C-C chemokine receptor type 5

A C-C chemokine receptor type 5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P51681]

Synonyms

C-C CKR-5;
CC-CKR-5;
CCR-5;
CCR5;
CHEMR13;
HIV-1 fusion coreceptor

Research

Bioassay Publications (37)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	15 (40.54)	29.6817
2010's	19 (51.35)	24.3611
2020's	3 (8.11)	2.80

Compounds (23)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
1,10-phenanthroline	Homo sapiens (human)	IC50	51.5593	1	2
2,2'-dipyridyl	Homo sapiens (human)	IC50	81.7164	1	2
disulfiram	Homo sapiens (human)	IC50	23.6610	1	0
disulfiram	Homo sapiens (human)	Ki	18.2840	1	0
terfenadine	Homo sapiens (human)	IC50	1.1030	1	0
terfenadine	Homo sapiens (human)	Ki	0.8520	1	0
4,4'-dimethyl-2,2'-bipyridine	Homo sapiens (human)	IC50	326.6140	1	2
5,5'-dimethyl-2,2'-bipyridyl	Homo sapiens (human)	IC50	202.7630	1	2
neocuproine	Homo sapiens (human)	IC50	30.8114	1	2
2,2',2''-terpyridine	Homo sapiens (human)	IC50	25.0594	1	2
tak 779	Homo sapiens (human)	IC50	0.0024	12	12
maraviroc	Homo sapiens (human)	IC50	0.0044	19	19
vicriviroc	Homo sapiens (human)	IC50	0.0016	3	3
vicriviroc	Homo sapiens (human)	Ki	0.0023	2	2
tak-220	Homo sapiens (human)	IC50	0.0020	2	2
cp 481715	Homo sapiens (human)	Ki	0.0660	1	1
ancriviroc	Homo sapiens (human)	IC50	0.0400	1	1
variecolin	Homo sapiens (human)	IC50	9.0000	1	1
ucb 35625	Homo sapiens (human)	IC50	1.0000	1	1
amd 070	Homo sapiens (human)	IC50	10.0000	1	1
cenicriviroc	Homo sapiens (human)	IC50	0.0030	1	1
19,20-epoxycytochalasin q	Homo sapiens (human)	IC50	60.0000	1	1
fuscin	Homo sapiens (human)	IC50	21.0000	1	1

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
1,10-phenanthroline	Homo sapiens (human)	EC50	4.9559	1	2
2,2'-dipyridyl	Homo sapiens (human)	EC50	19.4763	1	2
4,4'-dimethyl-2,2'-bipyridine	Homo sapiens (human)	EC50	11.7946	1	2
5,5'-dimethyl-2,2'-bipyridyl	Homo sapiens (human)	EC50	2.4059	1	2
neocuproine	Homo sapiens (human)	EC50	65.0478	1	2
2,2',2''-terpyridine	Homo sapiens (human)	EC50	30.3114	1	2
5-methyl-1,10-phenanthroline	Homo sapiens (human)	EC50	1,000.0000	1	2
3,4,7,8-tetramethyl-1,10-phenanthroline	Homo sapiens (human)	EC50	1.0000	1	2
tak 779	Homo sapiens (human)	EC50	0.0070	1	1
aplaviroc	Homo sapiens (human)	Kd	0.0030	1	1
maraviroc	Homo sapiens (human)	EC50	0.0180	1	1
maraviroc	Homo sapiens (human)	Kd	0.0250	1	1

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
maraviroc	Homo sapiens (human)	IC90	0.0100	1	1

Enables

This protein enables 10 target(s):

Target	Category	Definition
virus receptor activity	molecular function	Combining with a virus component and mediating entry of the virus into the cell. [GOC:bf, GOC:dph, PMID:7621403, UniProtKB-KW:KW-1183]
actin binding	molecular function	Binding to monomeric or multimeric forms of actin, including actin filaments. [GOC:clt]
phosphatidylinositol phospholipase C activity	molecular function	Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H+. [EC:3.1.4.11, RHEA:33179]
chemokine receptor activity	molecular function	Combining with a chemokine, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria. [GOC:BHF, GOC:rl, GOC:signaling, IUPHAR_GPCR:1280, PMID:12183377, PMID:8662823, Wikipedia:Chemokine]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
coreceptor activity	molecular function	Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity. [GOC:go_curators]
C-C chemokine receptor activity	molecular function	Combining with a C-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif. [GOC:signaling, PMID:8662823]
C-C chemokine binding	molecular function	Binding to a C-C chemokine; C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif. [GOC:ai]
identical protein binding	molecular function	Binding to an identical protein or proteins. [GOC:jl]
chemokine (C-C motif) ligand 5 binding	molecular function	Binding to chemokine (C-C motif) ligand 5. [GOC:add, GOC:amm]

Located In

This protein is located in 4 target(s):

Target	Category	Definition
endosome	cellular component	A vacuole to which materials ingested by endocytosis are delivered. [ISBN:0198506732, PMID:19696797]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
external side of plasma membrane	cellular component	The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface. [GOC:dos, GOC:tb]
cell surface	cellular component	The external part of the cell wall and/or plasma membrane. [GOC:jl, GOC:mtg_sensu, GOC:sm]

Active In

This protein is active in 3 target(s):

Target	Category	Definition
cell surface	cellular component	The external part of the cell wall and/or plasma membrane. [GOC:jl, GOC:mtg_sensu, GOC:sm]
external side of plasma membrane	cellular component	The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface. [GOC:dos, GOC:tb]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]

Involved In

This protein is involved in 20 target(s):

Target	Category	Definition
MAPK cascade	biological process	An intracellular protein kinase cascade containing at least a MAP kinase (MAPK). It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and a MAPK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell. [PMID:20811974, PMID:9561267]
dendritic cell chemotaxis	biological process	The movement of a dendritic cell in response to an external stimulus. [CL:0000451, GOC:add, ISBN:0781735149, PMID:15814331, PMID:16056255]
calcium ion transport	biological process	The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]
chemotaxis	biological process	The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). [ISBN:0198506732]
cellular defense response	biological process	A defense response that is mediated by cells. [GOC:ebc]
cell surface receptor signaling pathway	biological process	The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription. [GOC:signaling]
G protein-coupled receptor signaling pathway	biological process	The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]
cell-cell signaling	biological process	Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions. [GOC:dos, GOC:mah]
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	biological process	The process in which the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol occurs via calcium release channels. [GOC:mtg_muscle]
calcium-mediated signaling	biological process	Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions. [GOC:signaling]
signaling	biological process	The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered. [GOC:mtg_signal, GOC:mtg_signaling_feb11, GOC:signaling]
symbiont entry into host cell	biological process	The process by which a symbiont breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the symbiont or its genome is released into the host cell. [GOC:jl]
chemokine-mediated signaling pathway	biological process	The series of molecular signals initiated by a chemokine binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mah, GOC:signaling]
response to cholesterol	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholesterol stimulus. [GOC:BHF, GOC:vk]
cellular response to lipopolysaccharide	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria. [GOC:mah]
negative regulation of macrophage apoptotic process	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage apoptotic process. [GOC:BHF, GOC:mtg_apoptosis]
inflammatory response	biological process	The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. [GO_REF:0000022, ISBN:0198506732]
positive regulation of cytosolic calcium ion concentration	biological process	Any process that increases the concentration of calcium ions in the cytosol. [GOC:ai]
immune response	biological process	Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. [GO_REF:0000022, GOC:add]
cell chemotaxis	biological process	The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). [GOC:dph]