trichloronate profile

ID Source	ID
PubMed CID	9477
CHEMBL ID	1875361
CHEBI ID	82150
SCHEMBL ID	117717
MeSH ID	M0045422

Synonym
o-ethyl o-2,4,5-trichlorophenyl ethylphosphonothioate
phosphonothioic acid, ethyl-, o-ethyl o-(2,4,5-trichlorophenyl) ester
einecs 206-326-1
hsdb 1719
bayer 37289
phytosol
epa pesticide chemical code 456200
bayer s 4400
ethyl trichlorophenylethylphosphonothioate
s 4400
5082a
oms 412
trichloronat [bsi:iso]
oms 578
o-aethyl-o-(2,4,5-trichlorphenyl)-aethylthionophosphonat [german]
stauffer n-3049
agrisil
trichloronate
phenol, 2,4,5-trichloro-, o-ester with o-ethyl ethylphosphonothioate
richloronate
wirkstoff 37289
chemagro 37289
ent 25,712
fenophosphon
bay 37289
bayer 5081
fitosol
caswell no. 456a
o-ethyl o-(2,4,5-trichlorophenyl) ethylthiophosphonate
trichloronat
ai3-25712
brn 3373070
NCGC00163747-01
55228mj5qm ,
o-aethyl-o-(2,4,5-trichlorphenyl)-aethylthionophosphonat
unii-55228mj5qm
C19018
327-98-0
S4400 ,
bayer-s 4400
trichloronat [hsdb]
o-ethyl 0-2,4,5-trichlorophenyl ethylphosphonothioate
ent-25712
trichloronate, (+/-)-
chemagro-37289
(+/-)-trichloronate
trichloronat [iso]
bay-37289
SCHEMBL117717
CHEBI:82150 ,
CHEMBL1875361
DTXSID9038420
trichloronate 100 microg/ml in cyclohexane
J-018883
o-ethyl o-(2,4,5-trichlorophenyl) ethylphosphonothioate
Q7840693
ethoxy-ethyl-sulfanylidene-(2,4,5-trichlorophenoxy)-lambda5-phosphane

Excerpt	Reference	Relevance
"Trichloronate is a racemic organophosphonothioate insecticide that induced delayed neuropathic in hens and human. "	( Copper(II)-dependent hydrolysis of trichloronate by turkey serum albumin. Almenares-López, D; Monroy-Noyola, A, 2019)	2.23

Excerpt	Reference	Relevance
"The oral LD50 of a compound in hens does not reliably predict the neurotoxic dose of that compound."	( Consideration of dose levels for delayed neurotoxicity testing in hens: the relationship of neurotoxic dosages to acute LD50 values. Hixson, EJ, 1983)	0.27
" The (-)-trichloronate was 8-11 times more toxic to the test organisms than its (+)-form, while the racemate showed intermediate toxicity."	( Separation and aquatic toxicity of enantiomers of the organophosphorus insecticide trichloronate. Gan, J; Lin, K; Liu, W, 2006)	0.98

Excerpt	Relevance	Reference
" The oral LD50 in rats does not predict either the oral LD50 in hens or the neurotoxic dose in hens, so there is no justification for using the rat value to predict the neurotoxic dosage in hens."	( Consideration of dose levels for delayed neurotoxicity testing in hens: the relationship of neurotoxic dosages to acute LD50 values. Hixson, EJ, 1983)	0.27

