Page last updated: 2024-12-05
trichloronate
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Cross-References
ID Source | ID |
---|---|
PubMed CID | 9477 |
CHEMBL ID | 1875361 |
CHEBI ID | 82150 |
SCHEMBL ID | 117717 |
MeSH ID | M0045422 |
Synonyms (57)
Synonym |
---|
o-ethyl o-2,4,5-trichlorophenyl ethylphosphonothioate |
phosphonothioic acid, ethyl-, o-ethyl o-(2,4,5-trichlorophenyl) ester |
einecs 206-326-1 |
hsdb 1719 |
bayer 37289 |
phytosol |
epa pesticide chemical code 456200 |
bayer s 4400 |
ethyl trichlorophenylethylphosphonothioate |
s 4400 |
5082a |
oms 412 |
trichloronat [bsi:iso] |
oms 578 |
o-aethyl-o-(2,4,5-trichlorphenyl)-aethylthionophosphonat [german] |
stauffer n-3049 |
agrisil |
trichloronate |
phenol, 2,4,5-trichloro-, o-ester with o-ethyl ethylphosphonothioate |
richloronate |
wirkstoff 37289 |
chemagro 37289 |
ent 25,712 |
fenophosphon |
bay 37289 |
bayer 5081 |
fitosol |
caswell no. 456a |
o-ethyl o-(2,4,5-trichlorophenyl) ethylthiophosphonate |
trichloronat |
ai3-25712 |
brn 3373070 |
NCGC00163747-01 |
55228mj5qm , |
o-aethyl-o-(2,4,5-trichlorphenyl)-aethylthionophosphonat |
unii-55228mj5qm |
C19018 |
327-98-0 |
S4400 , |
bayer-s 4400 |
trichloronat [hsdb] |
o-ethyl 0-2,4,5-trichlorophenyl ethylphosphonothioate |
ent-25712 |
trichloronate, (+/-)- |
chemagro-37289 |
(+/-)-trichloronate |
trichloronat [iso] |
bay-37289 |
SCHEMBL117717 |
CHEBI:82150 , |
CHEMBL1875361 |
DTXSID9038420 |
trichloronate 100 microg/ml in cyclohexane |
J-018883 |
o-ethyl o-(2,4,5-trichlorophenyl) ethylphosphonothioate |
Q7840693 |
ethoxy-ethyl-sulfanylidene-(2,4,5-trichlorophenoxy)-lambda5-phosphane |
Research Excerpts
Overview
Trichloronate is a racemic organophosphonothioate insecticide. It induced delayed neuropathic in hens and human.
Excerpt | Reference | Relevance |
---|---|---|
"Trichloronate is a racemic organophosphonothioate insecticide that induced delayed neuropathic in hens and human. " | ( Copper(II)-dependent hydrolysis of trichloronate by turkey serum albumin. Almenares-López, D; Monroy-Noyola, A, 2019) | 2.23 |
Toxicity
Excerpt | Reference | Relevance |
---|---|---|
"The oral LD50 of a compound in hens does not reliably predict the neurotoxic dose of that compound." | ( Consideration of dose levels for delayed neurotoxicity testing in hens: the relationship of neurotoxic dosages to acute LD50 values. Hixson, EJ, 1983) | 0.27 |
" The (-)-trichloronate was 8-11 times more toxic to the test organisms than its (+)-form, while the racemate showed intermediate toxicity." | ( Separation and aquatic toxicity of enantiomers of the organophosphorus insecticide trichloronate. Gan, J; Lin, K; Liu, W, 2006) | 0.98 |
Dosage Studied
Excerpt | Relevance | Reference |
---|---|---|
" The oral LD50 in rats does not predict either the oral LD50 in hens or the neurotoxic dose in hens, so there is no justification for using the rat value to predict the neurotoxic dosage in hens." | ( Consideration of dose levels for delayed neurotoxicity testing in hens: the relationship of neurotoxic dosages to acute LD50 values. Hixson, EJ, 1983) | 0.27 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Drug Classes (1)
Class | Description |
---|---|
organochlorine compound | An organochlorine compound is a compound containing at least one carbon-chlorine bond. |
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Protein Targets (3)
Potency Measurements
Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
---|---|---|---|---|---|---|---|
pregnane X nuclear receptor | Homo sapiens (human) | Potency | 44.6684 | 0.0054 | 28.0263 | 1,258.9301 | AID720659 |
thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 0.0158 | 0.0100 | 39.5371 | 1,122.0200 | AID588545 |
nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 48.5577 | 0.0006 | 27.2152 | 1,122.0200 | AID651741 |
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] |
Research
Studies (10)
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 5 (50.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 2 (20.00) | 29.6817 |
2010's | 1 (10.00) | 24.3611 |
2020's | 2 (20.00) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 21.73
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (21.73) All Compounds (24.57) |
Study Types
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 3 (30.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 7 (70.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |