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D(3) dopamine receptor
A D(3) dopamine receptor that is encoded in the genome of rat. [OMA:P19020, PRO:DNx]
Synonyms
Dopamine D3 receptor
Research
Bioassay Publications (78)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 24 (30.77) | 18.7374 |
| 1990's | 14 (17.95) | 18.2507 |
| 2000's | 24 (30.77) | 29.6817 |
| 2010's | 16 (20.51) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (107)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| 7-hydroxy-2-n,n-dipropylaminotetralin | Rattus norvegicus (Norway rat) | Ki | 0.0040 | 7 | 7 |
| 8-hydroxy-2-(di-n-propylamino)tetralin | Rattus norvegicus (Norway rat) | Ki | 0.2773 | 3 | 3 |
| octoclothepine | Rattus norvegicus (Norway rat) | IC50 | 0.0030 | 1 | 3 |
| theophylline | Rattus norvegicus (Norway rat) | Ki | 0.0006 | 1 | 1 |
| bmy 7378 | Rattus norvegicus (Norway rat) | IC50 | 0.0910 | 1 | 2 |
| bmy 7378 | Rattus norvegicus (Norway rat) | Ki | 0.0031 | 1 | 1 |
| buspirone | Rattus norvegicus (Norway rat) | IC50 | 0.1200 | 1 | 2 |
| chlorpromazine | Rattus norvegicus (Norway rat) | IC50 | 0.0416 | 7 | 12 |
| chlorpromazine | Rattus norvegicus (Norway rat) | Ki | 0.0140 | 1 | 1 |
| clonidine | Rattus norvegicus (Norway rat) | Ki | 4.0000 | 1 | 2 |
| cyproheptadine | Rattus norvegicus (Norway rat) | Ki | 0.0630 | 1 | 1 |
| adtn | Rattus norvegicus (Norway rat) | IC50 | 0.0024 | 2 | 2 |
| fluorescite | Rattus norvegicus (Norway rat) | IC50 | 75.0000 | 1 | 1 |
| granisetron | Rattus norvegicus (Norway rat) | Ki | 0.0091 | 1 | 2 |
| haloperidol | Rattus norvegicus (Norway rat) | IC50 | 0.0067 | 4 | 5 |
| haloperidol | Rattus norvegicus (Norway rat) | Ki | 0.0151 | 10 | 10 |
| imipramine | Rattus norvegicus (Norway rat) | IC50 | 0.8100 | 1 | 1 |
| metoclopramide | Rattus norvegicus (Norway rat) | Ki | 0.2291 | 1 | 2 |
| mianserin | Rattus norvegicus (Norway rat) | Ki | 1.5240 | 1 | 1 |
| nemonapride | Rattus norvegicus (Norway rat) | Ki | 0.0002 | 1 | 1 |
| nomifensine | Rattus norvegicus (Norway rat) | IC50 | 2.7240 | 2 | 2 |
| ondansetron | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 2 | 2 |
| phenoxybenzamine | Rattus norvegicus (Norway rat) | Ki | 0.1200 | 1 | 2 |
| promazine | Rattus norvegicus (Norway rat) | IC50 | 1.0400 | 1 | 2 |
| propranolol | Rattus norvegicus (Norway rat) | Ki | 5.0000 | 1 | 1 |
| quipazine | Rattus norvegicus (Norway rat) | Ki | 0.0010 | 1 | 2 |
| risperidone | Rattus norvegicus (Norway rat) | Ki | 0.0319 | 1 | 1 |
| ropinirole | Rattus norvegicus (Norway rat) | Ki | 0.0293 | 2 | 2 |
| saccharin | Rattus norvegicus (Norway rat) | IC50 | 510.0000 | 1 | 1 |
| spiperone | Rattus norvegicus (Norway rat) | Ki | 0.0020 | 1 | 1 |
| sulpiride | Rattus norvegicus (Norway rat) | Ki | 1.6000 | 1 | 1 |
| suramin | Rattus norvegicus (Norway rat) | IC50 | 18.1000 | 1 | 1 |
| thioridazine | Rattus norvegicus (Norway rat) | IC50 | 0.0850 | 1 | 2 |
