Kanamycin: Antibiotic complex produced by Streptomyces kanamyceticus from Japanese soil. Comprises 3 components: kanamycin A, the major component, and kanamycins B and C, the minor components. [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
kanamycin : Kanamycin is a naturally occurring antibiotic complex from Streptomyces kanamyceticus that consists of several components: kanamycin A, the major component (also usually designated as kanamycin), and kanamycins B, C, D and X the minor components. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| ID Source | ID |
|---|---|
| PubMed CID | 6032 |
| CHEMBL ID | 1384 |
| CHEBI ID | 17630 |
| CHEBI ID | 6104 |
| SCHEMBL ID | 2735 |
| MeSH ID | M0011918 |
| Synonym |
|---|
| bdbm50031282 |
| (1s,2r,3r,4s,6r)-4,6-diamino-3-(6-amino-6-deoxy-alpha-d-glucopyranosyloxy)-2-hydroxycyclohexyl 3-amino-3-deoxy-alpha-d-glucopyranoside |
| CHEBI:17630 , |
| 4,6-diamino-2-hydroxy-1,3-cyclohexylene 3,6'-diamino-3,6'-dideoxydi-d-glucopyranoside |
| 4,6-diamino-2-hydroxy-1,3-cyclohexane 3,6'diamino-3,6'-dideoxydi-alpha-d-glucoside |
| o-3-amino-3-deoxy-alpha-d-glucopyranosyl-(1->6)-o-(6-amino-6-deoxy-alpha-d-glucopyranosyl-(1->4))-2-deoxy-d-streptamine |
| KBIO1_000024 |
| DIVK1C_000024 |
| (1s,2r,3r,4s,6r)-4,6-diamino-3-[(6-amino-6-deoxy-alpha-d-glucopyranosyl)oxy]-2-hydroxycyclohexyl 3-amino-3-deoxy-alpha-d-glucopyranoside |
| BPBIO1_000669 |
| PRESTWICK3_000394 |
| NCGC00179506-01 |
| (2r,3s,4s,5r,6r)-2-(aminomethyl)-6-[(1r,2r,3s,4r,6s)-4,6-diamino-3-[(2s,3r,4s,5s,6r)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-2-hydroxy-cyclohexoxy]tetrahydropyran-3,4,5-triol |
| liposomal kanamycin |
| kantrex (1:1 sulfate) |
| klebcil (1:1 sulfate) |
| o-3-amino-3-deoxy-.alpha.-d-glucopyranosyl-(1->6)-o-[6-amino-6-deoxy-.alpha.-d-glucopyranosyl-(1->4)]-2-deoxy-d-streptamine |
| KAN , |
| SMP2_000007 |
| BSPBIO_000607 |
| AB00513827 |
| kanamycin a |
| 8063-07-8 |
| C01822 |
| kanamycin |
| 59-01-8 |
| DB01172 |
| IDI1_000024 |
| NINDS_000024 |
| d-streptamine, o-3-amino-3-deoxy-alpha-d-glucopyranosyl-(1-6)-o-(6-amino-6-deoxy-alpha-d-glucopyranosyl-(1,4))-2-deoxy- |
| hsdb 3107 |
| kanamycine [inn-french] |
| kanamicina [italian] |
| glucopyranoside, 4,6-diamino-2-hydroxy-1,3-cyclohexylene 3,6'-diamino-3,6'-dideoxydi-, d- |
| km (the antibiotic) |
| kanamycinum [inn-latin] |
| d-streptamine, o-3-amino-3-deoxy-alpha-d-glucopyranosyl-(1-6)-o-(6-amino-6-deoxy-alpha-d-glucopyranosyl-(1-4))-2-deoxy- |
| brn 0061647 |
| kanamycin [inn:ban] |
| einecs 200-411-7 |
| CHEMBL1384 |
| kanamycins , |
| (2r,3s,4s,5r,6r)-2-(aminomethyl)-6-[(1r,2r,3s,4r,6s)-4,6-diamino-3-[(2s,3r,4s,5s,6r)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxyoxane-3,4,5-triol |
| 2-(aminomethyl)-6-[4,6-diamino-3-[4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxyoxane-3,4,5-triol |
| unii-eqk9q303c5 |
| eqk9q303c5 , |
| d-streptamine, o-3-amino-3-deoxy-alpha-d-glucopyranosyl-(1->6)-o-(6-amino-6-deoxy-alpha-d-glucopyranosyl-(1->4))-2-deoxy- |
| d-streptamine, o-3-amino-3-deoxy-alpha-d-glucopyranosyl-(1.fwdarw.6)-o-(6-amino-6-deoxy-alpha-d-glucopyranosyl-(1.fwdarw.4))-2-deoxy- |
| kanamycine |
| kanamicina |
| kanamycinum |
| kanamycin base |
| einecs 232-512-7 |
| unii-ruc37xup2p |
| ruc37xup2p , |
| K-0250 |
| kanamycin a [who-ip] |
| d-streptamine, o-3-amino-3-deoxy-.alpha.-d-glucopyranosyl-(1->6)-o-(6-amino-6-deoxy-.alpha.-d-glucopyranosyl-(1->4))-2-deoxy- |
| kanamycin a [hsdb] |
| kanamycin a [mi] |
| BRD-K08327065-065-01-9 |
| antibiotic complex from streptomyces kanamyceticus containing kanamycin a (major), kanamycin b and kanamycin c |
| d-streptamine, o-3-amino-3-deoxy-.alpha.-d-glucopyranosyl-(1.fwdarw.6)-o-[6-amino-6-deoxy-.alpha.-d-glucopyranosyl-(1.fwdarw.4)]-2-deoxy- |
| SCHEMBL2735 |
| SBUJHOSQTJFQJX-NOAMYHISSA-N |
| CHEBI:6104 , |
| AKOS025293505 |
| kanamycin sulfate, antibiotic for culture media use only |
| DTXSID3023184 , |
| (2r,3s,4s,5r,6r)-2-(aminomethyl)-6-{[(1r,2r,3s,4r,6s)-4,6-diamino-3-{[(2s,3r,4s,5s,6r)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-2-hydroxycyclohexyl]oxy}oxane-3,4,5-triol |
| kanamycin,(s) |
| (2r,3s,4s,5r,6r)-2-(aminomethyl)-6-((1r,2r,3s,4r,6s)-4,6-diamino-3-((2s,3r,4s,5s,6r)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2h-pyran-2-yloxy)-2-hydroxycyclohexyloxy)tetrahydro-2h-pyran-3,4,5-triol |
| Q27094615 |
| AS-14003 |
| NCGC00179506-05 |
| kanamycina |
| gtpl12132 |
| CS-0006792 |
| HY-16566 |
| DTXSID2041171 , |
| EN300-19735925 |
| s01aa24 |
| kanamycinum (latin) |
| kanamycin complex |
| a07aa08 |
| j01gb04 |
| dtxcid503184 |
| Excerpt | Reference | Relevance |
|---|---|---|
| "Bekanamycin at a lower concentration than that needed to induce electrophysiological effects potentiated verapamil 1 x 10(-8) effects on cardiac pacemaker cells." | ( Effects of bekanamycin and dibekacin on the electrical activity of cardiac pacemaker cells. Castrillon, JL; Hernandez, DA; Morales, MA, 1993) | 1.21 |
| Excerpt | Reference | Relevance |
|---|---|---|
| "The treatment with kanamycin alone resulted in a 2.6-fold increase in the number of the antibiotic-resistant variants in the microbial populations of the wounds." | ( [Prevention of the formation of drug resistance in bacterial populations by using biologically active substances]. Afinogenov, GE; Briantseva, LN; Kopylova, TV; Vladimirov, NI, 1984) | 0.59 |
Morphologic study of the medial basilar papilla disclosed that both kanamycin and netilmicin are toxic to the hair cells in this region. Second-line injectable antituberculosis medications cause important adverse effects including permanent sensorineural hearing loss, nephrotoxicity, electrolyte abnormalities and local injection site complications.
| Excerpt | Reference | Relevance |
|---|---|---|
| " Severe pathologic conditions, over-dosage, or concomitant exposure to other potent drugs may predispose a patient to these acute adverse effects." | ( Acute adverse effects of antibiotics. Adams, HR, 1975) | 0.25 |
| "Animal experiments showed that all aminoglycosides cause similar toxic tubular and glomerular damage when investigated by qualitative morphology." | ( [Side effects of aminoglycosides: nephrotoxicity (author's transl)]. Beck, H; Freiesleben, H; Sack, K; Schulz, E; Züllich, B, 1976) | 0.26 |
| " Amikacin causes the most pronounced physiological damage observed by the early loss of Preyer reflex and general toxic signs--these observations correspond with the morphological findings." | ( [Animal experiments concerning the neurotoxicity of aminoglycosid antibiotics. Electron microscopic findings regarding dose--depending mitochondrial damage in the cochlear nucleus of the guinea pig (author's transl)]. Theopold, HM, 1976) | 0.26 |
| "The hockey stick regression method is a convenient method to estimate safe doses, which is a kind of regression method using segmented lines." | ( Estimation of safe doses: critical review of the hockey stick regression method. Yamamoto, E; Yanagimoto, T, 1979) | 0.26 |
| " The toxic threshold doses were found to be within the range of human therapeutic dosages: amikacin: 10 mg/kg/day, kanamycin: 5 mg/kg/day." | ( [Amikacin and kanamycin. Comparative experimental studies on nephrotoxicity]. Sack, K; Züllich, B, 1978) | 0.26 |
| " Decreased tubular resorption of glucose and phosphate were observed with the most toxic regimens after extensive renal damage had occurred." | ( Comparative nephrotoxicity of aminoglycoside antibiotics in rats. Bloch, R; Costello, R; Luft, FC; Maxwell, DR; Sloan, RS; Yum, MN, 1978) | 0.26 |
| "It was the purpose of this study to establish criteria for use in comparing the toxic effects of aminoglycosid antibiotics on the organ of Corti by means of scanning electron microscopy." | ( Comparative surface studies of ototoxic effects of various aminoglycoside antibiotics on the organ of Corti in the guinea pig. A scanning electron microscopic study. Theopold, HM, ) | 0.13 |
| " The result or examination of the guinea pigs received BB-K8 at 40 mg/kg and 100 mg/kg respectively for 28 days suggests that BB-K8 at expecting clinical dose, 500 mg per day (for 28 days) may be safe from ototoxicosis in the inner ears." | ( [Evaluation of ototoxicity of amikacin (BB-K8) by animal test (author's transl)]. Akiyoshi, M; Nakada, H; Sato, K; Suzuki, K; Tajima, T, 1975) | 0.25 |
| "Guinea pigs receiving intramuscular kanamycin sulfate 400 mg/kg daily and thyroxin 10 mg/kg orally every other day for 9 days were studied to determine whether thyroxin prevents toxic damage to the cochlea from kanamycin." | ( The prophylactic effect of thyroxin on kanamycin ototoxicity in guinea pigs. Din, D; Hangfu, M; Zhao, J, 1992) | 0.28 |
| " Ototoxicity occurred in six (11 percent) of the 54 gentamicin-treated patients; auditory toxicity occurred in three patients, and toxic changes were observed in three of the 33 patients who could also be evaluated for vestibular toxicity." | ( Comparative study of ototoxicity and nephrotoxicity in patients randomly assigned to treatment with amikacin or gentamicin. Lerner, SA; Matz, GJ; Schmitt, BA; Seligsohn, R, 1986) | 0.27 |
| " However, the aminoglycosides displayed marked differences in the threshold dose required to produce toxic reactions, permitting the following ordering of toxicity: (most toxic) gentamicin greater than netilmicin = tobramycin greater than amikacin = kanamycin (least toxic)." | ( Comparative toxicity of intravitreal aminoglycoside antibiotics. Caspers-Velu, L; D'Amico, DJ; Hanninen, LA; Kenyon, KR; Libert, J; Schrooyen, M; Shanks, E, 1985) | 0.27 |
| " We evaluated possible potentiation of the toxic effects of CSP and kanamycin compared with CSP alone in the inner ear and kidney and quantitatively localized CSP in the cochlea with gamma emission analysis of 195mPt." | ( Ototoxic and nephrotoxic effects of combined treatment with cis-diamminedichloroplatinum and kanamycin in the guinea pig. Abrams, G; Christy, M; Davis, JA; Hawkins, JE; Lilly, DJ; Litterst, CJ; Schweitzer, VG, 1984) | 0.27 |
| " We conclude that the nephrotoxicity and auditory toxicity of amikacin and tobramycin are not significantly different and that such toxicities are indeed infrequent events when the dosages of these drugs are adjusted to hold blood levels within the safe boundaries suggested by the studies of others." | ( Comparison of the nephrotoxicity and auditory toxicity of tobramycin and amikacin. Araujo, V; Ballesta, A; Bohé, M; Bonet, M; Elena, M; Farré, M; Gatell, JM; Jimenez de Anta, MT; Marin, JL; San Miguel, JG; Zamora, L, 1983) | 0.27 |
| " We suggest that the pharmacokinetic advantages of amikacin in comparison to gentamicin might be of practical importance in the prediction of serum levels thereby lowering the risk of toxic reactions." | ( A prospective, randomized study of amikacin and gentamicin in serious infections with focus on efficacy, toxicity and duration of serum levels above the MIC. Hill, B; Holm, SE; Löwestad, A; Maller, R; Vikerfors, T, 1983) | 0.27 |
| " Using stepwise discriminant analysis, we selected these factors with liver dysfunction and the serum urea nitrogen:serum creatinine ratio in a function that accurately discriminates between toxic and nontoxic patients." | ( Risk factors for the development of auditory toxicity in patients receiving aminoglycosides. Lietman, PS; Moore, RD; Smith, CR, 1984) | 0.27 |
| " Morphologic study of the medial basilar papilla disclosed that both kanamycin and netilmicin are toxic to the hair cells in this region." | ( Aminoglycoside ototoxicity in the chick (Gallus domesticus) inner ear: I. The effects of kanamycin and netilmicin on the basilar papilla. Fermin, CD; Igarashi, M, ) | 0.59 |
| "The adverse effects of drugs which caused changes in therapeutic regimens have been studied in 511 patients with pulmonary tuberculosis, at the Pavilion Koch of Buenos Aires University." | ( Adverse effects of antituberculosis drugs causing changes in treatment. Dambrosi, A; Dambrosi, VM; Gonzalez Montaner, LJ; Manassero, M, 1982) | 0.26 |
| "The antibiotic spectrum, pharmacology, adverse effects, and therapeutic use of amikacin sulfate are reviewed." | ( Antimicrobial spectrum, pharmacology, adverse effects, and therapeutic use of amikacin sulfate. Ho, PW; Pien, FD, 1981) | 0.26 |
| " Renal toxic effects were detected in two children (9." | ( Renal and Auditory toxic effects of amikacin in children with cancer. Deshpande, G; Faden, H; Grossi, M, 1982) | 0.26 |
| " In any dogs, the adverse findings were mainly observed in the renal proximal tubules but not in the glomeruli." | ( [Toxicological study of amikacin following intravenous drip infusion. 2. Subacute toxicity in dogs after intravenous injection]. Akutsu, S; Asano, M; Fukushima, Y; Komatsu, H; Matsumoto, H; Matsuzaki, M; Samura, K; Shimamura, T, 1982) | 0.26 |
| " The results of this study indicated that hydroxygentamicin may be tolerated better than gentamicin in the guinea pig and therefore warrants further development as a new and less toxic aminoglycosidic antibiotic." | ( The ototoxicity of hydroxygentamicin, a new aminoglycoside antibiotic, in guinea pigs. Drobeck, HP; Hawkins, JE; Liddell, MR; Montenaro, MJ; Neidl, MJ, ) | 0.13 |
| "The LD50 values of dibekacin to mice were determined following three different methods of administration, namely, intravenous constant infusion, intravenous bolus injection, and intramuscular injection." | ( Acute toxicity and pharmacokinetics of dibekacin mice. Fujita, M; Kikai, S; Komiya, I; Murata, S; Tomono, N; Umemura, K, 1981) | 0.26 |
| " The well known ototoxicity of neomycin was observed and RU 25434 appeared to be relatively less toxic than amikacin." | ( Comparative ototoxic effects of RU 25434, amikacin and neomycin in guinea-pigs. Boissier, JR; Dumont, C; N'guyen, P, 1980) | 0.26 |
| " (5) Judging from the above-mentioned results, "the maximal non toxic dose" through the intraperitoneal administration to rats of this drug was assumed 20 mg/kg in either sex." | ( [Toxicological studies on dibekacin for intravenous injection use. I. Subacute toxicity in rats and rabbits (author's transl)]. Hirano, F; Ishiwatari, N; Kawaoto, H; Koeda, T; Kumagai, K; Niizato, T; Odaki, M; Sasaki, H; Suzuki, H; Watanabe, H; Watanuki, T; Yokota, M, 1980) | 0.26 |
| "The toxic effects of dibekacin sulfate (DKB) in male and female rats were examined in chronic toxicity test (intraperitoneal injection), and the following results were obtained." | ( [Toxicological studies on dibekacin for intravenous injection use. II. Chronic toxicity in rats (author's transl)]. Hirano, F; Ishiwatari, N; Kawaoto, H; Koeda, T; Niizato, T; Odaki, M; Sasaki, H; Senoo, A; Watanabe, H; Watanuki, T; Yokota, M, 1980) | 0.26 |
| "Chloramphenicol is not ototoxic if administered for systemic effect, but topical applications of it to the middle ear produce severe cochlear toxic effects." | ( Comparative ototoxicity of chloramphenicol and kanamycin with ethacrynic acid. Asakuma, S; Beaugard, ME; Snow, JB, 1981) | 0.26 |
| " This study supports the idea that iron and free radicals play a critical role in the toxic side effects of aminoglycoside antibiotics." | ( Iron chelators protect from aminoglycoside-induced cochleo- and vestibulo-toxicity. Schacht, J; Sha, SH; Song, BB, 1998) | 0.3 |
| " The mechanisms by which aminoglycosides cause auditory dysfunction are still being unraveled, but likely include the following: 1) penetration into the endolymphatic fluid of the scala media, 2) permeation of nonselective cation channels on the apical surface of hair cells, and 3) generation of toxic reactive oxygen species and interference with other cellular pathways." | ( Synergistic ototoxicity due to noise exposure and aminoglycoside antibiotics. Li, H; Steyger, PS, ) | 0.13 |
| "Hearing and balance receptors in the inner ear are highly susceptible to damage caused by a wide variety of toxic substances, including aminoglycosides." | ( Comparison of different aminoglycoside antibiotic treatments to refine ototoxicity studies in adult mice. Cediel, R; Contreras, J; Murillo-Cuesta, S; Varela-Nieto, I, 2010) | 0.36 |
| " Rasagiline, with its multi-target action and favorable adverse effects profile, might be a good candidate for a clinical trial testing the otoprotective indication." | ( Protective effect of rasagiline in aminoglycoside ototoxicity. Aller, M; Andó, R; Harnos, A; Horváth, T; Humli, V; Polony, G; Tamás, L; Vizi, ES; Zelles, T, 2014) | 0.4 |
| "Aminoglycoside antibiotics are highly effective agents against gram-negative bacterial infections, but they cause adverse effects on hearing and balance dysfunction as a result of toxicity to hair cells of the cochlea and vestibular organs." | ( Systemic lipopolysaccharide induces cochlear inflammation and exacerbates the synergistic ototoxicity of kanamycin and furosemide. Hirose, K; Li, SZ; Ohlemiller, KK; Ransohoff, RM, 2014) | 0.62 |
| " 17-DMAG has the possibility to be a safe and effective anti-ototoxic drug." | ( 17-DMAG induces Hsp70 and protects the auditory hair cells from kanamycin ototoxicity in vitro. Bing, D; Chen, J; Chen, Q; Chu, H; Cui, Y; Liu, Y; Pan, C; Sun, Y; Wang, S; Yu, Y; Zhou, L, 2015) | 0.42 |
| "Many adverse drug reactions are caused by the cytochrome P450 (CYP)-dependent activation of drugs into reactive metabolites." | ( Development of a cell viability assay to assess drug metabolite structure-toxicity relationships. Jones, LH; Nadanaciva, S; Rana, P; Will, Y, 2016) | 0.43 |
| " Adverse events associated with second-line drugs (SLDs) can have severe impact on efficient management." | ( Frequency of adverse events observed with second-line drugs among patients treated for multidrug-resistant tuberculosis. Hosmane, GB; Jain, A; Kushwaha, RA; Prasad, R; Singh, A; Srivastava, R, 2016) | 0.43 |
| "To know the frequency of adverse events due to SLDs in patients of MDR-TB." | ( Frequency of adverse events observed with second-line drugs among patients treated for multidrug-resistant tuberculosis. Hosmane, GB; Jain, A; Kushwaha, RA; Prasad, R; Singh, A; Srivastava, R, 2016) | 0.43 |
| " Adverse events associated with treatment were recognized primarily by clinical evidence and/or laboratory investigations that were advised at baseline and whenever clinically indicated during course of treatment." | ( Frequency of adverse events observed with second-line drugs among patients treated for multidrug-resistant tuberculosis. Hosmane, GB; Jain, A; Kushwaha, RA; Prasad, R; Singh, A; Srivastava, R, 2016) | 0.43 |
| "119 adverse events were reported in 46 (46." | ( Frequency of adverse events observed with second-line drugs among patients treated for multidrug-resistant tuberculosis. Hosmane, GB; Jain, A; Kushwaha, RA; Prasad, R; Singh, A; Srivastava, R, 2016) | 0.43 |
| "MDR-TB can be cured successfully with appropriate combination of drugs if adverse events associated with them can be managed aggressively and timely." | ( Frequency of adverse events observed with second-line drugs among patients treated for multidrug-resistant tuberculosis. Hosmane, GB; Jain, A; Kushwaha, RA; Prasad, R; Singh, A; Srivastava, R, 2016) | 0.43 |
| " The second-line injectable antituberculosis medications amikacin, kanamycin and capreomycin, traditionally a mainstay of MDR-TB treatment, cause important adverse effects including permanent sensorineural hearing loss, nephrotoxicity, electrolyte abnormalities, injection pain and local injection site complications." | ( The safety and tolerability of the second-line injectable antituberculosis drugs in children. Garcia-Prats, AJ; Hesseling, AC; Schaaf, HS, 2016) | 0.67 |
| "Nephrotoxicity and ototoxicity are clinically significant dose-related adverse effects associated with second-line anti-tubercular injectables drugs (aminoglycosides and capreomycin) used during intensive phase of treatment of multi-drug resistant tuberculosis (MDR-TB) patients." | ( Nephrotoxicity and ototoxic symptoms of injectable second-line anti-tubercular drugs among patients treated for MDR-TB in Ethiopia: a retrospective cohort study. Admasu, A; Berha, AB; Negash, Z; Sheth, AN; Shibeshi, W; Yimer, G, 2019) | 0.51 |
| " Based on laboratory criteria (serum creatinine), nephrotoxicity remained significant adverse events throughout intensive phase of treatment, indicating close monitoring of patients for successful outcome is mandatory until countries adopt the recent injectable-free WHO guideline and under specific conditions." | ( Nephrotoxicity and ototoxic symptoms of injectable second-line anti-tubercular drugs among patients treated for MDR-TB in Ethiopia: a retrospective cohort study. Admasu, A; Berha, AB; Negash, Z; Sheth, AN; Shibeshi, W; Yimer, G, 2019) | 0.51 |
| " Therefore, a reproducible and safe model for hearing-impaired animals is essential." | ( The ototoxic effect of locally applied kanamycin and furosemide in guinea pigs. Bako, P; Gerlinger, I; Löwenheim, H; Müller, M; Wolpert, S, 2022) | 0.99 |
Amikacin has a relation of half-life to rate of clearance of serum creatinine (Cer) of t1/2 = 3 X Cer. This is the same relation as found for kanamycin and gentamicin.
| Excerpt | Reference | Relevance |
|---|---|---|
| " Analysis of the tricompartmental model adopted for the pharmacokinetic study showed that kanendomycin half-life is similar and perhaps superior to that of gentamycin." | ( [Pharmacokinetics of a new aminoglycoside: kanendomycin]. Bosio, G; Bramato, C; Di Nola, F; Eandi, M; Sachelariu, N; Salassa, B; Soranzo, ML, 1979) | 0.26 |
| " Peripheral distribution of the drug is extremely rapid, and beta-phase concentrations decay with a half-life averaging about 2 hours, while inter-compartmental equilibrium is achieved in a little over 30 minutes." | ( Pharmacokinetics of intravenous amikacin after rapid and slow infusion with special reference to hemodialysis. Dugal, R; Pechere, JC; Pechere, MM, 1979) | 0.26 |
| " The biological half-life of DKB was prolonged in pretreatment with ABPC and that of ABPC was shortened in pretreatment with DKB." | ( [Fundamental studies of combination of antibiotics, especially on pharmacokinetics. III. Combination of ampicillin and dibekacin (author's transl)]. Aratani, H; Nakatsuka, M, 1979) | 0.26 |
| " Our study reports the changes in plasma concentration of kanamycin during an exchange transfusion and a pharmacokinetic analysis of the effect of the exchange on drug elimination." | ( Pharmacokinetic considerations in exchange transfusion in neonates. Kay, JL; Leff, RD; Smith, RB; Yakatan, GJ, 1978) | 0.26 |
| " The mean half-life was 114 +/- 16." | ( Pharmacokinetic and clinical studies with amikacin, a new aminoglycoside antibiotic. Grunert, K; Koeppe, P; Langmaack, H; Lode, H, 1976) | 0.26 |
| " The mean elimination half-life before the dialysis was 86." | ( Pharmacokinetics of amikacin during hemodialysis and peritoneal dialysis. Colding, H; Jensen, H; Kampmann, JP; Regeur, L, 1977) | 0.26 |
| " A prolonged serum half-life was associated with the related variables of birth at an early gestational age, low birth weight, and hypoxemia." | ( Effects of gestational age, birth weight, and hypoxemia on pharmacokinetics of amikacin in serum of infants. Mirhij, NJ; Myers, MG; Roberts, RJ, 1977) | 0.26 |
| " The serum levels of this drug were in proportion to dosage, and the pharmacokinetic parameters were almost the same through the three dosage levels." | ( Pharmacokinetics of dibekacin after intramuscular administration in man. Chow, SY; Komiya, I; Nakadori, S; Umemura, K, 1977) | 0.26 |
| " Determination of the rate of plasma clearance, half-life, and volume of distribution of amikacin in 10 patients with normal renal function, four patients undergoing dialysis, and five patients with end-stage renal diseases have shown a relation of half-life (t1/2 in hr) to rate of clearance of serum creatinine (Cer) of t1/2 = 3 X Cer, the same relation as found for kanamycin and gentamicin." | ( Pharmacokinetics of amikacin in patients with normal or impaired renal function: radioenzymatic acetylation assay. Blair, AD; Christopher, TG; Cutler, RE; Forrey, AW; O'Neill, MA; Plantier, J, 1976) | 0.42 |
| " There was a significant linear relation between the elimination rate constant of amikacin and the rate of creatinine clearance; there was a significant nonlinear relation between the half-life of amikacin and the serum creatinine concentration." | ( Pharmacokinetics of amikacin in patients with impaired renal function. Gavan, TL; Hall, PM; McHenry, MC; Vidt, DG; Wagner, JG, 1976) | 0.26 |
| " Additional pharmacokinetic studies indicated that the half-life of amikacin may be increased five- to 10-fold in patients with renal insufficiency." | ( Pharmacokinetics of amikacin for treatment of urinary tract infections in patients with reduced renal function. Demers, HG; Höffler, D; Koeppe, P, 1976) | 0.26 |
| "Comparative studies on some selected pharmacokinetic parameters for kanamycin in sheep, goats, rabbits, chickens and pigeons, and for apramycin in sheep, rabbits, chickens and pigeons were carried out after intravenous administration of the two drugs at a dose of 10 mg/kg." | ( Interspecies differences in the pharmacokinetics of kanamycin and apramycin. Lashev, LD; Marinkov, TN; Pashov, DA, 1992) | 0.53 |
| " Pharmacokinetic analysis was made in accordance with the two-compartment open model, and 24-hour endogenous creatinine clearance (Ccr) was used as the renal function index." | ( [Pharmacokinetics of arbekacin in healthy volunteers and patients with renal insufficiency]. Kishi, M; Kumon, H; Mizuno, A; Nasu, Y; Ohmori, H; Tsugawa, M, 1989) | 0.28 |
| "In vitro studies of elimination of arbekacin (HBK), a new aminoglycoside antibiotic, from blood by means of hemodialysis or adsorption with charcoal, and pharmacokinetic studies in patients with renal dysfunction were examined." | ( [Clinical study of aminoglycosides on renal dysfunction--pharmacokinetics of arbekacin and its elimination effects by hemodialysis and adsorption with charcoal]. Arakawa, S; Fujii, A; Hamada, K; Hara, S; Kamidono, S; Maeda, H; Miyazaki, S, 1989) | 0.28 |
| " The pharmacokinetic parameters of the antibiotics given separately were not altered by concurrent administration." | ( Effect of induced synovial inflammation on pharmacokinetics and synovial concentration of sodium ampicillin and kanamycin sulfate after systemic administration in ponies. Firth, EC; Klein, WR; Nouws, JF; Wensing, T, 1988) | 0.27 |
| " Elimination serum half-life increased in relation to the degree of renal impairment, from 2 h in normal subjects to 32 h in patients with creatinine clearance below 10 ml/min." | ( [Pharmacokinetics of habekacin in patients with chronic renal insufficiency]. Bernadet, P; Fillastre, JP; Humbert, G; Josse, S; Leroy, A; Moulin, B, 1987) | 0.27 |
| " The elimination half-life in serum increased in relation to the degree of renal impairment, from 2 h in normal subjects to 32 h in patients with creatinine clearances of less than 10 ml/min." | ( Pharmacokinetics of habekacin in patients with renal insufficiency. Bernadet, P; Fillastre, JP; Humbert, G; Josse, S; Leroy, A; Moulin, B, 1987) | 0.27 |
| " Comparison of pharmacokinetic parameters (i." | ( Pharmacokinetics of dibekacin in children with cystic fibrosis. Courcol, RJ; Delnatte, J; Loeuille, GA; Martin, GR, 1985) | 0.27 |
| " Amikacin had a short half-life (approx 1 hour) that was independent of the dosage." | ( Clinical pharmacokinetics of amikacin in dogs. Baggot, JD; Chatfield, RC; Ling, GV, 1985) | 0.27 |
| " The pharmacokinetic data were used to make dosage regimen recommendations for treatment of hemodialysis patients with these antibiotics." | ( Pharmacokinetics of gentamicin and kanamycin during hemodialysis. Danish, M; Jusko, WJ; Schultz, R, 1974) | 0.25 |
| "Comparative studies in beagle dogs suggested that the pharmacokinetic profiles of BB-K8 and kanamycin are similar." | ( Comparative pharmacokinetics of BB-K8 and kanamycin in dogs and humans. Cabana, BE; Taggart, JG, 1973) | 0.47 |
| " The mean half-life and mean serum concentration at 1 h for each drug was determined." | ( Reproducibility study of the pharmacokinetics of amikacin, gentamicin and tobramycin; a three-way crossover study. Acar, J; Adam, D; Cadorniga, R; Dyas, A; Hallynck, T; Pijck, J; Soep, HH; Wenk, M; Wise, R, 1983) | 0.27 |
| "A study was made of the serum levels and of the pharmacokinetic parameters of dibekacin after administration by intravenous infusion at a dose of 2 mg/kg of the drug to rabbits using different infusion times." | ( Effect of infusion time on the pharmacokinetics of dibekacin in rabbits. Dominguez-Gil, A; Lanao, JM; Navarro, AS, 1984) | 0.27 |
| "The capabilities of two pharmacokinetic amikacin dosing methods were evaluated and compared with the standard amikacin dosage recommended by the manufacturer." | ( Comparison of standard versus pharmacokinetically adjusted amikacin dosing in granulocytopenic cancer patients. Britten, J; Caplan, E; deJongh, CA; Finley, RS; Fortner, CL; Newman, KA; Schimpff, SC; Wade, JC; Wiernik, PH, 1982) | 0.26 |
| " No significant differences in clearance, volume of distribution or half-life were found due to age within a single drug group (amikacin, gentamicin, or tobramycin) or among the 3 drug groups." | ( Influence of age on amikacin pharmacokinetics in patients without renal disease. Comparison with gentamicin and tobramycin. Bauer, LA; Blouin, RA, 1983) | 0.27 |
| " After the initial intraventricular instillation of 5 mg of amikacin via a Rickham reservoir, a 10-fold variation in the cerebrospinal fluid (CSF) concentration and a fivefold variation in half-life of the drug were noted." | ( The pharmacokinetics and efficacy of an aminoglycoside administered into the cerebral ventricles in neonates: implications for further evaluation of this route of therapy in meningitis. Bowman, CM; Kaiser, AB; McGee, ZA; McKee, KT; Trujillo, H; Wright, PF, 1981) | 0.26 |
| "Serum amikacin concentrations were compared in infected renal transplant recipients that were compared in infected renal transplant recipients that were dosed using a creatinine-based nomogram (group I) or an individual computer-assisted pharmacokinetic dosing method (group II)." | ( Aminoglycoside dosing in renal transplant patients. Comparison of nomogram and individualized pharmacokinetic methods in patients with shifting renal function. Canafax, DM; Peterson, PK; Simmons, RL; Tofte, RW, 1982) | 0.26 |
| "The pharmacokinetic behavior of dibekacin was studied in 8 elderly subjects." | ( [Pharmacokinetic studies on intravenous drip infusion of dibekacin in elderly subjects without apparent renal failure (author's transl)]. Okada, K; Sawae, Y; Umemura, K, 1982) | 0.26 |
| "The principal pharmacokinetic parameters of dibekacin were studied in five adult subjects with normal renal function after IM and IV injection of a single dose of 1 mg/kg." | ( [Pharmacokinetics of dibekacin in subjects with normal renal function]. Borsa, F; Humbert, G; Leroy, A; Thauvin, C, 1982) | 0.26 |
| " Renal insufficiency caused a very marked prolongation in the serum half-life of elimination." | ( [Pharmacokinetics of dibekacin in patients with chronic renal impairment]. Fillastre, JP; Godin, M; Leroy, A; Viotte, G, 1982) | 0.26 |
| " The kidneys accumulated high amounts of dibekacin, and eliminated it with a half-life of about 7 days." | ( [Animal experiments on the nephrotoxicity, pharmacokinetics and therapeutic efficacy of dibekacin]. Bopp, S; Marre, R; Sack, K; Schulz, E, 1981) | 0.26 |
| " The route of administration did not significantly modify the pharmacokinetic parameters of amikacin." | ( Influence of the route of administration on the pharmacokinetics of amikacin. Corbacho, L; Dominguez-Gil, A; Lanao, JM; Tabernero, JM, 1981) | 0.26 |
| " These data were fitted to a two-compartment pharmacokinetic model." | ( Amikacin and gentamicin accumulation pharmacokinetics and nephrotoxicity in critically ill patients. Cerra, FB; French, MA; Plaut, ME; Schentag, JJ, 1981) | 0.26 |
| " 2) The biological half-life of dibekacin in mice was 24--45 min." | ( Acute toxicity and pharmacokinetics of dibekacin mice. Fujita, M; Kikai, S; Komiya, I; Murata, S; Tomono, N; Umemura, K, 1981) | 0.26 |
| " 1) In both rabbits and dogs, the pharmacokinetic constants for the intravenous constant infusion and intramuscular injection were similar to each other, and the serum levels after the intravenous constant infusion for 1 hr were similar to those after the intramuscular injection except the peak time." | ( Pharmacokinetics of dibekacin in rabbits and dogs. Fujita, M; Kikai, S; Komiya, I; Murata, S; Tomono, N; Umemura, K, 1981) | 0.26 |
| "The experimental investigation of pharmacokinetic properties of kanamycin and cephazolin has shown the antibiotic to penetrate well into the blood, lymph, abdominal exudate." | ( [Kanamycin sulfate and sodium cephazolin pharmacokinetics in experimental strangulation obstruction of the small intestine]. Eriukhin, IA; Poliak, MS; Rukhliada, NV, 1981) | 0.5 |
| " The pharmacokinetic behaviour of the three aminoglycosides was similar, in that a rapid distribution phase was followed by a relatively short half-life." | ( The pharmacokinetics of some aminoglycoside antibiotics in the horse. Baggot, JD; Love, DN; Raus, J; Rose, RJ, 1981) | 0.26 |
| " From the pharmacokinetic study of Amikacin in these patients, it may be deduced that the ascitic liquid forms part of the central compartment for the effects of distribution, though not for the effects of elimination." | ( The influence of ascites on the pharmacokinetics of amikacin. Diez, JL; Dominguez-Gil, A; Lanao, JM; Macias, JG; Nieto, MJ, 1980) | 0.26 |
| " The pharmacokinetic test results and the efficacy with severe infections showed dibekacin to be equivalent to the new aminoglycoside antibiotics gentamycin, sisomicin and tobramycin." | ( [Therapy of surgical infections with dibekacin. Pharmacokinetic, clinical and bacteriological results]. Primavesi, CA; Sievers, U; von Kobyletzki, D, 1980) | 0.26 |
| "5-fold increase in elimination half-life in the 12- versus 25-day-old rat." | ( Pharmacokinetics of kanamycin in the developing rat. Brown, RD; Henley, CM; Ou, CN; Weatherly, RA, 1996) | 0.29 |
| " These provided new pharmacokinetic data on high-dose levofloxacin, cycloserine and prothionamide given once daily, and could be useful in guiding the scheduling of drugs." | ( Serum pharmacokinetics of antimycobacterial drugs in patients with multidrug-resistant tuberculosis during therapy. Chan, CY; Chau, CH; Cheng, AF; Cheung, SW; Leung, CK; Wong, CF; Yew, WW, 1999) | 0.3 |
| " pharmacokinetic data on 670 drugs representing, to our knowledge, the largest publicly available set of human clinical pharmacokinetic data." | ( Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Lombardo, F; Obach, RS; Waters, NJ, 2008) | 0.35 |
| " To evaluate the pharmacokinetic (PK) characteristics of clinically relevant, multidrug treatment regimens and to improve the feasibility of TDM, we conducted an open-label, multiple-dosing study with 16 healthy subjects who were divided into two groups." | ( Pharmacokinetics of Second-Line Antituberculosis Drugs after Multiple Administrations in Healthy Volunteers. Chung, JY; Jang, IJ; Jang, K; Lee, JH; Moon, SJ; Oh, J; Park, JS; Park, SI; Song, J; Yoon, J; Yu, KS, 2015) | 0.42 |
| Excerpt | Reference | Relevance |
|---|---|---|
| " Tobramycin was the most effective aminoglycoside when used in combination with beta-lactam antibiotics." | ( In vitro activity of cefamandole, cefoxitin, cefuroxime, and carbenicillin, alone and in combination with aminoglycosides against Serratia marcescens. Bartlett, M; Crane, JK; Griffin, PS; Miller, MA; Yousuf, M, 1979) | 0.26 |
| "Continuous infusions of gentamicin, amikacin or sisomicin combined with carbenicillin were compared in a randomized study in the treatment of 572 febrile episodes in 281 patients with cancer." | ( A randomized comparative trial of three aminoglycosides--comparison of continuous infusions of gentamicin, amikacin and sisomicin combined with carbenicillin in the treatment of infections in neutropenic patients with malignancies. Bodey, GP; Keating, MJ; Rodriguez, V; Valdivieso, M, 1979) | 0.26 |
| "Therapeutic efficacy of kanamycin (KM) and clofazimine (CFZ) combined with N2-[(N-acetyl-muramyl)-L-alanyl-D-isoglutaminyl]-N6-stearoyl-L-ly sine, MDP-Lys (L18), against Mycobacterium intracellulare infection induced in mice was studied, based on suppression of incidence of gross lung lesions and bacterial growth at the sites of infection (lungs and spleen), and the following results were obtained." | ( [Therapeutic efficacy of kanamycin and clofazimine combined with muramyl dipeptide against Mycobacterium intracellulare infection induced in mice]. Saito, H; Sato, K; Tomioka, H, 1991) | 0.58 |
| "One hundred febrile episodes in neutropenic (PMN less than 500/mm3) patients were treated with Timentin alone or in combination with amikacin." | ( A prospective randomized study comparing the efficacy of Timentin alone or in combination with amikacin in the treatment of febrile neutropenic patients. Bru, JP; Hollard, D; Leautet, JB; Legrand, C; Michallet, M; Micoud, M; Sotto, JJ; Stahl, JP; Swierz, P, 1986) | 0.27 |
| "The in vitro activity of ceftriaxone alone and in combination with gentamicin, tobramycin, and amikacin against 50 Pseudomonas aeruginosa strains was studied by the broth dilution method and the time-kill curve method." | ( In vitro activity of ceftriaxone alone and in combination with gentamicin, tobramycin, and amikacin against Pseudomonas aeruginosa. Watanakunakorn, C, 1983) | 0.27 |
| "The in vitro bactericidal interactions of three new extended-spectrum cephalosporins (ceftriaxone, ceftizoxime, or ceftazidime) in combination with gentamicin or amikacin were compared against 40 recent nosocomial bloodstream Enterobacteriaceae isolates by the timed-kill curve technique." | ( Enhanced in vitro bactericidal activity of amikacin or gentamicin combined with three new extended-spectrum cephalosporins against cephalothin-resistant members of the family Enterobacteriaceae. Bayer, AS; Eisenstadt, R; Morrison, JO, 1984) | 0.27 |
| "The in vitro activities of imipenem (formerly imipemide, N-formimidoyl thienamycin, or MK0787) and amikacin in combination with cefotaxime, trimethoprim-sulfamethoxazole, and each other were tested against 26 Nocardia asteroides strains." | ( Synergism of imipenem and amikacin in combination with other antibiotics against Nocardia asteroides. Aulicino, TM; Gombert, ME, 1983) | 0.27 |
| "Serum bactericidal activity (SBA) was studied in vitro after intravenous administration of cefoperazone alone or in combination with mezlocillin or amikacin to human volunteers." | ( Comparative study of the serum bactericidal activity of cefoperazone alone and in combination with amikacin or mezlocillin against gram-negative bacilli and Staphylococcus aureus. Klastersky, J; Lagast, H; Standiford, H; Viollier, A, ) | 0.13 |
| "The MIC and MBC activity of mezlocillin alone and in combination with two concentrations of ceftizoxime, moxalactam, and amikacin and a single concentration of cefoxitin was studied in a broth microdilution partial checkerboard against 472 strains of aerobic gram-negative and gram-positive bacteria." | ( In vitro activities of ureidopenicillins alone and in combination with amikacin and three cephalosporin antibiotics. Gerding, DN; Moody, JA; Peterson, LR, 1984) | 0.27 |
| "The in vitro synergistic activity of aztreonam in combination with piperacillin, moxalactam, cefotaxime, cefoperazone, and amikacin was examined against multiply resistant isolates of the family Enterobacteriaceae and Pseudomonas aeruginosa." | ( In vitro activity of aztreonam in combination with newer beta-lactams and amikacin against multiply resistant gram-negative bacilli. Buesing, MA; Jorgensen, JH, 1984) | 0.27 |
| " Noise present in recreational or occupational environment may also be potentially damaging to the auditory system when combined with some ototoxic therapeutic agents." | ( Ototoxicity and noise-drug interaction. Bhattacharyya, TK; Dayal, VS, 1984) | 0.27 |
| "The in vivo activities of KRM-1648 alone or in combination with both ethambutol (EB) and kanamycin (KM) or clarithromycin (CAM) were tested against Mycobacterium intracellulare infections in beige mice." | ( Activity of KRM-1648 alone or in combination with both ethambutol and kanamycin or clarithromycin against Mycobacterium intracellulare infections in beige mice. Amitani, R; Kuze, F; Murayama, T; Suzuki, K; Tanaka, E; Yamamoto, T, 1996) | 0.29 |
| " For the continuous recording of glutamate, the microdialysis technique combined with an enzyme-linked fluorometric assay was used." | ( A role of glutamate in drug-induced ototoxicity: in vivo microdialysis study combined with on-line enzyme fluorometric detection of glutamate in the guinea pig cochlea. Haruta, A; Kato, E; Komune, S; Matsuda, K; Tono, T; Yamasaki, M, 2000) | 0.31 |
| "To study the efficacy and safety of sparfloxacin, in combination with kanamycin (for the initial 3-4 months) and ethionamide, in multidrug-resistant (MDR) pulmonary tuberculosis patients." | ( Efficacy and safety of sparfloxacin in combination with kanamycin and ethionamide in multidrug-resistant pulmonary tuberculosis patients: preliminary results. Arora, VK; Gupta, R; Gupta, S; Singla, R, 2001) | 0.56 |
Thirty children over the age of one month were treated with amikacin (BBK8), a new aminoglycoside derived from kanamycin A. The kinetic parameters governing the distribution and elimination of BB-K8 and Kanamycin after an im dose were similar to those obtained for iv dosing and indicate desirable dose-independent kinetics.
