minimum inhibitory concentration (MIC) was measured against Enterobacter cloacae.	1995	Journal of medicinal chemistry, Nov-10, Volume: 38, Issue:23	Synthesis and antimicrobial and toxicological studies of amino acid and peptide derivatives of kanamycin A and netilmicin.
AID295898	Antibacterial activity against Escherichia coli ATCC 35218 after 24 hrs by MTT method	2007	Bioorganic & medicinal chemistry, Jun-15, Volume: 15, Issue:12	Synthesis, structure, and structure-activity relationship analysis of enamines as potential antibacterials.
AID540213	Half life in human after iv administration	2008	Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7	Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
AID592501	Antifungal activity against Microbotryum violaceum assessed as zone of inhibition measured as radius at 50 ug by agar diffusion assay	2011	Journal of natural products, Mar-25, Volume: 74, Issue:3	Diversonol and blennolide derivatives from the endophytic fungus Microdiplodia sp.: absolute configuration of diversonol.
AID774300	Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 by microplate Alamar blue assay	2013	Journal of natural products, Oct-25, Volume: 76, Issue:10	Chlorinated coumarins from the polypore mushroom Fomitopsis officinalis and their activity against Mycobacterium tuberculosis.
AID1593375	Inhibition of Pks13 D1644G/N1640K double mutant thioesterase domain in multidrug-resistant Mycobacterium tuberculosis KZN494 assessed as reduction in bacterial growth by microplate alamar blue assay	2019	Journal of medicinal chemistry, 04-11, Volume: 62, Issue:7	Identification of Novel Coumestan Derivatives as Polyketide Synthase 13 Inhibitors against Mycobacterium tuberculosis. Part II.
AID441924	Antibacterial activity against Bacillus anthracis Sterne after 24 hrs by NCCLS method	2009	Journal of medicinal chemistry, Nov-12, Volume: 52, Issue:21	Coordination chemistry based approach to lipophilic inhibitors of 1-deoxy-D-xylulose-5-phosphate reductoisomerase.
AID670726	Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 after 24 hrs by MTT assay	2012	Bioorganic & medicinal chemistry, Jul-15, Volume: 20, Issue:14	Design, synthesis and antimicrobial activities of nitroimidazole derivatives containing 1,3,4-oxadiazole scaffold as FabH inhibitors.
AID326551	Antimicrobial activity against Mycobacterium fortuitum V13 isolate after 3 to 5 days by broth microdilution method	2007	Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5	In Vitro activities of isepamicin, other aminoglycosides, and capreomycin against clinical isolates of rapidly growing mycobacteria in Taiwan.
AID501180	Antimicrobial activity against methicillin sensitive Staphylococcus aureus 310 at 30 ug after 18 hrs by agar diffusion method	2009	Journal of natural products, Oct, Volume: 72, Issue:10	Norselic acids A-E, highly oxidized anti-infective steroids that deter mesograzer predation, from the Antarctic sponge Crella sp.
AID330984	Antimicrobial activity against Staphylococcus aureus 29213	2007	Nature, May-03, Volume: 447, Issue:7140	PTC124 targets genetic disorders caused by nonsense mutations.
AID1638886	Antimicrobial activity against Escherichia coli at 0.5 to 256 ug/ml after 24 hrs by two-fold serial micro dilution method	2019	Journal of natural products, 04-26, Volume: 82, Issue:4	Inducing Secondary Metabolite Production by Co-culture of the Endophytic Fungus Phoma sp. and the Symbiotic Fungus Armillaria sp.
AID1176775	Antimicrobial activity against methicillin-resistant and vancomycin-intermediate Staphylococcus aureus NRS402 after 24 hrs by broth microdilution method	2015	Journal of natural products, Jan-23, Volume: 78, Issue:1	Structure and antimicrobial activity of phloroglucinol derivatives from Achyrocline satureioides.
AID163056	Minimum inhibitory concentration was measured against Proteus rettgeri A 21615	1980	Journal of medicinal chemistry, Jan, Volume: 23, Issue:1	Aminoglycoside antibiotics. 3. Epimino derivatives of neamine, ribostamycin, and kanamycin B.
AID1710559	Antiproliferative activity against human MCF7 cells assessed as reduction in Ki67 expression at 5 uM incubated for 48 hrs by fluorescence microscopy	2018	MedChemComm, Jul-01, Volume: 9, Issue:7	Targeting miRNA by tunable small molecule binders: peptidic aminosugar mediated interference in miR-21 biogenesis reverts epithelial to mesenchymal transition.
AID326538	Antimicrobial activity against Mycobacterium abscessus R39 isolate after 3 to 5 days by broth microdilution method	2007	Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5	In Vitro activities of isepamicin, other aminoglycosides, and capreomycin against clinical isolates of rapidly growing mycobacteria in Taiwan.
AID1413334	Antifungal activity against Candida albicans 94-2181	2018	MedChemComm, Jun-01, Volume: 9, Issue:6	Antifungal amphiphilic kanamycins: new life for an old drug.
AID1624155	Antitubercular activity against multidrug-resistant Mycobacterium tuberculosis isolate 7 after 7 days	2019	European journal of medicinal chemistry, Feb-15, Volume: 164	Synthesis and evaluation of α-aminoacyl amides as antitubercular agents effective on drug resistant tuberculosis.
AID1478522	Antibacterial activity against kanamycin-resistant Escherichia coli AG100A by double microdilution method	2017	Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11	Covalently linked kanamycin - Ciprofloxacin hybrid antibiotics as a tool to fight bacterial resistance.
AID556752	Bactericidal activity against sodA gene-deficient Escherichia coli K-12 3144 after 18 hrs	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	Contribution of oxidative damage to antimicrobial lethality.
AID584325	Antibacterial activity against wild type Escherichia coli BW25113	2010	Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12	Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics.
AID1113099	Antibacterial activity against Bacillus subtilis after 24 hr by microdilution method	2013	Journal of agricultural and food chemistry, Mar-27, Volume: 61, Issue:12	Isolation and characterization of new p-Terphenyls with antifungal, antibacterial, and antioxidant activities from halophilic actinomycete Nocardiopsis gilva YIM 90087.
AID424590	Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH346 (SCV-18) harboring -1 frameshift mutation at nucleotide 238 in rplF gene after 18 to 24 hrs by Etest strip assay	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID1493078	Antibacterial activity against vancomycin-resistant Enterococcus faecalis 12 by dilution susceptibility test	2017	Journal of natural products, 11-22, Volume: 80, Issue:11	Antibacterial 3,6-Disubstituted 4-Hydroxy-5,6-dihydro-2H-pyran-2-ones from Serratia plymuthica MF371-2.
AID534342	Antimicrobial activity against Burkholderia pseudomallei Bp58 harboring deleted bpeR::FRT gene after 24 hrs by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8	The BpeAB-OprB efflux pump of Burkholderia pseudomallei 1026b does not play a role in quorum sensing, virulence factor production, or extrusion of aminoglycosides but is a broad-spectrum drug efflux system.
AID1167354	Antibacterial activity against Escherichia coli D21 tolC deletion mutant after 18 to 24 hrs by two-fold broth microdilution method	2014	Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21	Design, synthesis, and antibacterial properties of dual-ligand inhibitors of acetyl-CoA carboxylase.
AID1182147	Ratio of MIC99 for Mycobacterium smegmatis to ratio of MIC99 for Mycobacterium smegmatis in presence of chlorpromazine	2014	Bioorganic & medicinal chemistry, Aug-15, Volume: 22, Issue:16	Pharmacologically active metabolites, combination screening and target identification-driven drug repositioning in antituberculosis drug discovery.
AID729398	Antimicrobial activity against wild type Escherichia coli K1 after overnight incubation by checkerboard assay	2013	Journal of medicinal chemistry, Mar-14, Volume: 56, Issue:5	Vectorization efforts to increase Gram-negative intracellular drug concentration: a case study on HldE-K inhibitors.
AID1079945	Animal toxicity known. [column 'TOXIC' in source]
AID1467593	Antibacterial activity against Escherichia coli NBRC 102203 after 12 hrs by MTT assay	2017	Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14	New merosesquiterpenes from a Vietnamese marine sponge of Spongia sp. and their biological activities.
AID1287516	Antibacterial activity against Bacillus subtilis NCIM 2079 after 12 hrs	2016	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 26, Issue:7	Synthesis, biological evaluation and molecular docking study of some novel indole and pyridine based 1,3,4-oxadiazole derivatives as potential antitubercular agents.
AID532029	Antimicrobial activity against Escherichia coli TOP10F' transformant harboring beta-lactamase CTX-M-78 by disk diffusion method	2010	Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7	Novel chromosome-encoded CTX-M-78 beta-lactamase from a Kluyvera georgiana clinical isolate as a putative origin of CTX-M-25 subgroup.
AID69506	Minimum inhibitory concentration was measured against Escherichia coli A 20507	1980	Journal of medicinal chemistry, Jan, Volume: 23, Issue:1	Aminoglycoside antibiotics. 3. Epimino derivatives of neamine, ribostamycin, and kanamycin B.
AID740234	Antibacterial activity against Bacillus subtilis ATCC 6538 assessed as growth inhibition after 24 hrs by MTT assay	2013	Bioorganic & medicinal chemistry, Apr-15, Volume: 21, Issue:8	Novel 1,3,4-oxadiazole thioether derivatives targeting thymidylate synthase as dual anticancer/antimicrobial agents.
AID556563	Antimicrobial activity against sodB gene-deficient Escherichia coli K-12 3145 by broth dilution method	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	Contribution of oxidative damage to antimicrobial lethality.
AID1105383	Antibacterial activity against Erwinia chrysanthemi ITCC B-40 assessed as as growth inhibition at 25 ug/disk after 24 hr by disk diffusion method	2013	European journal of medicinal chemistry, Jan, Volume: 59	Microwave synthesis, characterization and bio-efficacy evaluation of novel chalcone based 6-carbethoxy-2-cyclohexen-1-one and 2H-indazol-3-ol derivatives.
AID534340	Antimicrobial activity against Burkholderia pseudomallei Bp50 harboring deleted (amrRAB-oprA)::FRT gene after 24 hrs by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8	The BpeAB-OprB efflux pump of Burkholderia pseudomallei 1026b does not play a role in quorum sensing, virulence factor production, or extrusion of aminoglycosides but is a broad-spectrum drug efflux system.
AID1287417	Ratio of MIC for Mycobacterium bovis BCG overexpressing InhA to MIC for Mycobacterium bovis BCG	2016	European journal of medicinal chemistry, Apr-13, Volume: 112	New direct inhibitors of InhA with antimycobacterial activity based on a tetrahydropyran scaffold.
AID283531	Antibacterial activity against Pseudomonas aeruginosa FE49 with inactivated galU gene by microdilution method	2007	Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3	Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides.
AID1167357	Antibacterial activity against wild type Staphylococcus aureus ATCC 29213 after 18 to 24 hrs by two-fold broth microdilution method	2014	Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21	Design, synthesis, and antibacterial properties of dual-ligand inhibitors of acetyl-CoA carboxylase.
AID563507	Antimicrobial activity against cetylpyridinium chloride-sensitive Serratia marcescens 71 harboring plasmid STV29 expressing hasF gene by broth dilution method	2009	Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12	Mutational upregulation of a resistance-nodulation-cell division-type multidrug efflux pump, SdeAB, upon exposure to a biocide, cetylpyridinium chloride, and antibiotic resistance in Serratia marcescens.
AID278267	Antimicrobial activity against Salmonella enterica serovar Typhimurium CHS18 tolC::Kan with GyrA S38F mutation	2007	Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2	Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials.
AID544028	Antimicrobial activity against Acinetobacter lwoffii isolate C141 harboring sul1 to sul3 genes assessed as antibiotic resistance breakpoint by agar dilution method	2009	Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2	Prevalence of sulfonamide resistance genes in bacterial isolates from manured agricultural soils and pig slurry in the United Kingdom.
AID1167353	Antibacterial activity against Escherichia coli D21 IpxC101 deletion mutant after 18 to 24 hrs by two-fold broth microdilution method	2014	Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21	Design, synthesis, and antibacterial properties of dual-ligand inhibitors of acetyl-CoA carboxylase.
AID1193567	Antibacterial activity against Proteus mirabilis ATCC 14153 at 100 ug after 24 hrs	2015	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 25, Issue:7	Synthesis of 3-azabicyclo[3.2.2]nonanes and their antiprotozoal activities.
AID1455936	Antibacterial activity against Micrococcus luteus after 48 hrs by broth micro-dilution method	2017	Journal of natural products, 02-24, Volume: 80, Issue:2	Nabscessins A and B, Aminocyclitol Derivatives from Nocardia abscessus IFM 10029
AID1585653	Antibacterial activity against methicillin-resistant Staphylococcus epidermidis after overnight incubation by micro broth dilution analysis	2019	European journal of medicinal chemistry, Jan-15, Volume: 162	Discovery of novel arylethenesulfonyl fluorides as potential candidates against methicillin-resistant of Staphylococcus aureus (MRSA) for overcoming multidrug resistance of bacterial infections.
AID278239	Antimicrobial activity against Salmonella enterica serovar Typhimurium S21-2 tolC::Kan with GyrA S83F, ParC S80I mutation	2007	Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2	Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials.
AID278268	Antimicrobial activity against Salmonella enterica serovar Typhimurium CHS38 with GyrA D87G mutation	2007	Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2	Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials.
AID563501	Antimicrobial activity against cetylpyridinium chloride-resistant Serratia marcescens 01 by broth dilution method	2009	Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12	Mutational upregulation of a resistance-nodulation-cell division-type multidrug efflux pump, SdeAB, upon exposure to a biocide, cetylpyridinium chloride, and antibiotic resistance in Serratia marcescens.
AID1616527	Antibacterial activity against Pseudomonas aeruginosa ATCC 15442 assessed as growth inhibition at 0.125 mg/ml by microbroth dilution method relative to control	2019	Journal of natural products, 10-25, Volume: 82, Issue:10	Polyketides from Marine-Derived
AID1905606	Induction of drug resistance in Staphylococcus aureus ATCC 25923 assessed as fold increase in MIC after 5 passages by CLSI protocol based broth microdilution method	2022	Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7	Novel β-Hairpin Antimicrobial Peptides Containing the β-Turn Sequence of -RRRF- Having High Cell Selectivity and Low Incidence of Drug Resistance.
AID278252	Antimicrobial activity against Salmonella enterica serovar Typhimurium CS3 with GyrA S83F, D87N, ParC S80I mutation	2007	Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2	Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials.
AID424826	Antibacterial activity against kanamycin-resistant and fusidic acid-susceptible Staphylococcus aureus AH298 harboring Gly664Val mutation in fusA gene after 18 to 24 hrs by Etest strip assay	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID245396	Minimum inhibitory concentration against Mycobacterium tuberculosis H37Rv pFPCA1 in green fluorescent protein microplate assay	2005	Bioorganic & medicinal chemistry letters, Sep-15, Volume: 15, Issue:18	Identification of heteroarylenamines as a new class of antituberculosis lead molecules.
AID424342	Antibacterial activity against fusidic acid-resistant Staphylococcus aureus AH187 harboring His457Tyr mutation in fusA gene after 18 to 24 hrs by Etest strip assay	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID1890848	Selectivity index, ratio of MIC90 for antimycobacterial activity against Mycobacterium smegmatis mc2 155 harbouring pMyC::PDFMtb overexpression mutant to MIC90 for antimycobacterial activity against wild type Mycobacterium smegmatis mc2 155	2022	Bioorganic & medicinal chemistry letters, 05-15, Volume: 64	Design, synthesis and antibacterial activity against pathogenic mycobacteria of conjugated hydroxamic acids, hydrazides and O-alkyl/O-acyl protected hydroxamic derivatives.
AID207041	Antibacterial activity expressed as MIC value was determined on Staphylococcus aureus A-22210 organism	1986	Journal of medicinal chemistry, May, Volume: 29, Issue:5	Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin.
AID1182142	Antitubercular activity against Mycobacterium smegmatis by checkerboard assay in presence of nor-chlorpromazine	2014	Bioorganic & medicinal chemistry, Aug-15, Volume: 22, Issue:16	Pharmacologically active metabolites, combination screening and target identification-driven drug repositioning in antituberculosis drug discovery.
AID1191413	Antimicrobial activity against Staphylococcus aureus PCM 2602 (ATCC 6538) after 16 to 20 hrs by broth micro-dilution method	2015	Bioorganic & medicinal chemistry letters, Feb-01, Volume: 25, Issue:3	In vitro studies of antimicrobial activity of Gly-His-Lys conjugates as potential and promising candidates for therapeutics in skin and tissue infections.
AID524394	Antibacterial activity against Escherichia coli NKE1355 harboring deletion mutation in acrB protein and plasmid expressing BAD gene in presence of increasing concentration of arabinose	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Effect of NlpE overproduction on multidrug resistance in Escherichia coli.
AID1478525	Antibacterial activity against aminoglycosides-susceptible Bacillus subtilis by double microdilution method	2017	Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11	Covalently linked kanamycin - Ciprofloxacin hybrid antibiotics as a tool to fight bacterial resistance.
AID1226731	Antimicrobial activity against Staphylococcus aureus incubated at 37 degC overnight for 18 hrs	2015	ACS medicinal chemistry letters, Apr-09, Volume: 6, Issue:4	Membrane-Targeting DCAP Analogues with Broad-Spectrum Antibiotic Activity against Pathogenic Bacteria.
AID1585671	Antibacterial activity against methicillin-resistant Staphylococcus epidermidis assessed as zone of inhibition at 30 ug/mL after 24 hrs by agar disc diffusion method	2019	European journal of medicinal chemistry, Jan-15, Volume: 162	Discovery of novel arylethenesulfonyl fluorides as potential candidates against methicillin-resistant of Staphylococcus aureus (MRSA) for overcoming multidrug resistance of bacterial infections.
AID1287400	Antimicrobial activity against Staphylococcus aureus after 24 hrs by serial two-fold microbroth dilution method	2016	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 26, Issue:6	One-pot synthesis and antimicrobial evaluation of novel 3-cyanopyridine derivatives of (-)-β-pinene.
AID1740924	Selectivity ratio of IC50 for inhibition of human Cx43 to IC50 for inhibition of human Cx26	2020	European journal of medicinal chemistry, Oct-01, Volume: 203	Amphiphilic aminoglycosides with increased selectivity for inhibition of connexin 43 (Cx43) hemichannels.
AID1334267	Antibacterial activity against Pseudomonas aeruginosa	2017	Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2	New bithiazolyl hydrazones: Novel synthesis, characterization and antitubercular evaluation.
AID1617945	Antibacterial activity against Salmonella enterica ATCC 10708 after 16 to 48 hrs	2019	Journal of natural products, 12-27, Volume: 82, Issue:12	Structure Determination, Functional Characterization, and Biosynthetic Implications of Nybomycin Metabolites from a Mining Reclamation Site-Associated
AID520868	Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus saprophyticus isolate TSU28 isolated from genitourinary tracts of acute cystitis patient after 24 hrs at 35 degC by agar dilution method	2008	Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6	Methicillin-resistant Staphylococcus saprophyticus isolates carrying staphylococcal cassette chromosome mec have emerged in urogenital tract infections.
AID1629132	Antimicrobial activity against aminoglycoside-resistant Klebsiella pneumoniae ATCC BAA-2470 measured after 24 hrs by double-dilution method	2016	Journal of medicinal chemistry, 09-08, Volume: 59, Issue:17	Effects of 5-O-Ribosylation of Aminoglycosides on Antimicrobial Activity and Selective Perturbation of Bacterial Translation.
AID565419	Antimicrobial activity against Salmonella enterica serotype Virchow isolate AM23818 expressing rmtC rRNA methyltransferase gene by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	Identification of the aminoglycoside resistance determinants armA and rmtC among non-Typhi Salmonella isolates from humans in the United States.
AID584123	Antimicrobial activity against Staphylococcus aureus RN4220 carrying pAFS11-apmA, erm(B), tet(L), dfrK, aadD resistance genes by CLSI M31-A3 method	2011	Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1	Novel apramycin resistance gene apmA in bovine and porcine methicillin-resistant Staphylococcus aureus ST398 isolates.
AID532988	Antibacterial activity against Klebsiella aerogenes NCIM 2281	2010	Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8	N-acetylcysteine-mediated modulation of bacterial antibiotic susceptibility.
AID1105402	Antibacterial activity against Bacillus thuringiensis MTCC 6941 assessed as growth inhibition at 25 ug/disk after 24 hr by disk diffusion method	2013	European journal of medicinal chemistry, Jan, Volume: 59	Microwave synthesis, characterization and bio-efficacy evaluation of novel chalcone based 6-carbethoxy-2-cyclohexen-1-one and 2H-indazol-3-ol derivatives.
AID278525	Antimicrobial activity against Bifidobacterium breve ATCC 15700	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID1079948	Times to onset, minimal and maximal, observed in the indexed observations. [column 'DELAI' in source]
AID1132231	Antibacterial activity against kanamycin and gentamicin-resistant Pseudomonas aeruginosa 3033 assessed as growth inhibition by agar dilution method	1978	Journal of medicinal chemistry, Feb, Volume: 21, Issue:2	Chemical modification of 1,4-diamino-1,4-dideoxy-3-O-(4-deoxy-4-propionamido-alpha-D-glucopyranosyl)-D-glucitol.
AID299665	Antibacterial activity against Bacillus subtilis ATCC 6633 by broth microdilution method	2007	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 17, Issue:15	Synthesis and evaluation of amphiphilic cationic quinine-derived for antibacterial activity against methicillin-resistant Staphylococcus aureus.
AID1299579	Antibacterial activity against Staphylococcus aureus RN4220 ATCC 35556 incubated overnight by microbroth dilution method	2016	Journal of medicinal chemistry, Apr-14, Volume: 59, Issue:7	Antibacterial Diamines Targeting Bacterial Membranes.
AID1293900	Antibacterial activity against Staphylococcus aureus after 18 hrs by broth dilution method	2016	Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9	Novel tetrazoloquinoline-rhodanine conjugates: Highly efficient synthesis and biological evaluation.
AID771508	Antibacterial activity against Staphylococcus aureus RN4220 by dilution technique	2013	European journal of medicinal chemistry, Oct, Volume: 68	Synthesis and biological evaluation of novel ocotillol-type triterpenoid derivatives as antibacterial agents.
AID290150	Antifungal activity against Trichophyton rubrum after 48 hrs by MTT colorimetric method	2007	European journal of medicinal chemistry, Apr, Volume: 42, Issue:4	Synthesis and antimicrobial activities of Schiff bases derived from 5-chloro-salicylaldehyde.
AID1265799	Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 by microdilution method	2015	Journal of medicinal chemistry, Dec-10, Volume: 58, Issue:23	Synthesis and Bioactivities of Kanamycin B-Derived Cationic Amphiphiles.
AID164256	Antibacterial activity expressed as MIC value was determined on Pseudomonas aeruginosa A-21508 organism	1986	Journal of medicinal chemistry, May, Volume: 29, Issue:5	Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin.
AID1738319	Antibacterial activity against Staphylococcus aureus Newman strain assessed as reduction in bacterial growth incubated for 16 to 18 hrs by two fold serial dilution method	2020	European journal of medicinal chemistry, Jul-15, Volume: 198	Capsaicin derivatives with nitrothiophene substituents: Design, synthesis and antibacterial activity against multidrug-resistant S. aureus.
AID1566495	Inhibition of biotinylated pre-let-7d (unknown origin) maturation at 1 mM preincubated for 15 mins followed by Pre-let-7d addition and measured after 5 hrs by cat-ELCCA	2019	ACS medicinal chemistry letters, May-09, Volume: 10, Issue:5	Tetracyclines as Inhibitors of Pre-microRNA Maturation: A Disconnection between RNA Binding and Inhibition.
AID1334266	Antibacterial activity against Escherichia coli	2017	Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2	New bithiazolyl hydrazones: Novel synthesis, characterization and antitubercular evaluation.
AID560599	Antimicrobial activity against Escherichia coli JM109 transformant harboring pSTV28 plasmid expressing aac(6')-Iaf wild type gene by microdilution method	2009	Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6	AAC(6')-Iaf, a novel aminoglycoside 6'-N-acetyltransferase from multidrug-resistant Pseudomonas aeruginosa clinical isolates.
AID492160	Antimicrobial activity against Escherichia coli ATCC 8739 at 100 ug/well after 24 hrs at 37 degC by agar diffusion assay	2010	Journal of natural products, Jul-23, Volume: 73, Issue:7	Cellular localization of clathridimine, an antimicrobial 2-aminoimidazole alkaloid produced by the Mediterranean calcareous sponge Clathrina clathrus.
AID523398	Antimicrobial activity against amikacin-susceptible Nocardia farcinica IFM 10152 harboring 16s rRNA A1408G mutant after 5 days by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6	Homozygous triplicate mutations in three 16S rRNA genes responsible for high-level aminoglycoside resistance in Nocardia farcinica clinical isolates from a Canada-wide bovine mastitis epizootic.
AID1436940	Antibacterial activity against Pseudomonas fluorescens ATCC 13525 after 8 hrs	2017	Bioorganic & medicinal chemistry letters, 02-15, Volume: 27, Issue:4	Quinolidene based monocarbonyl curcumin analogues as promising antimycobacterial agents: Synthesis and molecular docking study.
AID580177	Antimicrobial activity against Bacillus subtilis ATCC 6633 after 24 hrs by MTT assay	2011	Bioorganic & medicinal chemistry, Mar-01, Volume: 19, Issue:5	Synthesis, structure, molecular docking, and structure-activity relationship analysis of enamines: 3-aryl-4-alkylaminofuran-2(5H)-ones as potential antibacterials.
AID145297	Tested for antibacterial activity against Mycobacterium tuberculosis H37Rv streptomycin resistant strain	1985	Journal of medicinal chemistry, Dec, Volume: 28, Issue:12	Synthesis and antibacterial activity of 2,2'-dithiobis(benzamide) derivatives against Mycobacterium species.
AID1436942	Antibacterial activity against Bacillus subtilis ATCC 23857 after 12 hrs	2017	Bioorganic & medicinal chemistry letters, 02-15, Volume: 27, Issue:4	Quinolidene based monocarbonyl curcumin analogues as promising antimycobacterial agents: Synthesis and molecular docking study.
AID278563	Antimicrobial activity against 90 mins hydrogen peroxide-stressed Bifidobacterium longum ATCC 15707 after 18 hrs	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID1905614	Antimicrobial activity against kanamycin-resistant Staphylococcus aureus ATCC 25923	2022	Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7	Novel β-Hairpin Antimicrobial Peptides Containing the β-Turn Sequence of -RRRF- Having High Cell Selectivity and Low Incidence of Drug Resistance.
AID524387	Antibacterial activity against Escherichia coli NKE1365 harboring deletion mutation in acrB and mdtABC protein	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Effect of NlpE overproduction on multidrug resistance in Escherichia coli.
AID424588	Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH348 (SCV-20) harboring TGA stop codon at nucleotide 244 in rplF gene after 18 to 24 hrs by Etest strip assay	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID574590	Antimycobacterial activity against extensively drug-resistant Mycobacterium tuberculosis isolate 761 obtained from pus of patient at 4 ug/ml by Bactec MGIT960 modified proportion method	2010	Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11	Emergence and molecular characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates from the Delhi Region in India.
AID1202742	Antimicrobial activity against Bacillus subtilis assessed as reduction in bacterial growth incubated for 48 hrs by microbroth dilution method	2015	Journal of natural products, Feb-27, Volume: 78, Issue:2	Prenylated benzophenones from Triadenum japonicum.
AID1385094	Inhibition of recombinant human Cx26 expressed in Escherichia coli LB2003 assessed as reduction in cell growth measured after 18 hrs	2018	ACS medicinal chemistry letters, Jul-12, Volume: 9, Issue:7	Inhibition of Connexin Hemichannels by New Amphiphilic Aminoglycosides without Antibiotic Activity.
AID278228	Antimicrobial activity against Salmonella enterica serovar Typhimurium S21	2007	Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2	Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials.
AID278265	Antimicrobial activity against Salmonella enterica serovar Typhimurium CHS18 gyrA+ with GyrA S38F mutation	2007	Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2	Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials.
AID283537	Antibacterial activity against Pseudomonas aeruginosa FE57U with inactivated rplY and galU genes by microdilution method	2007	Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3	Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides.
AID1510724	Antibacterial activity against Staphylococcus aureus	2019	European journal of medicinal chemistry, Oct-01, Volume: 179	Nitroimidazole-containing compounds and their antibacterial and antitubercular activities.
AID740235	Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 assessed as growth inhibition after 24 hrs by MTT assay	2013	Bioorganic & medicinal chemistry, Apr-15, Volume: 21, Issue:8	Novel 1,3,4-oxadiazole thioether derivatives targeting thymidylate synthase as dual anticancer/antimicrobial agents.
AID293135	Antimicrobial activity against Bacillus subtilis	2007	Bioorganic & medicinal chemistry letters, Feb-01, Volume: 17, Issue:3	Design, synthesis, and evaluation of efflux substrate-metal chelator conjugates as potential antimicrobial agents.
AID1478533	Antibacterial activity against Escherichia coli XL1 blue by double microdilution method	2017	Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11	Covalently linked kanamycin - Ciprofloxacin hybrid antibiotics as a tool to fight bacterial resistance.
AID1169514	Antibacterial activity against Pseudomonas aeruginosa after 24 hrs by MTT method	2014	Bioorganic & medicinal chemistry letters, Sep-28	Design, synthesis and biological evaluation of metronidazole-thiazole derivatives as antibacterial inhibitors.
AID1169514	Antibacterial activity against Pseudomonas aeruginosa after 24 hrs by MTT method	2014	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22	Design, synthesis and biological evaluation of metronidazole-thiazole derivatives as antibacterial inhibitors.
AID567091	Drug absorption in human assessed as human intestinal absorption rate	2011	European journal of medicinal chemistry, Jan, Volume: 46, Issue:1	Prediction of drug intestinal absorption by new linear and non-linear QSPR.
AID1695862	Antibacterial activity against Escherichia coli NCIM 2256 incubated for 24 hrs	2019	European journal of medicinal chemistry, Apr-15, Volume: 168	Comprehensive review on the anti-bacterial activity of 1,2,3-triazole hybrids.
AID1226730	Antimicrobial activity against Escherichia coli MG1655 incubated at 37 degC overnight for 18 hrs	2015	ACS medicinal chemistry letters, Apr-09, Volume: 6, Issue:4	Membrane-Targeting DCAP Analogues with Broad-Spectrum Antibiotic Activity against Pathogenic Bacteria.
AID584334	Antibacterial activity against wild type Escherichia coli BW25113 presence of 5 mM of glutathione	2010	Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12	Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics.
AID544288	Antimicrobial activity against Enterococcus faecalis NKH18 harboring pMG2200-like and pMG2201-like plasmids after 24 hrs by agar dilution method	2009	Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2	Isolation of VanB-type Enterococcus faecalis strains from nosocomial infections: first report of the isolation and identification of the pheromone-responsive plasmids pMG2200, Encoding VanB-type vancomycin resistance and a Bac41-type bacteriocin, and pMG2
AID293862	Antibacterial activity against methicillin-resistant Staphylococcus aureus CMAH 0515 after 24 hrs by two fold dilution method	2007	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6	Synthesis of pseudopeptides based L-tryptophan as a potential antimicrobial agent.
AID374113	Antimicrobial activity against azide-resistant Escherichia coli J53 by agar dilution method	2007	Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11	Prevalence and expression of the plasmid-mediated quinolone resistance determinant qnrA1.
AID588122	Ratio of MIC for Streptococcus pyogenes 12RF transconjugant harboring ermB and tetW gene from Streptococcus suis UD to wild type Streptococcus suis UD	2011	Antimicrobial agents and chemotherapy, Feb, Volume: 55, Issue:2	Different genetic elements carrying the tet(W) gene in two human clinical isolates of Streptococcus suis.
AID1629126	Antimicrobial activity against Klebsiella pneumoniae ATCC 13883 measured after 24 hrs by double-dilution method	2016	Journal of medicinal chemistry, 09-08, Volume: 59, Issue:17	Effects of 5-O-Ribosylation of Aminoglycosides on Antimicrobial Activity and Selective Perturbation of Bacterial Translation.
AID1565716	Antifungal activity against Fusarium graminearum B4-5A incubated for 24 to 36 hrs by two fold dilution method	2019	European journal of medicinal chemistry, Nov-15, Volume: 182	Scalable and cost-effective tosylation-mediated synthesis of antifungal and fungal diagnostic 6″-Modified amphiphilic kanamycins.
AID278257	Antimicrobial activity against Salmonella enterica serovar Typhimurium CS9 gyrA+ with GyrA S83F, D87N, ParC S80I mutation	2007	Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2	Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials.
AID299667	Antibacterial activity against Escherichia coli ATCC 25922 by broth microdilution method	2007	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 17, Issue:15	Synthesis and evaluation of amphiphilic cationic quinine-derived for antibacterial activity against methicillin-resistant Staphylococcus aureus.
AID1056536	Antibacterial activity against methicillin-resistant Staphylococcus aureus clinical isolate shhs-A1 by broth microdilution method	2013	Journal of natural products, Dec-27, Volume: 76, Issue:12	Cytotoxic and antibacterial marfuraquinocins from the deep South China Sea-derived Streptomyces niveus SCSIO 3406.
AID278248	Antimicrobial activity against Salmonella enterica serovar Typhimurium CS1 with GyrA S83F, D87N, ParC S80I mutation	2007	Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2	Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials.
AID1169515	Antibacterial activity against Bacillus thuringiensis after 24 hrs by MTT method	2014	Bioorganic & medicinal chemistry letters, Sep-28	Design, synthesis and biological evaluation of metronidazole-thiazole derivatives as antibacterial inhibitors.
AID1169515	Antibacterial activity against Bacillus thuringiensis after 24 hrs by MTT method	2014	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22	Design, synthesis and biological evaluation of metronidazole-thiazole derivatives as antibacterial inhibitors.
AID544029	Antimicrobial activity against Bacillus psychrodurans isolate C328 harboring sul1 to sul3 genes assessed as antibiotic resistance breakpoint by agar dilution method	2009	Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2	Prevalence of sulfonamide resistance genes in bacterial isolates from manured agricultural soils and pig slurry in the United Kingdom.
AID1306203	Bactericidal activity against Staphylococcus aureus ATCC 25923 after 18 hrs by microbroth dilution assay	2016	Bioorganic & medicinal chemistry, 07-15, Volume: 24, Issue:14	The influence of halogen substituents on the biological properties of sulfur-containing flavonoids.
AID556565	Antimicrobial activity against katG gene-deficient Escherichia coli K-12 3157 by broth dilution method	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	Contribution of oxidative damage to antimicrobial lethality.
AID759043	Antibacterial activity against Pseudomonas aeruginosa assessed as survival after 24 hrs by MTT assay	2013	European journal of medicinal chemistry, Jul, Volume: 65	Potentiating 1-(2-hydroxypropyl)-2-styryl-5-nitroimidazole derivatives against antibacterial agents: design, synthesis and biology analysis.
AID1593384	Growth inhibition of Staphylococcus aureus Newman	2019	Journal of medicinal chemistry, 04-11, Volume: 62, Issue:7	Identification of Novel Coumestan Derivatives as Polyketide Synthase 13 Inhibitors against Mycobacterium tuberculosis. Part II.
AID1402051	Antibacterial activity against Acinetobacter baumannii ATCC 17978 after 18 to 20 hrs by spectrophotometry based microdilution method	2018	European journal of medicinal chemistry, Jan-01, Volume: 143	Synthesis and antimicrobial activity of amino acid and peptide derivatives of mycophenolic acid.
AID585016	Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 335913	2011	Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1	Inhibition of bacterial multidrug resistance by celecoxib, a cyclooxygenase-2 inhibitor.
AID560247	Antibacterial activity against Staphylococcus aureus RN4220 by CLSI method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Novel ABC transporter gene, vga(C), located on a multiresistance plasmid from a porcine methicillin-resistant Staphylococcus aureus ST398 strain.
AID521600	Antibacterial activity against Salmonella enterica serovars virchow isolate 101591 infected in mouse J774A.1 cells at 50 ug/ml after 1hr	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	Aminoglycosides affect intracellular Salmonella enterica serovars typhimurium and virchow.
AID278567	Antimicrobial activity against 90 mins hydrogen peroxide-stressed Bifidobacterium thermophilum ATCC 25866 after 18 hrs	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID563508	Antimicrobial activity against cetylpyridinium chloride-sensitive Serratia marcescens 79 harboring plasmid STV29 by broth dilution method	2009	Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12	Mutational upregulation of a resistance-nodulation-cell division-type multidrug efflux pump, SdeAB, upon exposure to a biocide, cetylpyridinium chloride, and antibiotic resistance in Serratia marcescens.
AID278264	Antimicrobial activity against Salmonella enterica serovar Typhimurium CHS18 with GyrA S38F mutation	2007	Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2	Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials.
AID1303893	Antibacterial activity against multidrug resistant Klebsiella pneumoniae subsp. pneumoniae NCTC 9633 (ATCC 13883) assessed as reduction in bacterial growth incubated for 6 to 8 hrs	2016	Bioorganic & medicinal chemistry letters, 07-01, Volume: 26, Issue:13	GroEL/ES inhibitors as potential antibiotics.
AID374111	Antimicrobial activity against azide-resistant aac(6')-Ib-cr deficient Escherichia coli J53 qnrA1 bearing pHS5 transconjugant from Enterobacter cloacae 641 by agar dilution method	2007	Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11	Prevalence and expression of the plasmid-mediated quinolone resistance determinant qnrA1.
AID424575	Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH364 (SCV-36) harboring Asp434Asn mutation in fusA gene after 18 to 24 hrs by Etest strip assay	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID333430	Antitubercular activity against Mycobacterium tuberculosis H37Ra ATCC 25177 after 4 days by microtiter plate alamar blue technique	2004	Journal of natural products, Oct, Volume: 67, Issue:10	Antitubercular sesterterpenes from the Thai sponge Brachiaster sp.
AID373986	Antimicrobial activity against azide-resistant aac(6')-Ib-cr expressing Escherichia coli J53 qnrA1 bearing pHS3 transconjugant from Citrobacter freundii 64 by agar dilution method	2007	Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11	Prevalence and expression of the plasmid-mediated quinolone resistance determinant qnrA1.
AID1359447	Antibacterial activity against Staphylococcus aureus NCIM 2010 after 12 hrs by serial dilution method	2018	European journal of medicinal chemistry, May-25, Volume: 152	Antibacterial and anti-TB tat-peptidomimetics with improved efficacy and half-life.
AID1629129	Antimicrobial activity against Acinetobacter baumannii ATCC 19606 measured after 24 hrs by double-dilution method	2016	Journal of medicinal chemistry, 09-08, Volume: 59, Issue:17	Effects of 5-O-Ribosylation of Aminoglycosides on Antimicrobial Activity and Selective Perturbation of Bacterial Translation.
AID1473739	Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and GSH measured after 20 mins by membrane vesicle transport assay	2013	Toxicological sciences : an official journal of the Society of Toxicology, Nov, Volume: 136, Issue:1	A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
AID1869566	Bactericidal activity against Enterococcus faecium DSM 20477 assessed as reduction in colony count and measured after 3 days by agar diffusion assay	2022	Journal of natural products, 06-24, Volume: 85, Issue:6	Triculamin: An Unusual Lasso Peptide with Potent Antimycobacterial Activity.
AID1491154	Antibacterial activity against Staphylococcus aureus ATCC 29213 by CLSI method	2017	Journal of natural products, 05-26, Volume: 80, Issue:5	Antimicrobial Spirotetronate Metabolites from Marine-Derived Micromonospora harpali SCSIO GJ089.
AID580178	Antimicrobial activity against Staphylococcus aureus ATCC 25923 after 24 hrs by MTT assay	2011	Bioorganic & medicinal chemistry, Mar-01, Volume: 19, Issue:5	Synthesis, structure, molecular docking, and structure-activity relationship analysis of enamines: 3-aryl-4-alkylaminofuran-2(5H)-ones as potential antibacterials.
AID1113100	Antibacterial activity against Staphylococcus aureus after 24 hr by microdilution method	2013	Journal of agricultural and food chemistry, Mar-27, Volume: 61, Issue:12	Isolation and characterization of new p-Terphenyls with antifungal, antibacterial, and antioxidant activities from halophilic actinomycete Nocardiopsis gilva YIM 90087.
AID515080	Antimycobacterial activity against Mycobacterium tuberculosis H37Ra after 24 hrs by microtiter alamar blue assay	2010	European journal of medicinal chemistry, Oct, Volume: 45, Issue:10	Isoxazole analogs of curcuminoids with highly potent multidrug-resistant antimycobacterial activity.
AID1710553	Displacement of F-neo from premature miRNA21 (unknown origin) by fluorescence assay	2018	MedChemComm, Jul-01, Volume: 9, Issue:7	Targeting miRNA by tunable small molecule binders: peptidic aminosugar mediated interference in miR-21 biogenesis reverts epithelial to mesenchymal transition.
AID325447	Antibacterial activity against Staphylococcus aureus N315 after 14 to 16 hrs by broth dilution method	2007	Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6	Polyamine effects on antibiotic susceptibility in bacteria.
AID275054	Antibacterial activity against Escherichia coli W3110	2006	Journal of medicinal chemistry, Dec-14, Volume: 49, Issue:25	Isoprenoid biosynthesis as a drug target: bisphosphonate inhibition of Escherichia coli K12 growth and synergistic effects of fosmidomycin.
AID529456	Antimicrobial activity against Klebsiella pneumoniae containing PFGE clone A expressing beta-lactamase Oxa-48, TEM-1, SHV-12 and Oxa-9 by Etest	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Spread of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in Istanbul, Turkey.
AID50539	Minimum inhibitory concentration (MIC) was measured against Citrobacter freundii.	1995	Journal of medicinal chemistry, Nov-10, Volume: 38, Issue:23	Synthesis and antimicrobial and toxicological studies of amino acid and peptide derivatives of kanamycin A and netilmicin.
AID556757	Bactericidal activity against katG,katE gene-deficient Escherichia coli K-12 3201 after 18 hrs	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	Contribution of oxidative damage to antimicrobial lethality.
AID586086	Antimicrobial activity against verocytotoxin-producing Escherichia coli isolate O157 obtained from animals and food assessed as percentage of resistant isolates by disk diffusion method	2010	Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11	Antimicrobial resistance testing of verocytotoxin-producing Escherichia coli and first description of TEM-52 extended-spectrum β-lactamase in serogroup O26.
AID424573	Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH366 (SCV-38) harboring Pro114His mutation in fusA gene after 18 to 24 hrs by Etest strip assay	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID68017	Antibacterial activity expressed as MIC value was determined on Enterobacter cloacae A-21136 organism	1986	Journal of medicinal chemistry, May, Volume: 29, Issue:5	Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin.
AID1271376	Antimicrobial activity against Gram-positive Bacillus anthracis str. Sterne after 16 to 24 hrs by micro-dilution method	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Synthesis and Biological Activity of Mono- and Di-N-acylated Aminoglycosides.
AID1882862	Antibacterial activity against Escherichia coli K12 expressing modified luxABCDE genes assessed as reduction in bacterial growth by measuring reduction in bioluminescence at 40 uM incubated for 16 hrs by microplate reader analysis	2022	European journal of medicinal chemistry, Jul-05, Volume: 237	The role of the maleimide ring system on the structure-activity relationship of showdomycin.
AID445210	Antituberculosis activity against Mycobacterium tuberculosis H37Rv by broth dilution method	2009	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 19, Issue:22	Synthesis of new sugar derivatives and evaluation of their antibacterial activities against Mycobacterium tuberculosis.
AID1474167	Liver toxicity in human assessed as induction of drug-induced liver injury by measuring verified drug-induced liver injury concern status	2016	Drug discovery today, Apr, Volume: 21, Issue:4	DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
AID537733	Binding affinity to Candida albicans CaCdr1p expressed in yeast AD1-8u	2010	European journal of medicinal chemistry, Nov, Volume: 45, Issue:11	Analysis of physico-chemical properties of substrates of ABC and MFS multidrug transporters of pathogenic Candida albicans.
AID588213	Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in non-rodents	2010	Chemical research in toxicology, Jan, Volume: 23, Issue:1	Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
AID425073	Antimicrobial activity against Escherichia coli DH10B expressing pCR2.1 in presence of IPTG	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Complex class 1 integrons with diverse variable regions, including aac(6')-Ib-cr, and a novel allele, qnrB10, associated with ISCR1 in clinical enterobacterial isolates from Argentina.
AID69748	Antibacterial activity expressed as MIC value was determined on Escherichia coli A-20665 organism	1986	Journal of medicinal chemistry, May, Volume: 29, Issue:5	Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin.
AID1730999	Antibacterial activity against Bacillus subtilis168 assessed as inhibition of bacterial growth measured after 18 hrs by two fold serial dilution method	2021	European journal of medicinal chemistry, Mar-05, Volume: 213	Design and synthesis of mycobacterial pks13 inhibitors: Conformationally rigid tetracyclic molecules.
AID1079942	Steatosis, proven histopathologically. Value is number of references indexed. [column 'STEAT' in source]
AID1585464	Antibacterial activity against linezolid-resistant Staphylococcus aureus NRS-271 measured after 16 hrs	2019	European journal of medicinal chemistry, Jan-15, Volume: 162	Design, synthesis and evaluation of hybrid of tetrahydrocarbazole with 2,4-diaminopyrimidine scaffold as antibacterial agents.
AID283558	Antibacterial activity against Escherichia coli AG102 with marR1 mutation after 24 hrs	2007	Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3	Substrate competition studies using whole-cell accumulation assays with the major tripartite multidrug efflux pumps of Escherichia coli.
AID544285	Antimicrobial activity against Enterococcus faecalis NKH15 harboring pMG2200-like and pMG2201-like plasmids after 24 hrs by agar dilution method	2009	Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2	Isolation of VanB-type Enterococcus faecalis strains from nosocomial infections: first report of the isolation and identification of the pheromone-responsive plasmids pMG2200, Encoding VanB-type vancomycin resistance and a Bac41-type bacteriocin, and pMG2
AID1263041	Antibacterial activity against Burkholderia thailandensis E264 at 0.5 mM after 24 to 48 hrs by Kirby-Bauer disc diffusion susceptibility test	2015	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 25, Issue:24	Synthesis and biological evaluation of pyrazolopyrimidines as potential antibacterial agents.
AID1710567	Antibacterial activity against Staphylococcus aureus ATCC 25923 assessed as reduction in bacterial growth at 64 uM incubated for 15 to 20 hrs by broth microdilution method relative to control	2018	MedChemComm, Jul-01, Volume: 9, Issue:7	Targeting miRNA by tunable small molecule binders: peptidic aminosugar mediated interference in miR-21 biogenesis reverts epithelial to mesenchymal transition.
AID404897	Antibacterial activity against high-level gentamicin resistant Streptococcus pasteurianus SB30 isolate carrying transposon-borne resistance gene [aac(6')Ie-aph(2'')Ia] by agar dilution method	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	High-level gentamicin resistance mediated by a Tn4001-like transposon in seven nonclonal hospital isolates of Streptococcus pasteurianus.
AID1265796	Antibacterial activity against Acinetobacter baumannii ATCC 19606 by microdilution method	2015	Journal of medicinal chemistry, Dec-10, Volume: 58, Issue:23	Synthesis and Bioactivities of Kanamycin B-Derived Cationic Amphiphiles.
AID486971	Antibacterial activity against Klebsiella pneumoniae ATCC 27736 after 24 hrs by micro broth dilution method	2010	European journal of medicinal chemistry, Jun, Volume: 45, Issue:6	'On water' assisted synthesis and biological evaluation of nitrogen and sulfur containing hetero-1,4-naphthoquinones as potent antifungal and antibacterial agents.
AID1287977	Antibacterial activity against Escherichia coli after 18 hrs by broth dilution method	2016	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 26, Issue:7	Facile synthesis of 1,3-thiazolidin-4-ones as antitubercular agents.
AID424569	Antibacterial activity against stationary-phase rifampin-resistant Staphylococcus aureus 8325-4 culture assessed as number of viable colonies at 8 ug/ ml after 48 hrs	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID1905566	Antimicrobial activity against Escherichia coli ATCC 25922 assessed as reduction of bacterial growth incubated for 18 hrs by CLSI protocol based broth microdilution method	2022	Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7	Novel β-Hairpin Antimicrobial Peptides Containing the β-Turn Sequence of -RRRF- Having High Cell Selectivity and Low Incidence of Drug Resistance.