| u 99194 | Rattus norvegicus (Norway rat) | Ki | 0.0310 | 1 | 2 |
| wb 4101 | Rattus norvegicus (Norway rat) | Ki | 0.1070 | 1 | 1 |
| apomorphine | Rattus norvegicus (Norway rat) | IC50 | 0.1432 | 7 | 7 |
| alizarin | Rattus norvegicus (Norway rat) | IC50 | 1,160.0000 | 1 | 1 |
| 7-amino-4-hydroxy-2-naphthalenesulfonic acid | Rattus norvegicus (Norway rat) | IC50 | 928.0000 | 1 | 1 |
| 1-naphthol-8-amino-3,6-disulfonic acid | Rattus norvegicus (Norway rat) | IC50 | 540.0000 | 1 | 1 |
| yohimbine | Rattus norvegicus (Norway rat) | Ki | 2.1433 | 2 | 3 |
| apomorphine hydrochloride, anhydrous | Rattus norvegicus (Norway rat) | IC50 | 0.0695 | 1 | 1 |
| apomorphine hydrochloride, anhydrous | Rattus norvegicus (Norway rat) | Ki | 0.0201 | 2 | 2 |
| methyl red | Rattus norvegicus (Norway rat) | IC50 | 440.0000 | 1 | 1 |
| apocodeine | Rattus norvegicus (Norway rat) | IC50 | 6.2000 | 2 | 2 |
| 2-chloro-11-(4-methyl-1-piperazinyl)-5h-dibenzo(b,e)(1,4)diazepine | Rattus norvegicus (Norway rat) | IC50 | 0.7580 | 1 | 1 |
| pimozide | Rattus norvegicus (Norway rat) | IC50 | 0.0004 | 1 | 4 |
| bromocriptine | Rattus norvegicus (Norway rat) | IC50 | 0.0279 | 2 | 3 |
| penfluridol | Rattus norvegicus (Norway rat) | IC50 | 0.0620 | 1 | 2 |
| butaclamol | Rattus norvegicus (Norway rat) | IC50 | 0.0053 | 2 | 3 |
| butaclamol | Rattus norvegicus (Norway rat) | Ki | 0.0039 | 1 | 1 |
| butaclamol | Rattus norvegicus (Norway rat) | IC50 | 0.0020 | 1 | 2 |
| butaclamol | Rattus norvegicus (Norway rat) | Ki | 0.0002 | 1 | 1 |
| acarbose | Rattus norvegicus (Norway rat) | IC50 | 2.0000 | 1 | 1 |
| pergolide | Rattus norvegicus (Norway rat) | IC50 | 0.0031 | 2 | 3 |
| flutroline | Rattus norvegicus (Norway rat) | IC50 | 0.0120 | 1 | 2 |
| quinpirole | Rattus norvegicus (Norway rat) | Ki | 0.0056 | 1 | 1 |
| gepirone | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 2 |
| sertraline hydrochloride | Rattus norvegicus (Norway rat) | IC50 | 0.0700 | 1 | 1 |
| lerisetron | Rattus norvegicus (Norway rat) | Ki | 0.0006 | 1 | 1 |
| sertraline | Rattus norvegicus (Norway rat) | IC50 | 0.2600 | 1 | 2 |
| mezilamine | Rattus norvegicus (Norway rat) | Ki | 0.0400 | 2 | 3 |
| fluorone black | Rattus norvegicus (Norway rat) | IC50 | 126.0000 | 1 | 1 |
| 4-(4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl)-1-(4-fluorophenyl)-1-butanol | Rattus norvegicus (Norway rat) | Ki | 1.0240 | 1 | 1 |
| pramipexole | Rattus norvegicus (Norway rat) | Ki | 0.0006 | 2 | 2 |
| 2-(n,n-dipropyl)amino-5,6-dihydroxytetralin | Rattus norvegicus (Norway rat) | IC50 | 0.1355 | 2 | 3 |
| sonepiprazole | Rattus norvegicus (Norway rat) | Ki | 5.8000 | 1 | 1 |
| 4-hydroxy-2-(di-n-propylamino)indan | Rattus norvegicus (Norway rat) | Ki | 0.0420 | 1 | 2 |
| sk&f-38393 | Rattus norvegicus (Norway rat) | IC50 | 34.4300 | 1 | 1 |
