A lactoylglutathione lyase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q04760]
EC 4.4.1.5;
Aldoketomutase;
Glyoxalase I;
Glx I;
Ketone-aldehyde mutase;
Methylglyoxalase;
S-D-lactoylglutathione methylglyoxal lyase
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (7.14) | 18.7374 |
| 1990's | 2 (14.29) | 18.2507 |
| 2000's | 1 (7.14) | 29.6817 |
| 2010's | 8 (57.14) | 24.3611 |
| 2020's | 2 (14.29) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| zopolrestat | Homo sapiens (human) | Ki | 0.0012 | 1 | 1 |
| acemetacin | Homo sapiens (human) | Ki | 30.9500 | 2 | 2 |
| fenoprofen | Homo sapiens (human) | Ki | 388.6667 | 3 | 3 |
| indomethacin | Homo sapiens (human) | Ki | 22.1667 | 3 | 3 |
| ketoprofen | Homo sapiens (human) | Ki | 700.0333 | 3 | 3 |
| lapachol | Homo sapiens (human) | Ki | 37.1535 | 1 | 1 |
| tolmetin | Homo sapiens (human) | Ki | 396.5333 | 3 | 3 |
| zomepirac | Homo sapiens (human) | Ki | 259.1000 | 3 | 3 |
| maltol | Homo sapiens (human) | Ki | 223.8720 | 1 | 1 |
| delphinidin | Homo sapiens (human) | IC50 | 1.9000 | 1 | 1 |
| s-(4-bromobenzyl)glutathione | Homo sapiens (human) | IC50 | 19.7600 | 5 | 5 |
| s-(4-bromobenzyl)glutathione | Homo sapiens (human) | Ki | 3.6314 | 5 | 5 |
| s-methyl glutathione | Homo sapiens (human) | Ki | 4,168.6900 | 1 | 1 |
| 8-(methylsulfonylamino)quinoline | Homo sapiens (human) | IC50 | 18.5000 | 1 | 1 |
| 8-(4-benzenesulfonylamino)quinoline | Homo sapiens (human) | IC50 | 8.5000 | 1 | 1 |
| naringenin | Homo sapiens (human) | Ki | 17.3780 | 1 | 1 |
| 3,3',4,5'-tetrahydroxystilbene | Homo sapiens (human) | IC50 | 0.7600 | 1 | 1 |
| ethyl ferulate | Homo sapiens (human) | Ki | 385.0000 | 1 | 1 |
| curcumin | Homo sapiens (human) | Ki | 0.0050 | 1 | 1 |
| sulindac | Homo sapiens (human) | Ki | 108.4500 | 2 | 2 |
| quercetin | Homo sapiens (human) | IC50 | 3.2000 | 1 | 1 |
| quercetin | Homo sapiens (human) | Ki | 15.1356 | 1 | 1 |
| luteolin | Homo sapiens (human) | IC50 | 7.7000 | 1 | 1 |
| kaempferol | Homo sapiens (human) | IC50 | 20.6000 | 1 | 1 |
| baicalein | Homo sapiens (human) | IC50 | 11.0000 | 1 | 1 |
| chrysin | Homo sapiens (human) | Ki | 83.1764 | 1 | 1 |
| fisetin | Homo sapiens (human) | Ki | 13.1826 | 1 | 1 |
| morin | Homo sapiens (human) | Ki | 30.1995 | 1 | 1 |
| myricetin | Homo sapiens (human) | IC50 | 1.5000 | 3 | 3 |
| bisdemethoxycurcumin | Homo sapiens (human) | Ki | 18.1000 | 2 | 2 |
This protein enables 3 target(s):
| Target | Category | Definition |
|---|---|---|
| lactoylglutathione lyase activity | molecular function | Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal. [EC:4.4.1.5, RHEA:19069] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| zinc ion binding | molecular function | Binding to a zinc ion (Zn). [GOC:ai] |
This protein is located in 5 target(s):
| Target | Category | Definition |
|---|---|---|
| nucleoplasm | cellular component | That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653] |
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
This protein is involved in 6 target(s):
| Target | Category | Definition |
|---|---|---|
| carbohydrate metabolic process | biological process | The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. [GOC:mah, ISBN:0198506732] |
| regulation of transcription by RNA polymerase II | biological process | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH] |
| glutathione metabolic process | biological process | The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle. [ISBN:0198506732] |
| methylglyoxal metabolic process | biological process | The chemical reactions and pathways involving methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid. [GOC:ai] |
| osteoclast differentiation | biological process | The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue. [CL:0000092, GOC:add, ISBN:0781735149, PMID:12161749] |
| negative regulation of apoptotic process | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis] |