AID244911	In-vitro minimum inhibitory concentration against the growth of Pseudomonas aeruginosa	2005	Bioorganic & medicinal chemistry letters, Jul-01, Volume: 15, Issue:13	Synthesis of (1,4)-naphthoquinono-[3,2-c]-1H-pyrazoles and their (1,4)-naphthohydroquinone derivatives as antifungal, antibacterial, and anticancer agents.
AID1426254	Antibacterial activity against Klebsiella pneumoniae ATCC 13883	2017	European journal of medicinal chemistry, Jan-27, Volume: 126	Synthesis and bioactivity investigation of quinone-based dimeric cationic triazolium amphiphiles selective against resistant fungal and bacterial pathogens.
AID1182151	Ratio of MIC99 for Mycobacterium smegmatis to ratio of MIC99 for Mycobacterium smegmatis in presence of 7-hydroxy chlorpromazine	2014	Bioorganic & medicinal chemistry, Aug-15, Volume: 22, Issue:16	Pharmacologically active metabolites, combination screening and target identification-driven drug repositioning in antituberculosis drug discovery.
AID387745	Displacement of thiazole orange from RNA A by fluorescent intercalator displacement assay	2008	Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19	Screening helix-threading peptides for RNA binding using a thiazole orange displacement assay.
AID283545	Antibacterial activity against Pseudomonas aeruginosa FE57GUZ with inactivated rplY, nuoG, galU and mexZ genes by microdilution method	2007	Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3	Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides.
AID556758	Bactericidal activity against katE gene-deficient Escherichia coli K-12 3202 after 18 hrs	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	Contribution of oxidative damage to antimicrobial lethality.
AID1491152	Antibacterial activity against Bacillus thuringiensis BT01 by CLSI method	2017	Journal of natural products, 05-26, Volume: 80, Issue:5	Antimicrobial Spirotetronate Metabolites from Marine-Derived Micromonospora harpali SCSIO GJ089.
AID424607	Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH390 (SCV-62) harboring +1 frameshift mutation at nucleotide 84 in rplF gene after 18 to 24 hrs by Etest strip assay	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID293871	Antibacterial activity against Enterobacter aerogenes CMCC(B) 45103 after 24 hrs by two fold dilution method	2007	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6	Synthesis of pseudopeptides based L-tryptophan as a potential antimicrobial agent.
AID69754	Antibacterial activity expressed as MIC value was determined on Escherichia coli A-21218 organism	1986	Journal of medicinal chemistry, May, Volume: 29, Issue:5	Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin.
AID1293899	Antibacterial activity against Pseudomonas fluorescens after 18 hrs by broth dilution method	2016	Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9	Novel tetrazoloquinoline-rhodanine conjugates: Highly efficient synthesis and biological evaluation.
AID604259	Antibacterial activity against Staphylococcus aureus ATCC 25923 after 24 hrs by MTT colorimetric method	2011	Bioorganic & medicinal chemistry, Jul-01, Volume: 19, Issue:13	4-alkoxy-3-arylfuran-2(5H)-ones as inhibitors of tyrosyl-tRNA synthetase: synthesis, molecular docking and antibacterial evaluation.
AID1478521	Antibacterial activity against kanamycin-resistant Escherichia coli AG100B by double microdilution method	2017	Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11	Covalently linked kanamycin - Ciprofloxacin hybrid antibiotics as a tool to fight bacterial resistance.
AID1132238	Antibacterial activity against drug-sensitive Erwinia 1159 assessed as growth inhibition by agar dilution method	1978	Journal of medicinal chemistry, Feb, Volume: 21, Issue:2	Chemical modification of 1,4-diamino-1,4-dideoxy-3-O-(4-deoxy-4-propionamido-alpha-D-glucopyranosyl)-D-glucitol.
AID278244	Antimicrobial activity against Salmonella enterica serovar Typhimurium S21-4 with GyrA S83F, ParC S80I mutation	2007	Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2	Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials.
AID420210	Antimicrobial activity against Mycobacterium smegmatis UFPEDA 71 at 30 ug/disk after 24 hrs by disk diffusion method	2009	European journal of medicinal chemistry, May, Volume: 44, Issue:5	Synthesis, antimicrobial and cytotoxic activities of some 5-arylidene-4-thioxo-thiazolidine-2-ones.
AID1765574	Antibacterial activity against Bacillus subtilis ATCC 23857 incubated for 18 hrs by CLSI based broth dilution method	2021	Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15	Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1585654	Antibacterial activity against methicillin-resistant Staphylococcus haemolyticus after overnight incubation by micro broth dilution analysis	2019	European journal of medicinal chemistry, Jan-15, Volume: 162	Discovery of novel arylethenesulfonyl fluorides as potential candidates against methicillin-resistant of Staphylococcus aureus (MRSA) for overcoming multidrug resistance of bacterial infections.
AID424602	Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH351 (SCV-23) harboring -4 frameshift mutation at nucleotide 45-48 in rplF gene after 18 to 24 hrs by Etest strip assay	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID1250524	Antibacterial activity against Escherichia coli ATCC 35218 after 24 hr by MTT assay	2015	European journal of medicinal chemistry, Sep-18, Volume: 102	Synthesis and evaluation of new tyrosyl-tRNA synthetase inhibitors as antibacterial agents based on a N2-(arylacetyl)glycinanilide scaffold.
AID532983	Antibacterial activity against Escherichia coli W3110	2010	Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8	N-acetylcysteine-mediated modulation of bacterial antibiotic susceptibility.
AID1194691	Antibacterial activity against Staphylococcus aureus ATCC 25923 assessed as inhibition of microbial growth at 0.064 ug/ml to 125 ug/ml incubated at 37 degC for 20 hrs	2015	Bioorganic & medicinal chemistry letters, May-01, Volume: 25, Issue:9	Three new fusidic acid derivatives and their antibacterial activity.
AID145296	Tested for antibacterial activity against Mycobacterium tuberculosis H37Rv kanamycin resistant strain	1985	Journal of medicinal chemistry, Dec, Volume: 28, Issue:12	Synthesis and antibacterial activity of 2,2'-dithiobis(benzamide) derivatives against Mycobacterium species.
AID424345	Antibacterial activity against fusidic acid-resistant Staphylococcus aureus AH188 harboring Gly664Ser mutation in fusA gene after 18 to 24 hrs by Etest strip assay	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID1869571	Antibacterial activity against Acinetobacter baumannii DSM 300007 assessed as reduction in bacterial growth measured after 3 days by broth microdilution method	2022	Journal of natural products, 06-24, Volume: 85, Issue:6	Triculamin: An Unusual Lasso Peptide with Potent Antimycobacterial Activity.
AID556589	Bactericidal activity against Escherichia coli K-12 BW25113 after 18 hrs	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	Contribution of oxidative damage to antimicrobial lethality.
AID1176779	Antimicrobial activity against Candida albicans ATCC 1023 after 24 hrs by broth microdilution method	2015	Journal of natural products, Jan-23, Volume: 78, Issue:1	Structure and antimicrobial activity of phloroglucinol derivatives from Achyrocline satureioides.
AID1426249	Antibacterial activity against Staphylococcus aureus ATCC 25923	2017	European journal of medicinal chemistry, Jan-27, Volume: 126	Synthesis and bioactivity investigation of quinone-based dimeric cationic triazolium amphiphiles selective against resistant fungal and bacterial pathogens.
AID69751	Antibacterial activity expressed as MIC value was determined on Escherichia coli A-20732 organism	1986	Journal of medicinal chemistry, May, Volume: 29, Issue:5	Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin.
AID326535	Antimicrobial activity against Mycobacterium fortuitum after 3 to 5 days by broth microdilution method	2007	Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5	In Vitro activities of isepamicin, other aminoglycosides, and capreomycin against clinical isolates of rapidly growing mycobacteria in Taiwan.
AID1887296	Antibacterial activity against Escherichia coli ATCC 25922 assessed as inhibition of bacterial growth incubated for 24 hrs by optical density based analysis	2022	Journal of natural products, 09-23, Volume: 85, Issue:9	Total Syntheses and Antibacterial Evaluations of Neocyclomorusin and Related Flavones.
AID1359448	Antibacterial activity against Staphylococcus epidermidis NCIM 5270 after 12 hrs by serial dilution method	2018	European journal of medicinal chemistry, May-25, Volume: 152	Antibacterial and anti-TB tat-peptidomimetics with improved efficacy and half-life.
AID697853	Inhibition of horse BChE at 2 mg/ml by Ellman's method	2012	Bioorganic & medicinal chemistry, Nov-15, Volume: 20, Issue:22	Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
AID1738321	Antibacterial activity against multidrug-resistant Staphylococcus aureus NRS70 assessed as reduction in bacterial growth incubated for 16 to 18 hrs by two fold serial dilution method	2020	European journal of medicinal chemistry, Jul-15, Volume: 198	Capsaicin derivatives with nitrothiophene substituents: Design, synthesis and antibacterial activity against multidrug-resistant S. aureus.
AID369075	Antimicrobial activity against Staphylococcus aureus ATCC 6538 after 24 hrs by MTT assay	2009	Bioorganic & medicinal chemistry, Feb-01, Volume: 17, Issue:3	Synthesis, structure and antibacterial activity of new 2-(1-(2-(substituted-phenyl)-5-methyloxazol-4-yl)-3-(2-substitued-phenyl)-4,5-dihydro-1H-pyrazol-5-yl)-7-substitued-1,2,3,4-tetrahydroisoquinoline derivatives.
AID1413324	Antifungal activity against Cryptococcus neoformans H99	2018	MedChemComm, Jun-01, Volume: 9, Issue:6	Antifungal amphiphilic kanamycins: new life for an old drug.
AID1868100	Antibacterial activity against Bacillus subtilis ATCC 6633 assessed as inhibition of visible bacterial growth incubated for 18 hrs by CLSI protocol based assay	2022	Journal of natural products, 05-27, Volume: 85, Issue:5	Enceleamycins A-C, Furo-Naphthoquinones from
AID1347678	Growth inhibition of wild-type Yersinia pseudotuberculosis at 50 ug/ml measured at 1 hr interval for 15 hrs	2017	Journal of natural products, 12-22, Volume: 80, Issue:12	Investigation of the Physical and Bioactive Properties of Bromo- and Iodo-Containing Sponge-Derived Compounds Possessing an Oxyphenylethanamine Core.
AID765043	Antibacterial activity against Escherichia coli ATCC 35218 by MTT assay	2013	Bioorganic & medicinal chemistry, Sep-01, Volume: 21, Issue:17	3-Aryl-4-acyloxyethoxyfuran-2(5H)-ones as inhibitors of tyrosyl-tRNA synthetase: synthesis, molecular docking and antibacterial evaluation.
AID490132	Antibacterial activity against Escherichia coli ATCC 35218 after 24 hrs by MTT assay	2010	European journal of medicinal chemistry, Jul, Volume: 45, Issue:7	Synthesis of some N-alkyl substituted urea derivatives as antibacterial and antifungal agents.
AID1079931	Moderate liver toxicity, defined via clinical-chemistry results: ALT or AST serum activity 6 times the normal upper limit (N) or alkaline phosphatase serum activity of 1.7 N. Value is number of references indexed. [column 'BIOL' in source]
AID326542	Antimicrobial activity against Mycobacterium abscessus NTU446 isolate after 3 to 5 days by broth microdilution method	2007	Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5	In Vitro activities of isepamicin, other aminoglycosides, and capreomycin against clinical isolates of rapidly growing mycobacteria in Taiwan.
AID1055363	Antibacterial activity against Escherichia coli after 18 hrs by turbidity assay	2013	Journal of natural products, Nov-22, Volume: 76, Issue:11	Stereochemical assignment of the fungal metabolites pestalotiopsones D and E through enantiopure synthesis.
AID295900	Antibacterial activity against Staphylococcus aureus ATCC 6538 after 24 hrs by MTT method	2007	Bioorganic & medicinal chemistry, Jun-15, Volume: 15, Issue:12	Synthesis, structure, and structure-activity relationship analysis of enamines as potential antibacterials.
AID1287513	Antibacterial activity against Escherichia coli NCIM 2688 after 8 hrs	2016	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 26, Issue:7	Synthesis, biological evaluation and molecular docking study of some novel indole and pyridine based 1,3,4-oxadiazole derivatives as potential antitubercular agents.
AID1326387	Antibacterial activity against Bacillus subtilis P10C derived after 10 passage in presence of JBIR-100 after 16 to 18 hrs by microbroth dilution assay	2016	Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24	Biological characterization of the hygrobafilomycin antibiotic JBIR-100 and bioinformatic insights into the hygrolide family of natural products.
AID1337848	Antifungal activity against Cryptococcus neoformans NCIM 576 by standard agar method	2017	European journal of medicinal chemistry, Jan-05, Volume: 125	Quinolidene-rhodanine conjugates: Facile synthesis and biological evaluation.
AID1334268	Antibacterial activity against Staphylococcus aureus	2017	Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2	New bithiazolyl hydrazones: Novel synthesis, characterization and antitubercular evaluation.
AID1413339	Antifungal activity against Aspergillus flavus	2018	MedChemComm, Jun-01, Volume: 9, Issue:6	Antifungal amphiphilic kanamycins: new life for an old drug.
AID1862201	Antimycobacterial activity against clinical isolate drug susceptible Mycobacterium tuberculosis H37Rv assessed as bacterial growth inhibition	2022	Bioorganic & medicinal chemistry letters, 09-15, Volume: 72	Discovery and preclinical evaluations of JBD0131, a novel nitrodihydro-imidazooxazole anti-tuberculosis agent.
AID69129	Inhibition of cell free transcription/translation by Escherichia coli s30 bacterial extract.	2002	Journal of medicinal chemistry, Aug-01, Volume: 45, Issue:16	New inhibitors of bacterial protein synthesis from a combinatorial library of macrocycles.
AID1287979	Antibacterial activity against Staphylococcus aureus after 18 hrs by broth dilution method	2016	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 26, Issue:7	Facile synthesis of 1,3-thiazolidin-4-ones as antitubercular agents.
AID69750	Antibacterial activity expressed as MIC value was determined on Escherichia coli A-20697 organism	1986	Journal of medicinal chemistry, May, Volume: 29, Issue:5	Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin.
AID1337785	Antifungal activity against Fusarium oxysporum NCIM 1332 by standard agar method	2017	European journal of medicinal chemistry, Jan-05, Volume: 125	Quinolidene-rhodanine conjugates: Facile synthesis and biological evaluation.
AID540211	Fraction unbound in human after iv administration	2008	Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7	Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
AID1710562	Antibacterial activity against Escherichia coli ATCC 25922 assessed as reduction in bacterial growth incubated for 15 to 20 hrs by broth microdilution method	2018	MedChemComm, Jul-01, Volume: 9, Issue:7	Targeting miRNA by tunable small molecule binders: peptidic aminosugar mediated interference in miR-21 biogenesis reverts epithelial to mesenchymal transition.
AID283544	Antibacterial activity against Pseudomonas aeruginosa FE57GZ with inactivated rplY, nuoG and mexZ genes by microdilution method	2007	Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3	Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides.
AID1287978	Antibacterial activity against Pseudomonas after 18 hrs by broth dilution method	2016	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 26, Issue:7	Facile synthesis of 1,3-thiazolidin-4-ones as antitubercular agents.
AID257552	Antibacterial activity against Escherichia coli	2005	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 15, Issue:23	Synthesis and biological evaluation of novel (L)-alpha-amino acid methyl ester, heteroalkyl, and aryl substituted 1,4-naphthoquinone derivatives as antifungal and antibacterial agents.
AID1478538	Inhibition of protein translation in Escherichia coli S30 cell extract using circular DNA with pBESTluc after 60 mins	2017	Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11	Covalently linked kanamycin - Ciprofloxacin hybrid antibiotics as a tool to fight bacterial resistance.
AID425023	Antimicrobial activity against Mycobacterium tuberculosis H37Ra by microplate alamar blue assay	2009	Journal of natural products, May-22, Volume: 72, Issue:5	Biomimetic transformation and biological activities of Globiferin, a terpenoid benzoquinone from Cordia globifera.
AID278550	Antimicrobial activity against 90 mins oxgall-stressed Bifidobacterium breve R0070 after 18 hrs	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID521575	Reduction in light emission by Salmonella enterica serovars virchow isolate 101591 infected in mouse J774A.1 cells after 5 mins	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	Aminoglycosides affect intracellular Salmonella enterica serovars typhimurium and virchow.
AID278546	Antimicrobial activity against 90 mins oxgall-stressed Bifidobacterium bifidum R0071 after 18 hrs	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID1695864	Antibacterial activity against Flavobacterium devorans ATCC 10829 incubated for 24 hrs	2019	European journal of medicinal chemistry, Apr-15, Volume: 168	Comprehensive review on the anti-bacterial activity of 1,2,3-triazole hybrids.
AID521583	Antibacterial activity against Salmonella enterica serovars Typhimurium ATCC 14028 infected in mouse J774A.1 macrophage assessed as log reduction in viable counts at 150 ug/ml after 1hr	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	Aminoglycosides affect intracellular Salmonella enterica serovars typhimurium and virchow.
AID1565707	Antifungal activity against azole-resistant Candida albicans 64124 incubated for 24 to 36 hrs by two fold dilution method	2019	European journal of medicinal chemistry, Nov-15, Volume: 182	Scalable and cost-effective tosylation-mediated synthesis of antifungal and fungal diagnostic 6″-Modified amphiphilic kanamycins.
AID1617679	Antibacterial activity against Staphylococcus aureus 745524 by CLSI based two-fold serial dilution method
AID524388	Antibacterial activity against Escherichia coli NKE1366 harboring deletion mutation in acrB and vector expressing mdtABC gene	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Effect of NlpE overproduction on multidrug resistance in Escherichia coli.
AID278544	Antimicrobial activity against 60 min 1 M HCl-stressed Bifidobacterium thermophilum ATCC 25866 after 18 hrs	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID1765576	Antibacterial activity against Staphylococcus epidermidis ATCC 12228 incubated for 18 hrs by CLSI based broth dilution method	2021	Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15	Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1182131	Antitubercular activity against Mycobacterium smegmatis by checkerboard assay	2014	Bioorganic & medicinal chemistry, Aug-15, Volume: 22, Issue:16	Pharmacologically active metabolites, combination screening and target identification-driven drug repositioning in antituberculosis drug discovery.
AID1164941	Antimicrobial activity against Enterococcus faecalis ATCC 33186 by microbroth dilution method	2014	Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20	Synthesis, structure-activity relationship studies, and antibacterial evaluation of 4-chromanones and chalcones, as well as olympicin A and derivatives.
AID445287	Antibacterial activity against Mycobacterium avium SmO by broth dilution method	2009	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 19, Issue:22	Synthesis of new sugar derivatives and evaluation of their antibacterial activities against Mycobacterium tuberculosis.
AID1263040	Antibacterial activity against Burkholderia thailandensis E264 at 1 mM after 24 to 48 hrs by Kirby-Bauer disc diffusion susceptibility test	2015	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 25, Issue:24	Synthesis and biological evaluation of pyrazolopyrimidines as potential antibacterial agents.
AID1079933	Acute liver toxicity defined via clinical observations and clear clinical-chemistry results: serum ALT or AST activity > 6 N or serum alkaline phosphatases activity > 1.7 N. This category includes cytolytic, choleostatic and mixed liver toxicity. Value is
AID1426253	Antibacterial activity against Pseudomonas aeruginosa ATCC 27853	2017	European journal of medicinal chemistry, Jan-27, Volume: 126	Synthesis and bioactivity investigation of quinone-based dimeric cationic triazolium amphiphiles selective against resistant fungal and bacterial pathogens.
AID381179	Antibacterial activity against penicillin-resistant Staphylococcus aureus after 24 to 72 hrs by disk diffusion method	1999	Journal of natural products, Sep, Volume: 62, Issue:9	Antimicrobial and antitumor activities of mycosporulone.
AID405455	Antibacterial activity against Escherichia coli 1540 isolate by disk diffusion method	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	Transferable resistance to aminoglycosides by methylation of G1405 in 16S rRNA and to hydrophilic fluoroquinolones by QepA-mediated efflux in Escherichia coli.
AID1413327	Antifungal activity against Candida lusitaniae 95-767	2018	MedChemComm, Jun-01, Volume: 9, Issue:6	Antifungal amphiphilic kanamycins: new life for an old drug.
AID326533	Antimicrobial activity against Mycobacterium abscessus after 3 to 5 days by broth microdilution method	2007	Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5	In Vitro activities of isepamicin, other aminoglycosides, and capreomycin against clinical isolates of rapidly growing mycobacteria in Taiwan.
AID445286	Antibacterial activity against Mycobacterium avium 724S by broth dilution method	2009	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 19, Issue:22	Synthesis of new sugar derivatives and evaluation of their antibacterial activities against Mycobacterium tuberculosis.
AID556754	Bactericidal activity against sodA, sodB gene-deficient Escherichia coli K-12 3156 after 18 hrs	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	Contribution of oxidative damage to antimicrobial lethality.
AID1906417	Antibacterial activity against imipenem resistant Klebsiella pneumoniae ATCC BAA 1705 assessed as reduction in microbial growth incubated for 24 hrs by microbroth dilution method	2022	European journal of medicinal chemistry, May-05, Volume: 235	Amphiphilic cyclic peptide [W
AID369074	Antimicrobial activity against Pseudomonas aeruginosa ATCC 13525 after 24 hrs by MTT assay	2009	Bioorganic & medicinal chemistry, Feb-01, Volume: 17, Issue:3	Synthesis, structure and antibacterial activity of new 2-(1-(2-(substituted-phenyl)-5-methyloxazol-4-yl)-3-(2-substitued-phenyl)-4,5-dihydro-1H-pyrazol-5-yl)-7-substitued-1,2,3,4-tetrahydroisoquinoline derivatives.
AID1077164	Antibacterial activity against Escherichia coli after 12 hrs by MTT assay	2014	European journal of medicinal chemistry, Apr-09, Volume: 76	Design and synthesis of 2-styryl of 5-Nitroimidazole derivatives and antimicrobial activities as FabH inhibitors.
AID1207011	Antibacterial activity against Micrococcus luteus assessed as growth inhibition at 5 ug/disc after 24 hrs by disc diffusion method	2015	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 25, Issue:12	An antibacterial ortho-quinone diterpenoid and its derivatives from Caryopteris mongolica.
AID278241	Antimicrobial activity against Salmonella enterica serovar Typhimurium S21-3 gyrA+ with ParC S80I mutation	2007	Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2	Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials.
AID1624152	Antitubercular activity against multidrug-resistant Mycobacterium tuberculosis isolate 4 after 7 days	2019	European journal of medicinal chemistry, Feb-15, Volume: 164	Synthesis and evaluation of α-aminoacyl amides as antitubercular agents effective on drug resistant tuberculosis.
AID424831	Antibacterial activity against kanamycin-resistant and fusidic acid-susceptible Staphylococcus aureus AH416 harboring deletion of nucleotide 395-398 in rplF gene after 18 to 24 hrs by Etest strip assay	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID556568	Antimicrobial activity against katE gene-deficient Escherichia coli K-12 3202 by broth dilution method	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	Contribution of oxidative damage to antimicrobial lethality.
AID560248	Antibacterial activity against Staphylococcus aureus RN4220 harboring aadD, tet(L), dfrK and vga(C) gene by CLSI method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Novel ABC transporter gene, vga(C), located on a multiresistance plasmid from a porcine methicillin-resistant Staphylococcus aureus ST398 strain.
AID348956	Antibacterial activity against Bacillus subtilis after 24 hrs by MTT assay	2008	European journal of medicinal chemistry, Jul, Volume: 43, Issue:7	Synthesis and antimicrobial activities of 7-O-modified genistein derivatives.
AID1176774	Antimicrobial activity against Escherichia coli ATCC 35218 after 24 hrs by broth microdilution method	2015	Journal of natural products, Jan-23, Volume: 78, Issue:1	Structure and antimicrobial activity of phloroglucinol derivatives from Achyrocline satureioides.
AID424610	Antibacterial activity against kanamycin-resistant and fusidic acid-susceptible Staphylococcus aureus AH421 harboring Pro404Arg mutation in fusA gene after 18 to 24 hrs by Etest strip assay	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID1287514	Antibacterial activity against Pseudomonas fluorescens NCIM 2036 after 8 hrs	2016	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 26, Issue:7	Synthesis, biological evaluation and molecular docking study of some novel indole and pyridine based 1,3,4-oxadiazole derivatives as potential antitubercular agents.
AID1413337	Antifungal activity against Fusarium graminearum B-4-5A	2018	MedChemComm, Jun-01, Volume: 9, Issue:6	Antifungal amphiphilic kanamycins: new life for an old drug.
AID1890845	Selectivity index, ratio of MIC50 for antimycobacterial activity against Mycobacterium smegmatis mc2 155 harbouring pMyC empty vector to MIC50 for antimycobacterial activity against wild type Mycobacterium smegmatis mc2 155	2022	Bioorganic & medicinal chemistry letters, 05-15, Volume: 64	Design, synthesis and antibacterial activity against pathogenic mycobacteria of conjugated hydroxamic acids, hydrazides and O-alkyl/O-acyl protected hydroxamic derivatives.
AID1079940	Granulomatous liver disease, proven histopathologically. Value is number of references indexed. [column 'GRAN' in source]
AID425071	Antimicrobial activity against Escherichia coli J53-AzR in presence of IPTG	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Complex class 1 integrons with diverse variable regions, including aac(6')-Ib-cr, and a novel allele, qnrB10, associated with ISCR1 in clinical enterobacterial isolates from Argentina.
AID278259	Antimicrobial activity against Salmonella enterica serovar Typhimurium CS9 tolC::Kan with GyrA S83F, D87N, ParC S80I mutation	2007	Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2	Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials.
AID283536	Antibacterial activity against Pseudomonas aeruginosa FE53U with inactivated mexZ and galU genes by microdilution method	2007	Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3	Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides.
AID520873	Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus saprophyticus isolate TSU69 isolated from genitourinary tracts of acute cystitis patient after 24 hrs at 35 degC by agar dilution method	2008	Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6	Methicillin-resistant Staphylococcus saprophyticus isolates carrying staphylococcal cassette chromosome mec have emerged in urogenital tract infections.
AID1629130	Antimicrobial activity against aminoglycoside-resistant Burkholderia cepacia ATCC 25416 measured after 24 hrs by double-dilution method	2016	Journal of medicinal chemistry, 09-08, Volume: 59, Issue:17	Effects of 5-O-Ribosylation of Aminoglycosides on Antimicrobial Activity and Selective Perturbation of Bacterial Translation.
AID774298	Antimycobacterial activity against rifampin-resistant Mycobacterium tuberculosis ATCC 35838	2013	Journal of natural products, Oct-25, Volume: 76, Issue:10	Chlorinated coumarins from the polypore mushroom Fomitopsis officinalis and their activity against Mycobacterium tuberculosis.
AID348958	Antibacterial activity against Pseudomonas fluorescens after 24 hrs by MTT assay	2008	European journal of medicinal chemistry, Jul, Volume: 43, Issue:7	Synthesis and antimicrobial activities of 7-O-modified genistein derivatives.
AID1617678	Antibacterial activity against Staphylococcus aureus ATCC 292132 by CLSI based two-fold serial dilution method
AID278541	Antimicrobial activity against 60 min 1 M HCl-stressed Bifidobacterium longum R0175 after 18 hrs	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID540927	Antimicrobial activity against Streptomyces coelicolor 1147 after 48 hrs	2009	Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3	A novel insertion mutation in Streptomyces coelicolor ribosomal S12 protein results in paromomycin resistance and antibiotic overproduction.
AID556755	Bactericidal activity against katG gene-deficient Escherichia coli K-12 3157 after 18 hrs	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	Contribution of oxidative damage to antimicrobial lethality.
AID1202741	Antimicrobial activity against Staphylococcus aureus assessed as reduction in bacterial growth incubated for 48 hrs by microbroth dilution method	2015	Journal of natural products, Feb-27, Volume: 78, Issue:2	Prenylated benzophenones from Triadenum japonicum.
AID274302	Inhibition of protein synthesis in Escherichia coli S30 extracts by coupled transcription-translation assay	2006	Bioorganic & medicinal chemistry letters, Oct-15, Volume: 16, Issue:20	Structure-activity relationships of novel antibacterial translation inhibitors: 3,5-diamino-piperidinyl triazines.
AID295899	Antibacterial activity against Pseudomonas fluorescens ATCC 13525 after 24 hrs by MTT method	2007	Bioorganic & medicinal chemistry, Jun-15, Volume: 15, Issue:12	Synthesis, structure, and structure-activity relationship analysis of enamines as potential antibacterials.
AID278262	Antimicrobial activity against Salmonella enterica serovar Typhimurium CHS14 acrAB::Kan with GyrA D87G mutation	2007	Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2	Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials.
AID1169516	Antibacterial activity against Bacillus subtilis after 24 hrs by MTT method	2014	Bioorganic & medicinal chemistry letters, Sep-28	Design, synthesis and biological evaluation of metronidazole-thiazole derivatives as antibacterial inhibitors.
AID1169516	Antibacterial activity against Bacillus subtilis after 24 hrs by MTT method	2014	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22	Design, synthesis and biological evaluation of metronidazole-thiazole derivatives as antibacterial inhibitors.
AID1207002	Antibacterial activity against Staphylococcus aureus assessed as growth inhibition at 5 ug/disc after 24 hrs by disc diffusion method	2015	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 25, Issue:12	An antibacterial ortho-quinone diterpenoid and its derivatives from Caryopteris mongolica.
AID1337800	Antibacterial activity against of Staphylococcus aureus NCIM 2010 measured after 12 hrs	2017	European journal of medicinal chemistry, Jan-05, Volume: 125	Quinolidene-rhodanine conjugates: Facile synthesis and biological evaluation.
AID1265787	Antibacterial activity against methicillin-resistant Staphylococcus aureus by microdilution method	2015	Journal of medicinal chemistry, Dec-10, Volume: 58, Issue:23	Synthesis and Bioactivities of Kanamycin B-Derived Cationic Amphiphiles.
AID145295	Tested for antibacterial activity against Mycobacterium tuberculosis H37Rv isonicotinic acid hydrazide-resistant strain	1985	Journal of medicinal chemistry, Dec, Volume: 28, Issue:12	Synthesis and antibacterial activity of 2,2'-dithiobis(benzamide) derivatives against Mycobacterium species.
AID278552	Antimicrobial activity against 90 mins oxgall-stressed Bifidobacterium longum ATCC 15707 after 18 hrs	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID521580	Antibacterial activity against Salmonella enterica serovars Typhimurium ATCC 14028 assessed as log reduction in viable counts at 150 ug/ml after 1hr	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	Aminoglycosides affect intracellular Salmonella enterica serovars typhimurium and virchow.
AID428873	Antibacterial activity against Escherichia coli JM109 carrying pMCL210 by agar dilution method	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Novel plasmid-mediated 16S rRNA m1A1408 methyltransferase, NpmA, found in a clinically isolated Escherichia coli strain resistant to structurally diverse aminoglycosides.
AID1730993	Antitubercular activity against isoniazid/rifampin resistance Mycobacterium tuberculosis KZN494 by MABA assay	2021	European journal of medicinal chemistry, Mar-05, Volume: 213	Design and synthesis of mycobacterial pks13 inhibitors: Conformationally rigid tetracyclic molecules.
AID1169517	Inhibition of Escherichia coli FabH	2014	Bioorganic & medicinal chemistry letters, Sep-28	Design, synthesis and biological evaluation of metronidazole-thiazole derivatives as antibacterial inhibitors.
AID1169517	Inhibition of Escherichia coli FabH	2014	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22	Design, synthesis and biological evaluation of metronidazole-thiazole derivatives as antibacterial inhibitors.
AID510748	Antibacterial activity against Escherichia coli AG102MB harboring naive acrB gene	2010	Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3	Single nucleotide polymorphism analysis of the major tripartite multidrug efflux pump of Escherichia coli: functional conservation in disparate animal reservoirs despite exposure to antimicrobial chemotherapy.
AID278553	Antimicrobial activity against 90 mins oxgall-stressed Bifidobacterium longum ATCC 15708 after 18 hrs	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID625291	Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver function tests abnormal	2011	PLoS computational biology, Dec, Volume: 7, Issue:12	Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID290148	Antifungal activity against Aspergillus niger after 48 hrs by MTT colorimetric method	2007	European journal of medicinal chemistry, Apr, Volume: 42, Issue:4	Synthesis and antimicrobial activities of Schiff bases derived from 5-chloro-salicylaldehyde.
AID1629128	Antimicrobial activity against Escherichia coli ATCC 25922 measured after 24 hrs by double-dilution method	2016	Journal of medicinal chemistry, 09-08, Volume: 59, Issue:17	Effects of 5-O-Ribosylation of Aminoglycosides on Antimicrobial Activity and Selective Perturbation of Bacterial Translation.
AID1663463	Antibacterial activity against Staphylococcus aureus ATCC 6538 incubated for 16 hrs by broth microdilution method	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Antibacterial Pentacyclic Polyketides from a Soil-Derived
AID537734	Antifungal activity against yeast AD1-8u expressing Candida albicans CaMdr1p by agar disk diffusion assay	2010	European journal of medicinal chemistry, Nov, Volume: 45, Issue:11	Analysis of physico-chemical properties of substrates of ABC and MFS multidrug transporters of pathogenic Candida albicans.
AID1348084	Antimicrobial activity against Candida albicans ATCC 10231 assessed as zone of inhibition at 50 ug per disc after 48 hrs by disc diffusion assay	2018	European journal of medicinal chemistry, Jan-01, Volume: 143	Synthesis of new 1-benzyl tetrahydropyridinylidene ammonium salts and their antimicrobial and anticellular activities.
AID445290	Antibacterial activity against Escherichia coli by broth dilution method	2009	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 19, Issue:22	Synthesis of new sugar derivatives and evaluation of their antibacterial activities against Mycobacterium tuberculosis.
AID1326388	Antibacterial activity against Bacillus subtilis P10A derived after 10 passage in presence of JBIR-100 after 16 to 18 hrs by microbroth dilution assay relative to Bacillus subtilis ATCC 47096	2016	Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24	Biological characterization of the hygrobafilomycin antibiotic JBIR-100 and bioinformatic insights into the hygrolide family of natural products.
AID1349917	Antimicrobial activity against Mycobacterium smegmatis DSM 44200 after 16 to 48 hrs by serial dilution method	2018	Journal of natural products, 02-23, Volume: 81, Issue:2	Cysteine-Derived Pleurotin Congeners from the Nematode-Trapping Basidiomycete Hohenbuehelia grisea.
AID405816	Antimicrobial activity against Escherichia coli DH5alpha harboring recombinant pIMPAR31	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	Characterization of an integron carrying blaIMP-1 and a new aminoglycoside resistance gene, aac(6')-31, and its dissemination among genetically unrelated clinical isolates in a Brazilian hospital.
AID534419	Antibacterial activity against Mycobacterium bovis BCG-Connaught	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Susceptibility of Mycobacterium bovis BCG vaccine strains to antituberculous antibiotics.
AID601496	Antibacterial activity against Klebsiella pneumoniae MTCC 139 at 30 ug/disc after 24 hrs	2011	European journal of medicinal chemistry, Jun, Volume: 46, Issue:6	Evaluation of antioxidant and antimicrobial activities of Bergenin and its derivatives obtained by chemoenzymatic synthesis.
AID522879	Antibacterial activity against uropathogenic Escherichia coli UTI89 infected in human 5637 cells assessed as decrease in intracellular bacterial level at 1000 to 3000 ug/ml after 12 hrs by serial dilution method	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Persistence of uropathogenic Escherichia coli in the face of multiple antibiotics.
AID326534	Antimicrobial activity against Mycobacterium chelonae after 3 to 5 days by broth microdilution method	2007	Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5	In Vitro activities of isepamicin, other aminoglycosides, and capreomycin against clinical isolates of rapidly growing mycobacteria in Taiwan.
AID326537	Antimicrobial activity against Mycobacterium abscessus R31 isolate after 3 to 5 days by broth microdilution method	2007	Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5	In Vitro activities of isepamicin, other aminoglycosides, and capreomycin against clinical isolates of rapidly growing mycobacteria in Taiwan.
AID278806	Antimicrobial activity against Stenotrophomonas maltophilia K279a (aph FS) mutant	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Aph(3')-IIc, an aminoglycoside resistance determinant from Stenotrophomonas maltophilia.
AID326540	Antimicrobial activity against Mycobacterium abscessus NTU459 isolate after 3 to 5 days by broth microdilution method	2007	Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5	In Vitro activities of isepamicin, other aminoglycosides, and capreomycin against clinical isolates of rapidly growing mycobacteria in Taiwan.
AID1455935	Antibacterial activity against Bacillus subtilis after 48 hrs by broth micro-dilution method	2017	Journal of natural products, 02-24, Volume: 80, Issue:2	Nabscessins A and B, Aminocyclitol Derivatives from Nocardia abscessus IFM 10029
AID325446	Antibacterial activity against Salmonella enterica serovar Typhimurium LT2 after 14 to 16 hrs by broth dilution method	2007	Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6	Polyamine effects on antibiotic susceptibility in bacteria.
AID523021	Activity at aminoglycoside 3'-phosphotransferase 1B by PK/LDH-coupled assay in presence of GTP	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Nucleotide selectivity of antibiotic kinases.
AID1113098	Antibacterial activity against Escherichia coli after 24 hr by microdilution method	2013	Journal of agricultural and food chemistry, Mar-27, Volume: 61, Issue:12	Isolation and characterization of new p-Terphenyls with antifungal, antibacterial, and antioxidant activities from halophilic actinomycete Nocardiopsis gilva YIM 90087.
AID647790	Antibacterial activity Bacillus subtilis at 40 ug/disc after 24 hrs by agar disc diffusion method	2012	European journal of medicinal chemistry, Apr, Volume: 50	Synthesis of new α aminophosphonate system bearing Indazole moiety and their biological activity.
AID424584	Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH367 (SCV-39) harboring Gly664Ser mutation in fusA gene after 18 to 24 hrs by Etest strip assay	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID278230	Antimicrobial activity against Salmonella enterica serovar Typhimurium S21 acrAB::Kan	2007	Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2	Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials.
AID1478527	Antibacterial activity against Escherichia coli BL21 by double microdilution method	2017	Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11	Covalently linked kanamycin - Ciprofloxacin hybrid antibiotics as a tool to fight bacterial resistance.
AID1887299	Antibacterial activity against Bacillus subtilis ATCC 11774 assessed as inhibition of bacterial growth incubated for 24 hrs by optical density based analysis	2022	Journal of natural products, 09-23, Volume: 85, Issue:9	Total Syntheses and Antibacterial Evaluations of Neocyclomorusin and Related Flavones.
AID1869576	Bactericidal activity against Enterobacter cloacae DSM 30054 assessed as reduction in colony count and measured after 3 days by agar diffusion assay	2022	Journal of natural products, 06-24, Volume: 85, Issue:6	Triculamin: An Unusual Lasso Peptide with Potent Antimycobacterial Activity.
AID1710564	Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 assessed as reduction in bacterial growth incubated for 15 to 20 hrs by broth microdilution method	2018	MedChemComm, Jul-01, Volume: 9, Issue:7	Targeting miRNA by tunable small molecule binders: peptidic aminosugar mediated interference in miR-21 biogenesis reverts epithelial to mesenchymal transition.
AID1164942	Antimicrobial activity against methicillin-sensitive Staphylococcus aureus ATCC 29213 by microbroth dilution method	2014	Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20	Synthesis, structure-activity relationship studies, and antibacterial evaluation of 4-chromanones and chalcones, as well as olympicin A and derivatives.
AID293865	Antimicrobial activity against Escherichia coli ATCC 25922 after 24 hrs by two fold dilution method	2007	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6	Synthesis of pseudopeptides based L-tryptophan as a potential antimicrobial agent.
AID625285	Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatic necrosis	2011	PLoS computational biology, Dec, Volume: 7, Issue:12	Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID1585672	Antibacterial activity against methicillin-resistant Staphylococcus haemolyticus assessed as zone of inhibition at 30 ug/mL after 24 hrs by agar disc diffusion method	2019	European journal of medicinal chemistry, Jan-15, Volume: 162	Discovery of novel arylethenesulfonyl fluorides as potential candidates against methicillin-resistant of Staphylococcus aureus (MRSA) for overcoming multidrug resistance of bacterial infections.
AID326552	Antimicrobial activity against Mycobacterium fortuitum V61 isolate after 3 to 5 days by broth microdilution method	2007	Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5	In Vitro activities of isepamicin, other aminoglycosides, and capreomycin against clinical isolates of rapidly growing mycobacteria in Taiwan.
AID1617682	Antibacterial activity against Bacillus subtilis BS01 by CLSI based two-fold serial dilution method
AID206014	Minimum inhibitory concentration (MIC) was measured against Staphylococcus aureus.	1995	Journal of medicinal chemistry, Nov-10, Volume: 38, Issue:23	Synthesis and antimicrobial and toxicological studies of amino acid and peptide derivatives of kanamycin A and netilmicin.
AID1055365	Antibacterial activity against Staphylococcus epidermidis after 18 hrs by turbidity assay	2013	Journal of natural products, Nov-22, Volume: 76, Issue:11	Stereochemical assignment of the fungal metabolites pestalotiopsones D and E through enantiopure synthesis.
AID163076	Antibacterial activity expressed as MIC value was determined on Proteus stuartii A-21210 organism	1986	Journal of medicinal chemistry, May, Volume: 29, Issue:5	Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin.
AID584330	Antibacterial activity against ygiBC, yjfMC, gspS deficient Escherichia coli GD108	2010	Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12	Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics.
AID1250523	Antibacterial activity against Escherichia coli ATCC 8739 after 24 hr by MTT assay	2015	European journal of medicinal chemistry, Sep-18, Volume: 102	Synthesis and evaluation of new tyrosyl-tRNA synthetase inhibitors as antibacterial agents based on a N2-(arylacetyl)glycinanilide scaffold.
AID326543	Antimicrobial activity against Mycobacterium abscessus R47 isolate after 3 to 5 days by broth microdilution method	2007	Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5	In Vitro activities of isepamicin, other aminoglycosides, and capreomycin against clinical isolates of rapidly growing mycobacteria in Taiwan.
AID1105401	Antibacterial activity against Bacillus pumilus MTCC 2466 assessed as growth inhibition at 25 ug/disk after 24 hr by disk diffusion method	2013	European journal of medicinal chemistry, Jan, Volume: 59	Microwave synthesis, characterization and bio-efficacy evaluation of novel chalcone based 6-carbethoxy-2-cyclohexen-1-one and 2H-indazol-3-ol derivatives.
AID1263042	Antibacterial activity against Burkholderia thailandensis E264 at 0.1 mM after 24 to 48 hrs by Kirby-Bauer disc diffusion susceptibility test	2015	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 25, Issue:24	Synthesis and biological evaluation of pyrazolopyrimidines as potential antibacterial agents.
AID1193541	Antibacterial activity against Escherichia coli ATCC 25922 at 100 ug after 24 hrs	2015	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 25, Issue:7	Synthesis of 3-azabicyclo[3.2.2]nonanes and their antiprotozoal activities.
AID1105400	Antibacterial activity against Klebsiella pneumoniae MTCC 7028 assessed as growth inhibition at 25 ug/disk after 24 hr by disk diffusion method	2013	European journal of medicinal chemistry, Jan, Volume: 59	Microwave synthesis, characterization and bio-efficacy evaluation of novel chalcone based 6-carbethoxy-2-cyclohexen-1-one and 2H-indazol-3-ol derivatives.
AID278538	Antimicrobial activity against 60 min 1 M HCl-stressed Bifidobacterium breve R0070 after 18 hrs	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID532985	Antibacterial activity against Escherichia coli MG1655	2010	Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8	N-acetylcysteine-mediated modulation of bacterial antibiotic susceptibility.
AID207042	Antibacterial activity expressed as MIC value was determined on Staphylococcus aureus A-22231 organism	1986	Journal of medicinal chemistry, May, Volume: 29, Issue:5	Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin.
AID1478526	Antibacterial activity against aminoglycosides-susceptible Staphylococcus epidermidis by double microdilution method	2017	Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11	Covalently linked kanamycin - Ciprofloxacin hybrid antibiotics as a tool to fight bacterial resistance.
AID524382	Antibacterial activity against Escherichia coli NKE160 harboring deletion mutation in acrB protein and vector expressing tolC gene	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Effect of NlpE overproduction on multidrug resistance in Escherichia coli.
AID326550	Antimicrobial activity against Mycobacterium abscessus V120 isolate after 3 to 5 days by broth microdilution method	2007	Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5	In Vitro activities of isepamicin, other aminoglycosides, and capreomycin against clinical isolates of rapidly growing mycobacteria in Taiwan.
AID1636357	Drug activation in human Hep3B cells assessed as human CYP3A4-mediated drug metabolism-induced cytotoxicity measured as decrease in cell viability at 300 uM pre-incubated with BSO for 18 hrs followed by incubation with compound for 3 hrs in presence of NA	2016	Bioorganic & medicinal chemistry letters, 08-15, Volume: 26, Issue:16	Development of a cell viability assay to assess drug metabolite structure-toxicity relationships.
AID587759	Antimicrobial activity against Mycobacterium ulcerans Mu1059 expressing luxAB from vibrio harveyi infected BALB/c mouse assessed as reduction in foodpad CFU count after 4 weeks	2011	Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1	Using bioluminescence to monitor treatment response in real time in mice with Mycobacterium ulcerans infection.
AID1868103	Antibacterial activity against Mycobacterium smegmatis ATCC 607 assessed as inhibition of visible bacterial growth incubated for 48 hrs by CLSI protocol based assay	2022	Journal of natural products, 05-27, Volume: 85, Issue:5	Enceleamycins A-C, Furo-Naphthoquinones from
AID625286	Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatitis	2011	PLoS computational biology, Dec, Volume: 7, Issue:12	Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID697852	Inhibition of electric eel AChE at 2 mg/ml by Ellman's method	2012	Bioorganic & medicinal chemistry, Nov-15, Volume: 20, Issue:22	Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
AID1299588	Antibiofilm activity against Pseudomonas aeruginosa PAO1 ATCC 47085 at < 1024 ug/ml after 24 hrs by crystal violet staining-based spectrophotometry	2016	Journal of medicinal chemistry, Apr-14, Volume: 59, Issue:7	Antibacterial Diamines Targeting Bacterial Membranes.
AID565230	Antimicrobial activity against Mycobacterium chelonae 9917 by resazurine microtiter assay	2009	Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9	Role of porins in the susceptibility of Mycobacterium smegmatis and Mycobacterium chelonae to aldehyde-based disinfectants and drugs.
AID569258	Antimycobacterial activity against Mycobacterium avium subsp. hominissuis 104	2011	Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3	Synthesis and evaluation of anti-tubercular activity of new dithiocarbamate sugar derivatives.
AID342022	Antibacterial activity against plasmid pK29 transconjugant Escherichia coli J53 by broth microdilution test	2007	Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8	Sequencing and comparative genomic analysis of pK29, a 269-kilobase conjugative plasmid encoding CMY-8 and CTX-M-3 beta-lactamases in Klebsiella pneumoniae.
AID476720	Antibacterial activity against Escherichia coli ATCC 35218 after 24 hrs by colorimetric method using dye MTT	2010	Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7	Synthesis, molecular modeling and biological evaluation of PSB as targeted antibiotics.
AID521590	Antibacterial activity against Salmonella enterica serovars virchow isolate 101591 at pH 5.7 by broth dilution method	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	Aminoglycosides affect intracellular Salmonella enterica serovars typhimurium and virchow.
AID1478524	Antibacterial activity against aminoglycosides-susceptible Escherichia coli 25922 by double microdilution method	2017	Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11	Covalently linked kanamycin - Ciprofloxacin hybrid antibiotics as a tool to fight bacterial resistance.