| dexmethylphenidate hydrochloride | Rattus norvegicus (Norway rat) | IC50 | 0.1235 | 2 | 2 |
| chloroethylnorapomorphine | Rattus norvegicus (Norway rat) | IC50 | 5.1970 | 2 | 2 |
| n-n-propylnorapomorphine | Rattus norvegicus (Norway rat) | IC50 | 0.2394 | 2 | 4 |
| 5-hydroxy-2-n,n-dipropylaminotetralin | Rattus norvegicus (Norway rat) | Ki | 0.0016 | 3 | 3 |
| 8-(di-n-propylamino)-6,7,8,9-tetrahydro-3h-benz(e)indole-1-carbaldehyde | Rattus norvegicus (Norway rat) | Ki | 0.0700 | 2 | 2 |
| preclamol | Rattus norvegicus (Norway rat) | IC50 | 0.9300 | 1 | 1 |
| tropisetron | Rattus norvegicus (Norway rat) | Ki | 0.0006 | 1 | 2 |
| n-phenyl-n'-2-pyridylthiourea | Rattus norvegicus (Norway rat) | IC50 | 23.3600 | 1 | 1 |
| 1-(2,5-dimethoxyphenyl)-3-phenylthiourea | Rattus norvegicus (Norway rat) | IC50 | 29.9300 | 1 | 1 |
| 2-(Benzotriazol-1-yl)-1-(4-bromophenyl)ethanone | Rattus norvegicus (Norway rat) | IC50 | 2.7900 | 1 | 1 |
| thiourea | Rattus norvegicus (Norway rat) | IC50 | 21.0000 | 1 | 1 |
| raclopride | Rattus norvegicus (Norway rat) | Ki | 0.0092 | 1 | 1 |
| sch 23390 | Rattus norvegicus (Norway rat) | Ki | 0.7680 | 1 | 1 |
| bp 897 | Rattus norvegicus (Norway rat) | Ki | 0.0202 | 1 | 1 |
| n-(2-(4-(4-chlorophenyl)piperazin-1-yl)ethyl)-3-methoxybenzamide | Rattus norvegicus (Norway rat) | Ki | 1.0000 | 1 | 1 |
| flupenthixol | Rattus norvegicus (Norway rat) | IC50 | 0.0030 | 1 | 3 |
| naloxone | Rattus norvegicus (Norway rat) | Ki | 20.0000 | 1 | 1 |
| sb 277011 | Rattus norvegicus (Norway rat) | Ki | 0.0085 | 2 | 2 |
| l 745870 | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| sb 258719 | Rattus norvegicus (Norway rat) | Ki | 3.9811 | 1 | 1 |
| fluvoxamine | Rattus norvegicus (Norway rat) | IC50 | 0.5400 | 1 | 1 |
| zimeldine | Rattus norvegicus (Norway rat) | IC50 | 4.5000 | 1 | 1 |
| morphine chloride | Rattus norvegicus (Norway rat) | IC50 | 0.0340 | 2 | 4 |
| 8-hydroxy-2-(n-n-propyl-n-(3'-iodo-2'-propenyl)amino)tetralin | Rattus norvegicus (Norway rat) | Ki | 0.1250 | 1 | 1 |
| 7-hydroxy-2-(n-n-propyl-n-(3-iodo-2'-propenyl)-amino)tetralin | Rattus norvegicus (Norway rat) | Ki | 0.0014 | 2 | 2 |
| (8R)-7-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,13,14-triol | Rattus norvegicus (Norway rat) | IC50 | 2.2050 | 2 | 2 |
| (8R)-7-propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,13,14-triol | Rattus norvegicus (Norway rat) | IC50 | 0.3125 | 2 | 2 |
| dihydrexidine | Rattus norvegicus (Norway rat) | Ki | 0.1700 | 1 | 1 |
| l 162313 | Rattus norvegicus (Norway rat) | Ki | 0.0028 | 1 | 1 |
| stepholidine | Rattus norvegicus (Norway rat) | Ki | 0.0300 | 1 | 1 |
| cilansetron | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 2 | 2 |
| vilazodone | Rattus norvegicus (Norway rat) | IC50 | 0.0710 | 1 | 1 |
| n-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)-4-(pyridin-2-yl)benzamide | Rattus norvegicus (Norway rat) | Ki | 0.0006 | 2 | 2 |