| Excerpt | Relevance | Reference |
|---|---|---|
| "0002 dyne cm-2) and were subsequently injected subcutaneously with kanamycin (400 mg kg-1 day-1) for 28 days; during this time and for five weeks after dosage was stopped, the nature and extent of the resultant hearing deficits were studied." | ( The quantification of kanamycin ototoxicity in the rat using conditioned tone discrimination. D'Arcy, PF; Harpur, ES, 1975) | 0.25 |
| " In the second group, the dosage of each antibiotic necessary to induce apnea is sought." | ( [Neuromuscular inhibition of new aminoglycoside antibiotics]. Baltar, I; Esplugues, J; Marti, JL; Orts, A, 1979) | 0.26 |
| " But this effect is small and does not justify a change in the usual dosage of rifampicin." | ( [The use of mycobacteria in the estimation of the concentration of antibiotics, antimycotics and antituberculotics (author's transl)]. Iwainsky, H; Reutgen, H; Sesser, I, 1978) | 0.26 |
| " Under the experimental conditions outlined, it was found that after a dosage of 150 mg/kg/day of kanamycin given to a physiologic end point, normally subtraumatic noise caused consistent increas in hearing loss." | ( Audiometric and histologic correlates of the interaction between kanamycin and subtraumatic levels of noise in the chinchilla. Bone, RC; Ryan, AF, ) | 0.37 |
| " This variation in penetration reflected individual differences in each dosage group and the increase in percent penetration that was observed during therapy." | ( Comparison of four aminoglycoside antibiotics in the therapy of experimental E. coli meningitis. Mandaleris, CD; Sande, MA; Strausbaugh, LJ, 1977) | 0.26 |
| " The recommended 12-hourly dosage regimen has also proved useful in medium- to long-term management of refractory pulmonary infections." | ( Clinical experience with amikacin, a new aminoglycoside antibiotic. De Kock, MA; Theron, FP, 1977) | 0.26 |
| " Our data indicate that low dosage amikacin sulfate is satisfactory in the treatment of complicated urinary tract infections." | ( Treatment of complicated urinary tract infections with amikacin: comparison of low and high dosage. Harrison, LH, 1977) | 0.26 |
| " Intramuscular dosage schedules were calculated, based on the sensitivity of the different bacterial strains and the duration of effective serum drug concentrations." | ( Comparative clinical pharmacology of amikacin and kanamycin in dairy calves. Ziv, G, 1977) | 0.26 |
| " Ototoxicity, highly correlated with a duration of greater than 19 days and a total dosage of greater than 25 g of amikacin sulfate, occurred in four patients (5." | ( Empiric therapy for infections in granulocytopenic cancer patients: continuous infusion of amikacin plus cephalothin. Curtis, JE; Feld, R; Hasselback, R; Messner, HA; Tuffnell, PG, 1979) | 0.26 |
| " Separate in vitro experiments with gentamicin, however, revealed an inverse dose-response relationship with chemotactic suppression." | ( Abnormal neutrophil chemotaxis and random migration induced by aminoglycoside antibiotics. Chang, CT; Evans, HE; Glass, L; Khan, AJ; Khan, P; Nair, SR, 1979) | 0.26 |
| " The dosage range of ethacrynic acid during which the interaction occurs is very narrow, while the dose range of kanamycin is very large." | ( Quantitative relationships of the ototoxic interaction of kanamycin and ethacrynic acid. Brown, RT; Brummett, RE; Himes, DL, 1979) | 0.5 |
| " A dosage regimen as a function of the pharmacokinetic parameters is established for patients with terminal renal impairment which guarantees safe and efficient concentrations of the antibiotic." | ( Pharmacokinetics of amikacin (BB-K8) in patients undergoing hemodialysis. Dominguez-Gil, A; Lanao, JM; Sanchez Tomero, JA; Tabernero, JM, 1979) | 0.26 |
| " Pharmacists, in consultation with the infectious diseases service, made recommendations for alternative antibiotic therapy or dosage regimens, provided drug education to prescribing physicians and nurses, and aided in monitoring efficacy and toxicity of therapy." | ( Aminoglycoside use monitored by clinical pharmaceutical services. Barriere, SL; Conte, JE, 1979) | 0.26 |
| " Dosing intervals during 1 or 2 and 3 or 4 days of therapy were studied with serum samples collected before and at the end of the infusion and serially to the end of the dosing interval." | ( Multiple-dose amikacin kinetics in pediatric oncology patients. Cleary, T; Frankel, LS; Kohl, S; Kramer, WG; Pickering, LK, 1979) | 0.26 |
| " The influence of dosage and renal function on serum levels and their relevance to ototoxicity are discussed." | ( Suggestions for monitoring patients during treatment with aminoglycoside antibiotics. Lerner, SA; Matz, GJ, ) | 0.13 |
| " The alternative methods which are not based on the assumption, are given under suitable dose-response curves by introducing a risk level." | ( Estimation of safe doses: critical review of the hockey stick regression method. Yamamoto, E; Yanagimoto, T, 1979) | 0.26 |
| " A linear relation between concentrations in the perilymph and dosage of gentamicin was ascertained." | ( [Pharmacokinetical, histological, and histochemical investigation on the ototoxicity of gentamicin, tobramycin, and amikacin (author's transl)]. Federspil, P; Schätzle, W; Tiesler, E, 1977) | 0.26 |
| "5; 5; 10; 20; 100 and 500 mg/kg/day; dosage interval: 12 h) over a period of 5 days." | ( [Amikacin and kanamycin. Comparative experimental studies on nephrotoxicity]. Sack, K; Züllich, B, 1978) | 0.26 |
| " The low dose-response curves obtained presenting no significant deviation from parallelism are highly suggestive of a competitive type of antagonism between those substances." | ( Competitive antagonism between calcium and antibiotics at the neuromuscular junction. Corrado, AP; Marseillan, RF; Prado, WA, 1978) | 0.26 |
| " Questions may be raised whether dosage regimen alterations are necessary to replace drug lost as a result of the exchange procedure." | ( Pharmacokinetic considerations in exchange transfusion in neonates. Kay, JL; Leff, RD; Smith, RB; Yakatan, GJ, 1978) | 0.26 |
| "Netilmicin, gentamicin, tobramycin, amikacin, kanamycin, streptomycin, and sisomicin were given daily for 15 days to groups of rats at three dosage levels corresponding to 10, 15, or 25 times the dose recommended for humans on a weight basis." | ( Comparative nephrotoxicity of aminoglycoside antibiotics in rats. Bloch, R; Costello, R; Luft, FC; Maxwell, DR; Sloan, RS; Yum, MN, 1978) | 0.26 |
| " This more rapid elimination necessitated a shorter dosing interval (every 6 hours), resulting in an increased daily dose (30 mg/kg/day)." | ( The necessity of increased doses of amikacin in burn patients. Sawchuk, RJ; Strate, RG; Zaske, DE, 1978) | 0.26 |
| " The pharmacokinetic parameters in the computer program were used to generate a new aminoglycoside dosing chart." | ( Amikacin serum concentrations: prediction of levels and dosage guidelines. Hull, JH; Sarubbi, FA, 1978) | 0.26 |
| " The dosage was 125." | ( [Amikacin in urinary tract infections with so-called problem pathogens]. Hofstetter, A; Staehler, G, 1976) | 0.26 |
| " Gentamicin, sisomicin and amikacin are useful against Serratia infections; but in each case, a higher dosage is needed." | ( Comparative evaluation of five aminoglycosides for treatment. Köhler, M; Naumann, P; Reintjens, E; Rosin, H, 1976) | 0.26 |
| "The applicability of a computerized dosage regimen determination based on a recently developed method for drugs following the minimum inhibitory concentration pattern (bacteriostatic drugs) has been tested for kanamycin injected intramuscularly in 8 patients with varying degrees of renal impairment." | ( Computer-calculated kanamycin dosage regimen and monitoring. Banarer, M; Lau-Chang, EF; Ritschel, WA, 1977) | 0.26 |
| " The pharmacokinetic data were used to make dosage regimen recommendations for the treatment of patients undergoing intermittent hemodialysis or peritoneal dialysis." | ( Pharmacokinetics of amikacin during hemodialysis and peritoneal dialysis. Colding, H; Jensen, H; Kampmann, JP; Regeur, L, 1977) | 0.26 |
| " Depending upon the dosage of the administered drug, Amikacin (150 mg per kg body weight daily, corresponding to 10 times an average recommended human dose) caused pronounced outer hair cell damage even 1 day after the treatment was stopped." | ( Comparative surface studies of ototoxic effects of various aminoglycoside antibiotics on the organ of Corti in the guinea pig. A scanning electron microscopic study. Theopold, HM, ) | 0.13 |
| "Pharmacokinetic behavior of dibekacin after intramuscular administration was studied in nine healthy volunteers by cross over administrations of three dosage levels (1 mg(pot." | ( Pharmacokinetics of dibekacin after intramuscular administration in man. Chow, SY; Komiya, I; Nakadori, S; Umemura, K, 1977) | 0.26 |
| "Amikacin was used in 77 treatment courses at a dosage of >/=7." | ( Ototoxicity of amikacin. Black, RE; Hewitt, WL; Lau, WK; Weinstein, RJ; Young, LS, 1976) | 0.26 |
| " A linear relation between concentrations in the perilymph and the dosage of gentamicin was ascertained." | ( Pharmacokinetics and ototoxicity of gentamicin, tobramycin, and amikacin. Federspil, P; Schätzle, W; Tiesler, E, 1976) | 0.26 |
| " Protection was dosage related, and potentiated with increasing doses, but only when the two drugs were given simultaneously." | ( Protective effect of D-glucaro-delta-lactam against amino-glycoside-induced nephrotoxicity in rats. Inouye, S; Koeda, T; Niida, T; Nizato, T; Tsuruoka, T, 1976) | 0.26 |
| " The calculated half-life values may be used for development of appropriate dosage schedules for patients with various degrees of renal function." | ( Pharmacokinetics of amikacin in patients with renal insufficiency: relation of half-life and creatinine clearance. Baert, L; Boelaert, J; Daneels, R; Hallynck, T; Pijck, J; Soep, H, 1976) | 0.26 |
| " Knowledge of these relations may aid in adjustment of the dosage of amikacin in patients with impaired renal function, especially when such information is used in conjunction with serum assays of amikacin." | ( Pharmacokinetics of amikacin in patients with impaired renal function. Gavan, TL; Hall, PM; McHenry, MC; Vidt, DG; Wagner, JG, 1976) | 0.26 |
| " A tentative dosage schedule was prepared for patients with various degrees of impaired renal function on the basis of average half-life values." | ( Pharmacokinetics of amikacin for treatment of urinary tract infections in patients with reduced renal function. Demers, HG; Höffler, D; Koeppe, P, 1976) | 0.26 |
| "Thirty children over the age of one month were treated with amikacin (BBK8), a new aminoglycoside derived from kanamycin A, with three intramuscular dosage schedules." | ( Amikacin (BBK8) in infections due to gram-negative organisms in children over the age of one month. Agudelo, NH; de Vidal, EL; Ramirez, JI; Trujillo, H; Uribe, A, 1976) | 0.47 |
| " Calculated distribution volumes, plasma clearances, and serum half-life values were used in formulating a revised kanamycin in dosage and frequency of administration schedule." | ( Reappraisal of kanamycin usage in neonates. Howard, JB; McCracken, GH, 1975) | 0.25 |
| "Indications, side effects, dosage and several pharmacokinetic properties of gentamicin, tobramycin, sisomicin, kanamycin, amikacin, and streptomycin are delt with in the first part." | ( [Aminoglycoside antibiotics from clinical viewpoint]. Lüthy, R, 1975) | 0.25 |
| " Because it has a low therapeutic index, monitoring of serum levels may help to insure adequacy of dosage and avoid toxicity." | ( Radioimmunoassay, acetylating radio-enzymatic assay, and microbioassay of gentamicin: a comparative study. Hewitt, WL; Stevens, P; Young, LS, 1975) | 0.25 |
| " In a second series of 27 orthotopic liver transplantations in tissue-typed littermate dogs and littermate pigs the standard surgical technique and aftercare were changed with regard to four factors: an end-to-end common bile duct anastomosis was made instead of a gallbladder to duodenum anastomosis; the continuous postoperative bacteriostatic antibiotic therapy was changed to a single 2-day course of bactericidal antibiotics; preoperative selective bowel decontamination combined with postoperative protective isolation was introduced; the dosage of azathioprine used for immunosuppression was reduced." | ( Orthotopic liver transplantation: an experimental study on the prevention of infections with Gram-negative organisms. Hendriks, WD; Jerusalem, C; Krom, RA; Popescu, DT; Schalm, SW; Terpstra, JL; Van Der Waay, D, 1975) | 0.25 |
| "Aerosols of kanamycin resulted in greater survival of mice challenged with respiratory Klebsiella pneumoniae than the same dosage given intramuscularly." | ( Treatment of respiratory Klebsiella pneumoniae infection in mice with aerosols of kanamycin. Berendt, RF; Long, GG; Walker, JS, 1975) | 0.25 |
| " The dosage range for furosemide was 50 mg/kg for a just-detectable effect to 100 mg/kg for a very severe effect." | ( Cochlear damage resulting from kanamycin and furosemide. Brown, R; Brummett, RE; Himes, D; Traynor, J, ) | 0.42 |
| " Four groups of comparable weight Sprague-Dawley rats received a daily subcutaneous dosage of 225 mg/kg kanamycin sulfate with each receiving the antibiotic at a different time: 8 AM (8A), 2 PM (2P), 8 PM (8P), and 2 AM (2A)." | ( Circadian rhythm dependent kanamycin-induced hearing loss in rodents assessed by auditory brainstem responses. Fisch, JE; Yonovitz, A, 1991) | 0.28 |
| " The dosage schedule used involved two intraperitoneal administrations of SPLV-entrapped aminoglycosides at three-day intervals." | ( Treatment of Brucella canis and Brucella abortus in vitro and in vivo by stable plurilamellar vesicle-encapsulated aminoglycosides. Fountain, AG; Fountain, MW; Lenk, RP; Shen, A; Weiss, SJ, 1985) | 0.27 |
| " The degree of renal impairment depended on the dosage of LMWD." | ( [Experimental study of drug-induced acute renal failure. Recovery after renal impairment caused by the administration of low molecular weight dextran and kanamycin in water-deprived rats]. Ishikawa, E, 1988) | 0.27 |
| " In conclusion, if it could be necessary to use habekacin and to prefer this aminoglycoside to gentamicin from an antibacterial activity point of view it is necessary to keep in mind that this drug is potentially nephrotoxic and that the dosage had to be strictly respected." | ( [Habekacin: a new aminoglycoside. Study of nephrotoxicity in rats in comparison with gentamicin, netilmicin and amikacin]. Fillastre, JP; Morin, JP; Olier, B; Thomas, N, 1988) | 0.27 |
| " The vigor of the pinna reflex response on postnatal day (PND) 28 was correlated with (a) age at the time of injection, (b) dosage and (c) individual audiogenic seizure severity scores on PND 28 or PND 32." | ( The sensitive period and optimum dosage for induction of audiogenic seizure susceptibility by kanamycin in the Wistar rat. Pierson, MG; Swann, JW, 1988) | 0.27 |
| " It should be emphasized, however, that the standard dosage of aminoglycosides in patients with cystic fibrosis frequently results in serum concentrations that are lower than anticipated because of a relatively larger volume of drug distribution and a greater urinary excretion rate." | ( Aminoglycoside toxicity in infants and children. McCracken, GH, 1986) | 0.27 |
| "The bactericidal activity of the aminoglycoside antibiotics streptomycin and kanamycin for Mycobacterium leprae in mice was assessed, both alone and in combination with rifampin, utilizing various dosage schedules." | ( Further studies of the killing of M. leprae by aminoglycosides: reduced dosage and frequency of administration. Gelber, RH, 1987) | 0.27 |
| " Dosage of 50 mumol for kanamycin A sulfate and 5 mumol for spermine caused total damage of the outer hair cells in all ears." | ( Cochleotoxic effects of spermine and kanamycin. Wright, A; Yung, MW, ) | 0.44 |
| " Equivalent antibiotic dosing was based on the time rat serum antibiotic levels were above the minimal bactericidal concentration for the challenge organism." | ( Efficacy of single-agent therapy with azlocillin, ticarcillin, and amikacin and beta-lactam/amikacin combinations for treatment of Pseudomonas aeruginosa bacteremia in granulocytopenic rats. Johnson, DE; Thompson, B, 1986) | 0.27 |
| "The therapeutic efficacy, tolerance and pharmacokinetics of sisomicin, gentamicin and a new dosage form of kanamycin sulfate as an ampoule solution for intravenous injection were studied clinically." | ( [Present-day aminoglycosides in the treatment of suppurative-septic diseases]. Firson, AA; Kolker, II; Lobuseva, AN; Navashin, PS; Pozdniakova, VP, 1985) | 0.27 |
| "Six healthy pony foals, from 2 to 11 days of age, were given a single IM injection of amikacin sulfate (250 mg/ml) at a dosage rate of 7 mg/kg of body weight." | ( Pharmacokinetics of amikacin in pony foals after a single intramuscular injection. Beal, C; Brown, MP; Gronwall, RR; Martinez, DS, 1986) | 0.27 |
| " The dosage determination in the dialysis patients receiving these drugs is discussed." | ( Effect of peritoneal dialysis on serum concentrations of three drugs commonly used in pediatric patients. Chow-Tung, E; John, EG; Lau, AH; Vidyasagar, D, 1985) | 0.27 |
| " Drug concentrations in plasma were found to be threefold higher in anesthetized animals, whereas drug levels in perilymph were the same in both groups at similar dosing rates." | ( Effect of pentobarbital anesthesia on amikacin concentrations in plasma and perilymph and evaluation of multiple sampling in perilymph of guinea pigs. Beaubien, AR; Cauchy, MJ; Desjardins-Giasson, S, 1985) | 0.27 |
| "6 mg/kg twice daily and, for the more serious life-threatening infections, dosing three times a day." | ( Pharmacokinetics of amikacin in the horse following intravenous and intramuscular administration. Orsini, JA; Park, M; Rourke, JE; Soma, LR, 1985) | 0.27 |
| " For dogs with normal renal function, an amikacin dosage of 10 mg/kg (IM or subcutaneously) is recommended every 8 hours for treatment of systemic infections, and every 12 hours for treatment of urinary tract infections caused by susceptible bacteria." | ( Clinical pharmacokinetics of amikacin in dogs. Baggot, JD; Chatfield, RC; Ling, GV, 1985) | 0.27 |
| " Expressed as a percentage of the injected amount, the uptake decreased as the aminoglycoside dosage increased." | ( Nephrotoxicity of aminoglycosides in young and adult rats. Adejuyigbe, O; Provoost, AP; Wolff, ED, 1985) | 0.27 |
| " The pharmacokinetic data were used to make dosage regimen recommendations for treatment of hemodialysis patients with these antibiotics." | ( Pharmacokinetics of gentamicin and kanamycin during hemodialysis. Danish, M; Jusko, WJ; Schultz, R, 1974) | 0.25 |
| " The kinetic parameters governing the distribution and elimination of BB-K8 and kanamycin after an im dose were similar to those obtained for iv dosing and indicate desirable dose-independent kinetics." | ( Comparative pharmacokinetics of BB-K8 and kanamycin in dogs and humans. Cabana, BE; Taggart, JG, 1973) | 0.48 |
| " With the dosage given, gentamicin gave a low serum and a relatively high urine concentration." | ( Treatment of chronic urinary tract infections with gentamicin. Bucht, H; Kallings, LO; Lindberg, AA, 1967) | 0.25 |
| " Although HPO alone is primarily bacteriostatic, combined therapy with antibiotics and HPO may be useful against bacterial infections because the therapeutic effectiveness of a maximal dosage of antibiotic could be increased." | ( Enhancement of antibiotic activity against Staphylococcus aureus by exposure to hyperbaric oxygen. Bornside, GH, 1967) | 0.25 |
| " These measurements confirmed the dosage of 5 micrograms per kg repeated every 8 hours in patients with normal renal function." | ( [Serial measurement of serum levels of amikacin. Value in therapy]. Charrel, CT; François, G; Gouin, F; Granthil, C; Martin, C; Savin, B, 1981) | 0.26 |
| " So, because of the risk of ototoxicity, the dosage should be reduced to 10 mg per kg-1 per 24 h-1, with measurements of the serum peak level and the level just before the following injection." | ( [Kinetics of multiple-dose amikacin in the newborn infant]. Camboulives, J; Charrel, C; Olivesi, A; Unal, D, 1981) | 0.26 |
| " over a course of 5 days; dosage interval 12 h, dosage 2,5, 5, 10, 20, 100 and 500 mg/kg per day, respectively." | ( [Experimental study on renal tolerability of aminoglycosides butirosin and bekanamycin (author's transl)]. Beck, H; Eikenberg, P; Sack, K, 1980) | 0.26 |
| " The experience of earlier investigations demonstrated the need for quantitative measurements and individual patient dosing which has reduced the risk of toxicity many fold." | ( The key role of aminoglycosides in antibacterial therapy and prophylaxis. Jackson, GG, 1984) | 0.27 |
| "Six mares were given 5 IM injections (at 12-hour intervals between doses) of amikacin sulfate at a dosage of 7 mg/kg of body weight." | ( Amikacin sulfate in mares: pharmacokinetics and body fluid and endometrial concentrations after repeated intramuscular administration. Beal, C; Brown, MP; Curry, SH; Embertson, RM; Gronwall, RR; Mayhew, IG, 1984) | 0.27 |
| " Amikacin levels in plasma and perilymph were measured in guinea pigs after continuous intravenous infusion at four different dosing rates." | ( Correlation of amikacin concentrations in perilymph and plasma of continuously infused guinea pigs. Beaubien, AR; Desjardins-Giasson, S, 1984) | 0.27 |
| " These total daily doses were administered according to three different dosing schedules, either as a single injection given once a day, divided into two equal doses and given twice a day, or divided into four equal doses and administered four times a day." | ( Dissociation of maximum concentration of kanamycin in plasma and perilymph from ototoxic effect. Bendrick, TW; Brummett, RE; Davis, RR; Himes, DL, 1984) | 0.27 |
| " Although this colorimetric method is not expected to be stability-indicating, it is convenient and should be useful in content uniformity determinations for pharmaceutical dosage forms (e." | ( Colorimetric determination of gentamicin, kanamycin, tobramycin, and amikacin aminoglycosides with 2,4-dinitrofluorobenzene. Ryan, JA, 1984) | 0.27 |
| " The daily dosage of cefoperazone ranged from 2 to 4 gm in two equally divided doses, and the daily dosage of amikacin ranged from 900 to 1,000 mg in two equally divided doses." | ( Comparative study of cefoperazone and amikacin. Chang, ST; Chung, ES; Whang, CW, 1984) | 0.27 |
| "A spectrophotometric assay method for the quantitative determination of amikacin, kanamycin, neomycin, and tobramycin in pharmaceutical dosage forms has been developed." | ( Quantitation of amikacin, kanamycin, neomycin, and tobramycin in pharmaceutical dosage forms using the Hantzsch reaction. Gunter, JM; Gupta, VD; Stewart, KR, 1983) | 0.27 |
| " An intravenous drip infusion of AMK in adequate dosage would be beneficial to use against some infectious diseases of otorhinolaryngologic field." | ( [Clinical evaluation of ototoxicity associated with intravenous drip infusion of amikacin]. Hanamure, Y; Hashimoto, M; Iida, F; Kiyota, R; Kurono, Y; Maeyama, T; Ogawa, K; Ohhori, Y, 1983) | 0.27 |
| "To determine an adequate dosage of amikacin, a pharmacokinetic model was used based on lean body mass (LBM), age and serum creatinine." | ( Clinical application of amikacin dosage based upon lean body mass in patients with different renal function. Fieren, MW; Goessens, WH; Michel, MF; Wagenvoort, JH, 1984) | 0.27 |
| "The capabilities of two pharmacokinetic amikacin dosing methods were evaluated and compared with the standard amikacin dosage recommended by the manufacturer." | ( Comparison of standard versus pharmacokinetically adjusted amikacin dosing in granulocytopenic cancer patients. Britten, J; Caplan, E; deJongh, CA; Finley, RS; Fortner, CL; Newman, KA; Schimpff, SC; Wade, JC; Wiernik, PH, 1982) | 0.26 |
| " After having given their written informed consent, 50 patients were treated with a dosage of 150-225 mg dibekacin, administered in three single daily doses." | ( [Therapy of urinary tract infections with dibekacin]. Kuber, W; Loebenstein, T; Maier, U, 1983) | 0.27 |
| " Thus a 12-h dosage schedule was superior to a 24-h regimen." | ( Experimental respiratory tract infection with Klebsiella pneumoniae DT-S in mice: chemotherapy with kanamycin. Nishi, T; Tsuchiya, K, 1980) | 0.26 |
| "The efficacies of several dosage schedules, productive of plasma levels of cefotiam and cefazolin of short and long duration and starting at three levels of cefotiam and cefazolin of short and long duration and starting at three different times (3, 18, and 30h) after infection, were examined in experimental pneumonia caused by Klebsiella pneumoniae DT-S in mice." | ( Therapeutic effects of cefotiam and cefazolin on experimental pneumonia caused by Klebsiella pneumoniae DT-S in mice. Nishi, T; Tsuchiya, K, 1980) | 0.26 |
| "Serum amikacin concentrations were compared in infected renal transplant recipients that were compared in infected renal transplant recipients that were dosed using a creatinine-based nomogram (group I) or an individual computer-assisted pharmacokinetic dosing method (group II)." | ( Aminoglycoside dosing in renal transplant patients. Comparison of nomogram and individualized pharmacokinetic methods in patients with shifting renal function. Canafax, DM; Peterson, PK; Simmons, RL; Tofte, RW, 1982) | 0.26 |
| " In 5, Kanamycin was administered in ototoxic dosage until the thresholds deteriorated." | ( Selective destruction of the outer hair cells in the chinchilla. Browning, GG; Cortese, R; Northrop, R, 1982) | 0.26 |
| "576 serum levels at peak and before the next dosage (end level) were determined during clinical treatment conditions using radioimmunoassay in 131 patients treated with tobramycin or amikacin because of life-threatening infections." | ( [Control of serum levels of tobramycin and amikacin during clinical routine treatment conditions (author's transl)]. Daschner, F; Eiermann, T; Langmaack, H; Stark, GB, 1982) | 0.26 |
| " A dosage regimen for administration of the antibiotic is proposed for this kind of patient on the basis of desired peak and trough serum levels obtained throughout treatment." | ( Disposition kinetics of amikacin in patients with renal impairment after intramuscular administration. Dominguez-Gil, A; Lanao, JM; Molina, HD; Tabernero, JM, 1982) | 0.26 |
| " Comparatively, kanamycin has a major ototoxic effect when it is administrated at the same dosage during the same period of time." | ( [Experimental study of the intrauterine ototoxicity of dibekacin]. Marot, M; Uziel, A, 1982) | 0.26 |
| " After repetitive dosing a distinct tendency to accumulation (highest renal concentration: 330 microgram/g) could be detected." | ( [Animal experiments on the nephrotoxicity, pharmacokinetics and therapeutic efficacy of dibekacin]. Bopp, S; Marre, R; Sack, K; Schulz, E, 1981) | 0.26 |
| " There were no statistical differences between the gentamicin- and amikacin-treated patients in age, sex, weight, base-line creatinine clearance, concurrent cephalosporins or diuretics, treatment duration, site of infection, normalized (amikacin/gentamicin dosing ratio of 3:1) total dose, mortality, or tissue accumulation." | ( Amikacin and gentamicin accumulation pharmacokinetics and nephrotoxicity in critically ill patients. Cerra, FB; French, MA; Plaut, ME; Schentag, JJ, 1981) | 0.26 |
| " From thie equation, the dosage interval is modified to maintain the serum concentrations of the antibiotic within the therapeutic interval." | ( Pharmacokinetics of amikacin in children with normal and impaired renal function. Crespo, M; Dominguez-Gil, A; Dominguez-Gil, AA; Lanao, JM; Málaga, S; Santos, F, 1981) | 0.26 |
| " The same drug dosage administered between the age of 5-19, 15-19, or 20-24 postnatal days was found to be ineffective." | ( The sensitive period for induction of susceptibility to audiogenic seizures by kanamycin in mice. Aberdeen, GC; Chen, CS, 1981) | 0.26 |
| "Six healthy adult mares were given a single dose of kanamycin sulfate (200 mg/ml) IM at a dosage rate of 5 mg/kg of body weight." | ( Kanamycin sulfate in the horse: serum, synovial fluid, peritoneal fluid, and urine concentrations after single-dose intramuscular administration. Brown, MP; Farver, TB; Kelly, RH; Stover, SM, 1981) | 0.26 |
| " A dosage interval of 8 h would be appropriate for kanamycin compared with a 12-h interval for streptomycin." | ( The pharmacokinetics of some aminoglycoside antibiotics in the horse. Baggot, JD; Love, DN; Raus, J; Rose, RJ, 1981) | 0.26 |
| " In the last of the 10 patients included in the survey, the evolution of the plasma concentrations of the antibiotic were studied while the patient was undergoing a multiple dosage regimen with the aim of determining the accumulation of Amikacin in the ascitic fluid." | ( The influence of ascites on the pharmacokinetics of amikacin. Diez, JL; Dominguez-Gil, A; Lanao, JM; Macias, JG; Nieto, MJ, 1980) | 0.26 |
| " In this study the auditory brain stem response to "clicks" at two intensities and two repetition rates were recorded from guinea pigs that had been given one of two dosage levels of kanamycin or no drug." | ( The effects of ototoxicity on the auditory brain stem response and the scalp-recorded cochlear microphonic in guinea pigs. Jewett, DL; Schwent, VL; Williston, JS, 1980) | 0.26 |
| "The recommended neonatal dosage regime for amikacin of 15 mg/kg/day was found to be unsatisfactory in four neonates and a loading dose of 10 mg/kg did not improve levels in two further newborns with normal renal function." | ( Evaluation of amikacin dosage regimes in the low and very low birthweight newborn. Cookson, B; Leung, T; Tripp, J; Williams, JD, 1980) | 0.26 |
| " Furthermore, many of these assessments have used only one or two dose levels and have not described a dose-response comparison among antibiotics." | ( Comparative low-dose nephrotoxicities of gentamicin, tobramycin, and amikacin. Gordon, LL; Hottendorf, GH, 1980) | 0.26 |
| " Dibekacin and gentamicin show reproducibly higher renal cortical tissue concentrations than tobramycin in both the acute infusion studies and multiple dosing studies." | ( Dibekacin intrarenal distribution characteristics and renal cortical elution kinetics. Comparison with gentamicin and tobramycin. Bryant, HH; Carter, GG; Herbst, DV; Stout, RL; Walker, G; Whelton, A, ) | 0.13 |
| " From the calculated pharmacokinetic parameters, a dosage regimen for this kind of patient is proposed." | ( Disposition of Dibekacin in patients undergoing haemodialysis. Campillo, JA; Dominguez-Gil, A; Lanao, JM; Martin, A; Rubio, F, 1980) | 0.26 |
| " We also observed that repeating the dosing schedule following a 4 month survival period resulted in significantly less damage to the regenerated auditory epithelium." | ( Regenerated hair cells in the European starling: are they more resistant to kanamycin ototoxicity than original hair cells? Beecher, MD; Burt, JM; Cunningham, D; Marean, GC; Rubel, EW, 1995) | 0.29 |
| " Thresholds shifted again, but less than during the first dosing period." | ( Hair cell regeneration in the European starling (Sturnus vulgaris): recovery of pure-tone detection thresholds. Beecher, MD; Burt, JM; Marean, GC; Rubel, EW, 1993) | 0.29 |
| "The disposition kinetics and appropriate dosage regimen for kanamycin were investigated in buffalo calves following a single intravenous dose of 10 mg/kg body weight." | ( Disposition kinetics, urinary excretion and dosage regimen of kanamycin in buffalo calves following single intravenous administration. Chaudhary, RK; Rampal, S; Srivastava, AK, 1993) | 0.29 |
| " The dosage of beta-lactamase during the exponential growth phase has revealed that the strain BS3 produces a maximal amount of this enzyme." | ( [Thermophilic bacteria resistant to antibiotics in traditional public baths]. Filali, FR; Frere, JM; Zaid, A; Zekhnini, Z, 1997) | 0.3 |
| " They are isogenic apart from the ts mutations in the repA gene, and thus provide with useful tools for having appropriate controls in various experiments including bacterial gene-targeting, transposon mutagenesis, toxic gene expression, differential substitution on host functions, gene dosage analysis and so on." | ( A set of temperature sensitive-replication/-segregation and temperature resistant plasmid vectors with different copy numbers and in an isogenic background (chloramphenicol, kanamycin, lacZ, repA, par, polA). Hashimoto-Gotoh, T; Tsujimura, A; Wakabayashi, Y; Watanabe, Y; Yamaguchi, M; Yasojima, K, 2000) | 0.31 |
| "Six beagle dogs were treated with kanamycin subcutaneously or intravenously in a dosage of 5 mg/kg." | ( [Pharmacokinetics of kanamycin after subcutaneous and intravenous administration in dogs]. Calvo Wieland, A; Ehinger, AM; Kietzmann, M; Nolte, I, ) | 0.45 |
| " This study compared the incidences of toxicities associated with 2 recommended dosing regimens." | ( Aminoglycoside toxicity: daily versus thrice-weekly dosing for treatment of mycobacterial diseases. Berning, SE; Cook, JL; Curran-Everett, D; Goble, M; Huitt, GA; Iseman, MD; Nitta, AT; Peloquin, CA; Simone, PM, 2004) | 0.32 |
| " A dosage of antibiotics initially increased the heat production rate." | ( Chip calorimetry for fast and reliable evaluation of bactericidal and bacteriostatic treatments of biofilms. Buchholz, F; Harms, H; Lerchner, J; Maskow, T; Mertens, F; Wolf, A, 2010) | 0.36 |
| " We proposed a systematic classification scheme using FDA-approved drug labeling to assess the DILI potential of drugs, which yielded a benchmark dataset with 287 drugs representing a wide range of therapeutic categories and daily dosage amounts." | ( FDA-approved drug labeling for the study of drug-induced liver injury. Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V, 2011) | 0.37 |
| " Reducing dosing frequency to as little as once every other day (a four-fold decrease in dosing frequency) appeared as protective as twice per day." | ( Protection by low-dose kanamycin against noise-induced hearing loss in mice: dependence on dosing regimen and genetic background. Gagnon, PM; Montgomery, SC; Ohlemiller, KK; Rosen, AD; Rybak Rice, ME, 2011) | 0.68 |
| " The hybrid material combines the features of a chemical drug with photothermal physical sterilization which decreases the dosage of broad-spectrum antibiotic and the physical damage of biological systems." | ( Gold nanorod-covered kanamycin-loaded hollow SiO2 (HSKAu(rod)) nanocapsules for drug delivery and photothermal therapy on bacteria. Chen, XW; Hu, B; Wang, JH; Zhang, LP, 2013) | 0.39 |
| " To determine whether Rv3168 confers antibiotic resistance against kanamycin, we performed dose-response antibiotic resistance experiments using kanamycin." | ( Rv3168 phosphotransferase activity mediates kanamycin resistance in Mycobacterium tuberculosis. Ahn, JW; Kim, KJ, 2013) | 0.39 |
| " Dosing with dexamethasone following ototoxic insult shows promising yet variable response in hair cell survival." | ( Development of an ototoxicity model in the adult CBA/CaJ mouse and determination of a golden window of corticosteroid intervention for otoprotection. Fernandes, VT; Lin, VY, 2014) | 0.4 |
| "New, sensitive, and selective spectrofluorimetric method was developed for determination of three aminoglycoside drugs in different dosage forms, namely; neomycin sulfate (NEO), tobramycin (TOB) and kanamycin sulfate (KAN)." | ( Validated spectrofluorimetric method for determination of selected aminoglycosides. Ahmed, HM; Derayea, SM; Hammad, MA; Omar, MA, 2015) | 0.42 |
| " So, it seems possible that bicarbonate could help reduce aminoglycoside dosage at the same time that it might help lessen the damage to auditory ciliary cells in humans." | ( Bicarbonate enhances the in vitro antibiotic activity of kanamycin in Escherichia coli. Bustamante, VH; Gutiérrez-Huante, M; Martínez, H; Puente, JL; Sánchez, J, 2015) | 0.42 |
| "Therapeutic drug monitoring (TDM) of second-line antituberculosis drugs would allow for optimal individualized dosage adjustments and improve drug safety and therapeutic outcomes." | ( Pharmacokinetics of Second-Line Antituberculosis Drugs after Multiple Administrations in Healthy Volunteers. Chung, JY; Jang, IJ; Jang, K; Lee, JH; Moon, SJ; Oh, J; Park, JS; Park, SI; Song, J; Yoon, J; Yu, KS, 2015) | 0.42 |
| " This model, in combination with the limited sampling strategy developed, can be used in daily routine to guide dosing but also to assess AUC0-24h in phase 3 studies." | ( Limited sampling strategies for therapeutic drug monitoring of amikacin and kanamycin in patients with multidrug-resistant tuberculosis. Akkerman, OW; Alffenaar, JW; de Lange, WC; Dijkstra, JA; Kosterink, JG; Proost, JH; van Altena, R; van der Werf, TS, 2015) | 0.42 |
| " Stochastic PK/pharmacodynamic (PD) simulations were carried out to evaluate current regimen combinations and dosing guidelines in distinct patient strata." | ( Tuberculosis drugs' distribution and emergence of resistance in patient's lung lesions: A mechanistic model and tool for regimen and dose optimization. Bang, H; Barry, CE; Dartois, V; Eum, S; Fox, WS; Gupta, SV; Lee, M; Savic, RM; Shim, T; Strydom, N; Via, LE; Zimmerman, M, 2019) | 0.51 |
| Role | Description |
|---|---|
| bacterial metabolite | Any prokaryotic metabolite produced during a metabolic reaction in bacteria. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Class | Description |
|---|---|
| kanamycins | |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Pathway | Proteins | Compounds |
|---|---|---|
| Kanamycin Action Pathway | 1 | 4 |
| Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 3.9811 | 0.0096 | 10.5250 | 35.4813 | AID1479145 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 (µMol) | 133.0000 | 0.6315 | 4.4531 | 9.3000 | AID1473740 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 (µMol) | 133.0000 | 0.2000 | 5.6774 | 10.0000 | AID1473741 |
| Bile salt export pump | Homo sapiens (human) | IC50 (µMol) | 134.0000 | 0.1100 | 7.1903 | 10.0000 | AID1443980; AID1473738 |
| 3-oxoacyl-[acyl-carrier-protein] synthase 3 | Escherichia coli K-12 | IC50 (µMol) | 6.8000 | 6.8000 | 6.8000 | 6.8000 | AID1169517 |
| Gap junction beta-2 protein | Homo sapiens (human) | IC50 (µMol) | 10.4500 | 9.4000 | 9.4000 | 9.4000 | AID1385094; AID1740925 |
| Acyl-protein thioesterase 1 | Rattus norvegicus (Norway rat) | IC50 (µMol) | 110.0000 | 0.0570 | 0.0570 | 0.0570 | AID102989 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 (µMol) | 133.0000 | 2.4100 | 6.3433 | 10.0000 | AID1473739 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID560249 | Antibacterial activity against Staphylococcus aureus RN4220 harboring tet(L), dfrK gene by CLSI method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Novel ABC transporter gene, vga(C), located on a multiresistance plasmid from a porcine methicillin-resistant Staphylococcus aureus ST398 strain. |
| AID206015 | Minimum inhibitory concentration (MIC) was measured against Staphylococcus aureus ATCC 25923. | 1995 | Journal of medicinal chemistry, Nov-10, Volume: 38, Issue:23 | Synthesis and antimicrobial and toxicological studies of amino acid and peptide derivatives of kanamycin A and netilmicin. |
| AID293860 | Antibacterial activity against methicillin-resistant Staphylococcus aureus CMAH 0504 after 24 hrs by two fold dilution method | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6 | Synthesis of pseudopeptides based L-tryptophan as a potential antimicrobial agent. |
| AID725077 | Antimicrobial activity against Staphylococcus aureus after 12 to 18 hrs by micro-well dilution method | 2013 | European journal of medicinal chemistry, Jan, Volume: 59 | Synthesis and antibacterial and antifungal evaluation of some chalcone based sulfones and bisulfones. |
| AID126451 | Dissociation constant for binding to mitochondrial 12S rRNA construct M4 was determined | 2002 | Bioorganic & medicinal chemistry letters, Aug-19, Volume: 12, Issue:16 | Decoding region bubble size and aminoglycoside antibiotic binding. |
| AID164252 | Antibacterial activity expressed as MIC value was determined on Pseudomonas aeruginosa A-20717 organism | 1986 | Journal of medicinal chemistry, May, Volume: 29, Issue:5 | Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin. |
| AID1585670 | Antibacterial activity against methicillin-resistant Staphylococcus aureus assessed as zone of inhibition at 30 ug/mL after 24 hrs by agar disc diffusion method | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Discovery of novel arylethenesulfonyl fluorides as potential candidates against methicillin-resistant of Staphylococcus aureus (MRSA) for overcoming multidrug resistance of bacterial infections. |
| AID476723 | Antibacterial activity against Staphylococcus aureus ATCC 6538 after 24 hrs by colorimetric method using dye MTT | 2010 | Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7 | Synthesis, molecular modeling and biological evaluation of PSB as targeted antibiotics. |
| AID584121 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus ST398 isolate 11 containing apmA, erm(B), tet(L), tet(M), tet(K), dfrK, aadD, mecA, blaZ resistance genes by CLSI M31-A3 method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Novel apramycin resistance gene apmA in bovine and porcine methicillin-resistant Staphylococcus aureus ST398 isolates. |
| AID1077165 | Antibacterial activity against Pseudomonas aeruginosa after 12 hrs by MTT assay | 2014 | European journal of medicinal chemistry, Apr-09, Volume: 76 | Design and synthesis of 2-styryl of 5-Nitroimidazole derivatives and antimicrobial activities as FabH inhibitors. |
| AID599148 | Antibacterial activity against Pseudomonas fluorescens after 24 hrs by MTT assay | 2008 | European journal of medicinal chemistry, Mar, Volume: 43, Issue:3 | Synthesis, crystal structure and antimicrobial activity of deoxybenzoin derivatives from genistein. |
| AID1657552 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus incubated for 7 hrs by alamar Blue assay | |||
| AID524260 | Antibacterial activity against Escherichia coli NKE96 harboring deletion mutation in acrB protein | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Effect of NlpE overproduction on multidrug resistance in Escherichia coli. |
| AID544271 | Antimicrobial activity against Enterococcus faecalis NKH1 harboring pMG2200-like plasmid after 24 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Isolation of VanB-type Enterococcus faecalis strains from nosocomial infections: first report of the isolation and identification of the pheromone-responsive plasmids pMG2200, Encoding VanB-type vancomycin resistance and a Bac41-type bacteriocin, and pMG2 |
| AID470175 | Antitubercular activity against Mycobacterium tuberculosis H37Ra after 4 days by microplate alamar blue assay | 2009 | Journal of natural products, Nov, Volume: 72, Issue:11 | Diterpenes, sesquiterpenes, and a sesquiterpene-coumarin conjugate from Jatropha integerrima. |
| AID1191415 | Antimicrobial activity against Escherichia coli PCM 2561 (ATCC 8739, DSM 1576) after 16 to 20 hrs by broth micro-dilution method | 2015 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 25, Issue:3 | In vitro studies of antimicrobial activity of Gly-His-Lys conjugates as potential and promising candidates for therapeutics in skin and tissue infections. |
| AID501179 | Antimicrobial activity against methicillin sensitive Staphylococcus aureus 375 at 30 ug after 18 hrs by agar diffusion method | 2009 | Journal of natural products, Oct, Volume: 72, Issue:10 | Norselic acids A-E, highly oxidized anti-infective steroids that deter mesograzer predation, from the Antarctic sponge Crella sp. |
| AID1265793 | Antibacterial activity against Staphylococcus aureus NRS22 (USA 600) by microdilution method | 2015 | Journal of medicinal chemistry, Dec-10, Volume: 58, Issue:23 | Synthesis and Bioactivities of Kanamycin B-Derived Cationic Amphiphiles. |
| AID1478539 | Resistance index, ratio of MIC for Escherichia coli ATCC 35218 in 15th subculture to MIC for Escherichia coli ATCC 35218 in first subculture | 2017 | Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11 | Covalently linked kanamycin - Ciprofloxacin hybrid antibiotics as a tool to fight bacterial resistance. |
| AID1191414 | Antimicrobial activity against Escherichia coli DSM11250 (PCM2560, NTCC 10538) after 16 to 20 hrs by broth micro-dilution method | 2015 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 25, Issue:3 | In vitro studies of antimicrobial activity of Gly-His-Lys conjugates as potential and promising candidates for therapeutics in skin and tissue infections. |
| AID1167350 | Antibacterial activity against wild type Pseudomonas aeruginosa PAO1 after 18 to 24 hrs by two-fold broth microdilution method | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21 | Design, synthesis, and antibacterial properties of dual-ligand inhibitors of acetyl-CoA carboxylase. |
| AID1418826 | Antibacterial activity against Escherichia coli at 1 mg/ml after 48 hrs by agar well diffusion method | 2018 | Bioorganic & medicinal chemistry, 11-15, Volume: 26, Issue:21 | Simplified lipid II-binding antimicrobial peptides: Design, synthesis and antimicrobial activity of bioconjugates of nisin rings A and B with pore-forming peptides. |
| AID424601 | Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH378 (SCV-50) harboring -1 frameshift mutation at nucleotide 221 in rplF gene after 18 to 24 hrs by Etest strip assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID501183 | Antimicrobial activity against Escherichia coli 389 at 30 ug after 18 hrs by agar diffusion method | 2009 | Journal of natural products, Oct, Volume: 72, Issue:10 | Norselic acids A-E, highly oxidized anti-infective steroids that deter mesograzer predation, from the Antarctic sponge Crella sp. |
| AID749377 | Antimicrobial activity against Pseudomonas aeruginosa ATCC 27853 after 24 hrs by two fold serial dilution method | 2013 | Bioorganic & medicinal chemistry, Jun-01, Volume: 21, Issue:11 | Design, synthesis and antimicrobial activities evaluation of Schiff base derived from secnidazole derivatives as potential FabH inhibitors. |
| AID283548 | Antibacterial activity against Pseudomonas aeruginosa FE63 containing inactivated rplY and PA5471 genes by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides. |
| AID574785 | Antimycobacterial activity against extensively drug-resistant Mycobacterium tuberculosis isolate 2403 obtained from sputum of patient at 4 ug/ml by Bactec MGIT960 modified proportion method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Emergence and molecular characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates from the Delhi Region in India. |
| AID771507 | Antibacterial activity against Bacillus subtilis 168 by dilution technique | 2013 | European journal of medicinal chemistry, Oct, Volume: 68 | Synthesis and biological evaluation of novel ocotillol-type triterpenoid derivatives as antibacterial agents. |
| AID1731001 | Antibacterial activity against Escherichia coli DH5-alpha assessed as inhibition of bacterial growth measured after 18 hrs by two fold serial dilution method | 2021 | European journal of medicinal chemistry, Mar-05, Volume: 213 | Design and synthesis of mycobacterial pks13 inhibitors: Conformationally rigid tetracyclic molecules. |
| AID1868097 | Antibacterial activity against Staphylococcus aureus ATCC 9144 assessed as inhibition of visible bacterial growth incubated for 18 hrs by CLSI protocol based assay | 2022 | Journal of natural products, 05-27, Volume: 85, Issue:5 | Enceleamycins A-C, Furo-Naphthoquinones from |
| AID1905615 | Antimicrobial activity against kanamycin-resistant Escherichia coli ATCC 25922 | 2022 | Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7 | Novel β-Hairpin Antimicrobial Peptides Containing the β-Turn Sequence of -RRRF- Having High Cell Selectivity and Low Incidence of Drug Resistance. |
| AID625836 | Antibacterial activity against Escherichia coli by micro-broth dilution method | 2011 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 21, Issue:21 | Micelles catalyzed chemoselective synthesis 'in water' and biological evaluation of oxygen containing hetero-1,4-naphthoquinones as potential antifungal agents. |
| AID718269 | Antimicrobial activity against Escherichia coli DH5[alpha] | 2012 | Journal of natural products, Dec-28, Volume: 75, Issue:12 | Marthiapeptide A, an anti-infective and cytotoxic polythiazole cyclopeptide from a 60 L scale fermentation of the deep sea-derived Marinactinospora thermotolerans SCSIO 00652. |
| AID1562311 | Antimycobacterial activity against Mycobacterium smegmatis atR10 assessed as decrease in drug resistance development at 5 ug/disc after 2 to 3 days by paper disc method | 2019 | European journal of medicinal chemistry, Sep-15, Volume: 178 | Synthesis and antimycobacterial activity of imidazo[1,2-b][1,2,4,5]tetrazines. |
| AID477423 | Selectivity ratio of MIC for MBX-1090-resistant Staphylococcus aureus isolate d20A1 to MIC for Staphylococcus aureus NCTC 8325 | 2010 | Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6 | Efflux-mediated bis-indole resistance in Staphylococcus aureus reveals differential substrate specificities for MepA and MepR. |
| AID1455933 | Antibacterial activity against Escherichia coli after 48 hrs by broth micro-dilution method | 2017 | Journal of natural products, 02-24, Volume: 80, Issue:2 | Nabscessins A and B, Aminocyclitol Derivatives from Nocardia abscessus IFM 10029 |
| AID424587 | Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH377 (SCV-49) harboring +1 frameshift mutation at nucleotide 23 in rplF gene after 18 to 24 hrs by Etest strip assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID534341 | Antimicrobial activity against Burkholderia pseudomallei Bp227 harboring deleted (bpeAB-oprA)::FRT gene after 24 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | The BpeAB-OprB efflux pump of Burkholderia pseudomallei 1026b does not play a role in quorum sensing, virulence factor production, or extrusion of aminoglycosides but is a broad-spectrum drug efflux system. |
| AID1079937 | Severe hepatitis, defined as possibly life-threatening liver failure or through clinical observations. Value is number of references indexed. [column 'MASS' in source] | |||
| AID1477416 | Antibacterial activity against wild type Mycobacterium tuberculosis H37Rv grown in GAST/Fe medium measured on day 14 post inoculation by broth microdilution method | 2017 | Journal of medicinal chemistry, 12-28, Volume: 60, Issue:24 | Novel Antitubercular 6-Dialkylaminopyrimidine Carboxamides from Phenotypic Whole-Cell High Throughput Screening of a SoftFocus Library: Structure-Activity Relationship and Target Identification Studies. |
| AID69633 | Minimum inhibitory concentration was measured against Escherichia coli A 9632 | 1980 | Journal of medicinal chemistry, Jan, Volume: 23, Issue:1 | Aminoglycoside antibiotics. 3. Epimino derivatives of neamine, ribostamycin, and kanamycin B. |
| AID490133 | Antibacterial activity against Pseudomonas aeruginosa ATCC 13525 after 24 hrs by MTT assay | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Synthesis of some N-alkyl substituted urea derivatives as antibacterial and antifungal agents. |
| AID1738324 | Antibacterial activity against multidrug-resistant Staphylococcus aureus NRS271 assessed as reduction in bacterial growth incubated for 16 to 18 hrs by two fold serial dilution method | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Capsaicin derivatives with nitrothiophene substituents: Design, synthesis and antibacterial activity against multidrug-resistant S. aureus. |
| AID1906415 | Antibacterial activity against Escherichia coli ATCC 25922 assessed as reduction in microbial growth incubated for 24 hrs by microbroth dilution method | 2022 | European journal of medicinal chemistry, May-05, Volume: 235 | Amphiphilic cyclic peptide [W |
| AID625284 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatic failure | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID520870 | Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus saprophyticus isolate TSU47 isolated from genitourinary tracts of acute cystitis patient after 24 hrs at 35 degC by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Methicillin-resistant Staphylococcus saprophyticus isolates carrying staphylococcal cassette chromosome mec have emerged in urogenital tract infections. |
| AID1869574 | Bactericidal activity against Pseudomonas aeruginosa DSM 19880 assessed as reduction in colony count and measured after 3 days by agar diffusion assay | 2022 | Journal of natural products, 06-24, Volume: 85, Issue:6 | Triculamin: An Unusual Lasso Peptide with Potent Antimycobacterial Activity. |
| AID601495 | Antibacterial activity against Escherichia coli MTCC 739 at 30 ug/disc after 24 hrs | 2011 | European journal of medicinal chemistry, Jun, Volume: 46, Issue:6 | Evaluation of antioxidant and antimicrobial activities of Bergenin and its derivatives obtained by chemoenzymatic synthesis. |
| AID1182143 | Antitubercular activity against Mycobacterium smegmatis by checkerboard assay in presence of chlorpromazine-N-S-dioxide | 2014 | Bioorganic & medicinal chemistry, Aug-15, Volume: 22, Issue:16 | Pharmacologically active metabolites, combination screening and target identification-driven drug repositioning in antituberculosis drug discovery. |
| AID164250 | Antibacterial activity expressed as MIC value was determined on Pseudomonas aeruginosa A-20601 organism | 1986 | Journal of medicinal chemistry, May, Volume: 29, Issue:5 | Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin. |
| AID102989 | In vitro inhibition of lysosomal phospholipase activity for release of labeled lysophosphatidylcholine | 1991 | Journal of medicinal chemistry, Apr, Volume: 34, Issue:4 | New derivatives of kanamycin B obtained by modifications and substitutions in position 6''. 2. In vitro and computer-aided toxicological evaluation with respect to interactions with phosphatidylinositol. |
| AID1565719 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 33591 incubated for 18 hrs by two fold dilution method | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Scalable and cost-effective tosylation-mediated synthesis of antifungal and fungal diagnostic 6″-Modified amphiphilic kanamycins. |
| AID1337801 | Antibacterial activity against Bacillus subtilis NCIM 2079 measured after 12 hrs | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Quinolidene-rhodanine conjugates: Facile synthesis and biological evaluation. |
| AID524385 | Antibacterial activity against Escherichia coli NKE156 harboring deletion mutation in acrB protein and vector expressing acrD gene | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Effect of NlpE overproduction on multidrug resistance in Escherichia coli. |
| AID283530 | Antibacterial activity against Pseudomonas aeruginosa FE10 with inactivated nuoG gene by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides. |
| AID1905565 | Antimicrobial activity against Klebsiella pneumoniae ATCC 700603 assessed as reduction of bacterial growth incubated for 18 hrs by CLSI protocol based broth microdilution method | 2022 | Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7 | Novel β-Hairpin Antimicrobial Peptides Containing the β-Turn Sequence of -RRRF- Having High Cell Selectivity and Low Incidence of Drug Resistance. |
| AID592502 | Antibacterial activity against Legionella pneumophila Corby by microtiter plate assay | 2011 | Journal of natural products, Mar-25, Volume: 74, Issue:3 | Diversonol and blennolide derivatives from the endophytic fungus Microdiplodia sp.: absolute configuration of diversonol. |
| AID424594 | Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH349 (SCV-21) harboring -1 frameshift mutation at nucleotide 404 in rplF gene after 18 to 24 hrs by Etest strip assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID532990 | Antibacterial activity against Klebsiella pneumoniae NCIM 2883 assessed as growth inhibition in presence of 10 mM N-Acetylcysteine | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | N-acetylcysteine-mediated modulation of bacterial antibiotic susceptibility. |
| AID520875 | Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus saprophyticus isolates isolated from genitourinary tracts of acute cystitis patient after 24 hrs at 35 degC by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Methicillin-resistant Staphylococcus saprophyticus isolates carrying staphylococcal cassette chromosome mec have emerged in urogenital tract infections. |
| AID278247 | Antimicrobial activity against Salmonella enterica serovar Typhimurium S21-4 tolC::Kan with GyrA S83F, ParC S80I mutation | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials. |
| AID1627349 | Antibacterial activity against Acinetobacter baumannii ATCC BAA-1710D assessed as bacterial growth inhibition after 8 hrs by turbidimetric plate reader method | 2016 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 26, Issue:16 | 1α,2α-Epoxy-3β-hydroxy oleanolic acid derivatives regulation of the metabolism, haemolysis and β-lactamase gene expression in vitro and their structure-microbicidal activity relationship. |
| AID424828 | Antibacterial activity against kanamycin-resistant and fusidic acid-susceptible Staphylococcus aureus AH290 harboring duplication mutation at nucleotide 202-293 in rplF gene after 18 to 24 hrs by Etest strip assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID1164945 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus NRS 70 by microbroth dilution method | 2014 | Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20 | Synthesis, structure-activity relationship studies, and antibacterial evaluation of 4-chromanones and chalcones, as well as olympicin A and derivatives. |
| AID1653586 | Anti-leprotic activity against Mycobacterium leprae infected in BALB/c weanling mouse assessed as bacteria killing at 100 mg/kg, ip administrated for 60 days and measured after 1 year by Spearman-Karber technique analysis relative to control | 2019 | Bioorganic & medicinal chemistry, 07-01, Volume: 27, Issue:13 | Insights of synthetic analogues of anti-leprosy agents. |
| AID585015 | Antibacterial activity against Staphylococcus aureus ATCC 29213 | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Inhibition of bacterial multidrug resistance by celecoxib, a cyclooxygenase-2 inhibitor. |
| AID1254280 | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv in 7H9/ADC/Tween medium measured at day 14 by Alamar Blue assay | 2015 | Bioorganic & medicinal chemistry, Nov-15, Volume: 23, Issue:22 | Aminopyrazolo[1,5-a]pyrimidines as potential inhibitors of Mycobacterium tuberculosis: Structure activity relationships and ADME characterization. |
| AID326546 | Antimicrobial activity against Mycobacterium abscessus R61 isolate after 3 to 5 days by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | In Vitro activities of isepamicin, other aminoglycosides, and capreomycin against clinical isolates of rapidly growing mycobacteria in Taiwan. |
| AID311448 | Antitubercular activity against Mycobacterium tuberculosis H37Ra by alamar blue microplate assay | 2007 | Journal of natural products, Sep, Volume: 70, Issue:9 | Antimalarial and antituberculous poly-O-acylated jatrophane diterpenoids from Pedilanthus tithymaloides. |
| AID509450 | Antibacterial activity against Bacillus subtilis after 24 hrs by MTT assay | 2010 | European journal of medicinal chemistry, Sep, Volume: 45, Issue:9 | Design and synthesis of potent inhibitors of beta-ketoacyl-acyl carrier protein synthase III (FabH) as potential antibacterial agents. |
| AID424574 | Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH369 (SCV-41) harboring Gln115Leu mutation in fusA gene after 18 to 24 hrs by Etest strip assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID584327 | Antibacterial activity against speE deficient Escherichia coli JW0117-1 | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics. |
| AID257551 | Antibacterial activity against Klebsiella pneumoniae | 2005 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 15, Issue:23 | Synthesis and biological evaluation of novel (L)-alpha-amino acid methyl ester, heteroalkyl, and aryl substituted 1,4-naphthoquinone derivatives as antifungal and antibacterial agents. |
| AID1861192 | Antimycobacterial activity against drug-sensitive Mycobacterium tuberculosis assessed as mycobacterial growth inhibition | 2022 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 71 | Discovery and preclinical profile of sudapyridine (WX-081), a novel anti-tuberculosis agent. |
| AID610008 | Antibacterial activity against Staphylococcus aureus ATCC6538 after 24 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry, Aug-01, Volume: 19, Issue:15 | Synthesis, molecular modeling and biological evaluation of β-ketoacyl-acyl carrier protein synthase III (FabH) as novel antibacterial agents. |
| AID492159 | Antimicrobial activity against Staphylococcus aureus ATCC 6538 at 100 ug/well after 24 hrs at 37 degC by agar diffusion assay | 2010 | Journal of natural products, Jul-23, Volume: 73, Issue:7 | Cellular localization of clathridimine, an antimicrobial 2-aminoimidazole alkaloid produced by the Mediterranean calcareous sponge Clathrina clathrus. |
| AID1593376 | Inhibition of Pks13 D1644G/N1640K double mutant thioesterase domain in extensively drug-resistant Mycobacterium tuberculosis TF274 assessed as reduction in bacterial growth by microplate alamar blue assay | 2019 | Journal of medicinal chemistry, 04-11, Volume: 62, Issue:7 | Identification of Novel Coumestan Derivatives as Polyketide Synthase 13 Inhibitors against Mycobacterium tuberculosis. Part II. |
| AID283546 | Antibacterial activity against Pseudomonas aeruginosa KJ7106 with inactivated PA5471 gene by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides. |
| AID1624151 | Antitubercular activity against multidrug-resistant Mycobacterium tuberculosis isolate 3 after 7 days | 2019 | European journal of medicinal chemistry, Feb-15, Volume: 164 | Synthesis and evaluation of α-aminoacyl amides as antitubercular agents effective on drug resistant tuberculosis. |
| AID326539 | Antimicrobial activity against Mycobacterium abscessus NTU445 isolate after 3 to 5 days by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | In Vitro activities of isepamicin, other aminoglycosides, and capreomycin against clinical isolates of rapidly growing mycobacteria in Taiwan. |
| AID1287980 | Antibacterial activity against Bacillus subtilis after 18 hrs by broth dilution method | 2016 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 26, Issue:7 | Facile synthesis of 1,3-thiazolidin-4-ones as antitubercular agents. |
| AID381180 | Antibacterial activity against Staphylococcus aureus after 24 to 72 hrs by disk diffusion method | 1999 | Journal of natural products, Sep, Volume: 62, Issue:9 | Antimicrobial and antitumor activities of mycosporulone. |
| AID1905562 | Antimicrobial activity against Bacillus subtilis ATCC 23857 assessed as reduction of bacterial growth incubated for 18 hrs by CLSI protocol based broth microdilution method | 2022 | Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7 | Novel β-Hairpin Antimicrobial Peptides Containing the β-Turn Sequence of -RRRF- Having High Cell Selectivity and Low Incidence of Drug Resistance. |
| AID604258 | Antibacterial activity against Bacillus subtilis ATCC 6633 after 24 hrs by MTT colorimetric method | 2011 | Bioorganic & medicinal chemistry, Jul-01, Volume: 19, Issue:13 | 4-alkoxy-3-arylfuran-2(5H)-ones as inhibitors of tyrosyl-tRNA synthetase: synthesis, molecular docking and antibacterial evaluation. |