AID1765580	Antibacterial activity against Acinetobacter baumannii ATCC 19606 incubated for 18 hrs by CLSI based broth dilution method	2021	Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15	Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1296451	Inhibition of RNA biosynthesis in Mycobacterium tuberculosis H37Ra assessed as reduction of [14C]-uracil incorporation at 5 ug/ml preincubated for 1 hr followed by radiolabeling with [14C]-uracil for 24 hrs by scintillation spectrometry	2016	Journal of medicinal chemistry, Mar-24, Volume: 59, Issue:6	Development of 3,5-Dinitrobenzylsulfanyl-1,3,4-oxadiazoles and Thiadiazoles as Selective Antitubercular Agents Active Against Replicating and Nonreplicating Mycobacterium tuberculosis.
AID1890844	Antimycobacterial activity against Mycobacterium smegmatis mc2 155 harbouring pMyC::PDFMtb overexpression mutant assessed as inhibition of mycobacterial growth incubated for 3 to 5 days by resazurin microtiter assay	2022	Bioorganic & medicinal chemistry letters, 05-15, Volume: 64	Design, synthesis and antibacterial activity against pathogenic mycobacteria of conjugated hydroxamic acids, hydrazides and O-alkyl/O-acyl protected hydroxamic derivatives.
AID534338	Antimicrobial activity against Burkholderia pseudomallei Bp250 harboring mini-Tn7T-bpeA+B+ -oprB+ after 24 hrs by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8	The BpeAB-OprB efflux pump of Burkholderia pseudomallei 1026b does not play a role in quorum sensing, virulence factor production, or extrusion of aminoglycosides but is a broad-spectrum drug efflux system.
AID1617941	Antibacterial activity against Micrococcus luteus ATCC 15307 after 16 to 48 hrs	2019	Journal of natural products, 12-27, Volume: 82, Issue:12	Structure Determination, Functional Characterization, and Biosynthetic Implications of Nybomycin Metabolites from a Mining Reclamation Site-Associated
AID290147	Antibacterial activity against Staphylococcus aureus after 24 hrs by MTT colorimetric method	2007	European journal of medicinal chemistry, Apr, Volume: 42, Issue:4	Synthesis and antimicrobial activities of Schiff bases derived from 5-chloro-salicylaldehyde.
AID520703	Antibacterial activity against aphA-3 positive tetracycline resistant Streptococcus pneumoniae clinical isolate expressing Tn6003 carrying erm(B)and tet(M) gene at 1000 ug by disk diffusion method	2008	Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4	erm(B)-carrying elements in tetracycline-resistant pneumococci and correspondence between Tn1545 and Tn6003.
AID1287515	Antibacterial activity against Staphylococcus aureus NCIM 2010 after 12 hrs	2016	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 26, Issue:7	Synthesis, biological evaluation and molecular docking study of some novel indole and pyridine based 1,3,4-oxadiazole derivatives as potential antitubercular agents.
AID325443	Antibacterial activity against Escherichia coli K10 after 14 to 16 hrs by broth dilution method	2007	Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6	Polyamine effects on antibiotic susceptibility in bacteria.
AID1306202	Antibacterial activity against Escherichia coli ATCC 25922 after 18 hrs by microbroth dilution assay	2016	Bioorganic & medicinal chemistry, 07-15, Volume: 24, Issue:14	The influence of halogen substituents on the biological properties of sulfur-containing flavonoids.
AID1182153	Ratio of MIC99 for Mycobacterium smegmatis to ratio of MIC99 for Mycobacterium smegmatis in presence of nor-chlorpromazine	2014	Bioorganic & medicinal chemistry, Aug-15, Volume: 22, Issue:16	Pharmacologically active metabolites, combination screening and target identification-driven drug repositioning in antituberculosis drug discovery.
AID537736	Antifungal activity against yeast AD1-8u expressing Candida albicans CaCdr1p by agar disk diffusion assay	2010	European journal of medicinal chemistry, Nov, Volume: 45, Issue:11	Analysis of physico-chemical properties of substrates of ABC and MFS multidrug transporters of pathogenic Candida albicans.
AID523019	Activity at aminoglycoside 3'-phosphotransferase 1B by PK/LDH-coupled assay in presence of ATP	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Nucleotide selectivity of antibiotic kinases.
AID501182	Antimicrobial activity against Escherichia coli 442 at 30 ug after 18 hrs by agar diffusion method	2009	Journal of natural products, Oct, Volume: 72, Issue:10	Norselic acids A-E, highly oxidized anti-infective steroids that deter mesograzer predation, from the Antarctic sponge Crella sp.
AID405081	Antimicrobial activity against Escherichia coli CAG12177 by agar dilution method	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	Biochemical characterization of PER-2 and genetic environment of blaPER-2.
AID1056539	Antibacterial activity against Acinetobacter baumannii ATCC 19606 by broth microdilution method	2013	Journal of natural products, Dec-27, Volume: 76, Issue:12	Cytotoxic and antibacterial marfuraquinocins from the deep South China Sea-derived Streptomyces niveus SCSIO 3406.
AID424348	Antibacterial activity against fusidic acid-resistant Staphylococcus aureus AH202 harboring CTG start codon at nucleotide 1 in rplF gene after 18 to 24 hrs by Etest strip assay	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID1413336	Antifungal activity against sensitive Candida parapsilosis	2018	MedChemComm, Jun-01, Volume: 9, Issue:6	Antifungal amphiphilic kanamycins: new life for an old drug.
AID584114	Antibacterial activity against Escherichia coli KAM32 harboring Staphylococcus aureus cloned pSP72 lmrS by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12	LmrS is a multidrug efflux pump of the major facilitator superfamily from Staphylococcus aureus.
AID520423	Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus saprophyticus isolate TSU18 isolated from genitourinary tracts of acute cystitis patient after 24 hrs at 35 degC by agar dilution method	2008	Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6	Methicillin-resistant Staphylococcus saprophyticus isolates carrying staphylococcal cassette chromosome mec have emerged in urogenital tract infections.
AID1055362	Antibacterial activity against Mycobacterium smegmatis after 18 hrs by turbidity assay	2013	Journal of natural products, Nov-22, Volume: 76, Issue:11	Stereochemical assignment of the fungal metabolites pestalotiopsones D and E through enantiopure synthesis.
AID424615	Antibacterial activity against kanamycin-resistant and fusidic acid-susceptible Staphylococcus aureus AH297 harboring Ser660Pro mutation in fusA gene after 18 to 24 hrs by Etest strip assay	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID1862200	Antimycobacterial activity against clinical isolate multidrug resistant Mycobacterium tuberculosis H37Rv assessed as bacterial growth inhibition	2022	Bioorganic & medicinal chemistry letters, 09-15, Volume: 72	Discovery and preclinical evaluations of JBD0131, a novel nitrodihydro-imidazooxazole anti-tuberculosis agent.
AID424592	Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH392 (SCV-64) harboring -1 frameshift mutation at nucleotide 383 in rplF gene after 18 to 24 hrs by Etest strip assay	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID1455938	Antifungal activity against Candida albicans after 48 hrs by broth micro-dilution method	2017	Journal of natural products, 02-24, Volume: 80, Issue:2	Nabscessins A and B, Aminocyclitol Derivatives from Nocardia abscessus IFM 10029
AID1473738	Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to 20 mins by membrane vesicle transport assay	2013	Toxicological sciences : an official journal of the Society of Toxicology, Nov, Volume: 136, Issue:1	A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
AID1055951	Antibacterial activity against Acinetobacter baumannii ATCC BAA-747 after 16 hrs	2013	Journal of natural products, Nov-22, Volume: 76, Issue:11	Hytramycins V and I, anti-Mycobacterium tuberculosis hexapeptides from a Streptomyces hygroscopicus strain.
AID126450	Dissociation constant for binding to mitochondrial 12S rRNA construct M3 was determined	2002	Bioorganic & medicinal chemistry letters, Aug-19, Volume: 12, Issue:16	Decoding region bubble size and aminoglycoside antibiotic binding.
AID293205	Antibacterial activity against Escherichia coli ATCC 25922 by disc diffusion method	2007	Bioorganic & medicinal chemistry, Feb-01, Volume: 15, Issue:3	Parallel solid synthesis of inhibitors of the essential cell division FtsZ enzyme as a new potential class of antibacterials.
AID1167356	Antibacterial activity against Escherichia coli D21 IpxC101/tolC deletion mutant after 18 to 24 hrs by two-fold broth microdilution method	2014	Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21	Design, synthesis, and antibacterial properties of dual-ligand inhibitors of acetyl-CoA carboxylase.
AID404903	Antibacterial activity against Streptococcus bovis ATCC 33317 by agar dilution method	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	High-level gentamicin resistance mediated by a Tn4001-like transposon in seven nonclonal hospital isolates of Streptococcus pasteurianus.
AID1164943	Antimicrobial activity against Escherichia coli K-12 by microbroth dilution method	2014	Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20	Synthesis, structure-activity relationship studies, and antibacterial evaluation of 4-chromanones and chalcones, as well as olympicin A and derivatives.
AID1473741	Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and GSH measured after 20 mins by membrane vesicle transport assay	2013	Toxicological sciences : an official journal of the Society of Toxicology, Nov, Volume: 136, Issue:1	A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
AID1868108	Antibacterial activity against Escherichia coli ATCC 8739 assessed as inhibition of visible bacterial growth incubated for 18 hrs by CLSI protocol based assay	2022	Journal of natural products, 05-27, Volume: 85, Issue:5	Enceleamycins A-C, Furo-Naphthoquinones from
AID1271378	Antimicrobial activity against Gram-positive Bacillus subtilis 168 after 16 to 24 hrs by micro-dilution method	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Synthesis and Biological Activity of Mono- and Di-N-acylated Aminoglycosides.
AID1225388	Antibacterial activity against Escherichia coli transformed with plasmid carrying MG1655 deltaBC/pABM by p-iodonitrotetrazolium chloride colorimetric assay	2015	Journal of natural products, Mar-27, Volume: 78, Issue:3	Enhancement of antibiotic activity against multidrug-resistant bacteria by the efflux pump inhibitor 3,4-dibromopyrrole-2,5-dione isolated from a Pseudoalteromonas sp.
AID1868102	Antibacterial activity against Listeria monocytogenes ATCC19111 assessed as inhibition of visible bacterial growth incubated for 18 hrs by CLSI protocol based assay	2022	Journal of natural products, 05-27, Volume: 85, Issue:5	Enceleamycins A-C, Furo-Naphthoquinones from
AID1056540	Antibacterial activity against Staphylococcus aureus ATCC 29213 by broth microdilution method	2013	Journal of natural products, Dec-27, Volume: 76, Issue:12	Cytotoxic and antibacterial marfuraquinocins from the deep South China Sea-derived Streptomyces niveus SCSIO 3406.
AID1271379	Antimicrobial activity against Gram-positive Listeria monocytogenes ATCC 19115 after 16 to 24 hrs by micro-dilution method	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Synthesis and Biological Activity of Mono- and Di-N-acylated Aminoglycosides.
AID560590	Antimicrobial activity against Pseudomonas aeruginosa isolate IMCJ798 by microdilution method	2009	Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6	AAC(6')-Iaf, a novel aminoglycoside 6'-N-acetyltransferase from multidrug-resistant Pseudomonas aeruginosa clinical isolates.
AID1261214	Bacteriostatic activity against Staphylococcus aureus Mu50 after 24 hrs	2015	Bioorganic & medicinal chemistry, Nov-01, Volume: 23, Issue:21	Evaluation of small molecule SecA inhibitors against methicillin-resistant Staphylococcus aureus.
AID718275	Antimicrobial activity against Micrococcus luteus	2012	Journal of natural products, Dec-28, Volume: 75, Issue:12	Marthiapeptide A, an anti-infective and cytotoxic polythiazole cyclopeptide from a 60 L scale fermentation of the deep sea-derived Marinactinospora thermotolerans SCSIO 00652.
AID368419	Antimicrobial activity against Escherichia coli KAM32 expressing deltaacrB ydhE hsd gene by agar dilution method	2007	Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9	New plasmid-mediated fluoroquinolone efflux pump, QepA, found in an Escherichia coli clinical isolate.
AID293857	Antibacterial activity against methicillin-susceptible Staphylococcus aureus ATCC 25923 after 24 hrs by two fold dilution method	2007	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6	Synthesis of pseudopeptides based L-tryptophan as a potential antimicrobial agent.
AID1167361	Antibacterial activity against wild type Enterococcus faecalis ATCC 29212 after 18 to 24 hrs by two-fold broth microdilution method	2014	Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21	Design, synthesis, and antibacterial properties of dual-ligand inhibitors of acetyl-CoA carboxylase.
AID520872	Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus saprophyticus isolate TSU67 isolated from genitourinary tracts of acute cystitis patient after 24 hrs at 35 degC by agar dilution method	2008	Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6	Methicillin-resistant Staphylococcus saprophyticus isolates carrying staphylococcal cassette chromosome mec have emerged in urogenital tract infections.
AID1132227	Antibacterial activity against Staphylococcus aureus 210 assessed as growth inhibition by agar dilution method	1978	Journal of medicinal chemistry, Feb, Volume: 21, Issue:2	Chemical modification of 1,4-diamino-1,4-dideoxy-3-O-(4-deoxy-4-propionamido-alpha-D-glucopyranosyl)-D-glucitol.
AID1455932	Antifungal activity against Cryptococcus neoformans after 96 hrs by broth micro-dilution method	2017	Journal of natural products, 02-24, Volume: 80, Issue:2	Nabscessins A and B, Aminocyclitol Derivatives from Nocardia abscessus IFM 10029
AID1478534	Antibacterial activity against Escherichia coli XL1 blue harboring pET9d encode for APH(3')-1a resistance enzyme by double microdilution method	2017	Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11	Covalently linked kanamycin - Ciprofloxacin hybrid antibiotics as a tool to fight bacterial resistance.
AID1182140	Antitubercular activity against Mycobacterium smegmatis by checkerboard assay in presence of 7-hydroxy chlorpromazine	2014	Bioorganic & medicinal chemistry, Aug-15, Volume: 22, Issue:16	Pharmacologically active metabolites, combination screening and target identification-driven drug repositioning in antituberculosis drug discovery.
AID501207	Antimicrobial activity against Escherichia coli 389 assessed as hazy zone of inhibition at 30 ug after 18 hrs by agar diffusion method	2009	Journal of natural products, Oct, Volume: 72, Issue:10	Norselic acids A-E, highly oxidized anti-infective steroids that deter mesograzer predation, from the Antarctic sponge Crella sp.
AID1684998	Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 assessed as inhibition of bacterial growth incubated for 16 to 20 hrs by microdilution method	2021	ACS medicinal chemistry letters, Jan-14, Volume: 12, Issue:1	Enhancing Antimicrobial Peptide Potency through Multivalent Presentation on Coiled-Coil Nanofibrils.
AID544283	Antimicrobial activity against Enterococcus faecalis NKH13 harboring pMG2200-like and pMG2201-like plasmids after 24 hrs by agar dilution method	2009	Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2	Isolation of VanB-type Enterococcus faecalis strains from nosocomial infections: first report of the isolation and identification of the pheromone-responsive plasmids pMG2200, Encoding VanB-type vancomycin resistance and a Bac41-type bacteriocin, and pMG2
AID69749	Antibacterial activity expressed as MIC value was determined on Escherichia coli A-20683 organism	1986	Journal of medicinal chemistry, May, Volume: 29, Issue:5	Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin.
AID424613	Antibacterial activity against kanamycin-resistant and fusidic acid-susceptible Staphylococcus aureus AH287 harboring Ala655Glu mutation in fusA gene after 18 to 24 hrs by Etest strip assay	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID1079932	Highest frequency of moderate liver toxicity observed during clinical trials, expressed as a percentage. [column '% BIOL' in source]
AID1436941	Antibacterial activity against Staphylococcus aureus ATCC 29213 after 12 hrs	2017	Bioorganic & medicinal chemistry letters, 02-15, Volume: 27, Issue:4	Quinolidene based monocarbonyl curcumin analogues as promising antimycobacterial agents: Synthesis and molecular docking study.
AID563513	Antimicrobial activity against cetylpyridinium chloride-resistant Serratia marcescens 011 harboring plasmid STV28 expressing sdeB gene by broth dilution method	2009	Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12	Mutational upregulation of a resistance-nodulation-cell division-type multidrug efflux pump, SdeAB, upon exposure to a biocide, cetylpyridinium chloride, and antibiotic resistance in Serratia marcescens.
AID750182	Antibacterial activity against Staphylococcus aureus ATCC 6538 assessed as growth inhibition after 24 hrs by two-fold serial dilution method	2013	European journal of medicinal chemistry, Jun, Volume: 64	Synthesis and antimicrobical evaluation of a novel class of 1,3,4-thiadiazole: derivatives bearing 1,2,4-triazolo[1,5-a]pyrimidine moiety.
AID1551811	Antibacterial activity against methicillin-resistant Staphylococcus aureus incubated for 18 hrs post 30 mins pre-diffusion by disk diffusion method	2019	European journal of medicinal chemistry, Jul-01, Volume: 173	Antibacterial activity study of 1,2,4-triazole derivatives.
AID575170	Inhibition of acrAB AcrAB-TolC-mediated Nile Red efflux in Escherichia coli K-12 3-AG100 overexpressing acrAB AcrAB-TolC assessed as time needed for 50% efflux after energization with 50 mM glucose at 200 uM by spectrofluorometric assay	2010	Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9	Optimized Nile Red efflux assay of AcrAB-TolC multidrug efflux system shows competition between substrates.
AID424347	Antibacterial activity against fusidic acid-resistant Staphylococcus aureus AH199 harboring TAA stop codon at nucleotide 241 in rplF gene after 18 to 24 hrs by Etest strip assay	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID1167352	Antibacterial activity against wild type Escherichia coli D21 after 18 to 24 hrs by two-fold broth microdilution method	2014	Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21	Design, synthesis, and antibacterial properties of dual-ligand inhibitors of acetyl-CoA carboxylase.
AID364062	Antibacterial activity against Escherichia coli ATCC 35218 after 24 hrs by MTT assay	2008	European journal of medicinal chemistry, Sep, Volume: 43, Issue:9	Enamines as novel antibacterials and their structure-activity relationships.
AID278537	Antimicrobial activity against 60 min 1 M HCl-stressed Bifidobacterium breve ATCC 15700 after 18 hrs	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID1636356	Drug activation in human Hep3B cells assessed as human CYP2C9-mediated drug metabolism-induced cytotoxicity measured as decrease in cell viability at 300 uM pre-incubated with BSO for 18 hrs followed by incubation with compound for 3 hrs in presence of NA	2016	Bioorganic & medicinal chemistry letters, 08-15, Volume: 26, Issue:16	Development of a cell viability assay to assess drug metabolite structure-toxicity relationships.
AID1890843	Antimycobacterial activity against Mycobacterium smegmatis mc2 155 harbouring pMyC empty vector assessed as inhibition of mycobacterial growth incubated for 3 to 5 days by resazurin microtiter assay	2022	Bioorganic & medicinal chemistry letters, 05-15, Volume: 64	Design, synthesis and antibacterial activity against pathogenic mycobacteria of conjugated hydroxamic acids, hydrazides and O-alkyl/O-acyl protected hydroxamic derivatives.
AID647787	Antibacterial activity Klebsiella pneumoniae at 40 ug/disc after 24 hrs by agar disc diffusion method	2012	European journal of medicinal chemistry, Apr, Volume: 50	Synthesis of new α aminophosphonate system bearing Indazole moiety and their biological activity.
AID1616525	Antibacterial activity against Staphylococcus aureus ATCC 25923 assessed as growth inhibition at 0.125 mg/m by microbroth dilution method relative to control	2019	Journal of natural products, 10-25, Volume: 82, Issue:10	Polyketides from Marine-Derived
AID544272	Antimicrobial activity against Enterococcus faecalis NKH2 harboring pMG2200-like and pMG2201-like plasmids after 24 hrs by agar dilution method	2009	Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2	Isolation of VanB-type Enterococcus faecalis strains from nosocomial infections: first report of the isolation and identification of the pheromone-responsive plasmids pMG2200, Encoding VanB-type vancomycin resistance and a Bac41-type bacteriocin, and pMG2
AID1265797	Antibacterial activity against Enterobacter cloacae ATCC 13047 by microdilution method	2015	Journal of medicinal chemistry, Dec-10, Volume: 58, Issue:23	Synthesis and Bioactivities of Kanamycin B-Derived Cationic Amphiphiles.
AID1869561	Antibacterial activity against Mycobacterium smegmatis DSM 43080 assessed as reduction in bacterial growth measured after 3 days by broth microdilution method	2022	Journal of natural products, 06-24, Volume: 85, Issue:6	Triculamin: An Unusual Lasso Peptide with Potent Antimycobacterial Activity.
AID404895	Antibacterial activity against high-level gentamicin resistant Streptococcus pasteurianus SB10 isolate carrying transposon-borne resistance gene [aac(6')Ie-aph(2'')Ia] by agar dilution method	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	High-level gentamicin resistance mediated by a Tn4001-like transposon in seven nonclonal hospital isolates of Streptococcus pasteurianus.
AID244900	In-vitro minimum inhibitory concentration against the growth of Staphylococcus aureus	2005	Bioorganic & medicinal chemistry letters, Jul-01, Volume: 15, Issue:13	Synthesis of (1,4)-naphthoquinono-[3,2-c]-1H-pyrazoles and their (1,4)-naphthohydroquinone derivatives as antifungal, antibacterial, and anticancer agents.
AID1303882	Antibacterial activity against multidrug resistant Staphylococcus aureus subsp. aureus Seattle 1945 (ATCC 25923) assessed as reduction in bacterial growth incubated for 6 to 8 hrs	2016	Bioorganic & medicinal chemistry letters, 07-01, Volume: 26, Issue:13	GroEL/ES inhibitors as potential antibiotics.
AID378857	Antimalarial activity against multidrug-resistant Plasmodium falciparum K1	2006	Journal of natural products, Oct, Volume: 69, Issue:10	Integerrimides A and B, cyclic heptapeptides from the latex of Jatropha integerrima.
AID278523	Antimicrobial activity against Bifidobacterium bifidum ATCC 15696	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID599147	Antibacterial activity against Escherichia coli after 24 hrs by MTT assay	2008	European journal of medicinal chemistry, Mar, Volume: 43, Issue:3	Synthesis, crystal structure and antimicrobial activity of deoxybenzoin derivatives from genistein.
AID732422	Antimycobacterial activity Mycobacterium tuberculosis H37Rv assessed as growth inhibition measured at day 7 by broth microdilution method	2013	ACS medicinal chemistry letters, Jan-10, Volume: 4, Issue:1	Synthesis and antiplasmodial and antimycobacterial evaluation of new nitroimidazole and nitroimidazooxazine derivatives.
AID355266	Antitubercular activity against Mycobacterium tuberculosis H37Rv after 21 days by broth microdilution method	1997	Journal of natural products, Dec, Volume: 60, Issue:12	Norditerpenoids and diterpenoids from Salvia multicaulis with antituberculous activity.
AID1478528	Antibacterial activity against aminoglycosides-resistant Escherichia coli BL21 harboring pSF815 encode for bifunctional AAC(6')/APH(2\\\\\\\\\\) resistance enzyme by double microdilution method	2017	Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11	Covalently linked kanamycin - Ciprofloxacin hybrid antibiotics as a tool to fight bacterial resistance.
AID1738323	Antibacterial activity against multidrug-resistant Staphylococcus aureus NRS108 assessed as reduction in bacterial growth incubated for 16 to 18 hrs by two-fold serial dilution method	2020	European journal of medicinal chemistry, Jul-15, Volume: 198	Capsaicin derivatives with nitrothiophene substituents: Design, synthesis and antibacterial activity against multidrug-resistant S. aureus.
AID1413338	Antifungal activity against Fusarium oxysporum	2018	MedChemComm, Jun-01, Volume: 9, Issue:6	Antifungal amphiphilic kanamycins: new life for an old drug.
AID1287415	Antimycobacterial activity against Mycobacterium bovis BCG after 2 weeks	2016	European journal of medicinal chemistry, Apr-13, Volume: 112	New direct inhibitors of InhA with antimycobacterial activity based on a tetrahydropyran scaffold.
AID1562310	Antimycobacterial activity against Mycobacterium smegmatis atR8 assessed as decrease in drug resistance development at 5 ug/disc after 2 to 3 days by paper disc method	2019	European journal of medicinal chemistry, Sep-15, Volume: 178	Synthesis and antimycobacterial activity of imidazo[1,2-b][1,2,4,5]tetrazines.
AID599146	Antibacterial activity against Bacillus subtilis after 24 hrs by MTT assay	2008	European journal of medicinal chemistry, Mar, Volume: 43, Issue:3	Synthesis, crystal structure and antimicrobial activity of deoxybenzoin derivatives from genistein.
AID647789	Antibacterial activity Salmonella Typhimurium at 40 ug/disc after 24 hrs by agar disc diffusion method	2012	European journal of medicinal chemistry, Apr, Volume: 50	Synthesis of new α aminophosphonate system bearing Indazole moiety and their biological activity.
AID584339	Antibacterial activity against tolC deficient Escherichia coli GD100 presence of 10 mM of glutathione	2010	Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12	Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics.
AID293864	Antimicrobial activity against Bacillus subtilis after 24 hrs by two fold dilution method	2007	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6	Synthesis of pseudopeptides based L-tryptophan as a potential antimicrobial agent.
AID540931	Antimicrobial activity against paromomycin-resistant Streptomyces coelicolor SP1 harboring rpsL A262G and C271T mutant gene after 48 hrs	2009	Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3	A novel insertion mutation in Streptomyces coelicolor ribosomal S12 protein results in paromomycin resistance and antibiotic overproduction.
AID424571	Antibacterial activity against stationary-phase rifampin-resistant Staphylococcus aureus 8325-4 culture assessed as number of viable colonies at 24 ug/ ml after 48 hrs	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID1738322	Antibacterial activity against mutidrug-resistant Staphylococcus aureus NRS100 assessed as reduction in bacterial growth incubated for 16 to 18 hrs by two fold serial dilution method	2020	European journal of medicinal chemistry, Jul-15, Volume: 198	Capsaicin derivatives with nitrothiophene substituents: Design, synthesis and antibacterial activity against multidrug-resistant S. aureus.
AID1132237	Antibacterial activity against drug-sensitive Salmonella 1287 assessed as growth inhibition by agar dilution method	1978	Journal of medicinal chemistry, Feb, Volume: 21, Issue:2	Chemical modification of 1,4-diamino-1,4-dideoxy-3-O-(4-deoxy-4-propionamido-alpha-D-glucopyranosyl)-D-glucitol.
AID544277	Antimicrobial activity against Enterococcus faecalis NKH7 harboring pMG2200-like plasmid after 24 hrs by agar dilution method	2009	Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2	Isolation of VanB-type Enterococcus faecalis strains from nosocomial infections: first report of the isolation and identification of the pheromone-responsive plasmids pMG2200, Encoding VanB-type vancomycin resistance and a Bac41-type bacteriocin, and pMG2
AID1565709	Antifungal activity against Candida albicans B-311 incubated for 24 to 36 hrs by two fold dilution method	2019	European journal of medicinal chemistry, Nov-15, Volume: 182	Scalable and cost-effective tosylation-mediated synthesis of antifungal and fungal diagnostic 6″-Modified amphiphilic kanamycins.
AID1478531	Antibacterial activity against aminoglycosides-resistant Escherichia coli BL21 harboring pETSACG1 encode for APH(3')-3a resistance enzyme by double microdilution method	2017	Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11	Covalently linked kanamycin - Ciprofloxacin hybrid antibiotics as a tool to fight bacterial resistance.
AID162730	Antibacterial activity expressed as MIC value was determined on Proteus mirabilis A-9900 organism	1986	Journal of medicinal chemistry, May, Volume: 29, Issue:5	Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin.
AID424577	Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH336 (SCV-8) harboring His438Asn mutation in fusA gene after 18 to 24 hrs by Etest strip assay	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID725075	Antimicrobial activity against Pseudomonas aeruginosa after 12 to 18 hrs by micro-well dilution method	2013	European journal of medicinal chemistry, Jan, Volume: 59	Synthesis and antibacterial and antifungal evaluation of some chalcone based sulfones and bisulfones.
AID575169	Inhibition of acrAB AcrAB-TolC-mediated Nile Red efflux in Escherichia coli K-12 3-AG100 overexpressing acrAB AcrAB-TolC assessed as time needed for 50% efflux after energization with 50 mM glucose at 1000 uM by spectrofluorometric assay	2010	Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9	Optimized Nile Red efflux assay of AcrAB-TolC multidrug efflux system shows competition between substrates.
AID544286	Antimicrobial activity against Enterococcus faecalis NKH16 harboring pMG2200-like plasmid after 24 hrs by agar dilution method	2009	Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2	Isolation of VanB-type Enterococcus faecalis strains from nosocomial infections: first report of the isolation and identification of the pheromone-responsive plasmids pMG2200, Encoding VanB-type vancomycin resistance and a Bac41-type bacteriocin, and pMG2
AID1225387	Antibacterial activity against Escherichia coli AG102 overexpressing AcrAB-TolC by p-iodonitrotetrazolium chloride colorimetric assay	2015	Journal of natural products, Mar-27, Volume: 78, Issue:3	Enhancement of antibiotic activity against multidrug-resistant bacteria by the efflux pump inhibitor 3,4-dibromopyrrole-2,5-dione isolated from a Pseudoalteromonas sp.
AID759044	Antibacterial activity against Escherichia coli assessed as survival after 24 hrs by MTT assay	2013	European journal of medicinal chemistry, Jul, Volume: 65	Potentiating 1-(2-hydroxypropyl)-2-styryl-5-nitroimidazole derivatives against antibacterial agents: design, synthesis and biology analysis.
AID532980	Antibacterial activity against Escherichia coli DH5alpha in presence of 10 mM N-Acetylcysteine	2010	Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8	N-acetylcysteine-mediated modulation of bacterial antibiotic susceptibility.
AID1629133	Binding affinity to 16S rRNA A-site in Escherichia coli S30 extract assessed as inhibition of translation measured after 30 mins by coupled transcription/translation-based luciferase reporter gene assay	2016	Journal of medicinal chemistry, 09-08, Volume: 59, Issue:17	Effects of 5-O-Ribosylation of Aminoglycosides on Antimicrobial Activity and Selective Perturbation of Bacterial Translation.
AID257550	Antibacterial activity against Streptococcus faecalis	2005	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 15, Issue:23	Synthesis and biological evaluation of novel (L)-alpha-amino acid methyl ester, heteroalkyl, and aryl substituted 1,4-naphthoquinone derivatives as antifungal and antibacterial agents.
AID1402049	Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 after 18 to 20 hrs by spectrophotometry based microdilution method	2018	European journal of medicinal chemistry, Jan-01, Volume: 143	Synthesis and antimicrobial activity of amino acid and peptide derivatives of mycophenolic acid.
AID1230064	Antibacterial activity against methicillin-resistant Staphylococcus aureus GRE2272 assessed as inhibition of bacterial growth	2015	Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13	Synthesis and antimicrobial activity of chloramphenicol-polyamine conjugates.
AID1287399	Antimicrobial activity against Enterobacter aerogenes after 24 hrs by serial two-fold microbroth dilution method	2016	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 26, Issue:6	One-pot synthesis and antimicrobial evaluation of novel 3-cyanopyridine derivatives of (-)-β-pinene.
AID569259	Antimycobacterial activity against Mycobacterium avium subsp. avium ATCC 2529I	2011	Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3	Synthesis and evaluation of anti-tubercular activity of new dithiocarbamate sugar derivatives.
AID1303895	Antibacterial activity against multidrug resistant Pseudomonas aeruginosa NCTC 10332 (ATCC 10145) assessed as reduction in bacterial growth incubated for 6 to 8 hrs	2016	Bioorganic & medicinal chemistry letters, 07-01, Volume: 26, Issue:13	GroEL/ES inhibitors as potential antibiotics.
AID749375	Antimicrobial activity against Staphylococcus aureus ATCC 6538 after 24 hrs by two fold serial dilution method	2013	Bioorganic & medicinal chemistry, Jun-01, Volume: 21, Issue:11	Design, synthesis and antimicrobial activities evaluation of Schiff base derived from secnidazole derivatives as potential FabH inhibitors.
AID293867	Antimicrobial activity against Pseudomonas aeruginosa ATCC 27853 after 24 hrs by two fold dilution method	2007	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6	Synthesis of pseudopeptides based L-tryptophan as a potential antimicrobial agent.
AID144139	Antibacterial activity against Mycobacterium intracellular.	1985	Journal of medicinal chemistry, Dec, Volume: 28, Issue:12	Synthesis and antibacterial activity of 2,2'-dithiobis(benzamide) derivatives against Mycobacterium species.
AID1402053	Antibacterial activity against ESBL positive Klebsiella pneumoniae ATCC 700603 after 18 to 20 hrs by spectrophotometry based microdilution method	2018	European journal of medicinal chemistry, Jan-01, Volume: 143	Synthesis and antimicrobial activity of amino acid and peptide derivatives of mycophenolic acid.
AID574810	Antimycobacterial activity against extensively drug-resistant Mycobacterium tuberculosis isolate 2911 horboring rpoB D516V, katG S315T/R463L, gyrA D94G/S95T/R128S/Y129C, rrs A1401G by CLSI method	2010	Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11	Emergence and molecular characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates from the Delhi Region in India.
AID381841	Antibacterial activity against Bacillus subtilis ATCC 6633	2008	Bioorganic & medicinal chemistry, Apr-01, Volume: 16, Issue:7	Synthesis, structure and antibacterial activity of novel 1-(5-substituted-3-substituted-4,5-dihydropyrazol-1-yl)ethanone oxime ester derivatives.
AID1585696	Antitubercular activity against Mycobacterium tuberculosis H37Rv by microplate alamar blue assay	2019	European journal of medicinal chemistry, Jan-15, Volume: 162	Fluoroquinolone-isatin hybrids and their biological activities.
AID1740923	Inhibition of human Cx43 expressed in Escherichia coli LB2003 cells in medium containing 8 mM K+ and 10 uM IPTG by measuring cell growth after 18 hrs by plate reader	2020	European journal of medicinal chemistry, Oct-01, Volume: 203	Amphiphilic aminoglycosides with increased selectivity for inhibition of connexin 43 (Cx43) hemichannels.
AID293869	Antimicrobial activity against Proteus vulgaris CMCC(B) 49001 after 24 hrs by two fold dilution method	2007	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6	Synthesis of pseudopeptides based L-tryptophan as a potential antimicrobial agent.
AID326547	Antimicrobial activity against Mycobacterium abscessus R65 isolate after 3 to 5 days by broth microdilution method	2007	Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5	In Vitro activities of isepamicin, other aminoglycosides, and capreomycin against clinical isolates of rapidly growing mycobacteria in Taiwan.
AID68015	Antibacterial activity expressed as MIC value was determined on Enterobacter cloacae A-20364 organism	1986	Journal of medicinal chemistry, May, Volume: 29, Issue:5	Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin.
AID1265789	Antibacterial activity against Staphylococcus aureus ATCC 29213 by microdilution method	2015	Journal of medicinal chemistry, Dec-10, Volume: 58, Issue:23	Synthesis and Bioactivities of Kanamycin B-Derived Cationic Amphiphiles.
AID1617944	Antibacterial activity against Escherichia coli ATCC 12435 after 16 to 48 hrs	2019	Journal of natural products, 12-27, Volume: 82, Issue:12	Structure Determination, Functional Characterization, and Biosynthetic Implications of Nybomycin Metabolites from a Mining Reclamation Site-Associated
AID1265782	Antibacterial activity against Klebsiella pneumoniae ATCC 27736 by microdilution method	2015	Journal of medicinal chemistry, Dec-10, Volume: 58, Issue:23	Synthesis and Bioactivities of Kanamycin B-Derived Cationic Amphiphiles.
AID1132234	Antibacterial activity against unpigmented Serratia 2840 assessed as growth inhibition by agar dilution method	1978	Journal of medicinal chemistry, Feb, Volume: 21, Issue:2	Chemical modification of 1,4-diamino-1,4-dideoxy-3-O-(4-deoxy-4-propionamido-alpha-D-glucopyranosyl)-D-glucitol.
AID278263	Antimicrobial activity against Salmonella enterica serovar Typhimurium CHS14 tolC::Kan with GyrA D87G mutant	2007	Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2	Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials.
AID544279	Antimicrobial activity against Enterococcus faecalis NKH9 harboring pMG2200-like and pMG2201-like plasmids after 24 hrs by agar dilution method	2009	Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2	Isolation of VanB-type Enterococcus faecalis strains from nosocomial infections: first report of the isolation and identification of the pheromone-responsive plasmids pMG2200, Encoding VanB-type vancomycin resistance and a Bac41-type bacteriocin, and pMG2
AID1265795	Antibacterial activity against vancomycin-resistant Enterococcus by microdilution method	2015	Journal of medicinal chemistry, Dec-10, Volume: 58, Issue:23	Synthesis and Bioactivities of Kanamycin B-Derived Cationic Amphiphiles.
AID1359446	Antibacterial activity against Bacillus subtilis NCIM 2079 after 12 hrs by serial dilution method	2018	European journal of medicinal chemistry, May-25, Volume: 152	Antibacterial and anti-TB tat-peptidomimetics with improved efficacy and half-life.
AID1132232	Antibacterial activity against drug-sensitive Klebsiella 2921 assessed as growth inhibition by agar dilution method	1978	Journal of medicinal chemistry, Feb, Volume: 21, Issue:2	Chemical modification of 1,4-diamino-1,4-dideoxy-3-O-(4-deoxy-4-propionamido-alpha-D-glucopyranosyl)-D-glucitol.
AID759042	Antibacterial activity against Bacillus thuringiensis assessed as survival after 24 hrs by MTT assay	2013	European journal of medicinal chemistry, Jul, Volume: 65	Potentiating 1-(2-hydroxypropyl)-2-styryl-5-nitroimidazole derivatives against antibacterial agents: design, synthesis and biology analysis.
AID530051	Antimicrobial activity against Staphylococcus aureus 286607-R1 harboring wild type gyrB by broth microdilution method	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Discovery and characterization of QPT-1, the progenitor of a new class of bacterial topoisomerase inhibitors.
AID1202745	Antimicrobial activity against Trichophyton mentagrophytes IFM62679 assessed as reduction in bacterial growth incubated for 48 hrs by microbroth dilution method	2015	Journal of natural products, Feb-27, Volume: 78, Issue:2	Prenylated benzophenones from Triadenum japonicum.
AID1866812	Antifungal activity against Bacillus subtilis assessed as reduction in microbial growth after 24 hrs by two-fold dilution method	2022	Journal of natural products, 04-22, Volume: 85, Issue:4	Secondary Metabolites from
AID424568	Antibacterial activity against fusidic acid-resistant Staphylococcus aureus AH209 harboring deletion of nucleotide 404-427 in rplF gene after 18 to 24 hrs by Etest strip assay	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID556561	Antimicrobial activity against sodB gene-deficient Escherichia coli K-12 DKsodB by broth dilution method	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	Contribution of oxidative damage to antimicrobial lethality.
AID534343	Antimicrobial activity against Burkholderia pseudomallei Bp173 harboring mini-Tn7T after 24 hrs by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8	The BpeAB-OprB efflux pump of Burkholderia pseudomallei 1026b does not play a role in quorum sensing, virulence factor production, or extrusion of aminoglycosides but is a broad-spectrum drug efflux system.
AID1473740	Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and GSH measured after 10 mins by membrane vesicle transport assay	2013	Toxicological sciences : an official journal of the Society of Toxicology, Nov, Volume: 136, Issue:1	A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
AID163261	Minimum inhibitory concentration was measured against Pseudomonas aeruginosa A 20357	1980	Journal of medicinal chemistry, Jan, Volume: 23, Issue:1	Aminoglycoside antibiotics. 3. Epimino derivatives of neamine, ribostamycin, and kanamycin B.
AID1167360	Antibacterial activity against wild type Staphylococcus epidermidis ATCC 35984 after 18 to 24 hrs by two-fold broth microdilution method	2014	Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21	Design, synthesis, and antibacterial properties of dual-ligand inhibitors of acetyl-CoA carboxylase.
AID524265	Antibacterial activity against Escherichia coli NKE159 harboring deletion mutation in acrB, cpxAR protein and plasmid expressing nlpE gene	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Effect of NlpE overproduction on multidrug resistance in Escherichia coli.
AID540928	Antimicrobial activity against streptomycin-resistant Streptomyces coelicolor KO-178 harboring rpsL K88E mutant gene after 48 hrs	2009	Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3	A novel insertion mutation in Streptomyces coelicolor ribosomal S12 protein results in paromomycin resistance and antibiotic overproduction.
AID524266	Antibacterial activity against Escherichia coli NKE128 harboring deletion mutation in acrB and tolC protein	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Effect of NlpE overproduction on multidrug resistance in Escherichia coli.
AID278245	Antimicrobial activity against Salmonella enterica serovar Typhimurium S21-4 gyrA+ with ParC S80I mutation	2007	Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2	Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials.
AID532984	Antibacterial activity against Escherichia coli MG1655 in presence of 10 mM N-Acetylcysteine	2010	Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8	N-acetylcysteine-mediated modulation of bacterial antibiotic susceptibility.
AID1710565	Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 1960649 assessed as reduction in bacterial growth incubated for 15 to 20 hrs by broth microdilution method	2018	MedChemComm, Jul-01, Volume: 9, Issue:7	Targeting miRNA by tunable small molecule binders: peptidic aminosugar mediated interference in miR-21 biogenesis reverts epithelial to mesenchymal transition.
AID1056538	Antibacterial activity against Aeromonas hydrophila ATCC 7966 by broth microdilution method	2013	Journal of natural products, Dec-27, Volume: 76, Issue:12	Cytotoxic and antibacterial marfuraquinocins from the deep South China Sea-derived Streptomyces niveus SCSIO 3406.
AID551744	Antibacterial activity against Mycobacterium smegmatis ATCC 14468 after 12 to 18 hrs by twofold dilution method	2011	Bioorganic & medicinal chemistry, Jan-01, Volume: 19, Issue:1	Synthesis and antibacterial activity study of a novel class of cationic anthraquinone analogs.
AID342023	Antibacterial activity against Escherichia coli J53 by broth microdilution test	2007	Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8	Sequencing and comparative genomic analysis of pK29, a 269-kilobase conjugative plasmid encoding CMY-8 and CTX-M-3 beta-lactamases in Klebsiella pneumoniae.
AID207040	Antibacterial activity expressed as MIC value was determined on Staphylococcus aureus A-22058 organism	1986	Journal of medicinal chemistry, May, Volume: 29, Issue:5	Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin.
AID1478535	Ratio of MIC for Escherichia coli XL1 blue harboring pET9d encode for APH(3')-1a resistance enzyme to MIC for Escherichia coli XL1 blue	2017	Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11	Covalently linked kanamycin - Ciprofloxacin hybrid antibiotics as a tool to fight bacterial resistance.
AID424576	Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH334 (SCV-6) harboring Thr436Ile mutation in fusA gene after 18 to 24 hrs by Etest strip assay	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID1079946	Presence of at least one case with successful reintroduction. [column 'REINT' in source]
AID278560	Antimicrobial activity against 90 mins hydrogen peroxide-stressed Bifidobacterium bifidum BB12 after 18 hrs	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID381178	Antibacterial activity against Pseudomonas aeruginosa after 24 to 72 hrs by disk diffusion method	1999	Journal of natural products, Sep, Volume: 62, Issue:9	Antimicrobial and antitumor activities of mycosporulone.
AID750183	Antibacterial activity against Bacillus subtilis ATCC 6633 assessed as growth inhibition after 24 hrs by two-fold serial dilution method	2013	European journal of medicinal chemistry, Jun, Volume: 64	Synthesis and antimicrobical evaluation of a novel class of 1,3,4-thiadiazole: derivatives bearing 1,2,4-triazolo[1,5-a]pyrimidine moiety.
AID560250	Antibacterial activity against Staphylococcus aureus RN4220 harboring aadD and tet(L) gene by CLSI method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Novel ABC transporter gene, vga(C), located on a multiresistance plasmid from a porcine methicillin-resistant Staphylococcus aureus ST398 strain.
AID1565710	Antifungal activity against Candida rugosa 95-967 incubated for 24 to 36 hrs by two fold dilution method	2019	European journal of medicinal chemistry, Nov-15, Volume: 182	Scalable and cost-effective tosylation-mediated synthesis of antifungal and fungal diagnostic 6″-Modified amphiphilic kanamycins.
AID574797	Antimycobacterial activity against extensively drug-resistant Mycobacterium tuberculosis isolate 2911 obtained from sputum of patient at 4 ug/ml by Bactec MGIT960 modified proportion method	2010	Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11	Emergence and molecular characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates from the Delhi Region in India.
AID574811	Antimycobacterial activity against extensively drug-resistant Mycobacterium tuberculosis H37Rv by CLSI method	2010	Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11	Emergence and molecular characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates from the Delhi Region in India.
AID556756	Bactericidal activity against ahpC gene-deficient Escherichia coli K-12 3200 after 18 hrs	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	Contribution of oxidative damage to antimicrobial lethality.
AID283547	Antibacterial activity against Pseudomonas aeruginosa FE60 containing inactivated mexXY gene by microdilution method	2007	Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3	Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides.
AID424879	Antimicrobial activity against multidrug-resistant Enterobacter cloacae E705 bearing qnrB10 gene with aac(6)-IId-aadA1a integron in presence of IPTG	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Complex class 1 integrons with diverse variable regions, including aac(6')-Ib-cr, and a novel allele, qnrB10, associated with ISCR1 in clinical enterobacterial isolates from Argentina.
AID771496	Antibacterial activity against Acinetobacter baumannii by dilution technique	2013	European journal of medicinal chemistry, Oct, Volume: 68	Synthesis and biological evaluation of novel ocotillol-type triterpenoid derivatives as antibacterial agents.
AID1562313	Antimycobacterial activity against Mycobacterium smegmatis atR17 assessed as decrease in drug resistance development at 5 ug/disc after 2 to 3 days by paper disc method	2019	European journal of medicinal chemistry, Sep-15, Volume: 178	Synthesis and antimycobacterial activity of imidazo[1,2-b][1,2,4,5]tetrazines.
AID1348088	Antimicrobial activity against Pseudomonas aeruginosa ATCC 27853 assessed as zone of inhibition at 50 ug per disc after 24 hrs by disc diffusion assay	2018	European journal of medicinal chemistry, Jan-01, Volume: 143	Synthesis of new 1-benzyl tetrahydropyridinylidene ammonium salts and their antimicrobial and anticellular activities.
AID326548	Antimicrobial activity against Mycobacterium abscessus R53 isolate after 3 to 5 days by broth microdilution method	2007	Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5	In Vitro activities of isepamicin, other aminoglycosides, and capreomycin against clinical isolates of rapidly growing mycobacteria in Taiwan.
AID582764	Antimicrobial activity against eaeA negative verocytotoxin-producing non-O157 Escherichia coli isolates obtained from human assessed as percentage of resistant isolates	2010	Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11	Antimicrobial resistance testing of verocytotoxin-producing Escherichia coli and first description of TEM-52 extended-spectrum β-lactamase in serogroup O26.
AID278254	Antimicrobial activity against Salmonella enterica serovar Typhimurium CS3 acrAB::Kan with GyrA S83F, D87N, ParC S80I mutation	2007	Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2	Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials.
AID1105382	Antibacterial activity against Xanthomonas oryzae ITCC B-47 assessed as as growth inhibition at 25 ug/disk after 24 hr by disk diffusion method	2013	European journal of medicinal chemistry, Jan, Volume: 59	Microwave synthesis, characterization and bio-efficacy evaluation of novel chalcone based 6-carbethoxy-2-cyclohexen-1-one and 2H-indazol-3-ol derivatives.
AID381842	Antibacterial activity against Escherichia coli ATCC 35218	2008	Bioorganic & medicinal chemistry, Apr-01, Volume: 16, Issue:7	Synthesis, structure and antibacterial activity of novel 1-(5-substituted-3-substituted-4,5-dihydropyrazol-1-yl)ethanone oxime ester derivatives.
AID670725	Antibacterial activity against Staphylococcus aureus ATCC 25923 after 24 hrs by MTT assay	2012	Bioorganic & medicinal chemistry, Jul-15, Volume: 20, Issue:14	Design, synthesis and antimicrobial activities of nitroimidazole derivatives containing 1,3,4-oxadiazole scaffold as FabH inhibitors.
AID521594	Antibacterial activity against Salmonella enterica serovars virchow isolate 101591 at pH 5.7 by bioluminescence assay	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	Aminoglycosides affect intracellular Salmonella enterica serovars typhimurium and virchow.
AID1332980	Antitubercular activity against Mycobacterium tuberculosis H37Rv	2016	European journal of medicinal chemistry, Nov-10, Volume: 123	Synthesis and biological activity of furoxan derivatives against Mycobacterium tuberculosis.
AID524262	Antibacterial activity against Escherichia coli NKE155 harboring deletion mutation in acrB protein and plasmid expressing nlpE gene	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Effect of NlpE overproduction on multidrug resistance in Escherichia coli.