Class	Description
organochlorine compound	An organochlorine compound is a compound containing at least one carbon-chlorine bond.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
pregnane X nuclear receptor	Homo sapiens (human)	Potency	44.6684	0.0054	28.0263	1,258.9301	AID720659
thyroid hormone receptor beta isoform a	Homo sapiens (human)	Potency	0.0158	0.0100	39.5371	1,122.0200	AID588545
nuclear factor erythroid 2-related factor 2 isoform 1	Homo sapiens (human)	Potency	48.5577	0.0006	27.2152	1,122.0200	AID651741
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	5 (50.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (20.00)	29.6817
2010's	1 (10.00)	24.3611
2020's	2 (20.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	3 (30.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	7 (70.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
chlorpyrifos Chlorpyrifos: An organothiophosphate cholinesterase inhibitor that is used as an insecticide and as an acaricide.. chlorpyrifos : An organic thiophosphate that is O,O-diethyl hydrogen phosphorothioate in which the hydrogen of the hydroxy group has been replaced by a 3,5,6-trichloropyridin-2-yl group.	1.96	1	chloropyridine; organic thiophosphate	acaricide; agrochemical; EC 3.1.1.7 (acetylcholinesterase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor; environmental contaminant; insecticide; xenobiotic
dimethoate Dimethoate: An organothiophosphorus cholinesterase inhibitor that is used as a systemic and contact insecticide.. dimethoate : A monocarboxylic acid amide that is N-methylacetamide in which one of the hydrogens of the methyl group attached to the carbonyl moiety is replaced by a (dimethoxyphosphorothioyl)sulfanediyl group.	2.38	2	monocarboxylic acid amide; organic thiophosphate	acaricide; agrochemical; EC 3.1.1.7 (acetylcholinesterase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor; environmental contaminant; insecticide; xenobiotic
ethoprophos ethoprop: structure	2.01	1	organic thiophosphate; organothiophosphate insecticide	agrochemical; antinematodal drug; EC 3.1.1.7 (acetylcholinesterase) inhibitor
methyl parathion Methyl Parathion: The methyl homolog of parathion. An effective, but highly toxic, organothiophosphate insecticide and cholinesterase inhibitor.. parathion-methyl : A C-nitro compound that is 4-nitrophenol substituted by a (dimethoxyphosphorothioyl)oxy group at position 4.	2.01	1	C-nitro compound; organic thiophosphate; organothiophosphate insecticide	acaricide; agrochemical; antifungal agent; EC 3.1.1.7 (acetylcholinesterase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor; environmental contaminant; genotoxin
phorate Phorate: A cholinesterase inhibitor that is used as an insecticide.. phosphatidylcholine O-34:2 : A glycerophosphocholine that is an alkyl,acyl-sn-glycero-3-phosphocholine in which the alkyl or acyl groups at positions 1 and 2 contain a total of 34 carbons and 2 double bonds.	2.01	1	organic thiophosphate; organothiophosphate insecticide	acaricide; agrochemical; EC 3.1.1.7 (acetylcholinesterase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor
butyl phosphorotrithioate butyl phosphorotrithioate: a herbicide	1.96	1	organic thiophosphate	defoliant
isoflurophate Isoflurophate: A di-isopropyl-fluorophosphate which is an irreversible cholinesterase inhibitor used to investigate the NERVOUS SYSTEM.	1.96	1	dialkyl phosphate
merphos merphos: structure	1.96	1
haloxon haloxon: structure	1.96	1
phenylphosphonothioic acid, 2-ethyl 2-(4-nitrophenyl) ester Phenylphosphonothioic Acid, 2-Ethyl 2-(4-Nitrophenyl) Ester: An organothiophosphorus cholinesterase inhibitor that is used as an insecticide and as a acaricide.	2.36	2	organic phosphonate; organothiophosphate insecticide; phosphonic ester	acaricide; agrochemical; EC 3.1.1.7 (acetylcholinesterase) inhibitor
salithion salithion: causes irreversible ataxia in chicken, mice & sheep; structure in Pesticide Index, 5th ed, p.202	1.96	1	organic thiophosphate
cyanophenphos cyanophenphos: RN given refers to cpd without isomeric designation	1.96	1	benzenes; nitrile
terbufos [no description available]	2.01	1	organic thiophosphate; organosulfur compound; organothiophosphate insecticide	agrochemical; EC 3.1.1.7 (acetylcholinesterase) inhibitor; nematicide
leptophos Leptophos: An organothiophosphate insecticide.. leptophos : A racemate comprising equimolar amounts of (R)- and (S)-leptophos. It is an organothiophosphate insecticide that shows neurotoxic effect in humans.. O-(4-bromo-2,5-dichlorophenyl) O-methyl phenylphosphonothioate : An organic phosphonate that is phenylphosphonothioic O,O-acid in which the hydroxy groups are substituted by methoxy and 4-bromo-2,5-dichlorophenoxy groups.	2.36	2	bromobenzenes; dichlorobenzene; organic phosphonate; phosphonic ester
fenitrothion Fenitrothion: An organothiophosphate cholinesterase inhibitor that is used as an insecticide.. fenitrothion : An organic thiophosphate that is O,O-dimethyl O-phenyl phosphorothioate substituted by a methyl group at position 3 and a nitro group at position 4.	2.01	1	C-nitro compound; organic thiophosphate	acaricide; agrochemical; EC 3.1.1.7 (acetylcholinesterase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor; insecticide
leptophos oxon leptophos oxon: phosvel analog-oxygen substituting sulfur	1.96	1
phosphamidon Phosphamidon: An organophosphate cholinesterase inhibitor that is used as an insecticide.	2.01	1
tetrachlorvinphos Tetrachlorvinphos: An organophosphate cholinesterase inhibitor that is used as an insecticide. It has low mammalian toxicity. (From Merck Index, 11th ed)	2.01	1	alkenyl phosphate; dialkyl phosphate; organochlorine insecticide; organophosphate insecticide; trichlorobenzene	acaricide; agrochemical; EC 3.1.1.7 (acetylcholinesterase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor
cellulose DEAE-Cellulose: Cellulose derivative used in chromatography, as ion-exchange material, and for various industrial applications.	2.03	1	glycoside