| AID584333 | Antibacterial activity against wild type Escherichia coli BW25113 absence of glutathione | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics. |
| AID524263 | Antibacterial activity against Escherichia coli NKE127 harboring deletion mutation in acrB and cpxAR protein | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Effect of NlpE overproduction on multidrug resistance in Escherichia coli. |
| AID278236 | Antimicrobial activity against Salmonella enterica serovar Typhimurium S21-2 with GyrA S83F, ParC S80I mutation | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials. |
| AID278542 | Antimicrobial activity against 60 min 1 M HCl-stressed Bifidobacterium longum P/N 601377 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID203329 | Antibacterial activity expressed as MIC value was determined on Serratia marcescens A-20019 organism | 1986 | Journal of medicinal chemistry, May, Volume: 29, Issue:5 | Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin. |
| AID587761 | Antimicrobial activity against wild type Mycobacterium ulcerans ATCC 19423 infected BALB/c mouse assessed as delay to time to foodpad swelling | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Using bioluminescence to monitor treatment response in real time in mice with Mycobacterium ulcerans infection. |
| AID1182136 | Antitubercular activity against Mycobacterium smegmatis by checkerboard assay in presence of chlorpromazine | 2014 | Bioorganic & medicinal chemistry, Aug-15, Volume: 22, Issue:16 | Pharmacologically active metabolites, combination screening and target identification-driven drug repositioning in antituberculosis drug discovery. |
| AID68016 | Antibacterial activity expressed as MIC value was determined on Enterobacter cloacae A-21006 organism | 1986 | Journal of medicinal chemistry, May, Volume: 29, Issue:5 | Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin. |
| AID424567 | Antibacterial activity against fusidic acid-resistant Staphylococcus aureus AH204 harboring deletion of nucleotide 203-231 in rplF gene after 18 to 24 hrs by Etest strip assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID521592 | Antibacterial activity against Salmonella enterica serovars virchow isolate 101591 at pH 7.0 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Aminoglycosides affect intracellular Salmonella enterica serovars typhimurium and virchow. |
| AID163060 | Minimum inhibitory concentration was measured against Proteus rettgeri A 9637 | 1980 | Journal of medicinal chemistry, Jan, Volume: 23, Issue:1 | Aminoglycoside antibiotics. 3. Epimino derivatives of neamine, ribostamycin, and kanamycin B. |
| AID749376 | Antimicrobial activity against Bacillus subtilis ATCC 530 after 24 hrs by two fold serial dilution method | 2013 | Bioorganic & medicinal chemistry, Jun-01, Volume: 21, Issue:11 | Design, synthesis and antimicrobial activities evaluation of Schiff base derived from secnidazole derivatives as potential FabH inhibitors. |
| AID1730992 | Antitubercular activity against multi drug resistance Mycobacterium tuberculosis V2475 by MABA assay | 2021 | European journal of medicinal chemistry, Mar-05, Volume: 213 | Design and synthesis of mycobacterial pks13 inhibitors: Conformationally rigid tetracyclic molecules. |
| AID1617681 | Antimicrobial activity against Enterococcus faecalis ATCC 29212 by CLSI based two-fold serial dilution method | |||
| AID278232 | Antimicrobial activity against Salmonella enterica serovar Typhimurium S21-1 GyrA S83F mutant | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials. |
| AID1869569 | Antibacterial activity against Klebsiella oxytoca DSM 5175 assessed as reduction in bacterial growth measured after 3 days by broth microdilution method | 2022 | Journal of natural products, 06-24, Volume: 85, Issue:6 | Triculamin: An Unusual Lasso Peptide with Potent Antimycobacterial Activity. |
| AID1132229 | Antibacterial activity against streptomycin, neomycin, kanamycin, gentamicin-resistant Escherichia coli 2964 assessed as growth inhibition by agar dilution method | 1978 | Journal of medicinal chemistry, Feb, Volume: 21, Issue:2 | Chemical modification of 1,4-diamino-1,4-dideoxy-3-O-(4-deoxy-4-propionamido-alpha-D-glucopyranosyl)-D-glucitol. |
| AID93906 | Minimum inhibitory concentration (MIC) was measured against Klebsiella pneumoniae. | 1995 | Journal of medicinal chemistry, Nov-10, Volume: 38, Issue:23 | Synthesis and antimicrobial and toxicological studies of amino acid and peptide derivatives of kanamycin A and netilmicin. |
| AID1890918 | Antimicrobial activity against Bacillus subtilis ATCC 23857 assessed as inhibition of microbial growth incubated for 16 hrs under shaking condition by microdilution assay | 2022 | Journal of natural products, 04-22, Volume: 85, Issue:4 | Expanding the Chemical Diversity of Fasamycin Via Genome Mining and Biocatalysis. |
| AID670727 | Antibacterial activity against Escherichia coli ATCC 25922/35128 after 24 hrs by MTT assay | 2012 | Bioorganic & medicinal chemistry, Jul-15, Volume: 20, Issue:14 | Design, synthesis and antimicrobial activities of nitroimidazole derivatives containing 1,3,4-oxadiazole scaffold as FabH inhibitors. |
| AID67885 | Minimum inhibitory concentration (MIC) was measured against Enterococcus faecalis ATCC 29212. | 1995 | Journal of medicinal chemistry, Nov-10, Volume: 38, Issue:23 | Synthesis and antimicrobial and toxicological studies of amino acid and peptide derivatives of kanamycin A and netilmicin. |
| AID1565720 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 incubated for 18 hrs by two fold dilution method | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Scalable and cost-effective tosylation-mediated synthesis of antifungal and fungal diagnostic 6″-Modified amphiphilic kanamycins. |
| AID625287 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatomegaly | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID278802 | Antimicrobial activity against recombinant Escherichia coli DH5-alpha expressing pBAD in the presence of arabinose | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Aph(3')-IIc, an aminoglycoside resistance determinant from Stenotrophomonas maltophilia. |
| AID278521 | Antimicrobial activity against Bifidobacterium animalis ATCC 27536 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID1348083 | Antimicrobial activity against Candida parapsilosis ATCC 90018 assessed as zone of inhibition at 50 ug per disc after 48 hrs by disc diffusion assay | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Synthesis of new 1-benzyl tetrahydropyridinylidene ammonium salts and their antimicrobial and anticellular activities. |
| AID1079944 | Benign tumor, proven histopathologically. Value is number of references indexed. [column 'T.BEN' in source] | |||
| AID278543 | Antimicrobial activity against 60 min 1 M HCl-stressed Bifidobacterium pseudolongum ATCC 25562 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID1629134 | Inhibition of cytosolic eukaryotic translation in rabbit reticulocyte S30 extract measured after 60 mins by coupled transcription/translation-based luciferase reporter gene assay | 2016 | Journal of medicinal chemistry, 09-08, Volume: 59, Issue:17 | Effects of 5-O-Ribosylation of Aminoglycosides on Antimicrobial Activity and Selective Perturbation of Bacterial Translation. |
| AID1077160 | Inhibition of Escherichia coli FabH expressed in Escherichia coli BL21 (DE3) after 25 mins | 2014 | European journal of medicinal chemistry, Apr-09, Volume: 76 | Design and synthesis of 2-styryl of 5-Nitroimidazole derivatives and antimicrobial activities as FabH inhibitors. |
| AID1265786 | Antibacterial activity against Listeria monocytogenes ATCC 19115 by microdilution method | 2015 | Journal of medicinal chemistry, Dec-10, Volume: 58, Issue:23 | Synthesis and Bioactivities of Kanamycin B-Derived Cationic Amphiphiles. |
| AID369073 | Antimicrobial activity against Escherichia coli ATCC 35218 after 24 hrs by MTT assay | 2009 | Bioorganic & medicinal chemistry, Feb-01, Volume: 17, Issue:3 | Synthesis, structure and antibacterial activity of new 2-(1-(2-(substituted-phenyl)-5-methyloxazol-4-yl)-3-(2-substitued-phenyl)-4,5-dihydro-1H-pyrazol-5-yl)-7-substitued-1,2,3,4-tetrahydroisoquinoline derivatives. |
| AID1869562 | Bactericidal activity against Mycobacterium smegmatis DSM 43080 assessed as reduction in colony count and measured after 3 days by agar diffusion assay | 2022 | Journal of natural products, 06-24, Volume: 85, Issue:6 | Triculamin: An Unusual Lasso Peptide with Potent Antimycobacterial Activity. |
| AID283534 | Antibacterial activity against Pseudomonas aeruginosa FE57 containing inactivated rplY gene with pARAL25 by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides. |
| AID1359443 | Antibacterial activity against Escherichia coli NCIM 2688 after 8 hrs by serial dilution method | 2018 | European journal of medicinal chemistry, May-25, Volume: 152 | Antibacterial and anti-TB tat-peptidomimetics with improved efficacy and half-life. |
| AID544276 | Antimicrobial activity against Enterococcus faecalis NKH6 harboring pMG2200-like and pMG2201-like plasmids after 24 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Isolation of VanB-type Enterococcus faecalis strains from nosocomial infections: first report of the isolation and identification of the pheromone-responsive plasmids pMG2200, Encoding VanB-type vancomycin resistance and a Bac41-type bacteriocin, and pMG2 |
| AID424343 | Antibacterial activity against fusidic acid-resistant Staphylococcus aureus AH206 harboring Arg464Ser mutation in fusA gene after 18 to 24 hrs by Etest strip assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID424597 | Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH339 (SCV-11) harboring -1 frameshift mutation at nucleotide 144 in rplF gene after 18 to 24 hrs by Etest strip assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID278528 | Antimicrobial activity against Bifidobacterium longum ATCC 15708 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID610007 | Antibacterial activity against Bacillus subtilis ATCC6633 after 24 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry, Aug-01, Volume: 19, Issue:15 | Synthesis, molecular modeling and biological evaluation of β-ketoacyl-acyl carrier protein synthase III (FabH) as novel antibacterial agents. |
| AID1491155 | Antibacterial activity against Enterococcus faecalis ATCC 29212 by CLSI method | 2017 | Journal of natural products, 05-26, Volume: 80, Issue:5 | Antimicrobial Spirotetronate Metabolites from Marine-Derived Micromonospora harpali SCSIO GJ089. |
| AID424829 | Antibacterial activity against kanamycin-resistant and fusidic acid-susceptible Staphylococcus aureus AH420 harboring deletion of nucleotide 72-80 in rplF gene after 18 to 24 hrs by Etest strip assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID293858 | Antibacterial activity against methicillin-resistant Staphylococcus aureus CMAH 0430 after 24 hrs by two fold dilution method | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6 | Synthesis of pseudopeptides based L-tryptophan as a potential antimicrobial agent. |
| AID387746 | Binding affinity to yeast tRNAPhe by quantitative ribonuclease V1 footprinting assay | 2008 | Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19 | Screening helix-threading peptides for RNA binding using a thiazole orange displacement assay. |
| AID404896 | Antibacterial activity against high-level gentamicin resistant Streptococcus pasteurianus SB28 isolate carrying transposon-borne resistance gene [aac(6')Ie-aph(2'')Ia] by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | High-level gentamicin resistance mediated by a Tn4001-like transposon in seven nonclonal hospital isolates of Streptococcus pasteurianus. |
| AID1326385 | Antibacterial activity against Bacillus subtilis P10A derived after 10 passage in presence of JBIR-100 after 16 to 18 hrs by microbroth dilution assay | 2016 | Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24 | Biological characterization of the hygrobafilomycin antibiotic JBIR-100 and bioinformatic insights into the hygrolide family of natural products. |
| AID521596 | Antibacterial activity against Salmonella enterica serovars Typhimurium ATCC 14028 at pH 7.0 by bioluminescence assay | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Aminoglycosides affect intracellular Salmonella enterica serovars typhimurium and virchow. |
| AID207043 | Antibacterial activity expressed as MIC value was determined on Staphylococcus aureus A-9537 organism | 1986 | Journal of medicinal chemistry, May, Volume: 29, Issue:5 | Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin. |
| AID1740925 | Inhibition of human Cx26 expressed in Escherichia coli LB2003 cells in medium containing 4 mM K+ and 500 uM IPTG by measuring cell growth after 18 hrs by plate reader | 2020 | European journal of medicinal chemistry, Oct-01, Volume: 203 | Amphiphilic aminoglycosides with increased selectivity for inhibition of connexin 43 (Cx43) hemichannels. |
| AID1056541 | Antibacterial activity against Escherichia coli ATCC 25922 by broth microdilution method | 2013 | Journal of natural products, Dec-27, Volume: 76, Issue:12 | Cytotoxic and antibacterial marfuraquinocins from the deep South China Sea-derived Streptomyces niveus SCSIO 3406. |
| AID1566486 | Binding affinity to biotinylated pre-miRNA-21 (unknown origin) by SPR analysis | 2019 | ACS medicinal chemistry letters, May-09, Volume: 10, Issue:5 | Tetracyclines as Inhibitors of Pre-microRNA Maturation: A Disconnection between RNA Binding and Inhibition. |
| AID424608 | Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH386 (SCV-58) harboring -1 frameshift mutation at nucleotide 90 in rplF gene after 18 to 24 hrs by Etest strip assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID774295 | Antimycobacterial activity against kanamycin-resistant Mycobacterium tuberculosis ATCC 35827 | 2013 | Journal of natural products, Oct-25, Volume: 76, Issue:10 | Chlorinated coumarins from the polypore mushroom Fomitopsis officinalis and their activity against Mycobacterium tuberculosis. |
| AID1482267 | Antibacterial activity against Escherichia coli MG1655 measured every 15 mins for 12 hrs | 2017 | Journal of medicinal chemistry, 05-11, Volume: 60, Issue:9 | Prediction of Antibiotic Interactions Using Descriptors Derived from Molecular Structure. |
| AID278229 | Antimicrobial activity against Salmonella enterica serovar Typhimurium S21 gyrA+ | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials. |
| AID1413326 | Antifungal activity against Candida pseudotropicalis YOGI | 2018 | MedChemComm, Jun-01, Volume: 9, Issue:6 | Antifungal amphiphilic kanamycins: new life for an old drug. |
| AID1287401 | Antimicrobial activity against Staphylococcus epidermidis after 24 hrs by serial two-fold microbroth dilution method | 2016 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 26, Issue:6 | One-pot synthesis and antimicrobial evaluation of novel 3-cyanopyridine derivatives of (-)-β-pinene. |
| AID1132226 | Antibacterial activity against Streptococcus faecalis 755 assessed as growth inhibition by agar dilution method | 1978 | Journal of medicinal chemistry, Feb, Volume: 21, Issue:2 | Chemical modification of 1,4-diamino-1,4-dideoxy-3-O-(4-deoxy-4-propionamido-alpha-D-glucopyranosyl)-D-glucitol. |
| AID278565 | Antimicrobial activity against 90 mins hydrogen peroxide-stressed Bifidobacterium longum R0175 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID424833 | Ratio of MIC for kanamycin-resistant Staphylococcus aureus harboring mutations in FusA gene to MIC for wild type kanamycin-susceptible Staphylococcus aureus AH001 | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID544058 | Antimicrobial activity against Shigella flexneri isolate C506 harboring sul1 to sul3 genes assessed as antibiotic resistance breakpoint by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Prevalence of sulfonamide resistance genes in bacterial isolates from manured agricultural soils and pig slurry in the United Kingdom. |
| AID1557265 | Antitubercular activity against resistant Mycobacterium tuberculosis harboring rrs C1402T mutant after 3 to 6 weeks | 2019 | MedChemComm, Aug-01, Volume: 10, Issue:8 | Drug-resistance in |
| AID524384 | Antibacterial activity against Escherichia coli NKE126 harboring deletion mutation in acrB and acrD protein | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Effect of NlpE overproduction on multidrug resistance in Escherichia coli. |
| AID424583 | Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH347 (SCV-19) harboring Arg659Ser mutation in fusA gene after 18 to 24 hrs by Etest strip assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID1695863 | Antibacterial activity against Pseudomonas fluorescens NCIM 2173 incubated for 24 hrs | 2019 | European journal of medicinal chemistry, Apr-15, Volume: 168 | Comprehensive review on the anti-bacterial activity of 1,2,3-triazole hybrids. |
| AID582763 | Antimicrobial activity against eaeA positive verocytotoxin-producing non-O157 Escherichia coli isolates obtained from human assessed as percentage of resistant isolates | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Antimicrobial resistance testing of verocytotoxin-producing Escherichia coli and first description of TEM-52 extended-spectrum β-lactamase in serogroup O26. |
| AID1132230 | Antibacterial activity against Pseudomonas aeruginosa 2956 assessed as growth inhibition by agar dilution method | 1978 | Journal of medicinal chemistry, Feb, Volume: 21, Issue:2 | Chemical modification of 1,4-diamino-1,4-dideoxy-3-O-(4-deoxy-4-propionamido-alpha-D-glucopyranosyl)-D-glucitol. |
| AID424582 | Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH331 (SCV-3) harboring Arg659His mutation in fusA gene after 18 to 24 hrs by Etest strip assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID1638887 | Antimicrobial activity against Staphylococcus aureus at 0.5 to 256 ug/ml after 24 hrs by two-fold serial micro dilution method | 2019 | Journal of natural products, 04-26, Volume: 82, Issue:4 | Inducing Secondary Metabolite Production by Co-culture of the Endophytic Fungus Phoma sp. and the Symbiotic Fungus Armillaria sp. |
| AID295897 | Antibacterial activity against Bacillus subtilis ATCC 6633 after 24 hrs by MTT method | 2007 | Bioorganic & medicinal chemistry, Jun-15, Volume: 15, Issue:12 | Synthesis, structure, and structure-activity relationship analysis of enamines as potential antibacterials. |
| AID477411 | Antibacterial activity against MBX-1090-resistant Staphylococcus aureus isolate d20A1 after 16 to 20 hrs by broth microdilution method | 2010 | Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6 | Efflux-mediated bis-indole resistance in Staphylococcus aureus reveals differential substrate specificities for MepA and MepR. |
| AID565231 | Antimicrobial activity against Mycobacterium chelonae 9917 harboring pZS01 carrying mspA gene by resazurine microtiter assay | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Role of porins in the susceptibility of Mycobacterium smegmatis and Mycobacterium chelonae to aldehyde-based disinfectants and drugs. |
| AID441925 | Antibacterial activity against Micrococcus luteus WT after 24 hrs by NCCLS method | 2009 | Journal of medicinal chemistry, Nov-12, Volume: 52, Issue:21 | Coordination chemistry based approach to lipophilic inhibitors of 1-deoxy-D-xylulose-5-phosphate reductoisomerase. |
| AID601494 | Antibacterial activity against Bacillus subtilis MTCC 441 at 30 ug/disc after 24 hrs | 2011 | European journal of medicinal chemistry, Jun, Volume: 46, Issue:6 | Evaluation of antioxidant and antimicrobial activities of Bergenin and its derivatives obtained by chemoenzymatic synthesis. |
| AID1562316 | Antimycobacterial activity against Mycobacterium smegmatis atR37 assessed as decrease in drug resistance development at 5 ug/disc after 2 to 3 days by paper disc method | 2019 | European journal of medicinal chemistry, Sep-15, Volume: 178 | Synthesis and antimycobacterial activity of imidazo[1,2-b][1,2,4,5]tetrazines. |
| AID257554 | Antibacterial activity against Staphylococcus aureus | 2005 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 15, Issue:23 | Synthesis and biological evaluation of novel (L)-alpha-amino acid methyl ester, heteroalkyl, and aryl substituted 1,4-naphthoquinone derivatives as antifungal and antibacterial agents. |
| AID278246 | Antimicrobial activity against Salmonella enterica serovar Typhimurium S21-4 acrAB::Kan with GyrA S83F, ParC S80I mutation | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials. |
| AID368421 | Antimicrobial activity against Escherichia coli KAM32 pSTV28 containing chloramphenicol-resistant vector by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | New plasmid-mediated fluoroquinolone efflux pump, QepA, found in an Escherichia coli clinical isolate. |
| AID203165 | Minimum inhibitory concentration measured against Serratia marcescens | 1995 | Journal of medicinal chemistry, Nov-10, Volume: 38, Issue:23 | Synthesis and antimicrobial and toxicological studies of amino acid and peptide derivatives of kanamycin A and netilmicin. |
| AID1202740 | Antimicrobial activity against Escherichia coli assessed as reduction in bacterial growth incubated for 48 hrs by microbroth dilution method | 2015 | Journal of natural products, Feb-27, Volume: 78, Issue:2 | Prenylated benzophenones from Triadenum japonicum. |
| AID523001 | Cytotoxicity against human 5637 cells assessed as mild induction of cell death by trypan blue exclusion assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Persistence of uropathogenic Escherichia coli in the face of multiple antibiotics. |
| AID1194692 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 33591 assessed as inhibition of microbial growth at 0.064 ug/ml to 125 ug/ml incubated at 37 degC for 20 hrs | 2015 | Bioorganic & medicinal chemistry letters, May-01, Volume: 25, Issue:9 | Three new fusidic acid derivatives and their antibacterial activity. |
| AID551749 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 after 12 to 18 hrs by twofold dilution method | 2011 | Bioorganic & medicinal chemistry, Jan-01, Volume: 19, Issue:1 | Synthesis and antibacterial activity study of a novel class of cationic anthraquinone analogs. |
| AID278238 | Antimicrobial activity against Salmonella enterica serovar Typhimurium S21-2 acrAB::Kan with GyrA S83F, ParC S80I mutation | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials. |
| AID278535 | Antimicrobial activity against 60 min 1 M HCl-stressed Bifidobacterium bifidum R0071 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID771509 | Antibacterial activity against community associated methicillin-resistant Staphylococcus aureus USA300 by dilution technique | 2013 | European journal of medicinal chemistry, Oct, Volume: 68 | Synthesis and biological evaluation of novel ocotillol-type triterpenoid derivatives as antibacterial agents. |
| AID1132233 | Antibacterial activity against streptomycin, neomycin, kanamycin, gentamicin, tobramycin-resistant Klebsiella 2922 assessed as growth inhibition by agar dilution method | 1978 | Journal of medicinal chemistry, Feb, Volume: 21, Issue:2 | Chemical modification of 1,4-diamino-1,4-dideoxy-3-O-(4-deoxy-4-propionamido-alpha-D-glucopyranosyl)-D-glucitol. |
| AID404898 | Antibacterial activity against high-level gentamicin resistant Streptococcus pasteurianus SB33 isolate carrying transposon-borne resistance gene [aac(6')Ie-aph(2'')Ia] by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | High-level gentamicin resistance mediated by a Tn4001-like transposon in seven nonclonal hospital isolates of Streptococcus pasteurianus. |
| AID1436939 | Antibacterial activity against Escherichia coli ATCC 25292 after 8 hrs | 2017 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 27, Issue:4 | Quinolidene based monocarbonyl curcumin analogues as promising antimycobacterial agents: Synthesis and molecular docking study. |
| AID1491151 | Antibacterial activity against Bacillus subtilis BS01 by CLSI method | 2017 | Journal of natural products, 05-26, Volume: 80, Issue:5 | Antimicrobial Spirotetronate Metabolites from Marine-Derived Micromonospora harpali SCSIO GJ089. |
| AID1868101 | Antibacterial activity against Micrococcus luteus ATCC 9341 assessed as inhibition of visible bacterial growth incubated for 18 hrs by CLSI protocol based assay | 2022 | Journal of natural products, 05-27, Volume: 85, Issue:5 | Enceleamycins A-C, Furo-Naphthoquinones from |
| AID1710554 | Displacement of F-neo from premature miRNA21 (unknown origin) at 100 nM by fluorescence assay relative to control | 2018 | MedChemComm, Jul-01, Volume: 9, Issue:7 | Targeting miRNA by tunable small molecule binders: peptidic aminosugar mediated interference in miR-21 biogenesis reverts epithelial to mesenchymal transition. |
| AID1585677 | Antibiofilm activity against methicillin-resistant Staphylococcus aureus planktonic biofilm assessed as optical density at 492 nm at MIC after 24 hrs by crystal violet staining-based UV-visible spectrophotometric analysis | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Discovery of novel arylethenesulfonyl fluorides as potential candidates against methicillin-resistant of Staphylococcus aureus (MRSA) for overcoming multidrug resistance of bacterial infections. |
| AID368420 | Antimicrobial activity against Escherichia coli KAM32 pHPA containing mutated GyrA gene by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | New plasmid-mediated fluoroquinolone efflux pump, QepA, found in an Escherichia coli clinical isolate. |
| AID1629127 | Antimicrobial activity against Klebsiella pneumoniae ATCC 10031 measured after 24 hrs by double-dilution method | 2016 | Journal of medicinal chemistry, 09-08, Volume: 59, Issue:17 | Effects of 5-O-Ribosylation of Aminoglycosides on Antimicrobial Activity and Selective Perturbation of Bacterial Translation. |
| AID486725 | Antibacterial activity against Bacillus subtilis ATCC 6633 after 24 hrs by MTT assay | 2010 | European journal of medicinal chemistry, Jun, Volume: 45, Issue:6 | Synthesis, structure and structure-activity relationship analysis of caffeic acid amides as potential antimicrobials. |
| AID1663464 | Antibacterial activity against Bacillus subtilis ATCC 6633 incubated for 16 hrs by broth microdilution method | 2020 | Journal of natural products, 06-26, Volume: 83, Issue:6 | Antibacterial Pentacyclic Polyketides from a Soil-Derived |
| AID1869573 | Antibacterial activity against Pseudomonas aeruginosa DSM 19880 assessed as reduction in bacterial growth measured after 3 days by broth microdilution method | 2022 | Journal of natural products, 06-24, Volume: 85, Issue:6 | Triculamin: An Unusual Lasso Peptide with Potent Antimycobacterial Activity. |
| AID529885 | Antibacterial activity against Staphylococcus aureus RN4220 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Discovery and characterization of QPT-1, the progenitor of a new class of bacterial topoisomerase inhibitors. |
| AID1710563 | Antibacterial activity against Staphylococcus aureus ATCC 25923 assessed as reduction in bacterial growth incubated for 15 to 20 hrs by broth microdilution method | 2018 | MedChemComm, Jul-01, Volume: 9, Issue:7 | Targeting miRNA by tunable small molecule binders: peptidic aminosugar mediated interference in miR-21 biogenesis reverts epithelial to mesenchymal transition. |
| AID1303881 | Antibacterial activity against multidrug resistant Enterococcus faecium NCTC 7171 (ATCC 19434) assessed as reduction in bacterial growth incubated for 6 to 8 hrs | 2016 | Bioorganic & medicinal chemistry letters, 07-01, Volume: 26, Issue:13 | GroEL/ES inhibitors as potential antibiotics. |
| AID1359445 | Antibacterial activity against Enterobacter sp. NCIM 5392 after 8 hrs by serial dilution method | 2018 | European journal of medicinal chemistry, May-25, Volume: 152 | Antibacterial and anti-TB tat-peptidomimetics with improved efficacy and half-life. |
| AID207038 | Antibacterial activity expressed as MIC value was determined on Staphylococcus aureus A-20240 organism | 1986 | Journal of medicinal chemistry, May, Volume: 29, Issue:5 | Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin. |
| AID1296449 | Antimycobacterial activity against Mycobacterium tuberculosis H37Ra assessed as growth inhibition at 5 ug/ml preincubated for 1 hr followed by radiolabeling with [14C]-uracil, [14C]-methionine for 24 hrs | 2016 | Journal of medicinal chemistry, Mar-24, Volume: 59, Issue:6 | Development of 3,5-Dinitrobenzylsulfanyl-1,3,4-oxadiazoles and Thiadiazoles as Selective Antitubercular Agents Active Against Replicating and Nonreplicating Mycobacterium tuberculosis. |
| AID1861191 | Antimycobacterial activity against multidrug-resistant Mycobacterium tuberculosis assessed as mycobacterial growth inhibition | 2022 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 71 | Discovery and preclinical profile of sudapyridine (WX-081), a novel anti-tuberculosis agent. |
| AID586085 | Antimicrobial activity against verocytotoxin-producing Escherichia coli isolate O157 obtained from human assessed as percentage of resistant isolates by disk diffusion method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Antimicrobial resistance testing of verocytotoxin-producing Escherichia coli and first description of TEM-52 extended-spectrum β-lactamase in serogroup O26. |
| AID1869564 | Bactericidal activity against Bacillus cereus DSM 31 assessed as reduction in colony count and measured after 3 days by agar diffusion assay | 2022 | Journal of natural products, 06-24, Volume: 85, Issue:6 | Triculamin: An Unusual Lasso Peptide with Potent Antimycobacterial Activity. |
| AID750185 | Antibacterial activity against Escherichia coli ATCC 35218 assessed as growth inhibition after 24 hrs by two-fold serial dilution method | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Synthesis and antimicrobical evaluation of a novel class of 1,3,4-thiadiazole: derivatives bearing 1,2,4-triazolo[1,5-a]pyrimidine moiety. |
| AID563511 | Antimicrobial activity against cetylpyridinium chloride-resistant Serratia marcescens HMS011 harboring plasmid STV28 expressing sdeB gene by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Mutational upregulation of a resistance-nodulation-cell division-type multidrug efflux pump, SdeAB, upon exposure to a biocide, cetylpyridinium chloride, and antibiotic resistance in Serratia marcescens. |
| AID299666 | Antibacterial activity against Micrococcus luteus CMCC(B)28001 by broth microdilution method | 2007 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 17, Issue:15 | Synthesis and evaluation of amphiphilic cationic quinine-derived for antibacterial activity against methicillin-resistant Staphylococcus aureus. |
| AID1539487 | Antibacterial activity against Salmonella enteritidis ATCC 14028 infected in mouse J774 cells assessed as reduction in intracellular bacterial cells at 2 times MIC incubated for 24 hrs followed by re-plating on TSA plate and measured after 18 to 22 hrs re | |||
| AID1869568 | Bactericidal activity against Staphylococcus aureus DSM 20231 assessed as reduction in colony count and measured after 3 days by agar diffusion assay | 2022 | Journal of natural products, 06-24, Volume: 85, Issue:6 | Triculamin: An Unusual Lasso Peptide with Potent Antimycobacterial Activity. |
| AID1478520 | Ratio of MIC for aminoglycosides-resistant Escherichia coli BL21 harboring pET11d encode for APH(3')-2b resistance enzyme to MIC for Escherichia coli BL21 | 2017 | Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11 | Covalently linked kanamycin - Ciprofloxacin hybrid antibiotics as a tool to fight bacterial resistance. |
| AID1413335 | Antifungal activity against resistant Candida parapsilosis | 2018 | MedChemComm, Jun-01, Volume: 9, Issue:6 | Antifungal amphiphilic kanamycins: new life for an old drug. |
| AID1348086 | Antimicrobial activity against Staphylococcus epidermidis ATCC 12228 assessed as zone of inhibition at 50 ug per disc after 24 hrs by disc diffusion assay | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Synthesis of new 1-benzyl tetrahydropyridinylidene ammonium salts and their antimicrobial and anticellular activities. |
| AID434368 | Antibacterial activity against Klebsiella pneumoniae ATCC 27736 after 24 hrs by broth microdilution method | 2009 | European journal of medicinal chemistry, Aug, Volume: 44, Issue:8 | Design, synthesis and biological evaluation of novel nitrogen and sulfur containing hetero-1,4-naphthoquinones as potent antifungal and antibacterial agents. |
| AID544274 | Antimicrobial activity against Enterococcus faecalis NKH4 harboring pMG2200-like and pMG2201-like plasmids after 24 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Isolation of VanB-type Enterococcus faecalis strains from nosocomial infections: first report of the isolation and identification of the pheromone-responsive plasmids pMG2200, Encoding VanB-type vancomycin resistance and a Bac41-type bacteriocin, and pMG2 |
| AID1293898 | Antibacterial activity against Escherichia coli after 18 hrs by broth dilution method | 2016 | Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9 | Novel tetrazoloquinoline-rhodanine conjugates: Highly efficient synthesis and biological evaluation. |
| AID486727 | Antibacterial activity against Staphylococcus aureus ATCC 6538 after 24 hrs by MTT assay | 2010 | European journal of medicinal chemistry, Jun, Volume: 45, Issue:6 | Synthesis, structure and structure-activity relationship analysis of caffeic acid amides as potential antimicrobials. |
| AID573967 | Antibacterial activity against Cj1211-negative Campylobacter jejuni harboring aphA3 and tet(O) genes | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Role of Cj1211 in natural transformation and transfer of antibiotic resistance determinants in Campylobacter jejuni. |
| AID1636440 | Drug activation in human Hep3B cells assessed as human CYP2D6-mediated drug metabolism-induced cytotoxicity measured as decrease in cell viability at 300 uM pre-incubated with BSO for 18 hrs followed by incubation with compound for 3 hrs in presence of NA | 2016 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 26, Issue:16 | Development of a cell viability assay to assess drug metabolite structure-toxicity relationships. |
| AID326549 | Antimicrobial activity against Mycobacterium abscessus R49 isolate after 3 to 5 days by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | In Vitro activities of isepamicin, other aminoglycosides, and capreomycin against clinical isolates of rapidly growing mycobacteria in Taiwan. |
| AID424581 | Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH329 (SCV-1) harboring Arg659Cys mutation in fusA gene after 18 to 24 hrs by Etest strip assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID373987 | Antimicrobial activity against azide-resistant aac(6')-Ib-cr deficient Escherichia coli J53 qnrA1 bearing pHS4 transconjugant from Enterobacter cloacae 91 by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Prevalence and expression of the plasmid-mediated quinolone resistance determinant qnrA1. |
| AID625279 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for bilirubinemia | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID610005 | Antibacterial activity against Escherichia coli ATCC35218 after 24 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry, Aug-01, Volume: 19, Issue:15 | Synthesis, molecular modeling and biological evaluation of β-ketoacyl-acyl carrier protein synthase III (FabH) as novel antibacterial agents. |
| AID293873 | Antimicrobial activity against Micrococcus luteus CMCC(B) 28001 after 24 hrs by two fold dilution method | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6 | Synthesis of pseudopeptides based L-tryptophan as a potential antimicrobial agent. |
| AID1905563 | Antimicrobial activity against Staphylococcus epidermidis ATCC 12228 assessed as reduction of bacterial growth incubated for 18 hrs by CLSI protocol based broth microdilution method | 2022 | Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7 | Novel β-Hairpin Antimicrobial Peptides Containing the β-Turn Sequence of -RRRF- Having High Cell Selectivity and Low Incidence of Drug Resistance. |
| AID1105399 | Antibacterial activity against Staphylococcus aureus MTCC 3160 assessed as growth inhibition at 25 ug/disk after 24 hr by disk diffusion method | 2013 | European journal of medicinal chemistry, Jan, Volume: 59 | Microwave synthesis, characterization and bio-efficacy evaluation of novel chalcone based 6-carbethoxy-2-cyclohexen-1-one and 2H-indazol-3-ol derivatives. |
| AID1191412 | Antimicrobial activity against Staphylococcus aureus PCM 2054 (ATCC 25923) after 16 to 20 hrs by broth micro-dilution method | 2015 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 25, Issue:3 | In vitro studies of antimicrobial activity of Gly-His-Lys conjugates as potential and promising candidates for therapeutics in skin and tissue infections. |
| AID599149 | Antibacterial activity against Staphylococcus aureus after 24 hrs by MTT assay | 2008 | European journal of medicinal chemistry, Mar, Volume: 43, Issue:3 | Synthesis, crystal structure and antimicrobial activity of deoxybenzoin derivatives from genistein. |
| AID424595 | Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH374 (SCV-46) harboring -5 frameshift mutation at nucleotide 236-240 in rplF gene after 18 to 24 hrs by Etest strip assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID1413322 | Antibacterial activity against Staphylococcus aureus ATCC 25923 | 2018 | MedChemComm, Jun-01, Volume: 9, Issue:6 | Antifungal amphiphilic kanamycins: new life for an old drug. |
| AID774296 | Antimycobacterial activity against streptomycin-resistant Mycobacterium tuberculosis ATCC 35820 | 2013 | Journal of natural products, Oct-25, Volume: 76, Issue:10 | Chlorinated coumarins from the polypore mushroom Fomitopsis officinalis and their activity against Mycobacterium tuberculosis. |
| AID610006 | Antibacterial activity against Pseudomonas aeruginosa ATCC13525 after 24 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry, Aug-01, Volume: 19, Issue:15 | Synthesis, molecular modeling and biological evaluation of β-ketoacyl-acyl carrier protein synthase III (FabH) as novel antibacterial agents. |
| AID424604 | Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH383 (SCV-55) harboring TAA stop codon at nucleotide 139 in rplF gene after 18 to 24 hrs by Etest strip assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID532986 | Antibacterial activity against Pseudomonas aeruginosa NCIM 5029 | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | N-acetylcysteine-mediated modulation of bacterial antibiotic susceptibility. |
| AID551751 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis ATCC 51299 after 12 to 18 hrs by twofold dilution method | 2011 | Bioorganic & medicinal chemistry, Jan-01, Volume: 19, Issue:1 | Synthesis and antibacterial activity study of a novel class of cationic anthraquinone analogs. |
| AID424614 | Antibacterial activity against kanamycin-resistant and fusidic acid-susceptible Staphylococcus aureus AH291 harboring Arg659His mutation in fusA gene after 18 to 24 hrs by Etest strip assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID145298 | Antibacterial activity against Mycobacterium tuberculosis H37Rv. | 1985 | Journal of medicinal chemistry, Dec, Volume: 28, Issue:12 | Synthesis and antibacterial activity of 2,2'-dithiobis(benzamide) derivatives against Mycobacterium species. |
| AID588212 | Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in rodents | 2010 | Chemical research in toxicology, Jan, Volume: 23, Issue:1 | Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. |
| AID532981 | Antibacterial activity against Escherichia coli DH5alpha | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | N-acetylcysteine-mediated modulation of bacterial antibiotic susceptibility. |
| AID1585465 | Antibacterial activity against Escherichia coli AB1157 measured after 16 hrs | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Design, synthesis and evaluation of hybrid of tetrahydrocarbazole with 2,4-diaminopyrimidine scaffold as antibacterial agents. |
| AID1905561 | Antimicrobial activity against Staphylococcus aureus ATCC 25923 assessed as reduction of bacterial growth incubated for 18 hrs by CLSI protocol based broth microdilution method | 2022 | Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7 | Novel β-Hairpin Antimicrobial Peptides Containing the β-Turn Sequence of -RRRF- Having High Cell Selectivity and Low Incidence of Drug Resistance. |
| AID584331 | Antibacterial activity against tolC, speE deficient Escherichia coli GD106 | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics. |
| AID1265794 | Antibacterial activity against Staphylococcus epidermidis ATCC 12228 by microdilution method | 2015 | Journal of medicinal chemistry, Dec-10, Volume: 58, Issue:23 | Synthesis and Bioactivities of Kanamycin B-Derived Cationic Amphiphiles. |
| AID759041 | Antibacterial activity against Bacillus subtilis assessed as survival after 24 hrs by MTT assay | 2013 | European journal of medicinal chemistry, Jul, Volume: 65 | Potentiating 1-(2-hydroxypropyl)-2-styryl-5-nitroimidazole derivatives against antibacterial agents: design, synthesis and biology analysis. |
| AID278555 | Antimicrobial activity against 90 mins oxgall-stressed Bifidobacterium longum P/N 601377 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID1413329 | Antifungal activity against Candida tropicalis 95-41 | 2018 | MedChemComm, Jun-01, Volume: 9, Issue:6 | Antifungal amphiphilic kanamycins: new life for an old drug. |
| AID1890842 | Antimycobacterial activity against wild type Mycobacterium smegmatis mc2 155 assessed as inhibition of mycobacterial growth incubated for 3 to 5 days by resazurin microtiter assay | 2022 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 64 | Design, synthesis and antibacterial activity against pathogenic mycobacteria of conjugated hydroxamic acids, hydrazides and O-alkyl/O-acyl protected hydroxamic derivatives. |
| AID1562315 | Antimycobacterial activity against Mycobacterium smegmatis atR33 assessed as decrease in drug resistance development at 5 ug/disc after 2 to 3 days by paper disc method | 2019 | European journal of medicinal chemistry, Sep-15, Volume: 178 | Synthesis and antimycobacterial activity of imidazo[1,2-b][1,2,4,5]tetrazines. |
| AID1306201 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 18 hrs by microbroth dilution assay | 2016 | Bioorganic & medicinal chemistry, 07-15, Volume: 24, Issue:14 | The influence of halogen substituents on the biological properties of sulfur-containing flavonoids. |
| AID405080 | Antimicrobial activity against Citrobacter freundii 33587 isolate by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Biochemical characterization of PER-2 and genetic environment of blaPER-2. |
| AID1882861 | Antibacterial activity against Escherichia coli K12 expressing modified luxABCDE genes assessed as reduction in bacterial growth by measuring reduction in optical density at 40 uM incubated for 16 hrs by microplate reader analysis | 2022 | European journal of medicinal chemistry, Jul-05, Volume: 237 | The role of the maleimide ring system on the structure-activity relationship of showdomycin. |
| AID1478529 | Ratio of MIC for aminoglycosides-resistant Escherichia coli BL21 harboring pSF815 encode for bifunctional AAC(6')/APH(2\\\\\\\\\\) resistance enzyme to MIC for Escherichia coli BL21 | 2017 | Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11 | Covalently linked kanamycin - Ciprofloxacin hybrid antibiotics as a tool to fight bacterial resistance. |
| AID278564 | Antimicrobial activity against 90 mins hydrogen peroxide-stressed Bifidobacterium longum ATCC 15708 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID1265798 | Antibacterial activity against Escherichia coli MC1061 by microdilution method | 2015 | Journal of medicinal chemistry, Dec-10, Volume: 58, Issue:23 | Synthesis and Bioactivities of Kanamycin B-Derived Cationic Amphiphiles. |
| AID1562308 | Antimycobacterial activity against Mycobacterium smegmatis atR2 assessed as decrease in drug resistance development at 5 ug/disc after 2 to 3 days by paper disc method | 2019 | European journal of medicinal chemistry, Sep-15, Volume: 178 | Synthesis and antimycobacterial activity of imidazo[1,2-b][1,2,4,5]tetrazines. |
| AID509451 | Antibacterial activity against Staphylococcus aureus after 24 hrs by MTT assay | 2010 | European journal of medicinal chemistry, Sep, Volume: 45, Issue:9 | Design and synthesis of potent inhibitors of beta-ketoacyl-acyl carrier protein synthase III (FabH) as potential antibacterial agents. |
| AID348957 | Antibacterial activity against Staphylococcus aureus after 24 hrs by MTT assay | 2008 | European journal of medicinal chemistry, Jul, Volume: 43, Issue:7 | Synthesis and antimicrobial activities of 7-O-modified genistein derivatives. |
| AID530287 | Antimicrobial activity against PR-39-resistant sbmA-deficient Salmonella enterica serovar Typhimurium LT2 DA12088 by Etest | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Mechanism and fitness costs of PR-39 resistance in Salmonella enterica serovar Typhimurium LT2. |
| AID299671 | Antibacterial activity against Staphylococcus aureus by disk diffusion method | 2007 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 17, Issue:15 | Synthesis and evaluation of amphiphilic cationic quinine-derived for antibacterial activity against methicillin-resistant Staphylococcus aureus. |
| AID1765578 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 incubated for 18 hrs by CLSI based broth dilution method | 2021 | Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15 | Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice. |
| AID278558 | Antimicrobial activity against 90 mins hydrogen peroxide-stressed Bifidobacterium animalis ATCC 27536 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID1490879 | Antimycobacterial activity against Mycobacterium smegmatis after 24 hrs by microplate alamar blue assay | 2017 | Journal of natural products, 05-26, Volume: 80, Issue:5 | ent-Abietane and Tigliane Diterpenoids from the Roots of Euphorbia fischeriana and Their Inhibitory Effects against Mycobacterium smegmatis. |
| AID569260 | Antimicrobial activity against Staphylococcus aureus | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Synthesis and evaluation of anti-tubercular activity of new dithiocarbamate sugar derivatives. |
| AID30395 | Minimum inhibitory concentration (MIC) was measured against Acinetobacter baumanni ATCC 19606. | 1995 | Journal of medicinal chemistry, Nov-10, Volume: 38, Issue:23 | Synthesis and antimicrobial and toxicological studies of amino acid and peptide derivatives of kanamycin A and netilmicin. |
| AID1262360 | Antibacterial activity against clinical isolate Gram-negative Pseudomonas syringae after 24 hrs by agar diffusion assay | 2015 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 25, Issue:24 | PPL catalyzed four-component PASE synthesis of 5-monosubstituted barbiturates: Structure and pharmacological properties. |
| AID275056 | Antibacterial activity against Escherichia coli pTMV19 in presence of mevalonate | 2006 | Journal of medicinal chemistry, Dec-14, Volume: 49, Issue:25 | Isoprenoid biosynthesis as a drug target: bisphosphonate inhibition of Escherichia coli K12 growth and synergistic effects of fosmidomycin. |
| AID278235 | Antimicrobial activity against Salmonella enterica serovar Typhimurium S21-1 tolC::Kan with GyrA S83F mutation | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials. |
| AID1447478 | Antibacterial activity against Pseudomonas aeruginosa PAO1 after 18 hrs by microtiter dilution assay | 2017 | Journal of medicinal chemistry, 05-11, Volume: 60, Issue:9 | Amphiphilic Tobramycin-Lysine Conjugates Sensitize Multidrug Resistant Gram-Negative Bacteria to Rifampicin and Minocycline. |
| AID520874 | Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus saprophyticus isolate TSU90 isolated from genitourinary tracts of acute cystitis patient after 24 hrs at 35 degC by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Methicillin-resistant Staphylococcus saprophyticus isolates carrying staphylococcal cassette chromosome mec have emerged in urogenital tract infections. |
| AID68538 | Minimum inhibitory concentration (MIC) was measured against Enterobacter cloacae. | 1995 | Journal of medicinal chemistry, Nov-10, Volume: 38, Issue:23 | Synthesis and antimicrobial and toxicological studies of amino acid and peptide derivatives of kanamycin A and netilmicin. |
| AID295898 | Antibacterial activity against Escherichia coli ATCC 35218 after 24 hrs by MTT method | 2007 | Bioorganic & medicinal chemistry, Jun-15, Volume: 15, Issue:12 | Synthesis, structure, and structure-activity relationship analysis of enamines as potential antibacterials. |
| AID540213 | Half life in human after iv administration | 2008 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7 | Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. |
| AID592501 | Antifungal activity against Microbotryum violaceum assessed as zone of inhibition measured as radius at 50 ug by agar diffusion assay | 2011 | Journal of natural products, Mar-25, Volume: 74, Issue:3 | Diversonol and blennolide derivatives from the endophytic fungus Microdiplodia sp.: absolute configuration of diversonol. |
| AID774300 | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 by microplate Alamar blue assay | 2013 | Journal of natural products, Oct-25, Volume: 76, Issue:10 | Chlorinated coumarins from the polypore mushroom Fomitopsis officinalis and their activity against Mycobacterium tuberculosis. |
| AID1593375 | Inhibition of Pks13 D1644G/N1640K double mutant thioesterase domain in multidrug-resistant Mycobacterium tuberculosis KZN494 assessed as reduction in bacterial growth by microplate alamar blue assay | 2019 | Journal of medicinal chemistry, 04-11, Volume: 62, Issue:7 | Identification of Novel Coumestan Derivatives as Polyketide Synthase 13 Inhibitors against Mycobacterium tuberculosis. Part II. |
| AID441924 | Antibacterial activity against Bacillus anthracis Sterne after 24 hrs by NCCLS method | 2009 | Journal of medicinal chemistry, Nov-12, Volume: 52, Issue:21 | Coordination chemistry based approach to lipophilic inhibitors of 1-deoxy-D-xylulose-5-phosphate reductoisomerase. |
| AID670726 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 after 24 hrs by MTT assay | 2012 | Bioorganic & medicinal chemistry, Jul-15, Volume: 20, Issue:14 | Design, synthesis and antimicrobial activities of nitroimidazole derivatives containing 1,3,4-oxadiazole scaffold as FabH inhibitors. |
| AID326551 | Antimicrobial activity against Mycobacterium fortuitum V13 isolate after 3 to 5 days by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | In Vitro activities of isepamicin, other aminoglycosides, and capreomycin against clinical isolates of rapidly growing mycobacteria in Taiwan. |
| AID501180 | Antimicrobial activity against methicillin sensitive Staphylococcus aureus 310 at 30 ug after 18 hrs by agar diffusion method | 2009 | Journal of natural products, Oct, Volume: 72, Issue:10 | Norselic acids A-E, highly oxidized anti-infective steroids that deter mesograzer predation, from the Antarctic sponge Crella sp. |
| AID330984 | Antimicrobial activity against Staphylococcus aureus 29213 | 2007 | Nature, May-03, Volume: 447, Issue:7140 | PTC124 targets genetic disorders caused by nonsense mutations. |
| AID1638886 | Antimicrobial activity against Escherichia coli at 0.5 to 256 ug/ml after 24 hrs by two-fold serial micro dilution method | 2019 | Journal of natural products, 04-26, Volume: 82, Issue:4 | Inducing Secondary Metabolite Production by Co-culture of the Endophytic Fungus Phoma sp. and the Symbiotic Fungus Armillaria sp. |
| AID1176775 | Antimicrobial activity against methicillin-resistant and vancomycin-intermediate Staphylococcus aureus NRS402 after 24 hrs by broth microdilution method | 2015 | Journal of natural products, Jan-23, Volume: 78, Issue:1 | Structure and antimicrobial activity of phloroglucinol derivatives from Achyrocline satureioides. |
| AID163056 | Minimum inhibitory concentration was measured against Proteus rettgeri A 21615 | 1980 | Journal of medicinal chemistry, Jan, Volume: 23, Issue:1 | Aminoglycoside antibiotics. 3. Epimino derivatives of neamine, ribostamycin, and kanamycin B. |
| AID1710559 | Antiproliferative activity against human MCF7 cells assessed as reduction in Ki67 expression at 5 uM incubated for 48 hrs by fluorescence microscopy | 2018 | MedChemComm, Jul-01, Volume: 9, Issue:7 | Targeting miRNA by tunable small molecule binders: peptidic aminosugar mediated interference in miR-21 biogenesis reverts epithelial to mesenchymal transition. |
| AID326538 | Antimicrobial activity against Mycobacterium abscessus R39 isolate after 3 to 5 days by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | In Vitro activities of isepamicin, other aminoglycosides, and capreomycin against clinical isolates of rapidly growing mycobacteria in Taiwan. |
| AID1413334 | Antifungal activity against Candida albicans 94-2181 | 2018 | MedChemComm, Jun-01, Volume: 9, Issue:6 | Antifungal amphiphilic kanamycins: new life for an old drug. |
| AID1624155 | Antitubercular activity against multidrug-resistant Mycobacterium tuberculosis isolate 7 after 7 days | 2019 | European journal of medicinal chemistry, Feb-15, Volume: 164 | Synthesis and evaluation of α-aminoacyl amides as antitubercular agents effective on drug resistant tuberculosis. |
| AID1478522 | Antibacterial activity against kanamycin-resistant Escherichia coli AG100A by double microdilution method | 2017 | Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11 | Covalently linked kanamycin - Ciprofloxacin hybrid antibiotics as a tool to fight bacterial resistance. |
| AID556752 | Bactericidal activity against sodA gene-deficient Escherichia coli K-12 3144 after 18 hrs | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Contribution of oxidative damage to antimicrobial lethality. |
| AID584325 | Antibacterial activity against wild type Escherichia coli BW25113 | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics. |
| AID1113099 | Antibacterial activity against Bacillus subtilis after 24 hr by microdilution method | 2013 | Journal of agricultural and food chemistry, Mar-27, Volume: 61, Issue:12 | Isolation and characterization of new p-Terphenyls with antifungal, antibacterial, and antioxidant activities from halophilic actinomycete Nocardiopsis gilva YIM 90087. |
| AID424590 | Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH346 (SCV-18) harboring -1 frameshift mutation at nucleotide 238 in rplF gene after 18 to 24 hrs by Etest strip assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID1493078 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis 12 by dilution susceptibility test | 2017 | Journal of natural products, 11-22, Volume: 80, Issue:11 | Antibacterial 3,6-Disubstituted 4-Hydroxy-5,6-dihydro-2H-pyran-2-ones from Serratia plymuthica MF371-2. |
| AID534342 | Antimicrobial activity against Burkholderia pseudomallei Bp58 harboring deleted bpeR::FRT gene after 24 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | The BpeAB-OprB efflux pump of Burkholderia pseudomallei 1026b does not play a role in quorum sensing, virulence factor production, or extrusion of aminoglycosides but is a broad-spectrum drug efflux system. |
| AID1167354 | Antibacterial activity against Escherichia coli D21 tolC deletion mutant after 18 to 24 hrs by two-fold broth microdilution method | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21 | Design, synthesis, and antibacterial properties of dual-ligand inhibitors of acetyl-CoA carboxylase. |
| AID1182147 | Ratio of MIC99 for Mycobacterium smegmatis to ratio of MIC99 for Mycobacterium smegmatis in presence of chlorpromazine | 2014 | Bioorganic & medicinal chemistry, Aug-15, Volume: 22, Issue:16 | Pharmacologically active metabolites, combination screening and target identification-driven drug repositioning in antituberculosis drug discovery. |
| AID729398 | Antimicrobial activity against wild type Escherichia coli K1 after overnight incubation by checkerboard assay | 2013 | Journal of medicinal chemistry, Mar-14, Volume: 56, Issue:5 | Vectorization efforts to increase Gram-negative intracellular drug concentration: a case study on HldE-K inhibitors. |
| AID1079945 | Animal toxicity known. [column 'TOXIC' in source] | |||
| AID1467593 | Antibacterial activity against Escherichia coli NBRC 102203 after 12 hrs by MTT assay | 2017 | Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14 | New merosesquiterpenes from a Vietnamese marine sponge of Spongia sp. and their biological activities. |
| AID1287516 | Antibacterial activity against Bacillus subtilis NCIM 2079 after 12 hrs | 2016 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 26, Issue:7 | Synthesis, biological evaluation and molecular docking study of some novel indole and pyridine based 1,3,4-oxadiazole derivatives as potential antitubercular agents. |
| AID532029 | Antimicrobial activity against Escherichia coli TOP10F' transformant harboring beta-lactamase CTX-M-78 by disk diffusion method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Novel chromosome-encoded CTX-M-78 beta-lactamase from a Kluyvera georgiana clinical isolate as a putative origin of CTX-M-25 subgroup. |
| AID69506 | Minimum inhibitory concentration was measured against Escherichia coli A 20507 | 1980 | Journal of medicinal chemistry, Jan, Volume: 23, Issue:1 | Aminoglycoside antibiotics. 3. Epimino derivatives of neamine, ribostamycin, and kanamycin B. |
| AID740234 | Antibacterial activity against Bacillus subtilis ATCC 6538 assessed as growth inhibition after 24 hrs by MTT assay | 2013 | Bioorganic & medicinal chemistry, Apr-15, Volume: 21, Issue:8 | Novel 1,3,4-oxadiazole thioether derivatives targeting thymidylate synthase as dual anticancer/antimicrobial agents. |
| AID556563 | Antimicrobial activity against sodB gene-deficient Escherichia coli K-12 3145 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Contribution of oxidative damage to antimicrobial lethality. |
| AID1105383 | Antibacterial activity against Erwinia chrysanthemi ITCC B-40 assessed as as growth inhibition at 25 ug/disk after 24 hr by disk diffusion method | 2013 | European journal of medicinal chemistry, Jan, Volume: 59 | Microwave synthesis, characterization and bio-efficacy evaluation of novel chalcone based 6-carbethoxy-2-cyclohexen-1-one and 2H-indazol-3-ol derivatives. |
| AID534340 | Antimicrobial activity against Burkholderia pseudomallei Bp50 harboring deleted (amrRAB-oprA)::FRT gene after 24 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | The BpeAB-OprB efflux pump of Burkholderia pseudomallei 1026b does not play a role in quorum sensing, virulence factor production, or extrusion of aminoglycosides but is a broad-spectrum drug efflux system. |
| AID1287417 | Ratio of MIC for Mycobacterium bovis BCG overexpressing InhA to MIC for Mycobacterium bovis BCG | 2016 | European journal of medicinal chemistry, Apr-13, Volume: 112 | New direct inhibitors of InhA with antimycobacterial activity based on a tetrahydropyran scaffold. |
| AID283531 | Antibacterial activity against Pseudomonas aeruginosa FE49 with inactivated galU gene by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides. |
| AID1167357 | Antibacterial activity against wild type Staphylococcus aureus ATCC 29213 after 18 to 24 hrs by two-fold broth microdilution method | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21 | Design, synthesis, and antibacterial properties of dual-ligand inhibitors of acetyl-CoA carboxylase. |
| AID563507 | Antimicrobial activity against cetylpyridinium chloride-sensitive Serratia marcescens 71 harboring plasmid STV29 expressing hasF gene by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Mutational upregulation of a resistance-nodulation-cell division-type multidrug efflux pump, SdeAB, upon exposure to a biocide, cetylpyridinium chloride, and antibiotic resistance in Serratia marcescens. |
| AID278267 | Antimicrobial activity against Salmonella enterica serovar Typhimurium CHS18 tolC::Kan with GyrA S38F mutation | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials. |
| AID544028 | Antimicrobial activity against Acinetobacter lwoffii isolate C141 harboring sul1 to sul3 genes assessed as antibiotic resistance breakpoint by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Prevalence of sulfonamide resistance genes in bacterial isolates from manured agricultural soils and pig slurry in the United Kingdom. |
| AID1167353 | Antibacterial activity against Escherichia coli D21 IpxC101 deletion mutant after 18 to 24 hrs by two-fold broth microdilution method | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21 | Design, synthesis, and antibacterial properties of dual-ligand inhibitors of acetyl-CoA carboxylase. |
| AID1193567 | Antibacterial activity against Proteus mirabilis ATCC 14153 at 100 ug after 24 hrs | 2015 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 25, Issue:7 | Synthesis of 3-azabicyclo[3.2.2]nonanes and their antiprotozoal activities. |
| AID1455936 | Antibacterial activity against Micrococcus luteus after 48 hrs by broth micro-dilution method | 2017 | Journal of natural products, 02-24, Volume: 80, Issue:2 | Nabscessins A and B, Aminocyclitol Derivatives from Nocardia abscessus IFM 10029 |
| AID1585653 | Antibacterial activity against methicillin-resistant Staphylococcus epidermidis after overnight incubation by micro broth dilution analysis | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Discovery of novel arylethenesulfonyl fluorides as potential candidates against methicillin-resistant of Staphylococcus aureus (MRSA) for overcoming multidrug resistance of bacterial infections. |
| AID278239 | Antimicrobial activity against Salmonella enterica serovar Typhimurium S21-2 tolC::Kan with GyrA S83F, ParC S80I mutation | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials. |
| AID278268 | Antimicrobial activity against Salmonella enterica serovar Typhimurium CHS38 with GyrA D87G mutation | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials. |
| AID563501 | Antimicrobial activity against cetylpyridinium chloride-resistant Serratia marcescens 01 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Mutational upregulation of a resistance-nodulation-cell division-type multidrug efflux pump, SdeAB, upon exposure to a biocide, cetylpyridinium chloride, and antibiotic resistance in Serratia marcescens. |
| AID1616527 | Antibacterial activity against Pseudomonas aeruginosa ATCC 15442 assessed as growth inhibition at 0.125 mg/ml by microbroth dilution method relative to control | 2019 | Journal of natural products, 10-25, Volume: 82, Issue:10 | Polyketides from Marine-Derived |
| AID1905606 | Induction of drug resistance in Staphylococcus aureus ATCC 25923 assessed as fold increase in MIC after 5 passages by CLSI protocol based broth microdilution method | 2022 | Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7 | Novel β-Hairpin Antimicrobial Peptides Containing the β-Turn Sequence of -RRRF- Having High Cell Selectivity and Low Incidence of Drug Resistance. |
| AID278252 | Antimicrobial activity against Salmonella enterica serovar Typhimurium CS3 with GyrA S83F, D87N, ParC S80I mutation | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials. |
| AID424826 | Antibacterial activity against kanamycin-resistant and fusidic acid-susceptible Staphylococcus aureus AH298 harboring Gly664Val mutation in fusA gene after 18 to 24 hrs by Etest strip assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID245396 | Minimum inhibitory concentration against Mycobacterium tuberculosis H37Rv pFPCA1 in green fluorescent protein microplate assay | 2005 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 15, Issue:18 | Identification of heteroarylenamines as a new class of antituberculosis lead molecules. |
| AID424342 | Antibacterial activity against fusidic acid-resistant Staphylococcus aureus AH187 harboring His457Tyr mutation in fusA gene after 18 to 24 hrs by Etest strip assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID1890848 | Selectivity index, ratio of MIC90 for antimycobacterial activity against Mycobacterium smegmatis mc2 155 harbouring pMyC::PDFMtb overexpression mutant to MIC90 for antimycobacterial activity against wild type Mycobacterium smegmatis mc2 155 | 2022 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 64 | Design, synthesis and antibacterial activity against pathogenic mycobacteria of conjugated hydroxamic acids, hydrazides and O-alkyl/O-acyl protected hydroxamic derivatives. |
| AID207041 | Antibacterial activity expressed as MIC value was determined on Staphylococcus aureus A-22210 organism | 1986 | Journal of medicinal chemistry, May, Volume: 29, Issue:5 | Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin. |
| AID1182142 | Antitubercular activity against Mycobacterium smegmatis by checkerboard assay in presence of nor-chlorpromazine | 2014 | Bioorganic & medicinal chemistry, Aug-15, Volume: 22, Issue:16 | Pharmacologically active metabolites, combination screening and target identification-driven drug repositioning in antituberculosis drug discovery. |
| AID1191413 | Antimicrobial activity against Staphylococcus aureus PCM 2602 (ATCC 6538) after 16 to 20 hrs by broth micro-dilution method | 2015 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 25, Issue:3 | In vitro studies of antimicrobial activity of Gly-His-Lys conjugates as potential and promising candidates for therapeutics in skin and tissue infections. |
| AID524394 | Antibacterial activity against Escherichia coli NKE1355 harboring deletion mutation in acrB protein and plasmid expressing BAD gene in presence of increasing concentration of arabinose | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Effect of NlpE overproduction on multidrug resistance in Escherichia coli. |
| AID1478525 | Antibacterial activity against aminoglycosides-susceptible Bacillus subtilis by double microdilution method | 2017 | Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11 | Covalently linked kanamycin - Ciprofloxacin hybrid antibiotics as a tool to fight bacterial resistance. |
| AID1226731 | Antimicrobial activity against Staphylococcus aureus incubated at 37 degC overnight for 18 hrs | 2015 | ACS medicinal chemistry letters, Apr-09, Volume: 6, Issue:4 | Membrane-Targeting DCAP Analogues with Broad-Spectrum Antibiotic Activity against Pathogenic Bacteria. |
| AID1585671 | Antibacterial activity against methicillin-resistant Staphylococcus epidermidis assessed as zone of inhibition at 30 ug/mL after 24 hrs by agar disc diffusion method | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Discovery of novel arylethenesulfonyl fluorides as potential candidates against methicillin-resistant of Staphylococcus aureus (MRSA) for overcoming multidrug resistance of bacterial infections. |
| AID1287400 | Antimicrobial activity against Staphylococcus aureus after 24 hrs by serial two-fold microbroth dilution method | 2016 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 26, Issue:6 | One-pot synthesis and antimicrobial evaluation of novel 3-cyanopyridine derivatives of (-)-β-pinene. |
| AID1740924 | Selectivity ratio of IC50 for inhibition of human Cx43 to IC50 for inhibition of human Cx26 | 2020 | European journal of medicinal chemistry, Oct-01, Volume: 203 | Amphiphilic aminoglycosides with increased selectivity for inhibition of connexin 43 (Cx43) hemichannels. |
| AID1334267 | Antibacterial activity against Pseudomonas aeruginosa | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2 | New bithiazolyl hydrazones: Novel synthesis, characterization and antitubercular evaluation. |
| AID1617945 | Antibacterial activity against Salmonella enterica ATCC 10708 after 16 to 48 hrs | 2019 | Journal of natural products, 12-27, Volume: 82, Issue:12 | Structure Determination, Functional Characterization, and Biosynthetic Implications of Nybomycin Metabolites from a Mining Reclamation Site-Associated |
| AID520868 | Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus saprophyticus isolate TSU28 isolated from genitourinary tracts of acute cystitis patient after 24 hrs at 35 degC by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Methicillin-resistant Staphylococcus saprophyticus isolates carrying staphylococcal cassette chromosome mec have emerged in urogenital tract infections. |
| AID1629132 | Antimicrobial activity against aminoglycoside-resistant Klebsiella pneumoniae ATCC BAA-2470 measured after 24 hrs by double-dilution method | 2016 | Journal of medicinal chemistry, 09-08, Volume: 59, Issue:17 | Effects of 5-O-Ribosylation of Aminoglycosides on Antimicrobial Activity and Selective Perturbation of Bacterial Translation. |
| AID565419 | Antimicrobial activity against Salmonella enterica serotype Virchow isolate AM23818 expressing rmtC rRNA methyltransferase gene by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | Identification of the aminoglycoside resistance determinants armA and rmtC among non-Typhi Salmonella isolates from humans in the United States. |
| AID584123 | Antimicrobial activity against Staphylococcus aureus RN4220 carrying pAFS11-apmA, erm(B), tet(L), dfrK, aadD resistance genes by CLSI M31-A3 method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Novel apramycin resistance gene apmA in bovine and porcine methicillin-resistant Staphylococcus aureus ST398 isolates. |
| AID532988 | Antibacterial activity against Klebsiella aerogenes NCIM 2281 | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | N-acetylcysteine-mediated modulation of bacterial antibiotic susceptibility. |
| AID1105402 | Antibacterial activity against Bacillus thuringiensis MTCC 6941 assessed as growth inhibition at 25 ug/disk after 24 hr by disk diffusion method | 2013 | European journal of medicinal chemistry, Jan, Volume: 59 | Microwave synthesis, characterization and bio-efficacy evaluation of novel chalcone based 6-carbethoxy-2-cyclohexen-1-one and 2H-indazol-3-ol derivatives. |
| AID278525 | Antimicrobial activity against Bifidobacterium breve ATCC 15700 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID1079948 | Times to onset, minimal and maximal, observed in the indexed observations. [column 'DELAI' in source] | |||
| AID1132231 | Antibacterial activity against kanamycin and gentamicin-resistant Pseudomonas aeruginosa 3033 assessed as growth inhibition by agar dilution method | 1978 | Journal of medicinal chemistry, Feb, Volume: 21, Issue:2 | Chemical modification of 1,4-diamino-1,4-dideoxy-3-O-(4-deoxy-4-propionamido-alpha-D-glucopyranosyl)-D-glucitol. |
| AID299665 | Antibacterial activity against Bacillus subtilis ATCC 6633 by broth microdilution method | 2007 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 17, Issue:15 | Synthesis and evaluation of amphiphilic cationic quinine-derived for antibacterial activity against methicillin-resistant Staphylococcus aureus. |
| AID1299579 | Antibacterial activity against Staphylococcus aureus RN4220 ATCC 35556 incubated overnight by microbroth dilution method | 2016 | Journal of medicinal chemistry, Apr-14, Volume: 59, Issue:7 | Antibacterial Diamines Targeting Bacterial Membranes. |
| AID1293900 | Antibacterial activity against Staphylococcus aureus after 18 hrs by broth dilution method | 2016 | Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9 | Novel tetrazoloquinoline-rhodanine conjugates: Highly efficient synthesis and biological evaluation. |
| AID771508 | Antibacterial activity against Staphylococcus aureus RN4220 by dilution technique | 2013 | European journal of medicinal chemistry, Oct, Volume: 68 | Synthesis and biological evaluation of novel ocotillol-type triterpenoid derivatives as antibacterial agents. |
| AID290150 | Antifungal activity against Trichophyton rubrum after 48 hrs by MTT colorimetric method | 2007 | European journal of medicinal chemistry, Apr, Volume: 42, Issue:4 | Synthesis and antimicrobial activities of Schiff bases derived from 5-chloro-salicylaldehyde. |
| AID1265799 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 by microdilution method | 2015 | Journal of medicinal chemistry, Dec-10, Volume: 58, Issue:23 | Synthesis and Bioactivities of Kanamycin B-Derived Cationic Amphiphiles. |
| AID164256 | Antibacterial activity expressed as MIC value was determined on Pseudomonas aeruginosa A-21508 organism | 1986 | Journal of medicinal chemistry, May, Volume: 29, Issue:5 | Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin. |
| AID1738319 | Antibacterial activity against Staphylococcus aureus Newman strain assessed as reduction in bacterial growth incubated for 16 to 18 hrs by two fold serial dilution method | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Capsaicin derivatives with nitrothiophene substituents: Design, synthesis and antibacterial activity against multidrug-resistant S. aureus. |
| AID1566495 | Inhibition of biotinylated pre-let-7d (unknown origin) maturation at 1 mM preincubated for 15 mins followed by Pre-let-7d addition and measured after 5 hrs by cat-ELCCA | 2019 | ACS medicinal chemistry letters, May-09, Volume: 10, Issue:5 | Tetracyclines as Inhibitors of Pre-microRNA Maturation: A Disconnection between RNA Binding and Inhibition. |
| AID1334266 | Antibacterial activity against Escherichia coli | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2 | New bithiazolyl hydrazones: Novel synthesis, characterization and antitubercular evaluation. |
| AID560599 | Antimicrobial activity against Escherichia coli JM109 transformant harboring pSTV28 plasmid expressing aac(6')-Iaf wild type gene by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | AAC(6')-Iaf, a novel aminoglycoside 6'-N-acetyltransferase from multidrug-resistant Pseudomonas aeruginosa clinical isolates. |
| AID492160 | Antimicrobial activity against Escherichia coli ATCC 8739 at 100 ug/well after 24 hrs at 37 degC by agar diffusion assay | 2010 | Journal of natural products, Jul-23, Volume: 73, Issue:7 | Cellular localization of clathridimine, an antimicrobial 2-aminoimidazole alkaloid produced by the Mediterranean calcareous sponge Clathrina clathrus. |
| AID523398 | Antimicrobial activity against amikacin-susceptible Nocardia farcinica IFM 10152 harboring 16s rRNA A1408G mutant after 5 days by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Homozygous triplicate mutations in three 16S rRNA genes responsible for high-level aminoglycoside resistance in Nocardia farcinica clinical isolates from a Canada-wide bovine mastitis epizootic. |
| AID1436940 | Antibacterial activity against Pseudomonas fluorescens ATCC 13525 after 8 hrs | 2017 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 27, Issue:4 | Quinolidene based monocarbonyl curcumin analogues as promising antimycobacterial agents: Synthesis and molecular docking study. |
| AID580177 | Antimicrobial activity against Bacillus subtilis ATCC 6633 after 24 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry, Mar-01, Volume: 19, Issue:5 | Synthesis, structure, molecular docking, and structure-activity relationship analysis of enamines: 3-aryl-4-alkylaminofuran-2(5H)-ones as potential antibacterials. |
| AID145297 | Tested for antibacterial activity against Mycobacterium tuberculosis H37Rv streptomycin resistant strain | 1985 | Journal of medicinal chemistry, Dec, Volume: 28, Issue:12 | Synthesis and antibacterial activity of 2,2'-dithiobis(benzamide) derivatives against Mycobacterium species. |
| AID1436942 | Antibacterial activity against Bacillus subtilis ATCC 23857 after 12 hrs | 2017 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 27, Issue:4 | Quinolidene based monocarbonyl curcumin analogues as promising antimycobacterial agents: Synthesis and molecular docking study. |
| AID278563 | Antimicrobial activity against 90 mins hydrogen peroxide-stressed Bifidobacterium longum ATCC 15707 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID1905614 | Antimicrobial activity against kanamycin-resistant Staphylococcus aureus ATCC 25923 | 2022 | Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7 | Novel β-Hairpin Antimicrobial Peptides Containing the β-Turn Sequence of -RRRF- Having High Cell Selectivity and Low Incidence of Drug Resistance. |
| AID524387 | Antibacterial activity against Escherichia coli NKE1365 harboring deletion mutation in acrB and mdtABC protein | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Effect of NlpE overproduction on multidrug resistance in Escherichia coli. |
| AID424588 | Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH348 (SCV-20) harboring TGA stop codon at nucleotide 244 in rplF gene after 18 to 24 hrs by Etest strip assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID574590 | Antimycobacterial activity against extensively drug-resistant Mycobacterium tuberculosis isolate 761 obtained from pus of patient at 4 ug/ml by Bactec MGIT960 modified proportion method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Emergence and molecular characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates from the Delhi Region in India. |
| AID1202742 | Antimicrobial activity against Bacillus subtilis assessed as reduction in bacterial growth incubated for 48 hrs by microbroth dilution method | 2015 | Journal of natural products, Feb-27, Volume: 78, Issue:2 | Prenylated benzophenones from Triadenum japonicum. |
| AID1385094 | Inhibition of recombinant human Cx26 expressed in Escherichia coli LB2003 assessed as reduction in cell growth measured after 18 hrs | 2018 | ACS medicinal chemistry letters, Jul-12, Volume: 9, Issue:7 | Inhibition of Connexin Hemichannels by New Amphiphilic Aminoglycosides without Antibiotic Activity. |
| AID278228 | Antimicrobial activity against Salmonella enterica serovar Typhimurium S21 | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials. |
| AID278265 | Antimicrobial activity against Salmonella enterica serovar Typhimurium CHS18 gyrA+ with GyrA S38F mutation | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials. |
| AID283537 | Antibacterial activity against Pseudomonas aeruginosa FE57U with inactivated rplY and galU genes by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides. |
| AID1510724 | Antibacterial activity against Staphylococcus aureus | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Nitroimidazole-containing compounds and their antibacterial and antitubercular activities. |
| AID740235 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 assessed as growth inhibition after 24 hrs by MTT assay | 2013 | Bioorganic & medicinal chemistry, Apr-15, Volume: 21, Issue:8 | Novel 1,3,4-oxadiazole thioether derivatives targeting thymidylate synthase as dual anticancer/antimicrobial agents. |
| AID293135 | Antimicrobial activity against Bacillus subtilis | 2007 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 17, Issue:3 | Design, synthesis, and evaluation of efflux substrate-metal chelator conjugates as potential antimicrobial agents. |
| AID1478533 | Antibacterial activity against Escherichia coli XL1 blue by double microdilution method | 2017 | Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11 | Covalently linked kanamycin - Ciprofloxacin hybrid antibiotics as a tool to fight bacterial resistance. |
| AID1169514 | Antibacterial activity against Pseudomonas aeruginosa after 24 hrs by MTT method | 2014 | Bioorganic & medicinal chemistry letters, Sep-28 | Design, synthesis and biological evaluation of metronidazole-thiazole derivatives as antibacterial inhibitors. |
| AID1169514 | Antibacterial activity against Pseudomonas aeruginosa after 24 hrs by MTT method | 2014 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22 | Design, synthesis and biological evaluation of metronidazole-thiazole derivatives as antibacterial inhibitors. |
| AID567091 | Drug absorption in human assessed as human intestinal absorption rate | 2011 | European journal of medicinal chemistry, Jan, Volume: 46, Issue:1 | Prediction of drug intestinal absorption by new linear and non-linear QSPR. |
| AID1695862 | Antibacterial activity against Escherichia coli NCIM 2256 incubated for 24 hrs | 2019 | European journal of medicinal chemistry, Apr-15, Volume: 168 | Comprehensive review on the anti-bacterial activity of 1,2,3-triazole hybrids. |
| AID1226730 | Antimicrobial activity against Escherichia coli MG1655 incubated at 37 degC overnight for 18 hrs | 2015 | ACS medicinal chemistry letters, Apr-09, Volume: 6, Issue:4 | Membrane-Targeting DCAP Analogues with Broad-Spectrum Antibiotic Activity against Pathogenic Bacteria. |
| AID584334 | Antibacterial activity against wild type Escherichia coli BW25113 presence of 5 mM of glutathione | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics. |
| AID544288 | Antimicrobial activity against Enterococcus faecalis NKH18 harboring pMG2200-like and pMG2201-like plasmids after 24 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Isolation of VanB-type Enterococcus faecalis strains from nosocomial infections: first report of the isolation and identification of the pheromone-responsive plasmids pMG2200, Encoding VanB-type vancomycin resistance and a Bac41-type bacteriocin, and pMG2 |
| AID293862 | Antibacterial activity against methicillin-resistant Staphylococcus aureus CMAH 0515 after 24 hrs by two fold dilution method | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6 | Synthesis of pseudopeptides based L-tryptophan as a potential antimicrobial agent. |
| AID374113 | Antimicrobial activity against azide-resistant Escherichia coli J53 by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Prevalence and expression of the plasmid-mediated quinolone resistance determinant qnrA1. |
| AID588122 | Ratio of MIC for Streptococcus pyogenes 12RF transconjugant harboring ermB and tetW gene from Streptococcus suis UD to wild type Streptococcus suis UD | 2011 | Antimicrobial agents and chemotherapy, Feb, Volume: 55, Issue:2 | Different genetic elements carrying the tet(W) gene in two human clinical isolates of Streptococcus suis. |
| AID1629126 | Antimicrobial activity against Klebsiella pneumoniae ATCC 13883 measured after 24 hrs by double-dilution method | 2016 | Journal of medicinal chemistry, 09-08, Volume: 59, Issue:17 | Effects of 5-O-Ribosylation of Aminoglycosides on Antimicrobial Activity and Selective Perturbation of Bacterial Translation. |
| AID1565716 | Antifungal activity against Fusarium graminearum B4-5A incubated for 24 to 36 hrs by two fold dilution method | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Scalable and cost-effective tosylation-mediated synthesis of antifungal and fungal diagnostic 6″-Modified amphiphilic kanamycins. |
| AID278257 | Antimicrobial activity against Salmonella enterica serovar Typhimurium CS9 gyrA+ with GyrA S83F, D87N, ParC S80I mutation | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials. |
| AID299667 | Antibacterial activity against Escherichia coli ATCC 25922 by broth microdilution method | 2007 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 17, Issue:15 | Synthesis and evaluation of amphiphilic cationic quinine-derived for antibacterial activity against methicillin-resistant Staphylococcus aureus. |
| AID1056536 | Antibacterial activity against methicillin-resistant Staphylococcus aureus clinical isolate shhs-A1 by broth microdilution method | 2013 | Journal of natural products, Dec-27, Volume: 76, Issue:12 | Cytotoxic and antibacterial marfuraquinocins from the deep South China Sea-derived Streptomyces niveus SCSIO 3406. |
| AID278248 | Antimicrobial activity against Salmonella enterica serovar Typhimurium CS1 with GyrA S83F, D87N, ParC S80I mutation | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials. |
| AID1169515 | Antibacterial activity against Bacillus thuringiensis after 24 hrs by MTT method | 2014 | Bioorganic & medicinal chemistry letters, Sep-28 | Design, synthesis and biological evaluation of metronidazole-thiazole derivatives as antibacterial inhibitors. |
| AID1169515 | Antibacterial activity against Bacillus thuringiensis after 24 hrs by MTT method | 2014 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22 | Design, synthesis and biological evaluation of metronidazole-thiazole derivatives as antibacterial inhibitors. |
| AID544029 | Antimicrobial activity against Bacillus psychrodurans isolate C328 harboring sul1 to sul3 genes assessed as antibiotic resistance breakpoint by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Prevalence of sulfonamide resistance genes in bacterial isolates from manured agricultural soils and pig slurry in the United Kingdom. |
| AID1306203 | Bactericidal activity against Staphylococcus aureus ATCC 25923 after 18 hrs by microbroth dilution assay | 2016 | Bioorganic & medicinal chemistry, 07-15, Volume: 24, Issue:14 | The influence of halogen substituents on the biological properties of sulfur-containing flavonoids. |
| AID556565 | Antimicrobial activity against katG gene-deficient Escherichia coli K-12 3157 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Contribution of oxidative damage to antimicrobial lethality. |
| AID759043 | Antibacterial activity against Pseudomonas aeruginosa assessed as survival after 24 hrs by MTT assay | 2013 | European journal of medicinal chemistry, Jul, Volume: 65 | Potentiating 1-(2-hydroxypropyl)-2-styryl-5-nitroimidazole derivatives against antibacterial agents: design, synthesis and biology analysis. |
| AID1593384 | Growth inhibition of Staphylococcus aureus Newman | 2019 | Journal of medicinal chemistry, 04-11, Volume: 62, Issue:7 | Identification of Novel Coumestan Derivatives as Polyketide Synthase 13 Inhibitors against Mycobacterium tuberculosis. Part II. |
| AID1402051 | Antibacterial activity against Acinetobacter baumannii ATCC 17978 after 18 to 20 hrs by spectrophotometry based microdilution method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Synthesis and antimicrobial activity of amino acid and peptide derivatives of mycophenolic acid. |
| AID585016 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 335913 | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Inhibition of bacterial multidrug resistance by celecoxib, a cyclooxygenase-2 inhibitor. |
| AID560247 | Antibacterial activity against Staphylococcus aureus RN4220 by CLSI method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Novel ABC transporter gene, vga(C), located on a multiresistance plasmid from a porcine methicillin-resistant Staphylococcus aureus ST398 strain. |
| AID521600 | Antibacterial activity against Salmonella enterica serovars virchow isolate 101591 infected in mouse J774A.1 cells at 50 ug/ml after 1hr | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Aminoglycosides affect intracellular Salmonella enterica serovars typhimurium and virchow. |
| AID278567 | Antimicrobial activity against 90 mins hydrogen peroxide-stressed Bifidobacterium thermophilum ATCC 25866 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID563508 | Antimicrobial activity against cetylpyridinium chloride-sensitive Serratia marcescens 79 harboring plasmid STV29 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Mutational upregulation of a resistance-nodulation-cell division-type multidrug efflux pump, SdeAB, upon exposure to a biocide, cetylpyridinium chloride, and antibiotic resistance in Serratia marcescens. |
| AID278264 | Antimicrobial activity against Salmonella enterica serovar Typhimurium CHS18 with GyrA S38F mutation | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials. |
| AID1303893 | Antibacterial activity against multidrug resistant Klebsiella pneumoniae subsp. pneumoniae NCTC 9633 (ATCC 13883) assessed as reduction in bacterial growth incubated for 6 to 8 hrs | 2016 | Bioorganic & medicinal chemistry letters, 07-01, Volume: 26, Issue:13 | GroEL/ES inhibitors as potential antibiotics. |
| AID374111 | Antimicrobial activity against azide-resistant aac(6')-Ib-cr deficient Escherichia coli J53 qnrA1 bearing pHS5 transconjugant from Enterobacter cloacae 641 by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Prevalence and expression of the plasmid-mediated quinolone resistance determinant qnrA1. |
| AID424575 | Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH364 (SCV-36) harboring Asp434Asn mutation in fusA gene after 18 to 24 hrs by Etest strip assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID333430 | Antitubercular activity against Mycobacterium tuberculosis H37Ra ATCC 25177 after 4 days by microtiter plate alamar blue technique | 2004 | Journal of natural products, Oct, Volume: 67, Issue:10 | Antitubercular sesterterpenes from the Thai sponge Brachiaster sp. |
| AID373986 | Antimicrobial activity against azide-resistant aac(6')-Ib-cr expressing Escherichia coli J53 qnrA1 bearing pHS3 transconjugant from Citrobacter freundii 64 by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Prevalence and expression of the plasmid-mediated quinolone resistance determinant qnrA1. |
| AID1359447 | Antibacterial activity against Staphylococcus aureus NCIM 2010 after 12 hrs by serial dilution method | 2018 | European journal of medicinal chemistry, May-25, Volume: 152 | Antibacterial and anti-TB tat-peptidomimetics with improved efficacy and half-life. |
| AID1629129 | Antimicrobial activity against Acinetobacter baumannii ATCC 19606 measured after 24 hrs by double-dilution method | 2016 | Journal of medicinal chemistry, 09-08, Volume: 59, Issue:17 | Effects of 5-O-Ribosylation of Aminoglycosides on Antimicrobial Activity and Selective Perturbation of Bacterial Translation. |
| AID1473739 | Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and GSH measured after 20 mins by membrane vesicle transport assay | 2013 | Toxicological sciences : an official journal of the Society of Toxicology, Nov, Volume: 136, Issue:1 | A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. |
| AID1869566 | Bactericidal activity against Enterococcus faecium DSM 20477 assessed as reduction in colony count and measured after 3 days by agar diffusion assay | 2022 | Journal of natural products, 06-24, Volume: 85, Issue:6 | Triculamin: An Unusual Lasso Peptide with Potent Antimycobacterial Activity. |
| AID1491154 | Antibacterial activity against Staphylococcus aureus ATCC 29213 by CLSI method | 2017 | Journal of natural products, 05-26, Volume: 80, Issue:5 | Antimicrobial Spirotetronate Metabolites from Marine-Derived Micromonospora harpali SCSIO GJ089. |
| AID580178 | Antimicrobial activity against Staphylococcus aureus ATCC 25923 after 24 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry, Mar-01, Volume: 19, Issue:5 | Synthesis, structure, molecular docking, and structure-activity relationship analysis of enamines: 3-aryl-4-alkylaminofuran-2(5H)-ones as potential antibacterials. |
| AID1113100 | Antibacterial activity against Staphylococcus aureus after 24 hr by microdilution method | 2013 | Journal of agricultural and food chemistry, Mar-27, Volume: 61, Issue:12 | Isolation and characterization of new p-Terphenyls with antifungal, antibacterial, and antioxidant activities from halophilic actinomycete Nocardiopsis gilva YIM 90087. |
| AID515080 | Antimycobacterial activity against Mycobacterium tuberculosis H37Ra after 24 hrs by microtiter alamar blue assay | 2010 | European journal of medicinal chemistry, Oct, Volume: 45, Issue:10 | Isoxazole analogs of curcuminoids with highly potent multidrug-resistant antimycobacterial activity. |
| AID1710553 | Displacement of F-neo from premature miRNA21 (unknown origin) by fluorescence assay | 2018 | MedChemComm, Jul-01, Volume: 9, Issue:7 | Targeting miRNA by tunable small molecule binders: peptidic aminosugar mediated interference in miR-21 biogenesis reverts epithelial to mesenchymal transition. |
| AID325447 | Antibacterial activity against Staphylococcus aureus N315 after 14 to 16 hrs by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Polyamine effects on antibiotic susceptibility in bacteria. |
| AID275054 | Antibacterial activity against Escherichia coli W3110 | 2006 | Journal of medicinal chemistry, Dec-14, Volume: 49, Issue:25 | Isoprenoid biosynthesis as a drug target: bisphosphonate inhibition of Escherichia coli K12 growth and synergistic effects of fosmidomycin. |
| AID529456 | Antimicrobial activity against Klebsiella pneumoniae containing PFGE clone A expressing beta-lactamase Oxa-48, TEM-1, SHV-12 and Oxa-9 by Etest | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Spread of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in Istanbul, Turkey. |
| AID50539 | Minimum inhibitory concentration (MIC) was measured against Citrobacter freundii. | 1995 | Journal of medicinal chemistry, Nov-10, Volume: 38, Issue:23 | Synthesis and antimicrobial and toxicological studies of amino acid and peptide derivatives of kanamycin A and netilmicin. |
| AID556757 | Bactericidal activity against katG,katE gene-deficient Escherichia coli K-12 3201 after 18 hrs | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Contribution of oxidative damage to antimicrobial lethality. |
| AID586086 | Antimicrobial activity against verocytotoxin-producing Escherichia coli isolate O157 obtained from animals and food assessed as percentage of resistant isolates by disk diffusion method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Antimicrobial resistance testing of verocytotoxin-producing Escherichia coli and first description of TEM-52 extended-spectrum β-lactamase in serogroup O26. |
| AID424573 | Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH366 (SCV-38) harboring Pro114His mutation in fusA gene after 18 to 24 hrs by Etest strip assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID68017 | Antibacterial activity expressed as MIC value was determined on Enterobacter cloacae A-21136 organism | 1986 | Journal of medicinal chemistry, May, Volume: 29, Issue:5 | Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin. |
| AID1271376 | Antimicrobial activity against Gram-positive Bacillus anthracis str. Sterne after 16 to 24 hrs by micro-dilution method | 2015 | ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11 | Synthesis and Biological Activity of Mono- and Di-N-acylated Aminoglycosides. |
| AID1882862 | Antibacterial activity against Escherichia coli K12 expressing modified luxABCDE genes assessed as reduction in bacterial growth by measuring reduction in bioluminescence at 40 uM incubated for 16 hrs by microplate reader analysis | 2022 | European journal of medicinal chemistry, Jul-05, Volume: 237 | The role of the maleimide ring system on the structure-activity relationship of showdomycin. |
| AID445210 | Antituberculosis activity against Mycobacterium tuberculosis H37Rv by broth dilution method | 2009 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 19, Issue:22 | Synthesis of new sugar derivatives and evaluation of their antibacterial activities against Mycobacterium tuberculosis. |
| AID1474167 | Liver toxicity in human assessed as induction of drug-induced liver injury by measuring verified drug-induced liver injury concern status | 2016 | Drug discovery today, Apr, Volume: 21, Issue:4 | DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. |
| AID537733 | Binding affinity to Candida albicans CaCdr1p expressed in yeast AD1-8u | 2010 | European journal of medicinal chemistry, Nov, Volume: 45, Issue:11 | Analysis of physico-chemical properties of substrates of ABC and MFS multidrug transporters of pathogenic Candida albicans. |
| AID588213 | Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in non-rodents | 2010 | Chemical research in toxicology, Jan, Volume: 23, Issue:1 | Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. |
| AID425073 | Antimicrobial activity against Escherichia coli DH10B expressing pCR2.1 in presence of IPTG | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Complex class 1 integrons with diverse variable regions, including aac(6')-Ib-cr, and a novel allele, qnrB10, associated with ISCR1 in clinical enterobacterial isolates from Argentina. |
| AID69748 | Antibacterial activity expressed as MIC value was determined on Escherichia coli A-20665 organism | 1986 | Journal of medicinal chemistry, May, Volume: 29, Issue:5 | Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin. |
| AID1730999 | Antibacterial activity against Bacillus subtilis168 assessed as inhibition of bacterial growth measured after 18 hrs by two fold serial dilution method | 2021 | European journal of medicinal chemistry, Mar-05, Volume: 213 | Design and synthesis of mycobacterial pks13 inhibitors: Conformationally rigid tetracyclic molecules. |
| AID1079942 | Steatosis, proven histopathologically. Value is number of references indexed. [column 'STEAT' in source] | |||
| AID1585464 | Antibacterial activity against linezolid-resistant Staphylococcus aureus NRS-271 measured after 16 hrs | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Design, synthesis and evaluation of hybrid of tetrahydrocarbazole with 2,4-diaminopyrimidine scaffold as antibacterial agents. |
| AID283558 | Antibacterial activity against Escherichia coli AG102 with marR1 mutation after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Substrate competition studies using whole-cell accumulation assays with the major tripartite multidrug efflux pumps of Escherichia coli. |
| AID544285 | Antimicrobial activity against Enterococcus faecalis NKH15 harboring pMG2200-like and pMG2201-like plasmids after 24 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Isolation of VanB-type Enterococcus faecalis strains from nosocomial infections: first report of the isolation and identification of the pheromone-responsive plasmids pMG2200, Encoding VanB-type vancomycin resistance and a Bac41-type bacteriocin, and pMG2 |
| AID1263041 | Antibacterial activity against Burkholderia thailandensis E264 at 0.5 mM after 24 to 48 hrs by Kirby-Bauer disc diffusion susceptibility test | 2015 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 25, Issue:24 | Synthesis and biological evaluation of pyrazolopyrimidines as potential antibacterial agents. |
| AID1710567 | Antibacterial activity against Staphylococcus aureus ATCC 25923 assessed as reduction in bacterial growth at 64 uM incubated for 15 to 20 hrs by broth microdilution method relative to control | 2018 | MedChemComm, Jul-01, Volume: 9, Issue:7 | Targeting miRNA by tunable small molecule binders: peptidic aminosugar mediated interference in miR-21 biogenesis reverts epithelial to mesenchymal transition. |
| AID404897 | Antibacterial activity against high-level gentamicin resistant Streptococcus pasteurianus SB30 isolate carrying transposon-borne resistance gene [aac(6')Ie-aph(2'')Ia] by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | High-level gentamicin resistance mediated by a Tn4001-like transposon in seven nonclonal hospital isolates of Streptococcus pasteurianus. |
| AID1265796 | Antibacterial activity against Acinetobacter baumannii ATCC 19606 by microdilution method | 2015 | Journal of medicinal chemistry, Dec-10, Volume: 58, Issue:23 | Synthesis and Bioactivities of Kanamycin B-Derived Cationic Amphiphiles. |
| AID486971 | Antibacterial activity against Klebsiella pneumoniae ATCC 27736 after 24 hrs by micro broth dilution method | 2010 | European journal of medicinal chemistry, Jun, Volume: 45, Issue:6 | 'On water' assisted synthesis and biological evaluation of nitrogen and sulfur containing hetero-1,4-naphthoquinones as potent antifungal and antibacterial agents. |
| AID1287977 | Antibacterial activity against Escherichia coli after 18 hrs by broth dilution method | 2016 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 26, Issue:7 | Facile synthesis of 1,3-thiazolidin-4-ones as antitubercular agents. |
| AID424569 | Antibacterial activity against stationary-phase rifampin-resistant Staphylococcus aureus 8325-4 culture assessed as number of viable colonies at 8 ug/ ml after 48 hrs | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID1905566 | Antimicrobial activity against Escherichia coli ATCC 25922 assessed as reduction of bacterial growth incubated for 18 hrs by CLSI protocol based broth microdilution method | 2022 | Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7 | Novel β-Hairpin Antimicrobial Peptides Containing the β-Turn Sequence of -RRRF- Having High Cell Selectivity and Low Incidence of Drug Resistance. |
| AID244911 | In-vitro minimum inhibitory concentration against the growth of Pseudomonas aeruginosa | 2005 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 15, Issue:13 | Synthesis of (1,4)-naphthoquinono-[3,2-c]-1H-pyrazoles and their (1,4)-naphthohydroquinone derivatives as antifungal, antibacterial, and anticancer agents. |
| AID1426254 | Antibacterial activity against Klebsiella pneumoniae ATCC 13883 | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | Synthesis and bioactivity investigation of quinone-based dimeric cationic triazolium amphiphiles selective against resistant fungal and bacterial pathogens. |
| AID1182151 | Ratio of MIC99 for Mycobacterium smegmatis to ratio of MIC99 for Mycobacterium smegmatis in presence of 7-hydroxy chlorpromazine | 2014 | Bioorganic & medicinal chemistry, Aug-15, Volume: 22, Issue:16 | Pharmacologically active metabolites, combination screening and target identification-driven drug repositioning in antituberculosis drug discovery. |
| AID387745 | Displacement of thiazole orange from RNA A by fluorescent intercalator displacement assay | 2008 | Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19 | Screening helix-threading peptides for RNA binding using a thiazole orange displacement assay. |
| AID283545 | Antibacterial activity against Pseudomonas aeruginosa FE57GUZ with inactivated rplY, nuoG, galU and mexZ genes by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides. |
| AID556758 | Bactericidal activity against katE gene-deficient Escherichia coli K-12 3202 after 18 hrs | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Contribution of oxidative damage to antimicrobial lethality. |
| AID1491152 | Antibacterial activity against Bacillus thuringiensis BT01 by CLSI method | 2017 | Journal of natural products, 05-26, Volume: 80, Issue:5 | Antimicrobial Spirotetronate Metabolites from Marine-Derived Micromonospora harpali SCSIO GJ089. |
| AID424607 | Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH390 (SCV-62) harboring +1 frameshift mutation at nucleotide 84 in rplF gene after 18 to 24 hrs by Etest strip assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID293871 | Antibacterial activity against Enterobacter aerogenes CMCC(B) 45103 after 24 hrs by two fold dilution method | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6 | Synthesis of pseudopeptides based L-tryptophan as a potential antimicrobial agent. |
| AID69754 | Antibacterial activity expressed as MIC value was determined on Escherichia coli A-21218 organism | 1986 | Journal of medicinal chemistry, May, Volume: 29, Issue:5 | Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin. |
| AID1293899 | Antibacterial activity against Pseudomonas fluorescens after 18 hrs by broth dilution method | 2016 | Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9 | Novel tetrazoloquinoline-rhodanine conjugates: Highly efficient synthesis and biological evaluation. |
| AID604259 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 24 hrs by MTT colorimetric method | 2011 | Bioorganic & medicinal chemistry, Jul-01, Volume: 19, Issue:13 | 4-alkoxy-3-arylfuran-2(5H)-ones as inhibitors of tyrosyl-tRNA synthetase: synthesis, molecular docking and antibacterial evaluation. |
| AID1478521 | Antibacterial activity against kanamycin-resistant Escherichia coli AG100B by double microdilution method | 2017 | Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11 | Covalently linked kanamycin - Ciprofloxacin hybrid antibiotics as a tool to fight bacterial resistance. |
| AID1132238 | Antibacterial activity against drug-sensitive Erwinia 1159 assessed as growth inhibition by agar dilution method | 1978 | Journal of medicinal chemistry, Feb, Volume: 21, Issue:2 | Chemical modification of 1,4-diamino-1,4-dideoxy-3-O-(4-deoxy-4-propionamido-alpha-D-glucopyranosyl)-D-glucitol. |
| AID278244 | Antimicrobial activity against Salmonella enterica serovar Typhimurium S21-4 with GyrA S83F, ParC S80I mutation | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials. |
| AID420210 | Antimicrobial activity against Mycobacterium smegmatis UFPEDA 71 at 30 ug/disk after 24 hrs by disk diffusion method | 2009 | European journal of medicinal chemistry, May, Volume: 44, Issue:5 | Synthesis, antimicrobial and cytotoxic activities of some 5-arylidene-4-thioxo-thiazolidine-2-ones. |
| AID1765574 | Antibacterial activity against Bacillus subtilis ATCC 23857 incubated for 18 hrs by CLSI based broth dilution method | 2021 | Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15 | Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice. |
| AID1585654 | Antibacterial activity against methicillin-resistant Staphylococcus haemolyticus after overnight incubation by micro broth dilution analysis | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Discovery of novel arylethenesulfonyl fluorides as potential candidates against methicillin-resistant of Staphylococcus aureus (MRSA) for overcoming multidrug resistance of bacterial infections. |
| AID424602 | Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH351 (SCV-23) harboring -4 frameshift mutation at nucleotide 45-48 in rplF gene after 18 to 24 hrs by Etest strip assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID1250524 | Antibacterial activity against Escherichia coli ATCC 35218 after 24 hr by MTT assay | 2015 | European journal of medicinal chemistry, Sep-18, Volume: 102 | Synthesis and evaluation of new tyrosyl-tRNA synthetase inhibitors as antibacterial agents based on a N2-(arylacetyl)glycinanilide scaffold. |
| AID532983 | Antibacterial activity against Escherichia coli W3110 | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | N-acetylcysteine-mediated modulation of bacterial antibiotic susceptibility. |
| AID1194691 | Antibacterial activity against Staphylococcus aureus ATCC 25923 assessed as inhibition of microbial growth at 0.064 ug/ml to 125 ug/ml incubated at 37 degC for 20 hrs | 2015 | Bioorganic & medicinal chemistry letters, May-01, Volume: 25, Issue:9 | Three new fusidic acid derivatives and their antibacterial activity. |
| AID145296 | Tested for antibacterial activity against Mycobacterium tuberculosis H37Rv kanamycin resistant strain | 1985 | Journal of medicinal chemistry, Dec, Volume: 28, Issue:12 | Synthesis and antibacterial activity of 2,2'-dithiobis(benzamide) derivatives against Mycobacterium species. |
| AID424345 | Antibacterial activity against fusidic acid-resistant Staphylococcus aureus AH188 harboring Gly664Ser mutation in fusA gene after 18 to 24 hrs by Etest strip assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID1869571 | Antibacterial activity against Acinetobacter baumannii DSM 300007 assessed as reduction in bacterial growth measured after 3 days by broth microdilution method | 2022 | Journal of natural products, 06-24, Volume: 85, Issue:6 | Triculamin: An Unusual Lasso Peptide with Potent Antimycobacterial Activity. |
| AID556589 | Bactericidal activity against Escherichia coli K-12 BW25113 after 18 hrs | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Contribution of oxidative damage to antimicrobial lethality. |
| AID1176779 | Antimicrobial activity against Candida albicans ATCC 1023 after 24 hrs by broth microdilution method | 2015 | Journal of natural products, Jan-23, Volume: 78, Issue:1 | Structure and antimicrobial activity of phloroglucinol derivatives from Achyrocline satureioides. |
| AID1426249 | Antibacterial activity against Staphylococcus aureus ATCC 25923 | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | Synthesis and bioactivity investigation of quinone-based dimeric cationic triazolium amphiphiles selective against resistant fungal and bacterial pathogens. |
| AID69751 | Antibacterial activity expressed as MIC value was determined on Escherichia coli A-20732 organism | 1986 | Journal of medicinal chemistry, May, Volume: 29, Issue:5 | Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin. |
| AID326535 | Antimicrobial activity against Mycobacterium fortuitum after 3 to 5 days by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | In Vitro activities of isepamicin, other aminoglycosides, and capreomycin against clinical isolates of rapidly growing mycobacteria in Taiwan. |
| AID1887296 | Antibacterial activity against Escherichia coli ATCC 25922 assessed as inhibition of bacterial growth incubated for 24 hrs by optical density based analysis | 2022 | Journal of natural products, 09-23, Volume: 85, Issue:9 | Total Syntheses and Antibacterial Evaluations of Neocyclomorusin and Related Flavones. |
| AID1359448 | Antibacterial activity against Staphylococcus epidermidis NCIM 5270 after 12 hrs by serial dilution method | 2018 | European journal of medicinal chemistry, May-25, Volume: 152 | Antibacterial and anti-TB tat-peptidomimetics with improved efficacy and half-life. |
| AID697853 | Inhibition of horse BChE at 2 mg/ml by Ellman's method | 2012 | Bioorganic & medicinal chemistry, Nov-15, Volume: 20, Issue:22 | Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine. |
| AID1738321 | Antibacterial activity against multidrug-resistant Staphylococcus aureus NRS70 assessed as reduction in bacterial growth incubated for 16 to 18 hrs by two fold serial dilution method | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Capsaicin derivatives with nitrothiophene substituents: Design, synthesis and antibacterial activity against multidrug-resistant S. aureus. |
| AID369075 | Antimicrobial activity against Staphylococcus aureus ATCC 6538 after 24 hrs by MTT assay | 2009 | Bioorganic & medicinal chemistry, Feb-01, Volume: 17, Issue:3 | Synthesis, structure and antibacterial activity of new 2-(1-(2-(substituted-phenyl)-5-methyloxazol-4-yl)-3-(2-substitued-phenyl)-4,5-dihydro-1H-pyrazol-5-yl)-7-substitued-1,2,3,4-tetrahydroisoquinoline derivatives. |
| AID1413324 | Antifungal activity against Cryptococcus neoformans H99 | 2018 | MedChemComm, Jun-01, Volume: 9, Issue:6 | Antifungal amphiphilic kanamycins: new life for an old drug. |
| AID1868100 | Antibacterial activity against Bacillus subtilis ATCC 6633 assessed as inhibition of visible bacterial growth incubated for 18 hrs by CLSI protocol based assay | 2022 | Journal of natural products, 05-27, Volume: 85, Issue:5 | Enceleamycins A-C, Furo-Naphthoquinones from |
| AID1347678 | Growth inhibition of wild-type Yersinia pseudotuberculosis at 50 ug/ml measured at 1 hr interval for 15 hrs | 2017 | Journal of natural products, 12-22, Volume: 80, Issue:12 | Investigation of the Physical and Bioactive Properties of Bromo- and Iodo-Containing Sponge-Derived Compounds Possessing an Oxyphenylethanamine Core. |
| AID765043 | Antibacterial activity against Escherichia coli ATCC 35218 by MTT assay | 2013 | Bioorganic & medicinal chemistry, Sep-01, Volume: 21, Issue:17 | 3-Aryl-4-acyloxyethoxyfuran-2(5H)-ones as inhibitors of tyrosyl-tRNA synthetase: synthesis, molecular docking and antibacterial evaluation. |
| AID490132 | Antibacterial activity against Escherichia coli ATCC 35218 after 24 hrs by MTT assay | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Synthesis of some N-alkyl substituted urea derivatives as antibacterial and antifungal agents. |
| AID1079931 | Moderate liver toxicity, defined via clinical-chemistry results: ALT or AST serum activity 6 times the normal upper limit (N) or alkaline phosphatase serum activity of 1.7 N. Value is number of references indexed. [column 'BIOL' in source] | |||
| AID326542 | Antimicrobial activity against Mycobacterium abscessus NTU446 isolate after 3 to 5 days by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | In Vitro activities of isepamicin, other aminoglycosides, and capreomycin against clinical isolates of rapidly growing mycobacteria in Taiwan. |
| AID1055363 | Antibacterial activity against Escherichia coli after 18 hrs by turbidity assay | 2013 | Journal of natural products, Nov-22, Volume: 76, Issue:11 | Stereochemical assignment of the fungal metabolites pestalotiopsones D and E through enantiopure synthesis. |
| AID295900 | Antibacterial activity against Staphylococcus aureus ATCC 6538 after 24 hrs by MTT method | 2007 | Bioorganic & medicinal chemistry, Jun-15, Volume: 15, Issue:12 | Synthesis, structure, and structure-activity relationship analysis of enamines as potential antibacterials. |
| AID1287513 | Antibacterial activity against Escherichia coli NCIM 2688 after 8 hrs | 2016 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 26, Issue:7 | Synthesis, biological evaluation and molecular docking study of some novel indole and pyridine based 1,3,4-oxadiazole derivatives as potential antitubercular agents. |
| AID1326387 | Antibacterial activity against Bacillus subtilis P10C derived after 10 passage in presence of JBIR-100 after 16 to 18 hrs by microbroth dilution assay | 2016 | Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24 | Biological characterization of the hygrobafilomycin antibiotic JBIR-100 and bioinformatic insights into the hygrolide family of natural products. |
| AID1337848 | Antifungal activity against Cryptococcus neoformans NCIM 576 by standard agar method | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Quinolidene-rhodanine conjugates: Facile synthesis and biological evaluation. |
| AID1334268 | Antibacterial activity against Staphylococcus aureus | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2 | New bithiazolyl hydrazones: Novel synthesis, characterization and antitubercular evaluation. |
| AID1413339 | Antifungal activity against Aspergillus flavus | 2018 | MedChemComm, Jun-01, Volume: 9, Issue:6 | Antifungal amphiphilic kanamycins: new life for an old drug. |
| AID1862201 | Antimycobacterial activity against clinical isolate drug susceptible Mycobacterium tuberculosis H37Rv assessed as bacterial growth inhibition | 2022 | Bioorganic & medicinal chemistry letters, 09-15, Volume: 72 | Discovery and preclinical evaluations of JBD0131, a novel nitrodihydro-imidazooxazole anti-tuberculosis agent. |
| AID69129 | Inhibition of cell free transcription/translation by Escherichia coli s30 bacterial extract. | 2002 | Journal of medicinal chemistry, Aug-01, Volume: 45, Issue:16 | New inhibitors of bacterial protein synthesis from a combinatorial library of macrocycles. |
| AID1287979 | Antibacterial activity against Staphylococcus aureus after 18 hrs by broth dilution method | 2016 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 26, Issue:7 | Facile synthesis of 1,3-thiazolidin-4-ones as antitubercular agents. |
| AID69750 | Antibacterial activity expressed as MIC value was determined on Escherichia coli A-20697 organism | 1986 | Journal of medicinal chemistry, May, Volume: 29, Issue:5 | Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin. |
| AID1337785 | Antifungal activity against Fusarium oxysporum NCIM 1332 by standard agar method | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Quinolidene-rhodanine conjugates: Facile synthesis and biological evaluation. |
| AID540211 | Fraction unbound in human after iv administration | 2008 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7 | Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. |
| AID1710562 | Antibacterial activity against Escherichia coli ATCC 25922 assessed as reduction in bacterial growth incubated for 15 to 20 hrs by broth microdilution method | 2018 | MedChemComm, Jul-01, Volume: 9, Issue:7 | Targeting miRNA by tunable small molecule binders: peptidic aminosugar mediated interference in miR-21 biogenesis reverts epithelial to mesenchymal transition. |
| AID283544 | Antibacterial activity against Pseudomonas aeruginosa FE57GZ with inactivated rplY, nuoG and mexZ genes by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides. |
| AID1287978 | Antibacterial activity against Pseudomonas after 18 hrs by broth dilution method | 2016 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 26, Issue:7 | Facile synthesis of 1,3-thiazolidin-4-ones as antitubercular agents. |
| AID257552 | Antibacterial activity against Escherichia coli | 2005 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 15, Issue:23 | Synthesis and biological evaluation of novel (L)-alpha-amino acid methyl ester, heteroalkyl, and aryl substituted 1,4-naphthoquinone derivatives as antifungal and antibacterial agents. |
| AID1478538 | Inhibition of protein translation in Escherichia coli S30 cell extract using circular DNA with pBESTluc after 60 mins | 2017 | Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11 | Covalently linked kanamycin - Ciprofloxacin hybrid antibiotics as a tool to fight bacterial resistance. |
| AID425023 | Antimicrobial activity against Mycobacterium tuberculosis H37Ra by microplate alamar blue assay | 2009 | Journal of natural products, May-22, Volume: 72, Issue:5 | Biomimetic transformation and biological activities of Globiferin, a terpenoid benzoquinone from Cordia globifera. |
| AID278550 | Antimicrobial activity against 90 mins oxgall-stressed Bifidobacterium breve R0070 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID521575 | Reduction in light emission by Salmonella enterica serovars virchow isolate 101591 infected in mouse J774A.1 cells after 5 mins | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Aminoglycosides affect intracellular Salmonella enterica serovars typhimurium and virchow. |
| AID278546 | Antimicrobial activity against 90 mins oxgall-stressed Bifidobacterium bifidum R0071 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID1695864 | Antibacterial activity against Flavobacterium devorans ATCC 10829 incubated for 24 hrs | 2019 | European journal of medicinal chemistry, Apr-15, Volume: 168 | Comprehensive review on the anti-bacterial activity of 1,2,3-triazole hybrids. |
| AID521583 | Antibacterial activity against Salmonella enterica serovars Typhimurium ATCC 14028 infected in mouse J774A.1 macrophage assessed as log reduction in viable counts at 150 ug/ml after 1hr | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Aminoglycosides affect intracellular Salmonella enterica serovars typhimurium and virchow. |
| AID1565707 | Antifungal activity against azole-resistant Candida albicans 64124 incubated for 24 to 36 hrs by two fold dilution method | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Scalable and cost-effective tosylation-mediated synthesis of antifungal and fungal diagnostic 6″-Modified amphiphilic kanamycins. |
| AID1617679 | Antibacterial activity against Staphylococcus aureus 745524 by CLSI based two-fold serial dilution method | |||
| AID524388 | Antibacterial activity against Escherichia coli NKE1366 harboring deletion mutation in acrB and vector expressing mdtABC gene | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Effect of NlpE overproduction on multidrug resistance in Escherichia coli. |
| AID278544 | Antimicrobial activity against 60 min 1 M HCl-stressed Bifidobacterium thermophilum ATCC 25866 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID1765576 | Antibacterial activity against Staphylococcus epidermidis ATCC 12228 incubated for 18 hrs by CLSI based broth dilution method | 2021 | Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15 | Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice. |
| AID1182131 | Antitubercular activity against Mycobacterium smegmatis by checkerboard assay | 2014 | Bioorganic & medicinal chemistry, Aug-15, Volume: 22, Issue:16 | Pharmacologically active metabolites, combination screening and target identification-driven drug repositioning in antituberculosis drug discovery. |
| AID1164941 | Antimicrobial activity against Enterococcus faecalis ATCC 33186 by microbroth dilution method | 2014 | Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20 | Synthesis, structure-activity relationship studies, and antibacterial evaluation of 4-chromanones and chalcones, as well as olympicin A and derivatives. |
| AID445287 | Antibacterial activity against Mycobacterium avium SmO by broth dilution method | 2009 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 19, Issue:22 | Synthesis of new sugar derivatives and evaluation of their antibacterial activities against Mycobacterium tuberculosis. |
| AID1263040 | Antibacterial activity against Burkholderia thailandensis E264 at 1 mM after 24 to 48 hrs by Kirby-Bauer disc diffusion susceptibility test | 2015 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 25, Issue:24 | Synthesis and biological evaluation of pyrazolopyrimidines as potential antibacterial agents. |
| AID1079933 | Acute liver toxicity defined via clinical observations and clear clinical-chemistry results: serum ALT or AST activity > 6 N or serum alkaline phosphatases activity > 1.7 N. This category includes cytolytic, choleostatic and mixed liver toxicity. Value is | |||
| AID1426253 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | Synthesis and bioactivity investigation of quinone-based dimeric cationic triazolium amphiphiles selective against resistant fungal and bacterial pathogens. |
| AID381179 | Antibacterial activity against penicillin-resistant Staphylococcus aureus after 24 to 72 hrs by disk diffusion method | 1999 | Journal of natural products, Sep, Volume: 62, Issue:9 | Antimicrobial and antitumor activities of mycosporulone. |
| AID405455 | Antibacterial activity against Escherichia coli 1540 isolate by disk diffusion method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Transferable resistance to aminoglycosides by methylation of G1405 in 16S rRNA and to hydrophilic fluoroquinolones by QepA-mediated efflux in Escherichia coli. |
| AID1413327 | Antifungal activity against Candida lusitaniae 95-767 | 2018 | MedChemComm, Jun-01, Volume: 9, Issue:6 | Antifungal amphiphilic kanamycins: new life for an old drug. |
| AID326533 | Antimicrobial activity against Mycobacterium abscessus after 3 to 5 days by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | In Vitro activities of isepamicin, other aminoglycosides, and capreomycin against clinical isolates of rapidly growing mycobacteria in Taiwan. |
| AID445286 | Antibacterial activity against Mycobacterium avium 724S by broth dilution method | 2009 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 19, Issue:22 | Synthesis of new sugar derivatives and evaluation of their antibacterial activities against Mycobacterium tuberculosis. |
| AID556754 | Bactericidal activity against sodA, sodB gene-deficient Escherichia coli K-12 3156 after 18 hrs | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Contribution of oxidative damage to antimicrobial lethality. |
| AID1906417 | Antibacterial activity against imipenem resistant Klebsiella pneumoniae ATCC BAA 1705 assessed as reduction in microbial growth incubated for 24 hrs by microbroth dilution method | 2022 | European journal of medicinal chemistry, May-05, Volume: 235 | Amphiphilic cyclic peptide [W |
| AID369074 | Antimicrobial activity against Pseudomonas aeruginosa ATCC 13525 after 24 hrs by MTT assay | 2009 | Bioorganic & medicinal chemistry, Feb-01, Volume: 17, Issue:3 | Synthesis, structure and antibacterial activity of new 2-(1-(2-(substituted-phenyl)-5-methyloxazol-4-yl)-3-(2-substitued-phenyl)-4,5-dihydro-1H-pyrazol-5-yl)-7-substitued-1,2,3,4-tetrahydroisoquinoline derivatives. |
| AID1077164 | Antibacterial activity against Escherichia coli after 12 hrs by MTT assay | 2014 | European journal of medicinal chemistry, Apr-09, Volume: 76 | Design and synthesis of 2-styryl of 5-Nitroimidazole derivatives and antimicrobial activities as FabH inhibitors. |
| AID1207011 | Antibacterial activity against Micrococcus luteus assessed as growth inhibition at 5 ug/disc after 24 hrs by disc diffusion method | 2015 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 25, Issue:12 | An antibacterial ortho-quinone diterpenoid and its derivatives from Caryopteris mongolica. |
| AID278241 | Antimicrobial activity against Salmonella enterica serovar Typhimurium S21-3 gyrA+ with ParC S80I mutation | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials. |
| AID1624152 | Antitubercular activity against multidrug-resistant Mycobacterium tuberculosis isolate 4 after 7 days | 2019 | European journal of medicinal chemistry, Feb-15, Volume: 164 | Synthesis and evaluation of α-aminoacyl amides as antitubercular agents effective on drug resistant tuberculosis. |
| AID424831 | Antibacterial activity against kanamycin-resistant and fusidic acid-susceptible Staphylococcus aureus AH416 harboring deletion of nucleotide 395-398 in rplF gene after 18 to 24 hrs by Etest strip assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID556568 | Antimicrobial activity against katE gene-deficient Escherichia coli K-12 3202 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Contribution of oxidative damage to antimicrobial lethality. |
| AID560248 | Antibacterial activity against Staphylococcus aureus RN4220 harboring aadD, tet(L), dfrK and vga(C) gene by CLSI method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Novel ABC transporter gene, vga(C), located on a multiresistance plasmid from a porcine methicillin-resistant Staphylococcus aureus ST398 strain. |
| AID348956 | Antibacterial activity against Bacillus subtilis after 24 hrs by MTT assay | 2008 | European journal of medicinal chemistry, Jul, Volume: 43, Issue:7 | Synthesis and antimicrobial activities of 7-O-modified genistein derivatives. |
| AID1176774 | Antimicrobial activity against Escherichia coli ATCC 35218 after 24 hrs by broth microdilution method | 2015 | Journal of natural products, Jan-23, Volume: 78, Issue:1 | Structure and antimicrobial activity of phloroglucinol derivatives from Achyrocline satureioides. |
| AID424610 | Antibacterial activity against kanamycin-resistant and fusidic acid-susceptible Staphylococcus aureus AH421 harboring Pro404Arg mutation in fusA gene after 18 to 24 hrs by Etest strip assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID1287514 | Antibacterial activity against Pseudomonas fluorescens NCIM 2036 after 8 hrs | 2016 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 26, Issue:7 | Synthesis, biological evaluation and molecular docking study of some novel indole and pyridine based 1,3,4-oxadiazole derivatives as potential antitubercular agents. |
| AID1413337 | Antifungal activity against Fusarium graminearum B-4-5A | 2018 | MedChemComm, Jun-01, Volume: 9, Issue:6 | Antifungal amphiphilic kanamycins: new life for an old drug. |
| AID1890845 | Selectivity index, ratio of MIC50 for antimycobacterial activity against Mycobacterium smegmatis mc2 155 harbouring pMyC empty vector to MIC50 for antimycobacterial activity against wild type Mycobacterium smegmatis mc2 155 | 2022 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 64 | Design, synthesis and antibacterial activity against pathogenic mycobacteria of conjugated hydroxamic acids, hydrazides and O-alkyl/O-acyl protected hydroxamic derivatives. |
| AID1079940 | Granulomatous liver disease, proven histopathologically. Value is number of references indexed. [column 'GRAN' in source] | |||
| AID425071 | Antimicrobial activity against Escherichia coli J53-AzR in presence of IPTG | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Complex class 1 integrons with diverse variable regions, including aac(6')-Ib-cr, and a novel allele, qnrB10, associated with ISCR1 in clinical enterobacterial isolates from Argentina. |
| AID278259 | Antimicrobial activity against Salmonella enterica serovar Typhimurium CS9 tolC::Kan with GyrA S83F, D87N, ParC S80I mutation | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials. |
| AID283536 | Antibacterial activity against Pseudomonas aeruginosa FE53U with inactivated mexZ and galU genes by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides. |
| AID520873 | Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus saprophyticus isolate TSU69 isolated from genitourinary tracts of acute cystitis patient after 24 hrs at 35 degC by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Methicillin-resistant Staphylococcus saprophyticus isolates carrying staphylococcal cassette chromosome mec have emerged in urogenital tract infections. |
| AID1629130 | Antimicrobial activity against aminoglycoside-resistant Burkholderia cepacia ATCC 25416 measured after 24 hrs by double-dilution method | 2016 | Journal of medicinal chemistry, 09-08, Volume: 59, Issue:17 | Effects of 5-O-Ribosylation of Aminoglycosides on Antimicrobial Activity and Selective Perturbation of Bacterial Translation. |
| AID774298 | Antimycobacterial activity against rifampin-resistant Mycobacterium tuberculosis ATCC 35838 | 2013 | Journal of natural products, Oct-25, Volume: 76, Issue:10 | Chlorinated coumarins from the polypore mushroom Fomitopsis officinalis and their activity against Mycobacterium tuberculosis. |
| AID348958 | Antibacterial activity against Pseudomonas fluorescens after 24 hrs by MTT assay | 2008 | European journal of medicinal chemistry, Jul, Volume: 43, Issue:7 | Synthesis and antimicrobial activities of 7-O-modified genistein derivatives. |
| AID1617678 | Antibacterial activity against Staphylococcus aureus ATCC 292132 by CLSI based two-fold serial dilution method | |||
| AID278541 | Antimicrobial activity against 60 min 1 M HCl-stressed Bifidobacterium longum R0175 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID540927 | Antimicrobial activity against Streptomyces coelicolor 1147 after 48 hrs | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | A novel insertion mutation in Streptomyces coelicolor ribosomal S12 protein results in paromomycin resistance and antibiotic overproduction. |
| AID556755 | Bactericidal activity against katG gene-deficient Escherichia coli K-12 3157 after 18 hrs | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Contribution of oxidative damage to antimicrobial lethality. |
| AID1202741 | Antimicrobial activity against Staphylococcus aureus assessed as reduction in bacterial growth incubated for 48 hrs by microbroth dilution method | 2015 | Journal of natural products, Feb-27, Volume: 78, Issue:2 | Prenylated benzophenones from Triadenum japonicum. |
| AID274302 | Inhibition of protein synthesis in Escherichia coli S30 extracts by coupled transcription-translation assay | 2006 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 16, Issue:20 | Structure-activity relationships of novel antibacterial translation inhibitors: 3,5-diamino-piperidinyl triazines. |
| AID295899 | Antibacterial activity against Pseudomonas fluorescens ATCC 13525 after 24 hrs by MTT method | 2007 | Bioorganic & medicinal chemistry, Jun-15, Volume: 15, Issue:12 | Synthesis, structure, and structure-activity relationship analysis of enamines as potential antibacterials. |
| AID278262 | Antimicrobial activity against Salmonella enterica serovar Typhimurium CHS14 acrAB::Kan with GyrA D87G mutation | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials. |
| AID1169516 | Antibacterial activity against Bacillus subtilis after 24 hrs by MTT method | 2014 | Bioorganic & medicinal chemistry letters, Sep-28 | Design, synthesis and biological evaluation of metronidazole-thiazole derivatives as antibacterial inhibitors. |
| AID1169516 | Antibacterial activity against Bacillus subtilis after 24 hrs by MTT method | 2014 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22 | Design, synthesis and biological evaluation of metronidazole-thiazole derivatives as antibacterial inhibitors. |
| AID1207002 | Antibacterial activity against Staphylococcus aureus assessed as growth inhibition at 5 ug/disc after 24 hrs by disc diffusion method | 2015 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 25, Issue:12 | An antibacterial ortho-quinone diterpenoid and its derivatives from Caryopteris mongolica. |
| AID1337800 | Antibacterial activity against of Staphylococcus aureus NCIM 2010 measured after 12 hrs | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Quinolidene-rhodanine conjugates: Facile synthesis and biological evaluation. |
| AID1265787 | Antibacterial activity against methicillin-resistant Staphylococcus aureus by microdilution method | 2015 | Journal of medicinal chemistry, Dec-10, Volume: 58, Issue:23 | Synthesis and Bioactivities of Kanamycin B-Derived Cationic Amphiphiles. |
| AID145295 | Tested for antibacterial activity against Mycobacterium tuberculosis H37Rv isonicotinic acid hydrazide-resistant strain | 1985 | Journal of medicinal chemistry, Dec, Volume: 28, Issue:12 | Synthesis and antibacterial activity of 2,2'-dithiobis(benzamide) derivatives against Mycobacterium species. |
| AID278552 | Antimicrobial activity against 90 mins oxgall-stressed Bifidobacterium longum ATCC 15707 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID521580 | Antibacterial activity against Salmonella enterica serovars Typhimurium ATCC 14028 assessed as log reduction in viable counts at 150 ug/ml after 1hr | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Aminoglycosides affect intracellular Salmonella enterica serovars typhimurium and virchow. |
| AID428873 | Antibacterial activity against Escherichia coli JM109 carrying pMCL210 by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Novel plasmid-mediated 16S rRNA m1A1408 methyltransferase, NpmA, found in a clinically isolated Escherichia coli strain resistant to structurally diverse aminoglycosides. |
| AID1730993 | Antitubercular activity against isoniazid/rifampin resistance Mycobacterium tuberculosis KZN494 by MABA assay | 2021 | European journal of medicinal chemistry, Mar-05, Volume: 213 | Design and synthesis of mycobacterial pks13 inhibitors: Conformationally rigid tetracyclic molecules. |
| AID1169517 | Inhibition of Escherichia coli FabH | 2014 | Bioorganic & medicinal chemistry letters, Sep-28 | Design, synthesis and biological evaluation of metronidazole-thiazole derivatives as antibacterial inhibitors. |
| AID1169517 | Inhibition of Escherichia coli FabH | 2014 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22 | Design, synthesis and biological evaluation of metronidazole-thiazole derivatives as antibacterial inhibitors. |
| AID510748 | Antibacterial activity against Escherichia coli AG102MB harboring naive acrB gene | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Single nucleotide polymorphism analysis of the major tripartite multidrug efflux pump of Escherichia coli: functional conservation in disparate animal reservoirs despite exposure to antimicrobial chemotherapy. |
| AID278553 | Antimicrobial activity against 90 mins oxgall-stressed Bifidobacterium longum ATCC 15708 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID625291 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver function tests abnormal | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID290148 | Antifungal activity against Aspergillus niger after 48 hrs by MTT colorimetric method | 2007 | European journal of medicinal chemistry, Apr, Volume: 42, Issue:4 | Synthesis and antimicrobial activities of Schiff bases derived from 5-chloro-salicylaldehyde. |
| AID1629128 | Antimicrobial activity against Escherichia coli ATCC 25922 measured after 24 hrs by double-dilution method | 2016 | Journal of medicinal chemistry, 09-08, Volume: 59, Issue:17 | Effects of 5-O-Ribosylation of Aminoglycosides on Antimicrobial Activity and Selective Perturbation of Bacterial Translation. |
| AID1663463 | Antibacterial activity against Staphylococcus aureus ATCC 6538 incubated for 16 hrs by broth microdilution method | 2020 | Journal of natural products, 06-26, Volume: 83, Issue:6 | Antibacterial Pentacyclic Polyketides from a Soil-Derived |
| AID537734 | Antifungal activity against yeast AD1-8u expressing Candida albicans CaMdr1p by agar disk diffusion assay | 2010 | European journal of medicinal chemistry, Nov, Volume: 45, Issue:11 | Analysis of physico-chemical properties of substrates of ABC and MFS multidrug transporters of pathogenic Candida albicans. |
| AID1348084 | Antimicrobial activity against Candida albicans ATCC 10231 assessed as zone of inhibition at 50 ug per disc after 48 hrs by disc diffusion assay | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Synthesis of new 1-benzyl tetrahydropyridinylidene ammonium salts and their antimicrobial and anticellular activities. |
| AID445290 | Antibacterial activity against Escherichia coli by broth dilution method | 2009 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 19, Issue:22 | Synthesis of new sugar derivatives and evaluation of their antibacterial activities against Mycobacterium tuberculosis. |
| AID1326388 | Antibacterial activity against Bacillus subtilis P10A derived after 10 passage in presence of JBIR-100 after 16 to 18 hrs by microbroth dilution assay relative to Bacillus subtilis ATCC 47096 | 2016 | Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24 | Biological characterization of the hygrobafilomycin antibiotic JBIR-100 and bioinformatic insights into the hygrolide family of natural products. |
| AID1349917 | Antimicrobial activity against Mycobacterium smegmatis DSM 44200 after 16 to 48 hrs by serial dilution method | 2018 | Journal of natural products, 02-23, Volume: 81, Issue:2 | Cysteine-Derived Pleurotin Congeners from the Nematode-Trapping Basidiomycete Hohenbuehelia grisea. |
| AID405816 | Antimicrobial activity against Escherichia coli DH5alpha harboring recombinant pIMPAR31 | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Characterization of an integron carrying blaIMP-1 and a new aminoglycoside resistance gene, aac(6')-31, and its dissemination among genetically unrelated clinical isolates in a Brazilian hospital. |
| AID534419 | Antibacterial activity against Mycobacterium bovis BCG-Connaught | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Susceptibility of Mycobacterium bovis BCG vaccine strains to antituberculous antibiotics. |
| AID601496 | Antibacterial activity against Klebsiella pneumoniae MTCC 139 at 30 ug/disc after 24 hrs | 2011 | European journal of medicinal chemistry, Jun, Volume: 46, Issue:6 | Evaluation of antioxidant and antimicrobial activities of Bergenin and its derivatives obtained by chemoenzymatic synthesis. |
| AID522879 | Antibacterial activity against uropathogenic Escherichia coli UTI89 infected in human 5637 cells assessed as decrease in intracellular bacterial level at 1000 to 3000 ug/ml after 12 hrs by serial dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Persistence of uropathogenic Escherichia coli in the face of multiple antibiotics. |
| AID326534 | Antimicrobial activity against Mycobacterium chelonae after 3 to 5 days by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | In Vitro activities of isepamicin, other aminoglycosides, and capreomycin against clinical isolates of rapidly growing mycobacteria in Taiwan. |
| AID326537 | Antimicrobial activity against Mycobacterium abscessus R31 isolate after 3 to 5 days by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | In Vitro activities of isepamicin, other aminoglycosides, and capreomycin against clinical isolates of rapidly growing mycobacteria in Taiwan. |
| AID278806 | Antimicrobial activity against Stenotrophomonas maltophilia K279a (aph FS) mutant | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Aph(3')-IIc, an aminoglycoside resistance determinant from Stenotrophomonas maltophilia. |
| AID326540 | Antimicrobial activity against Mycobacterium abscessus NTU459 isolate after 3 to 5 days by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | In Vitro activities of isepamicin, other aminoglycosides, and capreomycin against clinical isolates of rapidly growing mycobacteria in Taiwan. |
| AID1455935 | Antibacterial activity against Bacillus subtilis after 48 hrs by broth micro-dilution method | 2017 | Journal of natural products, 02-24, Volume: 80, Issue:2 | Nabscessins A and B, Aminocyclitol Derivatives from Nocardia abscessus IFM 10029 |
| AID325446 | Antibacterial activity against Salmonella enterica serovar Typhimurium LT2 after 14 to 16 hrs by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Polyamine effects on antibiotic susceptibility in bacteria. |
| AID523021 | Activity at aminoglycoside 3'-phosphotransferase 1B by PK/LDH-coupled assay in presence of GTP | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Nucleotide selectivity of antibiotic kinases. |
| AID1113098 | Antibacterial activity against Escherichia coli after 24 hr by microdilution method | 2013 | Journal of agricultural and food chemistry, Mar-27, Volume: 61, Issue:12 | Isolation and characterization of new p-Terphenyls with antifungal, antibacterial, and antioxidant activities from halophilic actinomycete Nocardiopsis gilva YIM 90087. |
| AID647790 | Antibacterial activity Bacillus subtilis at 40 ug/disc after 24 hrs by agar disc diffusion method | 2012 | European journal of medicinal chemistry, Apr, Volume: 50 | Synthesis of new α aminophosphonate system bearing Indazole moiety and their biological activity. |
| AID424584 | Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH367 (SCV-39) harboring Gly664Ser mutation in fusA gene after 18 to 24 hrs by Etest strip assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID278230 | Antimicrobial activity against Salmonella enterica serovar Typhimurium S21 acrAB::Kan | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials. |
| AID1478527 | Antibacterial activity against Escherichia coli BL21 by double microdilution method | 2017 | Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11 | Covalently linked kanamycin - Ciprofloxacin hybrid antibiotics as a tool to fight bacterial resistance. |
| AID1887299 | Antibacterial activity against Bacillus subtilis ATCC 11774 assessed as inhibition of bacterial growth incubated for 24 hrs by optical density based analysis | 2022 | Journal of natural products, 09-23, Volume: 85, Issue:9 | Total Syntheses and Antibacterial Evaluations of Neocyclomorusin and Related Flavones. |
| AID1869576 | Bactericidal activity against Enterobacter cloacae DSM 30054 assessed as reduction in colony count and measured after 3 days by agar diffusion assay | 2022 | Journal of natural products, 06-24, Volume: 85, Issue:6 | Triculamin: An Unusual Lasso Peptide with Potent Antimycobacterial Activity. |
| AID1710564 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 assessed as reduction in bacterial growth incubated for 15 to 20 hrs by broth microdilution method | 2018 | MedChemComm, Jul-01, Volume: 9, Issue:7 | Targeting miRNA by tunable small molecule binders: peptidic aminosugar mediated interference in miR-21 biogenesis reverts epithelial to mesenchymal transition. |
| AID1164942 | Antimicrobial activity against methicillin-sensitive Staphylococcus aureus ATCC 29213 by microbroth dilution method | 2014 | Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20 | Synthesis, structure-activity relationship studies, and antibacterial evaluation of 4-chromanones and chalcones, as well as olympicin A and derivatives. |
| AID293865 | Antimicrobial activity against Escherichia coli ATCC 25922 after 24 hrs by two fold dilution method | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6 | Synthesis of pseudopeptides based L-tryptophan as a potential antimicrobial agent. |
| AID625285 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatic necrosis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID1585672 | Antibacterial activity against methicillin-resistant Staphylococcus haemolyticus assessed as zone of inhibition at 30 ug/mL after 24 hrs by agar disc diffusion method | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Discovery of novel arylethenesulfonyl fluorides as potential candidates against methicillin-resistant of Staphylococcus aureus (MRSA) for overcoming multidrug resistance of bacterial infections. |
| AID326552 | Antimicrobial activity against Mycobacterium fortuitum V61 isolate after 3 to 5 days by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | In Vitro activities of isepamicin, other aminoglycosides, and capreomycin against clinical isolates of rapidly growing mycobacteria in Taiwan. |
| AID1617682 | Antibacterial activity against Bacillus subtilis BS01 by CLSI based two-fold serial dilution method | |||
| AID206014 | Minimum inhibitory concentration (MIC) was measured against Staphylococcus aureus. | 1995 | Journal of medicinal chemistry, Nov-10, Volume: 38, Issue:23 | Synthesis and antimicrobial and toxicological studies of amino acid and peptide derivatives of kanamycin A and netilmicin. |
| AID1055365 | Antibacterial activity against Staphylococcus epidermidis after 18 hrs by turbidity assay | 2013 | Journal of natural products, Nov-22, Volume: 76, Issue:11 | Stereochemical assignment of the fungal metabolites pestalotiopsones D and E through enantiopure synthesis. |
| AID163076 | Antibacterial activity expressed as MIC value was determined on Proteus stuartii A-21210 organism | 1986 | Journal of medicinal chemistry, May, Volume: 29, Issue:5 | Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin. |
| AID584330 | Antibacterial activity against ygiBC, yjfMC, gspS deficient Escherichia coli GD108 | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics. |
| AID1250523 | Antibacterial activity against Escherichia coli ATCC 8739 after 24 hr by MTT assay | 2015 | European journal of medicinal chemistry, Sep-18, Volume: 102 | Synthesis and evaluation of new tyrosyl-tRNA synthetase inhibitors as antibacterial agents based on a N2-(arylacetyl)glycinanilide scaffold. |
| AID326543 | Antimicrobial activity against Mycobacterium abscessus R47 isolate after 3 to 5 days by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | In Vitro activities of isepamicin, other aminoglycosides, and capreomycin against clinical isolates of rapidly growing mycobacteria in Taiwan. |
| AID1105401 | Antibacterial activity against Bacillus pumilus MTCC 2466 assessed as growth inhibition at 25 ug/disk after 24 hr by disk diffusion method | 2013 | European journal of medicinal chemistry, Jan, Volume: 59 | Microwave synthesis, characterization and bio-efficacy evaluation of novel chalcone based 6-carbethoxy-2-cyclohexen-1-one and 2H-indazol-3-ol derivatives. |
| AID1263042 | Antibacterial activity against Burkholderia thailandensis E264 at 0.1 mM after 24 to 48 hrs by Kirby-Bauer disc diffusion susceptibility test | 2015 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 25, Issue:24 | Synthesis and biological evaluation of pyrazolopyrimidines as potential antibacterial agents. |
| AID1193541 | Antibacterial activity against Escherichia coli ATCC 25922 at 100 ug after 24 hrs | 2015 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 25, Issue:7 | Synthesis of 3-azabicyclo[3.2.2]nonanes and their antiprotozoal activities. |
| AID1105400 | Antibacterial activity against Klebsiella pneumoniae MTCC 7028 assessed as growth inhibition at 25 ug/disk after 24 hr by disk diffusion method | 2013 | European journal of medicinal chemistry, Jan, Volume: 59 | Microwave synthesis, characterization and bio-efficacy evaluation of novel chalcone based 6-carbethoxy-2-cyclohexen-1-one and 2H-indazol-3-ol derivatives. |
| AID278538 | Antimicrobial activity against 60 min 1 M HCl-stressed Bifidobacterium breve R0070 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID532985 | Antibacterial activity against Escherichia coli MG1655 | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | N-acetylcysteine-mediated modulation of bacterial antibiotic susceptibility. |
| AID207042 | Antibacterial activity expressed as MIC value was determined on Staphylococcus aureus A-22231 organism | 1986 | Journal of medicinal chemistry, May, Volume: 29, Issue:5 | Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin. |
| AID1478526 | Antibacterial activity against aminoglycosides-susceptible Staphylococcus epidermidis by double microdilution method | 2017 | Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11 | Covalently linked kanamycin - Ciprofloxacin hybrid antibiotics as a tool to fight bacterial resistance. |
| AID524382 | Antibacterial activity against Escherichia coli NKE160 harboring deletion mutation in acrB protein and vector expressing tolC gene | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Effect of NlpE overproduction on multidrug resistance in Escherichia coli. |
| AID326550 | Antimicrobial activity against Mycobacterium abscessus V120 isolate after 3 to 5 days by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | In Vitro activities of isepamicin, other aminoglycosides, and capreomycin against clinical isolates of rapidly growing mycobacteria in Taiwan. |
| AID1636357 | Drug activation in human Hep3B cells assessed as human CYP3A4-mediated drug metabolism-induced cytotoxicity measured as decrease in cell viability at 300 uM pre-incubated with BSO for 18 hrs followed by incubation with compound for 3 hrs in presence of NA | 2016 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 26, Issue:16 | Development of a cell viability assay to assess drug metabolite structure-toxicity relationships. |
| AID587759 | Antimicrobial activity against Mycobacterium ulcerans Mu1059 expressing luxAB from vibrio harveyi infected BALB/c mouse assessed as reduction in foodpad CFU count after 4 weeks | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Using bioluminescence to monitor treatment response in real time in mice with Mycobacterium ulcerans infection. |
| AID1868103 | Antibacterial activity against Mycobacterium smegmatis ATCC 607 assessed as inhibition of visible bacterial growth incubated for 48 hrs by CLSI protocol based assay | 2022 | Journal of natural products, 05-27, Volume: 85, Issue:5 | Enceleamycins A-C, Furo-Naphthoquinones from |
| AID625286 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatitis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID697852 | Inhibition of electric eel AChE at 2 mg/ml by Ellman's method | 2012 | Bioorganic & medicinal chemistry, Nov-15, Volume: 20, Issue:22 | Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine. |
| AID1299588 | Antibiofilm activity against Pseudomonas aeruginosa PAO1 ATCC 47085 at < 1024 ug/ml after 24 hrs by crystal violet staining-based spectrophotometry | 2016 | Journal of medicinal chemistry, Apr-14, Volume: 59, Issue:7 | Antibacterial Diamines Targeting Bacterial Membranes. |
| AID565230 | Antimicrobial activity against Mycobacterium chelonae 9917 by resazurine microtiter assay | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Role of porins in the susceptibility of Mycobacterium smegmatis and Mycobacterium chelonae to aldehyde-based disinfectants and drugs. |
| AID569258 | Antimycobacterial activity against Mycobacterium avium subsp. hominissuis 104 | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Synthesis and evaluation of anti-tubercular activity of new dithiocarbamate sugar derivatives. |
| AID342022 | Antibacterial activity against plasmid pK29 transconjugant Escherichia coli J53 by broth microdilution test | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Sequencing and comparative genomic analysis of pK29, a 269-kilobase conjugative plasmid encoding CMY-8 and CTX-M-3 beta-lactamases in Klebsiella pneumoniae. |
| AID476720 | Antibacterial activity against Escherichia coli ATCC 35218 after 24 hrs by colorimetric method using dye MTT | 2010 | Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7 | Synthesis, molecular modeling and biological evaluation of PSB as targeted antibiotics. |
| AID521590 | Antibacterial activity against Salmonella enterica serovars virchow isolate 101591 at pH 5.7 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Aminoglycosides affect intracellular Salmonella enterica serovars typhimurium and virchow. |
| AID1478524 | Antibacterial activity against aminoglycosides-susceptible Escherichia coli 25922 by double microdilution method | 2017 | Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11 | Covalently linked kanamycin - Ciprofloxacin hybrid antibiotics as a tool to fight bacterial resistance. |
| AID1765580 | Antibacterial activity against Acinetobacter baumannii ATCC 19606 incubated for 18 hrs by CLSI based broth dilution method | 2021 | Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15 | Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice. |
| AID1296451 | Inhibition of RNA biosynthesis in Mycobacterium tuberculosis H37Ra assessed as reduction of [14C]-uracil incorporation at 5 ug/ml preincubated for 1 hr followed by radiolabeling with [14C]-uracil for 24 hrs by scintillation spectrometry | 2016 | Journal of medicinal chemistry, Mar-24, Volume: 59, Issue:6 | Development of 3,5-Dinitrobenzylsulfanyl-1,3,4-oxadiazoles and Thiadiazoles as Selective Antitubercular Agents Active Against Replicating and Nonreplicating Mycobacterium tuberculosis. |
| AID1890844 | Antimycobacterial activity against Mycobacterium smegmatis mc2 155 harbouring pMyC::PDFMtb overexpression mutant assessed as inhibition of mycobacterial growth incubated for 3 to 5 days by resazurin microtiter assay | 2022 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 64 | Design, synthesis and antibacterial activity against pathogenic mycobacteria of conjugated hydroxamic acids, hydrazides and O-alkyl/O-acyl protected hydroxamic derivatives. |
| AID534338 | Antimicrobial activity against Burkholderia pseudomallei Bp250 harboring mini-Tn7T-bpeA+B+ -oprB+ after 24 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | The BpeAB-OprB efflux pump of Burkholderia pseudomallei 1026b does not play a role in quorum sensing, virulence factor production, or extrusion of aminoglycosides but is a broad-spectrum drug efflux system. |
| AID1617941 | Antibacterial activity against Micrococcus luteus ATCC 15307 after 16 to 48 hrs | 2019 | Journal of natural products, 12-27, Volume: 82, Issue:12 | Structure Determination, Functional Characterization, and Biosynthetic Implications of Nybomycin Metabolites from a Mining Reclamation Site-Associated |
| AID290147 | Antibacterial activity against Staphylococcus aureus after 24 hrs by MTT colorimetric method | 2007 | European journal of medicinal chemistry, Apr, Volume: 42, Issue:4 | Synthesis and antimicrobial activities of Schiff bases derived from 5-chloro-salicylaldehyde. |
| AID520703 | Antibacterial activity against aphA-3 positive tetracycline resistant Streptococcus pneumoniae clinical isolate expressing Tn6003 carrying erm(B)and tet(M) gene at 1000 ug by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | erm(B)-carrying elements in tetracycline-resistant pneumococci and correspondence between Tn1545 and Tn6003. |
| AID1287515 | Antibacterial activity against Staphylococcus aureus NCIM 2010 after 12 hrs | 2016 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 26, Issue:7 | Synthesis, biological evaluation and molecular docking study of some novel indole and pyridine based 1,3,4-oxadiazole derivatives as potential antitubercular agents. |
| AID325443 | Antibacterial activity against Escherichia coli K10 after 14 to 16 hrs by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Polyamine effects on antibiotic susceptibility in bacteria. |
| AID1306202 | Antibacterial activity against Escherichia coli ATCC 25922 after 18 hrs by microbroth dilution assay | 2016 | Bioorganic & medicinal chemistry, 07-15, Volume: 24, Issue:14 | The influence of halogen substituents on the biological properties of sulfur-containing flavonoids. |
| AID1182153 | Ratio of MIC99 for Mycobacterium smegmatis to ratio of MIC99 for Mycobacterium smegmatis in presence of nor-chlorpromazine | 2014 | Bioorganic & medicinal chemistry, Aug-15, Volume: 22, Issue:16 | Pharmacologically active metabolites, combination screening and target identification-driven drug repositioning in antituberculosis drug discovery. |
| AID537736 | Antifungal activity against yeast AD1-8u expressing Candida albicans CaCdr1p by agar disk diffusion assay | 2010 | European journal of medicinal chemistry, Nov, Volume: 45, Issue:11 | Analysis of physico-chemical properties of substrates of ABC and MFS multidrug transporters of pathogenic Candida albicans. |
| AID523019 | Activity at aminoglycoside 3'-phosphotransferase 1B by PK/LDH-coupled assay in presence of ATP | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Nucleotide selectivity of antibiotic kinases. |
| AID501182 | Antimicrobial activity against Escherichia coli 442 at 30 ug after 18 hrs by agar diffusion method | 2009 | Journal of natural products, Oct, Volume: 72, Issue:10 | Norselic acids A-E, highly oxidized anti-infective steroids that deter mesograzer predation, from the Antarctic sponge Crella sp. |
| AID405081 | Antimicrobial activity against Escherichia coli CAG12177 by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Biochemical characterization of PER-2 and genetic environment of blaPER-2. |
| AID1056539 | Antibacterial activity against Acinetobacter baumannii ATCC 19606 by broth microdilution method | 2013 | Journal of natural products, Dec-27, Volume: 76, Issue:12 | Cytotoxic and antibacterial marfuraquinocins from the deep South China Sea-derived Streptomyces niveus SCSIO 3406. |
| AID424348 | Antibacterial activity against fusidic acid-resistant Staphylococcus aureus AH202 harboring CTG start codon at nucleotide 1 in rplF gene after 18 to 24 hrs by Etest strip assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID1413336 | Antifungal activity against sensitive Candida parapsilosis | 2018 | MedChemComm, Jun-01, Volume: 9, Issue:6 | Antifungal amphiphilic kanamycins: new life for an old drug. |
| AID584114 | Antibacterial activity against Escherichia coli KAM32 harboring Staphylococcus aureus cloned pSP72 lmrS by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | LmrS is a multidrug efflux pump of the major facilitator superfamily from Staphylococcus aureus. |
| AID520423 | Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus saprophyticus isolate TSU18 isolated from genitourinary tracts of acute cystitis patient after 24 hrs at 35 degC by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Methicillin-resistant Staphylococcus saprophyticus isolates carrying staphylococcal cassette chromosome mec have emerged in urogenital tract infections. |
| AID1055362 | Antibacterial activity against Mycobacterium smegmatis after 18 hrs by turbidity assay | 2013 | Journal of natural products, Nov-22, Volume: 76, Issue:11 | Stereochemical assignment of the fungal metabolites pestalotiopsones D and E through enantiopure synthesis. |
| AID424615 | Antibacterial activity against kanamycin-resistant and fusidic acid-susceptible Staphylococcus aureus AH297 harboring Ser660Pro mutation in fusA gene after 18 to 24 hrs by Etest strip assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID1862200 | Antimycobacterial activity against clinical isolate multidrug resistant Mycobacterium tuberculosis H37Rv assessed as bacterial growth inhibition | 2022 | Bioorganic & medicinal chemistry letters, 09-15, Volume: 72 | Discovery and preclinical evaluations of JBD0131, a novel nitrodihydro-imidazooxazole anti-tuberculosis agent. |
| AID424592 | Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH392 (SCV-64) harboring -1 frameshift mutation at nucleotide 383 in rplF gene after 18 to 24 hrs by Etest strip assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID1455938 | Antifungal activity against Candida albicans after 48 hrs by broth micro-dilution method | 2017 | Journal of natural products, 02-24, Volume: 80, Issue:2 | Nabscessins A and B, Aminocyclitol Derivatives from Nocardia abscessus IFM 10029 |
| AID1473738 | Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to 20 mins by membrane vesicle transport assay | 2013 | Toxicological sciences : an official journal of the Society of Toxicology, Nov, Volume: 136, Issue:1 | A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. |
| AID1055951 | Antibacterial activity against Acinetobacter baumannii ATCC BAA-747 after 16 hrs | 2013 | Journal of natural products, Nov-22, Volume: 76, Issue:11 | Hytramycins V and I, anti-Mycobacterium tuberculosis hexapeptides from a Streptomyces hygroscopicus strain. |
| AID126450 | Dissociation constant for binding to mitochondrial 12S rRNA construct M3 was determined | 2002 | Bioorganic & medicinal chemistry letters, Aug-19, Volume: 12, Issue:16 | Decoding region bubble size and aminoglycoside antibiotic binding. |
| AID293205 | Antibacterial activity against Escherichia coli ATCC 25922 by disc diffusion method | 2007 | Bioorganic & medicinal chemistry, Feb-01, Volume: 15, Issue:3 | Parallel solid synthesis of inhibitors of the essential cell division FtsZ enzyme as a new potential class of antibacterials. |
| AID1167356 | Antibacterial activity against Escherichia coli D21 IpxC101/tolC deletion mutant after 18 to 24 hrs by two-fold broth microdilution method | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21 | Design, synthesis, and antibacterial properties of dual-ligand inhibitors of acetyl-CoA carboxylase. |
| AID404903 | Antibacterial activity against Streptococcus bovis ATCC 33317 by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | High-level gentamicin resistance mediated by a Tn4001-like transposon in seven nonclonal hospital isolates of Streptococcus pasteurianus. |
| AID1164943 | Antimicrobial activity against Escherichia coli K-12 by microbroth dilution method | 2014 | Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20 | Synthesis, structure-activity relationship studies, and antibacterial evaluation of 4-chromanones and chalcones, as well as olympicin A and derivatives. |
| AID1473741 | Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and GSH measured after 20 mins by membrane vesicle transport assay | 2013 | Toxicological sciences : an official journal of the Society of Toxicology, Nov, Volume: 136, Issue:1 | A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. |
| AID1868108 | Antibacterial activity against Escherichia coli ATCC 8739 assessed as inhibition of visible bacterial growth incubated for 18 hrs by CLSI protocol based assay | 2022 | Journal of natural products, 05-27, Volume: 85, Issue:5 | Enceleamycins A-C, Furo-Naphthoquinones from |
| AID1271378 | Antimicrobial activity against Gram-positive Bacillus subtilis 168 after 16 to 24 hrs by micro-dilution method | 2015 | ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11 | Synthesis and Biological Activity of Mono- and Di-N-acylated Aminoglycosides. |
| AID1225388 | Antibacterial activity against Escherichia coli transformed with plasmid carrying MG1655 deltaBC/pABM by p-iodonitrotetrazolium chloride colorimetric assay | 2015 | Journal of natural products, Mar-27, Volume: 78, Issue:3 | Enhancement of antibiotic activity against multidrug-resistant bacteria by the efflux pump inhibitor 3,4-dibromopyrrole-2,5-dione isolated from a Pseudoalteromonas sp. |
| AID1868102 | Antibacterial activity against Listeria monocytogenes ATCC19111 assessed as inhibition of visible bacterial growth incubated for 18 hrs by CLSI protocol based assay | 2022 | Journal of natural products, 05-27, Volume: 85, Issue:5 | Enceleamycins A-C, Furo-Naphthoquinones from |
| AID1056540 | Antibacterial activity against Staphylococcus aureus ATCC 29213 by broth microdilution method | 2013 | Journal of natural products, Dec-27, Volume: 76, Issue:12 | Cytotoxic and antibacterial marfuraquinocins from the deep South China Sea-derived Streptomyces niveus SCSIO 3406. |
| AID1271379 | Antimicrobial activity against Gram-positive Listeria monocytogenes ATCC 19115 after 16 to 24 hrs by micro-dilution method | 2015 | ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11 | Synthesis and Biological Activity of Mono- and Di-N-acylated Aminoglycosides. |
| AID560590 | Antimicrobial activity against Pseudomonas aeruginosa isolate IMCJ798 by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | AAC(6')-Iaf, a novel aminoglycoside 6'-N-acetyltransferase from multidrug-resistant Pseudomonas aeruginosa clinical isolates. |
| AID1261214 | Bacteriostatic activity against Staphylococcus aureus Mu50 after 24 hrs | 2015 | Bioorganic & medicinal chemistry, Nov-01, Volume: 23, Issue:21 | Evaluation of small molecule SecA inhibitors against methicillin-resistant Staphylococcus aureus. |
| AID718275 | Antimicrobial activity against Micrococcus luteus | 2012 | Journal of natural products, Dec-28, Volume: 75, Issue:12 | Marthiapeptide A, an anti-infective and cytotoxic polythiazole cyclopeptide from a 60 L scale fermentation of the deep sea-derived Marinactinospora thermotolerans SCSIO 00652. |
| AID368419 | Antimicrobial activity against Escherichia coli KAM32 expressing deltaacrB ydhE hsd gene by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | New plasmid-mediated fluoroquinolone efflux pump, QepA, found in an Escherichia coli clinical isolate. |
| AID293857 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus ATCC 25923 after 24 hrs by two fold dilution method | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6 | Synthesis of pseudopeptides based L-tryptophan as a potential antimicrobial agent. |
| AID1167361 | Antibacterial activity against wild type Enterococcus faecalis ATCC 29212 after 18 to 24 hrs by two-fold broth microdilution method | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21 | Design, synthesis, and antibacterial properties of dual-ligand inhibitors of acetyl-CoA carboxylase. |
| AID520872 | Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus saprophyticus isolate TSU67 isolated from genitourinary tracts of acute cystitis patient after 24 hrs at 35 degC by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Methicillin-resistant Staphylococcus saprophyticus isolates carrying staphylococcal cassette chromosome mec have emerged in urogenital tract infections. |
| AID1132227 | Antibacterial activity against Staphylococcus aureus 210 assessed as growth inhibition by agar dilution method | 1978 | Journal of medicinal chemistry, Feb, Volume: 21, Issue:2 | Chemical modification of 1,4-diamino-1,4-dideoxy-3-O-(4-deoxy-4-propionamido-alpha-D-glucopyranosyl)-D-glucitol. |
| AID1455932 | Antifungal activity against Cryptococcus neoformans after 96 hrs by broth micro-dilution method | 2017 | Journal of natural products, 02-24, Volume: 80, Issue:2 | Nabscessins A and B, Aminocyclitol Derivatives from Nocardia abscessus IFM 10029 |
| AID1478534 | Antibacterial activity against Escherichia coli XL1 blue harboring pET9d encode for APH(3')-1a resistance enzyme by double microdilution method | 2017 | Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11 | Covalently linked kanamycin - Ciprofloxacin hybrid antibiotics as a tool to fight bacterial resistance. |
| AID1182140 | Antitubercular activity against Mycobacterium smegmatis by checkerboard assay in presence of 7-hydroxy chlorpromazine | 2014 | Bioorganic & medicinal chemistry, Aug-15, Volume: 22, Issue:16 | Pharmacologically active metabolites, combination screening and target identification-driven drug repositioning in antituberculosis drug discovery. |
| AID501207 | Antimicrobial activity against Escherichia coli 389 assessed as hazy zone of inhibition at 30 ug after 18 hrs by agar diffusion method | 2009 | Journal of natural products, Oct, Volume: 72, Issue:10 | Norselic acids A-E, highly oxidized anti-infective steroids that deter mesograzer predation, from the Antarctic sponge Crella sp. |
| AID1684998 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 assessed as inhibition of bacterial growth incubated for 16 to 20 hrs by microdilution method | 2021 | ACS medicinal chemistry letters, Jan-14, Volume: 12, Issue:1 | Enhancing Antimicrobial Peptide Potency through Multivalent Presentation on Coiled-Coil Nanofibrils. |
| AID544283 | Antimicrobial activity against Enterococcus faecalis NKH13 harboring pMG2200-like and pMG2201-like plasmids after 24 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Isolation of VanB-type Enterococcus faecalis strains from nosocomial infections: first report of the isolation and identification of the pheromone-responsive plasmids pMG2200, Encoding VanB-type vancomycin resistance and a Bac41-type bacteriocin, and pMG2 |
| AID69749 | Antibacterial activity expressed as MIC value was determined on Escherichia coli A-20683 organism | 1986 | Journal of medicinal chemistry, May, Volume: 29, Issue:5 | Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin. |
| AID424613 | Antibacterial activity against kanamycin-resistant and fusidic acid-susceptible Staphylococcus aureus AH287 harboring Ala655Glu mutation in fusA gene after 18 to 24 hrs by Etest strip assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID1079932 | Highest frequency of moderate liver toxicity observed during clinical trials, expressed as a percentage. [column '% BIOL' in source] | |||
| AID1436941 | Antibacterial activity against Staphylococcus aureus ATCC 29213 after 12 hrs | 2017 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 27, Issue:4 | Quinolidene based monocarbonyl curcumin analogues as promising antimycobacterial agents: Synthesis and molecular docking study. |
| AID563513 | Antimicrobial activity against cetylpyridinium chloride-resistant Serratia marcescens 011 harboring plasmid STV28 expressing sdeB gene by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Mutational upregulation of a resistance-nodulation-cell division-type multidrug efflux pump, SdeAB, upon exposure to a biocide, cetylpyridinium chloride, and antibiotic resistance in Serratia marcescens. |
| AID750182 | Antibacterial activity against Staphylococcus aureus ATCC 6538 assessed as growth inhibition after 24 hrs by two-fold serial dilution method | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Synthesis and antimicrobical evaluation of a novel class of 1,3,4-thiadiazole: derivatives bearing 1,2,4-triazolo[1,5-a]pyrimidine moiety. |
| AID1551811 | Antibacterial activity against methicillin-resistant Staphylococcus aureus incubated for 18 hrs post 30 mins pre-diffusion by disk diffusion method | 2019 | European journal of medicinal chemistry, Jul-01, Volume: 173 | Antibacterial activity study of 1,2,4-triazole derivatives. |
| AID575170 | Inhibition of acrAB AcrAB-TolC-mediated Nile Red efflux in Escherichia coli K-12 3-AG100 overexpressing acrAB AcrAB-TolC assessed as time needed for 50% efflux after energization with 50 mM glucose at 200 uM by spectrofluorometric assay | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Optimized Nile Red efflux assay of AcrAB-TolC multidrug efflux system shows competition between substrates. |
| AID424347 | Antibacterial activity against fusidic acid-resistant Staphylococcus aureus AH199 harboring TAA stop codon at nucleotide 241 in rplF gene after 18 to 24 hrs by Etest strip assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID1167352 | Antibacterial activity against wild type Escherichia coli D21 after 18 to 24 hrs by two-fold broth microdilution method | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21 | Design, synthesis, and antibacterial properties of dual-ligand inhibitors of acetyl-CoA carboxylase. |
| AID364062 | Antibacterial activity against Escherichia coli ATCC 35218 after 24 hrs by MTT assay | 2008 | European journal of medicinal chemistry, Sep, Volume: 43, Issue:9 | Enamines as novel antibacterials and their structure-activity relationships. |
| AID278537 | Antimicrobial activity against 60 min 1 M HCl-stressed Bifidobacterium breve ATCC 15700 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID1636356 | Drug activation in human Hep3B cells assessed as human CYP2C9-mediated drug metabolism-induced cytotoxicity measured as decrease in cell viability at 300 uM pre-incubated with BSO for 18 hrs followed by incubation with compound for 3 hrs in presence of NA | 2016 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 26, Issue:16 | Development of a cell viability assay to assess drug metabolite structure-toxicity relationships. |
| AID1890843 | Antimycobacterial activity against Mycobacterium smegmatis mc2 155 harbouring pMyC empty vector assessed as inhibition of mycobacterial growth incubated for 3 to 5 days by resazurin microtiter assay | 2022 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 64 | Design, synthesis and antibacterial activity against pathogenic mycobacteria of conjugated hydroxamic acids, hydrazides and O-alkyl/O-acyl protected hydroxamic derivatives. |
| AID647787 | Antibacterial activity Klebsiella pneumoniae at 40 ug/disc after 24 hrs by agar disc diffusion method | 2012 | European journal of medicinal chemistry, Apr, Volume: 50 | Synthesis of new α aminophosphonate system bearing Indazole moiety and their biological activity. |
| AID1616525 | Antibacterial activity against Staphylococcus aureus ATCC 25923 assessed as growth inhibition at 0.125 mg/m by microbroth dilution method relative to control | 2019 | Journal of natural products, 10-25, Volume: 82, Issue:10 | Polyketides from Marine-Derived |
| AID544272 | Antimicrobial activity against Enterococcus faecalis NKH2 harboring pMG2200-like and pMG2201-like plasmids after 24 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Isolation of VanB-type Enterococcus faecalis strains from nosocomial infections: first report of the isolation and identification of the pheromone-responsive plasmids pMG2200, Encoding VanB-type vancomycin resistance and a Bac41-type bacteriocin, and pMG2 |
| AID1265797 | Antibacterial activity against Enterobacter cloacae ATCC 13047 by microdilution method | 2015 | Journal of medicinal chemistry, Dec-10, Volume: 58, Issue:23 | Synthesis and Bioactivities of Kanamycin B-Derived Cationic Amphiphiles. |
| AID1869561 | Antibacterial activity against Mycobacterium smegmatis DSM 43080 assessed as reduction in bacterial growth measured after 3 days by broth microdilution method | 2022 | Journal of natural products, 06-24, Volume: 85, Issue:6 | Triculamin: An Unusual Lasso Peptide with Potent Antimycobacterial Activity. |
| AID404895 | Antibacterial activity against high-level gentamicin resistant Streptococcus pasteurianus SB10 isolate carrying transposon-borne resistance gene [aac(6')Ie-aph(2'')Ia] by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | High-level gentamicin resistance mediated by a Tn4001-like transposon in seven nonclonal hospital isolates of Streptococcus pasteurianus. |
| AID244900 | In-vitro minimum inhibitory concentration against the growth of Staphylococcus aureus | 2005 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 15, Issue:13 | Synthesis of (1,4)-naphthoquinono-[3,2-c]-1H-pyrazoles and their (1,4)-naphthohydroquinone derivatives as antifungal, antibacterial, and anticancer agents. |
| AID1303882 | Antibacterial activity against multidrug resistant Staphylococcus aureus subsp. aureus Seattle 1945 (ATCC 25923) assessed as reduction in bacterial growth incubated for 6 to 8 hrs | 2016 | Bioorganic & medicinal chemistry letters, 07-01, Volume: 26, Issue:13 | GroEL/ES inhibitors as potential antibiotics. |
| AID378857 | Antimalarial activity against multidrug-resistant Plasmodium falciparum K1 | 2006 | Journal of natural products, Oct, Volume: 69, Issue:10 | Integerrimides A and B, cyclic heptapeptides from the latex of Jatropha integerrima. |
| AID278523 | Antimicrobial activity against Bifidobacterium bifidum ATCC 15696 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID599147 | Antibacterial activity against Escherichia coli after 24 hrs by MTT assay | 2008 | European journal of medicinal chemistry, Mar, Volume: 43, Issue:3 | Synthesis, crystal structure and antimicrobial activity of deoxybenzoin derivatives from genistein. |
| AID732422 | Antimycobacterial activity Mycobacterium tuberculosis H37Rv assessed as growth inhibition measured at day 7 by broth microdilution method | 2013 | ACS medicinal chemistry letters, Jan-10, Volume: 4, Issue:1 | Synthesis and antiplasmodial and antimycobacterial evaluation of new nitroimidazole and nitroimidazooxazine derivatives. |
| AID355266 | Antitubercular activity against Mycobacterium tuberculosis H37Rv after 21 days by broth microdilution method | 1997 | Journal of natural products, Dec, Volume: 60, Issue:12 | Norditerpenoids and diterpenoids from Salvia multicaulis with antituberculous activity. |
| AID1478528 | Antibacterial activity against aminoglycosides-resistant Escherichia coli BL21 harboring pSF815 encode for bifunctional AAC(6')/APH(2\\\\\\\\\\) resistance enzyme by double microdilution method | 2017 | Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11 | Covalently linked kanamycin - Ciprofloxacin hybrid antibiotics as a tool to fight bacterial resistance. |
| AID1738323 | Antibacterial activity against multidrug-resistant Staphylococcus aureus NRS108 assessed as reduction in bacterial growth incubated for 16 to 18 hrs by two-fold serial dilution method | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Capsaicin derivatives with nitrothiophene substituents: Design, synthesis and antibacterial activity against multidrug-resistant S. aureus. |
| AID1413338 | Antifungal activity against Fusarium oxysporum | 2018 | MedChemComm, Jun-01, Volume: 9, Issue:6 | Antifungal amphiphilic kanamycins: new life for an old drug. |
| AID1287415 | Antimycobacterial activity against Mycobacterium bovis BCG after 2 weeks | 2016 | European journal of medicinal chemistry, Apr-13, Volume: 112 | New direct inhibitors of InhA with antimycobacterial activity based on a tetrahydropyran scaffold. |
| AID1562310 | Antimycobacterial activity against Mycobacterium smegmatis atR8 assessed as decrease in drug resistance development at 5 ug/disc after 2 to 3 days by paper disc method | 2019 | European journal of medicinal chemistry, Sep-15, Volume: 178 | Synthesis and antimycobacterial activity of imidazo[1,2-b][1,2,4,5]tetrazines. |
| AID599146 | Antibacterial activity against Bacillus subtilis after 24 hrs by MTT assay | 2008 | European journal of medicinal chemistry, Mar, Volume: 43, Issue:3 | Synthesis, crystal structure and antimicrobial activity of deoxybenzoin derivatives from genistein. |
| AID647789 | Antibacterial activity Salmonella Typhimurium at 40 ug/disc after 24 hrs by agar disc diffusion method | 2012 | European journal of medicinal chemistry, Apr, Volume: 50 | Synthesis of new α aminophosphonate system bearing Indazole moiety and their biological activity. |
| AID584339 | Antibacterial activity against tolC deficient Escherichia coli GD100 presence of 10 mM of glutathione | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics. |
| AID293864 | Antimicrobial activity against Bacillus subtilis after 24 hrs by two fold dilution method | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6 | Synthesis of pseudopeptides based L-tryptophan as a potential antimicrobial agent. |
| AID540931 | Antimicrobial activity against paromomycin-resistant Streptomyces coelicolor SP1 harboring rpsL A262G and C271T mutant gene after 48 hrs | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | A novel insertion mutation in Streptomyces coelicolor ribosomal S12 protein results in paromomycin resistance and antibiotic overproduction. |
| AID424571 | Antibacterial activity against stationary-phase rifampin-resistant Staphylococcus aureus 8325-4 culture assessed as number of viable colonies at 24 ug/ ml after 48 hrs | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID1738322 | Antibacterial activity against mutidrug-resistant Staphylococcus aureus NRS100 assessed as reduction in bacterial growth incubated for 16 to 18 hrs by two fold serial dilution method | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Capsaicin derivatives with nitrothiophene substituents: Design, synthesis and antibacterial activity against multidrug-resistant S. aureus. |
| AID1132237 | Antibacterial activity against drug-sensitive Salmonella 1287 assessed as growth inhibition by agar dilution method | 1978 | Journal of medicinal chemistry, Feb, Volume: 21, Issue:2 | Chemical modification of 1,4-diamino-1,4-dideoxy-3-O-(4-deoxy-4-propionamido-alpha-D-glucopyranosyl)-D-glucitol. |
| AID544277 | Antimicrobial activity against Enterococcus faecalis NKH7 harboring pMG2200-like plasmid after 24 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Isolation of VanB-type Enterococcus faecalis strains from nosocomial infections: first report of the isolation and identification of the pheromone-responsive plasmids pMG2200, Encoding VanB-type vancomycin resistance and a Bac41-type bacteriocin, and pMG2 |
| AID1565709 | Antifungal activity against Candida albicans B-311 incubated for 24 to 36 hrs by two fold dilution method | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Scalable and cost-effective tosylation-mediated synthesis of antifungal and fungal diagnostic 6″-Modified amphiphilic kanamycins. |
| AID1478531 | Antibacterial activity against aminoglycosides-resistant Escherichia coli BL21 harboring pETSACG1 encode for APH(3')-3a resistance enzyme by double microdilution method | 2017 | Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11 | Covalently linked kanamycin - Ciprofloxacin hybrid antibiotics as a tool to fight bacterial resistance. |
| AID162730 | Antibacterial activity expressed as MIC value was determined on Proteus mirabilis A-9900 organism | 1986 | Journal of medicinal chemistry, May, Volume: 29, Issue:5 | Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin. |
| AID424577 | Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH336 (SCV-8) harboring His438Asn mutation in fusA gene after 18 to 24 hrs by Etest strip assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID725075 | Antimicrobial activity against Pseudomonas aeruginosa after 12 to 18 hrs by micro-well dilution method | 2013 | European journal of medicinal chemistry, Jan, Volume: 59 | Synthesis and antibacterial and antifungal evaluation of some chalcone based sulfones and bisulfones. |
| AID575169 | Inhibition of acrAB AcrAB-TolC-mediated Nile Red efflux in Escherichia coli K-12 3-AG100 overexpressing acrAB AcrAB-TolC assessed as time needed for 50% efflux after energization with 50 mM glucose at 1000 uM by spectrofluorometric assay | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Optimized Nile Red efflux assay of AcrAB-TolC multidrug efflux system shows competition between substrates. |
| AID544286 | Antimicrobial activity against Enterococcus faecalis NKH16 harboring pMG2200-like plasmid after 24 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Isolation of VanB-type Enterococcus faecalis strains from nosocomial infections: first report of the isolation and identification of the pheromone-responsive plasmids pMG2200, Encoding VanB-type vancomycin resistance and a Bac41-type bacteriocin, and pMG2 |
| AID1225387 | Antibacterial activity against Escherichia coli AG102 overexpressing AcrAB-TolC by p-iodonitrotetrazolium chloride colorimetric assay | 2015 | Journal of natural products, Mar-27, Volume: 78, Issue:3 | Enhancement of antibiotic activity against multidrug-resistant bacteria by the efflux pump inhibitor 3,4-dibromopyrrole-2,5-dione isolated from a Pseudoalteromonas sp. |
| AID759044 | Antibacterial activity against Escherichia coli assessed as survival after 24 hrs by MTT assay | 2013 | European journal of medicinal chemistry, Jul, Volume: 65 | Potentiating 1-(2-hydroxypropyl)-2-styryl-5-nitroimidazole derivatives against antibacterial agents: design, synthesis and biology analysis. |
| AID532980 | Antibacterial activity against Escherichia coli DH5alpha in presence of 10 mM N-Acetylcysteine | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | N-acetylcysteine-mediated modulation of bacterial antibiotic susceptibility. |
| AID1629133 | Binding affinity to 16S rRNA A-site in Escherichia coli S30 extract assessed as inhibition of translation measured after 30 mins by coupled transcription/translation-based luciferase reporter gene assay | 2016 | Journal of medicinal chemistry, 09-08, Volume: 59, Issue:17 | Effects of 5-O-Ribosylation of Aminoglycosides on Antimicrobial Activity and Selective Perturbation of Bacterial Translation. |
| AID257550 | Antibacterial activity against Streptococcus faecalis | 2005 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 15, Issue:23 | Synthesis and biological evaluation of novel (L)-alpha-amino acid methyl ester, heteroalkyl, and aryl substituted 1,4-naphthoquinone derivatives as antifungal and antibacterial agents. |
| AID1402049 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 after 18 to 20 hrs by spectrophotometry based microdilution method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Synthesis and antimicrobial activity of amino acid and peptide derivatives of mycophenolic acid. |
| AID1230064 | Antibacterial activity against methicillin-resistant Staphylococcus aureus GRE2272 assessed as inhibition of bacterial growth | 2015 | Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13 | Synthesis and antimicrobial activity of chloramphenicol-polyamine conjugates. |
| AID1287399 | Antimicrobial activity against Enterobacter aerogenes after 24 hrs by serial two-fold microbroth dilution method | 2016 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 26, Issue:6 | One-pot synthesis and antimicrobial evaluation of novel 3-cyanopyridine derivatives of (-)-β-pinene. |
| AID569259 | Antimycobacterial activity against Mycobacterium avium subsp. avium ATCC 2529I | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Synthesis and evaluation of anti-tubercular activity of new dithiocarbamate sugar derivatives. |
| AID1303895 | Antibacterial activity against multidrug resistant Pseudomonas aeruginosa NCTC 10332 (ATCC 10145) assessed as reduction in bacterial growth incubated for 6 to 8 hrs | 2016 | Bioorganic & medicinal chemistry letters, 07-01, Volume: 26, Issue:13 | GroEL/ES inhibitors as potential antibiotics. |
| AID749375 | Antimicrobial activity against Staphylococcus aureus ATCC 6538 after 24 hrs by two fold serial dilution method | 2013 | Bioorganic & medicinal chemistry, Jun-01, Volume: 21, Issue:11 | Design, synthesis and antimicrobial activities evaluation of Schiff base derived from secnidazole derivatives as potential FabH inhibitors. |
| AID293867 | Antimicrobial activity against Pseudomonas aeruginosa ATCC 27853 after 24 hrs by two fold dilution method | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6 | Synthesis of pseudopeptides based L-tryptophan as a potential antimicrobial agent. |
| AID144139 | Antibacterial activity against Mycobacterium intracellular. | 1985 | Journal of medicinal chemistry, Dec, Volume: 28, Issue:12 | Synthesis and antibacterial activity of 2,2'-dithiobis(benzamide) derivatives against Mycobacterium species. |
| AID1402053 | Antibacterial activity against ESBL positive Klebsiella pneumoniae ATCC 700603 after 18 to 20 hrs by spectrophotometry based microdilution method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Synthesis and antimicrobial activity of amino acid and peptide derivatives of mycophenolic acid. |
| AID574810 | Antimycobacterial activity against extensively drug-resistant Mycobacterium tuberculosis isolate 2911 horboring rpoB D516V, katG S315T/R463L, gyrA D94G/S95T/R128S/Y129C, rrs A1401G by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Emergence and molecular characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates from the Delhi Region in India. |
| AID381841 | Antibacterial activity against Bacillus subtilis ATCC 6633 | 2008 | Bioorganic & medicinal chemistry, Apr-01, Volume: 16, Issue:7 | Synthesis, structure and antibacterial activity of novel 1-(5-substituted-3-substituted-4,5-dihydropyrazol-1-yl)ethanone oxime ester derivatives. |
| AID1585696 | Antitubercular activity against Mycobacterium tuberculosis H37Rv by microplate alamar blue assay | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Fluoroquinolone-isatin hybrids and their biological activities. |
| AID1740923 | Inhibition of human Cx43 expressed in Escherichia coli LB2003 cells in medium containing 8 mM K+ and 10 uM IPTG by measuring cell growth after 18 hrs by plate reader | 2020 | European journal of medicinal chemistry, Oct-01, Volume: 203 | Amphiphilic aminoglycosides with increased selectivity for inhibition of connexin 43 (Cx43) hemichannels. |
| AID293869 | Antimicrobial activity against Proteus vulgaris CMCC(B) 49001 after 24 hrs by two fold dilution method | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6 | Synthesis of pseudopeptides based L-tryptophan as a potential antimicrobial agent. |
| AID326547 | Antimicrobial activity against Mycobacterium abscessus R65 isolate after 3 to 5 days by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | In Vitro activities of isepamicin, other aminoglycosides, and capreomycin against clinical isolates of rapidly growing mycobacteria in Taiwan. |
| AID68015 | Antibacterial activity expressed as MIC value was determined on Enterobacter cloacae A-20364 organism | 1986 | Journal of medicinal chemistry, May, Volume: 29, Issue:5 | Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin. |
| AID1265789 | Antibacterial activity against Staphylococcus aureus ATCC 29213 by microdilution method | 2015 | Journal of medicinal chemistry, Dec-10, Volume: 58, Issue:23 | Synthesis and Bioactivities of Kanamycin B-Derived Cationic Amphiphiles. |
| AID1617944 | Antibacterial activity against Escherichia coli ATCC 12435 after 16 to 48 hrs | 2019 | Journal of natural products, 12-27, Volume: 82, Issue:12 | Structure Determination, Functional Characterization, and Biosynthetic Implications of Nybomycin Metabolites from a Mining Reclamation Site-Associated |
| AID1265782 | Antibacterial activity against Klebsiella pneumoniae ATCC 27736 by microdilution method | 2015 | Journal of medicinal chemistry, Dec-10, Volume: 58, Issue:23 | Synthesis and Bioactivities of Kanamycin B-Derived Cationic Amphiphiles. |
| AID1132234 | Antibacterial activity against unpigmented Serratia 2840 assessed as growth inhibition by agar dilution method | 1978 | Journal of medicinal chemistry, Feb, Volume: 21, Issue:2 | Chemical modification of 1,4-diamino-1,4-dideoxy-3-O-(4-deoxy-4-propionamido-alpha-D-glucopyranosyl)-D-glucitol. |
| AID278263 | Antimicrobial activity against Salmonella enterica serovar Typhimurium CHS14 tolC::Kan with GyrA D87G mutant | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials. |
| AID544279 | Antimicrobial activity against Enterococcus faecalis NKH9 harboring pMG2200-like and pMG2201-like plasmids after 24 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Isolation of VanB-type Enterococcus faecalis strains from nosocomial infections: first report of the isolation and identification of the pheromone-responsive plasmids pMG2200, Encoding VanB-type vancomycin resistance and a Bac41-type bacteriocin, and pMG2 |