AID740233	Antibacterial activity against Staphylococcus aureus ATCC 530 assessed as growth inhibition after 24 hrs by MTT assay	2013	Bioorganic & medicinal chemistry, Apr-15, Volume: 21, Issue:8	Novel 1,3,4-oxadiazole thioether derivatives targeting thymidylate synthase as dual anticancer/antimicrobial agents.
AID523397	Antimicrobial activity against amikacin-susceptible Nocardia farcinica IFM 10152 harboring 16s rRNA A1408G mutant after 3 days by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6	Homozygous triplicate mutations in three 16S rRNA genes responsible for high-level aminoglycoside resistance in Nocardia farcinica clinical isolates from a Canada-wide bovine mastitis epizootic.
AID1263043	Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 at 1 mM after 24 to 48 hrs by Kirby-Bauer disc diffusion susceptibility test	2015	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 25, Issue:24	Synthesis and biological evaluation of pyrazolopyrimidines as potential antibacterial agents.
AID1624154	Antitubercular activity against multidrug-resistant Mycobacterium tuberculosis isolate 6 after 7 days	2019	European journal of medicinal chemistry, Feb-15, Volume: 164	Synthesis and evaluation of α-aminoacyl amides as antitubercular agents effective on drug resistant tuberculosis.
AID424603	Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH360 (SCV-32) harboring ATA start codon at nucleotide 3 in rplF gene after 18 to 24 hrs by Etest strip assay	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID584122	Antimicrobial activity against Staphylococcus aureus RN4220 by CLSI M31-A3 method	2011	Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1	Novel apramycin resistance gene apmA in bovine and porcine methicillin-resistant Staphylococcus aureus ST398 isolates.
AID1593371	Inhibition of Pks13 D1644G/N1640K double mutant thioesterase domain in Mycobacterium tuberculosis H37Rv assessed as reduction in bacterial growth by microplate alamar blue assay	2019	Journal of medicinal chemistry, 04-11, Volume: 62, Issue:7	Identification of Novel Coumestan Derivatives as Polyketide Synthase 13 Inhibitors against Mycobacterium tuberculosis. Part II.
AID625924	Antibacterial activity against Klebsiella pneumoniae ATCC 27736 by micro-broth dilution method	2011	Bioorganic & medicinal chemistry letters, Nov-01, Volume: 21, Issue:21	Micelles catalyzed chemoselective synthesis 'in water' and biological evaluation of oxygen containing hetero-1,4-naphthoquinones as potential antifungal agents.
AID530052	Antimicrobial activity against Staphylococcus aureus RN4220 expressing gyrB D437N mutant gene by broth microdilution method	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Discovery and characterization of QPT-1, the progenitor of a new class of bacterial topoisomerase inhibitors.
AID424341	Antibacterial activity against fusidic acid-resistant Staphylococcus aureus AH197 harboring Leu456Phe mutation in fusA gene after 18 to 24 hrs by Etest strip assay	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID556567	Antimicrobial activity against katG,katE gene-deficient Escherichia coli K-12 3201 by broth dilution method	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	Contribution of oxidative damage to antimicrobial lethality.
AID1348082	Antimicrobial activity against Candida tropicalis ATCC 13803 assessed as zone of inhibition at 50 ug per disc after 48 hrs by disc diffusion assay	2018	European journal of medicinal chemistry, Jan-01, Volume: 143	Synthesis of new 1-benzyl tetrahydropyridinylidene ammonium salts and their antimicrobial and anticellular activities.
AID405082	Antimicrobial activity against Escherichia coli 33587-TC9 by agar dilution method	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	Biochemical characterization of PER-2 and genetic environment of blaPER-2.
AID283656	Increase in ROS levels in Escherichia coli K12 MG1655 assessed as ratio of ROS with antibiotic to ROS without antibiotic	2007	Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3	Effects of glutathione and ascorbic acid on streptomycin sensitivity of Escherichia coli.
AID278533	Antimicrobial activity against Bifidobacterium breve R0070	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID278530	Antimicrobial activity against Bifidobacterium longum P/N 601377	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID1629122	Antimicrobial activity against Pseudomonas aeruginosa ATCC 47085 measured after 24 hrs by double-dilution method	2016	Journal of medicinal chemistry, 09-08, Volume: 59, Issue:17	Effects of 5-O-Ribosylation of Aminoglycosides on Antimicrobial Activity and Selective Perturbation of Bacterial Translation.
AID404901	Antibacterial activity against high-level gentamicin resistant Streptococcus pasteurianus SB41 isolate carrying transposon-borne resistance gene [aac(6')Ie-aph(2'')Ia] by agar dilution method	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	High-level gentamicin resistance mediated by a Tn4001-like transposon in seven nonclonal hospital isolates of Streptococcus pasteurianus.
AID1730995	Antitubercular activity against extensively drug resistance Mycobacterium tuberculosis R506 XDR by MABA	2021	European journal of medicinal chemistry, Mar-05, Volume: 213	Design and synthesis of mycobacterial pks13 inhibitors: Conformationally rigid tetracyclic molecules.
AID299661	Antibacterial activity against methicillin-susceptible Staphylococcus aureus ATCC 25923 by broth microdilution method	2007	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 17, Issue:15	Synthesis and evaluation of amphiphilic cationic quinine-derived for antibacterial activity against methicillin-resistant Staphylococcus aureus.
AID1695860	Antibacterial activity against Micrococcus Luteus ATCC 398 incubated for 24 hrs	2019	European journal of medicinal chemistry, Apr-15, Volume: 168	Comprehensive review on the anti-bacterial activity of 1,2,3-triazole hybrids.
AID551747	Antibacterial activity against Klebsiella pneumoniae ATCC 13883 after 12 to 18 hrs by twofold dilution method	2011	Bioorganic & medicinal chemistry, Jan-01, Volume: 19, Issue:1	Synthesis and antibacterial activity study of a novel class of cationic anthraquinone analogs.
AID563505	Antimicrobial activity against cetylpyridinium chloride-resistant Serratia marcescens 01 harboring plasmid STV29 by broth dilution method	2009	Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12	Mutational upregulation of a resistance-nodulation-cell division-type multidrug efflux pump, SdeAB, upon exposure to a biocide, cetylpyridinium chloride, and antibiotic resistance in Serratia marcescens.
AID1077161	Inhibition of Pseudomonas aeruginosa FabH after 25 mins	2014	European journal of medicinal chemistry, Apr-09, Volume: 76	Design and synthesis of 2-styryl of 5-Nitroimidazole derivatives and antimicrobial activities as FabH inhibitors.
AID285338	Antimicrobial activity against streptomycin-resistant Escherichia coli J53 transconjugant with qnrA1 producing urinary specimen isolate 13.52 by agar dilution method	2007	Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4	First report of plasmid-mediated qnrA1 in a ciprofloxacin-resistant Escherichia coli strain in Latin America.
AID551746	Antibacterial activity against Staphylococcus aureus ATCC 25923 after 12 to 18 hrs by twofold dilution method	2011	Bioorganic & medicinal chemistry, Jan-01, Volume: 19, Issue:1	Synthesis and antibacterial activity study of a novel class of cationic anthraquinone analogs.
AID486970	Antibacterial activity against Staphylococcus aureus ATCC 25923 after 24 hrs by micro broth dilution method	2010	European journal of medicinal chemistry, Jun, Volume: 45, Issue:6	'On water' assisted synthesis and biological evaluation of nitrogen and sulfur containing hetero-1,4-naphthoquinones as potent antifungal and antibacterial agents.
AID278559	Antimicrobial activity against 90 mins hydrogen peroxide-stressed Bifidobacterium bifidum R0071 after 18 hrs	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID625923	Antibacterial activity against Staphylococcus aureus ATCC 25923 by micro-broth dilution method	2011	Bioorganic & medicinal chemistry letters, Nov-01, Volume: 21, Issue:21	Micelles catalyzed chemoselective synthesis 'in water' and biological evaluation of oxygen containing hetero-1,4-naphthoquinones as potential antifungal agents.
AID424580	Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH332 (SCV-4) harboring Ala655Glu mutation in fusA gene after 18 to 24 hrs by Etest strip assay	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID460285	Antibacterial activity against aminoglycoside-susceptible Escherichia coli ATCC 25922 after 12 to 18 hrs	2010	Bioorganic & medicinal chemistry, Feb-15, Volume: 18, Issue:4	Synthesis of novel aminoglycosides via allylic azide rearrangement for investigating the significance of 2'-amino group.
AID404899	Antibacterial activity against high-level gentamicin resistant Streptococcus pasteurianus SB34 isolate carrying transposon-borne resistance gene [aac(6')Ie-aph(2'')Ia] by agar dilution method	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	High-level gentamicin resistance mediated by a Tn4001-like transposon in seven nonclonal hospital isolates of Streptococcus pasteurianus.
AID278269	Antimicrobial activity against Salmonella enterica serovar Typhimurium CHS38 gyrA+ with GyrA D87G mutation	2007	Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2	Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials.
AID158615	IC50 was measured as concentration causing 50% inhibition of lysosomal phospholipase A1 activity.	1995	Journal of medicinal chemistry, Nov-10, Volume: 38, Issue:23	Synthesis and antimicrobial and toxicological studies of amino acid and peptide derivatives of kanamycin A and netilmicin.
AID574791	Antimycobacterial activity against extensively drug-resistant Mycobacterium tuberculosis isolate 2301 obtained from sputum of patient at 4 ug/ml by Bactec MGIT960 modified proportion method	2010	Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11	Emergence and molecular characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates from the Delhi Region in India.
AID573966	Antibacterial activity against Cj1211-positive Campylobacter jejuni harboring aphA3 and tet(O) genes	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Role of Cj1211 in natural transformation and transfer of antibiotic resistance determinants in Campylobacter jejuni.
AID283538	Antibacterial activity against Pseudomonas aeruginosa FE53G with inactivated mexZ and nuoG genes by microdilution method	2007	Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3	Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides.
AID1905609	Induction of drug resistance in Escherichia coli ATCC 25922 assessed as increase in MIC measured after 20 passages by CLSI protocol based broth microdilution method	2022	Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7	Novel β-Hairpin Antimicrobial Peptides Containing the β-Turn Sequence of -RRRF- Having High Cell Selectivity and Low Incidence of Drug Resistance.
AID283542	Antibacterial activity against Pseudomonas aeruginosa FE57GU with inactivated rplY, nuoG and galU genes by microdilution method	2007	Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3	Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides.
AID102513	In vitro inhibition of translation in luciferase SP6 control plasmid	2002	Journal of medicinal chemistry, Aug-01, Volume: 45, Issue:16	New inhibitors of bacterial protein synthesis from a combinatorial library of macrocycles.
AID574808	Antimycobacterial activity against extensively drug-resistant Mycobacterium tuberculosis isolate 2301 horboring rpoB S531L, katG R463L/E217G, gyrA D94N/S95T, rrs A1401G by CLSI method	2010	Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11	Emergence and molecular characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates from the Delhi Region in India.
AID1413323	Antibacterial activity against Micrococcus luteus ATCC 10240	2018	MedChemComm, Jun-01, Volume: 9, Issue:6	Antifungal amphiphilic kanamycins: new life for an old drug.
AID283646	Susceptibility of Escherichia coli K12 MG1655 by agar dilution method	2007	Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3	Effects of glutathione and ascorbic acid on streptomycin sensitivity of Escherichia coli.
AID1731000	Antibacterial activity against Escherichia coli AB1157 assessed as inhibition of bacterial growth measured after 18 hrs by two fold serial dilution method	2021	European journal of medicinal chemistry, Mar-05, Volume: 213	Design and synthesis of mycobacterial pks13 inhibitors: Conformationally rigid tetracyclic molecules.
AID1905564	Antimicrobial activity against Enterococcus faecalis ATCC 29212 assessed as reduction of bacterial growth incubated for 18 hrs by CLSI protocol based broth microdilution method	2022	Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7	Novel β-Hairpin Antimicrobial Peptides Containing the β-Turn Sequence of -RRRF- Having High Cell Selectivity and Low Incidence of Drug Resistance.
AID1167359	Antibacterial activity against Staphylococcus aureus ATCC 29213 expressing norA after 18 to 24 hrs by two-fold broth microdilution method	2014	Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21	Design, synthesis, and antibacterial properties of dual-ligand inhibitors of acetyl-CoA carboxylase.
AID1359444	Antibacterial activity against Pseudomonas aeruginosa NCIM 2036 after 8 hrs by serial dilution method	2018	European journal of medicinal chemistry, May-25, Volume: 152	Antibacterial and anti-TB tat-peptidomimetics with improved efficacy and half-life.
AID206394	Compound was tested for photoinhibition of Staphylococcus aureus(CIP 53156); Sensitive	1998	Bioorganic & medicinal chemistry letters, Nov-03, Volume: 8, Issue:21	Nitroglycosylated meso-arylporphyrins as photoinhibitors of gram positive bacteria.
AID1348085	Antimicrobial activity against Klebsiella oxytoca ATCC 8724 assessed as zone of inhibition at 50 ug per disc after 24 hrs by disc diffusion assay	2018	European journal of medicinal chemistry, Jan-01, Volume: 143	Synthesis of new 1-benzyl tetrahydropyridinylidene ammonium salts and their antimicrobial and anticellular activities.
AID625282	Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cirrhosis	2011	PLoS computational biology, Dec, Volume: 7, Issue:12	Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID1077167	Antibacterial activity against Bacillus thuringiensis after 12 hrs by MTT assay	2014	European journal of medicinal chemistry, Apr-09, Volume: 76	Design and synthesis of 2-styryl of 5-Nitroimidazole derivatives and antimicrobial activities as FabH inhibitors.
AID381181	Antibacterial activity against Streptococcus faecalis after 24 to 72 hrs by disk diffusion method	1999	Journal of natural products, Sep, Volume: 62, Issue:9	Antimicrobial and antitumor activities of mycosporulone.
AID524261	Antibacterial activity against Escherichia coli NKE154 harboring vector expressing acrB deletion mutant	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Effect of NlpE overproduction on multidrug resistance in Escherichia coli.
AID1866814	Antifungal activity against Staphylococcus aureus assessed as reduction in microbial growth after 24 hrs by two-fold dilution method	2022	Journal of natural products, 04-22, Volume: 85, Issue:4	Secondary Metabolites from
AID625278	FDA Liver Toxicity Knowledge Base Benchmark Dataset (LTKB-BD) drugs of no concern for DILI	2011	Drug discovery today, Aug, Volume: 16, Issue:15-16	FDA-approved drug labeling for the study of drug-induced liver injury.
AID283549	Antibacterial activity against Pseudomonas aeruginosa FE64 containing inactivated rplY and mexXY genes by microdilution method	2007	Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3	Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides.
AID278527	Antimicrobial activity against Bifidobacterium longum ATCC 15707	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID521597	Antibacterial activity against Salmonella enterica serovars Typhimurium ATCC 14028 at pH 5.7 by bioluminescence assay	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	Aminoglycosides affect intracellular Salmonella enterica serovars typhimurium and virchow.
AID1271383	Antimicrobial activity against Gram-negative Haemophilus influenzae ATCC 51907 after 16 to 24 hrs by micro-dilution method	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Synthesis and Biological Activity of Mono- and Di-N-acylated Aminoglycosides.
AID424824	Antibacterial activity against kanamycin-resistant and fusidic acid-susceptible Staphylococcus aureus AH296 harboring Gly664Ala mutation in fusA gene after 18 to 24 hrs by Etest strip assay	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID1624149	Antitubercular activity against isoniazid/ethionamide resistant Mycobacterium tuberculosis isolate 1 after 7 days	2019	European journal of medicinal chemistry, Feb-15, Volume: 164	Synthesis and evaluation of α-aminoacyl amides as antitubercular agents effective on drug resistant tuberculosis.
AID1585462	Antibacterial activity against oxacillin/tetracycline-resistant Staphylococcus aureus NRS-100 measured after 16 hrs	2019	European journal of medicinal chemistry, Jan-15, Volume: 162	Design, synthesis and evaluation of hybrid of tetrahydrocarbazole with 2,4-diaminopyrimidine scaffold as antibacterial agents.
AID1869559	Antibacterial activity against Mycobacterium phlei DSM 43239 assessed as reduction in bacterial growth measured after 3 days by broth microdilution method	2022	Journal of natural products, 06-24, Volume: 85, Issue:6	Triculamin: An Unusual Lasso Peptide with Potent Antimycobacterial Activity.
AID290145	Antibacterial activity against Escherichia coli after 24 hrs by MTT colorimetric method	2007	European journal of medicinal chemistry, Apr, Volume: 42, Issue:4	Synthesis and antimicrobial activities of Schiff bases derived from 5-chloro-salicylaldehyde.
AID563502	Antimicrobial activity against cetylpyridinium chloride-sensitive Serratia marcescens 71 by broth dilution method	2009	Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12	Mutational upregulation of a resistance-nodulation-cell division-type multidrug efflux pump, SdeAB, upon exposure to a biocide, cetylpyridinium chloride, and antibiotic resistance in Serratia marcescens.
AID1182141	Antitubercular activity against Mycobacterium smegmatis by checkerboard assay in presence of chlorpromazine-N-oxide	2014	Bioorganic & medicinal chemistry, Aug-15, Volume: 22, Issue:16	Pharmacologically active metabolites, combination screening and target identification-driven drug repositioning in antituberculosis drug discovery.
AID278536	Antimicrobial activity against 60 min 1 M HCl-stressed Bifidobacterium bifidum BB12 after 18 hrs	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID1765575	Antibacterial activity against Enterococcus faecalis ATCC 29212 incubated for 18 hrs by CLSI based broth dilution method	2021	Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15	Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID535770	Antimicrobial activity against Mycobacterium ulcerans Cu001 agar dilution method	2010	Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7	Rapid assessment of antibacterial activity against Mycobacterium ulcerans by using recombinant luminescent strains.
AID1079947	Comments (NB not yet translated). [column 'COMMENTAIRES' in source]
AID278233	Antimicrobial activity against Salmonella enterica serovar Typhimurium S21-1 gyrA+	2007	Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2	Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials.
AID544284	Antimicrobial activity against Enterococcus faecalis NKH14 harboring pMG2200-like and pMG2201-like plasmids after 24 hrs by agar dilution method	2009	Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2	Isolation of VanB-type Enterococcus faecalis strains from nosocomial infections: first report of the isolation and identification of the pheromone-responsive plasmids pMG2200, Encoding VanB-type vancomycin resistance and a Bac41-type bacteriocin, and pMG2
AID510750	Antibacterial activity against Escherichia coli AG102MB harboring pS1328-based acrB gene	2010	Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3	Single nucleotide polymorphism analysis of the major tripartite multidrug efflux pump of Escherichia coli: functional conservation in disparate animal reservoirs despite exposure to antimicrobial chemotherapy.
AID278545	Antimicrobial activity against 90 mins oxgall-stressed Bifidobacterium animalis ATCC 27536 after 18 hrs	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID1182138	Antitubercular activity against Mycobacterium smegmatis assessed as reduction in MIC99 by checkerboard assay in presence of chlorpromazine-N-S-dioxide relative to control	2014	Bioorganic & medicinal chemistry, Aug-15, Volume: 22, Issue:16	Pharmacologically active metabolites, combination screening and target identification-driven drug repositioning in antituberculosis drug discovery.
AID1594068	Antibacterial activity against Escherichia coli assessed as reduction in bacterial cell viability incubated for 20 to 24 hrs by REMA method	2019	Bioorganic & medicinal chemistry, 06-15, Volume: 27, Issue:12	Design, synthesis, in-silico studies and biological screening of quinazolinone analogues as potential antibacterial agents against MRSA.
AID718272	Antimicrobial activity against Bacillus thuringiensis	2012	Journal of natural products, Dec-28, Volume: 75, Issue:12	Marthiapeptide A, an anti-infective and cytotoxic polythiazole cyclopeptide from a 60 L scale fermentation of the deep sea-derived Marinactinospora thermotolerans SCSIO 00652.
AID325448	Antibacterial activity against Staphylococcus aureus Mu50 after 14 to 16 hrs by broth dilution method	2007	Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6	Polyamine effects on antibiotic susceptibility in bacteria.
AID532027	Antimicrobial activity against Kluyvera georgiana 14751 expressing beta-lactamase CTX-M-78 obtained from bloodstream of patient by disk diffusion method	2010	Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7	Novel chromosome-encoded CTX-M-78 beta-lactamase from a Kluyvera georgiana clinical isolate as a putative origin of CTX-M-25 subgroup.
AID524391	Antibacterial activity against Escherichia coli NKE1368 harboring deletion mutation in acrB, acrD and vector expressing mdtABC gene	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Effect of NlpE overproduction on multidrug resistance in Escherichia coli.
AID1230065	Antibacterial activity against methicillin-resistant Staphylococcus aureus GRE2372 assessed as inhibition of bacterial growth	2015	Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13	Synthesis and antimicrobial activity of chloramphenicol-polyamine conjugates.
AID424593	Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH379 (SCV-51) harboring TAA stop codon at nucleotide 418 in rplF but gene after 18 to 24 hrs by Etest strip assay	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID556590	Bactericidal activity against sodB gene-deficient Escherichia coli K-12 DK after 18 hrs	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	Contribution of oxidative damage to antimicrobial lethality.
AID1905567	Antimicrobial activity against Pseudomonas aeruginosa ATCC 27853 assessed as reduction of bacterial growth incubated for 18 hrs by CLSI protocol based broth microdilution method	2022	Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7	Novel β-Hairpin Antimicrobial Peptides Containing the β-Turn Sequence of -RRRF- Having High Cell Selectivity and Low Incidence of Drug Resistance.
AID501184	Antimicrobial activity against Candida albicans 54 at 30 ug after 18 hrs by agar diffusion method	2009	Journal of natural products, Oct, Volume: 72, Issue:10	Norselic acids A-E, highly oxidized anti-infective steroids that deter mesograzer predation, from the Antarctic sponge Crella sp.
AID1262358	Antibacterial activity against clinical isolates Escherichia coli after 24 hrs by agar diffusion assay	2015	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 25, Issue:24	PPL catalyzed four-component PASE synthesis of 5-monosubstituted barbiturates: Structure and pharmacological properties.
AID774293	Cytotoxicity against african green monkey Vero cells after 72 hrs by MTS-PMS assay	2013	Journal of natural products, Oct-25, Volume: 76, Issue:10	Chlorinated coumarins from the polypore mushroom Fomitopsis officinalis and their activity against Mycobacterium tuberculosis.
AID1565711	Antifungal activity against azole-resistant Candida parapsilosis Cas08-0490 incubated for 24 to 36 hrs by two fold dilution method	2019	European journal of medicinal chemistry, Nov-15, Volume: 182	Scalable and cost-effective tosylation-mediated synthesis of antifungal and fungal diagnostic 6″-Modified amphiphilic kanamycins.
AID1868106	Antibacterial activity against methicillin-resistant Staphylococcus aureus clinical isolate 9B assessed as inhibition of visible bacterial growth incubated for 18 hrs by CLSI protocol based assay	2022	Journal of natural products, 05-27, Volume: 85, Issue:5	Enceleamycins A-C, Furo-Naphthoquinones from
AID1629135	Selectivity ratio, ratio of IC50 for cytosolic eukaryotic translation in rabbit reticulocyte S30 extract to IC50 for 16S rRNA A-site in Escherichia coli S30 extract	2016	Journal of medicinal chemistry, 09-08, Volume: 59, Issue:17	Effects of 5-O-Ribosylation of Aminoglycosides on Antimicrobial Activity and Selective Perturbation of Bacterial Translation.
AID1167358	Antibacterial activity against moiramide-resistant Staphylococcus aureus ATCC 29213 after 18 to 24 hrs by two-fold broth microdilution method	2014	Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21	Design, synthesis, and antibacterial properties of dual-ligand inhibitors of acetyl-CoA carboxylase.
AID1869575	Antibacterial activity against Enterobacter cloacae DSM 30054 assessed as reduction in bacterial growth measured after 3 days by broth microdilution method	2022	Journal of natural products, 06-24, Volume: 85, Issue:6	Triculamin: An Unusual Lasso Peptide with Potent Antimycobacterial Activity.
AID285337	Antimicrobial activity against Escherichia coli qnrA1 producing urinary specimen isolate 13.52 by agar dilution method	2007	Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4	First report of plasmid-mediated qnrA1 in a ciprofloxacin-resistant Escherichia coli strain in Latin America.
AID1478540	Resistance index, ratio of MIC for Bacillus subtilis ATCC 6633 in 15th subculture to MIC for Bacillus subtilis ATCC 6633 in first subculture	2017	Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11	Covalently linked kanamycin - Ciprofloxacin hybrid antibiotics as a tool to fight bacterial resistance.
AID683685	Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 after 7 days by microplate alamar blue assay	2012	European journal of medicinal chemistry, Nov, Volume: 57	The design, synthesis, in silico ADME profiling, antiplasmodial and antimycobacterial evaluation of new arylamino quinoline derivatives.
AID69755	Antibacterial activity expressed as MIC value was determined on Escherichia coli A-22045 organism	1986	Journal of medicinal chemistry, May, Volume: 29, Issue:5	Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin.
AID524386	Antibacterial activity against Escherichia coli NKE157 harboring deletion mutation in acrB, acrD protein and plasmid expressing nlpE gene	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Effect of NlpE overproduction on multidrug resistance in Escherichia coli.
AID540210	Clearance in human after iv administration	2008	Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7	Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
AID560591	Antimicrobial activity against Pseudomonas aeruginosa isolate IMCJ799 by microdilution method	2009	Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6	AAC(6')-Iaf, a novel aminoglycoside 6'-N-acetyltransferase from multidrug-resistant Pseudomonas aeruginosa clinical isolates.
AID424586	Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH352 (SCV-24) harboring -1 frameshift mutation at nucleotide 106 in rplF gene after 18 to 24 hrs by Etest strip assay	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID424579	Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH340 (SCV-12) harboring Gly617Asp mutation in fusA gene after 18 to 24 hrs by Etest strip assay	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID126452	Dissociation constant for binding to mitochondrial 12S rRNA construct M5 was determined	2002	Bioorganic & medicinal chemistry letters, Aug-19, Volume: 12, Issue:16	Decoding region bubble size and aminoglycoside antibiotic binding.
AID740236	Antibacterial activity against Escherichia coli ATCC 25922 assessed as growth inhibition after 24 hrs by MTT assay	2013	Bioorganic & medicinal chemistry, Apr-15, Volume: 21, Issue:8	Novel 1,3,4-oxadiazole thioether derivatives targeting thymidylate synthase as dual anticancer/antimicrobial agents.
AID1079938	Chronic liver disease either proven histopathologically, or through a chonic elevation of serum amino-transferase activity after 6 months. Value is number of references indexed. [column 'CHRON' in source]
AID278524	Antimicrobial activity against Bifidobacterium bifidum BB12	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID565229	Antimicrobial activity against Mycobacterium chelonae ATCC 35752 harboring pZS01 carrying mspA gene by resazurine microtiter assay	2009	Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9	Role of porins in the susceptibility of Mycobacterium smegmatis and Mycobacterium chelonae to aldehyde-based disinfectants and drugs.
AID534345	Antimicrobial activity against Burkholderia pseudomallei Bp175 harboring mini-Tn7T-P1-bpeR+ after 24 hrs by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8	The BpeAB-OprB efflux pump of Burkholderia pseudomallei 1026b does not play a role in quorum sensing, virulence factor production, or extrusion of aminoglycosides but is a broad-spectrum drug efflux system.
AID1562298	Inhibition of STPK in Mycobacterium smegmatis MC2 155 expressing aminoglycoside phophotransferase-8 assessed as growth inhibition at 350 microg/disk after 18 hrs by paper disk method	2019	European journal of medicinal chemistry, Sep-15, Volume: 178	Synthesis and antimycobacterial activity of imidazo[1,2-b][1,2,4,5]tetrazines.
AID1182137	Antitubercular activity against Mycobacterium smegmatis assessed as reduction in MIC99 by checkerboard assay in presence of chlorpromazine sulfoxide relative to control	2014	Bioorganic & medicinal chemistry, Aug-15, Volume: 22, Issue:16	Pharmacologically active metabolites, combination screening and target identification-driven drug repositioning in antituberculosis drug discovery.
AID400957	Antimicrobial activity against Staphylococcus aureus ATCC 25923 by serial broth microdilution method	2004	Journal of natural products, Apr, Volume: 67, Issue:4	Further labdane and kaurane diterpenoids and other constituents from Plectranthus fruticosus.
AID574584	Antimycobacterial activity against extensively drug-resistant Mycobacterium tuberculosis isolate 625 obtained from sputum of patient at 4 ug/ml by Bactec MGIT960 modified proportion method	2010	Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11	Emergence and molecular characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates from the Delhi Region in India.
AID584340	Antibacterial activity against tolC deficient Escherichia coli GD100 presence of 15 mM of glutathione	2010	Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12	Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics.
AID1710566	Antibacterial activity against Escherichia coli ATCC 25922 assessed as reduction in bacterial growth at 64 uM incubated for 15 to 20 hrs by broth microdilution method relative to control	2018	MedChemComm, Jul-01, Volume: 9, Issue:7	Targeting miRNA by tunable small molecule binders: peptidic aminosugar mediated interference in miR-21 biogenesis reverts epithelial to mesenchymal transition.
AID1337846	Antifungal activity against Aspergillus niger NCIM 1196 by standard agar method	2017	European journal of medicinal chemistry, Jan-05, Volume: 125	Quinolidene-rhodanine conjugates: Facile synthesis and biological evaluation.
AID1585652	Antibacterial activity against methicillin-resistant Staphylococcus aureus after overnight incubation by micro broth dilution analysis	2019	European journal of medicinal chemistry, Jan-15, Volume: 162	Discovery of novel arylethenesulfonyl fluorides as potential candidates against methicillin-resistant of Staphylococcus aureus (MRSA) for overcoming multidrug resistance of bacterial infections.
AID1616907	Antibacterial activity against Mycobacterium smegmatis ATCC 700084 incubated for 24 hrs by broth microdilution method
AID1830090	Antibacterial activity against Staphylococcus aureus assessed as bacterial growth inhibition measured after 16 to 20 hrs by broth dilution method
AID544282	Antimicrobial activity against Enterococcus faecalis NKH12 harboring pMG2200-like and pMG2201-like plasmids after 24 hrs by agar dilution method	2009	Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2	Isolation of VanB-type Enterococcus faecalis strains from nosocomial infections: first report of the isolation and identification of the pheromone-responsive plasmids pMG2200, Encoding VanB-type vancomycin resistance and a Bac41-type bacteriocin, and pMG2
AID278266	Antimicrobial activity against Salmonella enterica serovar Typhimurium CHS18 acrAB::Kan with GyrA S38F mutation	2007	Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2	Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials.
AID523002	Cytotoxicity against human 5637 cells assessed as mild induction of cell death by LDH release assay	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Persistence of uropathogenic Escherichia coli in the face of multiple antibiotics.
AID563512	Antimicrobial activity against cetylpyridinium chloride-resistant Serratia marcescens 011 by broth dilution method	2009	Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12	Mutational upregulation of a resistance-nodulation-cell division-type multidrug efflux pump, SdeAB, upon exposure to a biocide, cetylpyridinium chloride, and antibiotic resistance in Serratia marcescens.
AID544287	Antimicrobial activity against Enterococcus faecalis NKH17 harboring pMG2200-like plasmid after 24 hrs by agar dilution method	2009	Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2	Isolation of VanB-type Enterococcus faecalis strains from nosocomial infections: first report of the isolation and identification of the pheromone-responsive plasmids pMG2200, Encoding VanB-type vancomycin resistance and a Bac41-type bacteriocin, and pMG2
AID1287398	Antimicrobial activity against Klebsiella pneumoniae after 24 hrs by serial two-fold microbroth dilution method	2016	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 26, Issue:6	One-pot synthesis and antimicrobial evaluation of novel 3-cyanopyridine derivatives of (-)-β-pinene.
AID774294	Antimycobacterial activity against cycloserine-resistant Mycobacterium tuberculosis ATCC 35826	2013	Journal of natural products, Oct-25, Volume: 76, Issue:10	Chlorinated coumarins from the polypore mushroom Fomitopsis officinalis and their activity against Mycobacterium tuberculosis.
AID1182144	Antitubercular activity against Mycobacterium smegmatis by checkerboard assay in presence of chlorpromazine sulfoxide	2014	Bioorganic & medicinal chemistry, Aug-15, Volume: 22, Issue:16	Pharmacologically active metabolites, combination screening and target identification-driven drug repositioning in antituberculosis drug discovery.
AID1557264	Antitubercular activity against resistant Mycobacterium tuberculosis harboring rrs A1401G mutant after 3 to 6 weeks	2019	MedChemComm, Aug-01, Volume: 10, Issue:8	Drug-resistance in
AID404902	Antimicrobial activity against Enterococcus faecalis ATCC 29212 by agar dilution method	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	High-level gentamicin resistance mediated by a Tn4001-like transposon in seven nonclonal hospital isolates of Streptococcus pasteurianus.
AID330985	Antimicrobial activity against Staphylococcus epidermis	2007	Nature, May-03, Volume: 447, Issue:7140	PTC124 targets genetic disorders caused by nonsense mutations.
AID523020	Ratio of Kcat to Km for aminoglycoside 3'-phosphotransferase 1B by PK/LDH-coupled assay in presence of ATP	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Nucleotide selectivity of antibiotic kinases.
AID278549	Antimicrobial activity against 90 mins oxgall-stressed Bifidobacterium breve ATCC 15700 after 18 hrs	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID1262362	Antibacterial activity against clinical isolates Staphylococcus aureus after 24 hrs by agar diffusion assay	2015	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 25, Issue:24	PPL catalyzed four-component PASE synthesis of 5-monosubstituted barbiturates: Structure and pharmacological properties.
AID445288	Antibacterial activity against Mycobacterium smegmatis by broth dilution method	2009	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 19, Issue:22	Synthesis of new sugar derivatives and evaluation of their antibacterial activities against Mycobacterium tuberculosis.
AID556564	Antimicrobial activity against sodA, sodB gene-deficient Escherichia coli K-12 3156 by broth dilution method	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	Contribution of oxidative damage to antimicrobial lethality.
AID1263044	Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 at 0.5 mM after 24 to 48 hrs by Kirby-Bauer disc diffusion susceptibility test	2015	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 25, Issue:24	Synthesis and biological evaluation of pyrazolopyrimidines as potential antibacterial agents.
AID529457	Antimicrobial activity against Klebsiella pneumoniae containing PFGE clone B expressing beta-lactamase Oxa-48, TEM-1, CTX-M-15 and Oxa-1 by Etest	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Spread of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in Istanbul, Turkey.
AID368418	Antimicrobial activity against multidrug-resistant Escherichia coli C316 pHPA containing mutated GyrA gene by agar dilution method	2007	Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9	New plasmid-mediated fluoroquinolone efflux pump, QepA, found in an Escherichia coli clinical isolate.
AID1478532	Ratio of MIC for aminoglycosides-resistant Escherichia coli BL21 harboring pETSACG1 encode for APH(3')-3a resistance enzyme to MIC for Escherichia coli BL21	2017	Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11	Covalently linked kanamycin - Ciprofloxacin hybrid antibiotics as a tool to fight bacterial resistance.
AID556560	Antimicrobial activity against Escherichia coli K-12 BW25113 by broth dilution method	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	Contribution of oxidative damage to antimicrobial lethality.
AID369072	Antimicrobial activity against Bacillus subtilis ATCC 6633 after 24 hrs by MTT assay	2009	Bioorganic & medicinal chemistry, Feb-01, Volume: 17, Issue:3	Synthesis, structure and antibacterial activity of new 2-(1-(2-(substituted-phenyl)-5-methyloxazol-4-yl)-3-(2-substitued-phenyl)-4,5-dihydro-1H-pyrazol-5-yl)-7-substitued-1,2,3,4-tetrahydroisoquinoline derivatives.
AID1169513	Antibacterial activity against Escherichia coli after 24 hrs by MTT method	2014	Bioorganic & medicinal chemistry letters, Sep-28	Design, synthesis and biological evaluation of metronidazole-thiazole derivatives as antibacterial inhibitors.
AID1169513	Antibacterial activity against Escherichia coli after 24 hrs by MTT method	2014	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22	Design, synthesis and biological evaluation of metronidazole-thiazole derivatives as antibacterial inhibitors.
AID1617683	Antibacterial activity against Bacillus thuringiensis BT01 by CLSI based two-fold serial dilution method
AID244862	In-vitro minimum inhibitory concentration against the growth of Escherichia coli	2005	Bioorganic & medicinal chemistry letters, Jul-01, Volume: 15, Issue:13	Synthesis of (1,4)-naphthoquinono-[3,2-c]-1H-pyrazoles and their (1,4)-naphthohydroquinone derivatives as antifungal, antibacterial, and anticancer agents.
AID1202743	Antimicrobial activity against Micrococcus luteus assessed as reduction in bacterial growth incubated for 48 hrs by microbroth dilution method	2015	Journal of natural products, Feb-27, Volume: 78, Issue:2	Prenylated benzophenones from Triadenum japonicum.
AID1271377	Antimicrobial activity against Gram-positive Bacillus cereus ATCC 17788 after 16 to 24 hrs by micro-dilution method	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Synthesis and Biological Activity of Mono- and Di-N-acylated Aminoglycosides.
AID584336	Antibacterial activity against wild type Escherichia coli BW25113 presence of 15 mM of glutathione	2010	Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12	Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics.
AID424337	Antibacterial activity against fusidic acid-resistant Staphylococcus aureus AH194 harboring Pro404Leu mutation in fusA gene after 18 to 24 hrs by Etest strip assay	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID69666	Minimum inhibitory concentration (MIC) was measured against Escherichia coli ATCC 25922.	1995	Journal of medicinal chemistry, Nov-10, Volume: 38, Issue:23	Synthesis and antimicrobial and toxicological studies of amino acid and peptide derivatives of kanamycin A and netilmicin.
AID1263045	Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 at 0.1 mM after 24 to 48 hrs by Kirby-Bauer disc diffusion susceptibility test	2015	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 25, Issue:24	Synthesis and biological evaluation of pyrazolopyrimidines as potential antibacterial agents.
AID278234	Antimicrobial activity against Salmonella enterica serovar Typhimurium GyrA S21-1 acrAB::Kan with GyrA S83F mutation	2007	Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2	Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials.
AID1202746	Antimicrobial activity against Candida albicans IFM62680 assessed as reduction in bacterial growth incubated for 48 hrs by microbroth dilution method	2015	Journal of natural products, Feb-27, Volume: 78, Issue:2	Prenylated benzophenones from Triadenum japonicum.
AID1296450	Inhibition of proteosynthesis in Mycobacterium tuberculosis H37Ra assessed as reduction of [14C]-methionine incorporation at 5 ug/ml preincubated for 1 hr followed by radiolabeling with [14C]-methionine for 24 hrs by scintillation spectrometry	2016	Journal of medicinal chemistry, Mar-24, Volume: 59, Issue:6	Development of 3,5-Dinitrobenzylsulfanyl-1,3,4-oxadiazoles and Thiadiazoles as Selective Antitubercular Agents Active Against Replicating and Nonreplicating Mycobacterium tuberculosis.
AID283529	Antibacterial activity against Pseudomonas aeruginosa PAO1 by microdilution method	2007	Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3	Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides.
AID445289	Antibacterial activity against Staphylococcus aureus by broth dilution method	2009	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 19, Issue:22	Synthesis of new sugar derivatives and evaluation of their antibacterial activities against Mycobacterium tuberculosis.
AID1176776	Antimicrobial activity against methicillin-sensitive and vancomycin-intermediate Staphylococcus aureus ATCC 25923 after 24 hrs by broth microdilution method	2015	Journal of natural products, Jan-23, Volume: 78, Issue:1	Structure and antimicrobial activity of phloroglucinol derivatives from Achyrocline satureioides.
AID428872	Antibacterial activity against Escherichia coli JM109 carrying pMCL-BE by agar dilution method	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Novel plasmid-mediated 16S rRNA m1A1408 methyltransferase, NpmA, found in a clinically isolated Escherichia coli strain resistant to structurally diverse aminoglycosides.
AID424346	Antibacterial activity against fusidic acid-resistant Staphylococcus aureus AH193 harboring TAA stop codon at nucleotide 299 in rplF gene after 18 to 24 hrs by Etest strip assay	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID434367	Antibacterial activity against Staphylococcus aureus ATCC 25923 after 24 hrs by broth microdilution method	2009	European journal of medicinal chemistry, Aug, Volume: 44, Issue:8	Design, synthesis and biological evaluation of novel nitrogen and sulfur containing hetero-1,4-naphthoquinones as potent antifungal and antibacterial agents.
AID540212	Mean residence time in human after iv administration	2008	Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7	Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
AID584328	Antibacterial activity against gshB deficient Escherichia coli JW2914-1	2010	Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12	Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics.
AID1866148	Antibacterial activity against Mycobacterium smegmatis ATCC 700084 assessed as inhibition of bacterial growth incubated for overnight by serial dilution method
AID1879067	Antibacterial activity against pET28a-NDM-1 positive Escherichia coli BL21(DE3) isolates assessed as inhibition of bacterial growth incubated for 18 to 24 hrs by CLSI based broth microdilution method	2022	European journal of medicinal chemistry, Mar-05, Volume: 231	Metallo-β-lactamases inhibitor fisetin attenuates meropenem resistance in NDM-1-producing Escherichia coli.
AID774292	Selectivity index, ratio of IC50 for african green monkey Vero cells to MIC90 for Mycobacterium tuberculosis H37Rv ATCC 27294 by microplate Alamar blue assay	2013	Journal of natural products, Oct-25, Volume: 76, Issue:10	Chlorinated coumarins from the polypore mushroom Fomitopsis officinalis and their activity against Mycobacterium tuberculosis.
AID574809	Antimycobacterial activity against extensively drug-resistant Mycobacterium tuberculosis isolate 2474 horboring rpoB H526Y, katG D329A/R463L, gyrA D94G/S95T, rrs A1401G by CLSI method	2010	Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11	Emergence and molecular characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates from the Delhi Region in India.
AID278242	Antimicrobial activity against Salmonella enterica serovar Typhimurium S21-3 acrAB::Kan with GyrA S83F, ParC S80I mutation	2007	Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2	Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials.
AID278801	Antimicrobial activity against recombinant Escherichia coli DH5alpha expressing pBAD	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Aph(3')-IIc, an aminoglycoside resistance determinant from Stenotrophomonas maltophilia.
AID1132235	Antibacterial activity against pigmented Serratia 155 assessed as growth inhibition by agar dilution method	1978	Journal of medicinal chemistry, Feb, Volume: 21, Issue:2	Chemical modification of 1,4-diamino-1,4-dideoxy-3-O-(4-deoxy-4-propionamido-alpha-D-glucopyranosyl)-D-glucitol.
AID1413331	Antifungal activity against resistant Candida albicans ATCC 64124	2018	MedChemComm, Jun-01, Volume: 9, Issue:6	Antifungal amphiphilic kanamycins: new life for an old drug.
AID569262	Antimicrobial activity against Escherichia coli DH5alpha	2011	Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3	Synthesis and evaluation of anti-tubercular activity of new dithiocarbamate sugar derivatives.
AID523004	Antibacterial activity against uropathogenic Escherichia coli UTI89 assessed as degradation of preexisting biofilm after 24 hrs by microscopy	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Persistence of uropathogenic Escherichia coli in the face of multiple antibiotics.
AID330987	Antimicrobial activity against Enterococcus faecalis 29212	2007	Nature, May-03, Volume: 447, Issue:7140	PTC124 targets genetic disorders caused by nonsense mutations.
AID530050	Antimicrobial activity against Staphylococcus aureus 286607-R1 by broth microdilution method	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Discovery and characterization of QPT-1, the progenitor of a new class of bacterial topoisomerase inhibitors.
AID1426252	Antibacterial activity against Escherichia coli ATCC 25922	2017	European journal of medicinal chemistry, Jan-27, Volume: 126	Synthesis and bioactivity investigation of quinone-based dimeric cationic triazolium amphiphiles selective against resistant fungal and bacterial pathogens.
AID1167351	Antibacterial activity against Pseudomonas aeruginosa PAO1 mexAB/mexCD/mexXY/mexHI/opmH deletion mutant after 18 to 24 hrs by two-fold broth microdilution method	2014	Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21	Design, synthesis, and antibacterial properties of dual-ligand inhibitors of acetyl-CoA carboxylase.
AID1663462	Antibacterial activity against methicillin-resistant Staphylococcus aureus shhs-A1 incubated for 16 hrs by broth microdilution method	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Antibacterial Pentacyclic Polyketides from a Soil-Derived
AID278240	Antimicrobial activity against Salmonella enterica serovar Typhimurium S21-3 with GyrA S83F, ParC S80I mutation	2007	Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2	Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials.
AID290144	Antibacterial activity against Bacillus subtilis after 24 hrs by MTT colorimetric method	2007	European journal of medicinal chemistry, Apr, Volume: 42, Issue:4	Synthesis and antimicrobial activities of Schiff bases derived from 5-chloro-salicylaldehyde.
AID164255	Antibacterial activity expressed as MIC value was determined on Pseudomonas aeruginosa A-21294 organism	1986	Journal of medicinal chemistry, May, Volume: 29, Issue:5	Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin.
AID1337841	Antifungal activity against Candida albicans NCIM 3471 by standard agar method	2017	European journal of medicinal chemistry, Jan-05, Volume: 125	Quinolidene-rhodanine conjugates: Facile synthesis and biological evaluation.
AID540929	Antimicrobial activity against paromomycin-resistant Streptomyces coelicolor KO-347 harboring rpsl P91S mutant gene after 48 hrs	2009	Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3	A novel insertion mutation in Streptomyces coelicolor ribosomal S12 protein results in paromomycin resistance and antibiotic overproduction.
AID520701	Antibacterial activity against tnpR/tnpA positive tetracycline resistant Streptococcus pneumoniae clinical isolate expressing Tn3872 carrying erm(B) and tet(M) gene at 1000 ug by disk diffusion method	2008	Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4	erm(B)-carrying elements in tetracycline-resistant pneumococci and correspondence between Tn1545 and Tn6003.
AID584329	Antibacterial activity against gspS deficient Escherichia coli JW2956-1	2010	Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12	Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics.
AID163280	Minimum inhibitory concentration (MIC) was measured against Pseudomonas aeruginosa.	1995	Journal of medicinal chemistry, Nov-10, Volume: 38, Issue:23	Synthesis and antimicrobial and toxicological studies of amino acid and peptide derivatives of kanamycin A and netilmicin.
AID1478536	Inhibition of Escherichia coli DNA gyrase using relaxed pBR322 DNA as substrate by agarose gel electrophorosis method	2017	Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11	Covalently linked kanamycin - Ciprofloxacin hybrid antibiotics as a tool to fight bacterial resistance.
AID1443980	Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate transport preincubated for 10 mins prior to ATP addition measured after 15 mins in presence of [3H]-tauroch	2010	Toxicological sciences : an official journal of the Society of Toxicology, Dec, Volume: 118, Issue:2	Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
AID1326386	Antibacterial activity against Bacillus subtilis P10B derived after 10 passage in presence of JBIR-100 after 16 to 18 hrs by microbroth dilution assay	2016	Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24	Biological characterization of the hygrobafilomycin antibiotic JBIR-100 and bioinformatic insights into the hygrolide family of natural products.