| ngb 2904 | Rattus norvegicus (Norway rat) | Ki | 0.0012 | 3 | 4 |
| pnu 96415e | Rattus norvegicus (Norway rat) | Ki | 0.2400 | 1 | 1 |
| fauc 365 | Rattus norvegicus (Norway rat) | Ki | 0.0004 | 2 | 3 |
| 11-hydroxy-n-(n-propyl)noraporphine hydrochloride, (r)-isomer | Rattus norvegicus (Norway rat) | IC50 | 0.3680 | 2 | 2 |
| 11-hydroxy-n-(n-propyl)noraporphine hydrochloride, (r)-isomer | Rattus norvegicus (Norway rat) | Ki | 0.0040 | 1 | 1 |
| 5-hydroxy-2-n,n-dipropylaminotetralin, (s)-isomer | Rattus norvegicus (Norway rat) | Ki | 0.0015 | 4 | 4 |
| octoclothepine, (s)-isomer | Rattus norvegicus (Norway rat) | Ki | 0.0004 | 1 | 1 |
| clozapine | Rattus norvegicus (Norway rat) | IC50 | 0.9312 | 5 | 7 |
| clozapine | Rattus norvegicus (Norway rat) | Ki | 0.3298 | 5 | 5 |
| olanzapine | Rattus norvegicus (Norway rat) | Ki | 0.0390 | 1 | 1 |
| flumezapine | Rattus norvegicus (Norway rat) | IC50 | 0.0200 | 1 | 1 |
Drugs with Activation Measurements
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| spiperone | Rattus norvegicus (Norway rat) | K 0.5 | 0.0004 | 1 | 1 |
| metergoline | Rattus norvegicus (Norway rat) | Activity | 0.0140 | 1 | 1 |
| quinpirole | Rattus norvegicus (Norway rat) | Activity | 10.0000 | 1 | 1 |
| quinpirole | Rattus norvegicus (Norway rat) | K 0.5 | 0.0045 | 1 | 1 |
| quinelorane | Rattus norvegicus (Norway rat) | K 0.5 | 0.0007 | 1 | 1 |
| dihydrexidine | Rattus norvegicus (Norway rat) | K 0.5 | 0.1700 | 1 | 1 |
Further delineation of hydrophobic binding sites in dopamine D(2)/D(3) receptors for N-4 substituents on the piperazine ring of the hybrid template 5/7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro-naphthalen-2-ol.Bioorganic & medicinal chemistry, , Aug-01, Volume: 18, Issue:15, 2010
Investigation of various N-heterocyclic substituted piperazine versions of 5/7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro-naphthalen-2-ol: effect on affinity and selectivity for dopamine D3 receptor.Bioorganic & medicinal chemistry, , Jun-01, Volume: 17, Issue:11, 2009
Structurally constrained hybrid derivatives containing octahydrobenzo[g or f]quinoline moieties for dopamine D2 and D3 receptors: binding characterization at D2/D3 receptors and elucidation of a pharmacophore model.Journal of medicinal chemistry, , Dec-25, Volume: 51, Issue:24, 2008
Bioisosteric heterocyclic versions of 7-{[2-(4-phenyl-piperazin-1-yl)ethyl]propylamino}-5,6,7,8-tetrahydronaphthalen-2-ol: identification of highly potent and selective agonists for dopamine D3 receptor with potent in vivo activity.Journal of medicinal chemistry, , May-22, Volume: 51, Issue:10, 2008
Synthesis of (R,S)-trans-8-hydroxy-2-[N-n-propyl-N-(3'-iodo-2'-propenyl)amino]tetral in (trans-8-OH-PIPAT): a new 5-HT1A receptor ligand.Journal of medicinal chemistry, , Oct-15, Volume: 36, Issue:21, 1993
Synthesis and optical resolution of (R)- and (S)-trans-7-Hydroxy-2-[N-propyl-N-(3'-iodo-2'-propenyl)amino]tetralin: a new D3 dopamine receptor ligand.Journal of medicinal chemistry, , Dec-24, Volume: 36, Issue:26, 1993
Synthesis of (R,S)-2'-trans-7-hydroxy-2-[N-n-propyl-N-(3'-iodo-2'- propenyl)-amino]tetralin (trans-7-OH-PIPAT): a new D3 dopamine receptor ligand.Journal of medicinal chemistry, , May-14, Volume: 36, Issue:10, 1993
Structure-activity relationships in the 8-amino-6,7,8,9-tetrahydro-3H-benz[e]indole ring system. 1. Effects of substituents in the aromatic system on serotonin and dopamine receptor subtypes.Journal of medicinal chemistry, , Jun-09, Volume: 38, Issue:12, 1995
Synthesis of (R,S)-trans-8-hydroxy-2-[N-n-propyl-N-(3'-iodo-2'-propenyl)amino]tetral in (trans-8-OH-PIPAT): a new 5-HT1A receptor ligand.Journal of medicinal chemistry, , Oct-15, Volume: 36, Issue:21, 1993
Synthesis of (R,S)-2'-trans-7-hydroxy-2-[N-n-propyl-N-(3'-iodo-2'- propenyl)-amino]tetralin (trans-7-OH-PIPAT): a new D3 dopamine receptor ligand.Journal of medicinal chemistry, , May-14, Volume: 36, Issue:10, 1993
Synthesis and structure-activity relationship of fluoro analogues of 8-{2-[4-(4-methoxyphenyl)piperazin-1yl]ethyl}-8-azaspiro[4.5]decane-7,9-dione as selective alpha(1d)-adrenergic receptor antagonists.Journal of medicinal chemistry, , Apr-21, Volume: 48, Issue:8, 2005
Buspirone analogues. 1. Structure-activity relationships in a series of N-aryl- and heteroarylpiperazine derivatives.Journal of medicinal chemistry, , Volume: 26, Issue:2, 1983
Azaphenothiazines - promising phenothiazine derivatives. An insight into nomenclature, synthesis, structure elucidation and biological properties.European journal of medicinal chemistry, , Sep-29, Volume: 138, 2017
Neuroleptics from the 4a,9b-trans-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole series. 3. Carboxamidoalkyl derivatives.Journal of medicinal chemistry, , Volume: 29, Issue:10, 1986
Design, synthesis, and X-ray data of novel potential antipsychotic agents. Substituted 7-phenylquinolizidines: stereospecific, neuroleptic, and antinociceptive properties.Journal of medicinal chemistry, , Volume: 27, Issue:2, 1984
Neuroleptic activity and dopamine-uptake inhibition in 1-piperazino-3-phenylindans.Journal of medicinal chemistry, , Volume: 26, Issue:7, 1983
Preparation of some 10-[3-(dimethylamino)-1-propyl]-10H-pyrazino[2,3-b][1,4] benzothiazines as potential neuroleptics.Journal of medicinal chemistry, , Volume: 26, Issue:4, 1983
2-Amino-6-chloro-4-(N-methylpiperazino)pyrimidines, inhibitors of spiroperidol binding.Journal of medicinal chemistry, , Volume: 25, Issue:12, 1982
Conformationally restricted phenothiazine neuroleptics. 1. 3-(Dimethylamino)-1,2,3,4-tetrahydroazepino[3,2,1-kl]phenothiazine.Journal of medicinal chemistry, , Volume: 23, Issue:8, 1980
Antiangiogenic Effect of (±)-Haloperidol Metabolite II Valproate Ester [(±)-MRJF22] in Human Microvascular Retinal Endothelial Cells.Journal of medicinal chemistry, , 11-10, Volume: 59, Issue:21, 2016
Haloperidol metabolite II prodrug: asymmetric synthesis and biological evaluation on rat C6 glioma cells.European journal of medicinal chemistry, , Jan-27, Volume: 90, 2015
Design of novel hexahydropyrazinoquinolines as potent and selective dopamine D3 receptor ligands with improved solubility.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 16, Issue:2, 2006
Pyrrolo[1,3]benzothiazepine-based serotonin and dopamine receptor antagonists. Molecular modeling, further structure-activity relationship studies, and identification of novel atypical antipsychotic agents.Journal of medicinal chemistry, , Jan-01, Volume: 47, Issue:1, 2004
Structure-affinity relationship study on N-[4-(4-arylpiperazin-1-yl)butyl]arylcarboxamides as potent and selective dopamine D(3) receptor ligands.Journal of medicinal chemistry, , Dec-19, Volume: 45, Issue:26, 2002
Synthesis and structure-activity relationships of naphthamides as dopamine D3 receptor ligands.Journal of medicinal chemistry, , May-24, Volume: 44, Issue:11, 2001
Dopamine D3 and D4 receptor antagonists: synthesis and structure--activity relationships of (S)-(+)-N-(1-Benzyl-3-pyrrolidinyl)-5-chloro-4- [(cyclopropylcarbonyl) amino]-2-methoxybenzamide (YM-43611) and related compounds.Journal of medicinal chemistry, , Jul-05, Volume: 39, Issue:14, 1996
A new arylpiperazine antipsychotic with high D2/D3/5-HT1A/alpha 1A-adrenergic affinity and a low potential for extrapyramidal effects.Journal of medicinal chemistry, , Apr-15, Volume: 37, Issue:8, 1994
Synthesis of (R,S)-2'-trans-7-hydroxy-2-[N-n-propyl-N-(3'-iodo-2'- propenyl)-amino]tetralin (trans-7-OH-PIPAT): a new D3 dopamine receptor ligand.Journal of medicinal chemistry, , May-14, Volume: 36, Issue:10, 1993
Neuroleptic activity of chiral trans-hexahydro-gamma-carbolines.Journal of medicinal chemistry, , Volume: 29, Issue:1, 1986
Examination of a series of 8-[3-[bis(4-fluorophenyl)amino]propyl]-1-aryl-1,3,8- triazaspiro[4.5]decan-4-ones as potential antipsychotic agents.Journal of medicinal chemistry, , Volume: 28, Issue:12, 1985
Buspirone analogues. 1. Structure-activity relationships in a series of N-aryl- and heteroarylpiperazine derivatives.Journal of medicinal chemistry, , Volume: 26, Issue:2, 1983
2-Amino-6-chloro-4-(N-methylpiperazino)pyrimidines, inhibitors of spiroperidol binding.Journal of medicinal chemistry, , Volume: 25, Issue:12, 1982
Effects of conformationally restricted 4-piperazinyl-10H-thienobenzodiazepine neuroleptics on central dopaminergic and cholinergic systems.Journal of medicinal chemistry, , Volume: 25, Issue:10, 1982
Modification of agonist binding moiety in hybrid derivative 5/7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro-naphthalen-1-ol/-2-amino versions: impact on functional activity and selectivity for dopamine D2/D3 receptors.Bioorganic & medicinal chemistry, , Jun-01, Volume: 21, Issue:11, 2013