| AID1265795 | Antibacterial activity against vancomycin-resistant Enterococcus by microdilution method | 2015 | Journal of medicinal chemistry, Dec-10, Volume: 58, Issue:23 | Synthesis and Bioactivities of Kanamycin B-Derived Cationic Amphiphiles. |
| AID1359446 | Antibacterial activity against Bacillus subtilis NCIM 2079 after 12 hrs by serial dilution method | 2018 | European journal of medicinal chemistry, May-25, Volume: 152 | Antibacterial and anti-TB tat-peptidomimetics with improved efficacy and half-life. |
| AID1132232 | Antibacterial activity against drug-sensitive Klebsiella 2921 assessed as growth inhibition by agar dilution method | 1978 | Journal of medicinal chemistry, Feb, Volume: 21, Issue:2 | Chemical modification of 1,4-diamino-1,4-dideoxy-3-O-(4-deoxy-4-propionamido-alpha-D-glucopyranosyl)-D-glucitol. |
| AID759042 | Antibacterial activity against Bacillus thuringiensis assessed as survival after 24 hrs by MTT assay | 2013 | European journal of medicinal chemistry, Jul, Volume: 65 | Potentiating 1-(2-hydroxypropyl)-2-styryl-5-nitroimidazole derivatives against antibacterial agents: design, synthesis and biology analysis. |
| AID530051 | Antimicrobial activity against Staphylococcus aureus 286607-R1 harboring wild type gyrB by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Discovery and characterization of QPT-1, the progenitor of a new class of bacterial topoisomerase inhibitors. |
| AID1202745 | Antimicrobial activity against Trichophyton mentagrophytes IFM62679 assessed as reduction in bacterial growth incubated for 48 hrs by microbroth dilution method | 2015 | Journal of natural products, Feb-27, Volume: 78, Issue:2 | Prenylated benzophenones from Triadenum japonicum. |
| AID1866812 | Antifungal activity against Bacillus subtilis assessed as reduction in microbial growth after 24 hrs by two-fold dilution method | 2022 | Journal of natural products, 04-22, Volume: 85, Issue:4 | Secondary Metabolites from |
| AID424568 | Antibacterial activity against fusidic acid-resistant Staphylococcus aureus AH209 harboring deletion of nucleotide 404-427 in rplF gene after 18 to 24 hrs by Etest strip assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID556561 | Antimicrobial activity against sodB gene-deficient Escherichia coli K-12 DKsodB by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Contribution of oxidative damage to antimicrobial lethality. |
| AID534343 | Antimicrobial activity against Burkholderia pseudomallei Bp173 harboring mini-Tn7T after 24 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | The BpeAB-OprB efflux pump of Burkholderia pseudomallei 1026b does not play a role in quorum sensing, virulence factor production, or extrusion of aminoglycosides but is a broad-spectrum drug efflux system. |
| AID1473740 | Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and GSH measured after 10 mins by membrane vesicle transport assay | 2013 | Toxicological sciences : an official journal of the Society of Toxicology, Nov, Volume: 136, Issue:1 | A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. |
| AID163261 | Minimum inhibitory concentration was measured against Pseudomonas aeruginosa A 20357 | 1980 | Journal of medicinal chemistry, Jan, Volume: 23, Issue:1 | Aminoglycoside antibiotics. 3. Epimino derivatives of neamine, ribostamycin, and kanamycin B. |
| AID1167360 | Antibacterial activity against wild type Staphylococcus epidermidis ATCC 35984 after 18 to 24 hrs by two-fold broth microdilution method | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21 | Design, synthesis, and antibacterial properties of dual-ligand inhibitors of acetyl-CoA carboxylase. |
| AID524265 | Antibacterial activity against Escherichia coli NKE159 harboring deletion mutation in acrB, cpxAR protein and plasmid expressing nlpE gene | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Effect of NlpE overproduction on multidrug resistance in Escherichia coli. |
| AID540928 | Antimicrobial activity against streptomycin-resistant Streptomyces coelicolor KO-178 harboring rpsL K88E mutant gene after 48 hrs | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | A novel insertion mutation in Streptomyces coelicolor ribosomal S12 protein results in paromomycin resistance and antibiotic overproduction. |
| AID524266 | Antibacterial activity against Escherichia coli NKE128 harboring deletion mutation in acrB and tolC protein | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Effect of NlpE overproduction on multidrug resistance in Escherichia coli. |
| AID278245 | Antimicrobial activity against Salmonella enterica serovar Typhimurium S21-4 gyrA+ with ParC S80I mutation | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials. |
| AID532984 | Antibacterial activity against Escherichia coli MG1655 in presence of 10 mM N-Acetylcysteine | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | N-acetylcysteine-mediated modulation of bacterial antibiotic susceptibility. |
| AID1710565 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 1960649 assessed as reduction in bacterial growth incubated for 15 to 20 hrs by broth microdilution method | 2018 | MedChemComm, Jul-01, Volume: 9, Issue:7 | Targeting miRNA by tunable small molecule binders: peptidic aminosugar mediated interference in miR-21 biogenesis reverts epithelial to mesenchymal transition. |
| AID1056538 | Antibacterial activity against Aeromonas hydrophila ATCC 7966 by broth microdilution method | 2013 | Journal of natural products, Dec-27, Volume: 76, Issue:12 | Cytotoxic and antibacterial marfuraquinocins from the deep South China Sea-derived Streptomyces niveus SCSIO 3406. |
| AID551744 | Antibacterial activity against Mycobacterium smegmatis ATCC 14468 after 12 to 18 hrs by twofold dilution method | 2011 | Bioorganic & medicinal chemistry, Jan-01, Volume: 19, Issue:1 | Synthesis and antibacterial activity study of a novel class of cationic anthraquinone analogs. |
| AID342023 | Antibacterial activity against Escherichia coli J53 by broth microdilution test | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Sequencing and comparative genomic analysis of pK29, a 269-kilobase conjugative plasmid encoding CMY-8 and CTX-M-3 beta-lactamases in Klebsiella pneumoniae. |
| AID207040 | Antibacterial activity expressed as MIC value was determined on Staphylococcus aureus A-22058 organism | 1986 | Journal of medicinal chemistry, May, Volume: 29, Issue:5 | Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin. |
| AID1478535 | Ratio of MIC for Escherichia coli XL1 blue harboring pET9d encode for APH(3')-1a resistance enzyme to MIC for Escherichia coli XL1 blue | 2017 | Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11 | Covalently linked kanamycin - Ciprofloxacin hybrid antibiotics as a tool to fight bacterial resistance. |
| AID424576 | Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH334 (SCV-6) harboring Thr436Ile mutation in fusA gene after 18 to 24 hrs by Etest strip assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID1079946 | Presence of at least one case with successful reintroduction. [column 'REINT' in source] | |||
| AID278560 | Antimicrobial activity against 90 mins hydrogen peroxide-stressed Bifidobacterium bifidum BB12 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID381178 | Antibacterial activity against Pseudomonas aeruginosa after 24 to 72 hrs by disk diffusion method | 1999 | Journal of natural products, Sep, Volume: 62, Issue:9 | Antimicrobial and antitumor activities of mycosporulone. |
| AID750183 | Antibacterial activity against Bacillus subtilis ATCC 6633 assessed as growth inhibition after 24 hrs by two-fold serial dilution method | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Synthesis and antimicrobical evaluation of a novel class of 1,3,4-thiadiazole: derivatives bearing 1,2,4-triazolo[1,5-a]pyrimidine moiety. |
| AID560250 | Antibacterial activity against Staphylococcus aureus RN4220 harboring aadD and tet(L) gene by CLSI method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Novel ABC transporter gene, vga(C), located on a multiresistance plasmid from a porcine methicillin-resistant Staphylococcus aureus ST398 strain. |
| AID1565710 | Antifungal activity against Candida rugosa 95-967 incubated for 24 to 36 hrs by two fold dilution method | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Scalable and cost-effective tosylation-mediated synthesis of antifungal and fungal diagnostic 6″-Modified amphiphilic kanamycins. |
| AID574797 | Antimycobacterial activity against extensively drug-resistant Mycobacterium tuberculosis isolate 2911 obtained from sputum of patient at 4 ug/ml by Bactec MGIT960 modified proportion method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Emergence and molecular characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates from the Delhi Region in India. |
| AID574811 | Antimycobacterial activity against extensively drug-resistant Mycobacterium tuberculosis H37Rv by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Emergence and molecular characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates from the Delhi Region in India. |
| AID556756 | Bactericidal activity against ahpC gene-deficient Escherichia coli K-12 3200 after 18 hrs | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Contribution of oxidative damage to antimicrobial lethality. |
| AID283547 | Antibacterial activity against Pseudomonas aeruginosa FE60 containing inactivated mexXY gene by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides. |
| AID424879 | Antimicrobial activity against multidrug-resistant Enterobacter cloacae E705 bearing qnrB10 gene with aac(6)-IId-aadA1a integron in presence of IPTG | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Complex class 1 integrons with diverse variable regions, including aac(6')-Ib-cr, and a novel allele, qnrB10, associated with ISCR1 in clinical enterobacterial isolates from Argentina. |
| AID771496 | Antibacterial activity against Acinetobacter baumannii by dilution technique | 2013 | European journal of medicinal chemistry, Oct, Volume: 68 | Synthesis and biological evaluation of novel ocotillol-type triterpenoid derivatives as antibacterial agents. |
| AID1562313 | Antimycobacterial activity against Mycobacterium smegmatis atR17 assessed as decrease in drug resistance development at 5 ug/disc after 2 to 3 days by paper disc method | 2019 | European journal of medicinal chemistry, Sep-15, Volume: 178 | Synthesis and antimycobacterial activity of imidazo[1,2-b][1,2,4,5]tetrazines. |
| AID1348088 | Antimicrobial activity against Pseudomonas aeruginosa ATCC 27853 assessed as zone of inhibition at 50 ug per disc after 24 hrs by disc diffusion assay | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Synthesis of new 1-benzyl tetrahydropyridinylidene ammonium salts and their antimicrobial and anticellular activities. |
| AID326548 | Antimicrobial activity against Mycobacterium abscessus R53 isolate after 3 to 5 days by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | In Vitro activities of isepamicin, other aminoglycosides, and capreomycin against clinical isolates of rapidly growing mycobacteria in Taiwan. |
| AID582764 | Antimicrobial activity against eaeA negative verocytotoxin-producing non-O157 Escherichia coli isolates obtained from human assessed as percentage of resistant isolates | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Antimicrobial resistance testing of verocytotoxin-producing Escherichia coli and first description of TEM-52 extended-spectrum β-lactamase in serogroup O26. |
| AID278254 | Antimicrobial activity against Salmonella enterica serovar Typhimurium CS3 acrAB::Kan with GyrA S83F, D87N, ParC S80I mutation | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials. |
| AID1105382 | Antibacterial activity against Xanthomonas oryzae ITCC B-47 assessed as as growth inhibition at 25 ug/disk after 24 hr by disk diffusion method | 2013 | European journal of medicinal chemistry, Jan, Volume: 59 | Microwave synthesis, characterization and bio-efficacy evaluation of novel chalcone based 6-carbethoxy-2-cyclohexen-1-one and 2H-indazol-3-ol derivatives. |
| AID381842 | Antibacterial activity against Escherichia coli ATCC 35218 | 2008 | Bioorganic & medicinal chemistry, Apr-01, Volume: 16, Issue:7 | Synthesis, structure and antibacterial activity of novel 1-(5-substituted-3-substituted-4,5-dihydropyrazol-1-yl)ethanone oxime ester derivatives. |
| AID670725 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 24 hrs by MTT assay | 2012 | Bioorganic & medicinal chemistry, Jul-15, Volume: 20, Issue:14 | Design, synthesis and antimicrobial activities of nitroimidazole derivatives containing 1,3,4-oxadiazole scaffold as FabH inhibitors. |
| AID521594 | Antibacterial activity against Salmonella enterica serovars virchow isolate 101591 at pH 5.7 by bioluminescence assay | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Aminoglycosides affect intracellular Salmonella enterica serovars typhimurium and virchow. |
| AID1332980 | Antitubercular activity against Mycobacterium tuberculosis H37Rv | 2016 | European journal of medicinal chemistry, Nov-10, Volume: 123 | Synthesis and biological activity of furoxan derivatives against Mycobacterium tuberculosis. |
| AID524262 | Antibacterial activity against Escherichia coli NKE155 harboring deletion mutation in acrB protein and plasmid expressing nlpE gene | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Effect of NlpE overproduction on multidrug resistance in Escherichia coli. |
| AID740233 | Antibacterial activity against Staphylococcus aureus ATCC 530 assessed as growth inhibition after 24 hrs by MTT assay | 2013 | Bioorganic & medicinal chemistry, Apr-15, Volume: 21, Issue:8 | Novel 1,3,4-oxadiazole thioether derivatives targeting thymidylate synthase as dual anticancer/antimicrobial agents. |
| AID523397 | Antimicrobial activity against amikacin-susceptible Nocardia farcinica IFM 10152 harboring 16s rRNA A1408G mutant after 3 days by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Homozygous triplicate mutations in three 16S rRNA genes responsible for high-level aminoglycoside resistance in Nocardia farcinica clinical isolates from a Canada-wide bovine mastitis epizootic. |
| AID1263043 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 at 1 mM after 24 to 48 hrs by Kirby-Bauer disc diffusion susceptibility test | 2015 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 25, Issue:24 | Synthesis and biological evaluation of pyrazolopyrimidines as potential antibacterial agents. |
| AID1624154 | Antitubercular activity against multidrug-resistant Mycobacterium tuberculosis isolate 6 after 7 days | 2019 | European journal of medicinal chemistry, Feb-15, Volume: 164 | Synthesis and evaluation of α-aminoacyl amides as antitubercular agents effective on drug resistant tuberculosis. |
| AID424603 | Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH360 (SCV-32) harboring ATA start codon at nucleotide 3 in rplF gene after 18 to 24 hrs by Etest strip assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID584122 | Antimicrobial activity against Staphylococcus aureus RN4220 by CLSI M31-A3 method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Novel apramycin resistance gene apmA in bovine and porcine methicillin-resistant Staphylococcus aureus ST398 isolates. |
| AID1593371 | Inhibition of Pks13 D1644G/N1640K double mutant thioesterase domain in Mycobacterium tuberculosis H37Rv assessed as reduction in bacterial growth by microplate alamar blue assay | 2019 | Journal of medicinal chemistry, 04-11, Volume: 62, Issue:7 | Identification of Novel Coumestan Derivatives as Polyketide Synthase 13 Inhibitors against Mycobacterium tuberculosis. Part II. |
| AID625924 | Antibacterial activity against Klebsiella pneumoniae ATCC 27736 by micro-broth dilution method | 2011 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 21, Issue:21 | Micelles catalyzed chemoselective synthesis 'in water' and biological evaluation of oxygen containing hetero-1,4-naphthoquinones as potential antifungal agents. |
| AID530052 | Antimicrobial activity against Staphylococcus aureus RN4220 expressing gyrB D437N mutant gene by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Discovery and characterization of QPT-1, the progenitor of a new class of bacterial topoisomerase inhibitors. |
| AID424341 | Antibacterial activity against fusidic acid-resistant Staphylococcus aureus AH197 harboring Leu456Phe mutation in fusA gene after 18 to 24 hrs by Etest strip assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID556567 | Antimicrobial activity against katG,katE gene-deficient Escherichia coli K-12 3201 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Contribution of oxidative damage to antimicrobial lethality. |
| AID1348082 | Antimicrobial activity against Candida tropicalis ATCC 13803 assessed as zone of inhibition at 50 ug per disc after 48 hrs by disc diffusion assay | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Synthesis of new 1-benzyl tetrahydropyridinylidene ammonium salts and their antimicrobial and anticellular activities. |
| AID405082 | Antimicrobial activity against Escherichia coli 33587-TC9 by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Biochemical characterization of PER-2 and genetic environment of blaPER-2. |
| AID283656 | Increase in ROS levels in Escherichia coli K12 MG1655 assessed as ratio of ROS with antibiotic to ROS without antibiotic | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Effects of glutathione and ascorbic acid on streptomycin sensitivity of Escherichia coli. |
| AID278533 | Antimicrobial activity against Bifidobacterium breve R0070 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID278530 | Antimicrobial activity against Bifidobacterium longum P/N 601377 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID1629122 | Antimicrobial activity against Pseudomonas aeruginosa ATCC 47085 measured after 24 hrs by double-dilution method | 2016 | Journal of medicinal chemistry, 09-08, Volume: 59, Issue:17 | Effects of 5-O-Ribosylation of Aminoglycosides on Antimicrobial Activity and Selective Perturbation of Bacterial Translation. |
| AID404901 | Antibacterial activity against high-level gentamicin resistant Streptococcus pasteurianus SB41 isolate carrying transposon-borne resistance gene [aac(6')Ie-aph(2'')Ia] by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | High-level gentamicin resistance mediated by a Tn4001-like transposon in seven nonclonal hospital isolates of Streptococcus pasteurianus. |
| AID1730995 | Antitubercular activity against extensively drug resistance Mycobacterium tuberculosis R506 XDR by MABA | 2021 | European journal of medicinal chemistry, Mar-05, Volume: 213 | Design and synthesis of mycobacterial pks13 inhibitors: Conformationally rigid tetracyclic molecules. |
| AID299661 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus ATCC 25923 by broth microdilution method | 2007 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 17, Issue:15 | Synthesis and evaluation of amphiphilic cationic quinine-derived for antibacterial activity against methicillin-resistant Staphylococcus aureus. |
| AID1695860 | Antibacterial activity against Micrococcus Luteus ATCC 398 incubated for 24 hrs | 2019 | European journal of medicinal chemistry, Apr-15, Volume: 168 | Comprehensive review on the anti-bacterial activity of 1,2,3-triazole hybrids. |
| AID551747 | Antibacterial activity against Klebsiella pneumoniae ATCC 13883 after 12 to 18 hrs by twofold dilution method | 2011 | Bioorganic & medicinal chemistry, Jan-01, Volume: 19, Issue:1 | Synthesis and antibacterial activity study of a novel class of cationic anthraquinone analogs. |
| AID563505 | Antimicrobial activity against cetylpyridinium chloride-resistant Serratia marcescens 01 harboring plasmid STV29 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Mutational upregulation of a resistance-nodulation-cell division-type multidrug efflux pump, SdeAB, upon exposure to a biocide, cetylpyridinium chloride, and antibiotic resistance in Serratia marcescens. |
| AID1077161 | Inhibition of Pseudomonas aeruginosa FabH after 25 mins | 2014 | European journal of medicinal chemistry, Apr-09, Volume: 76 | Design and synthesis of 2-styryl of 5-Nitroimidazole derivatives and antimicrobial activities as FabH inhibitors. |
| AID285338 | Antimicrobial activity against streptomycin-resistant Escherichia coli J53 transconjugant with qnrA1 producing urinary specimen isolate 13.52 by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | First report of plasmid-mediated qnrA1 in a ciprofloxacin-resistant Escherichia coli strain in Latin America. |
| AID551746 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 12 to 18 hrs by twofold dilution method | 2011 | Bioorganic & medicinal chemistry, Jan-01, Volume: 19, Issue:1 | Synthesis and antibacterial activity study of a novel class of cationic anthraquinone analogs. |
| AID486970 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 24 hrs by micro broth dilution method | 2010 | European journal of medicinal chemistry, Jun, Volume: 45, Issue:6 | 'On water' assisted synthesis and biological evaluation of nitrogen and sulfur containing hetero-1,4-naphthoquinones as potent antifungal and antibacterial agents. |
| AID278559 | Antimicrobial activity against 90 mins hydrogen peroxide-stressed Bifidobacterium bifidum R0071 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID625923 | Antibacterial activity against Staphylococcus aureus ATCC 25923 by micro-broth dilution method | 2011 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 21, Issue:21 | Micelles catalyzed chemoselective synthesis 'in water' and biological evaluation of oxygen containing hetero-1,4-naphthoquinones as potential antifungal agents. |
| AID424580 | Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH332 (SCV-4) harboring Ala655Glu mutation in fusA gene after 18 to 24 hrs by Etest strip assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID460285 | Antibacterial activity against aminoglycoside-susceptible Escherichia coli ATCC 25922 after 12 to 18 hrs | 2010 | Bioorganic & medicinal chemistry, Feb-15, Volume: 18, Issue:4 | Synthesis of novel aminoglycosides via allylic azide rearrangement for investigating the significance of 2'-amino group. |
| AID404899 | Antibacterial activity against high-level gentamicin resistant Streptococcus pasteurianus SB34 isolate carrying transposon-borne resistance gene [aac(6')Ie-aph(2'')Ia] by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | High-level gentamicin resistance mediated by a Tn4001-like transposon in seven nonclonal hospital isolates of Streptococcus pasteurianus. |
| AID278269 | Antimicrobial activity against Salmonella enterica serovar Typhimurium CHS38 gyrA+ with GyrA D87G mutation | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials. |
| AID158615 | IC50 was measured as concentration causing 50% inhibition of lysosomal phospholipase A1 activity. | 1995 | Journal of medicinal chemistry, Nov-10, Volume: 38, Issue:23 | Synthesis and antimicrobial and toxicological studies of amino acid and peptide derivatives of kanamycin A and netilmicin. |
| AID574791 | Antimycobacterial activity against extensively drug-resistant Mycobacterium tuberculosis isolate 2301 obtained from sputum of patient at 4 ug/ml by Bactec MGIT960 modified proportion method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Emergence and molecular characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates from the Delhi Region in India. |
| AID573966 | Antibacterial activity against Cj1211-positive Campylobacter jejuni harboring aphA3 and tet(O) genes | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Role of Cj1211 in natural transformation and transfer of antibiotic resistance determinants in Campylobacter jejuni. |
| AID283538 | Antibacterial activity against Pseudomonas aeruginosa FE53G with inactivated mexZ and nuoG genes by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides. |
| AID1905609 | Induction of drug resistance in Escherichia coli ATCC 25922 assessed as increase in MIC measured after 20 passages by CLSI protocol based broth microdilution method | 2022 | Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7 | Novel β-Hairpin Antimicrobial Peptides Containing the β-Turn Sequence of -RRRF- Having High Cell Selectivity and Low Incidence of Drug Resistance. |
| AID283542 | Antibacterial activity against Pseudomonas aeruginosa FE57GU with inactivated rplY, nuoG and galU genes by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides. |
| AID102513 | In vitro inhibition of translation in luciferase SP6 control plasmid | 2002 | Journal of medicinal chemistry, Aug-01, Volume: 45, Issue:16 | New inhibitors of bacterial protein synthesis from a combinatorial library of macrocycles. |
| AID574808 | Antimycobacterial activity against extensively drug-resistant Mycobacterium tuberculosis isolate 2301 horboring rpoB S531L, katG R463L/E217G, gyrA D94N/S95T, rrs A1401G by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Emergence and molecular characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates from the Delhi Region in India. |
| AID1413323 | Antibacterial activity against Micrococcus luteus ATCC 10240 | 2018 | MedChemComm, Jun-01, Volume: 9, Issue:6 | Antifungal amphiphilic kanamycins: new life for an old drug. |
| AID283646 | Susceptibility of Escherichia coli K12 MG1655 by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Effects of glutathione and ascorbic acid on streptomycin sensitivity of Escherichia coli. |
| AID1731000 | Antibacterial activity against Escherichia coli AB1157 assessed as inhibition of bacterial growth measured after 18 hrs by two fold serial dilution method | 2021 | European journal of medicinal chemistry, Mar-05, Volume: 213 | Design and synthesis of mycobacterial pks13 inhibitors: Conformationally rigid tetracyclic molecules. |
| AID1905564 | Antimicrobial activity against Enterococcus faecalis ATCC 29212 assessed as reduction of bacterial growth incubated for 18 hrs by CLSI protocol based broth microdilution method | 2022 | Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7 | Novel β-Hairpin Antimicrobial Peptides Containing the β-Turn Sequence of -RRRF- Having High Cell Selectivity and Low Incidence of Drug Resistance. |
| AID1167359 | Antibacterial activity against Staphylococcus aureus ATCC 29213 expressing norA after 18 to 24 hrs by two-fold broth microdilution method | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21 | Design, synthesis, and antibacterial properties of dual-ligand inhibitors of acetyl-CoA carboxylase. |
| AID1359444 | Antibacterial activity against Pseudomonas aeruginosa NCIM 2036 after 8 hrs by serial dilution method | 2018 | European journal of medicinal chemistry, May-25, Volume: 152 | Antibacterial and anti-TB tat-peptidomimetics with improved efficacy and half-life. |
| AID206394 | Compound was tested for photoinhibition of Staphylococcus aureus(CIP 53156); Sensitive | 1998 | Bioorganic & medicinal chemistry letters, Nov-03, Volume: 8, Issue:21 | Nitroglycosylated meso-arylporphyrins as photoinhibitors of gram positive bacteria. |
| AID1348085 | Antimicrobial activity against Klebsiella oxytoca ATCC 8724 assessed as zone of inhibition at 50 ug per disc after 24 hrs by disc diffusion assay | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Synthesis of new 1-benzyl tetrahydropyridinylidene ammonium salts and their antimicrobial and anticellular activities. |
| AID625282 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cirrhosis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID1077167 | Antibacterial activity against Bacillus thuringiensis after 12 hrs by MTT assay | 2014 | European journal of medicinal chemistry, Apr-09, Volume: 76 | Design and synthesis of 2-styryl of 5-Nitroimidazole derivatives and antimicrobial activities as FabH inhibitors. |
| AID381181 | Antibacterial activity against Streptococcus faecalis after 24 to 72 hrs by disk diffusion method | 1999 | Journal of natural products, Sep, Volume: 62, Issue:9 | Antimicrobial and antitumor activities of mycosporulone. |
| AID524261 | Antibacterial activity against Escherichia coli NKE154 harboring vector expressing acrB deletion mutant | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Effect of NlpE overproduction on multidrug resistance in Escherichia coli. |
| AID1866814 | Antifungal activity against Staphylococcus aureus assessed as reduction in microbial growth after 24 hrs by two-fold dilution method | 2022 | Journal of natural products, 04-22, Volume: 85, Issue:4 | Secondary Metabolites from |
| AID625278 | FDA Liver Toxicity Knowledge Base Benchmark Dataset (LTKB-BD) drugs of no concern for DILI | 2011 | Drug discovery today, Aug, Volume: 16, Issue:15-16 | FDA-approved drug labeling for the study of drug-induced liver injury. |
| AID283549 | Antibacterial activity against Pseudomonas aeruginosa FE64 containing inactivated rplY and mexXY genes by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides. |
| AID278527 | Antimicrobial activity against Bifidobacterium longum ATCC 15707 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID521597 | Antibacterial activity against Salmonella enterica serovars Typhimurium ATCC 14028 at pH 5.7 by bioluminescence assay | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Aminoglycosides affect intracellular Salmonella enterica serovars typhimurium and virchow. |
| AID1271383 | Antimicrobial activity against Gram-negative Haemophilus influenzae ATCC 51907 after 16 to 24 hrs by micro-dilution method | 2015 | ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11 | Synthesis and Biological Activity of Mono- and Di-N-acylated Aminoglycosides. |
| AID424824 | Antibacterial activity against kanamycin-resistant and fusidic acid-susceptible Staphylococcus aureus AH296 harboring Gly664Ala mutation in fusA gene after 18 to 24 hrs by Etest strip assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID1624149 | Antitubercular activity against isoniazid/ethionamide resistant Mycobacterium tuberculosis isolate 1 after 7 days | 2019 | European journal of medicinal chemistry, Feb-15, Volume: 164 | Synthesis and evaluation of α-aminoacyl amides as antitubercular agents effective on drug resistant tuberculosis. |
| AID1585462 | Antibacterial activity against oxacillin/tetracycline-resistant Staphylococcus aureus NRS-100 measured after 16 hrs | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Design, synthesis and evaluation of hybrid of tetrahydrocarbazole with 2,4-diaminopyrimidine scaffold as antibacterial agents. |
| AID1869559 | Antibacterial activity against Mycobacterium phlei DSM 43239 assessed as reduction in bacterial growth measured after 3 days by broth microdilution method | 2022 | Journal of natural products, 06-24, Volume: 85, Issue:6 | Triculamin: An Unusual Lasso Peptide with Potent Antimycobacterial Activity. |
| AID290145 | Antibacterial activity against Escherichia coli after 24 hrs by MTT colorimetric method | 2007 | European journal of medicinal chemistry, Apr, Volume: 42, Issue:4 | Synthesis and antimicrobial activities of Schiff bases derived from 5-chloro-salicylaldehyde. |
| AID563502 | Antimicrobial activity against cetylpyridinium chloride-sensitive Serratia marcescens 71 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Mutational upregulation of a resistance-nodulation-cell division-type multidrug efflux pump, SdeAB, upon exposure to a biocide, cetylpyridinium chloride, and antibiotic resistance in Serratia marcescens. |
| AID1182141 | Antitubercular activity against Mycobacterium smegmatis by checkerboard assay in presence of chlorpromazine-N-oxide | 2014 | Bioorganic & medicinal chemistry, Aug-15, Volume: 22, Issue:16 | Pharmacologically active metabolites, combination screening and target identification-driven drug repositioning in antituberculosis drug discovery. |
| AID278536 | Antimicrobial activity against 60 min 1 M HCl-stressed Bifidobacterium bifidum BB12 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID1765575 | Antibacterial activity against Enterococcus faecalis ATCC 29212 incubated for 18 hrs by CLSI based broth dilution method | 2021 | Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15 | Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice. |
| AID535770 | Antimicrobial activity against Mycobacterium ulcerans Cu001 agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Rapid assessment of antibacterial activity against Mycobacterium ulcerans by using recombinant luminescent strains. |
| AID1079947 | Comments (NB not yet translated). [column 'COMMENTAIRES' in source] | |||
| AID278233 | Antimicrobial activity against Salmonella enterica serovar Typhimurium S21-1 gyrA+ | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials. |
| AID544284 | Antimicrobial activity against Enterococcus faecalis NKH14 harboring pMG2200-like and pMG2201-like plasmids after 24 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Isolation of VanB-type Enterococcus faecalis strains from nosocomial infections: first report of the isolation and identification of the pheromone-responsive plasmids pMG2200, Encoding VanB-type vancomycin resistance and a Bac41-type bacteriocin, and pMG2 |
| AID510750 | Antibacterial activity against Escherichia coli AG102MB harboring pS1328-based acrB gene | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Single nucleotide polymorphism analysis of the major tripartite multidrug efflux pump of Escherichia coli: functional conservation in disparate animal reservoirs despite exposure to antimicrobial chemotherapy. |
| AID278545 | Antimicrobial activity against 90 mins oxgall-stressed Bifidobacterium animalis ATCC 27536 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID1182138 | Antitubercular activity against Mycobacterium smegmatis assessed as reduction in MIC99 by checkerboard assay in presence of chlorpromazine-N-S-dioxide relative to control | 2014 | Bioorganic & medicinal chemistry, Aug-15, Volume: 22, Issue:16 | Pharmacologically active metabolites, combination screening and target identification-driven drug repositioning in antituberculosis drug discovery. |
| AID1594068 | Antibacterial activity against Escherichia coli assessed as reduction in bacterial cell viability incubated for 20 to 24 hrs by REMA method | 2019 | Bioorganic & medicinal chemistry, 06-15, Volume: 27, Issue:12 | Design, synthesis, in-silico studies and biological screening of quinazolinone analogues as potential antibacterial agents against MRSA. |
| AID718272 | Antimicrobial activity against Bacillus thuringiensis | 2012 | Journal of natural products, Dec-28, Volume: 75, Issue:12 | Marthiapeptide A, an anti-infective and cytotoxic polythiazole cyclopeptide from a 60 L scale fermentation of the deep sea-derived Marinactinospora thermotolerans SCSIO 00652. |
| AID325448 | Antibacterial activity against Staphylococcus aureus Mu50 after 14 to 16 hrs by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Polyamine effects on antibiotic susceptibility in bacteria. |
| AID532027 | Antimicrobial activity against Kluyvera georgiana 14751 expressing beta-lactamase CTX-M-78 obtained from bloodstream of patient by disk diffusion method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Novel chromosome-encoded CTX-M-78 beta-lactamase from a Kluyvera georgiana clinical isolate as a putative origin of CTX-M-25 subgroup. |
| AID524391 | Antibacterial activity against Escherichia coli NKE1368 harboring deletion mutation in acrB, acrD and vector expressing mdtABC gene | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Effect of NlpE overproduction on multidrug resistance in Escherichia coli. |
| AID1230065 | Antibacterial activity against methicillin-resistant Staphylococcus aureus GRE2372 assessed as inhibition of bacterial growth | 2015 | Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13 | Synthesis and antimicrobial activity of chloramphenicol-polyamine conjugates. |
| AID424593 | Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH379 (SCV-51) harboring TAA stop codon at nucleotide 418 in rplF but gene after 18 to 24 hrs by Etest strip assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID556590 | Bactericidal activity against sodB gene-deficient Escherichia coli K-12 DK after 18 hrs | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Contribution of oxidative damage to antimicrobial lethality. |
| AID1905567 | Antimicrobial activity against Pseudomonas aeruginosa ATCC 27853 assessed as reduction of bacterial growth incubated for 18 hrs by CLSI protocol based broth microdilution method | 2022 | Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7 | Novel β-Hairpin Antimicrobial Peptides Containing the β-Turn Sequence of -RRRF- Having High Cell Selectivity and Low Incidence of Drug Resistance. |
| AID501184 | Antimicrobial activity against Candida albicans 54 at 30 ug after 18 hrs by agar diffusion method | 2009 | Journal of natural products, Oct, Volume: 72, Issue:10 | Norselic acids A-E, highly oxidized anti-infective steroids that deter mesograzer predation, from the Antarctic sponge Crella sp. |
| AID1262358 | Antibacterial activity against clinical isolates Escherichia coli after 24 hrs by agar diffusion assay | 2015 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 25, Issue:24 | PPL catalyzed four-component PASE synthesis of 5-monosubstituted barbiturates: Structure and pharmacological properties. |
| AID774293 | Cytotoxicity against african green monkey Vero cells after 72 hrs by MTS-PMS assay | 2013 | Journal of natural products, Oct-25, Volume: 76, Issue:10 | Chlorinated coumarins from the polypore mushroom Fomitopsis officinalis and their activity against Mycobacterium tuberculosis. |
| AID1565711 | Antifungal activity against azole-resistant Candida parapsilosis Cas08-0490 incubated for 24 to 36 hrs by two fold dilution method | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Scalable and cost-effective tosylation-mediated synthesis of antifungal and fungal diagnostic 6″-Modified amphiphilic kanamycins. |
| AID1868106 | Antibacterial activity against methicillin-resistant Staphylococcus aureus clinical isolate 9B assessed as inhibition of visible bacterial growth incubated for 18 hrs by CLSI protocol based assay | 2022 | Journal of natural products, 05-27, Volume: 85, Issue:5 | Enceleamycins A-C, Furo-Naphthoquinones from |
| AID1629135 | Selectivity ratio, ratio of IC50 for cytosolic eukaryotic translation in rabbit reticulocyte S30 extract to IC50 for 16S rRNA A-site in Escherichia coli S30 extract | 2016 | Journal of medicinal chemistry, 09-08, Volume: 59, Issue:17 | Effects of 5-O-Ribosylation of Aminoglycosides on Antimicrobial Activity and Selective Perturbation of Bacterial Translation. |
| AID1167358 | Antibacterial activity against moiramide-resistant Staphylococcus aureus ATCC 29213 after 18 to 24 hrs by two-fold broth microdilution method | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21 | Design, synthesis, and antibacterial properties of dual-ligand inhibitors of acetyl-CoA carboxylase. |
| AID1869575 | Antibacterial activity against Enterobacter cloacae DSM 30054 assessed as reduction in bacterial growth measured after 3 days by broth microdilution method | 2022 | Journal of natural products, 06-24, Volume: 85, Issue:6 | Triculamin: An Unusual Lasso Peptide with Potent Antimycobacterial Activity. |
| AID285337 | Antimicrobial activity against Escherichia coli qnrA1 producing urinary specimen isolate 13.52 by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | First report of plasmid-mediated qnrA1 in a ciprofloxacin-resistant Escherichia coli strain in Latin America. |
| AID1478540 | Resistance index, ratio of MIC for Bacillus subtilis ATCC 6633 in 15th subculture to MIC for Bacillus subtilis ATCC 6633 in first subculture | 2017 | Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11 | Covalently linked kanamycin - Ciprofloxacin hybrid antibiotics as a tool to fight bacterial resistance. |
| AID683685 | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 after 7 days by microplate alamar blue assay | 2012 | European journal of medicinal chemistry, Nov, Volume: 57 | The design, synthesis, in silico ADME profiling, antiplasmodial and antimycobacterial evaluation of new arylamino quinoline derivatives. |
| AID69755 | Antibacterial activity expressed as MIC value was determined on Escherichia coli A-22045 organism | 1986 | Journal of medicinal chemistry, May, Volume: 29, Issue:5 | Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin. |
| AID524386 | Antibacterial activity against Escherichia coli NKE157 harboring deletion mutation in acrB, acrD protein and plasmid expressing nlpE gene | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Effect of NlpE overproduction on multidrug resistance in Escherichia coli. |
| AID540210 | Clearance in human after iv administration | 2008 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7 | Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. |
| AID560591 | Antimicrobial activity against Pseudomonas aeruginosa isolate IMCJ799 by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | AAC(6')-Iaf, a novel aminoglycoside 6'-N-acetyltransferase from multidrug-resistant Pseudomonas aeruginosa clinical isolates. |
| AID424586 | Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH352 (SCV-24) harboring -1 frameshift mutation at nucleotide 106 in rplF gene after 18 to 24 hrs by Etest strip assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID424579 | Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH340 (SCV-12) harboring Gly617Asp mutation in fusA gene after 18 to 24 hrs by Etest strip assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID126452 | Dissociation constant for binding to mitochondrial 12S rRNA construct M5 was determined | 2002 | Bioorganic & medicinal chemistry letters, Aug-19, Volume: 12, Issue:16 | Decoding region bubble size and aminoglycoside antibiotic binding. |
| AID740236 | Antibacterial activity against Escherichia coli ATCC 25922 assessed as growth inhibition after 24 hrs by MTT assay | 2013 | Bioorganic & medicinal chemistry, Apr-15, Volume: 21, Issue:8 | Novel 1,3,4-oxadiazole thioether derivatives targeting thymidylate synthase as dual anticancer/antimicrobial agents. |
| AID1079938 | Chronic liver disease either proven histopathologically, or through a chonic elevation of serum amino-transferase activity after 6 months. Value is number of references indexed. [column 'CHRON' in source] | |||
| AID278524 | Antimicrobial activity against Bifidobacterium bifidum BB12 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID565229 | Antimicrobial activity against Mycobacterium chelonae ATCC 35752 harboring pZS01 carrying mspA gene by resazurine microtiter assay | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Role of porins in the susceptibility of Mycobacterium smegmatis and Mycobacterium chelonae to aldehyde-based disinfectants and drugs. |
| AID534345 | Antimicrobial activity against Burkholderia pseudomallei Bp175 harboring mini-Tn7T-P1-bpeR+ after 24 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | The BpeAB-OprB efflux pump of Burkholderia pseudomallei 1026b does not play a role in quorum sensing, virulence factor production, or extrusion of aminoglycosides but is a broad-spectrum drug efflux system. |
| AID1562298 | Inhibition of STPK in Mycobacterium smegmatis MC2 155 expressing aminoglycoside phophotransferase-8 assessed as growth inhibition at 350 microg/disk after 18 hrs by paper disk method | 2019 | European journal of medicinal chemistry, Sep-15, Volume: 178 | Synthesis and antimycobacterial activity of imidazo[1,2-b][1,2,4,5]tetrazines. |
| AID1182137 | Antitubercular activity against Mycobacterium smegmatis assessed as reduction in MIC99 by checkerboard assay in presence of chlorpromazine sulfoxide relative to control | 2014 | Bioorganic & medicinal chemistry, Aug-15, Volume: 22, Issue:16 | Pharmacologically active metabolites, combination screening and target identification-driven drug repositioning in antituberculosis drug discovery. |
| AID400957 | Antimicrobial activity against Staphylococcus aureus ATCC 25923 by serial broth microdilution method | 2004 | Journal of natural products, Apr, Volume: 67, Issue:4 | Further labdane and kaurane diterpenoids and other constituents from Plectranthus fruticosus. |
| AID574584 | Antimycobacterial activity against extensively drug-resistant Mycobacterium tuberculosis isolate 625 obtained from sputum of patient at 4 ug/ml by Bactec MGIT960 modified proportion method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Emergence and molecular characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates from the Delhi Region in India. |
| AID584340 | Antibacterial activity against tolC deficient Escherichia coli GD100 presence of 15 mM of glutathione | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics. |
| AID1710566 | Antibacterial activity against Escherichia coli ATCC 25922 assessed as reduction in bacterial growth at 64 uM incubated for 15 to 20 hrs by broth microdilution method relative to control | 2018 | MedChemComm, Jul-01, Volume: 9, Issue:7 | Targeting miRNA by tunable small molecule binders: peptidic aminosugar mediated interference in miR-21 biogenesis reverts epithelial to mesenchymal transition. |
| AID1337846 | Antifungal activity against Aspergillus niger NCIM 1196 by standard agar method | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Quinolidene-rhodanine conjugates: Facile synthesis and biological evaluation. |
| AID1585652 | Antibacterial activity against methicillin-resistant Staphylococcus aureus after overnight incubation by micro broth dilution analysis | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Discovery of novel arylethenesulfonyl fluorides as potential candidates against methicillin-resistant of Staphylococcus aureus (MRSA) for overcoming multidrug resistance of bacterial infections. |
| AID1616907 | Antibacterial activity against Mycobacterium smegmatis ATCC 700084 incubated for 24 hrs by broth microdilution method | |||
| AID1830090 | Antibacterial activity against Staphylococcus aureus assessed as bacterial growth inhibition measured after 16 to 20 hrs by broth dilution method | |||
| AID544282 | Antimicrobial activity against Enterococcus faecalis NKH12 harboring pMG2200-like and pMG2201-like plasmids after 24 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Isolation of VanB-type Enterococcus faecalis strains from nosocomial infections: first report of the isolation and identification of the pheromone-responsive plasmids pMG2200, Encoding VanB-type vancomycin resistance and a Bac41-type bacteriocin, and pMG2 |
| AID278266 | Antimicrobial activity against Salmonella enterica serovar Typhimurium CHS18 acrAB::Kan with GyrA S38F mutation | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials. |
| AID523002 | Cytotoxicity against human 5637 cells assessed as mild induction of cell death by LDH release assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Persistence of uropathogenic Escherichia coli in the face of multiple antibiotics. |
| AID563512 | Antimicrobial activity against cetylpyridinium chloride-resistant Serratia marcescens 011 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Mutational upregulation of a resistance-nodulation-cell division-type multidrug efflux pump, SdeAB, upon exposure to a biocide, cetylpyridinium chloride, and antibiotic resistance in Serratia marcescens. |
| AID544287 | Antimicrobial activity against Enterococcus faecalis NKH17 harboring pMG2200-like plasmid after 24 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Isolation of VanB-type Enterococcus faecalis strains from nosocomial infections: first report of the isolation and identification of the pheromone-responsive plasmids pMG2200, Encoding VanB-type vancomycin resistance and a Bac41-type bacteriocin, and pMG2 |
| AID1287398 | Antimicrobial activity against Klebsiella pneumoniae after 24 hrs by serial two-fold microbroth dilution method | 2016 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 26, Issue:6 | One-pot synthesis and antimicrobial evaluation of novel 3-cyanopyridine derivatives of (-)-β-pinene. |
| AID774294 | Antimycobacterial activity against cycloserine-resistant Mycobacterium tuberculosis ATCC 35826 | 2013 | Journal of natural products, Oct-25, Volume: 76, Issue:10 | Chlorinated coumarins from the polypore mushroom Fomitopsis officinalis and their activity against Mycobacterium tuberculosis. |
| AID1182144 | Antitubercular activity against Mycobacterium smegmatis by checkerboard assay in presence of chlorpromazine sulfoxide | 2014 | Bioorganic & medicinal chemistry, Aug-15, Volume: 22, Issue:16 | Pharmacologically active metabolites, combination screening and target identification-driven drug repositioning in antituberculosis drug discovery. |
| AID1557264 | Antitubercular activity against resistant Mycobacterium tuberculosis harboring rrs A1401G mutant after 3 to 6 weeks | 2019 | MedChemComm, Aug-01, Volume: 10, Issue:8 | Drug-resistance in |
| AID404902 | Antimicrobial activity against Enterococcus faecalis ATCC 29212 by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | High-level gentamicin resistance mediated by a Tn4001-like transposon in seven nonclonal hospital isolates of Streptococcus pasteurianus. |
| AID330985 | Antimicrobial activity against Staphylococcus epidermis | 2007 | Nature, May-03, Volume: 447, Issue:7140 | PTC124 targets genetic disorders caused by nonsense mutations. |
| AID523020 | Ratio of Kcat to Km for aminoglycoside 3'-phosphotransferase 1B by PK/LDH-coupled assay in presence of ATP | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Nucleotide selectivity of antibiotic kinases. |
| AID278549 | Antimicrobial activity against 90 mins oxgall-stressed Bifidobacterium breve ATCC 15700 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID1262362 | Antibacterial activity against clinical isolates Staphylococcus aureus after 24 hrs by agar diffusion assay | 2015 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 25, Issue:24 | PPL catalyzed four-component PASE synthesis of 5-monosubstituted barbiturates: Structure and pharmacological properties. |
| AID445288 | Antibacterial activity against Mycobacterium smegmatis by broth dilution method | 2009 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 19, Issue:22 | Synthesis of new sugar derivatives and evaluation of their antibacterial activities against Mycobacterium tuberculosis. |
| AID556564 | Antimicrobial activity against sodA, sodB gene-deficient Escherichia coli K-12 3156 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Contribution of oxidative damage to antimicrobial lethality. |
| AID1263044 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 at 0.5 mM after 24 to 48 hrs by Kirby-Bauer disc diffusion susceptibility test | 2015 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 25, Issue:24 | Synthesis and biological evaluation of pyrazolopyrimidines as potential antibacterial agents. |
| AID529457 | Antimicrobial activity against Klebsiella pneumoniae containing PFGE clone B expressing beta-lactamase Oxa-48, TEM-1, CTX-M-15 and Oxa-1 by Etest | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Spread of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in Istanbul, Turkey. |
| AID368418 | Antimicrobial activity against multidrug-resistant Escherichia coli C316 pHPA containing mutated GyrA gene by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | New plasmid-mediated fluoroquinolone efflux pump, QepA, found in an Escherichia coli clinical isolate. |
| AID1478532 | Ratio of MIC for aminoglycosides-resistant Escherichia coli BL21 harboring pETSACG1 encode for APH(3')-3a resistance enzyme to MIC for Escherichia coli BL21 | 2017 | Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11 | Covalently linked kanamycin - Ciprofloxacin hybrid antibiotics as a tool to fight bacterial resistance. |
| AID556560 | Antimicrobial activity against Escherichia coli K-12 BW25113 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Contribution of oxidative damage to antimicrobial lethality. |
| AID369072 | Antimicrobial activity against Bacillus subtilis ATCC 6633 after 24 hrs by MTT assay | 2009 | Bioorganic & medicinal chemistry, Feb-01, Volume: 17, Issue:3 | Synthesis, structure and antibacterial activity of new 2-(1-(2-(substituted-phenyl)-5-methyloxazol-4-yl)-3-(2-substitued-phenyl)-4,5-dihydro-1H-pyrazol-5-yl)-7-substitued-1,2,3,4-tetrahydroisoquinoline derivatives. |
| AID1169513 | Antibacterial activity against Escherichia coli after 24 hrs by MTT method | 2014 | Bioorganic & medicinal chemistry letters, Sep-28 | Design, synthesis and biological evaluation of metronidazole-thiazole derivatives as antibacterial inhibitors. |
| AID1169513 | Antibacterial activity against Escherichia coli after 24 hrs by MTT method | 2014 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22 | Design, synthesis and biological evaluation of metronidazole-thiazole derivatives as antibacterial inhibitors. |
| AID1617683 | Antibacterial activity against Bacillus thuringiensis BT01 by CLSI based two-fold serial dilution method | |||
| AID244862 | In-vitro minimum inhibitory concentration against the growth of Escherichia coli | 2005 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 15, Issue:13 | Synthesis of (1,4)-naphthoquinono-[3,2-c]-1H-pyrazoles and their (1,4)-naphthohydroquinone derivatives as antifungal, antibacterial, and anticancer agents. |
| AID1202743 | Antimicrobial activity against Micrococcus luteus assessed as reduction in bacterial growth incubated for 48 hrs by microbroth dilution method | 2015 | Journal of natural products, Feb-27, Volume: 78, Issue:2 | Prenylated benzophenones from Triadenum japonicum. |
| AID1271377 | Antimicrobial activity against Gram-positive Bacillus cereus ATCC 17788 after 16 to 24 hrs by micro-dilution method | 2015 | ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11 | Synthesis and Biological Activity of Mono- and Di-N-acylated Aminoglycosides. |
| AID584336 | Antibacterial activity against wild type Escherichia coli BW25113 presence of 15 mM of glutathione | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics. |
| AID424337 | Antibacterial activity against fusidic acid-resistant Staphylococcus aureus AH194 harboring Pro404Leu mutation in fusA gene after 18 to 24 hrs by Etest strip assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID69666 | Minimum inhibitory concentration (MIC) was measured against Escherichia coli ATCC 25922. | 1995 | Journal of medicinal chemistry, Nov-10, Volume: 38, Issue:23 | Synthesis and antimicrobial and toxicological studies of amino acid and peptide derivatives of kanamycin A and netilmicin. |
| AID1263045 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 at 0.1 mM after 24 to 48 hrs by Kirby-Bauer disc diffusion susceptibility test | 2015 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 25, Issue:24 | Synthesis and biological evaluation of pyrazolopyrimidines as potential antibacterial agents. |
| AID278234 | Antimicrobial activity against Salmonella enterica serovar Typhimurium GyrA S21-1 acrAB::Kan with GyrA S83F mutation | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials. |
| AID1202746 | Antimicrobial activity against Candida albicans IFM62680 assessed as reduction in bacterial growth incubated for 48 hrs by microbroth dilution method | 2015 | Journal of natural products, Feb-27, Volume: 78, Issue:2 | Prenylated benzophenones from Triadenum japonicum. |
| AID1296450 | Inhibition of proteosynthesis in Mycobacterium tuberculosis H37Ra assessed as reduction of [14C]-methionine incorporation at 5 ug/ml preincubated for 1 hr followed by radiolabeling with [14C]-methionine for 24 hrs by scintillation spectrometry | 2016 | Journal of medicinal chemistry, Mar-24, Volume: 59, Issue:6 | Development of 3,5-Dinitrobenzylsulfanyl-1,3,4-oxadiazoles and Thiadiazoles as Selective Antitubercular Agents Active Against Replicating and Nonreplicating Mycobacterium tuberculosis. |
| AID283529 | Antibacterial activity against Pseudomonas aeruginosa PAO1 by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides. |
| AID445289 | Antibacterial activity against Staphylococcus aureus by broth dilution method | 2009 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 19, Issue:22 | Synthesis of new sugar derivatives and evaluation of their antibacterial activities against Mycobacterium tuberculosis. |
| AID1176776 | Antimicrobial activity against methicillin-sensitive and vancomycin-intermediate Staphylococcus aureus ATCC 25923 after 24 hrs by broth microdilution method | 2015 | Journal of natural products, Jan-23, Volume: 78, Issue:1 | Structure and antimicrobial activity of phloroglucinol derivatives from Achyrocline satureioides. |
| AID428872 | Antibacterial activity against Escherichia coli JM109 carrying pMCL-BE by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Novel plasmid-mediated 16S rRNA m1A1408 methyltransferase, NpmA, found in a clinically isolated Escherichia coli strain resistant to structurally diverse aminoglycosides. |
| AID424346 | Antibacterial activity against fusidic acid-resistant Staphylococcus aureus AH193 harboring TAA stop codon at nucleotide 299 in rplF gene after 18 to 24 hrs by Etest strip assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID434367 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 24 hrs by broth microdilution method | 2009 | European journal of medicinal chemistry, Aug, Volume: 44, Issue:8 | Design, synthesis and biological evaluation of novel nitrogen and sulfur containing hetero-1,4-naphthoquinones as potent antifungal and antibacterial agents. |
| AID540212 | Mean residence time in human after iv administration | 2008 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7 | Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. |
| AID584328 | Antibacterial activity against gshB deficient Escherichia coli JW2914-1 | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics. |
| AID1866148 | Antibacterial activity against Mycobacterium smegmatis ATCC 700084 assessed as inhibition of bacterial growth incubated for overnight by serial dilution method | |||
| AID1879067 | Antibacterial activity against pET28a-NDM-1 positive Escherichia coli BL21(DE3) isolates assessed as inhibition of bacterial growth incubated for 18 to 24 hrs by CLSI based broth microdilution method | 2022 | European journal of medicinal chemistry, Mar-05, Volume: 231 | Metallo-β-lactamases inhibitor fisetin attenuates meropenem resistance in NDM-1-producing Escherichia coli. |
| AID774292 | Selectivity index, ratio of IC50 for african green monkey Vero cells to MIC90 for Mycobacterium tuberculosis H37Rv ATCC 27294 by microplate Alamar blue assay | 2013 | Journal of natural products, Oct-25, Volume: 76, Issue:10 | Chlorinated coumarins from the polypore mushroom Fomitopsis officinalis and their activity against Mycobacterium tuberculosis. |
| AID574809 | Antimycobacterial activity against extensively drug-resistant Mycobacterium tuberculosis isolate 2474 horboring rpoB H526Y, katG D329A/R463L, gyrA D94G/S95T, rrs A1401G by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Emergence and molecular characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates from the Delhi Region in India. |
| AID278242 | Antimicrobial activity against Salmonella enterica serovar Typhimurium S21-3 acrAB::Kan with GyrA S83F, ParC S80I mutation | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials. |
| AID278801 | Antimicrobial activity against recombinant Escherichia coli DH5alpha expressing pBAD | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Aph(3')-IIc, an aminoglycoside resistance determinant from Stenotrophomonas maltophilia. |
| AID1132235 | Antibacterial activity against pigmented Serratia 155 assessed as growth inhibition by agar dilution method | 1978 | Journal of medicinal chemistry, Feb, Volume: 21, Issue:2 | Chemical modification of 1,4-diamino-1,4-dideoxy-3-O-(4-deoxy-4-propionamido-alpha-D-glucopyranosyl)-D-glucitol. |
| AID1413331 | Antifungal activity against resistant Candida albicans ATCC 64124 | 2018 | MedChemComm, Jun-01, Volume: 9, Issue:6 | Antifungal amphiphilic kanamycins: new life for an old drug. |
| AID569262 | Antimicrobial activity against Escherichia coli DH5alpha | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Synthesis and evaluation of anti-tubercular activity of new dithiocarbamate sugar derivatives. |
| AID523004 | Antibacterial activity against uropathogenic Escherichia coli UTI89 assessed as degradation of preexisting biofilm after 24 hrs by microscopy | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Persistence of uropathogenic Escherichia coli in the face of multiple antibiotics. |
| AID330987 | Antimicrobial activity against Enterococcus faecalis 29212 | 2007 | Nature, May-03, Volume: 447, Issue:7140 | PTC124 targets genetic disorders caused by nonsense mutations. |
| AID530050 | Antimicrobial activity against Staphylococcus aureus 286607-R1 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Discovery and characterization of QPT-1, the progenitor of a new class of bacterial topoisomerase inhibitors. |
| AID1426252 | Antibacterial activity against Escherichia coli ATCC 25922 | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | Synthesis and bioactivity investigation of quinone-based dimeric cationic triazolium amphiphiles selective against resistant fungal and bacterial pathogens. |
| AID1167351 | Antibacterial activity against Pseudomonas aeruginosa PAO1 mexAB/mexCD/mexXY/mexHI/opmH deletion mutant after 18 to 24 hrs by two-fold broth microdilution method | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21 | Design, synthesis, and antibacterial properties of dual-ligand inhibitors of acetyl-CoA carboxylase. |
| AID1663462 | Antibacterial activity against methicillin-resistant Staphylococcus aureus shhs-A1 incubated for 16 hrs by broth microdilution method | 2020 | Journal of natural products, 06-26, Volume: 83, Issue:6 | Antibacterial Pentacyclic Polyketides from a Soil-Derived |
| AID278240 | Antimicrobial activity against Salmonella enterica serovar Typhimurium S21-3 with GyrA S83F, ParC S80I mutation | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials. |
| AID290144 | Antibacterial activity against Bacillus subtilis after 24 hrs by MTT colorimetric method | 2007 | European journal of medicinal chemistry, Apr, Volume: 42, Issue:4 | Synthesis and antimicrobial activities of Schiff bases derived from 5-chloro-salicylaldehyde. |
| AID164255 | Antibacterial activity expressed as MIC value was determined on Pseudomonas aeruginosa A-21294 organism | 1986 | Journal of medicinal chemistry, May, Volume: 29, Issue:5 | Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin. |
| AID1337841 | Antifungal activity against Candida albicans NCIM 3471 by standard agar method | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Quinolidene-rhodanine conjugates: Facile synthesis and biological evaluation. |
| AID540929 | Antimicrobial activity against paromomycin-resistant Streptomyces coelicolor KO-347 harboring rpsl P91S mutant gene after 48 hrs | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | A novel insertion mutation in Streptomyces coelicolor ribosomal S12 protein results in paromomycin resistance and antibiotic overproduction. |
| AID520701 | Antibacterial activity against tnpR/tnpA positive tetracycline resistant Streptococcus pneumoniae clinical isolate expressing Tn3872 carrying erm(B) and tet(M) gene at 1000 ug by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | erm(B)-carrying elements in tetracycline-resistant pneumococci and correspondence between Tn1545 and Tn6003. |