AID1271380	Antimicrobial activity against Gram-positive Staphylococcus aureus ATCC 29213 after 16 to 24 hrs by micro-dilution method	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Synthesis and Biological Activity of Mono- and Di-N-acylated Aminoglycosides.
AID1337798	Antibacterial activity against Escherichia coli NCIM 2688 measured after 8 hrs	2017	European journal of medicinal chemistry, Jan-05, Volume: 125	Quinolidene-rhodanine conjugates: Facile synthesis and biological evaluation.
AID404900	Antibacterial activity against high-level gentamicin resistant Streptococcus pasteurianus SB40 isolate carrying transposon-borne resistance gene [aac(6')Ie-aph(2'')Ia] by agar dilution method	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	High-level gentamicin resistance mediated by a Tn4001-like transposon in seven nonclonal hospital isolates of Streptococcus pasteurianus.
AID278526	Antimicrobial activity against Bifidobacterium infantis ATCC 15697	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID342021	Antibacterial activity against Klebsiella pneumoniae NK29 by broth microdilution test	2007	Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8	Sequencing and comparative genomic analysis of pK29, a 269-kilobase conjugative plasmid encoding CMY-8 and CTX-M-3 beta-lactamases in Klebsiella pneumoniae.
AID278562	Antimicrobial activity against 90 mins hydrogen peroxide-stressed Bifidobacterium breve R0070 after 18 hrs	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID1167355	Antibacterial activity against moiramide-resistant Escherichia coli D21 tolC deletion mutant after 18 to 24 hrs by two-fold broth microdilution method	2014	Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21	Design, synthesis, and antibacterial properties of dual-ligand inhibitors of acetyl-CoA carboxylase.
AID207039	Antibacterial activity expressed as MIC value was determined on Staphylococcus aureus A-21978 organism	1986	Journal of medicinal chemistry, May, Volume: 29, Issue:5	Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin.
AID330986	Antimicrobial activity against Enterococcus faecium 49624	2007	Nature, May-03, Volume: 447, Issue:7140	PTC124 targets genetic disorders caused by nonsense mutations.
AID1413332	Antifungal activity against sensitive Candida albicans MYA-2876	2018	MedChemComm, Jun-01, Volume: 9, Issue:6	Antifungal amphiphilic kanamycins: new life for an old drug.
AID1413330	Antifungal activity against Candida albicans ATCC 10231	2018	MedChemComm, Jun-01, Volume: 9, Issue:6	Antifungal amphiphilic kanamycins: new life for an old drug.
AID1830087	Antibacterial activity against Bacillus subtilis E168 assessed as bacterial growth inhibition measured after 16 to 20 hrs by broth dilution method
AID278253	Antimicrobial activity against Salmonella enterica serovar Typhimurium CS3 gyrA+ with GyrA S83F, D87N, ParC S80I mutation	2007	Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2	Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials.
AID460286	Antibacterial activity against aminoglycoside-susceptible Staphylococcus aureus ATCC 25923 after 12 to 18 hrs	2010	Bioorganic & medicinal chemistry, Feb-15, Volume: 18, Issue:4	Synthesis of novel aminoglycosides via allylic azide rearrangement for investigating the significance of 2'-amino group.
AID1326390	Antibacterial activity against Bacillus subtilis P10C derived after 10 passage in presence of JBIR-100 after 16 to 18 hrs by microbroth dilution assay relative to Bacillus subtilis ATCC 47096	2016	Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24	Biological characterization of the hygrobafilomycin antibiotic JBIR-100 and bioinformatic insights into the hygrolide family of natural products.
AID69667	Minimum inhibitory concentration (MIC) was measured against Escherichia coli ATCC 35218.	1995	Journal of medicinal chemistry, Nov-10, Volume: 38, Issue:23	Synthesis and antimicrobial and toxicological studies of amino acid and peptide derivatives of kanamycin A and netilmicin.
AID1164944	Antimicrobial activity against tolC-deficient Escherichia coli by microbroth dilution method	2014	Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20	Synthesis, structure-activity relationship studies, and antibacterial evaluation of 4-chromanones and chalcones, as well as olympicin A and derivatives.
AID584823	Inactivation of Pseudomonas putida PAW340 biofilms assessed as decrease in heat production at 3 to 30 ug/ml by Chip calorimetry	2010	Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1	Chip calorimetry for fast and reliable evaluation of bactericidal and bacteriostatic treatments of biofilms.
AID69665	Minimum inhibitory concentration (MIC) was measured against Escherichia coli.	1995	Journal of medicinal chemistry, Nov-10, Volume: 38, Issue:23	Synthesis and antimicrobial and toxicological studies of amino acid and peptide derivatives of kanamycin A and netilmicin.
AID601493	Antibacterial activity against Staphylococcus aureus MTCC 2940 at 30 ug/disc after 24 hrs	2011	European journal of medicinal chemistry, Jun, Volume: 46, Issue:6	Evaluation of antioxidant and antimicrobial activities of Bergenin and its derivatives obtained by chemoenzymatic synthesis.
AID424570	Antibacterial activity against stationary-phase rifampin-resistant Staphylococcus aureus 8325-4 culture assessed as number of viable colonies at 16 ug/ ml after 48 hrs	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID1265791	Antibacterial activity against Staphylococcus aureus NRS383 (USA 200) by microdilution method	2015	Journal of medicinal chemistry, Dec-10, Volume: 58, Issue:23	Synthesis and Bioactivities of Kanamycin B-Derived Cationic Amphiphiles.
AID524390	Antibacterial activity against Escherichia coli NKE1316 harboring deletion mutation in acrB, acrD and mdtABC protein	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Effect of NlpE overproduction on multidrug resistance in Escherichia coli.
AID420207	Antimicrobial activity against Pseudomonas aeruginosa UFPEDA 39 at 30 ug/disk after 24 hrs by disk diffusion method	2009	European journal of medicinal chemistry, May, Volume: 44, Issue:5	Synthesis, antimicrobial and cytotoxic activities of some 5-arylidene-4-thioxo-thiazolidine-2-ones.
AID1869565	Antibacterial activity against Enterococcus faecium DSM 20477 assessed as reduction in bacterial growth measured after 3 days by broth microdilution method	2022	Journal of natural products, 06-24, Volume: 85, Issue:6	Triculamin: An Unusual Lasso Peptide with Potent Antimycobacterial Activity.
AID1455937	Antifungal activity against Aspergillus niger after 96 hrs by broth micro-dilution method	2017	Journal of natural products, 02-24, Volume: 80, Issue:2	Nabscessins A and B, Aminocyclitol Derivatives from Nocardia abscessus IFM 10029
AID283559	Antibacterial activity against Escherichia coli AG102MB after 24 hrs	2007	Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3	Substrate competition studies using whole-cell accumulation assays with the major tripartite multidrug efflux pumps of Escherichia coli.
AID1551812	Antibacterial activity against Bacillus anthracis incubated for 18 hrs post 30 mins pre-diffusion by disk diffusion method	2019	European journal of medicinal chemistry, Jul-01, Volume: 173	Antibacterial activity study of 1,2,4-triazole derivatives.
AID560600	Antimicrobial activity against Escherichia coli JM109 transformant harboring pSTV28 plasmid expressing aac(6')-Iaf (TTG-ATG) mutant gene by microdilution method	2009	Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6	AAC(6')-Iaf, a novel aminoglycoside 6'-N-acetyltransferase from multidrug-resistant Pseudomonas aeruginosa clinical isolates.
AID1491153	Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate shhs-A1 by CLSI method	2017	Journal of natural products, 05-26, Volume: 80, Issue:5	Antimicrobial Spirotetronate Metabolites from Marine-Derived Micromonospora harpali SCSIO GJ089.
AID278557	Antimicrobial activity against 90 mins oxgall-stressed Bifidobacterium thermophilum ATCC 25866 after 18 hrs	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID1202744	Antimicrobial activity against Aspergillus niger IFM62678 assessed as reduction in bacterial growth incubated for 48 hrs by microbroth dilution method	2015	Journal of natural products, Feb-27, Volume: 78, Issue:2	Prenylated benzophenones from Triadenum japonicum.
AID1262359	Antibacterial activity against clinical isolate Gram-positive Bacillus subtilis after 24 hrs by agar diffusion assay	2015	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 25, Issue:24	PPL catalyzed four-component PASE synthesis of 5-monosubstituted barbiturates: Structure and pharmacological properties.
AID625283	Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for elevated liver function tests	2011	PLoS computational biology, Dec, Volume: 7, Issue:12	Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID1474166	Liver toxicity in human assessed as induction of drug-induced liver injury by measuring severity class index	2016	Drug discovery today, Apr, Volume: 21, Issue:4	DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
AID163279	Minimum inhibitory concentration (MIC) was measured against Pseudomonas aeruginosa ATCC 27853.	1995	Journal of medicinal chemistry, Nov-10, Volume: 38, Issue:23	Synthesis and antimicrobial and toxicological studies of amino acid and peptide derivatives of kanamycin A and netilmicin.
AID1585675	Antibiofilm activity against methicillin-resistant Staphylococcus aureus at 2 times MIC after 24 hrs by crystal violet staining-based UV-visible spectrophotometric analysis	2019	European journal of medicinal chemistry, Jan-15, Volume: 162	Discovery of novel arylethenesulfonyl fluorides as potential candidates against methicillin-resistant of Staphylococcus aureus (MRSA) for overcoming multidrug resistance of bacterial infections.
AID326536	Antimicrobial activity against Mycobacterium abscessus CH10 isolate after 3 to 5 days by broth microdilution method	2007	Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5	In Vitro activities of isepamicin, other aminoglycosides, and capreomycin against clinical isolates of rapidly growing mycobacteria in Taiwan.
AID283560	Antibacterial activity against Escherichia coli HNCE4 after 24 hrs	2007	Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3	Substrate competition studies using whole-cell accumulation assays with the major tripartite multidrug efflux pumps of Escherichia coli.
AID1467594	Antibacterial activity against Klebsiella pneumoniae NBRC 14940 after 12 hrs by MTT assay	2017	Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14	New merosesquiterpenes from a Vietnamese marine sponge of Spongia sp. and their biological activities.
AID532989	Antibacterial activity against Klebsiella aerogenes NCIM 2281 in presence of 10 mM N-Acetylcysteine	2010	Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8	N-acetylcysteine-mediated modulation of bacterial antibiotic susceptibility.
AID1653391	Anti-leprotic activity against Mycobacterium leprae infected in BALB/c weanling mouse assessed as bacteria killing at 100 mg/kg, ip administrated for 60 days and measured after 1 year by most probable number technique analysis relative to control	2019	Bioorganic & medicinal chemistry, 07-01, Volume: 27, Issue:13	Insights of synthetic analogues of anti-leprosy agents.
AID278547	Antimicrobial activity against 90 mins oxgall-stressed Bifidobacterium bifidum ATCC 15696 after 18 hrs	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID1565712	Antifungal activity against Candida tropicalis 95-41 incubated for 24 to 36 hrs by two fold dilution method	2019	European journal of medicinal chemistry, Nov-15, Volume: 182	Scalable and cost-effective tosylation-mediated synthesis of antifungal and fungal diagnostic 6″-Modified amphiphilic kanamycins.
AID1868104	Antibacterial activity against methicillin-resistant Staphylococcus aureus clinical isolate 3B assessed as inhibition of visible bacterial growth incubated for 18 hrs by CLSI protocol based assay	2022	Journal of natural products, 05-27, Volume: 85, Issue:5	Enceleamycins A-C, Furo-Naphthoquinones from
AID563504	Antimicrobial activity against Serratia marcescens ATCC 13880 harboring plasmid STV29 by broth dilution method	2009	Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12	Mutational upregulation of a resistance-nodulation-cell division-type multidrug efflux pump, SdeAB, upon exposure to a biocide, cetylpyridinium chloride, and antibiotic resistance in Serratia marcescens.
AID574170	Antibacterial activity against Escherichia coli MG1655 grown as biofilms harboring plasmid pBR322 carrying blaTEM-1 and tetA(C) genes after 24 hrs by agar dilution method	2009	Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11	Induction of multidrug resistance mechanism in Escherichia coli biofilms by interplay between tetracycline and ampicillin resistance genes.
AID1868099	Antibacterial activity against Bacillus cereus ATCC 11778 assessed as inhibition of visible bacterial growth incubated for 18 hrs by CLSI protocol based assay	2022	Journal of natural products, 05-27, Volume: 85, Issue:5	Enceleamycins A-C, Furo-Naphthoquinones from
AID1869567	Antibacterial activity against Staphylococcus aureus DSM 20231 assessed as reduction in bacterial growth measured after 3 days by broth microdilution method	2022	Journal of natural products, 06-24, Volume: 85, Issue:6	Triculamin: An Unusual Lasso Peptide with Potent Antimycobacterial Activity.
AID1334269	Antibacterial activity against Bacillus subtilis	2017	Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2	New bithiazolyl hydrazones: Novel synthesis, characterization and antitubercular evaluation.
AID164251	Antibacterial activity expressed as MIC value was determined on Pseudomonas aeruginosa A-20653 organism	1986	Journal of medicinal chemistry, May, Volume: 29, Issue:5	Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin.
AID1866813	Antifungal activity against Escherichia coli assessed as reduction in microbial growth after 24 hrs by two-fold dilution method	2022	Journal of natural products, 04-22, Volume: 85, Issue:4	Secondary Metabolites from
AID1869570	Bactericidal activity against Klebsiella oxytoca DSM 5175 assessed as reduction in colony count and measured after 3 days by agar diffusion assay	2022	Journal of natural products, 06-24, Volume: 85, Issue:6	Triculamin: An Unusual Lasso Peptide with Potent Antimycobacterial Activity.
AID428870	Antibacterial activity against Escherichia coli CSH-2 carrying Escherichia coli ARS3 pARS3 by agar dilution method	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Novel plasmid-mediated 16S rRNA m1A1408 methyltransferase, NpmA, found in a clinically isolated Escherichia coli strain resistant to structurally diverse aminoglycosides.
AID1730998	Antibacterial activity against Staphylococcus aureus Newman assessed as inhibition of bacterial growth measured after 18 hrs by two fold serial dilution method	2021	European journal of medicinal chemistry, Mar-05, Volume: 213	Design and synthesis of mycobacterial pks13 inhibitors: Conformationally rigid tetracyclic molecules.
AID532987	Antibacterial activity against Pseudomonas aeruginosa NCIM 5029 in presence of 10 mM N-Acetylcysteine	2010	Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8	N-acetylcysteine-mediated modulation of bacterial antibiotic susceptibility.
AID540930	Antimicrobial activity against paromomycin-resistant Streptomyces coelicolor 92G harboring rpsL gene with inserted glycine at position 92 after 48 hrs	2009	Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3	A novel insertion mutation in Streptomyces coelicolor ribosomal S12 protein results in paromomycin resistance and antibiotic overproduction.
AID278270	Antimicrobial activity against Salmonella enterica serovar Typhimurium CHS38 acrAB::Kan with GyrA D87G mutation	2007	Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2	Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials.
AID1326369	Antibacterial activity against Bacillus subtilis ATCC 47096 after 16 to 18 hrs by microbroth dilution assay	2016	Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24	Biological characterization of the hygrobafilomycin antibiotic JBIR-100 and bioinformatic insights into the hygrolide family of natural products.
AID1228000	Antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as inhibition of visible bacterial growth incubated for 24 hrs at 37 degC by broth microdilution method	2015	Journal of natural products, Apr-24, Volume: 78, Issue:4	Antibacterial Polyketide Heterodimers from Pyrenacantha kaurabassana Tubers.
AID424825	Antibacterial activity against kanamycin-resistant and fusidic acid-susceptible Staphylococcus aureus AH292 harboring Gly664Val mutation in fusA gene after 18 to 24 hrs by Etest strip assay	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID625288	Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for jaundice	2011	PLoS computational biology, Dec, Volume: 7, Issue:12	Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID1629123	Antimicrobial activity against Pseudomonas aeruginosa ATCC 27853 measured after 24 hrs by double-dilution method	2016	Journal of medicinal chemistry, 09-08, Volume: 59, Issue:17	Effects of 5-O-Ribosylation of Aminoglycosides on Antimicrobial Activity and Selective Perturbation of Bacterial Translation.
AID1287416	Antimycobacterial activity against Mycobacterium bovis BCG overexpressing InhA after 2 weeks	2016	European journal of medicinal chemistry, Apr-13, Volume: 112	New direct inhibitors of InhA with antimycobacterial activity based on a tetrahydropyran scaffold.
AID1557266	Antitubercular activity against resistant Mycobacterium tuberculosis harboring rrs G1484T/C-12T mutant after 3 to 6 weeks	2019	MedChemComm, Aug-01, Volume: 10, Issue:8	Drug-resistance in
AID1077166	Antibacterial activity against Bacillus subtilis after 12 hrs by MTT assay	2014	European journal of medicinal chemistry, Apr-09, Volume: 76	Design and synthesis of 2-styryl of 5-Nitroimidazole derivatives and antimicrobial activities as FabH inhibitors.
AID1230066	Antibacterial activity against methicillin-resistant Staphylococcus aureus GRE2691 assessed as inhibition of bacterial growth	2015	Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13	Synthesis and antimicrobial activity of chloramphenicol-polyamine conjugates.
AID532031	Antimicrobial activity against Escherichia coli TOP10F' by disk diffusion method	2010	Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7	Novel chromosome-encoded CTX-M-78 beta-lactamase from a Kluyvera georgiana clinical isolate as a putative origin of CTX-M-25 subgroup.
AID283648	Susceptibility of Escherichia coli K12 MG1655 in presence of 10 mM glutathione by agar dilution method relative to control	2007	Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3	Effects of glutathione and ascorbic acid on streptomycin sensitivity of Escherichia coli.
AID718274	Antimicrobial activity against Staphylococcus aureus ATCC 29213	2012	Journal of natural products, Dec-28, Volume: 75, Issue:12	Marthiapeptide A, an anti-infective and cytotoxic polythiazole cyclopeptide from a 60 L scale fermentation of the deep sea-derived Marinactinospora thermotolerans SCSIO 00652.
AID551748	Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 33591 after 12 to 18 hrs by twofold dilution method	2011	Bioorganic & medicinal chemistry, Jan-01, Volume: 19, Issue:1	Synthesis and antibacterial activity study of a novel class of cationic anthraquinone analogs.
AID771494	Antibacterial activity against Escherichia coli by dilution technique	2013	European journal of medicinal chemistry, Oct, Volume: 68	Synthesis and biological evaluation of novel ocotillol-type triterpenoid derivatives as antibacterial agents.
AID1402054	Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 after 18 to 20 hrs by spectrophotometry based microdilution method	2018	European journal of medicinal chemistry, Jan-01, Volume: 143	Synthesis and antimicrobial activity of amino acid and peptide derivatives of mycophenolic acid.
AID1629125	Antimicrobial activity against Haemophilus influenzae ATCC 10211 measured after 24 hrs by double-dilution method	2016	Journal of medicinal chemistry, 09-08, Volume: 59, Issue:17	Effects of 5-O-Ribosylation of Aminoglycosides on Antimicrobial Activity and Selective Perturbation of Bacterial Translation.
AID1079935	Cytolytic liver toxicity, either proven histopathologically or where the ratio of maximal ALT or AST activity above normal to that of Alkaline Phosphatase is > 5 (see ACUTE). Value is number of references indexed. [column 'CYTOL' in source]
AID1594069	Antibacterial activity against Staphylococcus aureus assessed as reduction in bacterial cell viability incubated for 20 to 24 hrs by REMA method	2019	Bioorganic & medicinal chemistry, 06-15, Volume: 27, Issue:12	Design, synthesis, in-silico studies and biological screening of quinazolinone analogues as potential antibacterial agents against MRSA.
AID501181	Antimicrobial activity against vancomycin-resistant Enterococcus faecium 379 at 30 ug after 18 hrs by agar diffusion method	2009	Journal of natural products, Oct, Volume: 72, Issue:10	Norselic acids A-E, highly oxidized anti-infective steroids that deter mesograzer predation, from the Antarctic sponge Crella sp.
AID1347681	Toxicity against Yersinia pseudotuberculosis harboring pYV deletion mutant at 50 ug/ml measured after 8 hrs by MTT assay	2017	Journal of natural products, 12-22, Volume: 80, Issue:12	Investigation of the Physical and Bioactive Properties of Bromo- and Iodo-Containing Sponge-Derived Compounds Possessing an Oxyphenylethanamine Core.
AID1132223	Antibacterial activity against drug-sensitive Staphylococcus aureus 2985 assessed as growth inhibition by agar dilution method	1978	Journal of medicinal chemistry, Feb, Volume: 21, Issue:2	Chemical modification of 1,4-diamino-1,4-dideoxy-3-O-(4-deoxy-4-propionamido-alpha-D-glucopyranosyl)-D-glucitol.
AID434366	Antibacterial activity against Escherichia coli after 24 hrs by broth microdilution method	2009	European journal of medicinal chemistry, Aug, Volume: 44, Issue:8	Design, synthesis and biological evaluation of novel nitrogen and sulfur containing hetero-1,4-naphthoquinones as potent antifungal and antibacterial agents.
AID1585459	Antibacterial activity against Staphylococcus aureus Newman measured after 16 hrs	2019	European journal of medicinal chemistry, Jan-15, Volume: 162	Design, synthesis and evaluation of hybrid of tetrahydrocarbazole with 2,4-diaminopyrimidine scaffold as antibacterial agents.
AID278554	Antimicrobial activity against 90 mins oxgall-stressed Bifidobacterium longum R0175 after 18 hrs	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID647788	Antibacterial activity Staphylococcus aureus at 40 ug/disc after 24 hrs by agar disc diffusion method	2012	European journal of medicinal chemistry, Apr, Volume: 50	Synthesis of new α aminophosphonate system bearing Indazole moiety and their biological activity.
AID424599	Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH357 (SCV-29) harboring TAA stop codon at nucleotide 301 in rplF gene after 18 to 24 hrs by Etest strip assay	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID1730991	Antitubercular activity against drug susceptible Mycobacterium tuberculosis V4207 by MABA assay	2021	European journal of medicinal chemistry, Mar-05, Volume: 213	Design and synthesis of mycobacterial pks13 inhibitors: Conformationally rigid tetracyclic molecules.
AID326544	Antimicrobial activity against Mycobacterium abscessus R50 isolate after 3 to 5 days by broth microdilution method	2007	Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5	In Vitro activities of isepamicin, other aminoglycosides, and capreomycin against clinical isolates of rapidly growing mycobacteria in Taiwan.
AID518754	Microbicidal activity against Nonomuraea sp. ATCC 39727 at 5000 ug/ml after 24 hrs	2010	Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6	Novel mechanism of glycopeptide resistance in the A40926 producer Nonomuraea sp. ATCC 39727.
AID283532	Antibacterial activity against Pseudomonas aeruginosa FE53 with inactivated mexZ gene by microdilution method	2007	Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3	Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides.
AID163075	Antibacterial activity expressed as MIC value was determined on Proteus stuartii A-20894 organism	1986	Journal of medicinal chemistry, May, Volume: 29, Issue:5	Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin.
AID569256	Antimycobacterial activity against Mycobacterium bovis BCG str. Tokyo 172	2011	Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3	Synthesis and evaluation of anti-tubercular activity of new dithiocarbamate sugar derivatives.
AID1347679	Toxicity against wild-type Yersinia pseudotuberculosis at 50 ug/ml measured after 15 hrs by MTT assay	2017	Journal of natural products, 12-22, Volume: 80, Issue:12	Investigation of the Physical and Bioactive Properties of Bromo- and Iodo-Containing Sponge-Derived Compounds Possessing an Oxyphenylethanamine Core.
AID750184	Antibacterial activity against Pseudomonas fluorescens ATCC 13525 assessed as growth inhibition after 24 hrs by two-fold serial dilution method	2013	European journal of medicinal chemistry, Jun, Volume: 64	Synthesis and antimicrobical evaluation of a novel class of 1,3,4-thiadiazole: derivatives bearing 1,2,4-triazolo[1,5-a]pyrimidine moiety.
AID420208	Antimicrobial activity against Escherichia coli UFPEDA 224 at 30 ug/disk after 24 hrs by disk diffusion method	2009	European journal of medicinal chemistry, May, Volume: 44, Issue:5	Synthesis, antimicrobial and cytotoxic activities of some 5-arylidene-4-thioxo-thiazolidine-2-ones.
AID425074	Antimicrobial activity against Escherichia coli DH10B in presence of IPTG	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Complex class 1 integrons with diverse variable regions, including aac(6')-Ib-cr, and a novel allele, qnrB10, associated with ISCR1 in clinical enterobacterial isolates from Argentina.
AID71052	Compound was tested for photoinhibition of Escherichia coli (CIP 548T); No data	1998	Bioorganic & medicinal chemistry letters, Nov-03, Volume: 8, Issue:21	Nitroglycosylated meso-arylporphyrins as photoinhibitors of gram positive bacteria.
AID509449	Antibacterial activity against Pseudomonas fluorescens after 24 hrs by MTT assay	2010	European journal of medicinal chemistry, Sep, Volume: 45, Issue:9	Design and synthesis of potent inhibitors of beta-ketoacyl-acyl carrier protein synthase III (FabH) as potential antibacterial agents.
AID126449	Dissociation constant for binding to mitochondrial 12S rRNA construct M2 was determined	2002	Bioorganic & medicinal chemistry letters, Aug-19, Volume: 12, Issue:16	Decoding region bubble size and aminoglycoside antibiotic binding.
AID424827	Antibacterial activity against kanamycin-resistant and fusidic acid-susceptible Staphylococcus aureus AH422 harboring +2 frameshift mutation at nucleotide 222 in rplF gene after 18 to 24 hrs by Etest strip assay	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID523022	Ratio of Kcat to Km for aminoglycoside 3'-phosphotransferase 1B by PK/LDH-coupled assay in presence of GTP	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Nucleotide selectivity of antibiotic kinases.
AID1348090	Antimicrobial activity against Escherichia coli ATCC 25922 assessed as zone of inhibition at 50 ug per disc after 24 hrs by disc diffusion assay	2018	European journal of medicinal chemistry, Jan-01, Volume: 143	Synthesis of new 1-benzyl tetrahydropyridinylidene ammonium salts and their antimicrobial and anticellular activities.
AID1869563	Antibacterial activity against Bacillus cereus DSM 31 assessed as reduction in bacterial growth measured after 3 days by broth microdilution method	2022	Journal of natural products, 06-24, Volume: 85, Issue:6	Triculamin: An Unusual Lasso Peptide with Potent Antimycobacterial Activity.
AID647792	Antibacterial activity Pseudomonas aeruginosa at 40 ug/disc after 24 hrs by agar disc diffusion method	2012	European journal of medicinal chemistry, Apr, Volume: 50	Synthesis of new α aminophosphonate system bearing Indazole moiety and their biological activity.
AID563510	Antimicrobial activity against cetylpyridinium chloride-resistant Serratia marcescens HMS011 by broth dilution method	2009	Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12	Mutational upregulation of a resistance-nodulation-cell division-type multidrug efflux pump, SdeAB, upon exposure to a biocide, cetylpyridinium chloride, and antibiotic resistance in Serratia marcescens.
AID1132240	Antibacterial activity against drug-sensitive Brucella 965 assessed as growth inhibition by agar dilution method	1978	Journal of medicinal chemistry, Feb, Volume: 21, Issue:2	Chemical modification of 1,4-diamino-1,4-dideoxy-3-O-(4-deoxy-4-propionamido-alpha-D-glucopyranosyl)-D-glucitol.
AID278531	Antimicrobial activity against Bifidobacterium pseudolongum ATCC 25562	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID1565713	Antifungal activity against Cryptococcus neoformans H99 incubated for 24 to 36 hrs by two fold dilution method	2019	European journal of medicinal chemistry, Nov-15, Volume: 182	Scalable and cost-effective tosylation-mediated synthesis of antifungal and fungal diagnostic 6″-Modified amphiphilic kanamycins.
AID1657553	Antimicrobial activity against Staphylococcus aureus incubated for 7 hrs by alamar Blue assay
AID537735	Binding affinity to Candida albicans CaMdr1p expressed in yeast AD1-8u	2010	European journal of medicinal chemistry, Nov, Volume: 45, Issue:11	Analysis of physico-chemical properties of substrates of ABC and MFS multidrug transporters of pathogenic Candida albicans.
AID405822	Antimicrobial activity against Escherichia coli DH5alpha	2007	Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7	Characterization of an integron carrying blaIMP-1 and a new aminoglycoside resistance gene, aac(6')-31, and its dissemination among genetically unrelated clinical isolates in a Brazilian hospital.
AID1585460	Antibacterial activity against aminoglycosides/tetracycline-resistant Staphylococcus aureus NRS-1 measured after 16 hrs	2019	European journal of medicinal chemistry, Jan-15, Volume: 162	Design, synthesis and evaluation of hybrid of tetrahydrocarbazole with 2,4-diaminopyrimidine scaffold as antibacterial agents.
AID476721	Antibacterial activity against Pseudomonas aeruginosa ATCC 13525 after 24 hrs by colorimetric method using dye MTT	2010	Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7	Synthesis, molecular modeling and biological evaluation of PSB as targeted antibiotics.
AID718271	Antimicrobial activity against Aeromonas hydrophila subsp. hydrophila ATCC 7966	2012	Journal of natural products, Dec-28, Volume: 75, Issue:12	Marthiapeptide A, an anti-infective and cytotoxic polythiazole cyclopeptide from a 60 L scale fermentation of the deep sea-derived Marinactinospora thermotolerans SCSIO 00652.
AID1271384	Antimicrobial activity against Gram-negative Pseudomonas aeruginosa PAO1 after 16 to 24 hrs by micro-dilution method	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Synthesis and Biological Activity of Mono- and Di-N-acylated Aminoglycosides.
AID544275	Antimicrobial activity against Enterococcus faecalis NKH5 harboring pMG2200-like plasmid after 24 hrs by agar dilution method	2009	Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2	Isolation of VanB-type Enterococcus faecalis strains from nosocomial infections: first report of the isolation and identification of the pheromone-responsive plasmids pMG2200, Encoding VanB-type vancomycin resistance and a Bac41-type bacteriocin, and pMG2
AID1228002	Antibacterial activity against Staphylococcus aureus isolated from tibial leg ulcer patient assessed as inhibition of visible bacterial growth incubated for 24 hrs at 37 degC by broth microdilution method	2015	Journal of natural products, Apr-24, Volume: 78, Issue:4	Antibacterial Polyketide Heterodimers from Pyrenacantha kaurabassana Tubers.
AID1890847	Selectivity index, ratio of MIC50 for antimycobacterial activity against Mycobacterium smegmatis mc2 155 harbouring pMyC::PDFMtb overexpression mutant to MIC50 for antimycobacterial activity against wild type Mycobacterium smegmatis mc2 155	2022	Bioorganic & medicinal chemistry letters, 05-15, Volume: 64	Design, synthesis and antibacterial activity against pathogenic mycobacteria of conjugated hydroxamic acids, hydrazides and O-alkyl/O-acyl protected hydroxamic derivatives.
AID164254	Antibacterial activity expressed as MIC value was determined on Pseudomonas aeruginosa A-20897 organism	1986	Journal of medicinal chemistry, May, Volume: 29, Issue:5	Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin.
AID670724	Antibacterial activity against Bacillus subtilis ATCC 530 after 24 hrs by MTT assay	2012	Bioorganic & medicinal chemistry, Jul-15, Volume: 20, Issue:14	Design, synthesis and antimicrobial activities of nitroimidazole derivatives containing 1,3,4-oxadiazole scaffold as FabH inhibitors.
AID1413340	Antifungal activity against Aspergillus niger	2018	MedChemComm, Jun-01, Volume: 9, Issue:6	Antifungal amphiphilic kanamycins: new life for an old drug.
AID1182152	Ratio of MIC99 for Mycobacterium smegmatis to ratio of MIC99 for Mycobacterium smegmatis in presence of chlorpromazine-N-oxide	2014	Bioorganic & medicinal chemistry, Aug-15, Volume: 22, Issue:16	Pharmacologically active metabolites, combination screening and target identification-driven drug repositioning in antituberculosis drug discovery.
AID1830088	Antibacterial activity against TolC deficient Escherichia coli assessed as bacterial growth inhibition measured after 16 to 20 hrs by broth dilution method
AID563509	Antimicrobial activity against cetylpyridinium chloride-sensitive Serratia marcescens 79 harboring plasmid STV29 expressing hasF gene by broth dilution method	2009	Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12	Mutational upregulation of a resistance-nodulation-cell division-type multidrug efflux pump, SdeAB, upon exposure to a biocide, cetylpyridinium chloride, and antibiotic resistance in Serratia marcescens.
AID1079939	Cirrhosis, proven histopathologically. Value is number of references indexed. [column 'CIRRH' in source]
AID1303894	Antibacterial activity against multidrug resistant Acinetobacter baumannii 2208 (ATCC 19606) assessed as reduction in bacterial growth incubated for 6 to 8 hrs	2016	Bioorganic & medicinal chemistry letters, 07-01, Volume: 26, Issue:13	GroEL/ES inhibitors as potential antibiotics.
AID1207009	Antibacterial activity against Enterococcus faecalis assessed as growth inhibition at 50 ug/disc after 24 hrs by disc diffusion method	2015	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 25, Issue:12	An antibacterial ortho-quinone diterpenoid and its derivatives from Caryopteris mongolica.
AID368424	Ratio of MIC for Escherichia coli KAM32 pSTVqepA mutant to MIC for Escherichia coli KAM32 pSTV28 mutant	2007	Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9	New plasmid-mediated fluoroquinolone efflux pump, QepA, found in an Escherichia coli clinical isolate.
AID1906418	Antibacterial activity against Pseudomonas aeruginosa ATCC 27883 assessed as reduction in microbial growth incubated for 24 hrs by microbroth dilution method	2022	European journal of medicinal chemistry, May-05, Volume: 235	Amphiphilic cyclic peptide [W
AID278548	Antimicrobial activity against 90 mins oxgall-stressed Bifidobacterium bifidum BB12 after 18 hrs	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID1593373	Inhibition of Pks13 D1644G/N1640K double mutant thioesterase domain in drug-susceptible Mycobacterium tuberculosis V4207 assessed as reduction in bacterial growth by microplate alamar blue assay	2019	Journal of medicinal chemistry, 04-11, Volume: 62, Issue:7	Identification of Novel Coumestan Derivatives as Polyketide Synthase 13 Inhibitors against Mycobacterium tuberculosis. Part II.
AID1562307	Antimycobacterial activity against Mycobacterium smegmatis atR1 assessed as decrease in drug resistance development at 5 ug/disc after 2 to 3 days by paper disc method	2019	European journal of medicinal chemistry, Sep-15, Volume: 178	Synthesis and antimycobacterial activity of imidazo[1,2-b][1,2,4,5]tetrazines.
AID424336	Antibacterial activity against fusidic acid-resistant Staphylococcus aureus AH207 harboring Thr385Asn mutation in fusA gene after 18 to 24 hrs by Etest strip assay	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID1629124	Antimicrobial activity against Haemophilus influenzae ATCC 49247 measured after 24 hrs by double-dilution method	2016	Journal of medicinal chemistry, 09-08, Volume: 59, Issue:17	Effects of 5-O-Ribosylation of Aminoglycosides on Antimicrobial Activity and Selective Perturbation of Bacterial Translation.
AID381844	Antibacterial activity against Staphylococcus aureus ATCC 6538	2008	Bioorganic & medicinal chemistry, Apr-01, Volume: 16, Issue:7	Synthesis, structure and antibacterial activity of novel 1-(5-substituted-3-substituted-4,5-dihydropyrazol-1-yl)ethanone oxime ester derivatives.
AID278231	Antimicrobial activity against Salmonella enterica serovar Typhimurium S21 tolC::Kan	2007	Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2	Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials.
AID524393	Antibacterial activity against Escherichia coli NKE1359 harboring deletion mutation in acrB protein and plasmid expressing BADnlpE gene in presence of increasing concentration of arabinose	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Effect of NlpE overproduction on multidrug resistance in Escherichia coli.
AID521599	Antibacterial activity against Salmonella enterica serovars virchow isolate 101591 assessed as log reduction in viable counts at 150 ug/ml after 1hr	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	Aminoglycosides affect intracellular Salmonella enterica serovars typhimurium and virchow.
AID1593374	Inhibition of Pks13 D1644G/N1640K double mutant thioesterase domain in multidrug-resistant Mycobacterium tuberculosis V2475 assessed as reduction in bacterial growth by microplate alamar blue assay	2019	Journal of medicinal chemistry, 04-11, Volume: 62, Issue:7	Identification of Novel Coumestan Derivatives as Polyketide Synthase 13 Inhibitors against Mycobacterium tuberculosis. Part II.
AID325449	Antibacterial activity against Staphylococcus aureus ATCC 3556 after 14 to 16 hrs by broth dilution method	2007	Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6	Polyamine effects on antibiotic susceptibility in bacteria.
AID584335	Antibacterial activity against wild type Escherichia coli BW25113 presence of 10 mM of glutathione	2010	Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12	Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics.
AID1765579	Antibacterial activity against Klebsiella pneumoniae ATCC 700603 incubated for 18 hrs by CLSI based broth dilution method	2021	Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15	Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID424344	Antibacterial activity against fusidic acid-resistant Staphylococcus aureus AH190 harboring Arg464His mutation in fusA gene after 18 to 24 hrs by Etest strip assay	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID1426250	Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 33591	2017	European journal of medicinal chemistry, Jan-27, Volume: 126	Synthesis and bioactivity investigation of quinone-based dimeric cationic triazolium amphiphiles selective against resistant fungal and bacterial pathogens.
AID1271382	Antimicrobial activity against Gram-positive methicillin-resistant Staphylococcus aureus 2 after 16 to 24 hrs by micro-dilution method	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Synthesis and Biological Activity of Mono- and Di-N-acylated Aminoglycosides.
AID725079	Antimicrobial activity against Bacillus subtilis after 12 to 18 hrs by micro-well dilution method	2013	European journal of medicinal chemistry, Jan, Volume: 59	Synthesis and antibacterial and antifungal evaluation of some chalcone based sulfones and bisulfones.
AID510559	Antibacterial activity against Escherichia coli AG102MB	2010	Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3	Single nucleotide polymorphism analysis of the major tripartite multidrug efflux pump of Escherichia coli: functional conservation in disparate animal reservoirs despite exposure to antimicrobial chemotherapy.
AID530288	Antimicrobial activity against PR-39-resistant Salmonella enterica serovar Typhimurium LT2 DA6192 by Etest	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Mechanism and fitness costs of PR-39 resistance in Salmonella enterica serovar Typhimurium LT2.
AID1132228	Antibacterial activity against drug-sensitive Escherichia coli 2482 assessed as growth inhibition by agar dilution method	1978	Journal of medicinal chemistry, Feb, Volume: 21, Issue:2	Chemical modification of 1,4-diamino-1,4-dideoxy-3-O-(4-deoxy-4-propionamido-alpha-D-glucopyranosyl)-D-glucitol.
AID1815140	Antibacterial activity against Escherichia coli ATCC25922 assessed as reduction in bacterial growth	2021	European journal of medicinal chemistry, Dec-15, Volume: 226	Synthesis and biological evaluation of indole-based peptidomimetics as antibacterial agents against Gram-positive bacteria.
AID424605	Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH362 (SCV-34) harboring TAA stop codon at nucleotide 282 in rplF gene after 18 to 24 hrs by Etest strip assay	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID1265785	Antibacterial activity against Bacillus subtilis 168 by microdilution method	2015	Journal of medicinal chemistry, Dec-10, Volume: 58, Issue:23	Synthesis and Bioactivities of Kanamycin B-Derived Cationic Amphiphiles.
AID449435	Antimycobacterial activity against Mycobacterium tuberculosis XDR infected in MDBK by BACTEC analysis	2009	European journal of medicinal chemistry, Nov, Volume: 44, Issue:11	Pentacyclo-undecane derived cyclic tetra-amines: synthesis and evaluation as potent anti-tuberculosis agents.
AID1887298	Antibacterial activity against Staphylococcus epidermidis ATCC 51625 assessed as inhibition of bacterial growth incubated for 24 hrs by optical density based analysis	2022	Journal of natural products, 09-23, Volume: 85, Issue:9	Total Syntheses and Antibacterial Evaluations of Neocyclomorusin and Related Flavones.
AID278539	Antimicrobial activity against 60 min 1 M HCl-stressed Bifidobacterium infantis ATCC 15697 after 18 hrs	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID1565708	Antifungal activity against azole-susceptible Candida albicans MYA2876 incubated for 24 to 36 hrs by two fold dilution method	2019	European journal of medicinal chemistry, Nov-15, Volume: 182	Scalable and cost-effective tosylation-mediated synthesis of antifungal and fungal diagnostic 6″-Modified amphiphilic kanamycins.
AID278803	Antimicrobial activity against recombinant Escherichia coli DHalpha expressing pBAD [aph(3')-2]	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Aph(3')-IIc, an aminoglycoside resistance determinant from Stenotrophomonas maltophilia.
AID569261	Antimicrobial activity against methicillin-resistant Staphylococcus aureus 873	2011	Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3	Synthesis and evaluation of anti-tubercular activity of new dithiocarbamate sugar derivatives.
AID587758	Antimicrobial activity against wild type Mycobacterium ulcerans ATCC 19423 infected BALB/c mouse assessed as reduction in foodpad CFU count after 4 weeks	2011	Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1	Using bioluminescence to monitor treatment response in real time in mice with Mycobacterium ulcerans infection.
AID424596	Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH358 (SCV-30) harboring -1 frameshift mutation at nucleotide 423 in rplF gene after 18 to 24 hrs by Etest strip assay	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID1299580	Antibacterial activity against Pseudomonas aeruginosa PAO1 ATCC 47085 incubated overnight by microbroth dilution method	2016	Journal of medicinal chemistry, Apr-14, Volume: 59, Issue:7	Antibacterial Diamines Targeting Bacterial Membranes.
AID278540	Antimicrobial activity against 60 min 1 M HCl-stressed Bifidobacterium longum ATCC 15707 after 18 hrs	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID1617940	Antibacterial activity against Staphylococcus aureus ATCC 6538 after 16 to 48 hrs	2019	Journal of natural products, 12-27, Volume: 82, Issue:12	Structure Determination, Functional Characterization, and Biosynthetic Implications of Nybomycin Metabolites from a Mining Reclamation Site-Associated
AID1303883	Antibacterial activity against methicillin resistant Staphylococcus aureus subsp. aureus HPV107 (ATCC BAA-44) assessed as reduction in bacterial growth incubated for 6 to 8 hrs	2016	Bioorganic & medicinal chemistry letters, 07-01, Volume: 26, Issue:13	GroEL/ES inhibitors as potential antibiotics.
AID278804	Antimicrobial activity against recombinant Escherichia coli DH5-alpha expressing pBAD [aph(3')-2] in the presence of arabinose	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Aph(3')-IIc, an aminoglycoside resistance determinant from Stenotrophomonas maltophilia.
AID283543	Antibacterial activity against Pseudomonas aeruginosa FE57UZ with inactivated rplY, galU and mexZ genes by microdilution method	2007	Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3	Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides.
AID326553	Antimicrobial activity against Mycobacterium fortuitum V146 isolate after 3 to 5 days by broth microdilution method	2007	Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5	In Vitro activities of isepamicin, other aminoglycosides, and capreomycin against clinical isolates of rapidly growing mycobacteria in Taiwan.
AID1869560	Bactericidal activity against Mycobacterium phlei DSM 43239 assessed as reduction in colony count and measured after 3 days by agar diffusion assay	2022	Journal of natural products, 06-24, Volume: 85, Issue:6	Triculamin: An Unusual Lasso Peptide with Potent Antimycobacterial Activity.
AID278256	Antimicrobial activity against Salmonella enterica serovar Typhimurium CS9 with GyrA S83F, D87N, ParC S80I mutation	2007	Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2	Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials.
AID625289	Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver disease	2011	PLoS computational biology, Dec, Volume: 7, Issue:12	Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID521591	Antibacterial activity against Salmonella enterica serovars Typhimurium ATCC 14028 at pH 5.7 by broth dilution method	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	Aminoglycosides affect intracellular Salmonella enterica serovars typhimurium and virchow.
AID1868098	Antibacterial activity against Staphylococcus epidermidis ATCC 12228 assessed as inhibition of visible bacterial growth incubated for 18 hrs by CLSI protocol based assay	2022	Journal of natural products, 05-27, Volume: 85, Issue:5	Enceleamycins A-C, Furo-Naphthoquinones from
AID1105398	Antibacterial activity against Pseudomonas aeruginosa MTCC 2581 assessed as growth inhibition at 25 ug/disk after 24 hr by disk diffusion method	2013	European journal of medicinal chemistry, Jan, Volume: 59	Microwave synthesis, characterization and bio-efficacy evaluation of novel chalcone based 6-carbethoxy-2-cyclohexen-1-one and 2H-indazol-3-ol derivatives.
AID30415	Minimum inhibitory concentration (MIC) was measured against Acinetobacter lwoffi ATCC 17986.	1995	Journal of medicinal chemistry, Nov-10, Volume: 38, Issue:23	Synthesis and antimicrobial and toxicological studies of amino acid and peptide derivatives of kanamycin A and netilmicin.
AID760037	Antibacterial activity against Burkholderia thailandensis E264 assessed as bacterial growth inhibition at 0.5 mM after 24 hrs by two-fold dilution method relative to control	2013	ACS medicinal chemistry letters, Jul-01, Volume: 4, Issue:8	Discovery of Inhibitors of
AID1176778	Antimicrobial activity against Saccharomyces cerevisiae BY4741 after 24 hrs by broth microdilution method	2015	Journal of natural products, Jan-23, Volume: 78, Issue:1	Structure and antimicrobial activity of phloroglucinol derivatives from Achyrocline satureioides.
AID95884	Antibacterial activity expressed as MIC value was determined on Klebsiella pneumonia A-20468 organism	1986	Journal of medicinal chemistry, May, Volume: 29, Issue:5	Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin.
AID278250	Antimicrobial activity against Salmonella enterica serovar Typhimurium CS1 acrAB::Kan with GyrA S83F, D87N, ParC S80I mutation	2007	Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2	Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials.
AID556562	Antimicrobial activity against sodA gene-deficient Escherichia coli K-12 3144 by broth dilution method	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	Contribution of oxidative damage to antimicrobial lethality.
AID1585461	Antibacterial activity against erythromycin-resistant Staphylococcus aureus NRS-70 measured after 16 hrs	2019	European journal of medicinal chemistry, Jan-15, Volume: 162	Design, synthesis and evaluation of hybrid of tetrahydrocarbazole with 2,4-diaminopyrimidine scaffold as antibacterial agents.
AID523405	Antimicrobial activity against amikacin-susceptible Nocardia farcinica IFM 10152 after 3 days by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6	Homozygous triplicate mutations in three 16S rRNA genes responsible for high-level aminoglycoside resistance in Nocardia farcinica clinical isolates from a Canada-wide bovine mastitis epizootic.
AID563503	Antimicrobial activity against cetylpyridinium chloride-sensitive Serratia marcescens 79 by broth dilution method	2009	Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12	Mutational upregulation of a resistance-nodulation-cell division-type multidrug efflux pump, SdeAB, upon exposure to a biocide, cetylpyridinium chloride, and antibiotic resistance in Serratia marcescens.
AID625280	Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cholecystitis	2011	PLoS computational biology, Dec, Volume: 7, Issue:12	Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID1079941	Liver damage due to vascular disease: peliosis hepatitis, hepatic veno-occlusive disease, Budd-Chiari syndrome. Value is number of references indexed. [column 'VASC' in source]
AID771495	Antibacterial activity against Pseudomonas aeruginosa by dilution technique	2013	European journal of medicinal chemistry, Oct, Volume: 68	Synthesis and biological evaluation of novel ocotillol-type triterpenoid derivatives as antibacterial agents.
AID1250525	Antibacterial activity against Pseudomonas aeruginosa ATCC 9027 after 24 hr by MTT assay	2015	European journal of medicinal chemistry, Sep-18, Volume: 102	Synthesis and evaluation of new tyrosyl-tRNA synthetase inhibitors as antibacterial agents based on a N2-(arylacetyl)glycinanilide scaffold.
AID424589	Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH370 (SCV-42) harboring TAA stop codon at nucleotide 229 in rplF gene after 18 to 24 hrs by Etest strip assay	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID164253	Antibacterial activity expressed as MIC value was determined on Pseudomonas aeruginosa A-20741 organism	1986	Journal of medicinal chemistry, May, Volume: 29, Issue:5	Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin.
AID424335	Antibacterial activity against fusidic acid-susceptible wild type Staphylococcus aureus 8325-4 after 18 to 24 hrs by Etest strip assay	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID490134	Antibacterial activity against Bacillus subtilis ATCC 6633 after 24 hrs by MTT assay	2010	European journal of medicinal chemistry, Jul, Volume: 45, Issue:7	Synthesis of some N-alkyl substituted urea derivatives as antibacterial and antifungal agents.
