methapyrilene has been researched along with Necrosis in 3 studies
Methapyrilene: Histamine H1 antagonist with sedative action used as a hypnotic and in allergies.
methapyrilene : A member of the class of ethylenediamine derivatives that is ethylenediamine in which one of the nitrogens is substituted by two methyl groups, and the other nitrogen is substituted by a 2-pyridyl group and a (2-thienyl)methyl group.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Methapyrilene, [N,N-dimethyl-N'-pyridyl-N'(2-thienylmethyl)-1,2-ethanediamine] (MP) was withdrawn from, clinical use due to reported periportal hepatic necrosis and hepatocarcinogenicity in the rat, via S-oxidation of the thiophene group." | 7.75 | Functional and toxicological consequences of metabolic bioactivation of methapyrilene via thiophene S-oxidation: Induction of cell defence, apoptosis and hepatic necrosis. ( Antoine, DJ; Benson, CA; Foster, J; Graham, EE; Hirst, CM; Kenna, JG; Mercer, AE; Park, BK; Regan, SL; Williams, DP, 2009) |
| "Methapyrilene, [N,N-dimethyl-N'-pyridyl-N'(2-thienylmethyl)-1,2-ethanediamine] (MP) was withdrawn from, clinical use due to reported periportal hepatic necrosis and hepatocarcinogenicity in the rat, via S-oxidation of the thiophene group." | 3.75 | Functional and toxicological consequences of metabolic bioactivation of methapyrilene via thiophene S-oxidation: Induction of cell defence, apoptosis and hepatic necrosis. ( Antoine, DJ; Benson, CA; Foster, J; Graham, EE; Hirst, CM; Kenna, JG; Mercer, AE; Park, BK; Regan, SL; Williams, DP, 2009) |
| "Administration of high doses of the histamine antagonist methapyrilene to rats causes periportal liver necrosis." | 3.73 | Systems toxicology: integrated genomic, proteomic and metabonomic analysis of methapyrilene induced hepatotoxicity in the rat. ( Craig, A; Holmes, E; Jackson, D; Nicholson, J; Nickson, J; Orton, T; Rowlinson, R; Sidaway, J; Tonge, R; Wilson, I, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mercer, AE | 1 |
| Regan, SL | 1 |
| Hirst, CM | 1 |
| Graham, EE | 1 |
| Antoine, DJ | 1 |
| Benson, CA | 1 |
| Williams, DP | 1 |
| Foster, J | 1 |
| Kenna, JG | 1 |
| Park, BK | 1 |
| Craig, A | 1 |
| Sidaway, J | 1 |
| Holmes, E | 1 |
| Orton, T | 1 |
| Jackson, D | 1 |
| Rowlinson, R | 1 |
| Nickson, J | 1 |
| Tonge, R | 1 |
| Wilson, I | 1 |
| Nicholson, J | 1 |
| Graichen, ME | 1 |
| Neptun, DA | 1 |
| Dent, JG | 1 |
| Popp, JA | 1 |
| Leonard, TB | 1 |
3 other studies available for methapyrilene and Necrosis
| Article | Year |
|---|---|
Functional and toxicological consequences of metabolic bioactivation of methapyrilene via thiophene S-oxidation: Induction of cell defence, apoptosis and hepatic necrosis.
Topics: Animals; Apoptosis; Blotting, Western; Cell Survival; Cells, Cultured; Chemical and Drug Induced Liv | 2009 |
Systems toxicology: integrated genomic, proteomic and metabonomic analysis of methapyrilene induced hepatotoxicity in the rat.
Topics: Animals; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Gene Expression R | 2006 |
Effects of methapyrilene on rat hepatic xenobiotic metabolizing enzymes and liver morphology.
Topics: Alanine Transaminase; Aminopyridines; Animals; Bile Acids and Salts; Bile Ducts; Chemical and Drug I | 1985 |