| AID584329 | Antibacterial activity against gspS deficient Escherichia coli JW2956-1 | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics. |
| AID163280 | Minimum inhibitory concentration (MIC) was measured against Pseudomonas aeruginosa. | 1995 | Journal of medicinal chemistry, Nov-10, Volume: 38, Issue:23 | Synthesis and antimicrobial and toxicological studies of amino acid and peptide derivatives of kanamycin A and netilmicin. |
| AID1478536 | Inhibition of Escherichia coli DNA gyrase using relaxed pBR322 DNA as substrate by agarose gel electrophorosis method | 2017 | Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11 | Covalently linked kanamycin - Ciprofloxacin hybrid antibiotics as a tool to fight bacterial resistance. |
| AID1443980 | Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate transport preincubated for 10 mins prior to ATP addition measured after 15 mins in presence of [3H]-tauroch | 2010 | Toxicological sciences : an official journal of the Society of Toxicology, Dec, Volume: 118, Issue:2 | Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. |
| AID1326386 | Antibacterial activity against Bacillus subtilis P10B derived after 10 passage in presence of JBIR-100 after 16 to 18 hrs by microbroth dilution assay | 2016 | Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24 | Biological characterization of the hygrobafilomycin antibiotic JBIR-100 and bioinformatic insights into the hygrolide family of natural products. |
| AID1271380 | Antimicrobial activity against Gram-positive Staphylococcus aureus ATCC 29213 after 16 to 24 hrs by micro-dilution method | 2015 | ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11 | Synthesis and Biological Activity of Mono- and Di-N-acylated Aminoglycosides. |
| AID1337798 | Antibacterial activity against Escherichia coli NCIM 2688 measured after 8 hrs | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Quinolidene-rhodanine conjugates: Facile synthesis and biological evaluation. |
| AID404900 | Antibacterial activity against high-level gentamicin resistant Streptococcus pasteurianus SB40 isolate carrying transposon-borne resistance gene [aac(6')Ie-aph(2'')Ia] by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | High-level gentamicin resistance mediated by a Tn4001-like transposon in seven nonclonal hospital isolates of Streptococcus pasteurianus. |
| AID278526 | Antimicrobial activity against Bifidobacterium infantis ATCC 15697 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID342021 | Antibacterial activity against Klebsiella pneumoniae NK29 by broth microdilution test | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Sequencing and comparative genomic analysis of pK29, a 269-kilobase conjugative plasmid encoding CMY-8 and CTX-M-3 beta-lactamases in Klebsiella pneumoniae. |
| AID278562 | Antimicrobial activity against 90 mins hydrogen peroxide-stressed Bifidobacterium breve R0070 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID1167355 | Antibacterial activity against moiramide-resistant Escherichia coli D21 tolC deletion mutant after 18 to 24 hrs by two-fold broth microdilution method | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21 | Design, synthesis, and antibacterial properties of dual-ligand inhibitors of acetyl-CoA carboxylase. |
| AID207039 | Antibacterial activity expressed as MIC value was determined on Staphylococcus aureus A-21978 organism | 1986 | Journal of medicinal chemistry, May, Volume: 29, Issue:5 | Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin. |
| AID330986 | Antimicrobial activity against Enterococcus faecium 49624 | 2007 | Nature, May-03, Volume: 447, Issue:7140 | PTC124 targets genetic disorders caused by nonsense mutations. |
| AID1413332 | Antifungal activity against sensitive Candida albicans MYA-2876 | 2018 | MedChemComm, Jun-01, Volume: 9, Issue:6 | Antifungal amphiphilic kanamycins: new life for an old drug. |
| AID1413330 | Antifungal activity against Candida albicans ATCC 10231 | 2018 | MedChemComm, Jun-01, Volume: 9, Issue:6 | Antifungal amphiphilic kanamycins: new life for an old drug. |
| AID1830087 | Antibacterial activity against Bacillus subtilis E168 assessed as bacterial growth inhibition measured after 16 to 20 hrs by broth dilution method | |||
| AID278253 | Antimicrobial activity against Salmonella enterica serovar Typhimurium CS3 gyrA+ with GyrA S83F, D87N, ParC S80I mutation | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials. |
| AID460286 | Antibacterial activity against aminoglycoside-susceptible Staphylococcus aureus ATCC 25923 after 12 to 18 hrs | 2010 | Bioorganic & medicinal chemistry, Feb-15, Volume: 18, Issue:4 | Synthesis of novel aminoglycosides via allylic azide rearrangement for investigating the significance of 2'-amino group. |
| AID1326390 | Antibacterial activity against Bacillus subtilis P10C derived after 10 passage in presence of JBIR-100 after 16 to 18 hrs by microbroth dilution assay relative to Bacillus subtilis ATCC 47096 | 2016 | Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24 | Biological characterization of the hygrobafilomycin antibiotic JBIR-100 and bioinformatic insights into the hygrolide family of natural products. |
| AID69667 | Minimum inhibitory concentration (MIC) was measured against Escherichia coli ATCC 35218. | 1995 | Journal of medicinal chemistry, Nov-10, Volume: 38, Issue:23 | Synthesis and antimicrobial and toxicological studies of amino acid and peptide derivatives of kanamycin A and netilmicin. |
| AID1164944 | Antimicrobial activity against tolC-deficient Escherichia coli by microbroth dilution method | 2014 | Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20 | Synthesis, structure-activity relationship studies, and antibacterial evaluation of 4-chromanones and chalcones, as well as olympicin A and derivatives. |
| AID584823 | Inactivation of Pseudomonas putida PAW340 biofilms assessed as decrease in heat production at 3 to 30 ug/ml by Chip calorimetry | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Chip calorimetry for fast and reliable evaluation of bactericidal and bacteriostatic treatments of biofilms. |
| AID69665 | Minimum inhibitory concentration (MIC) was measured against Escherichia coli. | 1995 | Journal of medicinal chemistry, Nov-10, Volume: 38, Issue:23 | Synthesis and antimicrobial and toxicological studies of amino acid and peptide derivatives of kanamycin A and netilmicin. |
| AID601493 | Antibacterial activity against Staphylococcus aureus MTCC 2940 at 30 ug/disc after 24 hrs | 2011 | European journal of medicinal chemistry, Jun, Volume: 46, Issue:6 | Evaluation of antioxidant and antimicrobial activities of Bergenin and its derivatives obtained by chemoenzymatic synthesis. |
| AID424570 | Antibacterial activity against stationary-phase rifampin-resistant Staphylococcus aureus 8325-4 culture assessed as number of viable colonies at 16 ug/ ml after 48 hrs | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID1265791 | Antibacterial activity against Staphylococcus aureus NRS383 (USA 200) by microdilution method | 2015 | Journal of medicinal chemistry, Dec-10, Volume: 58, Issue:23 | Synthesis and Bioactivities of Kanamycin B-Derived Cationic Amphiphiles. |
| AID524390 | Antibacterial activity against Escherichia coli NKE1316 harboring deletion mutation in acrB, acrD and mdtABC protein | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Effect of NlpE overproduction on multidrug resistance in Escherichia coli. |
| AID420207 | Antimicrobial activity against Pseudomonas aeruginosa UFPEDA 39 at 30 ug/disk after 24 hrs by disk diffusion method | 2009 | European journal of medicinal chemistry, May, Volume: 44, Issue:5 | Synthesis, antimicrobial and cytotoxic activities of some 5-arylidene-4-thioxo-thiazolidine-2-ones. |
| AID1869565 | Antibacterial activity against Enterococcus faecium DSM 20477 assessed as reduction in bacterial growth measured after 3 days by broth microdilution method | 2022 | Journal of natural products, 06-24, Volume: 85, Issue:6 | Triculamin: An Unusual Lasso Peptide with Potent Antimycobacterial Activity. |
| AID1455937 | Antifungal activity against Aspergillus niger after 96 hrs by broth micro-dilution method | 2017 | Journal of natural products, 02-24, Volume: 80, Issue:2 | Nabscessins A and B, Aminocyclitol Derivatives from Nocardia abscessus IFM 10029 |
| AID283559 | Antibacterial activity against Escherichia coli AG102MB after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Substrate competition studies using whole-cell accumulation assays with the major tripartite multidrug efflux pumps of Escherichia coli. |
| AID1551812 | Antibacterial activity against Bacillus anthracis incubated for 18 hrs post 30 mins pre-diffusion by disk diffusion method | 2019 | European journal of medicinal chemistry, Jul-01, Volume: 173 | Antibacterial activity study of 1,2,4-triazole derivatives. |
| AID560600 | Antimicrobial activity against Escherichia coli JM109 transformant harboring pSTV28 plasmid expressing aac(6')-Iaf (TTG-ATG) mutant gene by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | AAC(6')-Iaf, a novel aminoglycoside 6'-N-acetyltransferase from multidrug-resistant Pseudomonas aeruginosa clinical isolates. |
| AID1491153 | Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate shhs-A1 by CLSI method | 2017 | Journal of natural products, 05-26, Volume: 80, Issue:5 | Antimicrobial Spirotetronate Metabolites from Marine-Derived Micromonospora harpali SCSIO GJ089. |
| AID278557 | Antimicrobial activity against 90 mins oxgall-stressed Bifidobacterium thermophilum ATCC 25866 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID1202744 | Antimicrobial activity against Aspergillus niger IFM62678 assessed as reduction in bacterial growth incubated for 48 hrs by microbroth dilution method | 2015 | Journal of natural products, Feb-27, Volume: 78, Issue:2 | Prenylated benzophenones from Triadenum japonicum. |
| AID1262359 | Antibacterial activity against clinical isolate Gram-positive Bacillus subtilis after 24 hrs by agar diffusion assay | 2015 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 25, Issue:24 | PPL catalyzed four-component PASE synthesis of 5-monosubstituted barbiturates: Structure and pharmacological properties. |
| AID625283 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for elevated liver function tests | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID1474166 | Liver toxicity in human assessed as induction of drug-induced liver injury by measuring severity class index | 2016 | Drug discovery today, Apr, Volume: 21, Issue:4 | DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. |
| AID163279 | Minimum inhibitory concentration (MIC) was measured against Pseudomonas aeruginosa ATCC 27853. | 1995 | Journal of medicinal chemistry, Nov-10, Volume: 38, Issue:23 | Synthesis and antimicrobial and toxicological studies of amino acid and peptide derivatives of kanamycin A and netilmicin. |
| AID1585675 | Antibiofilm activity against methicillin-resistant Staphylococcus aureus at 2 times MIC after 24 hrs by crystal violet staining-based UV-visible spectrophotometric analysis | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Discovery of novel arylethenesulfonyl fluorides as potential candidates against methicillin-resistant of Staphylococcus aureus (MRSA) for overcoming multidrug resistance of bacterial infections. |
| AID326536 | Antimicrobial activity against Mycobacterium abscessus CH10 isolate after 3 to 5 days by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | In Vitro activities of isepamicin, other aminoglycosides, and capreomycin against clinical isolates of rapidly growing mycobacteria in Taiwan. |
| AID283560 | Antibacterial activity against Escherichia coli HNCE4 after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Substrate competition studies using whole-cell accumulation assays with the major tripartite multidrug efflux pumps of Escherichia coli. |
| AID1467594 | Antibacterial activity against Klebsiella pneumoniae NBRC 14940 after 12 hrs by MTT assay | 2017 | Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14 | New merosesquiterpenes from a Vietnamese marine sponge of Spongia sp. and their biological activities. |
| AID532989 | Antibacterial activity against Klebsiella aerogenes NCIM 2281 in presence of 10 mM N-Acetylcysteine | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | N-acetylcysteine-mediated modulation of bacterial antibiotic susceptibility. |
| AID1653391 | Anti-leprotic activity against Mycobacterium leprae infected in BALB/c weanling mouse assessed as bacteria killing at 100 mg/kg, ip administrated for 60 days and measured after 1 year by most probable number technique analysis relative to control | 2019 | Bioorganic & medicinal chemistry, 07-01, Volume: 27, Issue:13 | Insights of synthetic analogues of anti-leprosy agents. |
| AID278547 | Antimicrobial activity against 90 mins oxgall-stressed Bifidobacterium bifidum ATCC 15696 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID1565712 | Antifungal activity against Candida tropicalis 95-41 incubated for 24 to 36 hrs by two fold dilution method | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Scalable and cost-effective tosylation-mediated synthesis of antifungal and fungal diagnostic 6″-Modified amphiphilic kanamycins. |
| AID1868104 | Antibacterial activity against methicillin-resistant Staphylococcus aureus clinical isolate 3B assessed as inhibition of visible bacterial growth incubated for 18 hrs by CLSI protocol based assay | 2022 | Journal of natural products, 05-27, Volume: 85, Issue:5 | Enceleamycins A-C, Furo-Naphthoquinones from |
| AID563504 | Antimicrobial activity against Serratia marcescens ATCC 13880 harboring plasmid STV29 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Mutational upregulation of a resistance-nodulation-cell division-type multidrug efflux pump, SdeAB, upon exposure to a biocide, cetylpyridinium chloride, and antibiotic resistance in Serratia marcescens. |
| AID574170 | Antibacterial activity against Escherichia coli MG1655 grown as biofilms harboring plasmid pBR322 carrying blaTEM-1 and tetA(C) genes after 24 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Induction of multidrug resistance mechanism in Escherichia coli biofilms by interplay between tetracycline and ampicillin resistance genes. |
| AID1868099 | Antibacterial activity against Bacillus cereus ATCC 11778 assessed as inhibition of visible bacterial growth incubated for 18 hrs by CLSI protocol based assay | 2022 | Journal of natural products, 05-27, Volume: 85, Issue:5 | Enceleamycins A-C, Furo-Naphthoquinones from |
| AID1869567 | Antibacterial activity against Staphylococcus aureus DSM 20231 assessed as reduction in bacterial growth measured after 3 days by broth microdilution method | 2022 | Journal of natural products, 06-24, Volume: 85, Issue:6 | Triculamin: An Unusual Lasso Peptide with Potent Antimycobacterial Activity. |
| AID1334269 | Antibacterial activity against Bacillus subtilis | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2 | New bithiazolyl hydrazones: Novel synthesis, characterization and antitubercular evaluation. |
| AID164251 | Antibacterial activity expressed as MIC value was determined on Pseudomonas aeruginosa A-20653 organism | 1986 | Journal of medicinal chemistry, May, Volume: 29, Issue:5 | Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin. |
| AID1866813 | Antifungal activity against Escherichia coli assessed as reduction in microbial growth after 24 hrs by two-fold dilution method | 2022 | Journal of natural products, 04-22, Volume: 85, Issue:4 | Secondary Metabolites from |
| AID1869570 | Bactericidal activity against Klebsiella oxytoca DSM 5175 assessed as reduction in colony count and measured after 3 days by agar diffusion assay | 2022 | Journal of natural products, 06-24, Volume: 85, Issue:6 | Triculamin: An Unusual Lasso Peptide with Potent Antimycobacterial Activity. |
| AID428870 | Antibacterial activity against Escherichia coli CSH-2 carrying Escherichia coli ARS3 pARS3 by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Novel plasmid-mediated 16S rRNA m1A1408 methyltransferase, NpmA, found in a clinically isolated Escherichia coli strain resistant to structurally diverse aminoglycosides. |
| AID1730998 | Antibacterial activity against Staphylococcus aureus Newman assessed as inhibition of bacterial growth measured after 18 hrs by two fold serial dilution method | 2021 | European journal of medicinal chemistry, Mar-05, Volume: 213 | Design and synthesis of mycobacterial pks13 inhibitors: Conformationally rigid tetracyclic molecules. |
| AID532987 | Antibacterial activity against Pseudomonas aeruginosa NCIM 5029 in presence of 10 mM N-Acetylcysteine | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | N-acetylcysteine-mediated modulation of bacterial antibiotic susceptibility. |
| AID540930 | Antimicrobial activity against paromomycin-resistant Streptomyces coelicolor 92G harboring rpsL gene with inserted glycine at position 92 after 48 hrs | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | A novel insertion mutation in Streptomyces coelicolor ribosomal S12 protein results in paromomycin resistance and antibiotic overproduction. |
| AID278270 | Antimicrobial activity against Salmonella enterica serovar Typhimurium CHS38 acrAB::Kan with GyrA D87G mutation | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials. |
| AID1326369 | Antibacterial activity against Bacillus subtilis ATCC 47096 after 16 to 18 hrs by microbroth dilution assay | 2016 | Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24 | Biological characterization of the hygrobafilomycin antibiotic JBIR-100 and bioinformatic insights into the hygrolide family of natural products. |
| AID1228000 | Antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as inhibition of visible bacterial growth incubated for 24 hrs at 37 degC by broth microdilution method | 2015 | Journal of natural products, Apr-24, Volume: 78, Issue:4 | Antibacterial Polyketide Heterodimers from Pyrenacantha kaurabassana Tubers. |
| AID424825 | Antibacterial activity against kanamycin-resistant and fusidic acid-susceptible Staphylococcus aureus AH292 harboring Gly664Val mutation in fusA gene after 18 to 24 hrs by Etest strip assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID625288 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for jaundice | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID1629123 | Antimicrobial activity against Pseudomonas aeruginosa ATCC 27853 measured after 24 hrs by double-dilution method | 2016 | Journal of medicinal chemistry, 09-08, Volume: 59, Issue:17 | Effects of 5-O-Ribosylation of Aminoglycosides on Antimicrobial Activity and Selective Perturbation of Bacterial Translation. |
| AID1287416 | Antimycobacterial activity against Mycobacterium bovis BCG overexpressing InhA after 2 weeks | 2016 | European journal of medicinal chemistry, Apr-13, Volume: 112 | New direct inhibitors of InhA with antimycobacterial activity based on a tetrahydropyran scaffold. |
| AID1557266 | Antitubercular activity against resistant Mycobacterium tuberculosis harboring rrs G1484T/C-12T mutant after 3 to 6 weeks | 2019 | MedChemComm, Aug-01, Volume: 10, Issue:8 | Drug-resistance in |
| AID1077166 | Antibacterial activity against Bacillus subtilis after 12 hrs by MTT assay | 2014 | European journal of medicinal chemistry, Apr-09, Volume: 76 | Design and synthesis of 2-styryl of 5-Nitroimidazole derivatives and antimicrobial activities as FabH inhibitors. |
| AID1230066 | Antibacterial activity against methicillin-resistant Staphylococcus aureus GRE2691 assessed as inhibition of bacterial growth | 2015 | Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13 | Synthesis and antimicrobial activity of chloramphenicol-polyamine conjugates. |
| AID532031 | Antimicrobial activity against Escherichia coli TOP10F' by disk diffusion method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Novel chromosome-encoded CTX-M-78 beta-lactamase from a Kluyvera georgiana clinical isolate as a putative origin of CTX-M-25 subgroup. |
| AID283648 | Susceptibility of Escherichia coli K12 MG1655 in presence of 10 mM glutathione by agar dilution method relative to control | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Effects of glutathione and ascorbic acid on streptomycin sensitivity of Escherichia coli. |
| AID718274 | Antimicrobial activity against Staphylococcus aureus ATCC 29213 | 2012 | Journal of natural products, Dec-28, Volume: 75, Issue:12 | Marthiapeptide A, an anti-infective and cytotoxic polythiazole cyclopeptide from a 60 L scale fermentation of the deep sea-derived Marinactinospora thermotolerans SCSIO 00652. |
| AID551748 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 33591 after 12 to 18 hrs by twofold dilution method | 2011 | Bioorganic & medicinal chemistry, Jan-01, Volume: 19, Issue:1 | Synthesis and antibacterial activity study of a novel class of cationic anthraquinone analogs. |
| AID771494 | Antibacterial activity against Escherichia coli by dilution technique | 2013 | European journal of medicinal chemistry, Oct, Volume: 68 | Synthesis and biological evaluation of novel ocotillol-type triterpenoid derivatives as antibacterial agents. |
| AID1402054 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 after 18 to 20 hrs by spectrophotometry based microdilution method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Synthesis and antimicrobial activity of amino acid and peptide derivatives of mycophenolic acid. |
| AID1629125 | Antimicrobial activity against Haemophilus influenzae ATCC 10211 measured after 24 hrs by double-dilution method | 2016 | Journal of medicinal chemistry, 09-08, Volume: 59, Issue:17 | Effects of 5-O-Ribosylation of Aminoglycosides on Antimicrobial Activity and Selective Perturbation of Bacterial Translation. |
| AID1079935 | Cytolytic liver toxicity, either proven histopathologically or where the ratio of maximal ALT or AST activity above normal to that of Alkaline Phosphatase is > 5 (see ACUTE). Value is number of references indexed. [column 'CYTOL' in source] | |||
| AID1594069 | Antibacterial activity against Staphylococcus aureus assessed as reduction in bacterial cell viability incubated for 20 to 24 hrs by REMA method | 2019 | Bioorganic & medicinal chemistry, 06-15, Volume: 27, Issue:12 | Design, synthesis, in-silico studies and biological screening of quinazolinone analogues as potential antibacterial agents against MRSA. |
| AID501181 | Antimicrobial activity against vancomycin-resistant Enterococcus faecium 379 at 30 ug after 18 hrs by agar diffusion method | 2009 | Journal of natural products, Oct, Volume: 72, Issue:10 | Norselic acids A-E, highly oxidized anti-infective steroids that deter mesograzer predation, from the Antarctic sponge Crella sp. |
| AID1347681 | Toxicity against Yersinia pseudotuberculosis harboring pYV deletion mutant at 50 ug/ml measured after 8 hrs by MTT assay | 2017 | Journal of natural products, 12-22, Volume: 80, Issue:12 | Investigation of the Physical and Bioactive Properties of Bromo- and Iodo-Containing Sponge-Derived Compounds Possessing an Oxyphenylethanamine Core. |
| AID1132223 | Antibacterial activity against drug-sensitive Staphylococcus aureus 2985 assessed as growth inhibition by agar dilution method | 1978 | Journal of medicinal chemistry, Feb, Volume: 21, Issue:2 | Chemical modification of 1,4-diamino-1,4-dideoxy-3-O-(4-deoxy-4-propionamido-alpha-D-glucopyranosyl)-D-glucitol. |
| AID434366 | Antibacterial activity against Escherichia coli after 24 hrs by broth microdilution method | 2009 | European journal of medicinal chemistry, Aug, Volume: 44, Issue:8 | Design, synthesis and biological evaluation of novel nitrogen and sulfur containing hetero-1,4-naphthoquinones as potent antifungal and antibacterial agents. |
| AID1585459 | Antibacterial activity against Staphylococcus aureus Newman measured after 16 hrs | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Design, synthesis and evaluation of hybrid of tetrahydrocarbazole with 2,4-diaminopyrimidine scaffold as antibacterial agents. |
| AID278554 | Antimicrobial activity against 90 mins oxgall-stressed Bifidobacterium longum R0175 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID647788 | Antibacterial activity Staphylococcus aureus at 40 ug/disc after 24 hrs by agar disc diffusion method | 2012 | European journal of medicinal chemistry, Apr, Volume: 50 | Synthesis of new α aminophosphonate system bearing Indazole moiety and their biological activity. |
| AID424599 | Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH357 (SCV-29) harboring TAA stop codon at nucleotide 301 in rplF gene after 18 to 24 hrs by Etest strip assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID1730991 | Antitubercular activity against drug susceptible Mycobacterium tuberculosis V4207 by MABA assay | 2021 | European journal of medicinal chemistry, Mar-05, Volume: 213 | Design and synthesis of mycobacterial pks13 inhibitors: Conformationally rigid tetracyclic molecules. |
| AID326544 | Antimicrobial activity against Mycobacterium abscessus R50 isolate after 3 to 5 days by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | In Vitro activities of isepamicin, other aminoglycosides, and capreomycin against clinical isolates of rapidly growing mycobacteria in Taiwan. |
| AID518754 | Microbicidal activity against Nonomuraea sp. ATCC 39727 at 5000 ug/ml after 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Novel mechanism of glycopeptide resistance in the A40926 producer Nonomuraea sp. ATCC 39727. |
| AID283532 | Antibacterial activity against Pseudomonas aeruginosa FE53 with inactivated mexZ gene by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides. |
| AID163075 | Antibacterial activity expressed as MIC value was determined on Proteus stuartii A-20894 organism | 1986 | Journal of medicinal chemistry, May, Volume: 29, Issue:5 | Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin. |
| AID569256 | Antimycobacterial activity against Mycobacterium bovis BCG str. Tokyo 172 | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Synthesis and evaluation of anti-tubercular activity of new dithiocarbamate sugar derivatives. |
| AID1347679 | Toxicity against wild-type Yersinia pseudotuberculosis at 50 ug/ml measured after 15 hrs by MTT assay | 2017 | Journal of natural products, 12-22, Volume: 80, Issue:12 | Investigation of the Physical and Bioactive Properties of Bromo- and Iodo-Containing Sponge-Derived Compounds Possessing an Oxyphenylethanamine Core. |
| AID750184 | Antibacterial activity against Pseudomonas fluorescens ATCC 13525 assessed as growth inhibition after 24 hrs by two-fold serial dilution method | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Synthesis and antimicrobical evaluation of a novel class of 1,3,4-thiadiazole: derivatives bearing 1,2,4-triazolo[1,5-a]pyrimidine moiety. |
| AID420208 | Antimicrobial activity against Escherichia coli UFPEDA 224 at 30 ug/disk after 24 hrs by disk diffusion method | 2009 | European journal of medicinal chemistry, May, Volume: 44, Issue:5 | Synthesis, antimicrobial and cytotoxic activities of some 5-arylidene-4-thioxo-thiazolidine-2-ones. |
| AID425074 | Antimicrobial activity against Escherichia coli DH10B in presence of IPTG | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Complex class 1 integrons with diverse variable regions, including aac(6')-Ib-cr, and a novel allele, qnrB10, associated with ISCR1 in clinical enterobacterial isolates from Argentina. |
| AID71052 | Compound was tested for photoinhibition of Escherichia coli (CIP 548T); No data | 1998 | Bioorganic & medicinal chemistry letters, Nov-03, Volume: 8, Issue:21 | Nitroglycosylated meso-arylporphyrins as photoinhibitors of gram positive bacteria. |
| AID509449 | Antibacterial activity against Pseudomonas fluorescens after 24 hrs by MTT assay | 2010 | European journal of medicinal chemistry, Sep, Volume: 45, Issue:9 | Design and synthesis of potent inhibitors of beta-ketoacyl-acyl carrier protein synthase III (FabH) as potential antibacterial agents. |
| AID126449 | Dissociation constant for binding to mitochondrial 12S rRNA construct M2 was determined | 2002 | Bioorganic & medicinal chemistry letters, Aug-19, Volume: 12, Issue:16 | Decoding region bubble size and aminoglycoside antibiotic binding. |
| AID424827 | Antibacterial activity against kanamycin-resistant and fusidic acid-susceptible Staphylococcus aureus AH422 harboring +2 frameshift mutation at nucleotide 222 in rplF gene after 18 to 24 hrs by Etest strip assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID523022 | Ratio of Kcat to Km for aminoglycoside 3'-phosphotransferase 1B by PK/LDH-coupled assay in presence of GTP | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Nucleotide selectivity of antibiotic kinases. |
| AID1348090 | Antimicrobial activity against Escherichia coli ATCC 25922 assessed as zone of inhibition at 50 ug per disc after 24 hrs by disc diffusion assay | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Synthesis of new 1-benzyl tetrahydropyridinylidene ammonium salts and their antimicrobial and anticellular activities. |
| AID1869563 | Antibacterial activity against Bacillus cereus DSM 31 assessed as reduction in bacterial growth measured after 3 days by broth microdilution method | 2022 | Journal of natural products, 06-24, Volume: 85, Issue:6 | Triculamin: An Unusual Lasso Peptide with Potent Antimycobacterial Activity. |
| AID647792 | Antibacterial activity Pseudomonas aeruginosa at 40 ug/disc after 24 hrs by agar disc diffusion method | 2012 | European journal of medicinal chemistry, Apr, Volume: 50 | Synthesis of new α aminophosphonate system bearing Indazole moiety and their biological activity. |
| AID563510 | Antimicrobial activity against cetylpyridinium chloride-resistant Serratia marcescens HMS011 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Mutational upregulation of a resistance-nodulation-cell division-type multidrug efflux pump, SdeAB, upon exposure to a biocide, cetylpyridinium chloride, and antibiotic resistance in Serratia marcescens. |
| AID1132240 | Antibacterial activity against drug-sensitive Brucella 965 assessed as growth inhibition by agar dilution method | 1978 | Journal of medicinal chemistry, Feb, Volume: 21, Issue:2 | Chemical modification of 1,4-diamino-1,4-dideoxy-3-O-(4-deoxy-4-propionamido-alpha-D-glucopyranosyl)-D-glucitol. |
| AID278531 | Antimicrobial activity against Bifidobacterium pseudolongum ATCC 25562 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID1565713 | Antifungal activity against Cryptococcus neoformans H99 incubated for 24 to 36 hrs by two fold dilution method | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Scalable and cost-effective tosylation-mediated synthesis of antifungal and fungal diagnostic 6″-Modified amphiphilic kanamycins. |
| AID1657553 | Antimicrobial activity against Staphylococcus aureus incubated for 7 hrs by alamar Blue assay | |||
| AID537735 | Binding affinity to Candida albicans CaMdr1p expressed in yeast AD1-8u | 2010 | European journal of medicinal chemistry, Nov, Volume: 45, Issue:11 | Analysis of physico-chemical properties of substrates of ABC and MFS multidrug transporters of pathogenic Candida albicans. |
| AID405822 | Antimicrobial activity against Escherichia coli DH5alpha | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Characterization of an integron carrying blaIMP-1 and a new aminoglycoside resistance gene, aac(6')-31, and its dissemination among genetically unrelated clinical isolates in a Brazilian hospital. |
| AID1585460 | Antibacterial activity against aminoglycosides/tetracycline-resistant Staphylococcus aureus NRS-1 measured after 16 hrs | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Design, synthesis and evaluation of hybrid of tetrahydrocarbazole with 2,4-diaminopyrimidine scaffold as antibacterial agents. |
| AID476721 | Antibacterial activity against Pseudomonas aeruginosa ATCC 13525 after 24 hrs by colorimetric method using dye MTT | 2010 | Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7 | Synthesis, molecular modeling and biological evaluation of PSB as targeted antibiotics. |
| AID718271 | Antimicrobial activity against Aeromonas hydrophila subsp. hydrophila ATCC 7966 | 2012 | Journal of natural products, Dec-28, Volume: 75, Issue:12 | Marthiapeptide A, an anti-infective and cytotoxic polythiazole cyclopeptide from a 60 L scale fermentation of the deep sea-derived Marinactinospora thermotolerans SCSIO 00652. |
| AID1271384 | Antimicrobial activity against Gram-negative Pseudomonas aeruginosa PAO1 after 16 to 24 hrs by micro-dilution method | 2015 | ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11 | Synthesis and Biological Activity of Mono- and Di-N-acylated Aminoglycosides. |
| AID544275 | Antimicrobial activity against Enterococcus faecalis NKH5 harboring pMG2200-like plasmid after 24 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Isolation of VanB-type Enterococcus faecalis strains from nosocomial infections: first report of the isolation and identification of the pheromone-responsive plasmids pMG2200, Encoding VanB-type vancomycin resistance and a Bac41-type bacteriocin, and pMG2 |
| AID1228002 | Antibacterial activity against Staphylococcus aureus isolated from tibial leg ulcer patient assessed as inhibition of visible bacterial growth incubated for 24 hrs at 37 degC by broth microdilution method | 2015 | Journal of natural products, Apr-24, Volume: 78, Issue:4 | Antibacterial Polyketide Heterodimers from Pyrenacantha kaurabassana Tubers. |
| AID1890847 | Selectivity index, ratio of MIC50 for antimycobacterial activity against Mycobacterium smegmatis mc2 155 harbouring pMyC::PDFMtb overexpression mutant to MIC50 for antimycobacterial activity against wild type Mycobacterium smegmatis mc2 155 | 2022 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 64 | Design, synthesis and antibacterial activity against pathogenic mycobacteria of conjugated hydroxamic acids, hydrazides and O-alkyl/O-acyl protected hydroxamic derivatives. |
| AID164254 | Antibacterial activity expressed as MIC value was determined on Pseudomonas aeruginosa A-20897 organism | 1986 | Journal of medicinal chemistry, May, Volume: 29, Issue:5 | Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin. |
| AID670724 | Antibacterial activity against Bacillus subtilis ATCC 530 after 24 hrs by MTT assay | 2012 | Bioorganic & medicinal chemistry, Jul-15, Volume: 20, Issue:14 | Design, synthesis and antimicrobial activities of nitroimidazole derivatives containing 1,3,4-oxadiazole scaffold as FabH inhibitors. |
| AID1413340 | Antifungal activity against Aspergillus niger | 2018 | MedChemComm, Jun-01, Volume: 9, Issue:6 | Antifungal amphiphilic kanamycins: new life for an old drug. |
| AID1182152 | Ratio of MIC99 for Mycobacterium smegmatis to ratio of MIC99 for Mycobacterium smegmatis in presence of chlorpromazine-N-oxide | 2014 | Bioorganic & medicinal chemistry, Aug-15, Volume: 22, Issue:16 | Pharmacologically active metabolites, combination screening and target identification-driven drug repositioning in antituberculosis drug discovery. |
| AID1830088 | Antibacterial activity against TolC deficient Escherichia coli assessed as bacterial growth inhibition measured after 16 to 20 hrs by broth dilution method | |||
| AID563509 | Antimicrobial activity against cetylpyridinium chloride-sensitive Serratia marcescens 79 harboring plasmid STV29 expressing hasF gene by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Mutational upregulation of a resistance-nodulation-cell division-type multidrug efflux pump, SdeAB, upon exposure to a biocide, cetylpyridinium chloride, and antibiotic resistance in Serratia marcescens. |
| AID1079939 | Cirrhosis, proven histopathologically. Value is number of references indexed. [column 'CIRRH' in source] | |||
| AID1303894 | Antibacterial activity against multidrug resistant Acinetobacter baumannii 2208 (ATCC 19606) assessed as reduction in bacterial growth incubated for 6 to 8 hrs | 2016 | Bioorganic & medicinal chemistry letters, 07-01, Volume: 26, Issue:13 | GroEL/ES inhibitors as potential antibiotics. |
| AID1207009 | Antibacterial activity against Enterococcus faecalis assessed as growth inhibition at 50 ug/disc after 24 hrs by disc diffusion method | 2015 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 25, Issue:12 | An antibacterial ortho-quinone diterpenoid and its derivatives from Caryopteris mongolica. |
| AID368424 | Ratio of MIC for Escherichia coli KAM32 pSTVqepA mutant to MIC for Escherichia coli KAM32 pSTV28 mutant | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | New plasmid-mediated fluoroquinolone efflux pump, QepA, found in an Escherichia coli clinical isolate. |
| AID1906418 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27883 assessed as reduction in microbial growth incubated for 24 hrs by microbroth dilution method | 2022 | European journal of medicinal chemistry, May-05, Volume: 235 | Amphiphilic cyclic peptide [W |
| AID278548 | Antimicrobial activity against 90 mins oxgall-stressed Bifidobacterium bifidum BB12 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID1593373 | Inhibition of Pks13 D1644G/N1640K double mutant thioesterase domain in drug-susceptible Mycobacterium tuberculosis V4207 assessed as reduction in bacterial growth by microplate alamar blue assay | 2019 | Journal of medicinal chemistry, 04-11, Volume: 62, Issue:7 | Identification of Novel Coumestan Derivatives as Polyketide Synthase 13 Inhibitors against Mycobacterium tuberculosis. Part II. |
| AID1562307 | Antimycobacterial activity against Mycobacterium smegmatis atR1 assessed as decrease in drug resistance development at 5 ug/disc after 2 to 3 days by paper disc method | 2019 | European journal of medicinal chemistry, Sep-15, Volume: 178 | Synthesis and antimycobacterial activity of imidazo[1,2-b][1,2,4,5]tetrazines. |
| AID424336 | Antibacterial activity against fusidic acid-resistant Staphylococcus aureus AH207 harboring Thr385Asn mutation in fusA gene after 18 to 24 hrs by Etest strip assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID1629124 | Antimicrobial activity against Haemophilus influenzae ATCC 49247 measured after 24 hrs by double-dilution method | 2016 | Journal of medicinal chemistry, 09-08, Volume: 59, Issue:17 | Effects of 5-O-Ribosylation of Aminoglycosides on Antimicrobial Activity and Selective Perturbation of Bacterial Translation. |
| AID381844 | Antibacterial activity against Staphylococcus aureus ATCC 6538 | 2008 | Bioorganic & medicinal chemistry, Apr-01, Volume: 16, Issue:7 | Synthesis, structure and antibacterial activity of novel 1-(5-substituted-3-substituted-4,5-dihydropyrazol-1-yl)ethanone oxime ester derivatives. |
| AID278231 | Antimicrobial activity against Salmonella enterica serovar Typhimurium S21 tolC::Kan | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials. |
| AID524393 | Antibacterial activity against Escherichia coli NKE1359 harboring deletion mutation in acrB protein and plasmid expressing BADnlpE gene in presence of increasing concentration of arabinose | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Effect of NlpE overproduction on multidrug resistance in Escherichia coli. |
| AID521599 | Antibacterial activity against Salmonella enterica serovars virchow isolate 101591 assessed as log reduction in viable counts at 150 ug/ml after 1hr | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Aminoglycosides affect intracellular Salmonella enterica serovars typhimurium and virchow. |
| AID1593374 | Inhibition of Pks13 D1644G/N1640K double mutant thioesterase domain in multidrug-resistant Mycobacterium tuberculosis V2475 assessed as reduction in bacterial growth by microplate alamar blue assay | 2019 | Journal of medicinal chemistry, 04-11, Volume: 62, Issue:7 | Identification of Novel Coumestan Derivatives as Polyketide Synthase 13 Inhibitors against Mycobacterium tuberculosis. Part II. |
| AID325449 | Antibacterial activity against Staphylococcus aureus ATCC 3556 after 14 to 16 hrs by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Polyamine effects on antibiotic susceptibility in bacteria. |
| AID584335 | Antibacterial activity against wild type Escherichia coli BW25113 presence of 10 mM of glutathione | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics. |
| AID1765579 | Antibacterial activity against Klebsiella pneumoniae ATCC 700603 incubated for 18 hrs by CLSI based broth dilution method | 2021 | Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15 | Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice. |
| AID424344 | Antibacterial activity against fusidic acid-resistant Staphylococcus aureus AH190 harboring Arg464His mutation in fusA gene after 18 to 24 hrs by Etest strip assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID1426250 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 33591 | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | Synthesis and bioactivity investigation of quinone-based dimeric cationic triazolium amphiphiles selective against resistant fungal and bacterial pathogens. |
| AID1271382 | Antimicrobial activity against Gram-positive methicillin-resistant Staphylococcus aureus 2 after 16 to 24 hrs by micro-dilution method | 2015 | ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11 | Synthesis and Biological Activity of Mono- and Di-N-acylated Aminoglycosides. |
| AID725079 | Antimicrobial activity against Bacillus subtilis after 12 to 18 hrs by micro-well dilution method | 2013 | European journal of medicinal chemistry, Jan, Volume: 59 | Synthesis and antibacterial and antifungal evaluation of some chalcone based sulfones and bisulfones. |
| AID510559 | Antibacterial activity against Escherichia coli AG102MB | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Single nucleotide polymorphism analysis of the major tripartite multidrug efflux pump of Escherichia coli: functional conservation in disparate animal reservoirs despite exposure to antimicrobial chemotherapy. |
| AID530288 | Antimicrobial activity against PR-39-resistant Salmonella enterica serovar Typhimurium LT2 DA6192 by Etest | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Mechanism and fitness costs of PR-39 resistance in Salmonella enterica serovar Typhimurium LT2. |
| AID1132228 | Antibacterial activity against drug-sensitive Escherichia coli 2482 assessed as growth inhibition by agar dilution method | 1978 | Journal of medicinal chemistry, Feb, Volume: 21, Issue:2 | Chemical modification of 1,4-diamino-1,4-dideoxy-3-O-(4-deoxy-4-propionamido-alpha-D-glucopyranosyl)-D-glucitol. |
| AID1815140 | Antibacterial activity against Escherichia coli ATCC25922 assessed as reduction in bacterial growth | 2021 | European journal of medicinal chemistry, Dec-15, Volume: 226 | Synthesis and biological evaluation of indole-based peptidomimetics as antibacterial agents against Gram-positive bacteria. |
| AID424605 | Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH362 (SCV-34) harboring TAA stop codon at nucleotide 282 in rplF gene after 18 to 24 hrs by Etest strip assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID1265785 | Antibacterial activity against Bacillus subtilis 168 by microdilution method | 2015 | Journal of medicinal chemistry, Dec-10, Volume: 58, Issue:23 | Synthesis and Bioactivities of Kanamycin B-Derived Cationic Amphiphiles. |
| AID449435 | Antimycobacterial activity against Mycobacterium tuberculosis XDR infected in MDBK by BACTEC analysis | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11 | Pentacyclo-undecane derived cyclic tetra-amines: synthesis and evaluation as potent anti-tuberculosis agents. |
| AID1887298 | Antibacterial activity against Staphylococcus epidermidis ATCC 51625 assessed as inhibition of bacterial growth incubated for 24 hrs by optical density based analysis | 2022 | Journal of natural products, 09-23, Volume: 85, Issue:9 | Total Syntheses and Antibacterial Evaluations of Neocyclomorusin and Related Flavones. |
| AID278539 | Antimicrobial activity against 60 min 1 M HCl-stressed Bifidobacterium infantis ATCC 15697 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID1565708 | Antifungal activity against azole-susceptible Candida albicans MYA2876 incubated for 24 to 36 hrs by two fold dilution method | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Scalable and cost-effective tosylation-mediated synthesis of antifungal and fungal diagnostic 6″-Modified amphiphilic kanamycins. |
| AID278803 | Antimicrobial activity against recombinant Escherichia coli DHalpha expressing pBAD [aph(3')-2] | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Aph(3')-IIc, an aminoglycoside resistance determinant from Stenotrophomonas maltophilia. |
| AID569261 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 873 | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Synthesis and evaluation of anti-tubercular activity of new dithiocarbamate sugar derivatives. |
| AID587758 | Antimicrobial activity against wild type Mycobacterium ulcerans ATCC 19423 infected BALB/c mouse assessed as reduction in foodpad CFU count after 4 weeks | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Using bioluminescence to monitor treatment response in real time in mice with Mycobacterium ulcerans infection. |
| AID424596 | Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH358 (SCV-30) harboring -1 frameshift mutation at nucleotide 423 in rplF gene after 18 to 24 hrs by Etest strip assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID1299580 | Antibacterial activity against Pseudomonas aeruginosa PAO1 ATCC 47085 incubated overnight by microbroth dilution method | 2016 | Journal of medicinal chemistry, Apr-14, Volume: 59, Issue:7 | Antibacterial Diamines Targeting Bacterial Membranes. |
| AID278540 | Antimicrobial activity against 60 min 1 M HCl-stressed Bifidobacterium longum ATCC 15707 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID1617940 | Antibacterial activity against Staphylococcus aureus ATCC 6538 after 16 to 48 hrs | 2019 | Journal of natural products, 12-27, Volume: 82, Issue:12 | Structure Determination, Functional Characterization, and Biosynthetic Implications of Nybomycin Metabolites from a Mining Reclamation Site-Associated |
| AID1303883 | Antibacterial activity against methicillin resistant Staphylococcus aureus subsp. aureus HPV107 (ATCC BAA-44) assessed as reduction in bacterial growth incubated for 6 to 8 hrs | 2016 | Bioorganic & medicinal chemistry letters, 07-01, Volume: 26, Issue:13 | GroEL/ES inhibitors as potential antibiotics. |
| AID278804 | Antimicrobial activity against recombinant Escherichia coli DH5-alpha expressing pBAD [aph(3')-2] in the presence of arabinose | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Aph(3')-IIc, an aminoglycoside resistance determinant from Stenotrophomonas maltophilia. |
| AID283543 | Antibacterial activity against Pseudomonas aeruginosa FE57UZ with inactivated rplY, galU and mexZ genes by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides. |
| AID326553 | Antimicrobial activity against Mycobacterium fortuitum V146 isolate after 3 to 5 days by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | In Vitro activities of isepamicin, other aminoglycosides, and capreomycin against clinical isolates of rapidly growing mycobacteria in Taiwan. |
| AID1869560 | Bactericidal activity against Mycobacterium phlei DSM 43239 assessed as reduction in colony count and measured after 3 days by agar diffusion assay | 2022 | Journal of natural products, 06-24, Volume: 85, Issue:6 | Triculamin: An Unusual Lasso Peptide with Potent Antimycobacterial Activity. |
| AID278256 | Antimicrobial activity against Salmonella enterica serovar Typhimurium CS9 with GyrA S83F, D87N, ParC S80I mutation | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials. |
| AID625289 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver disease | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID521591 | Antibacterial activity against Salmonella enterica serovars Typhimurium ATCC 14028 at pH 5.7 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Aminoglycosides affect intracellular Salmonella enterica serovars typhimurium and virchow. |
| AID1868098 | Antibacterial activity against Staphylococcus epidermidis ATCC 12228 assessed as inhibition of visible bacterial growth incubated for 18 hrs by CLSI protocol based assay | 2022 | Journal of natural products, 05-27, Volume: 85, Issue:5 | Enceleamycins A-C, Furo-Naphthoquinones from |
| AID1105398 | Antibacterial activity against Pseudomonas aeruginosa MTCC 2581 assessed as growth inhibition at 25 ug/disk after 24 hr by disk diffusion method | 2013 | European journal of medicinal chemistry, Jan, Volume: 59 | Microwave synthesis, characterization and bio-efficacy evaluation of novel chalcone based 6-carbethoxy-2-cyclohexen-1-one and 2H-indazol-3-ol derivatives. |
| AID30415 | Minimum inhibitory concentration (MIC) was measured against Acinetobacter lwoffi ATCC 17986. | 1995 | Journal of medicinal chemistry, Nov-10, Volume: 38, Issue:23 | Synthesis and antimicrobial and toxicological studies of amino acid and peptide derivatives of kanamycin A and netilmicin. |
| AID760037 | Antibacterial activity against Burkholderia thailandensis E264 assessed as bacterial growth inhibition at 0.5 mM after 24 hrs by two-fold dilution method relative to control | 2013 | ACS medicinal chemistry letters, Jul-01, Volume: 4, Issue:8 | Discovery of Inhibitors of |
| AID1176778 | Antimicrobial activity against Saccharomyces cerevisiae BY4741 after 24 hrs by broth microdilution method | 2015 | Journal of natural products, Jan-23, Volume: 78, Issue:1 | Structure and antimicrobial activity of phloroglucinol derivatives from Achyrocline satureioides. |
| AID95884 | Antibacterial activity expressed as MIC value was determined on Klebsiella pneumonia A-20468 organism | 1986 | Journal of medicinal chemistry, May, Volume: 29, Issue:5 | Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin. |
| AID278250 | Antimicrobial activity against Salmonella enterica serovar Typhimurium CS1 acrAB::Kan with GyrA S83F, D87N, ParC S80I mutation | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials. |
| AID556562 | Antimicrobial activity against sodA gene-deficient Escherichia coli K-12 3144 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Contribution of oxidative damage to antimicrobial lethality. |
| AID1585461 | Antibacterial activity against erythromycin-resistant Staphylococcus aureus NRS-70 measured after 16 hrs | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Design, synthesis and evaluation of hybrid of tetrahydrocarbazole with 2,4-diaminopyrimidine scaffold as antibacterial agents. |
| AID523405 | Antimicrobial activity against amikacin-susceptible Nocardia farcinica IFM 10152 after 3 days by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Homozygous triplicate mutations in three 16S rRNA genes responsible for high-level aminoglycoside resistance in Nocardia farcinica clinical isolates from a Canada-wide bovine mastitis epizootic. |
| AID563503 | Antimicrobial activity against cetylpyridinium chloride-sensitive Serratia marcescens 79 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Mutational upregulation of a resistance-nodulation-cell division-type multidrug efflux pump, SdeAB, upon exposure to a biocide, cetylpyridinium chloride, and antibiotic resistance in Serratia marcescens. |
| AID625280 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cholecystitis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID1079941 | Liver damage due to vascular disease: peliosis hepatitis, hepatic veno-occlusive disease, Budd-Chiari syndrome. Value is number of references indexed. [column 'VASC' in source] | |||
| AID771495 | Antibacterial activity against Pseudomonas aeruginosa by dilution technique | 2013 | European journal of medicinal chemistry, Oct, Volume: 68 | Synthesis and biological evaluation of novel ocotillol-type triterpenoid derivatives as antibacterial agents. |
| AID1250525 | Antibacterial activity against Pseudomonas aeruginosa ATCC 9027 after 24 hr by MTT assay | 2015 | European journal of medicinal chemistry, Sep-18, Volume: 102 | Synthesis and evaluation of new tyrosyl-tRNA synthetase inhibitors as antibacterial agents based on a N2-(arylacetyl)glycinanilide scaffold. |
| AID424589 | Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH370 (SCV-42) harboring TAA stop codon at nucleotide 229 in rplF gene after 18 to 24 hrs by Etest strip assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID164253 | Antibacterial activity expressed as MIC value was determined on Pseudomonas aeruginosa A-20741 organism | 1986 | Journal of medicinal chemistry, May, Volume: 29, Issue:5 | Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin. |
| AID424335 | Antibacterial activity against fusidic acid-susceptible wild type Staphylococcus aureus 8325-4 after 18 to 24 hrs by Etest strip assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID490134 | Antibacterial activity against Bacillus subtilis ATCC 6633 after 24 hrs by MTT assay | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Synthesis of some N-alkyl substituted urea derivatives as antibacterial and antifungal agents. |
| AID278805 | Antimicrobial activity against Stenotrophomonas maltophilia K279a mutant | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Aph(3')-IIc, an aminoglycoside resistance determinant from Stenotrophomonas maltophilia. |
| AID68018 | Antibacterial activity expressed as MIC value was determined on Enterobacter cloacae A-9656 organism | 1986 | Journal of medicinal chemistry, May, Volume: 29, Issue:5 | Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin. |
| AID424611 | Antibacterial activity against kanamycin-resistant and fusidic acid-susceptible Staphylococcus aureus AH288 harboring Gly617Asp mutation in fusA gene after 18 to 24 hrs by Etest strip assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID1695859 | Antibacterial activity against Staphylococcus aureus ATCC 29737 incubated for 24 hrs | 2019 | European journal of medicinal chemistry, Apr-15, Volume: 168 | Comprehensive review on the anti-bacterial activity of 1,2,3-triazole hybrids. |
| AID520869 | Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus saprophyticus isolate TSU33 isolated from genitourinary tracts of acute cystitis patient after 24 hrs at 35 degC by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Methicillin-resistant Staphylococcus saprophyticus isolates carrying staphylococcal cassette chromosome mec have emerged in urogenital tract infections. |
| AID524389 | Antibacterial activity against Escherichia coli NKE1367 harboring deletion mutation in acrB, mdtABC protein and plasmid expressing nlpE gene | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Effect of NlpE overproduction on multidrug resistance in Escherichia coli. |
| AID1432500 | Antibacterial activity against Bacillus subtilis NBRC 3134 after overnight incubation by MTT assay | 2017 | Bioorganic & medicinal chemistry letters, 03-15, Volume: 27, Issue:6 | Filamenting temperature-sensitive mutant Z inhibitors from Glycyrrhiza glabra and their inhibitory mode of action. |
| AID1265790 | Antibacterial activity against Staphylococcus aureus NRS382 (USA 100) by microdilution method | 2015 | Journal of medicinal chemistry, Dec-10, Volume: 58, Issue:23 | Synthesis and Bioactivities of Kanamycin B-Derived Cationic Amphiphiles. |
| AID325444 | Antibacterial activity against Escherichia coli K12 after 14 to 16 hrs by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Polyamine effects on antibiotic susceptibility in bacteria. |
| AID428869 | Antibacterial activity against Escherichia coli isolate ARS3 carrying pARS3 by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Novel plasmid-mediated 16S rRNA m1A1408 methyltransferase, NpmA, found in a clinically isolated Escherichia coli strain resistant to structurally diverse aminoglycosides. |
| AID544273 | Antimicrobial activity against Enterococcus faecalis NKH3 harboring pMG2200-like and pMG2201-like plasmids after 24 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Isolation of VanB-type Enterococcus faecalis strains from nosocomial infections: first report of the isolation and identification of the pheromone-responsive plasmids pMG2200, Encoding VanB-type vancomycin resistance and a Bac41-type bacteriocin, and pMG2 |
| AID1493076 | Antibacterial activity against vancomycin-resistant Enterococcus faecium 7 by dilution susceptibility test | 2017 | Journal of natural products, 11-22, Volume: 80, Issue:11 | Antibacterial 3,6-Disubstituted 4-Hydroxy-5,6-dihydro-2H-pyran-2-ones from Serratia plymuthica MF371-2. |
| AID1413333 | Antifungal activity against Candida albicans B-311 | 2018 | MedChemComm, Jun-01, Volume: 9, Issue:6 | Antifungal amphiphilic kanamycins: new life for an old drug. |
| AID164371 | Antibacterial activity expressed as MIC value was determined on Pseudomonas aeruginosa A-22233 organism | 1986 | Journal of medicinal chemistry, May, Volume: 29, Issue:5 | Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin. |
| AID368423 | Antimicrobial activity against Escherichia coli KAM32 pSTVdeltaqepA containing disrupted qepA gene by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | New plasmid-mediated fluoroquinolone efflux pump, QepA, found in an Escherichia coli clinical isolate. |
| AID535769 | Antimicrobial activity against Mycobacterium ulcerans ATCC 19423 agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Rapid assessment of antibacterial activity against Mycobacterium ulcerans by using recombinant luminescent strains. |
| AID523396 | Antimicrobial activity against amikacin-resistant Nocardia farcinica IFM 10580 after 3 days by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Homozygous triplicate mutations in three 16S rRNA genes responsible for high-level aminoglycoside resistance in Nocardia farcinica clinical isolates from a Canada-wide bovine mastitis epizootic. |
| AID574803 | Antimycobacterial activity against extensively drug-resistant Mycobacterium tuberculosis isolate 2474 obtained from sputum of patient at 4 ug/ml by Bactec MGIT960 modified proportion method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Emergence and molecular characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates from the Delhi Region in India. |
| AID510749 | Antibacterial activity against Escherichia coli AG102MB harboring pP10-based acrB gene | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Single nucleotide polymorphism analysis of the major tripartite multidrug efflux pump of Escherichia coli: functional conservation in disparate animal reservoirs despite exposure to antimicrobial chemotherapy. |
| AID1562312 | Antimycobacterial activity against Mycobacterium smegmatis atR14 assessed as decrease in drug resistance development at 5 ug/disc after 2 to 3 days by paper disc method | 2019 | European journal of medicinal chemistry, Sep-15, Volume: 178 | Synthesis and antimycobacterial activity of imidazo[1,2-b][1,2,4,5]tetrazines. |
| AID424572 | Antibacterial activity against kanamycin-susceptible wild type Staphylococcus aureus AH001 after 18 to 24 hrs by Etest strip assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID290123 | Inhibition of protein synthesis in Escherichia coli by coupled transcription-translation assay | 2007 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 17, Issue:5 | Synthesis and SAR of 3,5-diamino-piperidine derivatives: novel antibacterial translation inhibitors as aminoglycoside mimetics. |
| AID619545 | Antibacterial activity against Bacillus subtilis ATCC 6633 after 24 hrs by MTT assay | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10 | Tyrosyl-tRNA synthetase inhibitors as antibacterial agents: synthesis, molecular docking and structure-activity relationship analysis of 3-aryl-4-arylaminofuran-2(5H)-ones. |
| AID556566 | Antimicrobial activity against ahpC gene-deficient Escherichia coli K-12 3200 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Contribution of oxidative damage to antimicrobial lethality. |
| AID534339 | Antimicrobial activity against Burkholderia pseudomallei 1026b after 24 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | The BpeAB-OprB efflux pump of Burkholderia pseudomallei 1026b does not play a role in quorum sensing, virulence factor production, or extrusion of aminoglycosides but is a broad-spectrum drug efflux system. |
| AID574807 | Antimycobacterial activity against extensively drug-resistant Mycobacterium tuberculosis isolate 761 horboring rpoB S531L/Q510P, katG S315T/R463L, gyrA D94N/S95T, rrs G1484T by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Emergence and molecular characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates from the Delhi Region in India. |
| AID1566490 | Inhibition of Dicer mediated biotinylated pre-miRNA-21 (unknown origin) maturation at 1 mM measured after 15 mins by cat-ELCCA relative to control | 2019 | ACS medicinal chemistry letters, May-09, Volume: 10, Issue:5 | Tetracyclines as Inhibitors of Pre-microRNA Maturation: A Disconnection between RNA Binding and Inhibition. |
| AID625925 | Antibacterial activity against Pseudomonas aeruginosa by micro-broth dilution method | 2011 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 21, Issue:21 | Micelles catalyzed chemoselective synthesis 'in water' and biological evaluation of oxygen containing hetero-1,4-naphthoquinones as potential antifungal agents. |
| AID1852754 | Antibacterial activity against wild type Escherichia coli ATCC 25922 assessed as bacterial growth inhibition by broth microdilution assay | 2022 | RSC medicinal chemistry, Sep-21, Volume: 13, Issue:9 | Design and evaluation of poly-nitrogenous adjuvants capable of potentiating antibiotics in Gram-negative bacteria. |
| AID1738320 | Antibacterial activity against multidrug-resistant Staphylococcus aureus NRS1 assessed as reduction in bacterial growth incubated for 16 to 18 hrs by two fold serial dilution method | 2020 | European journal of medicinal chemistry, Jul-15, Volume: 198 | Capsaicin derivatives with nitrothiophene substituents: Design, synthesis and antibacterial activity against multidrug-resistant S. aureus. |
| AID521582 | Antibacterial activity against Salmonella enterica serovars Typhimurium ATCC 14028 infected in mouse J774A.1 cells at 50 ug/ml after 1hr | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Aminoglycosides affect intracellular Salmonella enterica serovars typhimurium and virchow. |
| AID283533 | Antibacterial activity against Pseudomonas aeruginosa FE57 with inactivated rplY gene by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides. |
| AID69758 | Antibacterial activity expressed as MIC value was determined on Escherichia coli A-22356 organism | 1986 | Journal of medicinal chemistry, May, Volume: 29, Issue:5 | Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin. |
| AID428871 | Antibacterial activity against Escherichia coli CSH-2 by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Novel plasmid-mediated 16S rRNA m1A1408 methyltransferase, NpmA, found in a clinically isolated Escherichia coli strain resistant to structurally diverse aminoglycosides. |
| AID1164940 | Antimicrobial activity against Mycobacterium tuberculosis H37Rv by microbroth dilution method | 2014 | Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20 | Synthesis, structure-activity relationship studies, and antibacterial evaluation of 4-chromanones and chalcones, as well as olympicin A and derivatives. |