Condition	Relationship Strength	Studies
Ataxia Impairment of the ability to perform smoothly coordinated voluntary movements. This condition may affect the limbs, trunk, eyes, pharynx, larynx, and other structures. Ataxia may result from impaired sensory or motor function. Sensory ataxia may result from posterior column injury or PERIPHERAL NERVE DISEASES. Motor ataxia may be associated with CEREBELLAR DISEASES; CEREBRAL CORTEX diseases; THALAMIC DISEASES; BASAL GANGLIA DISEASES; injury to the RED NUCLEUS; and other conditions.	1.96	1
Nerve Degeneration Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.	1.96	1
Polyneuropathy, Acquired [description not available]	1.96	1
Acute Disease Disease having a short and relatively severe course.	1.96	1
Polyneuropathies Diseases of multiple peripheral nerves simultaneously. Polyneuropathies usually are characterized by symmetrical, bilateral distal motor and sensory impairment with a graded increase in severity distally. The pathological processes affecting peripheral nerves include degeneration of the axon, myelin or both. The various forms of polyneuropathy are categorized by the type of nerve affected (e.g., sensory, motor, or autonomic), by the distribution of nerve injury (e.g., distal vs. proximal), by nerve component primarily affected (e.g., demyelinating vs. axonal), by etiology, or by pattern of inheritance.	1.96	1
Brain Disorders [description not available]	1.95	1
Brain Hemorrhage, Cerebral [description not available]	1.95	1
Hematochezia The passage of bright red blood from the rectum. The blood may or may not be mixed with formed stool in the form of blood, blood clots, bloody stool or diarrhea.	1.95	1
Beriberi, Cerebral [description not available]	1.95	1
Brain Diseases Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM.	1.95	1
Cerebral Hemorrhage Bleeding into one or both CEREBRAL HEMISPHERES including the BASAL GANGLIA and the CEREBRAL CORTEX. It is often associated with HYPERTENSION and CRANIOCEREBRAL TRAUMA.	1.95	1
Gastrointestinal Hemorrhage Bleeding in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.	1.95	1
Necrosis The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.	1.95	1
Palsy [description not available]	1.96	1
Peripheral Nerve Diseases [description not available]	1.96	1
Paralysis A general term most often used to describe severe or complete loss of muscle strength due to motor system disease from the level of the cerebral cortex to the muscle fiber. This term may also occasionally refer to a loss of sensory function. (From Adams et al., Principles of Neurology, 6th ed, p45)	1.96	1
Peripheral Nervous System Diseases Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of the nerve roots, ganglia, plexi, autonomic nerves, sensory nerves, and motor nerves.	1.96	1

trichloronate

Cross-References

Synonyms (57)

Research Excerpts

Overview

Toxicity

Dosage Studied

Drug Classes (1)

Protein Targets (3)

Potency Measurements

Research

Studies (10)

Market Indicators

Research Demand Index: 21.73

Study Types

trichloronate

Cross-References

Synonyms (57)

Research Excerpts

Overview

Toxicity

Dosage Studied

Drug Classes (1)

Protein Targets (3)

Potency Measurements

Research

Studies (10)

Market Indicators

Research Demand Index: 21.73

Study Types

Related Drugs (19)

Related Conditions (17)