AID278805	Antimicrobial activity against Stenotrophomonas maltophilia K279a mutant	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Aph(3')-IIc, an aminoglycoside resistance determinant from Stenotrophomonas maltophilia.
AID68018	Antibacterial activity expressed as MIC value was determined on Enterobacter cloacae A-9656 organism	1986	Journal of medicinal chemistry, May, Volume: 29, Issue:5	Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin.
AID424611	Antibacterial activity against kanamycin-resistant and fusidic acid-susceptible Staphylococcus aureus AH288 harboring Gly617Asp mutation in fusA gene after 18 to 24 hrs by Etest strip assay	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID1695859	Antibacterial activity against Staphylococcus aureus ATCC 29737 incubated for 24 hrs	2019	European journal of medicinal chemistry, Apr-15, Volume: 168	Comprehensive review on the anti-bacterial activity of 1,2,3-triazole hybrids.
AID520869	Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus saprophyticus isolate TSU33 isolated from genitourinary tracts of acute cystitis patient after 24 hrs at 35 degC by agar dilution method	2008	Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6	Methicillin-resistant Staphylococcus saprophyticus isolates carrying staphylococcal cassette chromosome mec have emerged in urogenital tract infections.
AID524389	Antibacterial activity against Escherichia coli NKE1367 harboring deletion mutation in acrB, mdtABC protein and plasmid expressing nlpE gene	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Effect of NlpE overproduction on multidrug resistance in Escherichia coli.
AID1432500	Antibacterial activity against Bacillus subtilis NBRC 3134 after overnight incubation by MTT assay	2017	Bioorganic & medicinal chemistry letters, 03-15, Volume: 27, Issue:6	Filamenting temperature-sensitive mutant Z inhibitors from Glycyrrhiza glabra and their inhibitory mode of action.
AID1265790	Antibacterial activity against Staphylococcus aureus NRS382 (USA 100) by microdilution method	2015	Journal of medicinal chemistry, Dec-10, Volume: 58, Issue:23	Synthesis and Bioactivities of Kanamycin B-Derived Cationic Amphiphiles.
AID325444	Antibacterial activity against Escherichia coli K12 after 14 to 16 hrs by broth dilution method	2007	Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6	Polyamine effects on antibiotic susceptibility in bacteria.
AID428869	Antibacterial activity against Escherichia coli isolate ARS3 carrying pARS3 by agar dilution method	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Novel plasmid-mediated 16S rRNA m1A1408 methyltransferase, NpmA, found in a clinically isolated Escherichia coli strain resistant to structurally diverse aminoglycosides.
AID544273	Antimicrobial activity against Enterococcus faecalis NKH3 harboring pMG2200-like and pMG2201-like plasmids after 24 hrs by agar dilution method	2009	Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2	Isolation of VanB-type Enterococcus faecalis strains from nosocomial infections: first report of the isolation and identification of the pheromone-responsive plasmids pMG2200, Encoding VanB-type vancomycin resistance and a Bac41-type bacteriocin, and pMG2
AID1493076	Antibacterial activity against vancomycin-resistant Enterococcus faecium 7 by dilution susceptibility test	2017	Journal of natural products, 11-22, Volume: 80, Issue:11	Antibacterial 3,6-Disubstituted 4-Hydroxy-5,6-dihydro-2H-pyran-2-ones from Serratia plymuthica MF371-2.
AID1413333	Antifungal activity against Candida albicans B-311	2018	MedChemComm, Jun-01, Volume: 9, Issue:6	Antifungal amphiphilic kanamycins: new life for an old drug.
AID164371	Antibacterial activity expressed as MIC value was determined on Pseudomonas aeruginosa A-22233 organism	1986	Journal of medicinal chemistry, May, Volume: 29, Issue:5	Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin.
AID368423	Antimicrobial activity against Escherichia coli KAM32 pSTVdeltaqepA containing disrupted qepA gene by agar dilution method	2007	Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9	New plasmid-mediated fluoroquinolone efflux pump, QepA, found in an Escherichia coli clinical isolate.
AID535769	Antimicrobial activity against Mycobacterium ulcerans ATCC 19423 agar dilution method	2010	Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7	Rapid assessment of antibacterial activity against Mycobacterium ulcerans by using recombinant luminescent strains.
AID523396	Antimicrobial activity against amikacin-resistant Nocardia farcinica IFM 10580 after 3 days by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6	Homozygous triplicate mutations in three 16S rRNA genes responsible for high-level aminoglycoside resistance in Nocardia farcinica clinical isolates from a Canada-wide bovine mastitis epizootic.
AID574803	Antimycobacterial activity against extensively drug-resistant Mycobacterium tuberculosis isolate 2474 obtained from sputum of patient at 4 ug/ml by Bactec MGIT960 modified proportion method	2010	Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11	Emergence and molecular characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates from the Delhi Region in India.
AID510749	Antibacterial activity against Escherichia coli AG102MB harboring pP10-based acrB gene	2010	Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3	Single nucleotide polymorphism analysis of the major tripartite multidrug efflux pump of Escherichia coli: functional conservation in disparate animal reservoirs despite exposure to antimicrobial chemotherapy.
AID1562312	Antimycobacterial activity against Mycobacterium smegmatis atR14 assessed as decrease in drug resistance development at 5 ug/disc after 2 to 3 days by paper disc method	2019	European journal of medicinal chemistry, Sep-15, Volume: 178	Synthesis and antimycobacterial activity of imidazo[1,2-b][1,2,4,5]tetrazines.
AID424572	Antibacterial activity against kanamycin-susceptible wild type Staphylococcus aureus AH001 after 18 to 24 hrs by Etest strip assay	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID290123	Inhibition of protein synthesis in Escherichia coli by coupled transcription-translation assay	2007	Bioorganic & medicinal chemistry letters, Mar-01, Volume: 17, Issue:5	Synthesis and SAR of 3,5-diamino-piperidine derivatives: novel antibacterial translation inhibitors as aminoglycoside mimetics.
AID619545	Antibacterial activity against Bacillus subtilis ATCC 6633 after 24 hrs by MTT assay	2011	European journal of medicinal chemistry, Oct, Volume: 46, Issue:10	Tyrosyl-tRNA synthetase inhibitors as antibacterial agents: synthesis, molecular docking and structure-activity relationship analysis of 3-aryl-4-arylaminofuran-2(5H)-ones.
AID556566	Antimicrobial activity against ahpC gene-deficient Escherichia coli K-12 3200 by broth dilution method	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	Contribution of oxidative damage to antimicrobial lethality.
AID534339	Antimicrobial activity against Burkholderia pseudomallei 1026b after 24 hrs by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8	The BpeAB-OprB efflux pump of Burkholderia pseudomallei 1026b does not play a role in quorum sensing, virulence factor production, or extrusion of aminoglycosides but is a broad-spectrum drug efflux system.
AID574807	Antimycobacterial activity against extensively drug-resistant Mycobacterium tuberculosis isolate 761 horboring rpoB S531L/Q510P, katG S315T/R463L, gyrA D94N/S95T, rrs G1484T by CLSI method	2010	Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11	Emergence and molecular characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates from the Delhi Region in India.
AID1566490	Inhibition of Dicer mediated biotinylated pre-miRNA-21 (unknown origin) maturation at 1 mM measured after 15 mins by cat-ELCCA relative to control	2019	ACS medicinal chemistry letters, May-09, Volume: 10, Issue:5	Tetracyclines as Inhibitors of Pre-microRNA Maturation: A Disconnection between RNA Binding and Inhibition.
AID625925	Antibacterial activity against Pseudomonas aeruginosa by micro-broth dilution method	2011	Bioorganic & medicinal chemistry letters, Nov-01, Volume: 21, Issue:21	Micelles catalyzed chemoselective synthesis 'in water' and biological evaluation of oxygen containing hetero-1,4-naphthoquinones as potential antifungal agents.
AID1852754	Antibacterial activity against wild type Escherichia coli ATCC 25922 assessed as bacterial growth inhibition by broth microdilution assay	2022	RSC medicinal chemistry, Sep-21, Volume: 13, Issue:9	Design and evaluation of poly-nitrogenous adjuvants capable of potentiating antibiotics in Gram-negative bacteria.
AID1738320	Antibacterial activity against multidrug-resistant Staphylococcus aureus NRS1 assessed as reduction in bacterial growth incubated for 16 to 18 hrs by two fold serial dilution method	2020	European journal of medicinal chemistry, Jul-15, Volume: 198	Capsaicin derivatives with nitrothiophene substituents: Design, synthesis and antibacterial activity against multidrug-resistant S. aureus.
AID521582	Antibacterial activity against Salmonella enterica serovars Typhimurium ATCC 14028 infected in mouse J774A.1 cells at 50 ug/ml after 1hr	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	Aminoglycosides affect intracellular Salmonella enterica serovars typhimurium and virchow.
AID283533	Antibacterial activity against Pseudomonas aeruginosa FE57 with inactivated rplY gene by microdilution method	2007	Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3	Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides.
AID69758	Antibacterial activity expressed as MIC value was determined on Escherichia coli A-22356 organism	1986	Journal of medicinal chemistry, May, Volume: 29, Issue:5	Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin.
AID428871	Antibacterial activity against Escherichia coli CSH-2 by agar dilution method	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Novel plasmid-mediated 16S rRNA m1A1408 methyltransferase, NpmA, found in a clinically isolated Escherichia coli strain resistant to structurally diverse aminoglycosides.
AID1164940	Antimicrobial activity against Mycobacterium tuberculosis H37Rv by microbroth dilution method	2014	Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20	Synthesis, structure-activity relationship studies, and antibacterial evaluation of 4-chromanones and chalcones, as well as olympicin A and derivatives.
AID1562309	Antimycobacterial activity against Mycobacterium smegmatis atR11 assessed as decrease in drug resistance development at 5 ug/disc after 2 to 3 days by paper disc method	2019	European journal of medicinal chemistry, Sep-15, Volume: 178	Synthesis and antimycobacterial activity of imidazo[1,2-b][1,2,4,5]tetrazines.
AID524392	Antibacterial activity against Escherichia coli NKE1369 harboring deletion mutation in acrB, acrD, mdtABC protein and plasmid expressing nlpE gene	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Effect of NlpE overproduction on multidrug resistance in Escherichia coli.
AID1765577	Antibacterial activity against Escherichia coli ATCC 25922 incubated for 18 hrs by CLSI based broth dilution method	2021	Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15	Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID584326	Antibacterial activity against tolC deficient Escherichia coli GD100	2010	Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12	Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics.
AID257553	Antibacterial activity against Pseudomonas aeruginosa	2005	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 15, Issue:23	Synthesis and biological evaluation of novel (L)-alpha-amino acid methyl ester, heteroalkyl, and aryl substituted 1,4-naphthoquinone derivatives as antifungal and antibacterial agents.
AID1638885	Antimicrobial activity against Bacillus subtilis at 0.5 to 256 ug/ml after 24 hrs by two-fold serial micro dilution method	2019	Journal of natural products, 04-26, Volume: 82, Issue:4	Inducing Secondary Metabolite Production by Co-culture of the Endophytic Fungus Phoma sp. and the Symbiotic Fungus Armillaria sp.
AID424612	Antibacterial activity against kanamycin-resistant and fusidic acid-susceptible Staphylococcus aureus AH294 harboring Gly628Val mutation in fusA gene after 18 to 24 hrs by Etest strip assay	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID278243	Antimicrobial activity against Salmonella enterica serovar Typhimurium S21-3 tolC::Kan with GyrA S83F, ParC S80I mutation	2007	Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2	Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials.
AID420209	Antimicrobial activity against Serratia marcescens UFPEDA 398 at 30 ug/disk after 24 hrs by disk diffusion method	2009	European journal of medicinal chemistry, May, Volume: 44, Issue:5	Synthesis, antimicrobial and cytotoxic activities of some 5-arylidene-4-thioxo-thiazolidine-2-ones.
AID565418	Antimicrobial activity against Salmonella enterica serotype Stanley isolate AM04864 expressing armA rRNA methyltransferase gene by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	Identification of the aminoglycoside resistance determinants armA and rmtC among non-Typhi Salmonella isolates from humans in the United States.
AID1293901	Antibacterial activity against Bacillus subtilis after 18 hrs by broth dilution method	2016	Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9	Novel tetrazoloquinoline-rhodanine conjugates: Highly efficient synthesis and biological evaluation.
AID470061	Antibacterial activity against Mycobacterium smegmatis after 3 days by broth microdilution method	2009	Journal of natural products, Nov, Volume: 72, Issue:11	Bioactive constituents of the stem bark of Mitrephora glabra.
AID1132236	Antibacterial activity against drug-sensitive Proteus vulgaris 838 assessed as growth inhibition by agar dilution method	1978	Journal of medicinal chemistry, Feb, Volume: 21, Issue:2	Chemical modification of 1,4-diamino-1,4-dideoxy-3-O-(4-deoxy-4-propionamido-alpha-D-glucopyranosyl)-D-glucitol.
AID1593377	Inhibition of Pks13 D1644G/N1640K double mutant thioesterase domain in extensively drug-resistant Mycobacterium tuberculosis R506 assessed as reduction in bacterial growth by microplate alamar blue assay	2019	Journal of medicinal chemistry, 04-11, Volume: 62, Issue:7	Identification of Novel Coumestan Derivatives as Polyketide Synthase 13 Inhibitors against Mycobacterium tuberculosis. Part II.
AID584337	Antibacterial activity against tolC deficient Escherichia coli GD100 absence of glutathione	2010	Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12	Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics.
AID718270	Antimicrobial activity against Escherichia coli ATCC 25922	2012	Journal of natural products, Dec-28, Volume: 75, Issue:12	Marthiapeptide A, an anti-infective and cytotoxic polythiazole cyclopeptide from a 60 L scale fermentation of the deep sea-derived Marinactinospora thermotolerans SCSIO 00652.
AID1132224	Antibacterial activity against streptomycin, neomycin, kanamycin-resistant Staphylococcus aureus 2314 assessed as growth inhibition by agar dilution method	1978	Journal of medicinal chemistry, Feb, Volume: 21, Issue:2	Chemical modification of 1,4-diamino-1,4-dideoxy-3-O-(4-deoxy-4-propionamido-alpha-D-glucopyranosyl)-D-glucitol.
AID425072	Antimicrobial activity against Escherichia coli DH10B expressing pCRQB10 in presence of IPTG	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Complex class 1 integrons with diverse variable regions, including aac(6')-Ib-cr, and a novel allele, qnrB10, associated with ISCR1 in clinical enterobacterial isolates from Argentina.
AID1510726	Antibacterial activity against Escherichia coli	2019	European journal of medicinal chemistry, Oct-01, Volume: 179	Nitroimidazole-containing compounds and their antibacterial and antitubercular activities.
AID424832	Ratio of MIC for kanamycin-resistant Staphylococcus aureus harboring mutations in FusE gene to MIC for wild type kanamycin-susceptible Staphylococcus aureus AH001	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID1079949	Proposed mechanism(s) of liver damage. [column 'MEC' in source]
AID424600	Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH384 (SCV-56) harboring -1 frameshift mutation at nucleotide 221 in rplF gene after 18 to 24 hrs by Etest strip assay	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID285339	Antimicrobial activity against streptomycin-resistant Escherichia coli J53 by agar dilution method	2007	Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4	First report of plasmid-mediated qnrA1 in a ciprofloxacin-resistant Escherichia coli strain in Latin America.
AID1478523	Antibacterial activity against aminoglycosides-susceptible Escherichia coli R477-100 by double microdilution method	2017	Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11	Covalently linked kanamycin - Ciprofloxacin hybrid antibiotics as a tool to fight bacterial resistance.
AID1593386	Growth inhibition of Escherichia coli AB1157	2019	Journal of medicinal chemistry, 04-11, Volume: 62, Issue:7	Identification of Novel Coumestan Derivatives as Polyketide Synthase 13 Inhibitors against Mycobacterium tuberculosis. Part II.
AID521595	Antibacterial activity against Salmonella enterica serovars virchow isolate 101591 at pH 7.0 by bioluminescence assay	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	Aminoglycosides affect intracellular Salmonella enterica serovars typhimurium and virchow.
AID278534	Antimicrobial activity against 60 min 1 M HCl-stressed Bifidobacterium animalis ATCC 27536 after 18 hrs	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID290146	Antibacterial activity against Pseudomonas fluorescens after 24 hrs by MTT colorimetric method	2007	European journal of medicinal chemistry, Apr, Volume: 42, Issue:4	Synthesis and antimicrobial activities of Schiff bases derived from 5-chloro-salicylaldehyde.
AID1887297	Antibacterial activity against Staphylococcus aureus ATCC 25923 assessed as inhibition of bacterial growth incubated for 24 hrs by optical density based analysis	2022	Journal of natural products, 09-23, Volume: 85, Issue:9	Total Syntheses and Antibacterial Evaluations of Neocyclomorusin and Related Flavones.
AID424606	Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH330 (SCV-2) harboring -1 frameshift mutation at nucleotide 423 in rplF gene after 18 to 24 hrs by Etest strip assay	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID486726	Antibacterial activity against Pseudomonas fluorescens ATCC 13525 after 24 hrs by MTT assay	2010	European journal of medicinal chemistry, Jun, Volume: 45, Issue:6	Synthesis, structure and structure-activity relationship analysis of caffeic acid amides as potential antimicrobials.
AID278529	Antimicrobial activity against Bifidobacterium longum R0175	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID1265788	Antibacterial activity against Mycobacterium smegmatis MC2 155 by microdilution method	2015	Journal of medicinal chemistry, Dec-10, Volume: 58, Issue:23	Synthesis and Bioactivities of Kanamycin B-Derived Cationic Amphiphiles.
AID1413325	Antifungal activity against Cryptococcus neoformans 94-2586	2018	MedChemComm, Jun-01, Volume: 9, Issue:6	Antifungal amphiphilic kanamycins: new life for an old drug.
AID1176777	Antimicrobial activity against Enterococcus faecalis ATCC 29212 after 24 hrs by broth microdilution method	2015	Journal of natural products, Jan-23, Volume: 78, Issue:1	Structure and antimicrobial activity of phloroglucinol derivatives from Achyrocline satureioides.
AID1557267	Antitubercular activity against resistant Mycobacterium tuberculosis harboring rrs G37T mutant after 3 to 6 weeks	2019	MedChemComm, Aug-01, Volume: 10, Issue:8	Drug-resistance in
AID540932	Antimicrobial activity against paromomycin-resistant Streptomyces coelicolor SP2 harboring rpsL K88E mutant gene and inserted glycine at position 92 of the gene after 48 hrs	2009	Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3	A novel insertion mutation in Streptomyces coelicolor ribosomal S12 protein results in paromomycin resistance and antibiotic overproduction.
AID584116	Ratio of MIC for Escherichia coli KAM32 harboring cloned pSP72 lmrS to MIC for Escherichia coli KAM32 harboring pSP72	2010	Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12	LmrS is a multidrug efflux pump of the major facilitator superfamily from Staphylococcus aureus.
AID534346	Antimicrobial activity against Burkholderia pseudomallei Bp207 harboring deleted (bpeAB-oprA)::FRT gene after 24 hrs by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8	The BpeAB-OprB efflux pump of Burkholderia pseudomallei 1026b does not play a role in quorum sensing, virulence factor production, or extrusion of aminoglycosides but is a broad-spectrum drug efflux system.
AID532982	Antibacterial activity against Escherichia coli W3110 in presence of 10 mM N-Acetylcysteine	2010	Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8	N-acetylcysteine-mediated modulation of bacterial antibiotic susceptibility.
AID1510727	Antibacterial activity against Pseudomonas aeruginosa	2019	European journal of medicinal chemistry, Oct-01, Volume: 179	Nitroimidazole-containing compounds and their antibacterial and antitubercular activities.
AID278532	Antimicrobial activity against Bifidobacterium thermophilum ATCC 25866	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID1565714	Antifungal activity against Cryptococcus neoformans VR-54 incubated for 24 to 36 hrs by two fold dilution method	2019	European journal of medicinal chemistry, Nov-15, Volume: 182	Scalable and cost-effective tosylation-mediated synthesis of antifungal and fungal diagnostic 6″-Modified amphiphilic kanamycins.
AID278551	Antimicrobial activity against 90 mins oxgall-stressed Bifidobacterium infantis ATCC 15697 after 18 hrs	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID424340	Antibacterial activity against fusidic acid-resistant Staphylococcus aureus AH201 harboring Gly452Cys mutation in fusA after 18 to 24 hrs by Etest strip assay	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID1337844	Antifungal activity against Aspergillus flavus NCIM 539 by standard agar method	2017	European journal of medicinal chemistry, Jan-05, Volume: 125	Quinolidene-rhodanine conjugates: Facile synthesis and biological evaluation.
AID1510725	Antibacterial activity against Bacillus subtilis	2019	European journal of medicinal chemistry, Oct-01, Volume: 179	Nitroimidazole-containing compounds and their antibacterial and antitubercular activities.
AID1478544	Antibacterial activity against Bacillus subtilis ATCC 6633 in 15th subculture in presence of equimolar concentration of ciprofloxacin by double microdilution method	2017	Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11	Covalently linked kanamycin - Ciprofloxacin hybrid antibiotics as a tool to fight bacterial resistance.
AID374112	Antimicrobial activity against azide-resistant aac(6')-Ib-cr expressing Escherichia coli J53 qnrA1 bearing pHS6 transconjugant from Escherichia coli 650 by agar dilution method	2007	Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11	Prevalence and expression of the plasmid-mediated quinolone resistance determinant qnrA1.
AID424339	Antibacterial activity against fusidic acid-resistant Staphylococcus aureus AH198 harboring Gly452Ser mutation in fusA gene after 18 to 24 hrs by Etest strip assay	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID1132225	Antibacterial activity against drug-sensitive Bacillus subtilis 964 assessed as growth inhibition by agar dilution method	1978	Journal of medicinal chemistry, Feb, Volume: 21, Issue:2	Chemical modification of 1,4-diamino-1,4-dideoxy-3-O-(4-deoxy-4-propionamido-alpha-D-glucopyranosyl)-D-glucitol.
AID1868109	Antibacterial activity against Pseudomonas aeruginosa ATCC 9027 assessed as inhibition of visible bacterial growth incubated for 18 hrs by CLSI protocol based assay	2022	Journal of natural products, 05-27, Volume: 85, Issue:5	Enceleamycins A-C, Furo-Naphthoquinones from
AID774297	Antimycobacterial activity against isoniazid-resistant Mycobacterium tuberculosis ATCC 35822	2013	Journal of natural products, Oct-25, Volume: 76, Issue:10	Chlorinated coumarins from the polypore mushroom Fomitopsis officinalis and their activity against Mycobacterium tuberculosis.
AID364063	Antibacterial activity against Pseudomonas fluorescens ATCC 13525 after 24 hrs by MTT assay	2008	European journal of medicinal chemistry, Sep, Volume: 43, Issue:9	Enamines as novel antibacterials and their structure-activity relationships.
AID560598	Antimicrobial activity against Escherichia coli JM109 transformant harboring pSTV28 plasmid by microdilution method	2009	Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6	AAC(6')-Iaf, a novel aminoglycoside 6'-N-acetyltransferase from multidrug-resistant Pseudomonas aeruginosa clinical isolates.
AID278249	Antimicrobial activity against Salmonella enterica serovar Typhimurium CS1 gyrA+ with GyrA S83F, D87N, ParC S80I mutation	2007	Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2	Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials.
AID1413321	Antibacterial activity against Escherichia coli TG1	2018	MedChemComm, Jun-01, Volume: 9, Issue:6	Antifungal amphiphilic kanamycins: new life for an old drug.
AID1265792	Antibacterial activity against Staphylococcus aureus NRS385 (USA 300) by microdilution method	2015	Journal of medicinal chemistry, Dec-10, Volume: 58, Issue:23	Synthesis and Bioactivities of Kanamycin B-Derived Cationic Amphiphiles.
AID1413315	Antifungal activity against Cryptococcus neoformans 90-26	2018	MedChemComm, Jun-01, Volume: 9, Issue:6	Antifungal amphiphilic kanamycins: new life for an old drug.
AID524383	Antibacterial activity against Escherichia coli NKE161 harboring deletion mutation in acrB protein, vector expressing tolC gene and plasmid expressing nlpE gene	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Effect of NlpE overproduction on multidrug resistance in Escherichia coli.
AID69757	Antibacterial activity expressed as MIC value was determined on Escherichia coli A-9632 organism	1986	Journal of medicinal chemistry, May, Volume: 29, Issue:5	Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin.
AID1228001	Antibacterial activity against Staphylococcus aureus isolated from tibial osteomyelitis patient assessed as inhibition of visible bacterial growth incubated for 24 hrs at 37 degC by broth microdilution method	2015	Journal of natural products, Apr-24, Volume: 78, Issue:4	Antibacterial Polyketide Heterodimers from Pyrenacantha kaurabassana Tubers.
AID1132239	Antibacterial activity against drug-sensitive Escherichia coli 60 assessed as growth inhibition by agar dilution method	1978	Journal of medicinal chemistry, Feb, Volume: 21, Issue:2	Chemical modification of 1,4-diamino-1,4-dideoxy-3-O-(4-deoxy-4-propionamido-alpha-D-glucopyranosyl)-D-glucitol.
AID1852779	Antimycobacterial activity against Mycobacterium tuberculosis H37Rv assessed as inhibition of bacterial growth for 5 weeks by spot culture growth inhibition assay	2022	RSC medicinal chemistry, Nov-16, Volume: 13, Issue:11	Synthesis, biological evaluation and computational studies of pyrazole derivatives as
AID278522	Antimicrobial activity against Bifidobacterium bifidum R0071	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID69629	Minimum inhibitory concentration was measured against Escherichia coli A 20665	1980	Journal of medicinal chemistry, Jan, Volume: 23, Issue:1	Aminoglycoside antibiotics. 3. Epimino derivatives of neamine, ribostamycin, and kanamycin B.
AID1455939	Antifungal activity against Trichophyton mentagrophytes after 96 hrs by broth micro-dilution method	2017	Journal of natural products, 02-24, Volume: 80, Issue:2	Nabscessins A and B, Aminocyclitol Derivatives from Nocardia abscessus IFM 10029
AID278566	Antimicrobial activity against 90 mins hydrogen peroxide-stressed Bifidobacterium longum P/N 601377 after 18 hrs	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID584115	Antibacterial activity against Escherichia coli KAM32 harboring pSP72 by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12	LmrS is a multidrug efflux pump of the major facilitator superfamily from Staphylococcus aureus.
AID275055	Antibacterial activity against Escherichia coli pTMV19	2006	Journal of medicinal chemistry, Dec-14, Volume: 49, Issue:25	Isoprenoid biosynthesis as a drug target: bisphosphonate inhibition of Escherichia coli K12 growth and synergistic effects of fosmidomycin.
AID551745	Antibacterial activity against Escherichia coli ATCC 25922 after 12 to 18 hrs by twofold dilution method	2011	Bioorganic & medicinal chemistry, Jan-01, Volume: 19, Issue:1	Synthesis and antibacterial activity study of a novel class of cationic anthraquinone analogs.
AID69753	Antibacterial activity expressed as MIC value was determined on Escherichia coli A-20895 organism	1986	Journal of medicinal chemistry, May, Volume: 29, Issue:5	Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin.
AID749378	Antimicrobial activity against Escherichia coli ATCC 25922 after 24 hrs by two fold serial dilution method	2013	Bioorganic & medicinal chemistry, Jun-01, Volume: 21, Issue:11	Design, synthesis and antimicrobial activities evaluation of Schiff base derived from secnidazole derivatives as potential FabH inhibitors.
AID163265	Minimum inhibitory concentration was measured against Pseudomonas aeruginosa A 20653	1980	Journal of medicinal chemistry, Jan, Volume: 23, Issue:1	Aminoglycoside antibiotics. 3. Epimino derivatives of neamine, ribostamycin, and kanamycin B.
AID278251	Antimicrobial activity against Salmonella enterica serovar Typhimurium CS1 tolC::Kan with GyrA S83F, D87N, ParC S80I mutation	2007	Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2	Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials.
AID381843	Antibacterial activity against Pseudomonas fluorescens ATCC 13525	2008	Bioorganic & medicinal chemistry, Apr-01, Volume: 16, Issue:7	Synthesis, structure and antibacterial activity of novel 1-(5-substituted-3-substituted-4,5-dihydropyrazol-1-yl)ethanone oxime ester derivatives.
AID424338	Antibacterial activity against fusidic acid-resistant Staphylococcus aureus AH196 harboring Pro406Leu mutation in fusA gene after 18 to 24 hrs by Etest strip assay	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID283539	Antibacterial activity against Pseudomonas aeruginosa FE57G with inactivated rplY and nuoG genes by microdilution method	2007	Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3	Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides.
AID520871	Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus saprophyticus isolate TSU57 isolated from genitourinary tracts of acute cystitis patient after 24 hrs at 35 degC by agar dilution method	2008	Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6	Methicillin-resistant Staphylococcus saprophyticus isolates carrying staphylococcal cassette chromosome mec have emerged in urogenital tract infections.
AID544281	Antimicrobial activity against Enterococcus faecalis NKH11 harboring pMG2200-like plasmid after 24 hrs by agar dilution method	2009	Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2	Isolation of VanB-type Enterococcus faecalis strains from nosocomial infections: first report of the isolation and identification of the pheromone-responsive plasmids pMG2200, Encoding VanB-type vancomycin resistance and a Bac41-type bacteriocin, and pMG2
AID368422	Antimicrobial activity against Escherichia coli KAM32 pSTVqepA containing qepA gene ligated to pSTV28 plasmid by agar dilution method	2007	Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9	New plasmid-mediated fluoroquinolone efflux pump, QepA, found in an Escherichia coli clinical isolate.
AID1271381	Antimicrobial activity against Gram-positive methicillin-resistant Staphylococcus aureus 1 after 16 to 24 hrs by micro-dilution method	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Synthesis and Biological Activity of Mono- and Di-N-acylated Aminoglycosides.
AID765041	Antibacterial activity against Staphylococcus aureus ATCC 25923 by MTT assay	2013	Bioorganic & medicinal chemistry, Sep-01, Volume: 21, Issue:17	3-Aryl-4-acyloxyethoxyfuran-2(5H)-ones as inhibitors of tyrosyl-tRNA synthetase: synthesis, molecular docking and antibacterial evaluation.
AID1565718	Antibacterial activity against Staphylococcus aureus ATCC 25923 incubated for 18 hrs by two fold dilution method	2019	European journal of medicinal chemistry, Nov-15, Volume: 182	Scalable and cost-effective tosylation-mediated synthesis of antifungal and fungal diagnostic 6″-Modified amphiphilic kanamycins.
AID425069	Antimicrobial activity against multidrug-resistant Klebsiella pneumoniae M7943 bearing qnrB10 gene with aac(6)-Ib-cr-blaOXA-30 catB3-arr-3 integron in presence of IPTG	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Complex class 1 integrons with diverse variable regions, including aac(6')-Ib-cr, and a novel allele, qnrB10, associated with ISCR1 in clinical enterobacterial isolates from Argentina.
AID584338	Antibacterial activity against tolC deficient Escherichia coli GD100 presence of 5 mM of glutathione	2010	Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12	Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics.
AID278261	Antimicrobial activity against Salmonella enterica serovar Typhimurium CHS14 gyrA+ with GyrA D87G mutation	2007	Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2	Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials.
AID1478537	Inhibition of Escherichia coli topoisomerase 4 using supercoiled pBR322 DNA as substrate by agarose gel electrophorosis method	2017	Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11	Covalently linked kanamycin - Ciprofloxacin hybrid antibiotics as a tool to fight bacterial resistance.
AID1906414	Antibacterial activity against Methicillin resistant Staphylococcus aureus ATCC BAA -1556 assessed as reduction in microbial growth incubated for 24 hrs by microbroth dilution method	2022	European journal of medicinal chemistry, May-05, Volume: 235	Amphiphilic cyclic peptide [W
AID445285	Antibacterial activity against Mycobacterium bovis BCG str. Tokyo 172 by broth dilution method	2009	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 19, Issue:22	Synthesis of new sugar derivatives and evaluation of their antibacterial activities against Mycobacterium tuberculosis.
AID556753	Bactericidal activity against sodB gene-deficient Escherichia coli K-12 3145 after 18 hrs	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	Contribution of oxidative damage to antimicrobial lethality.
AID1879068	Antibacterial activity against NDM-1 positive Escherichia coli ZC-YN3 isolates assessed as inhibition of bacterial growth incubated for 18 to 24 hrs by CLSI based broth microdilution method	2022	European journal of medicinal chemistry, Mar-05, Volume: 231	Metallo-β-lactamases inhibitor fisetin attenuates meropenem resistance in NDM-1-producing Escherichia coli.
AID244899	In-vitro minimum inhibitory concentration against the growth of Klebsiella pneumoniae	2005	Bioorganic & medicinal chemistry letters, Jul-01, Volume: 15, Issue:13	Synthesis of (1,4)-naphthoquinono-[3,2-c]-1H-pyrazoles and their (1,4)-naphthohydroquinone derivatives as antifungal, antibacterial, and anticancer agents.
AID587760	Antimicrobial activity against Mycobacterium ulcerans Mu1059 expressing luxAB from vibrio harveyi infected BALB/c mouse assessed as delay to time to foodpad swelling	2011	Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1	Using bioluminescence to monitor treatment response in real time in mice with Mycobacterium ulcerans infection.
AID1056537	Antibacterial activity against Micrococcus luteus by broth microdilution method	2013	Journal of natural products, Dec-27, Volume: 76, Issue:12	Cytotoxic and antibacterial marfuraquinocins from the deep South China Sea-derived Streptomyces niveus SCSIO 3406.
AID1868107	Antibacterial activity against methicillin-resistant Staphylococcus aureus clinical isolate 10B assessed as inhibition of visible bacterial growth incubated for 18 hrs by CLSI protocol based assay	2022	Journal of natural products, 05-27, Volume: 85, Issue:5	Enceleamycins A-C, Furo-Naphthoquinones from
AID381177	Antibacterial activity against Escherichia coli after 24 to 72 hrs by disk diffusion method	1999	Journal of natural products, Sep, Volume: 62, Issue:9	Antimicrobial and antitumor activities of mycosporulone.
AID510747	Antibacterial activity against Escherichia coli AG102MB harboring pSport1-based acrB gene	2010	Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3	Single nucleotide polymorphism analysis of the major tripartite multidrug efflux pump of Escherichia coli: functional conservation in disparate animal reservoirs despite exposure to antimicrobial chemotherapy.
AID1413328	Antifungal activity against Candida rugosa 95-967	2018	MedChemComm, Jun-01, Volume: 9, Issue:6	Antifungal amphiphilic kanamycins: new life for an old drug.
AID1593387	Growth inhibition of Escherichia coli DH5[alpha]	2019	Journal of medicinal chemistry, 04-11, Volume: 62, Issue:7	Identification of Novel Coumestan Derivatives as Polyketide Synthase 13 Inhibitors against Mycobacterium tuberculosis. Part II.
AID530286	Antimicrobial activity against PR-39-resistant Salmonella enterica serovar Typhimurium LT2 DA10899 harboring Q179Stop mutant gene by Etest	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Mechanism and fitness costs of PR-39 resistance in Salmonella enterica serovar Typhimurium LT2.
AID1710568	Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 assessed as reduction in bacterial growth at 64 uM incubated for 15 to 20 hrs by broth microdilution method relative to control	2018	MedChemComm, Jul-01, Volume: 9, Issue:7	Targeting miRNA by tunable small molecule binders: peptidic aminosugar mediated interference in miR-21 biogenesis reverts epithelial to mesenchymal transition.
AID1869572	Bactericidal activity against Acinetobacter baumannii DSM 300007 assessed as reduction in colony count and measured after 3 days by agar diffusion assay	2022	Journal of natural products, 06-24, Volume: 85, Issue:6	Triculamin: An Unusual Lasso Peptide with Potent Antimycobacterial Activity.
AID278556	Antimicrobial activity against 90 mins oxgall-stressed Bifidobacterium pseudolongum ATCC 25562 after 18 hrs	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID330983	Antimicrobial activity against Pseudomonas aeruginosa 27853	2007	Nature, May-03, Volume: 447, Issue:7140	PTC124 targets genetic disorders caused by nonsense mutations.
AID1890919	Antimicrobial activity against Staphylococcus aureus ATCC 51650 assessed as inhibition of microbial growth incubated for 16 hrs under shaking condition by microdilution assay	2022	Journal of natural products, 04-22, Volume: 85, Issue:4	Expanding the Chemical Diversity of Fasamycin Via Genome Mining and Biocatalysis.
AID1303896	Antibacterial activity against multidrug resistant Enterobacter cloacae subsp. cloacae CDC 442-68 (ATCC 13047) assessed as reduction in bacterial growth incubated for 6 to 8 hrs	2016	Bioorganic & medicinal chemistry letters, 07-01, Volume: 26, Issue:13	GroEL/ES inhibitors as potential antibiotics.
AID290149	Antifungal activity against Candida albicans after 48 hrs by MTT colorimetric method	2007	European journal of medicinal chemistry, Apr, Volume: 42, Issue:4	Synthesis and antimicrobial activities of Schiff bases derived from 5-chloro-salicylaldehyde.
AID364061	Antibacterial activity against Bacillus subtilis ATCC 6633 after 24 hrs by MTT assay	2008	European journal of medicinal chemistry, Sep, Volume: 43, Issue:9	Enamines as novel antibacterials and their structure-activity relationships.
AID441923	Antibacterial activity against Pseudomonas aeruginosa H45006 after 24 hrs by NCCLS method	2009	Journal of medicinal chemistry, Nov-12, Volume: 52, Issue:21	Coordination chemistry based approach to lipophilic inhibitors of 1-deoxy-D-xylulose-5-phosphate reductoisomerase.
AID524264	Antibacterial activity against Escherichia coli NKE158 harboring deletion mutation in acrB protein and vector expressing cpxAR gene	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Effect of NlpE overproduction on multidrug resistance in Escherichia coli.
AID725078	Antimicrobial activity against Salmonella typhimurium after 12 to 18 hrs by micro-well dilution method	2013	European journal of medicinal chemistry, Jan, Volume: 59	Synthesis and antibacterial and antifungal evaluation of some chalcone based sulfones and bisulfones.
AID364064	Antibacterial activity against Staphylococcus aureus ATCC 6538 after 24 hrs by MTT assay	2008	European journal of medicinal chemistry, Sep, Volume: 43, Issue:9	Enamines as novel antibacterials and their structure-activity relationships.
AID1428626	Antibacterial activity against methicillin-resistant Staphylococcus aureus USA300 by broth microdilution method	2017	European journal of medicinal chemistry, Feb-15, Volume: 127	Diaryltriazenes as antibacterial agents against methicillin resistant Staphylococcus aureus (MRSA) and Mycobacterium smegmatis.
AID551750	Antibacterial activity against Enterococcus faecalis ATCC 29212 after 12 to 18 hrs by twofold dilution method	2011	Bioorganic & medicinal chemistry, Jan-01, Volume: 19, Issue:1	Synthesis and antibacterial activity study of a novel class of cationic anthraquinone analogs.
AID441922	Antibacterial activity against Escherichia coli B/r after 24 hrs by NCCLS method	2009	Journal of medicinal chemistry, Nov-12, Volume: 52, Issue:21	Coordination chemistry based approach to lipophilic inhibitors of 1-deoxy-D-xylulose-5-phosphate reductoisomerase.
AID1262361	Antibacterial activity against clinical isolates Proteus vulgaris after 24 hrs by agar diffusion assay	2015	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 25, Issue:24	PPL catalyzed four-component PASE synthesis of 5-monosubstituted barbiturates: Structure and pharmacological properties.
AID625290	Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver fatty	2011	PLoS computational biology, Dec, Volume: 7, Issue:12	Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID1593385	Growth inhibition of Bacillus subtilis 168	2019	Journal of medicinal chemistry, 04-11, Volume: 62, Issue:7	Identification of Novel Coumestan Derivatives as Polyketide Synthase 13 Inhibitors against Mycobacterium tuberculosis. Part II.
AID1056535	Antibacterial activity against methicillin-resistant Staphylococcus epidermidis clinical isolate shhs-E1 by broth microdilution method	2013	Journal of natural products, Dec-27, Volume: 76, Issue:12	Cytotoxic and antibacterial marfuraquinocins from the deep South China Sea-derived Streptomyces niveus SCSIO 3406.
AID1525090	Antimicrobial activity against Mycobacterium smegmatis DSM 43524 by serial dilution assay	2019	Journal of natural products, 05-24, Volume: 82, Issue:5	Sesquiterpenes from an Eastern African Medicinal Mushroom Belonging to the Genus Sanghuangporus.
AID585017	Antibacterial activity against Mycobacterium smegmatis MC2 155 ATCC	2011	Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1	Inhibition of bacterial multidrug resistance by celecoxib, a cyclooxygenase-2 inhibitor.
AID718273	Antimicrobial activity against Bacillus subtilis ATCC 6633	2012	Journal of natural products, Dec-28, Volume: 75, Issue:12	Marthiapeptide A, an anti-infective and cytotoxic polythiazole cyclopeptide from a 60 L scale fermentation of the deep sea-derived Marinactinospora thermotolerans SCSIO 00652.
AID1418827	Antibacterial activity against Pseudomonas aeruginosa at 1 mg/ml after 48 hrs by agar well diffusion method	2018	Bioorganic & medicinal chemistry, 11-15, Volume: 26, Issue:21	Simplified lipid II-binding antimicrobial peptides: Design, synthesis and antimicrobial activity of bioconjugates of nisin rings A and B with pore-forming peptides.
AID1624150	Antitubercular activity against isoniazid/ethionamide resistant Mycobacterium tuberculosis isolate 2 after 7 days	2019	European journal of medicinal chemistry, Feb-15, Volume: 164	Synthesis and evaluation of α-aminoacyl amides as antitubercular agents effective on drug resistant tuberculosis.
AID574806	Antimycobacterial activity against extensively drug-resistant Mycobacterium tuberculosis isolate 625 horboring rpoB S531L/G566R/I569L, katG S315T/R463L, gyrA A90V/S95T, rrs A1401G by CLSI method	2010	Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11	Emergence and molecular characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates from the Delhi Region in India.
AID1852760	Antibacterial activity against Pseudomonas aeruginosa ATCC 9027 assessed as bacterial growth inhibition by broth microdilution assay	2022	RSC medicinal chemistry, Sep-21, Volume: 13, Issue:9	Design and evaluation of poly-nitrogenous adjuvants capable of potentiating antibiotics in Gram-negative bacteria.
AID283540	Antibacterial activity against Pseudomonas aeruginosa FE57Z with inactivated rplY and mexZ genes by microdilution method	2007	Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3	Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides.
AID424585	Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH380 (SCV-52) harboring -1 frameshift mutation at nucleotide 158 in rplF gene after 18 to 24 hrs by Etest strip assay	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID486969	Antibacterial activity against Escherichia coli after 24 hrs by micro broth dilution method	2010	European journal of medicinal chemistry, Jun, Volume: 45, Issue:6	'On water' assisted synthesis and biological evaluation of nitrogen and sulfur containing hetero-1,4-naphthoquinones as potent antifungal and antibacterial agents.
AID1055364	Antibacterial activity against Pseudomonas aeruginosa after 18 hrs by turbidity assay	2013	Journal of natural products, Nov-22, Volume: 76, Issue:11	Stereochemical assignment of the fungal metabolites pestalotiopsones D and E through enantiopure synthesis.
AID348959	Antibacterial activity against Escherichia coli after 24 hrs by MTT assay	2008	European journal of medicinal chemistry, Jul, Volume: 43, Issue:7	Synthesis and antimicrobial activities of 7-O-modified genistein derivatives.
AID1079936	Choleostatic liver toxicity, either proven histopathologically or where the ratio of maximal ALT or AST activity above normal to that of Alkaline Phosphatase is < 2 (see ACUTE). Value is number of references indexed. [column 'CHOLE' in source]
AID1337799	Antibacterial activity against Pseudomonas fluorescens NCIM 2036 measured after 8 hrs	2017	European journal of medicinal chemistry, Jan-05, Volume: 125	Quinolidene-rhodanine conjugates: Facile synthesis and biological evaluation.
AID759040	Inhibition of Escherichia coli FabH overexpressed in Escherichia coli DH10B using holo-ACP as substrate after 1 min	2013	European journal of medicinal chemistry, Jul, Volume: 65	Potentiating 1-(2-hydroxypropyl)-2-styryl-5-nitroimidazole derivatives against antibacterial agents: design, synthesis and biology analysis.
AID1176780	Antimicrobial activity against Candida glabrata ATCC 9984 after 24 hrs by broth microdilution method	2015	Journal of natural products, Jan-23, Volume: 78, Issue:1	Structure and antimicrobial activity of phloroglucinol derivatives from Achyrocline satureioides.
AID1177409	Antibacterial activity against Bacillus cereus CMCC 63302 after 7 hrs by Alamar Blue assay	2014	Journal of natural products, Aug-22, Volume: 77, Issue:8	Cytotoxic and Antibacterial Quinone Sesquiterpenes from a Myrothecium Fungus.
AID1617680	Antibacterial activity against methicillin-resistant Staphylococcus aureus shhs-A1 by CLSI based two-fold serial dilution method
AID1306204	Bactericidal activity against Escherichia coli ATCC 25922 after 18 hrs by microbroth dilution assay	2016	Bioorganic & medicinal chemistry, 07-15, Volume: 24, Issue:14	The influence of halogen substituents on the biological properties of sulfur-containing flavonoids.
AID424609	Antibacterial activity against kanamycin-resistant and fusidic acid-susceptible wild type Staphylococcus aureus 8325-4 clinical isolate after 18 to 24 hrs by Etest strip assay	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID1164946	Antimicrobial activity against Klebsiella pneumoniae ATCC 33495 at >200 ug/ml by microbroth dilution method	2014	Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20	Synthesis, structure-activity relationship studies, and antibacterial evaluation of 4-chromanones and chalcones, as well as olympicin A and derivatives.
AID278260	Antimicrobial activity against Salmonella enterica serovar Typhimurium CHS14 with GyrA D87G mutation	2007	Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2	Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials.
AID1710569	Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 1960649 assessed as reduction in bacterial growth at 64 uM incubated for 15 to 20 hrs by broth microdilution method relative to control	2018	MedChemComm, Jul-01, Volume: 9, Issue:7	Targeting miRNA by tunable small molecule binders: peptidic aminosugar mediated interference in miR-21 biogenesis reverts epithelial to mesenchymal transition.
AID278258	Antimicrobial activity against Salmonella enterica serovar Typhimurium CS9 acrAB::Kan with GyrA S83F, D87N, ParC S80I mutation	2007	Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2	Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials.
AID563500	Antimicrobial activity against Serratia marcescens ATCC 13880 by broth dilution method	2009	Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12	Mutational upregulation of a resistance-nodulation-cell division-type multidrug efflux pump, SdeAB, upon exposure to a biocide, cetylpyridinium chloride, and antibiotic resistance in Serratia marcescens.
AID326541	Antimicrobial activity against Mycobacterium abscessus R51 isolate after 3 to 5 days by broth microdilution method	2007	Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5	In Vitro activities of isepamicin, other aminoglycosides, and capreomycin against clinical isolates of rapidly growing mycobacteria in Taiwan.
AID1326389	Antibacterial activity against Bacillus subtilis P10B derived after 10 passage in presence of JBIR-100 after 16 to 18 hrs by microbroth dilution assay relative to Bacillus subtilis ATCC 47096	2016	Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24	Biological characterization of the hygrobafilomycin antibiotic JBIR-100 and bioinformatic insights into the hygrolide family of natural products.
AID1426251	Antibacterial activity against vancomycin-resistant Enterococcus faecalis ATCC 51299	2017	European journal of medicinal chemistry, Jan-27, Volume: 126	Synthesis and bioactivity investigation of quinone-based dimeric cationic triazolium amphiphiles selective against resistant fungal and bacterial pathogens.
AID1348089	Antimicrobial activity against Bacillus subtilis subsp. subtilis ATCC 6051 assessed as zone of inhibition at 50 ug per disc after 24 hrs by disc diffusion assay	2018	European journal of medicinal chemistry, Jan-01, Volume: 143	Synthesis of new 1-benzyl tetrahydropyridinylidene ammonium salts and their antimicrobial and anticellular activities.
AID509448	Antibacterial activity against Escherichia coli after 24 hrs by MTT assay	2010	European journal of medicinal chemistry, Sep, Volume: 45, Issue:9	Design and synthesis of potent inhibitors of beta-ketoacyl-acyl carrier protein synthase III (FabH) as potential antibacterial agents.
AID1079943	Malignant tumor, proven histopathologically. Value is number of references indexed. [column 'T.MAL' in source]
AID1562314	Antimycobacterial activity against Mycobacterium smegmatis atR19 assessed as decrease in drug resistance development at 5 ug/disc after 2 to 3 days by paper disc method	2019	European journal of medicinal chemistry, Sep-15, Volume: 178	Synthesis and antimycobacterial activity of imidazo[1,2-b][1,2,4,5]tetrazines.
AID1868105	Antibacterial activity against methicillin-resistant Staphylococcus aureus clinical isolate 6B assessed as inhibition of visible bacterial growth incubated for 18 hrs by CLSI protocol based assay	2022	Journal of natural products, 05-27, Volume: 85, Issue:5	Enceleamycins A-C, Furo-Naphthoquinones from
AID326545	Antimicrobial activity against Mycobacterium abscessus R54 isolate after 3 to 5 days by broth microdilution method	2007	Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5	In Vitro activities of isepamicin, other aminoglycosides, and capreomycin against clinical isolates of rapidly growing mycobacteria in Taiwan.
AID1299581	Antibacterial activity against Escherichia coli ANS1 incubated overnight by microbroth dilution method	2016	Journal of medicinal chemistry, Apr-14, Volume: 59, Issue:7	Antibacterial Diamines Targeting Bacterial Membranes.
AID565228	Antimicrobial activity against Mycobacterium chelonae ATCC 35752 by resazurine microtiter assay	2009	Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9	Role of porins in the susceptibility of Mycobacterium smegmatis and Mycobacterium chelonae to aldehyde-based disinfectants and drugs.
AID1585463	Antibacterial activity against gentamicin-resistant Staphylococcus aureus NRS-108 measured after 16 hrs	2019	European journal of medicinal chemistry, Jan-15, Volume: 162	Design, synthesis and evaluation of hybrid of tetrahydrocarbazole with 2,4-diaminopyrimidine scaffold as antibacterial agents.
AID1079934	Highest frequency of acute liver toxicity observed during clinical trials, expressed as a percentage. [column '% AIGUE' in source]
AID647791	Antibacterial activity Escherichia coli at 40 ug/disc after 24 hrs by agar disc diffusion method	2012	European journal of medicinal chemistry, Apr, Volume: 50	Synthesis of new α aminophosphonate system bearing Indazole moiety and their biological activity.
AID144146	Antibacterial activity against Mycobacterium kansasii	1985	Journal of medicinal chemistry, Dec, Volume: 28, Issue:12	Synthesis and antibacterial activity of 2,2'-dithiobis(benzamide) derivatives against Mycobacterium species.
AID625281	Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cholelithiasis	2011	PLoS computational biology, Dec, Volume: 7, Issue:12	Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID424598	Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH337 (SCV-9) harboring -1 frameshift mutation at nucleotide 220 in rplF gene after 18 to 24 hrs by Etest strip assay	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID534344	Antimicrobial activity against Burkholderia pseudomallei Bp174 harboring mini-Tn7T-bpeR+ after 24 hrs by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8	The BpeAB-OprB efflux pump of Burkholderia pseudomallei 1026b does not play a role in quorum sensing, virulence factor production, or extrusion of aminoglycosides but is a broad-spectrum drug efflux system.
AID1478545	Acute toxicity in iv dosed mouse at pH 6.6 administered for 4 days	2017	Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11	Covalently linked kanamycin - Ciprofloxacin hybrid antibiotics as a tool to fight bacterial resistance.
AID1347680	Growth inhibition of Yersinia pseudotuberculosis harboring pYV deletion mutant at 50 ug/ml measured at 30 mins interval for 8 hrs	2017	Journal of natural products, 12-22, Volume: 80, Issue:12	Investigation of the Physical and Bioactive Properties of Bromo- and Iodo-Containing Sponge-Derived Compounds Possessing an Oxyphenylethanamine Core.
AID425070	Antimicrobial activity against multidrug-resistant Escherichia coli M7943-TC2 bearing qnrB10 gene with aac(6)-Ib-cr-blaOXA-30 catB3-arr-3 integron in presence of IPTG	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Complex class 1 integrons with diverse variable regions, including aac(6')-Ib-cr, and a novel allele, qnrB10, associated with ISCR1 in clinical enterobacterial isolates from Argentina.
AID569255	Antimycobacterial activity against Mycobacterium tuberculosis H37Rv	2011	Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3	Synthesis and evaluation of anti-tubercular activity of new dithiocarbamate sugar derivatives.
AID521601	Antibacterial activity against Salmonella enterica serovars virchow isolate 101591 infected in mouse J774A.1 macrophage assessed as log reduction in viable counts at 150 ug/ml after 1hr	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	Aminoglycosides affect intracellular Salmonella enterica serovars typhimurium and virchow.
AID251751	Antimycobacterial activity of compound against Mycobacterium tuberculosis H37Rv at 5 ug/mL	2004	Bioorganic & medicinal chemistry letters, Aug-02, Volume: 14, Issue:15	Antituberculous activity of some aryl semicarbazone derivatives.
AID1164947	Antimicrobial activity against Pseudomonas aeruginosa PAO1 at >200 ug/ml by microbroth dilution method	2014	Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20	Synthesis, structure-activity relationship studies, and antibacterial evaluation of 4-chromanones and chalcones, as well as olympicin A and derivatives.
AID1455934	Antibacterial activity against Staphylococcus aureus after 48 hrs by broth micro-dilution method	2017	Journal of natural products, 02-24, Volume: 80, Issue:2	Nabscessins A and B, Aminocyclitol Derivatives from Nocardia abscessus IFM 10029
AID584332	Antibacterial activity against tolC, gshB deficient Escherichia coli GD107	2010	Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12	Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics.
AID1624156	Antitubercular activity against multidrug-resistant Mycobacterium tuberculosis isolate 8 after 7 days	2019	European journal of medicinal chemistry, Feb-15, Volume: 164	Synthesis and evaluation of α-aminoacyl amides as antitubercular agents effective on drug resistant tuberculosis.
AID476722	Antibacterial activity against Bacillus subtilis ATCC 6633 after 24 hrs by colorimetric method using dye MTT	2010	Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7	Synthesis, molecular modeling and biological evaluation of PSB as targeted antibiotics.
AID278237	Antimicrobial activity against Salmonella enterica serovar Typhimurium S21-2 gyrA+ with ParC S80I mutation	2007	Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2	Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials.
AID1478542	Antibacterial activity against Escherichia coli ATCC 35218 in 15th subculture in presence of equimolar concentration of ciprofloxacin by double microdilution method	2017	Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11	Covalently linked kanamycin - Ciprofloxacin hybrid antibiotics as a tool to fight bacterial resistance.
AID1271385	Antimicrobial activity against Mycobacterium smegmatis MC2-155 after 16 to 24 hrs by micro-dilution method	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Synthesis and Biological Activity of Mono- and Di-N-acylated Aminoglycosides.
AID278271	Antimicrobial activity against Salmonella enterica serovar Typhimurium CHS38 tolC::Kan with GyrA D87G mutation	2007	Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2	Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials.
AID584831	Antibacterial activity against Neisseria gonorrhoeae	2010	Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1	Chip calorimetry for fast and reliable evaluation of bactericidal and bacteriostatic treatments of biofilms.
AID1562317	Antimycobacterial activity against Mycobacterium smegmatis atR40 assessed as decrease in drug resistance development at 5 ug/disc after 2 to 3 days by paper disc method	2019	European journal of medicinal chemistry, Sep-15, Volume: 178	Synthesis and antimycobacterial activity of imidazo[1,2-b][1,2,4,5]tetrazines.
AID520702	Antibacterial activity against tetracycline resistant Streptococcus pneumoniae clinical isolate expressing Tn6002 carrying erm(B) and tet(M) gene at 1000 ug by disk diffusion method	2008	Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4	erm(B)-carrying elements in tetracycline-resistant pneumococci and correspondence between Tn1545 and Tn6003.
AID1617942	Antibacterial activity against Bacillus subtilis ATCC 6633 after 16 to 48 hrs	2019	Journal of natural products, 12-27, Volume: 82, Issue:12	Structure Determination, Functional Characterization, and Biosynthetic Implications of Nybomycin Metabolites from a Mining Reclamation Site-Associated
AID588211	Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in humans	2010	Chemical research in toxicology, Jan, Volume: 23, Issue:1	Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
AID1565717	Antibacterial activity against Escherichia coli ATCC 25922 incubated for 18 hrs by two fold dilution method	2019	European journal of medicinal chemistry, Nov-15, Volume: 182	Scalable and cost-effective tosylation-mediated synthesis of antifungal and fungal diagnostic 6″-Modified amphiphilic kanamycins.
AID683687	Kinetic solubility of the compound at pH 7.4	2012	European journal of medicinal chemistry, Nov, Volume: 57	The design, synthesis, in silico ADME profiling, antiplasmodial and antimycobacterial evaluation of new arylamino quinoline derivatives.
AID1675235	Antimicrobial activity against Mycobacterium smegmatis DSM44200 by serial dilution method	2020	Journal of natural products, 08-28, Volume: 83, Issue:8	Heimiomycins A-C and Calamenens from the African Basidiomycete
AID424578	Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH338 (SCV-10) harboring Arg464Cys mutation in fusA gene after 18 to 24 hrs by Etest strip assay	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID540209	Volume of distribution at steady state in human after iv administration	2008	Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7	Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
AID544278	Antimicrobial activity against Enterococcus faecalis NKH8 harboring pMG2200-like and pMG2201-like plasmids after 24 hrs by agar dilution method	2009	Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2	Isolation of VanB-type Enterococcus faecalis strains from nosocomial infections: first report of the isolation and identification of the pheromone-responsive plasmids pMG2200, Encoding VanB-type vancomycin resistance and a Bac41-type bacteriocin, and pMG2
AID163066	ntibacterial activity expressed as MIC value was determined on Proteus rettgeri A-21207 organism	1986	Journal of medicinal chemistry, May, Volume: 29, Issue:5	Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin.
AID1418825	Antibacterial activity against Micrococcus luteus at 1 mg/ml after 48 hrs by agar well diffusion method	2018	Bioorganic & medicinal chemistry, 11-15, Volume: 26, Issue:21	Simplified lipid II-binding antimicrobial peptides: Design, synthesis and antimicrobial activity of bioconjugates of nisin rings A and B with pore-forming peptides.
AID490135	Antibacterial activity against Staphylococcus aureus ATCC 6538 after 24 hrs by MTT assay	2010	European journal of medicinal chemistry, Jul, Volume: 45, Issue:7	Synthesis of some N-alkyl substituted urea derivatives as antibacterial and antifungal agents.
AID164370	Antibacterial activity expressed as MIC value was determined on Pseudomonas aeruginosa A-21509 organism	1986	Journal of medicinal chemistry, May, Volume: 29, Issue:5	Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin.
AID1265800	Antibacterial activity against Salmonella enterica ATCC 14028 by microdilution method	2015	Journal of medicinal chemistry, Dec-10, Volume: 58, Issue:23	Synthesis and Bioactivities of Kanamycin B-Derived Cationic Amphiphiles.
AID619544	Antibacterial activity against Staphylococcus aureus ATCC 25923 after 24 hrs by MTT assay	2011	European journal of medicinal chemistry, Oct, Volume: 46, Issue:10	Tyrosyl-tRNA synthetase inhibitors as antibacterial agents: synthesis, molecular docking and structure-activity relationship analysis of 3-aryl-4-arylaminofuran-2(5H)-ones.
AID1890846	Selectivity index, ratio of MIC90 for antimycobacterial activity against Mycobacterium smegmatis mc2 155 harbouring pMyC empty vector to MIC90 for antimycobacterial activity against wild type Mycobacterium smegmatis mc2 155	2022	Bioorganic & medicinal chemistry letters, 05-15, Volume: 64	Design, synthesis and antibacterial activity against pathogenic mycobacteria of conjugated hydroxamic acids, hydrazides and O-alkyl/O-acyl protected hydroxamic derivatives.
AID1348087	Antimicrobial activity against Staphylococcus aureus subsp. aureus ATCC 25923 assessed as zone of inhibition at 50 ug per disc after 24 hrs by disc diffusion assay	2018	European journal of medicinal chemistry, Jan-01, Volume: 143	Synthesis of new 1-benzyl tetrahydropyridinylidene ammonium salts and their antimicrobial and anticellular activities.
AID477409	Antibacterial activity against Staphylococcus aureus NCTC 8325 after 16 to 20 hrs by broth microdilution method	2010	Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6	Efflux-mediated bis-indole resistance in Staphylococcus aureus reveals differential substrate specificities for MepA and MepR.
AID1402050	Antibacterial activity against methicillin-sensitive Staphylococcus aureus ATCC 25923 after 18 to 20 hrs by spectrophotometry based microdilution method	2018	European journal of medicinal chemistry, Jan-01, Volume: 143	Synthesis and antimicrobial activity of amino acid and peptide derivatives of mycophenolic acid.
AID563506	Antimicrobial activity against cetylpyridinium chloride-sensitive Serratia marcescens 71 harboring plasmid STV29 by broth dilution method	2009	Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12	Mutational upregulation of a resistance-nodulation-cell division-type multidrug efflux pump, SdeAB, upon exposure to a biocide, cetylpyridinium chloride, and antibiotic resistance in Serratia marcescens.
AID534337	Antimicrobial activity against Burkholderia pseudomallei Bp216 harboring mini-Tn7T after 24 hrs by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8	The BpeAB-OprB efflux pump of Burkholderia pseudomallei 1026b does not play a role in quorum sensing, virulence factor production, or extrusion of aminoglycosides but is a broad-spectrum drug efflux system.
AID283541	Antibacterial activity against Pseudomonas aeruginosa FE53GU with inactivated mexZ, nuoG and galU genes by microdilution method	2007	Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3	Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides.
AID164372	Antibacterial activity expressed as MIC value was determined on Pseudomonas aeruginosa A-9834A organism	1986	Journal of medicinal chemistry, May, Volume: 29, Issue:5	Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin.
AID544280	Antimicrobial activity against Enterococcus faecalis NKH10 harboring pMG2200-like and pMG2201-like plasmids after 24 hrs by agar dilution method	2009	Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2	Isolation of VanB-type Enterococcus faecalis strains from nosocomial infections: first report of the isolation and identification of the pheromone-responsive plasmids pMG2200, Encoding VanB-type vancomycin resistance and a Bac41-type bacteriocin, and pMG2
AID1565715	Antifungal activity against Rhodotorula pilimanae ATCC 26423 incubated for 24 to 36 hrs by two fold dilution method	2019	European journal of medicinal chemistry, Nov-15, Volume: 182	Scalable and cost-effective tosylation-mediated synthesis of antifungal and fungal diagnostic 6″-Modified amphiphilic kanamycins.
AID1477417	Antibacterial activity against 6-((3-Fluorobenzyl)(methyl)amino)-N-(4-methoxyphenyl)-pyrimidine-4-carboxamide-resisitant Mycobacterium tuberculosis H37Rv grown in GAST/Fe medium measured on day 14 post inoculation by broth microdilution method	2017	Journal of medicinal chemistry, 12-28, Volume: 60, Issue:24	Novel Antitubercular 6-Dialkylaminopyrimidine Carboxamides from Phenotypic Whole-Cell High Throughput Screening of a SoftFocus Library: Structure-Activity Relationship and Target Identification Studies.
AID1629131	Antimicrobial activity against aminoglycoside-resistant Escherichia coli ATCC BAA-2452 measured after 24 hrs by double-dilution method	2016	Journal of medicinal chemistry, 09-08, Volume: 59, Issue:17	Effects of 5-O-Ribosylation of Aminoglycosides on Antimicrobial Activity and Selective Perturbation of Bacterial Translation.
AID1402052	Antibacterial activity against Escherichia coli ATCC 8739 after 18 to 20 hrs by spectrophotometry based microdilution method	2018	European journal of medicinal chemistry, Jan-01, Volume: 143	Synthesis and antimicrobial activity of amino acid and peptide derivatives of mycophenolic acid.
AID278255	Antimicrobial activity against Salmonella enterica serovar Typhimurium CS3 tolC::Kan with GyrA S83F, D87N, parC S80I mutation	2007	Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2	Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials.
AID1207005	Antibacterial activity against Staphylococcus epidermidis assessed as growth inhibition at 5 ug/disc after 24 hrs by disc diffusion method	2015	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 25, Issue:12	An antibacterial ortho-quinone diterpenoid and its derivatives from Caryopteris mongolica.
AID278561	Antimicrobial activity against 90 mins hydrogen peroxide-stressed Bifidobacterium breve ATCC 15700 after 18 hrs	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID625292	Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) combined score	2011	PLoS computational biology, Dec, Volume: 7, Issue:12	Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID424830	Antibacterial activity against kanamycin-resistant and fusidic acid-susceptible Staphylococcus aureus AH417 harboring -1 frameshift mutation at nucleotide 422 in rplF gene after 18 to 24 hrs by Etest strip assay	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID330982	Antimicrobial activity against Escherichia coli BAS849	2007	Nature, May-03, Volume: 447, Issue:7140	PTC124 targets genetic disorders caused by nonsense mutations.
AID521593	Antibacterial activity against Salmonella enterica serovars Typhimurium ATCC 14028 at pH 7.0 by broth dilution method	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	Aminoglycosides affect intracellular Salmonella enterica serovars typhimurium and virchow.
AID1594070	Antibacterial activity against methicillin-resistant Staphylococcus aureus assessed as reduction in bacterial cell viability incubated for 20 to 24 hrs by REMA method	2019	Bioorganic & medicinal chemistry, 06-15, Volume: 27, Issue:12	Design, synthesis, in-silico studies and biological screening of quinazolinone analogues as potential antibacterial agents against MRSA.
AID400955	Antimicrobial activity against Escherichia coli ATCC 25922 by serial broth microdilution method	2004	Journal of natural products, Apr, Volume: 67, Issue:4	Further labdane and kaurane diterpenoids and other constituents from Plectranthus fruticosus.
AID1730994	Antitubercular activity against isoniazid/rifampin/levofloxacin/ofloxacin/kanamycin extensively drug resistance Mycobacterium tuberculosis TF274 XDR by MABA assay	2021	European journal of medicinal chemistry, Mar-05, Volume: 213	Design and synthesis of mycobacterial pks13 inhibitors: Conformationally rigid tetracyclic molecules.
AID1695861	Antibacterial activity against Bacillus cereus ATCC 6630 incubated for 24 hrs	2019	European journal of medicinal chemistry, Apr-15, Volume: 168	Comprehensive review on the anti-bacterial activity of 1,2,3-triazole hybrids.
AID424591	Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH333 (SCV-5) harboring TAA stop codon at nucleotide 249 in rplF but gene after 18 to 24 hrs by Etest strip assay	2007	Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12	Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.
AID283535	Antibacterial activity against Pseudomonas aeruginosa FE10U with inactivated nuoG and galU genes by microdilution method	2007	Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3	Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides.
AID1478530	Antibacterial activity against aminoglycosides-resistant Escherichia coli BL21 harboring pET11d encode for APH(3')-2b resistance enzyme by double microdilution method	2017	Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11	Covalently linked kanamycin - Ciprofloxacin hybrid antibiotics as a tool to fight bacterial resistance.
AID162906	Antibacterial activity expressed as MIC value was determined on Proteus rettgeri A-9637 organism	1986	Journal of medicinal chemistry, May, Volume: 29, Issue:5	Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin.
AID1657554	Antimicrobial activity against Shigella dysenteriae incubated for 7 hrs by alamar Blue assay
AID1765573	Antibacterial activity against Staphylococcus aureus ATCC 25923 incubated for 18 hrs by CLSI based broth dilution method	2021	Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15	Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1663465	Antibacterial activity against Escherichia coli ATCC 8099 incubated for 16 hrs by broth microdilution method	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Antibacterial Pentacyclic Polyketides from a Soil-Derived
AID325445	Antibacterial activity against Escherichia coli C921-61 after 14 to 16 hrs by broth dilution method	2007	Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6	Polyamine effects on antibiotic susceptibility in bacteria.
AID1225389	Antibacterial activity against Escherichia coli transformed with plasmid carrying MG1655 deltaBC/pXYM by p-iodonitrotetrazolium chloride colorimetric assay	2015	Journal of natural products, Mar-27, Volume: 78, Issue:3	Enhancement of antibiotic activity against multidrug-resistant bacteria by the efflux pump inhibitor 3,4-dibromopyrrole-2,5-dione isolated from a Pseudoalteromonas sp.
AID1159607	Screen for inhibitors of RMI FANCM (MM2) intereaction	2016	Journal of biomolecular screening, Jul, Volume: 21, Issue:6	A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	4757 (71.10)	18.7374
1990's	400 (5.98)	18.2507
2000's	505 (7.55)	29.6817
2010's	787 (11.76)	24.3611
2020's	242 (3.62)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	187 (2.61%)	5.53%
Reviews	203 (2.83%)	6.00%
Case Studies	203 (2.83%)	4.05%
Observational	2 (0.03%)	0.25%
Other	6,574 (91.70%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Article	Year
Protective Effects of Infliximab Against Kanamycin-Induced Ototoxicity in Rats. Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, Aug-01, Volume: 44, Issue: 7	2023
A reduced form of nicotinamide riboside protects the cochlea against aminoglycoside-induced ototoxicity by SIRT1 activation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, Volume: 150	2022
The ototoxic effect of locally applied kanamycin and furosemide in guinea pigs. Journal of neuroscience methods, Apr-15, Volume: 372	2022
Telmisartan Attenuates Kanamycin-Induced Ototoxicity in Rats. International journal of molecular sciences, Nov-24, Volume: 22, Issue: 23	2021
Systemic toll-like receptor 9 agonist CpG oligodeoxynucleotides exacerbates aminoglycoside ototoxicity. Hearing research, Volume: 411	2021
[Kanamycin-induced ototoxicity during treatment of multidrug-resistant tuberculosis]. Revue des maladies respiratoires, Volume: 37, Issue: 5	2020
Nephrotoxicity and ototoxic symptoms of injectable second-line anti-tubercular drugs among patients treated for MDR-TB in Ethiopia: a retrospective cohort study. BMC pharmacology & toxicology, 05-23, Volume: 20, Issue: 1	2019
The Novel Peptide Vaccine GV1001 Protects Hearing in a Kanamycin-induced Ototoxicity Mouse Model. Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, Volume: 39, Issue: 8	2018
Risk of Nephrotoxicity in Patients With Drug-Resistant Tuberculosis Treated With Kanamycin/Capreomycin With or Without Concomitant Use of Tenofovir-Containing Antiretroviral Therapy. Journal of acquired immune deficiency syndromes (1999), 08-15, Volume: 78, Issue: 5	2018
The expression of oxidative stress response genes is modulated by a combination of resveratrol and N-acetylcysteine to ameliorate ototoxicity in the rat cochlea. Hearing research, Volume: 358	2018
Clinical predictors of aminoglycoside-induced ototoxicity in drug-resistant Tuberculosis patients on intensive therapy. Auris, nasus, larynx, Volume: 44, Issue: 4	2017
Gitelman-like Syndrome with Kanamycin Toxicity. The Journal of the Association of Physicians of India, Volume: 64, Issue: 5	2016
The safety and tolerability of the second-line injectable antituberculosis drugs in children. Expert opinion on drug safety, Volume: 15, Issue: 11	2016
Frequency of adverse events observed with second-line drugs among patients treated for multidrug-resistant tuberculosis. The Indian journal of tuberculosis, Volume: 63, Issue: 2	2016
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships. Bioorganic & medicinal chemistry letters, 08-15, Volume: 26, Issue: 16	2016
D-methionine (D-met) significantly reduces kanamycin-induced ototoxicity in pigmented guinea pigs. International journal of audiology, Volume: 55, Issue: 5	2016
Integrate genome-based assessment of safety for probiotic strains: Bacillus coagulans GBI-30, 6086 as a case study. Applied microbiology and biotechnology, Volume: 100, Issue: 10	2016
Evidence That Antibiotics Bind to Human Mitochondrial Ribosomal RNA Has Implications for Aminoglycoside Toxicity. The Journal of biological chemistry, Jul-31, Volume: 290, Issue: 31	2015
Aminoglycoside ototoxicity and hair cell ablation in the adult gerbil: A simple model to study hair cell loss and regeneration. Hearing research, Volume: 325	2015
17-DMAG induces Hsp70 and protects the auditory hair cells from kanamycin ototoxicity in vitro. Neuroscience letters, Feb-19, Volume: 588	2015
Systemic lipopolysaccharide induces cochlear inflammation and exacerbates the synergistic ototoxicity of kanamycin and furosemide. Journal of the Association for Research in Otolaryngology : JARO, Volume: 15, Issue: 4	2014
Development of an ototoxicity model in the adult CBA/CaJ mouse and determination of a golden window of corticosteroid intervention for otoprotection. Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale, Apr-24, Volume: 43	2014
Nestin expression and reactive phenomena in the mouse cochlea after kanamycin ototoxicity. The European journal of neuroscience, Volume: 39, Issue: 11	2014
Protective effect of rasagiline in aminoglycoside ototoxicity. Neuroscience, Apr-18, Volume: 265	2014
In vitro evaluation of the safety and probiotic properties of Lactobacilli isolated from chicken and calves. Anaerobe, Volume: 29	2014
Examination of calcium-binding protein expression in the inner ear of wild-type, heterozygous and homozygous pituitary adenylate cyclase-activating polypeptide (PACAP)-knockout mice in kanamycin-induced ototoxicity. Neurotoxicity research, Volume: 25, Issue: 1	2014
New function of molybdenum trioxide nanoplates: toxicity towards pathogenic bacteria through membrane stress. Colloids and surfaces. B, Biointerfaces, Dec-01, Volume: 112	2013
Reversible neurotoxicity of kanamycin on dorsal cochlear nucleus. Brain research, Mar-28, Volume: 1502	2013
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). PLoS computational biology, Volume: 7, Issue: 12	2011
[Expression of TMPRSS3 in the rat cochlea following kanamycin ototoxicity]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, Volume: 36, Issue: 10	2011
[Ototoxicity of kanamycin sulfate in adult rats and its underlying mechanisms]. Sheng li xue bao : [Acta physiologica Sinica], Apr-25, Volume: 63, Issue: 2	2011
A protective mechanism against antibiotic-induced ototoxicity: role of prestin. PloS one, Feb-25, Volume: 6, Issue: 2	2011
Transmembrane distribution of kanamycin and chloramphenicol: insights into the cytotoxicity of antibacterial drugs. Molecular bioSystems, Volume: 6, Issue: 10	2010
Direct drug application to the round window: a comparative study of ototoxicity in rats. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, Volume: 141, Issue: 5	2009
Comparison of different aminoglycoside antibiotic treatments to refine ototoxicity studies in adult mice. Laboratory animals, Volume: 44, Issue: 2	2010
[Sensitivity to the ototoxicity of kanamycin of the rat model for mimetic aging in the inner ear]. Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery, Volume: 43, Issue: 1	2008
Phenotypic typing, technological properties and safety aspects of Lactococcus garvieae strains from dairy environments. Journal of applied microbiology, Volume: 103, Issue: 2	2007
Aminoglycoside ototoxicity in three murine strains and effects on NKCC1 of stria vascularis. Chinese medical journal, Jun-20, Volume: 119, Issue: 12	2006
[Kanamycin induced ototoxicity in three kinds of mouse strains and its effects on the expression of na-K-2Cl co-transporter-1 in stria vascularis]. Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery, Volume: 41, Issue: 1	2006
Kanamycin ototoxicity in glutamate transporter knockout mice. Neuroscience letters, Jun-03, Volume: 380, Issue: 3	2005
Aminoglycoside toxicity: daily versus thrice-weekly dosing for treatment of mycobacterial diseases. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Jun-01, Volume: 38, Issue: 11	2004
Tanshinone (Salviae miltiorrhizae extract) preparations attenuate aminoglycoside-induced free radical formation in vitro and ototoxicity in vivo. Antimicrobial agents and chemotherapy, Volume: 47, Issue: 6	2003
[Morphologic studies of the protective role of catechin on kanamycin otoneurotoxicity in SD rats]. Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University, Dec-28, Volume: 27, Issue: 6	2002
Antibacterial activity and cytotoxicity of extractives from Uvaria hamiltonii stem bark. Fitoterapia, Volume: 74, Issue: 1-2	2003
Intra-cochlear administration of dexamethasone attenuates aminoglycoside ototoxicity in the guinea pig. Hearing research, Volume: 167, Issue: 1-2	2002
Hearing loss and nephrotoxicity in long-term aminoglycoside treatment in patients with tuberculosis. The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, Volume: 6, Issue: 7	2002
Aminoglycoside ototoxicity in adult CBA, C57BL and BALB mice and the Sprague-Dawley rat. Hearing research, Volume: 158, Issue: 1-2	2001
Efficacy and safety of sparfloxacin in combination with kanamycin and ethionamide in multidrug-resistant pulmonary tuberculosis patients: preliminary results. The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, Volume: 5, Issue: 6	2001
The reinnervation of regenerated hair cells in the basilar papilla of chicks after kanamycin ototoxicity. Acta oto-laryngologica, Volume: 120, Issue: 8	2000
Temporal bone studies of the human peripheral vestibular system. Aminoglycoside ototoxicity. The Annals of otology, rhinology & laryngology. Supplement, Volume: 181	2000
A role of glutamate in drug-induced ototoxicity: in vivo microdialysis study combined with on-line enzyme fluorometric detection of glutamate in the guinea pig cochlea. Brain research, Jan-10, Volume: 852, Issue: 2	2000
Increased susceptibility of male rats to kanamycin-induced cochleotoxicity. Hearing research, Volume: 128, Issue: 1-2	1999
Iron chelators protect from aminoglycoside-induced cochleo- and vestibulo-toxicity. Free radical biology & medicine, Jul-15, Volume: 25, Issue: 2	1998
Ototoxicity of aminoglycoside drugs in tuberculosis treatment. The South African journal of communication disorders = Die Suid-Afrikaanse tydskrif vir Kommunikasieafwykings, Volume: 43	1996
Sensitive developmental periods for kanamycin ototoxic effects on distortion-product otoacoustic emissions. Hearing research, Sep-01, Volume: 98, Issue: 1-2	1996
Regenerated hair cells exhibit a transient resistance to aminoglycoside toxicity. Brain research, May-13, Volume: 720, Issue: 1-2	1996
[Effect of ligustrazine on kanamycin ototoxicity]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, Volume: 15, Issue: 10	1995
Onset of ototoxicity in the cat is related to onset of auditory function. Hearing research, Volume: 92, Issue: 1-2	1995
[Kanamycin ototoxicity and melanin in the inner ear]. Zhonghua er bi yan hou ke za zhi, Volume: 28, Issue: 1	1993
Study on fluorination-toxicity relationships. Syntheses of 1-N-[(2R,3R)- and (2R,3S)-4-amino-3-fluoro-2-hydroxybutanoyl] derivatives of kanamycins. Carbohydrate research, Oct-18, Volume: 249, Issue: 1	1993
[An electron microscopic study of thyroxine against ototoxicity of kanamycin]. Zhonghua er bi yan hou ke za zhi, Volume: 28, Issue: 6	1993
The ototoxicity of 3,3'-iminodipropionitrile: functional and morphological evidence of cochlear damage. Hearing research, Volume: 80, Issue: 2	1994
Regenerated hair cells in the European starling: are they more resistant to kanamycin ototoxicity than original hair cells? Hearing research, Volume: 82, Issue: 2	1995
Ototoxicity in developing mammals. Brain research. Brain research reviews, Volume: 20, Issue: 1	1995
Protection by lysosomal hydrolase inhibitors against cytotoxicity of 2-chloroethylethyl sulfide. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, Volume: 33, Issue: 7	1995
[Effects of poria cocos on ototoxicity induced by kanamycin in guinea-pigs]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, Volume: 15, Issue: 7	1995
Increased ototoxicity in both young and old mice. Archives of otolaryngology (Chicago, Ill. : 1960), Volume: 107, Issue: 2	1981
Comparative ototoxicity of chloramphenicol and kanamycin with ethacrynic acid. Archives of otolaryngology (Chicago, Ill. : 1960), Volume: 107, Issue: 2	1981
Kanamycin ototoxicity and pigmentation in the guinea pig. Hearing research, Volume: 3, Issue: 3	1980
[Toxicological studies on dibekacin for intravenous injection use. II. Chronic toxicity in rats (author's transl)]. The Japanese journal of antibiotics, Volume: 33, Issue: 5	1980
[Toxicological studies on dibekacin for intravenous injection use. I. Subacute toxicity in rats and rabbits (author's transl)]. The Japanese journal of antibiotics, Volume: 33, Issue: 5	1980
Comparative ototoxic effects of RU 25434, amikacin and neomycin in guinea-pigs. Acta pharmacologica et toxicologica, Volume: 46, Issue: 4	1980
Ototoxicity of kanamycin in developing rats: relationship with the onset of the auditory function. Hearing research, Volume: 2, Issue: 2	1980
Comparative nephrotoxicity of dibekacin and gentamicin in rats. Research communications in chemical pathology and pharmacology, Volume: 33, Issue: 3	1981
Acute toxicity and pharmacokinetics of dibekacin mice. Journal of pharmacobio-dynamics, Volume: 4, Issue: 5	1981
Amikacin and gentamicin accumulation pharmacokinetics and nephrotoxicity in critically ill patients. Antimicrobial agents and chemotherapy, Volume: 19, Issue: 1	1981
[Animal experiments on the nephrotoxicity, pharmacokinetics and therapeutic efficacy of dibekacin]. Arzneimittel-Forschung, Volume: 31, Issue: 3	1981
Mode of protective action of fosfomycin against dibekacin-induced nephrotoxicity in the dehydrated rats. Journal of pharmacobio-dynamics, Volume: 5, Issue: 12	1982
Evaluation of ototoxicity of amino-glycoside antibiotics in rabbits. Auris, nasus, larynx, Volume: 9, Issue: 2	1982
[Experimental study of the intrauterine ototoxicity of dibekacin]. La Nouvelle presse medicale, Nov-18, Volume: 11, Issue: 46	1982
[Toxicological study of amikacin following intravenous drip infusion. 2. Subacute toxicity in dogs after intravenous injection]. The Japanese journal of antibiotics, Volume: 35, Issue: 8	1982
[Toxicological study of amikacin following intravenous drip infusion. 1. Acute toxicity in rats, rabbits and dogs, and subacute toxicity in rabbits]. The Japanese journal of antibiotics, Volume: 35, Issue: 8	1982
Protective effect of fosfomycin on the experimental nephrotoxicity induced by dibekacin. Journal of pharmacobio-dynamics, Volume: 5, Issue: 9	1982
Kanamycin induced ototoxicity in the laboratory rat. A comparative morphological and audiometric study. Archives of toxicology, Volume: 50, Issue: 3-4	1982
[Electrophysiological study of the ototoxicity of kanamycin via transplacental transmission in the guinea pig (author's transl)]. Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Societe d'oto-laryngologie des hopitaux de Paris, Volume: 99, Issue: 3	1982
Ototoxicity of aminoglycoside antibiotics by rapid intravenous injection. ORL; journal for oto-rhino-laryngology and its related specialties, Volume: 44, Issue: 3	1982
Renal and Auditory toxic effects of amikacin in children with cancer. American journal of diseases of children (1960), Volume: 136, Issue: 3	1982
Antimicrobial spectrum, pharmacology, adverse effects, and therapeutic use of amikacin sulfate. American journal of hospital pharmacy, Volume: 38, Issue: 7	1981
Prospective, randomized trial of netilmicin and amikacin, with emphasis on eighth-nerve toxicity. Antimicrobial agents and chemotherapy, Volume: 17, Issue: 4	1980
Prospective comparative study of efficacy and toxicity of netilmicin and amikacin. Antimicrobial agents and chemotherapy, Volume: 17, Issue: 2	1980
Adverse effects of antituberculosis drugs causing changes in treatment. Tubercle, Volume: 63, Issue: 4	1982
Effect of furosemide on aminoglycoside-induced nephrotoxicity and auditory toxicity in humans. Antimicrobial agents and chemotherapy, Volume: 23, Issue: 1	1983
Risk factors for the development of auditory toxicity in patients receiving aminoglycosides. The Journal of infectious diseases, Volume: 149, Issue: 1	1984
[Clinical evaluation of ototoxicity associated with intravenous drip infusion of amikacin]. The Japanese journal of antibiotics, Volume: 36, Issue: 10	1983
The sensitive period for ototoxicity of kanamycin in mice: morphological evidence. Archives of oto-rhino-laryngology, Volume: 238, Issue: 3	1983
A prospective, randomized study of amikacin and gentamicin in serious infections with focus on efficacy, toxicity and duration of serum levels above the MIC. The Journal of antimicrobial chemotherapy, Volume: 12, Issue: 4	1983
Comparative ototoxicity of dibekacin and netilmicin in guinea pigs. Acta pharmacologica et toxicologica, Volume: 53, Issue: 3	1983
Comparison of the nephrotoxicity and auditory toxicity of tobramycin and amikacin. Antimicrobial agents and chemotherapy, Volume: 23, Issue: 6	1983
Ototoxicity and noise-drug interaction. The Journal of otolaryngology, Volume: 13, Issue: 6	1984
Mechanism of protective effect of fosfomycin against aminoglycoside ototoxicity. Auris, nasus, larynx, Volume: 11, Issue: 3	1984
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Article	Year
Lesion Penetration and Activity Limit the Utility of Second-Line Injectable Agents in Pulmonary Tuberculosis. Antimicrobial agents and chemotherapy, 09-17, Volume: 65, Issue: 10	2021
Dental plaque bacteria with reduced susceptibility to chlorhexidine are multidrug resistant. BMC microbiology, 09-15, Volume: 16	2016
Caspase-independent pathways of hair cell death induced by kanamycin in vivo. Cell death and differentiation, Volume: 13, Issue: 1	2006
Dual action of olivocochlear collaterals in the guinea pig cochlear nucleus. Hearing research, Volume: 174, Issue: 1-2	2002
Hearing loss and nephrotoxicity in long-term aminoglycoside treatment in patients with tuberculosis. The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, Volume: 6, Issue: 7	2002
Effects of chronic administration of kanamycin on the basement membrane anionic sites in the crista ampullaris of guinea pigs. The Laryngoscope, Volume: 108, Issue: 1 Pt 1	1998
[Kanamycin ototoxicity and melanin in the inner ear]. Zhonghua er bi yan hou ke za zhi, Volume: 28, Issue: 1	1993
Kanamycin ototoxicity and pigmentation in the guinea pig. Hearing research, Volume: 3, Issue: 3	1980
[Clinical report of an aged patient with lung abscess who show an excellent response after long-term administration of amikacin (author's transl)]. The Japanese journal of antibiotics, Volume: 35, Issue: 3	1982
Comparative uptake of gentamicin, netilmicin, and amikacin in the guinea pig cochlea and vestibule. Antimicrobial agents and chemotherapy, Volume: 30, Issue: 1	1986
Effects of chronic administration of kanamycin on conditioned suppression to auditory stimulus in rats. Japanese journal of pharmacology, Volume: 26, Issue: 4	1976
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Article	Year
Predicting the Outcomes of New Short-Course Regimens for Multidrug-Resistant Tuberculosis Using Intrahost and Pharmacokinetic-Pharmacodynamic Modeling. Antimicrobial agents and chemotherapy, Volume: 62, Issue: 12	2018
Pharmacokinetics of Second-Line Antituberculosis Drugs after Multiple Administrations in Healthy Volunteers. Antimicrobial agents and chemotherapy, Volume: 59, Issue: 8	2015
Fenestration of the calyx of Held occurs sequentially along the tonotopic axis, is influenced by afferent activity, and facilitates glutamate clearance. The Journal of comparative neurology, May-01, Volume: 514, Issue: 1	2009
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, Volume: 36, Issue: 7	2008
2,3-Dihydroxybenzoic acid attenuates kanamycin-induced volume reduction in mouse utricular type I hair cells. Hearing research, Volume: 212, Issue: 1-2	2006
Successful treatment of a LifeSite Hemodialysis Access System pocket infection with large-volume kanamycin solution irrigation. Advances in renal replacement therapy, Volume: 10, Issue: 3	2003
Serum pharmacokinetics of antimycobacterial drugs in patients with multidrug-resistant tuberculosis during therapy. International journal of clinical pharmacology research, Volume: 19, Issue: 3	1999
Pharmacokinetics of kanamycin in the developing rat. Hearing research, Sep-15, Volume: 99, Issue: 1-2	1996
Quantitative analysis of drug handling by the kidney using a physiological model of renal drug clearance. European journal of clinical pharmacology, Volume: 44, Issue: 6	1993
[Therapy of surgical infections with dibekacin. Pharmacokinetic, clinical and bacteriological results]. Fortschritte der Medizin, Nov-13, Volume: 98, Issue: 42	1980
[Pharmacokinetic interpretation of the myorelaxant effect of kanamycin]. Antibiotiki, Volume: 25, Issue: 5	1980
Amikacin pharmacokinetics in morbidly obese patients. American journal of hospital pharmacy, Volume: 37, Issue: 4	1980
The influence of ascites on the pharmacokinetics of amikacin. International journal of clinical pharmacology, therapy, and toxicology, Volume: 18, Issue: 2	1980
[Kanamycin sulfate pharmacokinetics in the lymph and blood in complicated acute inflammatory diseases of the abdominal cavity organs]. Antibiotiki, Volume: 25, Issue: 3	1980
The pharmacokinetics of some aminoglycoside antibiotics in the horse. Journal of veterinary pharmacology and therapeutics, Volume: 4, Issue: 4	1981
Pharmacokinetics of amikacin in children with normal and impaired renal function. Kidney international, Volume: 20, Issue: 1	1981
[Kanamycin sulfate and sodium cephazolin pharmacokinetics in experimental strangulation obstruction of the small intestine]. Vestnik khirurgii imeni I. I. Grekova, Volume: 127, Issue: 7	1981
Pharmacokinetics of dibekacin in rabbits and dogs. Journal of pharmacobio-dynamics, Volume: 4, Issue: 5	1981
Acute toxicity and pharmacokinetics of dibekacin mice. Journal of pharmacobio-dynamics, Volume: 4, Issue: 5	1981
Amikacin and gentamicin accumulation pharmacokinetics and nephrotoxicity in critically ill patients. Antimicrobial agents and chemotherapy, Volume: 19, Issue: 1	1981
Influence of the route of administration on the pharmacokinetics of amikacin. European journal of clinical pharmacology, Volume: 19, Issue: 5	1981
[Kanamycin pharmacokinetics in experimental small intestine obstruction]. Antibiotiki, Volume: 26, Issue: 3	1981
[Animal experiments on the nephrotoxicity, pharmacokinetics and therapeutic efficacy of dibekacin]. Arzneimittel-Forschung, Volume: 31, Issue: 3	1981
[Pharmacokinetics of dibekacin in patients with chronic renal impairment]. La Nouvelle presse medicale, Nov-18, Volume: 11, Issue: 46	1982
[Pharmacokinetics of dibekacin in subjects with normal renal function]. La Nouvelle presse medicale, Nov-18, Volume: 11, Issue: 46	1982
Influence of intrauterine maturation on the pharmacokinetics of amikacin in the neonatal period. Pediatric research, Volume: 16, Issue: 10	1982
Modification in the pharmacokinetics of amikacin during development. European journal of clinical pharmacology, Volume: 23, Issue: 2	1982
[Pharmacokinetic studies on intravenous drip infusion of dibekacin in elderly subjects without apparent renal failure (author's transl)]. The Japanese journal of antibiotics, Volume: 35, Issue: 3	1982
Aminoglycoside dosing in renal transplant patients. Comparison of nomogram and individualized pharmacokinetic methods in patients with shifting renal function. Annals of surgery, Volume: 195, Issue: 3	1982
The pharmacokinetics and efficacy of an aminoglycoside administered into the cerebral ventricles in neonates: implications for further evaluation of this route of therapy in meningitis. The Journal of infectious diseases, Volume: 143, Issue: 2	1981
Influence of age on amikacin pharmacokinetics in patients without renal disease. Comparison with gentamicin and tobramycin. European journal of clinical pharmacology, Volume: 24, Issue: 5	1983
Influence of type of dialyzer on the pharmacokinetics of amikacin. International journal of clinical pharmacology, therapy, and toxicology, Volume: 21, Issue: 4	1983
Pharmacokinetic studies with dibekacin, a new aminoglycoside, after intravenous and intramuscular administration to human volunteers. Antimicrobial agents and chemotherapy, Volume: 18, Issue: 3	1980
Comparison of standard versus pharmacokinetically adjusted amikacin dosing in granulocytopenic cancer patients. Antimicrobial agents and chemotherapy, Volume: 22, Issue: 2	1982
An effect of fosfomycin on the pharmacokinetics of amikacin. The Journal of antibiotics, Volume: 37, Issue: 4	1984
Effect of infusion time on the pharmacokinetics of dibekacin in rabbits. The Journal of antibiotics, Volume: 37, Issue: 3	1984
Reproducibility study of the pharmacokinetics of amikacin, gentamicin and tobramycin; a three-way crossover study. The Journal of antimicrobial chemotherapy, Volume: 12, Issue: 4	1983
Amikacin sulfate in mares: pharmacokinetics and body fluid and endometrial concentrations after repeated intramuscular administration. American journal of veterinary research, Volume: 45, Issue: 8	1984
Comparative pharmacokinetics of BB-K8 and kanamycin in dogs and humans. Antimicrobial agents and chemotherapy, Volume: 3, Issue: 4	1973
Pharmacokinetics of gentamicin and kanamycin during hemodialysis. Antimicrobial agents and chemotherapy, Volume: 6, Issue: 6	1974
Clinical pharmacokinetics of amikacin in dogs. American journal of veterinary research, Volume: 46, Issue: 8	1985
Pharmacokinetics of amikacin in the horse following intravenous and intramuscular administration. Journal of veterinary pharmacology and therapeutics, Volume: 8, Issue: 2	1985
Pharmacokinetics of dibekacin in children with cystic fibrosis. International journal of clinical pharmacology research, Volume: 5, Issue: 2	1985
Pharmacokinetics of amikacin in pony foals after a single intramuscular injection. American journal of veterinary research, Volume: 47, Issue: 2	1986
Pharmacokinetics of habekacin in patients with renal insufficiency. Antimicrobial agents and chemotherapy, Volume: 31, Issue: 4	1987
[Pharmacokinetics of arbekacin in dogs. I. Serum concentration and urinary excretion]. The Japanese journal of antibiotics, Volume: 40, Issue: 2	1987
[Pharmacokinetics of habekacin in patients with chronic renal insufficiency]. Pathologie-biologie, Volume: 35, Issue: 5 Pt 2	1987
Effect of induced synovial inflammation on pharmacokinetics and synovial concentration of sodium ampicillin and kanamycin sulfate after systemic administration in ponies. Journal of veterinary pharmacology and therapeutics, Volume: 11, Issue: 1	1988
[Clinical study of aminoglycosides on renal dysfunction--pharmacokinetics of arbekacin and its elimination effects by hemodialysis and adsorption with charcoal]. Hinyokika kiyo. Acta urologica Japonica, Volume: 35, Issue: 4	1989
[Pharmacokinetics of arbekacin in healthy volunteers and patients with renal insufficiency]. The Japanese journal of antibiotics, Volume: 42, Issue: 1	1989
[Pharmacokinetics of kanamycin during targeted delivery to the liver in erythrocyte ghosts in animals with experimental acute cholecystitis]. Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], Volume: 35, Issue: 11	1990
Interspecies differences in the pharmacokinetics of kanamycin and apramycin. Veterinary research communications, Volume: 16, Issue: 4	1992
[Clinical pharmacokinetics of kanamycin in endolymphatic therapy of peritonitis]. Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], Volume: 37, Issue: 4	1992
Pharmacokinetics of amikacin for treatment of urinary tract infections in patients with reduced renal function. The Journal of infectious diseases, Volume: 134 SUPPL	1976
Pharmacokinetics of amikacin in patients with impaired renal function. The Journal of infectious diseases, Volume: 134 SUPPL	1976
Pharmacokinetics of amikacin in patients with renal insufficiency: relation of half-life and creatinine clearance. The Journal of infectious diseases, Volume: 134 SUPPL	1976
Pharmacokinetics of amikacin in patients with normal or impaired renal function: radioenzymatic acetylation assay. The Journal of infectious diseases, Volume: 134 SUPPL	1976
Pharmacokinetics and ototoxicity of gentamicin, tobramycin, and amikacin. The Journal of infectious diseases, Volume: 134 Suppl	1976
[Effect of glucocorticoids on the pharmacokinetics of kanamycin in rabbits]. Antibiotiki, Volume: 21, Issue: 7	1976
Pharmacokinetics of dibekacin after intramuscular administration in man. The Japanese journal of antibiotics, Volume: 30, Issue: 9	1977
Effects of gestational age, birth weight, and hypoxemia on pharmacokinetics of amikacin in serum of infants. Antimicrobial agents and chemotherapy, Volume: 11, Issue: 6	1977
Pharmacokinetics of amikacin during hemodialysis and peritoneal dialysis. Antimicrobial agents and chemotherapy, Volume: 11, Issue: 2	1977
Pharmacokinetic and clinical studies with amikacin, a new aminoglycoside antibiotic. The Journal of infectious diseases, Volume: 134 SUPPL	1976
[Pharmacokinetics and clinical experience with amikacin. A new aminoglycoside antibiotic]. Deutsche medizinische Wochenschrift (1946), Sep-03, Volume: 101, Issue: 36	1976
Effects of hypoxemia upon aminoglycoside serum pharmacokinetics in animals. Antimicrobial agents and chemotherapy, Volume: 14, Issue: 3	1978
[Effect of proteolytic enzymes on kanamycin pharmacokinetics in experimental suppurative infection]. Antibiotiki, Volume: 23, Issue: 10	1978
Pharmacokinetic considerations in exchange transfusion in neonates. Clinical pharmacology and therapeutics, Volume: 24, Issue: 1	1978
[Pharmacokinetical, histological, and histochemical investigation on the ototoxicity of gentamicin, tobramycin, and amikacin (author's transl)]. Archives of oto-rhino-laryngology, Jul-29, Volume: 217, Issue: 2	1977
Amikacin pharmacokinetics in pediatric patients with malignancy. Antimicrobial agents and chemotherapy, Volume: 16, Issue: 6	1979
[Fundamental studies of combination of antibiotics, especially on pharmacokinetics. III. Combination of ampicillin and dibekacin (author's transl)]. The Japanese journal of antibiotics, Volume: 32, Issue: 7	1979
Pharmacokinetics of amikacin (BB-K8) in patients undergoing hemodialysis. International journal of clinical pharmacology and biopharmacy, Volume: 17, Issue: 8	1979
Pharmacokinetics of intravenous amikacin after rapid and slow infusion with special reference to hemodialysis. European journal of drug metabolism and pharmacokinetics, Volume: 4, Issue: 1	1979
[Pharmacokinetics of a new aminoglycoside: kanendomycin]. Minerva medica, May-26, Volume: 70, Issue: 25	1979
Pharmacokinetics of Amikacin (BB-K8) in patients with normal or impaired renal function. International journal of clinical pharmacology and biopharmacy, Volume: 17, Issue: 4	1979
Pharmacokinetics of amikacin in infants and pre-school children. Acta paediatrica Scandinavica, Volume: 68, Issue: 3	1979
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