| AID1562309 | Antimycobacterial activity against Mycobacterium smegmatis atR11 assessed as decrease in drug resistance development at 5 ug/disc after 2 to 3 days by paper disc method | 2019 | European journal of medicinal chemistry, Sep-15, Volume: 178 | Synthesis and antimycobacterial activity of imidazo[1,2-b][1,2,4,5]tetrazines. |
| AID524392 | Antibacterial activity against Escherichia coli NKE1369 harboring deletion mutation in acrB, acrD, mdtABC protein and plasmid expressing nlpE gene | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Effect of NlpE overproduction on multidrug resistance in Escherichia coli. |
| AID1765577 | Antibacterial activity against Escherichia coli ATCC 25922 incubated for 18 hrs by CLSI based broth dilution method | 2021 | Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15 | Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice. |
| AID584326 | Antibacterial activity against tolC deficient Escherichia coli GD100 | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics. |
| AID257553 | Antibacterial activity against Pseudomonas aeruginosa | 2005 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 15, Issue:23 | Synthesis and biological evaluation of novel (L)-alpha-amino acid methyl ester, heteroalkyl, and aryl substituted 1,4-naphthoquinone derivatives as antifungal and antibacterial agents. |
| AID1638885 | Antimicrobial activity against Bacillus subtilis at 0.5 to 256 ug/ml after 24 hrs by two-fold serial micro dilution method | 2019 | Journal of natural products, 04-26, Volume: 82, Issue:4 | Inducing Secondary Metabolite Production by Co-culture of the Endophytic Fungus Phoma sp. and the Symbiotic Fungus Armillaria sp. |
| AID424612 | Antibacterial activity against kanamycin-resistant and fusidic acid-susceptible Staphylococcus aureus AH294 harboring Gly628Val mutation in fusA gene after 18 to 24 hrs by Etest strip assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID278243 | Antimicrobial activity against Salmonella enterica serovar Typhimurium S21-3 tolC::Kan with GyrA S83F, ParC S80I mutation | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials. |
| AID420209 | Antimicrobial activity against Serratia marcescens UFPEDA 398 at 30 ug/disk after 24 hrs by disk diffusion method | 2009 | European journal of medicinal chemistry, May, Volume: 44, Issue:5 | Synthesis, antimicrobial and cytotoxic activities of some 5-arylidene-4-thioxo-thiazolidine-2-ones. |
| AID565418 | Antimicrobial activity against Salmonella enterica serotype Stanley isolate AM04864 expressing armA rRNA methyltransferase gene by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | Identification of the aminoglycoside resistance determinants armA and rmtC among non-Typhi Salmonella isolates from humans in the United States. |
| AID1293901 | Antibacterial activity against Bacillus subtilis after 18 hrs by broth dilution method | 2016 | Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9 | Novel tetrazoloquinoline-rhodanine conjugates: Highly efficient synthesis and biological evaluation. |
| AID470061 | Antibacterial activity against Mycobacterium smegmatis after 3 days by broth microdilution method | 2009 | Journal of natural products, Nov, Volume: 72, Issue:11 | Bioactive constituents of the stem bark of Mitrephora glabra. |
| AID1132236 | Antibacterial activity against drug-sensitive Proteus vulgaris 838 assessed as growth inhibition by agar dilution method | 1978 | Journal of medicinal chemistry, Feb, Volume: 21, Issue:2 | Chemical modification of 1,4-diamino-1,4-dideoxy-3-O-(4-deoxy-4-propionamido-alpha-D-glucopyranosyl)-D-glucitol. |
| AID1593377 | Inhibition of Pks13 D1644G/N1640K double mutant thioesterase domain in extensively drug-resistant Mycobacterium tuberculosis R506 assessed as reduction in bacterial growth by microplate alamar blue assay | 2019 | Journal of medicinal chemistry, 04-11, Volume: 62, Issue:7 | Identification of Novel Coumestan Derivatives as Polyketide Synthase 13 Inhibitors against Mycobacterium tuberculosis. Part II. |
| AID584337 | Antibacterial activity against tolC deficient Escherichia coli GD100 absence of glutathione | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics. |
| AID718270 | Antimicrobial activity against Escherichia coli ATCC 25922 | 2012 | Journal of natural products, Dec-28, Volume: 75, Issue:12 | Marthiapeptide A, an anti-infective and cytotoxic polythiazole cyclopeptide from a 60 L scale fermentation of the deep sea-derived Marinactinospora thermotolerans SCSIO 00652. |
| AID1132224 | Antibacterial activity against streptomycin, neomycin, kanamycin-resistant Staphylococcus aureus 2314 assessed as growth inhibition by agar dilution method | 1978 | Journal of medicinal chemistry, Feb, Volume: 21, Issue:2 | Chemical modification of 1,4-diamino-1,4-dideoxy-3-O-(4-deoxy-4-propionamido-alpha-D-glucopyranosyl)-D-glucitol. |
| AID425072 | Antimicrobial activity against Escherichia coli DH10B expressing pCRQB10 in presence of IPTG | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Complex class 1 integrons with diverse variable regions, including aac(6')-Ib-cr, and a novel allele, qnrB10, associated with ISCR1 in clinical enterobacterial isolates from Argentina. |
| AID1510726 | Antibacterial activity against Escherichia coli | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Nitroimidazole-containing compounds and their antibacterial and antitubercular activities. |
| AID424832 | Ratio of MIC for kanamycin-resistant Staphylococcus aureus harboring mutations in FusE gene to MIC for wild type kanamycin-susceptible Staphylococcus aureus AH001 | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID1079949 | Proposed mechanism(s) of liver damage. [column 'MEC' in source] | |||
| AID424600 | Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH384 (SCV-56) harboring -1 frameshift mutation at nucleotide 221 in rplF gene after 18 to 24 hrs by Etest strip assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID285339 | Antimicrobial activity against streptomycin-resistant Escherichia coli J53 by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | First report of plasmid-mediated qnrA1 in a ciprofloxacin-resistant Escherichia coli strain in Latin America. |
| AID1478523 | Antibacterial activity against aminoglycosides-susceptible Escherichia coli R477-100 by double microdilution method | 2017 | Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11 | Covalently linked kanamycin - Ciprofloxacin hybrid antibiotics as a tool to fight bacterial resistance. |
| AID1593386 | Growth inhibition of Escherichia coli AB1157 | 2019 | Journal of medicinal chemistry, 04-11, Volume: 62, Issue:7 | Identification of Novel Coumestan Derivatives as Polyketide Synthase 13 Inhibitors against Mycobacterium tuberculosis. Part II. |
| AID521595 | Antibacterial activity against Salmonella enterica serovars virchow isolate 101591 at pH 7.0 by bioluminescence assay | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Aminoglycosides affect intracellular Salmonella enterica serovars typhimurium and virchow. |
| AID278534 | Antimicrobial activity against 60 min 1 M HCl-stressed Bifidobacterium animalis ATCC 27536 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID290146 | Antibacterial activity against Pseudomonas fluorescens after 24 hrs by MTT colorimetric method | 2007 | European journal of medicinal chemistry, Apr, Volume: 42, Issue:4 | Synthesis and antimicrobial activities of Schiff bases derived from 5-chloro-salicylaldehyde. |
| AID1887297 | Antibacterial activity against Staphylococcus aureus ATCC 25923 assessed as inhibition of bacterial growth incubated for 24 hrs by optical density based analysis | 2022 | Journal of natural products, 09-23, Volume: 85, Issue:9 | Total Syntheses and Antibacterial Evaluations of Neocyclomorusin and Related Flavones. |
| AID424606 | Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH330 (SCV-2) harboring -1 frameshift mutation at nucleotide 423 in rplF gene after 18 to 24 hrs by Etest strip assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID486726 | Antibacterial activity against Pseudomonas fluorescens ATCC 13525 after 24 hrs by MTT assay | 2010 | European journal of medicinal chemistry, Jun, Volume: 45, Issue:6 | Synthesis, structure and structure-activity relationship analysis of caffeic acid amides as potential antimicrobials. |
| AID278529 | Antimicrobial activity against Bifidobacterium longum R0175 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID1265788 | Antibacterial activity against Mycobacterium smegmatis MC2 155 by microdilution method | 2015 | Journal of medicinal chemistry, Dec-10, Volume: 58, Issue:23 | Synthesis and Bioactivities of Kanamycin B-Derived Cationic Amphiphiles. |
| AID1413325 | Antifungal activity against Cryptococcus neoformans 94-2586 | 2018 | MedChemComm, Jun-01, Volume: 9, Issue:6 | Antifungal amphiphilic kanamycins: new life for an old drug. |
| AID1176777 | Antimicrobial activity against Enterococcus faecalis ATCC 29212 after 24 hrs by broth microdilution method | 2015 | Journal of natural products, Jan-23, Volume: 78, Issue:1 | Structure and antimicrobial activity of phloroglucinol derivatives from Achyrocline satureioides. |
| AID1557267 | Antitubercular activity against resistant Mycobacterium tuberculosis harboring rrs G37T mutant after 3 to 6 weeks | 2019 | MedChemComm, Aug-01, Volume: 10, Issue:8 | Drug-resistance in |
| AID540932 | Antimicrobial activity against paromomycin-resistant Streptomyces coelicolor SP2 harboring rpsL K88E mutant gene and inserted glycine at position 92 of the gene after 48 hrs | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | A novel insertion mutation in Streptomyces coelicolor ribosomal S12 protein results in paromomycin resistance and antibiotic overproduction. |
| AID584116 | Ratio of MIC for Escherichia coli KAM32 harboring cloned pSP72 lmrS to MIC for Escherichia coli KAM32 harboring pSP72 | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | LmrS is a multidrug efflux pump of the major facilitator superfamily from Staphylococcus aureus. |
| AID534346 | Antimicrobial activity against Burkholderia pseudomallei Bp207 harboring deleted (bpeAB-oprA)::FRT gene after 24 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | The BpeAB-OprB efflux pump of Burkholderia pseudomallei 1026b does not play a role in quorum sensing, virulence factor production, or extrusion of aminoglycosides but is a broad-spectrum drug efflux system. |
| AID532982 | Antibacterial activity against Escherichia coli W3110 in presence of 10 mM N-Acetylcysteine | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | N-acetylcysteine-mediated modulation of bacterial antibiotic susceptibility. |
| AID1510727 | Antibacterial activity against Pseudomonas aeruginosa | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Nitroimidazole-containing compounds and their antibacterial and antitubercular activities. |
| AID278532 | Antimicrobial activity against Bifidobacterium thermophilum ATCC 25866 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID1565714 | Antifungal activity against Cryptococcus neoformans VR-54 incubated for 24 to 36 hrs by two fold dilution method | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Scalable and cost-effective tosylation-mediated synthesis of antifungal and fungal diagnostic 6″-Modified amphiphilic kanamycins. |
| AID278551 | Antimicrobial activity against 90 mins oxgall-stressed Bifidobacterium infantis ATCC 15697 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID424340 | Antibacterial activity against fusidic acid-resistant Staphylococcus aureus AH201 harboring Gly452Cys mutation in fusA after 18 to 24 hrs by Etest strip assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID1337844 | Antifungal activity against Aspergillus flavus NCIM 539 by standard agar method | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Quinolidene-rhodanine conjugates: Facile synthesis and biological evaluation. |
| AID1510725 | Antibacterial activity against Bacillus subtilis | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Nitroimidazole-containing compounds and their antibacterial and antitubercular activities. |
| AID1478544 | Antibacterial activity against Bacillus subtilis ATCC 6633 in 15th subculture in presence of equimolar concentration of ciprofloxacin by double microdilution method | 2017 | Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11 | Covalently linked kanamycin - Ciprofloxacin hybrid antibiotics as a tool to fight bacterial resistance. |
| AID374112 | Antimicrobial activity against azide-resistant aac(6')-Ib-cr expressing Escherichia coli J53 qnrA1 bearing pHS6 transconjugant from Escherichia coli 650 by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Prevalence and expression of the plasmid-mediated quinolone resistance determinant qnrA1. |
| AID424339 | Antibacterial activity against fusidic acid-resistant Staphylococcus aureus AH198 harboring Gly452Ser mutation in fusA gene after 18 to 24 hrs by Etest strip assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID1132225 | Antibacterial activity against drug-sensitive Bacillus subtilis 964 assessed as growth inhibition by agar dilution method | 1978 | Journal of medicinal chemistry, Feb, Volume: 21, Issue:2 | Chemical modification of 1,4-diamino-1,4-dideoxy-3-O-(4-deoxy-4-propionamido-alpha-D-glucopyranosyl)-D-glucitol. |
| AID1868109 | Antibacterial activity against Pseudomonas aeruginosa ATCC 9027 assessed as inhibition of visible bacterial growth incubated for 18 hrs by CLSI protocol based assay | 2022 | Journal of natural products, 05-27, Volume: 85, Issue:5 | Enceleamycins A-C, Furo-Naphthoquinones from |
| AID774297 | Antimycobacterial activity against isoniazid-resistant Mycobacterium tuberculosis ATCC 35822 | 2013 | Journal of natural products, Oct-25, Volume: 76, Issue:10 | Chlorinated coumarins from the polypore mushroom Fomitopsis officinalis and their activity against Mycobacterium tuberculosis. |
| AID364063 | Antibacterial activity against Pseudomonas fluorescens ATCC 13525 after 24 hrs by MTT assay | 2008 | European journal of medicinal chemistry, Sep, Volume: 43, Issue:9 | Enamines as novel antibacterials and their structure-activity relationships. |
| AID560598 | Antimicrobial activity against Escherichia coli JM109 transformant harboring pSTV28 plasmid by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | AAC(6')-Iaf, a novel aminoglycoside 6'-N-acetyltransferase from multidrug-resistant Pseudomonas aeruginosa clinical isolates. |
| AID278249 | Antimicrobial activity against Salmonella enterica serovar Typhimurium CS1 gyrA+ with GyrA S83F, D87N, ParC S80I mutation | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials. |
| AID1413321 | Antibacterial activity against Escherichia coli TG1 | 2018 | MedChemComm, Jun-01, Volume: 9, Issue:6 | Antifungal amphiphilic kanamycins: new life for an old drug. |
| AID1265792 | Antibacterial activity against Staphylococcus aureus NRS385 (USA 300) by microdilution method | 2015 | Journal of medicinal chemistry, Dec-10, Volume: 58, Issue:23 | Synthesis and Bioactivities of Kanamycin B-Derived Cationic Amphiphiles. |
| AID1413315 | Antifungal activity against Cryptococcus neoformans 90-26 | 2018 | MedChemComm, Jun-01, Volume: 9, Issue:6 | Antifungal amphiphilic kanamycins: new life for an old drug. |
| AID524383 | Antibacterial activity against Escherichia coli NKE161 harboring deletion mutation in acrB protein, vector expressing tolC gene and plasmid expressing nlpE gene | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Effect of NlpE overproduction on multidrug resistance in Escherichia coli. |
| AID69757 | Antibacterial activity expressed as MIC value was determined on Escherichia coli A-9632 organism | 1986 | Journal of medicinal chemistry, May, Volume: 29, Issue:5 | Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin. |
| AID1228001 | Antibacterial activity against Staphylococcus aureus isolated from tibial osteomyelitis patient assessed as inhibition of visible bacterial growth incubated for 24 hrs at 37 degC by broth microdilution method | 2015 | Journal of natural products, Apr-24, Volume: 78, Issue:4 | Antibacterial Polyketide Heterodimers from Pyrenacantha kaurabassana Tubers. |
| AID1132239 | Antibacterial activity against drug-sensitive Escherichia coli 60 assessed as growth inhibition by agar dilution method | 1978 | Journal of medicinal chemistry, Feb, Volume: 21, Issue:2 | Chemical modification of 1,4-diamino-1,4-dideoxy-3-O-(4-deoxy-4-propionamido-alpha-D-glucopyranosyl)-D-glucitol. |
| AID1852779 | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv assessed as inhibition of bacterial growth for 5 weeks by spot culture growth inhibition assay | 2022 | RSC medicinal chemistry, Nov-16, Volume: 13, Issue:11 | Synthesis, biological evaluation and computational studies of pyrazole derivatives as |
| AID278522 | Antimicrobial activity against Bifidobacterium bifidum R0071 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID69629 | Minimum inhibitory concentration was measured against Escherichia coli A 20665 | 1980 | Journal of medicinal chemistry, Jan, Volume: 23, Issue:1 | Aminoglycoside antibiotics. 3. Epimino derivatives of neamine, ribostamycin, and kanamycin B. |
| AID1455939 | Antifungal activity against Trichophyton mentagrophytes after 96 hrs by broth micro-dilution method | 2017 | Journal of natural products, 02-24, Volume: 80, Issue:2 | Nabscessins A and B, Aminocyclitol Derivatives from Nocardia abscessus IFM 10029 |
| AID278566 | Antimicrobial activity against 90 mins hydrogen peroxide-stressed Bifidobacterium longum P/N 601377 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID584115 | Antibacterial activity against Escherichia coli KAM32 harboring pSP72 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | LmrS is a multidrug efflux pump of the major facilitator superfamily from Staphylococcus aureus. |
| AID275055 | Antibacterial activity against Escherichia coli pTMV19 | 2006 | Journal of medicinal chemistry, Dec-14, Volume: 49, Issue:25 | Isoprenoid biosynthesis as a drug target: bisphosphonate inhibition of Escherichia coli K12 growth and synergistic effects of fosmidomycin. |
| AID551745 | Antibacterial activity against Escherichia coli ATCC 25922 after 12 to 18 hrs by twofold dilution method | 2011 | Bioorganic & medicinal chemistry, Jan-01, Volume: 19, Issue:1 | Synthesis and antibacterial activity study of a novel class of cationic anthraquinone analogs. |
| AID69753 | Antibacterial activity expressed as MIC value was determined on Escherichia coli A-20895 organism | 1986 | Journal of medicinal chemistry, May, Volume: 29, Issue:5 | Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin. |
| AID749378 | Antimicrobial activity against Escherichia coli ATCC 25922 after 24 hrs by two fold serial dilution method | 2013 | Bioorganic & medicinal chemistry, Jun-01, Volume: 21, Issue:11 | Design, synthesis and antimicrobial activities evaluation of Schiff base derived from secnidazole derivatives as potential FabH inhibitors. |
| AID163265 | Minimum inhibitory concentration was measured against Pseudomonas aeruginosa A 20653 | 1980 | Journal of medicinal chemistry, Jan, Volume: 23, Issue:1 | Aminoglycoside antibiotics. 3. Epimino derivatives of neamine, ribostamycin, and kanamycin B. |
| AID278251 | Antimicrobial activity against Salmonella enterica serovar Typhimurium CS1 tolC::Kan with GyrA S83F, D87N, ParC S80I mutation | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials. |
| AID381843 | Antibacterial activity against Pseudomonas fluorescens ATCC 13525 | 2008 | Bioorganic & medicinal chemistry, Apr-01, Volume: 16, Issue:7 | Synthesis, structure and antibacterial activity of novel 1-(5-substituted-3-substituted-4,5-dihydropyrazol-1-yl)ethanone oxime ester derivatives. |
| AID424338 | Antibacterial activity against fusidic acid-resistant Staphylococcus aureus AH196 harboring Pro406Leu mutation in fusA gene after 18 to 24 hrs by Etest strip assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID283539 | Antibacterial activity against Pseudomonas aeruginosa FE57G with inactivated rplY and nuoG genes by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides. |
| AID520871 | Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus saprophyticus isolate TSU57 isolated from genitourinary tracts of acute cystitis patient after 24 hrs at 35 degC by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Methicillin-resistant Staphylococcus saprophyticus isolates carrying staphylococcal cassette chromosome mec have emerged in urogenital tract infections. |
| AID544281 | Antimicrobial activity against Enterococcus faecalis NKH11 harboring pMG2200-like plasmid after 24 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Isolation of VanB-type Enterococcus faecalis strains from nosocomial infections: first report of the isolation and identification of the pheromone-responsive plasmids pMG2200, Encoding VanB-type vancomycin resistance and a Bac41-type bacteriocin, and pMG2 |
| AID368422 | Antimicrobial activity against Escherichia coli KAM32 pSTVqepA containing qepA gene ligated to pSTV28 plasmid by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | New plasmid-mediated fluoroquinolone efflux pump, QepA, found in an Escherichia coli clinical isolate. |
| AID1271381 | Antimicrobial activity against Gram-positive methicillin-resistant Staphylococcus aureus 1 after 16 to 24 hrs by micro-dilution method | 2015 | ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11 | Synthesis and Biological Activity of Mono- and Di-N-acylated Aminoglycosides. |
| AID765041 | Antibacterial activity against Staphylococcus aureus ATCC 25923 by MTT assay | 2013 | Bioorganic & medicinal chemistry, Sep-01, Volume: 21, Issue:17 | 3-Aryl-4-acyloxyethoxyfuran-2(5H)-ones as inhibitors of tyrosyl-tRNA synthetase: synthesis, molecular docking and antibacterial evaluation. |
| AID1565718 | Antibacterial activity against Staphylococcus aureus ATCC 25923 incubated for 18 hrs by two fold dilution method | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Scalable and cost-effective tosylation-mediated synthesis of antifungal and fungal diagnostic 6″-Modified amphiphilic kanamycins. |
| AID425069 | Antimicrobial activity against multidrug-resistant Klebsiella pneumoniae M7943 bearing qnrB10 gene with aac(6)-Ib-cr-blaOXA-30 catB3-arr-3 integron in presence of IPTG | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Complex class 1 integrons with diverse variable regions, including aac(6')-Ib-cr, and a novel allele, qnrB10, associated with ISCR1 in clinical enterobacterial isolates from Argentina. |
| AID584338 | Antibacterial activity against tolC deficient Escherichia coli GD100 presence of 5 mM of glutathione | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics. |
| AID278261 | Antimicrobial activity against Salmonella enterica serovar Typhimurium CHS14 gyrA+ with GyrA D87G mutation | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials. |
| AID1478537 | Inhibition of Escherichia coli topoisomerase 4 using supercoiled pBR322 DNA as substrate by agarose gel electrophorosis method | 2017 | Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11 | Covalently linked kanamycin - Ciprofloxacin hybrid antibiotics as a tool to fight bacterial resistance. |
| AID1906414 | Antibacterial activity against Methicillin resistant Staphylococcus aureus ATCC BAA -1556 assessed as reduction in microbial growth incubated for 24 hrs by microbroth dilution method | 2022 | European journal of medicinal chemistry, May-05, Volume: 235 | Amphiphilic cyclic peptide [W |
| AID445285 | Antibacterial activity against Mycobacterium bovis BCG str. Tokyo 172 by broth dilution method | 2009 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 19, Issue:22 | Synthesis of new sugar derivatives and evaluation of their antibacterial activities against Mycobacterium tuberculosis. |
| AID556753 | Bactericidal activity against sodB gene-deficient Escherichia coli K-12 3145 after 18 hrs | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Contribution of oxidative damage to antimicrobial lethality. |
| AID1879068 | Antibacterial activity against NDM-1 positive Escherichia coli ZC-YN3 isolates assessed as inhibition of bacterial growth incubated for 18 to 24 hrs by CLSI based broth microdilution method | 2022 | European journal of medicinal chemistry, Mar-05, Volume: 231 | Metallo-β-lactamases inhibitor fisetin attenuates meropenem resistance in NDM-1-producing Escherichia coli. |
| AID244899 | In-vitro minimum inhibitory concentration against the growth of Klebsiella pneumoniae | 2005 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 15, Issue:13 | Synthesis of (1,4)-naphthoquinono-[3,2-c]-1H-pyrazoles and their (1,4)-naphthohydroquinone derivatives as antifungal, antibacterial, and anticancer agents. |
| AID587760 | Antimicrobial activity against Mycobacterium ulcerans Mu1059 expressing luxAB from vibrio harveyi infected BALB/c mouse assessed as delay to time to foodpad swelling | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Using bioluminescence to monitor treatment response in real time in mice with Mycobacterium ulcerans infection. |
| AID1056537 | Antibacterial activity against Micrococcus luteus by broth microdilution method | 2013 | Journal of natural products, Dec-27, Volume: 76, Issue:12 | Cytotoxic and antibacterial marfuraquinocins from the deep South China Sea-derived Streptomyces niveus SCSIO 3406. |
| AID1868107 | Antibacterial activity against methicillin-resistant Staphylococcus aureus clinical isolate 10B assessed as inhibition of visible bacterial growth incubated for 18 hrs by CLSI protocol based assay | 2022 | Journal of natural products, 05-27, Volume: 85, Issue:5 | Enceleamycins A-C, Furo-Naphthoquinones from |
| AID381177 | Antibacterial activity against Escherichia coli after 24 to 72 hrs by disk diffusion method | 1999 | Journal of natural products, Sep, Volume: 62, Issue:9 | Antimicrobial and antitumor activities of mycosporulone. |
| AID510747 | Antibacterial activity against Escherichia coli AG102MB harboring pSport1-based acrB gene | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Single nucleotide polymorphism analysis of the major tripartite multidrug efflux pump of Escherichia coli: functional conservation in disparate animal reservoirs despite exposure to antimicrobial chemotherapy. |
| AID1413328 | Antifungal activity against Candida rugosa 95-967 | 2018 | MedChemComm, Jun-01, Volume: 9, Issue:6 | Antifungal amphiphilic kanamycins: new life for an old drug. |
| AID1593387 | Growth inhibition of Escherichia coli DH5[alpha] | 2019 | Journal of medicinal chemistry, 04-11, Volume: 62, Issue:7 | Identification of Novel Coumestan Derivatives as Polyketide Synthase 13 Inhibitors against Mycobacterium tuberculosis. Part II. |
| AID530286 | Antimicrobial activity against PR-39-resistant Salmonella enterica serovar Typhimurium LT2 DA10899 harboring Q179Stop mutant gene by Etest | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Mechanism and fitness costs of PR-39 resistance in Salmonella enterica serovar Typhimurium LT2. |
| AID1710568 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 assessed as reduction in bacterial growth at 64 uM incubated for 15 to 20 hrs by broth microdilution method relative to control | 2018 | MedChemComm, Jul-01, Volume: 9, Issue:7 | Targeting miRNA by tunable small molecule binders: peptidic aminosugar mediated interference in miR-21 biogenesis reverts epithelial to mesenchymal transition. |
| AID1869572 | Bactericidal activity against Acinetobacter baumannii DSM 300007 assessed as reduction in colony count and measured after 3 days by agar diffusion assay | 2022 | Journal of natural products, 06-24, Volume: 85, Issue:6 | Triculamin: An Unusual Lasso Peptide with Potent Antimycobacterial Activity. |
| AID278556 | Antimicrobial activity against 90 mins oxgall-stressed Bifidobacterium pseudolongum ATCC 25562 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID330983 | Antimicrobial activity against Pseudomonas aeruginosa 27853 | 2007 | Nature, May-03, Volume: 447, Issue:7140 | PTC124 targets genetic disorders caused by nonsense mutations. |
| AID1890919 | Antimicrobial activity against Staphylococcus aureus ATCC 51650 assessed as inhibition of microbial growth incubated for 16 hrs under shaking condition by microdilution assay | 2022 | Journal of natural products, 04-22, Volume: 85, Issue:4 | Expanding the Chemical Diversity of Fasamycin Via Genome Mining and Biocatalysis. |
| AID1303896 | Antibacterial activity against multidrug resistant Enterobacter cloacae subsp. cloacae CDC 442-68 (ATCC 13047) assessed as reduction in bacterial growth incubated for 6 to 8 hrs | 2016 | Bioorganic & medicinal chemistry letters, 07-01, Volume: 26, Issue:13 | GroEL/ES inhibitors as potential antibiotics. |
| AID290149 | Antifungal activity against Candida albicans after 48 hrs by MTT colorimetric method | 2007 | European journal of medicinal chemistry, Apr, Volume: 42, Issue:4 | Synthesis and antimicrobial activities of Schiff bases derived from 5-chloro-salicylaldehyde. |
| AID364061 | Antibacterial activity against Bacillus subtilis ATCC 6633 after 24 hrs by MTT assay | 2008 | European journal of medicinal chemistry, Sep, Volume: 43, Issue:9 | Enamines as novel antibacterials and their structure-activity relationships. |
| AID441923 | Antibacterial activity against Pseudomonas aeruginosa H45006 after 24 hrs by NCCLS method | 2009 | Journal of medicinal chemistry, Nov-12, Volume: 52, Issue:21 | Coordination chemistry based approach to lipophilic inhibitors of 1-deoxy-D-xylulose-5-phosphate reductoisomerase. |
| AID524264 | Antibacterial activity against Escherichia coli NKE158 harboring deletion mutation in acrB protein and vector expressing cpxAR gene | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Effect of NlpE overproduction on multidrug resistance in Escherichia coli. |
| AID725078 | Antimicrobial activity against Salmonella typhimurium after 12 to 18 hrs by micro-well dilution method | 2013 | European journal of medicinal chemistry, Jan, Volume: 59 | Synthesis and antibacterial and antifungal evaluation of some chalcone based sulfones and bisulfones. |
| AID364064 | Antibacterial activity against Staphylococcus aureus ATCC 6538 after 24 hrs by MTT assay | 2008 | European journal of medicinal chemistry, Sep, Volume: 43, Issue:9 | Enamines as novel antibacterials and their structure-activity relationships. |
| AID1428626 | Antibacterial activity against methicillin-resistant Staphylococcus aureus USA300 by broth microdilution method | 2017 | European journal of medicinal chemistry, Feb-15, Volume: 127 | Diaryltriazenes as antibacterial agents against methicillin resistant Staphylococcus aureus (MRSA) and Mycobacterium smegmatis. |
| AID551750 | Antibacterial activity against Enterococcus faecalis ATCC 29212 after 12 to 18 hrs by twofold dilution method | 2011 | Bioorganic & medicinal chemistry, Jan-01, Volume: 19, Issue:1 | Synthesis and antibacterial activity study of a novel class of cationic anthraquinone analogs. |
| AID441922 | Antibacterial activity against Escherichia coli B/r after 24 hrs by NCCLS method | 2009 | Journal of medicinal chemistry, Nov-12, Volume: 52, Issue:21 | Coordination chemistry based approach to lipophilic inhibitors of 1-deoxy-D-xylulose-5-phosphate reductoisomerase. |
| AID1262361 | Antibacterial activity against clinical isolates Proteus vulgaris after 24 hrs by agar diffusion assay | 2015 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 25, Issue:24 | PPL catalyzed four-component PASE synthesis of 5-monosubstituted barbiturates: Structure and pharmacological properties. |
| AID625290 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver fatty | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID1593385 | Growth inhibition of Bacillus subtilis 168 | 2019 | Journal of medicinal chemistry, 04-11, Volume: 62, Issue:7 | Identification of Novel Coumestan Derivatives as Polyketide Synthase 13 Inhibitors against Mycobacterium tuberculosis. Part II. |
| AID1056535 | Antibacterial activity against methicillin-resistant Staphylococcus epidermidis clinical isolate shhs-E1 by broth microdilution method | 2013 | Journal of natural products, Dec-27, Volume: 76, Issue:12 | Cytotoxic and antibacterial marfuraquinocins from the deep South China Sea-derived Streptomyces niveus SCSIO 3406. |
| AID1525090 | Antimicrobial activity against Mycobacterium smegmatis DSM 43524 by serial dilution assay | 2019 | Journal of natural products, 05-24, Volume: 82, Issue:5 | Sesquiterpenes from an Eastern African Medicinal Mushroom Belonging to the Genus Sanghuangporus. |
| AID585017 | Antibacterial activity against Mycobacterium smegmatis MC2 155 ATCC | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1 | Inhibition of bacterial multidrug resistance by celecoxib, a cyclooxygenase-2 inhibitor. |
| AID718273 | Antimicrobial activity against Bacillus subtilis ATCC 6633 | 2012 | Journal of natural products, Dec-28, Volume: 75, Issue:12 | Marthiapeptide A, an anti-infective and cytotoxic polythiazole cyclopeptide from a 60 L scale fermentation of the deep sea-derived Marinactinospora thermotolerans SCSIO 00652. |
| AID1418827 | Antibacterial activity against Pseudomonas aeruginosa at 1 mg/ml after 48 hrs by agar well diffusion method | 2018 | Bioorganic & medicinal chemistry, 11-15, Volume: 26, Issue:21 | Simplified lipid II-binding antimicrobial peptides: Design, synthesis and antimicrobial activity of bioconjugates of nisin rings A and B with pore-forming peptides. |
| AID1624150 | Antitubercular activity against isoniazid/ethionamide resistant Mycobacterium tuberculosis isolate 2 after 7 days | 2019 | European journal of medicinal chemistry, Feb-15, Volume: 164 | Synthesis and evaluation of α-aminoacyl amides as antitubercular agents effective on drug resistant tuberculosis. |
| AID574806 | Antimycobacterial activity against extensively drug-resistant Mycobacterium tuberculosis isolate 625 horboring rpoB S531L/G566R/I569L, katG S315T/R463L, gyrA A90V/S95T, rrs A1401G by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Emergence and molecular characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates from the Delhi Region in India. |
| AID1852760 | Antibacterial activity against Pseudomonas aeruginosa ATCC 9027 assessed as bacterial growth inhibition by broth microdilution assay | 2022 | RSC medicinal chemistry, Sep-21, Volume: 13, Issue:9 | Design and evaluation of poly-nitrogenous adjuvants capable of potentiating antibiotics in Gram-negative bacteria. |
| AID283540 | Antibacterial activity against Pseudomonas aeruginosa FE57Z with inactivated rplY and mexZ genes by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides. |
| AID424585 | Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH380 (SCV-52) harboring -1 frameshift mutation at nucleotide 158 in rplF gene after 18 to 24 hrs by Etest strip assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID486969 | Antibacterial activity against Escherichia coli after 24 hrs by micro broth dilution method | 2010 | European journal of medicinal chemistry, Jun, Volume: 45, Issue:6 | 'On water' assisted synthesis and biological evaluation of nitrogen and sulfur containing hetero-1,4-naphthoquinones as potent antifungal and antibacterial agents. |
| AID1055364 | Antibacterial activity against Pseudomonas aeruginosa after 18 hrs by turbidity assay | 2013 | Journal of natural products, Nov-22, Volume: 76, Issue:11 | Stereochemical assignment of the fungal metabolites pestalotiopsones D and E through enantiopure synthesis. |
| AID348959 | Antibacterial activity against Escherichia coli after 24 hrs by MTT assay | 2008 | European journal of medicinal chemistry, Jul, Volume: 43, Issue:7 | Synthesis and antimicrobial activities of 7-O-modified genistein derivatives. |
| AID1079936 | Choleostatic liver toxicity, either proven histopathologically or where the ratio of maximal ALT or AST activity above normal to that of Alkaline Phosphatase is < 2 (see ACUTE). Value is number of references indexed. [column 'CHOLE' in source] | |||
| AID1337799 | Antibacterial activity against Pseudomonas fluorescens NCIM 2036 measured after 8 hrs | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Quinolidene-rhodanine conjugates: Facile synthesis and biological evaluation. |
| AID759040 | Inhibition of Escherichia coli FabH overexpressed in Escherichia coli DH10B using holo-ACP as substrate after 1 min | 2013 | European journal of medicinal chemistry, Jul, Volume: 65 | Potentiating 1-(2-hydroxypropyl)-2-styryl-5-nitroimidazole derivatives against antibacterial agents: design, synthesis and biology analysis. |
| AID1176780 | Antimicrobial activity against Candida glabrata ATCC 9984 after 24 hrs by broth microdilution method | 2015 | Journal of natural products, Jan-23, Volume: 78, Issue:1 | Structure and antimicrobial activity of phloroglucinol derivatives from Achyrocline satureioides. |
| AID1177409 | Antibacterial activity against Bacillus cereus CMCC 63302 after 7 hrs by Alamar Blue assay | 2014 | Journal of natural products, Aug-22, Volume: 77, Issue:8 | Cytotoxic and Antibacterial Quinone Sesquiterpenes from a Myrothecium Fungus. |
| AID1617680 | Antibacterial activity against methicillin-resistant Staphylococcus aureus shhs-A1 by CLSI based two-fold serial dilution method | |||
| AID1306204 | Bactericidal activity against Escherichia coli ATCC 25922 after 18 hrs by microbroth dilution assay | 2016 | Bioorganic & medicinal chemistry, 07-15, Volume: 24, Issue:14 | The influence of halogen substituents on the biological properties of sulfur-containing flavonoids. |
| AID424609 | Antibacterial activity against kanamycin-resistant and fusidic acid-susceptible wild type Staphylococcus aureus 8325-4 clinical isolate after 18 to 24 hrs by Etest strip assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID1164946 | Antimicrobial activity against Klebsiella pneumoniae ATCC 33495 at >200 ug/ml by microbroth dilution method | 2014 | Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20 | Synthesis, structure-activity relationship studies, and antibacterial evaluation of 4-chromanones and chalcones, as well as olympicin A and derivatives. |
| AID278260 | Antimicrobial activity against Salmonella enterica serovar Typhimurium CHS14 with GyrA D87G mutation | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials. |
| AID1710569 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 1960649 assessed as reduction in bacterial growth at 64 uM incubated for 15 to 20 hrs by broth microdilution method relative to control | 2018 | MedChemComm, Jul-01, Volume: 9, Issue:7 | Targeting miRNA by tunable small molecule binders: peptidic aminosugar mediated interference in miR-21 biogenesis reverts epithelial to mesenchymal transition. |
| AID278258 | Antimicrobial activity against Salmonella enterica serovar Typhimurium CS9 acrAB::Kan with GyrA S83F, D87N, ParC S80I mutation | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials. |
| AID563500 | Antimicrobial activity against Serratia marcescens ATCC 13880 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Mutational upregulation of a resistance-nodulation-cell division-type multidrug efflux pump, SdeAB, upon exposure to a biocide, cetylpyridinium chloride, and antibiotic resistance in Serratia marcescens. |
| AID326541 | Antimicrobial activity against Mycobacterium abscessus R51 isolate after 3 to 5 days by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | In Vitro activities of isepamicin, other aminoglycosides, and capreomycin against clinical isolates of rapidly growing mycobacteria in Taiwan. |
| AID1326389 | Antibacterial activity against Bacillus subtilis P10B derived after 10 passage in presence of JBIR-100 after 16 to 18 hrs by microbroth dilution assay relative to Bacillus subtilis ATCC 47096 | 2016 | Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24 | Biological characterization of the hygrobafilomycin antibiotic JBIR-100 and bioinformatic insights into the hygrolide family of natural products. |
| AID1426251 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis ATCC 51299 | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | Synthesis and bioactivity investigation of quinone-based dimeric cationic triazolium amphiphiles selective against resistant fungal and bacterial pathogens. |
| AID1348089 | Antimicrobial activity against Bacillus subtilis subsp. subtilis ATCC 6051 assessed as zone of inhibition at 50 ug per disc after 24 hrs by disc diffusion assay | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Synthesis of new 1-benzyl tetrahydropyridinylidene ammonium salts and their antimicrobial and anticellular activities. |
| AID509448 | Antibacterial activity against Escherichia coli after 24 hrs by MTT assay | 2010 | European journal of medicinal chemistry, Sep, Volume: 45, Issue:9 | Design and synthesis of potent inhibitors of beta-ketoacyl-acyl carrier protein synthase III (FabH) as potential antibacterial agents. |
| AID1079943 | Malignant tumor, proven histopathologically. Value is number of references indexed. [column 'T.MAL' in source] | |||
| AID1562314 | Antimycobacterial activity against Mycobacterium smegmatis atR19 assessed as decrease in drug resistance development at 5 ug/disc after 2 to 3 days by paper disc method | 2019 | European journal of medicinal chemistry, Sep-15, Volume: 178 | Synthesis and antimycobacterial activity of imidazo[1,2-b][1,2,4,5]tetrazines. |
| AID1868105 | Antibacterial activity against methicillin-resistant Staphylococcus aureus clinical isolate 6B assessed as inhibition of visible bacterial growth incubated for 18 hrs by CLSI protocol based assay | 2022 | Journal of natural products, 05-27, Volume: 85, Issue:5 | Enceleamycins A-C, Furo-Naphthoquinones from |
| AID326545 | Antimicrobial activity against Mycobacterium abscessus R54 isolate after 3 to 5 days by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | In Vitro activities of isepamicin, other aminoglycosides, and capreomycin against clinical isolates of rapidly growing mycobacteria in Taiwan. |
| AID1299581 | Antibacterial activity against Escherichia coli ANS1 incubated overnight by microbroth dilution method | 2016 | Journal of medicinal chemistry, Apr-14, Volume: 59, Issue:7 | Antibacterial Diamines Targeting Bacterial Membranes. |
| AID565228 | Antimicrobial activity against Mycobacterium chelonae ATCC 35752 by resazurine microtiter assay | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Role of porins in the susceptibility of Mycobacterium smegmatis and Mycobacterium chelonae to aldehyde-based disinfectants and drugs. |
| AID1585463 | Antibacterial activity against gentamicin-resistant Staphylococcus aureus NRS-108 measured after 16 hrs | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Design, synthesis and evaluation of hybrid of tetrahydrocarbazole with 2,4-diaminopyrimidine scaffold as antibacterial agents. |
| AID1079934 | Highest frequency of acute liver toxicity observed during clinical trials, expressed as a percentage. [column '% AIGUE' in source] | |||
| AID647791 | Antibacterial activity Escherichia coli at 40 ug/disc after 24 hrs by agar disc diffusion method | 2012 | European journal of medicinal chemistry, Apr, Volume: 50 | Synthesis of new α aminophosphonate system bearing Indazole moiety and their biological activity. |
| AID144146 | Antibacterial activity against Mycobacterium kansasii | 1985 | Journal of medicinal chemistry, Dec, Volume: 28, Issue:12 | Synthesis and antibacterial activity of 2,2'-dithiobis(benzamide) derivatives against Mycobacterium species. |
| AID625281 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cholelithiasis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID424598 | Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH337 (SCV-9) harboring -1 frameshift mutation at nucleotide 220 in rplF gene after 18 to 24 hrs by Etest strip assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID534344 | Antimicrobial activity against Burkholderia pseudomallei Bp174 harboring mini-Tn7T-bpeR+ after 24 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | The BpeAB-OprB efflux pump of Burkholderia pseudomallei 1026b does not play a role in quorum sensing, virulence factor production, or extrusion of aminoglycosides but is a broad-spectrum drug efflux system. |
| AID1478545 | Acute toxicity in iv dosed mouse at pH 6.6 administered for 4 days | 2017 | Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11 | Covalently linked kanamycin - Ciprofloxacin hybrid antibiotics as a tool to fight bacterial resistance. |
| AID1347680 | Growth inhibition of Yersinia pseudotuberculosis harboring pYV deletion mutant at 50 ug/ml measured at 30 mins interval for 8 hrs | 2017 | Journal of natural products, 12-22, Volume: 80, Issue:12 | Investigation of the Physical and Bioactive Properties of Bromo- and Iodo-Containing Sponge-Derived Compounds Possessing an Oxyphenylethanamine Core. |
| AID425070 | Antimicrobial activity against multidrug-resistant Escherichia coli M7943-TC2 bearing qnrB10 gene with aac(6)-Ib-cr-blaOXA-30 catB3-arr-3 integron in presence of IPTG | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Complex class 1 integrons with diverse variable regions, including aac(6')-Ib-cr, and a novel allele, qnrB10, associated with ISCR1 in clinical enterobacterial isolates from Argentina. |
| AID569255 | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Synthesis and evaluation of anti-tubercular activity of new dithiocarbamate sugar derivatives. |
| AID521601 | Antibacterial activity against Salmonella enterica serovars virchow isolate 101591 infected in mouse J774A.1 macrophage assessed as log reduction in viable counts at 150 ug/ml after 1hr | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Aminoglycosides affect intracellular Salmonella enterica serovars typhimurium and virchow. |
| AID251751 | Antimycobacterial activity of compound against Mycobacterium tuberculosis H37Rv at 5 ug/mL | 2004 | Bioorganic & medicinal chemistry letters, Aug-02, Volume: 14, Issue:15 | Antituberculous activity of some aryl semicarbazone derivatives. |
| AID1164947 | Antimicrobial activity against Pseudomonas aeruginosa PAO1 at >200 ug/ml by microbroth dilution method | 2014 | Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20 | Synthesis, structure-activity relationship studies, and antibacterial evaluation of 4-chromanones and chalcones, as well as olympicin A and derivatives. |
| AID1455934 | Antibacterial activity against Staphylococcus aureus after 48 hrs by broth micro-dilution method | 2017 | Journal of natural products, 02-24, Volume: 80, Issue:2 | Nabscessins A and B, Aminocyclitol Derivatives from Nocardia abscessus IFM 10029 |
| AID584332 | Antibacterial activity against tolC, gshB deficient Escherichia coli GD107 | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12 | Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics. |
| AID1624156 | Antitubercular activity against multidrug-resistant Mycobacterium tuberculosis isolate 8 after 7 days | 2019 | European journal of medicinal chemistry, Feb-15, Volume: 164 | Synthesis and evaluation of α-aminoacyl amides as antitubercular agents effective on drug resistant tuberculosis. |
| AID476722 | Antibacterial activity against Bacillus subtilis ATCC 6633 after 24 hrs by colorimetric method using dye MTT | 2010 | Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7 | Synthesis, molecular modeling and biological evaluation of PSB as targeted antibiotics. |
| AID278237 | Antimicrobial activity against Salmonella enterica serovar Typhimurium S21-2 gyrA+ with ParC S80I mutation | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials. |
| AID1478542 | Antibacterial activity against Escherichia coli ATCC 35218 in 15th subculture in presence of equimolar concentration of ciprofloxacin by double microdilution method | 2017 | Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11 | Covalently linked kanamycin - Ciprofloxacin hybrid antibiotics as a tool to fight bacterial resistance. |
| AID1271385 | Antimicrobial activity against Mycobacterium smegmatis MC2-155 after 16 to 24 hrs by micro-dilution method | 2015 | ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11 | Synthesis and Biological Activity of Mono- and Di-N-acylated Aminoglycosides. |
| AID278271 | Antimicrobial activity against Salmonella enterica serovar Typhimurium CHS38 tolC::Kan with GyrA D87G mutation | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials. |
| AID584831 | Antibacterial activity against Neisseria gonorrhoeae | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Chip calorimetry for fast and reliable evaluation of bactericidal and bacteriostatic treatments of biofilms. |
| AID1562317 | Antimycobacterial activity against Mycobacterium smegmatis atR40 assessed as decrease in drug resistance development at 5 ug/disc after 2 to 3 days by paper disc method | 2019 | European journal of medicinal chemistry, Sep-15, Volume: 178 | Synthesis and antimycobacterial activity of imidazo[1,2-b][1,2,4,5]tetrazines. |
| AID520702 | Antibacterial activity against tetracycline resistant Streptococcus pneumoniae clinical isolate expressing Tn6002 carrying erm(B) and tet(M) gene at 1000 ug by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | erm(B)-carrying elements in tetracycline-resistant pneumococci and correspondence between Tn1545 and Tn6003. |
| AID1617942 | Antibacterial activity against Bacillus subtilis ATCC 6633 after 16 to 48 hrs | 2019 | Journal of natural products, 12-27, Volume: 82, Issue:12 | Structure Determination, Functional Characterization, and Biosynthetic Implications of Nybomycin Metabolites from a Mining Reclamation Site-Associated |
| AID588211 | Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in humans | 2010 | Chemical research in toxicology, Jan, Volume: 23, Issue:1 | Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. |
| AID1565717 | Antibacterial activity against Escherichia coli ATCC 25922 incubated for 18 hrs by two fold dilution method | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Scalable and cost-effective tosylation-mediated synthesis of antifungal and fungal diagnostic 6″-Modified amphiphilic kanamycins. |
| AID683687 | Kinetic solubility of the compound at pH 7.4 | 2012 | European journal of medicinal chemistry, Nov, Volume: 57 | The design, synthesis, in silico ADME profiling, antiplasmodial and antimycobacterial evaluation of new arylamino quinoline derivatives. |
| AID1675235 | Antimicrobial activity against Mycobacterium smegmatis DSM44200 by serial dilution method | 2020 | Journal of natural products, 08-28, Volume: 83, Issue:8 | Heimiomycins A-C and Calamenens from the African Basidiomycete |
| AID424578 | Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH338 (SCV-10) harboring Arg464Cys mutation in fusA gene after 18 to 24 hrs by Etest strip assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID540209 | Volume of distribution at steady state in human after iv administration | 2008 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7 | Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. |
| AID544278 | Antimicrobial activity against Enterococcus faecalis NKH8 harboring pMG2200-like and pMG2201-like plasmids after 24 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Isolation of VanB-type Enterococcus faecalis strains from nosocomial infections: first report of the isolation and identification of the pheromone-responsive plasmids pMG2200, Encoding VanB-type vancomycin resistance and a Bac41-type bacteriocin, and pMG2 |
| AID163066 | ntibacterial activity expressed as MIC value was determined on Proteus rettgeri A-21207 organism | 1986 | Journal of medicinal chemistry, May, Volume: 29, Issue:5 | Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin. |
| AID1418825 | Antibacterial activity against Micrococcus luteus at 1 mg/ml after 48 hrs by agar well diffusion method | 2018 | Bioorganic & medicinal chemistry, 11-15, Volume: 26, Issue:21 | Simplified lipid II-binding antimicrobial peptides: Design, synthesis and antimicrobial activity of bioconjugates of nisin rings A and B with pore-forming peptides. |
| AID490135 | Antibacterial activity against Staphylococcus aureus ATCC 6538 after 24 hrs by MTT assay | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Synthesis of some N-alkyl substituted urea derivatives as antibacterial and antifungal agents. |
| AID164370 | Antibacterial activity expressed as MIC value was determined on Pseudomonas aeruginosa A-21509 organism | 1986 | Journal of medicinal chemistry, May, Volume: 29, Issue:5 | Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin. |
| AID1265800 | Antibacterial activity against Salmonella enterica ATCC 14028 by microdilution method | 2015 | Journal of medicinal chemistry, Dec-10, Volume: 58, Issue:23 | Synthesis and Bioactivities of Kanamycin B-Derived Cationic Amphiphiles. |
| AID619544 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 24 hrs by MTT assay | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10 | Tyrosyl-tRNA synthetase inhibitors as antibacterial agents: synthesis, molecular docking and structure-activity relationship analysis of 3-aryl-4-arylaminofuran-2(5H)-ones. |
| AID1890846 | Selectivity index, ratio of MIC90 for antimycobacterial activity against Mycobacterium smegmatis mc2 155 harbouring pMyC empty vector to MIC90 for antimycobacterial activity against wild type Mycobacterium smegmatis mc2 155 | 2022 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 64 | Design, synthesis and antibacterial activity against pathogenic mycobacteria of conjugated hydroxamic acids, hydrazides and O-alkyl/O-acyl protected hydroxamic derivatives. |
| AID1348087 | Antimicrobial activity against Staphylococcus aureus subsp. aureus ATCC 25923 assessed as zone of inhibition at 50 ug per disc after 24 hrs by disc diffusion assay | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Synthesis of new 1-benzyl tetrahydropyridinylidene ammonium salts and their antimicrobial and anticellular activities. |
| AID477409 | Antibacterial activity against Staphylococcus aureus NCTC 8325 after 16 to 20 hrs by broth microdilution method | 2010 | Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6 | Efflux-mediated bis-indole resistance in Staphylococcus aureus reveals differential substrate specificities for MepA and MepR. |
| AID1402050 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus ATCC 25923 after 18 to 20 hrs by spectrophotometry based microdilution method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Synthesis and antimicrobial activity of amino acid and peptide derivatives of mycophenolic acid. |
| AID563506 | Antimicrobial activity against cetylpyridinium chloride-sensitive Serratia marcescens 71 harboring plasmid STV29 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | Mutational upregulation of a resistance-nodulation-cell division-type multidrug efflux pump, SdeAB, upon exposure to a biocide, cetylpyridinium chloride, and antibiotic resistance in Serratia marcescens. |
| AID534337 | Antimicrobial activity against Burkholderia pseudomallei Bp216 harboring mini-Tn7T after 24 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | The BpeAB-OprB efflux pump of Burkholderia pseudomallei 1026b does not play a role in quorum sensing, virulence factor production, or extrusion of aminoglycosides but is a broad-spectrum drug efflux system. |
| AID283541 | Antibacterial activity against Pseudomonas aeruginosa FE53GU with inactivated mexZ, nuoG and galU genes by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides. |
| AID164372 | Antibacterial activity expressed as MIC value was determined on Pseudomonas aeruginosa A-9834A organism | 1986 | Journal of medicinal chemistry, May, Volume: 29, Issue:5 | Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin. |
| AID544280 | Antimicrobial activity against Enterococcus faecalis NKH10 harboring pMG2200-like and pMG2201-like plasmids after 24 hrs by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Isolation of VanB-type Enterococcus faecalis strains from nosocomial infections: first report of the isolation and identification of the pheromone-responsive plasmids pMG2200, Encoding VanB-type vancomycin resistance and a Bac41-type bacteriocin, and pMG2 |
| AID1565715 | Antifungal activity against Rhodotorula pilimanae ATCC 26423 incubated for 24 to 36 hrs by two fold dilution method | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Scalable and cost-effective tosylation-mediated synthesis of antifungal and fungal diagnostic 6″-Modified amphiphilic kanamycins. |
| AID1477417 | Antibacterial activity against 6-((3-Fluorobenzyl)(methyl)amino)-N-(4-methoxyphenyl)-pyrimidine-4-carboxamide-resisitant Mycobacterium tuberculosis H37Rv grown in GAST/Fe medium measured on day 14 post inoculation by broth microdilution method | 2017 | Journal of medicinal chemistry, 12-28, Volume: 60, Issue:24 | Novel Antitubercular 6-Dialkylaminopyrimidine Carboxamides from Phenotypic Whole-Cell High Throughput Screening of a SoftFocus Library: Structure-Activity Relationship and Target Identification Studies. |
| AID1629131 | Antimicrobial activity against aminoglycoside-resistant Escherichia coli ATCC BAA-2452 measured after 24 hrs by double-dilution method | 2016 | Journal of medicinal chemistry, 09-08, Volume: 59, Issue:17 | Effects of 5-O-Ribosylation of Aminoglycosides on Antimicrobial Activity and Selective Perturbation of Bacterial Translation. |
| AID1402052 | Antibacterial activity against Escherichia coli ATCC 8739 after 18 to 20 hrs by spectrophotometry based microdilution method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Synthesis and antimicrobial activity of amino acid and peptide derivatives of mycophenolic acid. |
| AID278255 | Antimicrobial activity against Salmonella enterica serovar Typhimurium CS3 tolC::Kan with GyrA S83F, D87N, parC S80I mutation | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials. |
| AID1207005 | Antibacterial activity against Staphylococcus epidermidis assessed as growth inhibition at 5 ug/disc after 24 hrs by disc diffusion method | 2015 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 25, Issue:12 | An antibacterial ortho-quinone diterpenoid and its derivatives from Caryopteris mongolica. |
| AID278561 | Antimicrobial activity against 90 mins hydrogen peroxide-stressed Bifidobacterium breve ATCC 15700 after 18 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress. |
| AID625292 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) combined score | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID424830 | Antibacterial activity against kanamycin-resistant and fusidic acid-susceptible Staphylococcus aureus AH417 harboring -1 frameshift mutation at nucleotide 422 in rplF gene after 18 to 24 hrs by Etest strip assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID330982 | Antimicrobial activity against Escherichia coli BAS849 | 2007 | Nature, May-03, Volume: 447, Issue:7140 | PTC124 targets genetic disorders caused by nonsense mutations. |
| AID521593 | Antibacterial activity against Salmonella enterica serovars Typhimurium ATCC 14028 at pH 7.0 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Aminoglycosides affect intracellular Salmonella enterica serovars typhimurium and virchow. |
| AID1594070 | Antibacterial activity against methicillin-resistant Staphylococcus aureus assessed as reduction in bacterial cell viability incubated for 20 to 24 hrs by REMA method | 2019 | Bioorganic & medicinal chemistry, 06-15, Volume: 27, Issue:12 | Design, synthesis, in-silico studies and biological screening of quinazolinone analogues as potential antibacterial agents against MRSA. |
| AID400955 | Antimicrobial activity against Escherichia coli ATCC 25922 by serial broth microdilution method | 2004 | Journal of natural products, Apr, Volume: 67, Issue:4 | Further labdane and kaurane diterpenoids and other constituents from Plectranthus fruticosus. |
| AID1730994 | Antitubercular activity against isoniazid/rifampin/levofloxacin/ofloxacin/kanamycin extensively drug resistance Mycobacterium tuberculosis TF274 XDR by MABA assay | 2021 | European journal of medicinal chemistry, Mar-05, Volume: 213 | Design and synthesis of mycobacterial pks13 inhibitors: Conformationally rigid tetracyclic molecules. |
| AID1695861 | Antibacterial activity against Bacillus cereus ATCC 6630 incubated for 24 hrs | 2019 | European journal of medicinal chemistry, Apr-15, Volume: 168 | Comprehensive review on the anti-bacterial activity of 1,2,3-triazole hybrids. |
| AID424591 | Antibacterial activity against kanamycin-resistant Staphylococcus aureus AH333 (SCV-5) harboring TAA stop codon at nucleotide 249 in rplF but gene after 18 to 24 hrs by Etest strip assay | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. |
| AID283535 | Antibacterial activity against Pseudomonas aeruginosa FE10U with inactivated nuoG and galU genes by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides. |
| AID1478530 | Antibacterial activity against aminoglycosides-resistant Escherichia coli BL21 harboring pET11d encode for APH(3')-2b resistance enzyme by double microdilution method | 2017 | Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11 | Covalently linked kanamycin - Ciprofloxacin hybrid antibiotics as a tool to fight bacterial resistance. |
| AID162906 | Antibacterial activity expressed as MIC value was determined on Proteus rettgeri A-9637 organism | 1986 | Journal of medicinal chemistry, May, Volume: 29, Issue:5 | Aminoglycoside antibiotics. 6. Chemical reactions of aminoglycosides with disodium carbenicillin. |
| AID1657554 | Antimicrobial activity against Shigella dysenteriae incubated for 7 hrs by alamar Blue assay | |||
| AID1765573 | Antibacterial activity against Staphylococcus aureus ATCC 25923 incubated for 18 hrs by CLSI based broth dilution method | 2021 | Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15 | Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice. |
| AID1663465 | Antibacterial activity against Escherichia coli ATCC 8099 incubated for 16 hrs by broth microdilution method | 2020 | Journal of natural products, 06-26, Volume: 83, Issue:6 | Antibacterial Pentacyclic Polyketides from a Soil-Derived |
| AID325445 | Antibacterial activity against Escherichia coli C921-61 after 14 to 16 hrs by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Polyamine effects on antibiotic susceptibility in bacteria. |
| AID1225389 | Antibacterial activity against Escherichia coli transformed with plasmid carrying MG1655 deltaBC/pXYM by p-iodonitrotetrazolium chloride colorimetric assay | 2015 | Journal of natural products, Mar-27, Volume: 78, Issue:3 | Enhancement of antibiotic activity against multidrug-resistant bacteria by the efflux pump inhibitor 3,4-dibromopyrrole-2,5-dione isolated from a Pseudoalteromonas sp. |
| AID1159607 | Screen for inhibitors of RMI FANCM (MM2) intereaction | 2016 | Journal of biomolecular screening, Jul, Volume: 21, Issue:6 | A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 4757 (71.10) | 18.7374 |
| 1990's | 400 (5.98) | 18.2507 |
| 2000's | 505 (7.55) | 29.6817 |
| 2010's | 787 (11.76) | 24.3611 |
| 2020's | 242 (3.62) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.
| This Compound (65.76) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 187 (2.61%) | 5.53% |
| Reviews | 203 (2.83%) | 6.00% |
| Case Studies | 203 (2.83%) | 4.05% |
| Observational | 2 (0.03%) | 0.25% |
| Other | 6,574 (91.70%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||