quinolinic acid has been researched along with Necrosis in 12 studies
Quinolinic Acid: A metabolite of tryptophan with a possible role in neurodegenerative disorders. Elevated CSF levels of quinolinic acid are correlated with the severity of neuropsychological deficits in patients who have AIDS.
pyridinedicarboxylic acid : Any member of the class of pyridines carrying two carboxy groups.
quinolinic acid : A pyridinedicarboxylic acid that is pyridine substituted by carboxy groups at positions 2 and 3. It is a metabolite of tryptophan.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "AIDS-related encephalopathy, including AIDS dementia complex (ADC) and the opportunistic disease, herpes simplex encephalitis (HSE), are postulated to arise due to the release of neurotoxic products, such as quinolinic acid (QUIN), by activated microglial cells in the brain." | 3.73 | Aciclovir protects against quinolinic-acid-induced oxidative neurotoxicity. ( Daya, S; Maharaj, DS; Maharaj, H; Müller, AC, 2005) |
| " Neurotoxic factors produced from activated macrophage or microglial cells such as tumor necrosis factor-alpha (TNFalpha), gp120 and quinolinic acid have been implicated as agents for the cell death which often appears to occur by an apoptotic mechanism." | 3.71 | CPI-1189 attenuates effects of suspected neurotoxins associated with AIDS dementia: a possible role for ERK activation. ( Flitter, WD; Garland, WA; Irwin, I; Kusdra, L; Pulliam, L; Rempel, H, 2001) |
| "Apoptosis and necrosis are generally recognized as two distinct pathways of cell death, based on biochemical and morphological characteristics." | 1.30 | Non-NMDA and NMDA receptor-mediated excitotoxic neuronal deaths in adult brain are morphologically distinct: further evidence for an apoptosis-necrosis continuum. ( Martin, LJ; Portera-Cailliau, C; Price, DL, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (66.67) | 18.2507 |
| 2000's | 4 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Curry, DJ | 1 |
| Wright, DA | 1 |
| Lee, RC | 1 |
| Kang, UJ | 1 |
| Frim, DM | 1 |
| Müller, AC | 1 |
| Maharaj, H | 1 |
| Maharaj, DS | 1 |
| Daya, S | 1 |
| Wolf, G | 1 |
| Würdig, S | 1 |
| Henschke, G | 1 |
| Portera-Cailliau, C | 2 |
| Hedreen, JC | 1 |
| Price, DL | 2 |
| Koliatsos, VE | 1 |
| Wahl, F | 1 |
| Plotkine, M | 1 |
| Boulu, R | 1 |
| Obrenovitch, T | 1 |
| Symon, L | 1 |
| Guarnieri, T | 1 |
| Virgili, M | 1 |
| Carraro, S | 1 |
| Villani, L | 1 |
| Bazzett, TJ | 1 |
| Becker, JB | 1 |
| Kaatz, KW | 1 |
| Albin, RL | 1 |
| Ferrer, I | 1 |
| Martin, F | 1 |
| Serrano, T | 1 |
| Reiriz, J | 1 |
| Pérez-Navarro, E | 1 |
| Alberch, J | 1 |
| Macaya, A | 1 |
| Planas, AM | 1 |
| Martin, LJ | 1 |
| Sei, Y | 1 |
| Fossom, L | 1 |
| Goping, G | 1 |
| Skolnick, P | 1 |
| Basile, AS | 1 |
| St'astný, F | 1 |
| Skultétyová, I | 1 |
| Pliss, L | 1 |
| Jezová, D | 1 |
| Pulliam, L | 1 |
| Irwin, I | 1 |
| Kusdra, L | 1 |
| Rempel, H | 1 |
| Flitter, WD | 1 |
| Garland, WA | 1 |
12 other studies available for quinolinic acid and Necrosis
| Article | Year |
|---|---|
Poloxamer 188 volumetrically decreases neuronal loss in the rat in a time-dependent manner.
Topics: Animals; Apoptosis; Cisterna Magna; Corpus Striatum; Injections, Spinal; Necrosis; Neurons; Poloxame | 2004 |
Aciclovir protects against quinolinic-acid-induced oxidative neurotoxicity.
Topics: Acyclovir; AIDS Dementia Complex; Animals; Antiviral Agents; Brain; Hippocampus; Lipid Peroxidation; | 2005 |
Nitric oxide synthase in the brain: light and electron microscopical findings based on the NADPH-diaphorase reaction.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Oxidoreductases; Animals; Brain | 1994 |
Evidence for apoptotic cell death in Huntington disease and excitotoxic animal models.
Topics: Adult; Aged; Aged, 80 and over; Animals; Apoptosis; Corpus Striatum; Disease Models, Animal; DNA; DN | 1995 |
Involvement of dopaminergic receptors in quinolinate-induced striatal lesions.
Topics: Animals; Corpus Striatum; Dopamine Agents; Dopamine Antagonists; Ergolines; Male; Necrosis; Nerve De | 1993 |
Quinolinic acid but not MK-801 protects the dopaminergic system from 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced toxicity in goldfish retina.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Chromatography, | 1994 |
Chronic intrastriatal dialytic administration of quinolinic acid produces selective neural degeneration.
Topics: Amphetamine; Animals; Atrophy; Corpus Striatum; Dialysis; Dose-Response Relationship, Drug; Electron | 1993 |
Both apoptosis and necrosis occur following intrastriatal administration of excitotoxins.
Topics: Animals; Apoptosis; Cell Death; Corpus Striatum; Immunohistochemistry; Kainic Acid; Male; Necrosis; | 1995 |
Non-NMDA and NMDA receptor-mediated excitotoxic neuronal deaths in adult brain are morphologically distinct: further evidence for an apoptosis-necrosis continuum.
Topics: Animals; Apoptosis; Brain; Cell Death; Dizocilpine Maleate; Kainic Acid; Male; Necrosis; Nerve Degen | 1997 |
Quinolinic acid protects rat cerebellar granule cells from glutamate-induced apoptosis.
Topics: Animals; Apoptosis; Cerebellum; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; G | 1998 |
Quinolinic acid enhances permeability of rat brain microvessels to plasma albumin.
Topics: Animals; Blood-Brain Barrier; Capillary Permeability; Cell Death; Cerebral Ventricles; Hippocampus; | 2000 |
CPI-1189 attenuates effects of suspected neurotoxins associated with AIDS dementia: a possible role for ERK activation.
Topics: AIDS Dementia Complex; Apoptosis; Brain; Butanes; Cells, Cultured; Culture Media, Conditioned; Enzym | 2001 |