kanamycin a

Description

Cross-References

Synonyms (87)

Actions

Treatment

Roles (1)

Drug Classes (1)

Pathways (1)

Protein Targets (9)

Potency Measurements

Inhibition Measurements

Biological Processes (107)

Molecular Functions (40)

Ceullar Components (41)

Bioassays (1441)

Research

Studies (6,691)

Study Types

Research Highlights

Safety/Toxicity (170)

Long-term Use (11)

Pharmacokinetics (77)

Bioavailability (13)

Dosage (168)

Interactions (18)

Article	Year
Impact of drug-resistant tuberculosis treatment on hearing function in South African adults: Bedaquiline versus kanamycin. The South African journal of communication disorders = Die Suid-Afrikaanse tydskrif vir Kommunikasieafwykings, Jan-26, Volume: 68, Issue: 1	2021
Tuberculosis drugs' distribution and emergence of resistance in patient's lung lesions: A mechanistic model and tool for regimen and dose optimization. PLoS medicine, Volume: 16, Issue: 4	2019
Antibiotics for treating septic abortion. The Cochrane database of systematic reviews, Jul-01, Volume: 7	2016
D-methionine (D-met) significantly reduces kanamycin-induced ototoxicity in pigmented guinea pigs. International journal of audiology, Volume: 55, Issue: 5	2016
Micro-concentration Lipopolysaccharide as a Novel Stimulator of Megakaryocytopoiesis that Synergizes with IL-6 for Platelet Production. Scientific reports, Sep-02, Volume: 5	2015
Limited sampling strategies for therapeutic drug monitoring of amikacin and kanamycin in patients with multidrug-resistant tuberculosis. International journal of antimicrobial agents, Volume: 46, Issue: 3	2015
Pharmacokinetics of Second-Line Antituberculosis Drugs after Multiple Administrations in Healthy Volunteers. Antimicrobial agents and chemotherapy, Volume: 59, Issue: 8	2015
Membrane-Targeting DCAP Analogues with Broad-Spectrum Antibiotic Activity against Pathogenic Bacteria. ACS medicinal chemistry letters, Apr-09, Volume: 6, Issue: 4	2015
Bicarbonate enhances the in vitro antibiotic activity of kanamycin in Escherichia coli. Letters in applied microbiology, Volume: 60, Issue: 5	2015
Role of epidermal growth factor and growth hormone-releasing peptide-6 in acceleration of renal tissue repair after kanamycin overdosing in rats. Iranian journal of kidney diseases, Volume: 8, Issue: 5	2014
Patch-testing for the management of hypersensitivity reactions to second-line anti-tuberculosis drugs: a case report. BMC research notes, Aug-15, Volume: 7	2014
Validated spectrofluorimetric method for determination of selected aminoglycosides. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, Jan-25, Volume: 135	2015
Development of an ototoxicity model in the adult CBA/CaJ mouse and determination of a golden window of corticosteroid intervention for otoprotection. Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale, Apr-24, Volume: 43	2014
Rv3168 phosphotransferase activity mediates kanamycin resistance in Mycobacterium tuberculosis. Journal of microbiology and biotechnology, Nov-28, Volume: 23, Issue: 11	2013
Gold nanorod-covered kanamycin-loaded hollow SiO2 (HSKAu(rod)) nanocapsules for drug delivery and photothermal therapy on bacteria. Nanoscale, Jan-07, Volume: 5, Issue: 1	2013
Protection by low-dose kanamycin against noise-induced hearing loss in mice: dependence on dosing regimen and genetic background. Hearing research, Volume: 280, Issue: 1-2	2011
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, Volume: 16, Issue: 15-16	2011
Chip calorimetry for fast and reliable evaluation of bactericidal and bacteriostatic treatments of biofilms. Antimicrobial agents and chemotherapy, Volume: 54, Issue: 1	2010
A protein derived from the fusion of TAT peptide and FNK, a Bcl-x(L) derivative, prevents cochlear hair cell death from aminoglycoside ototoxicity in vivo. Journal of neuroscience research, May-15, Volume: 85, Issue: 7	2007
Analysis of kanamycin A in human plasma and in oral dosage form by derivatization with 1-naphthyl isothiocyanate and high-performance liquid chromatography. Journal of separation science, Volume: 29, Issue: 5	2006
Aminoglycoside toxicity: daily versus thrice-weekly dosing for treatment of mycobacterial diseases. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Jun-01, Volume: 38, Issue: 11	2004
A set of temperature sensitive-replication/-segregation and temperature resistant plasmid vectors with different copy numbers and in an isogenic background (chloramphenicol, kanamycin, lacZ, repA, par, polA). Gene, Jan-04, Volume: 241, Issue: 1	2000
[Thermophilic bacteria resistant to antibiotics in traditional public baths]. Comparative immunology, microbiology and infectious diseases, Volume: 20, Issue: 4	1997
Cochlear integrity in rats with experimentally induced audiogenic seizure susceptibility. Hearing research, Nov-01, Volume: 101, Issue: 1-2	1996
Disposition kinetics, urinary excretion and dosage regimen of kanamycin in buffalo calves following single intravenous administration. Veterinary research communications, Volume: 17, Issue: 3	1993
Hair cell regeneration in the European starling (Sturnus vulgaris): recovery of pure-tone detection thresholds. Hearing research, Volume: 71, Issue: 1-2	1993
The ototoxicity of 3,3'-iminodipropionitrile: functional and morphological evidence of cochlear damage. Hearing research, Volume: 80, Issue: 2	1994
Regenerated hair cells in the European starling: are they more resistant to kanamycin ototoxicity than original hair cells? Hearing research, Volume: 82, Issue: 2	1995
Comparative ototoxicity of chloramphenicol and kanamycin with ethacrynic acid. Archives of otolaryngology (Chicago, Ill. : 1960), Volume: 107, Issue: 2	1981
Disposition of Dibekacin in patients undergoing haemodialysis. European journal of clinical pharmacology, Volume: 18, Issue: 4	1980
Combined effects of noise and kanamycin. Cochlear pathology and pharmacology. Archives of otolaryngology (Chicago, Ill. : 1960), Volume: 106, Issue: 12	1980
Comparative low-dose nephrotoxicities of gentamicin, tobramycin, and amikacin. Antimicrobial agents and chemotherapy, Volume: 18, Issue: 1	1980
Evaluation of amikacin dosage regimes in the low and very low birthweight newborn. Infection, Volume: 8 Suppl 3	1980
The effects of ototoxicity on the auditory brain stem response and the scalp-recorded cochlear microphonic in guinea pigs. The Laryngoscope, Volume: 90, Issue: 8 Pt 1	1980
The influence of ascites on the pharmacokinetics of amikacin. International journal of clinical pharmacology, therapy, and toxicology, Volume: 18, Issue: 2	1980
The pharmacokinetics of some aminoglycoside antibiotics in the horse. Journal of veterinary pharmacology and therapeutics, Volume: 4, Issue: 4	1981
Kanamycin sulfate in the horse: serum, synovial fluid, peritoneal fluid, and urine concentrations after single-dose intramuscular administration. American journal of veterinary research, Volume: 42, Issue: 10	1981
Urine concentrations of gentamicin, tobramycin, amikacin, and kanamycin after subcutaneous administration to healthy adult dogs. American journal of veterinary research, Volume: 42, Issue: 10	1981
The sensitive period for induction of susceptibility to audiogenic seizures by kanamycin in mice. Archives of oto-rhino-laryngology, Volume: 232, Issue: 3	1981
Pharmacokinetics of amikacin in children with normal and impaired renal function. Kidney international, Volume: 20, Issue: 1	1981
Amikacin and gentamicin accumulation pharmacokinetics and nephrotoxicity in critically ill patients. Antimicrobial agents and chemotherapy, Volume: 19, Issue: 1	1981
The intravenous toxicity of dibekacin sulphate (DKB) to female beagle dogs. The Japanese journal of antibiotics, Volume: 33, Issue: 8	1980
[Animal experiments on the nephrotoxicity, pharmacokinetics and therapeutic efficacy of dibekacin]. Arzneimittel-Forschung, Volume: 31, Issue: 3	1981
[Experimental study of the intrauterine ototoxicity of dibekacin]. La Nouvelle presse medicale, Nov-18, Volume: 11, Issue: 46	1982
Evaluation of the renal and auditory function of neonates treated with amikacin. Developmental pharmacology and therapeutics, Volume: 5, Issue: 1-2	1982
Kanamycin induced ototoxicity in the laboratory rat. A comparative morphological and audiometric study. Archives of toxicology, Volume: 50, Issue: 3-4	1982
Disposition kinetics of amikacin in patients with renal impairment after intramuscular administration. International journal of clinical pharmacology, therapy, and toxicology, Volume: 20, Issue: 6	1982
[Control of serum levels of tobramycin and amikacin during clinical routine treatment conditions (author's transl)]. Deutsche medizinische Wochenschrift (1946), Aug-06, Volume: 107, Issue: 31-32	1982
Selective destruction of the outer hair cells in the chinchilla. Clinical otolaryngology and allied sciences, Volume: 7, Issue: 1	1982
Intraventricular cerebrospinal fluid antibiotic concentrations in patients with intraventricular infections. Neurosurgery, Volume: 10, Issue: 1	1982
Aminoglycoside dosing in renal transplant patients. Comparison of nomogram and individualized pharmacokinetic methods in patients with shifting renal function. Annals of surgery, Volume: 195, Issue: 3	1982
Therapeutic effects of cefotiam and cefazolin on experimental pneumonia caused by Klebsiella pneumoniae DT-S in mice. Antimicrobial agents and chemotherapy, Volume: 18, Issue: 4	1980
Treatment of Klebsiella pneumoniae respiratory tract infection of squirrel monkeys with aerosol administration of kanamycin. American journal of veterinary research, Volume: 41, Issue: 9	1980
Experimental respiratory tract infection with Klebsiella pneumoniae DT-S in mice: chemotherapy with kanamycin. Antimicrobial agents and chemotherapy, Volume: 17, Issue: 3	1980
Influence of age on amikacin pharmacokinetics in patients without renal disease. Comparison with gentamicin and tobramycin. European journal of clinical pharmacology, Volume: 24, Issue: 5	1983
[Therapy of urinary tract infections with dibekacin]. Fortschritte der Medizin, Jan-27, Volume: 101, Issue: 4	1983
Activity of amikacin against Mycobacteria in vitro and in murine tuberculosis. Tubercle, Volume: 63, Issue: 3	1982
Comparison of standard versus pharmacokinetically adjusted amikacin dosing in granulocytopenic cancer patients. Antimicrobial agents and chemotherapy, Volume: 22, Issue: 2	1982
Nebulization for avian respiratory disease. Modern veterinary practice, Volume: 65, Issue: 4	1984
Clinical application of amikacin dosage based upon lean body mass in patients with different renal function. Chemotherapy, Volume: 30, Issue: 2	1984
[Clinical evaluation of ototoxicity associated with intravenous drip infusion of amikacin]. The Japanese journal of antibiotics, Volume: 36, Issue: 10	1983
Quantitation of amikacin, kanamycin, neomycin, and tobramycin in pharmaceutical dosage forms using the Hantzsch reaction. Journal of pharmaceutical sciences, Volume: 72, Issue: 12	1983
Comparison of the nephrotoxicity and auditory toxicity of tobramycin and amikacin. Antimicrobial agents and chemotherapy, Volume: 23, Issue: 6	1983
Comparative study of cefoperazone and amikacin. Clinical therapeutics, Volume: 7, Issue: 1	1984
Colorimetric determination of gentamicin, kanamycin, tobramycin, and amikacin aminoglycosides with 2,4-dinitrofluorobenzene. Journal of pharmaceutical sciences, Volume: 73, Issue: 9	1984
Dissociation of maximum concentration of kanamycin in plasma and perilymph from ototoxic effect. The Journal of antimicrobial chemotherapy, Volume: 14, Issue: 3	1984
Correlation of amikacin concentrations in perilymph and plasma of continuously infused guinea pigs. Antimicrobial agents and chemotherapy, Volume: 26, Issue: 1	1984
Amikacin sulfate in mares: pharmacokinetics and body fluid and endometrial concentrations after repeated intramuscular administration. American journal of veterinary research, Volume: 45, Issue: 8	1984
The key role of aminoglycosides in antibacterial therapy and prophylaxis. The Journal of antimicrobial chemotherapy, Volume: 13 Suppl A	1984
[Experimental study on renal tolerability of aminoglycosides butirosin and bekanamycin (author's transl)]. Arzneimittel-Forschung, Volume: 30, Issue: 2	1980
[Kinetics of multiple-dose amikacin in the newborn infant]. Annales de l'anesthesiologie francaise, Volume: 22, Issue: 2	1981
[Serial measurement of serum levels of amikacin. Value in therapy]. Annales de l'anesthesiologie francaise, Volume: 22, Issue: 2	1981
Use of phenotypic suppression for direct selection of loss of aminoglycoside antibiotic resistance determinants. Molecular & general genetics : MGG, Volume: 196, Issue: 2	1984
Enhancement of antibiotic activity against Staphylococcus aureus by exposure to hyperbaric oxygen. Applied microbiology, Volume: 15, Issue: 5	1967
Treatment of chronic urinary tract infections with gentamicin. Journal of clinical pathology, Volume: 20, Issue: 5	1967
Comparative pharmacokinetics of BB-K8 and kanamycin in dogs and humans. Antimicrobial agents and chemotherapy, Volume: 3, Issue: 4	1973
Pharmacokinetics of gentamicin and kanamycin during hemodialysis. Antimicrobial agents and chemotherapy, Volume: 6, Issue: 6	1974
[Fundamental and clinical studies on intravenous drip infusion of dibekacin in the pediatric field]. The Japanese journal of antibiotics, Volume: 38, Issue: 8	1985
Effects of ambient temperature on the half-life and dosage regimen of amikacin in the gopher snake. Journal of the American Veterinary Medical Association, Dec-01, Volume: 187, Issue: 11	1985
Nephrotoxicity of aminoglycosides in young and adult rats. Pediatric research, Volume: 19, Issue: 11	1985
Clinical pharmacokinetics of amikacin in dogs. American journal of veterinary research, Volume: 46, Issue: 8	1985
Amikacin therapy for Pseudomonas cellulitis in an Amazon parrot. Journal of the American Veterinary Medical Association, Aug-15, Volume: 187, Issue: 4	1985
Pharmacokinetics of amikacin in the horse following intravenous and intramuscular administration. Journal of veterinary pharmacology and therapeutics, Volume: 8, Issue: 2	1985
Pharmacokinetics of dibekacin in children with cystic fibrosis. International journal of clinical pharmacology research, Volume: 5, Issue: 2	1985
Effect of pentobarbital anesthesia on amikacin concentrations in plasma and perilymph and evaluation of multiple sampling in perilymph of guinea pigs. Antimicrobial agents and chemotherapy, Volume: 27, Issue: 5	1985
Effect of peritoneal dialysis on serum concentrations of three drugs commonly used in pediatric patients. Developmental pharmacology and therapeutics, Volume: 8, Issue: 2	1985
Pharmacokinetics of amikacin in pony foals after a single intramuscular injection. American journal of veterinary research, Volume: 47, Issue: 2	1986
[Present-day aminoglycosides in the treatment of suppurative-septic diseases]. Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology, Volume: 30, Issue: 1	1985
Antibacterial activity and ototoxicity in guinea pigs, and nephrotoxicity in rats of arbekacin. Arzneimittel-Forschung, Volume: 36, Issue: 10	1986
Efficacy of single-agent therapy with azlocillin, ticarcillin, and amikacin and beta-lactam/amikacin combinations for treatment of Pseudomonas aeruginosa bacteremia in granulocytopenic rats. The American journal of medicine, May-30, Volume: 80, Issue: 5C	1986
Effect of mode of administration on distribution of dibekacin in rabbits. The Journal of antimicrobial chemotherapy, Volume: 19, Issue: 6	1987
Further studies of the killing of M. leprae by aminoglycosides: reduced dosage and frequency of administration. International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, Volume: 55, Issue: 1	1987
Aminoglycoside toxicity in infants and children. The American journal of medicine, Jun-30, Volume: 80, Issue: 6B	1986
The sensitive period and optimum dosage for induction of audiogenic seizure susceptibility by kanamycin in the Wistar rat. Hearing research, Volume: 32, Issue: 1	1988
[Habekacin: a new aminoglycoside. Study of nephrotoxicity in rats in comparison with gentamicin, netilmicin and amikacin]. Pathologie-biologie, Volume: 36, Issue: 6	1988
In vivo efficacy of azlocillin and amikacin versus ciprofloxacin with and without amikacin in experimental right-sided endocarditis due to Pseudomonas aeruginosa. Chemotherapy, Volume: 32, Issue: 4	1986
Enzymuria in aminoglycoside-induced kidney damage. Comparative study of gentamicin, amikacin, sisomicin and netilmicin. International journal of clinical pharmacology research, Volume: 5, Issue: 5	1985
[Experimental study of drug-induced acute renal failure. Recovery after renal impairment caused by the administration of low molecular weight dextran and kanamycin in water-deprived rats]. Hinyokika kiyo. Acta urologica Japonica, Volume: 34, Issue: 2	1988
Treatment of Brucella canis and Brucella abortus in vitro and in vivo by stable plurilamellar vesicle-encapsulated aminoglycosides. The Journal of infectious diseases, Volume: 152, Issue: 3	1985
Circadian rhythm dependent kanamycin-induced hearing loss in rodents assessed by auditory brainstem responses. Acta oto-laryngologica, Volume: 111, Issue: 6	1991
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Description	Relationhip Strength	Studies	Trials	Classes	Roles
carbenicillin	[no description available]	medium	177	0	penicillin allergen; penicillin	antibacterial drug
carbenicillin	[no description available]	medium	177	6	penicillin allergen; penicillin	antibacterial drug
tobramycin	[no description available]	medium	296	0	amino cyclitol glycoside	antibacterial agent; antimicrobial agent; toxin
tobramycin	[no description available]	medium	296	12	amino cyclitol glycoside	antibacterial agent; antimicrobial agent; toxin
gentamicin c1	[no description available]	medium	4	0
isoniazid	[no description available]	medium	293	0	carbohydrazide	antitubercular agent; drug allergen
isoniazid	[no description available]	medium	293	3	carbohydrazide	antitubercular agent; drug allergen
ethambutol	[no description available]	medium	175	0	ethanolamines; ethylenediamine derivative	antitubercular agent; environmental contaminant; xenobiotic
ethambutol	[no description available]	medium	175	7	ethanolamines; ethylenediamine derivative	antitubercular agent; environmental contaminant; xenobiotic
2,2'-dithiobis(n-2-hydroxypropylbenzamide)	[no description available]	medium	1	0
rifampin	[no description available]	medium	297	0	cyclic ketal; hydrazone; N-iminopiperazine; N-methylpiperazine; rifamycins; semisynthetic derivative; zwitterion	angiogenesis inhibitor; antiamoebic agent; antineoplastic agent; antitubercular agent; DNA synthesis inhibitor; EC 2.7.7.6 (RNA polymerase) inhibitor; Escherichia coli metabolite; geroprotector; leprostatic drug; neuroprotective agent; pregnane X receptor agonist; protein synthesis inhibitor
rifampin	[no description available]	medium	297	4	cyclic ketal; hydrazone; N-iminopiperazine; N-methylpiperazine; rifamycins; semisynthetic derivative; zwitterion	angiogenesis inhibitor; antiamoebic agent; antineoplastic agent; antitubercular agent; DNA synthesis inhibitor; EC 2.7.7.6 (RNA polymerase) inhibitor; Escherichia coli metabolite; geroprotector; leprostatic drug; neuroprotective agent; pregnane X receptor agonist; protein synthesis inhibitor
amikacin	[no description available]	medium	926	0	alpha-D-glucoside; amino cyclitol glycoside; aminoglycoside; carboxamide	antibacterial drug; antimicrobial agent; nephrotoxin
amikacin	[no description available]	medium	926	64	alpha-D-glucoside; amino cyclitol glycoside; aminoglycoside; carboxamide	antibacterial drug; antimicrobial agent; nephrotoxin
netilmicin	[no description available]	medium	67	0
netilmicin	[no description available]	medium	67	5
isepamicin	[no description available]	medium	12	0
aminosalicylic acid	[no description available]	medium	78	0	aminobenzoic acid; phenols	antitubercular agent
aminosalicylic acid	[no description available]	medium	78	2	aminobenzoic acid; phenols	antitubercular agent
streptomycin	[no description available]	high	1,373	7	antibiotic antifungal drug; antibiotic fungicide; streptomycins	antibacterial drug; antifungal agrochemical; antimicrobial agent; antimicrobial drug; bacterial metabolite; protein synthesis inhibitor
streptomycin	[no description available]	high	1,373	0	antibiotic antifungal drug; antibiotic fungicide; streptomycins	antibacterial drug; antifungal agrochemical; antimicrobial agent; antimicrobial drug; bacterial metabolite; protein synthesis inhibitor
ethionamide	[no description available]	medium	220	0	pyridines; thiocarboxamide	antilipemic drug; antitubercular agent; fatty acid synthesis inhibitor; leprostatic drug; prodrug
ethionamide	[no description available]	medium	220	5	pyridines; thiocarboxamide	antilipemic drug; antitubercular agent; fatty acid synthesis inhibitor; leprostatic drug; prodrug
nalidixic acid	[no description available]	medium	154	0	1,8-naphthyridine derivative; monocarboxylic acid; quinolone antibiotic	antibacterial drug; antimicrobial agent; DNA synthesis inhibitor
sulfanilamide	[no description available]	medium	8	0	substituted aniline; sulfonamide antibiotic; sulfonamide	antibacterial agent; drug allergen; EC 4.2.1.1 (carbonic anhydrase) inhibitor
chloramphenicol	[no description available]	medium	914	0	C-nitro compound; carboxamide; diol; organochlorine compound	antibacterial drug; antimicrobial agent; Escherichia coli metabolite; geroprotector; Mycoplasma genitalium metabolite; protein synthesis inhibitor
chloramphenicol	[no description available]	medium	914	5	C-nitro compound; carboxamide; diol; organochlorine compound	antibacterial drug; antimicrobial agent; Escherichia coli metabolite; geroprotector; Mycoplasma genitalium metabolite; protein synthesis inhibitor
cephalothin	[no description available]	medium	243	0	azabicycloalkene; beta-lactam antibiotic allergen; carboxylic acid; cephalosporin; semisynthetic derivative; thiophenes	antibacterial drug; antimicrobial agent
cephalothin	[no description available]	medium	243	5	azabicycloalkene; beta-lactam antibiotic allergen; carboxylic acid; cephalosporin; semisynthetic derivative; thiophenes	antibacterial drug; antimicrobial agent
erythromycin	[no description available]	medium	428	0	cyclic ketone; erythromycin
erythromycin	[no description available]	medium	428	6	cyclic ketone; erythromycin
vancomycin	[no description available]	high	163	0	glycopeptide	antibacterial drug; antimicrobial agent; bacterial metabolite
amoxicillin	[no description available]	medium	34	0	penicillin allergen; penicillin	antibacterial drug
streptogramin b	[no description available]	medium	1	0	cyclodepsipeptide	antibacterial drug; antimicrobial agent; bacterial metabolite
penicillin g sodium	[no description available]	medium	1	0	organic sodium salt
tetracycline	[no description available]	medium	908	0
tetracycline	[no description available]	medium	908	5
ketoconazole	[no description available]	medium	19	0	dichlorobenzene; dioxolane; ether; imidazoles; N-acylpiperazine; N-arylpiperazine
penicillin g	[no description available]	medium	243	0	penicillin allergen; penicillin	antibacterial drug; drug allergen; epitope
penicillin g	[no description available]	medium	243	4	penicillin allergen; penicillin	antibacterial drug; drug allergen; epitope

kanamycin a

Description

Cross-References

Synonyms (87)

Actions

Treatment

Roles (1)

Drug Classes (1)

Pathways (1)

Protein Targets (9)

Potency Measurements

Inhibition Measurements

Biological Processes (107)

Molecular Functions (40)

Ceullar Components (41)

Bioassays (1441)

Research

Studies (6,691)

Study Types

Related Drugs (3,091)

Related Conditions (3,843)

Research Highlights

Safety/Toxicity (170)

Long-term Use (11)

Pharmacokinetics (77)

Bioavailability (13)

Dosage (168)

Interactions (18)