Further delineation of hydrophobic binding sites in dopamine D(2)/D(3) receptors for N-4 substituents on the piperazine ring of the hybrid template 5/7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro-naphthalen-2-ol.Bioorganic & medicinal chemistry, , Aug-01, Volume: 18, Issue:15, 2010
Synthesis and dopaminergic properties of benzo-fused analogues of quinpirole and quinelorane.Journal of medicinal chemistry, , Mar-11, Volume: 42, Issue:5, 1999
Synthesis and receptor binding studies relevant to the neuroleptic activities of some 1-methyl-4-piperidylidene-9-substituted-pyrrolo[2,1-b][3]benzazepine derivatives.Journal of medicinal chemistry, , Volume: 26, Issue:7, 1983
Dopamine autoreceptor agonists as potential antipsychotics. 1. (Aminoalkoxy)anilines.Journal of medicinal chemistry, , Volume: 31, Issue:8, 1988
Dopamine autoreceptor agonists: resolution and pharmacological activity of 2,6-diaminotetrahydrobenzothiazole and an aminothiazole analogue of apomorphine.Journal of medicinal chemistry, , Volume: 30, Issue:3, 1987
Synthesis of 4-substituted 2H-naphth[1,2-b]-1,4-oxazines, a new class of dopamine agonists.Journal of medicinal chemistry, , Volume: 27, Issue:12, 1984
Synthesis and dopaminergic properties of some exo- and endo-2-aminobenzonorbornenes designed as rigid analogue of dopamine.Journal of medicinal chemistry, , Volume: 25, Issue:4, 1982
Aporphines, 36. Dopamine receptor interactions of trihydroxyaporphines. Synthesis, radioreceptor binding, and striatal adenylate cyclase stimulation of 2,10,11-trihydroxyaporphines in comparison with other hydroxylated aporphines.Journal of medicinal chemistry, , Volume: 24, Issue:12, 1981
Synthesis of (R,S)-2'-trans-7-hydroxy-2-[N-n-propyl-N-(3'-iodo-2'- propenyl)-amino]tetralin (trans-7-OH-PIPAT): a new D3 dopamine receptor ligand.Journal of medicinal chemistry, , May-14, Volume: 36, Issue:10, 1993
4-Amino-6-chloro-2-piperazinopyrimidines with selective affinity for alpha 2-adrenoceptors.Journal of medicinal chemistry, , Volume: 29, Issue:8, 1986
Synthesis and neuropharmacological evaluation of 2-aryl- and alkylapomorphines.Bioorganic & medicinal chemistry, , Apr-01, Volume: 16, Issue:7, 2008
Synthesis and structural requirements of N-substituted norapomorphines for affinity and activity at dopamine D-1, D-2, and agonist receptor sites in rat brain.Journal of medicinal chemistry, , Volume: 33, Issue:1, 1990
Synthesis of 4-substituted 2H-naphth[1,2-b]-1,4-oxazines, a new class of dopamine agonists.Journal of medicinal chemistry, , Volume: 27, Issue:12, 1984
Synthesis of (7R)-7H-indolo[3,4-gh][1,4]benzoxazines, a new class of D-heteroergolines with dopamine agonist activity.Journal of medicinal chemistry, , Volume: 26, Issue:3, 1983
Synthesis of (R,S)-2'-trans-7-hydroxy-2-[N-n-propyl-N-(3'-iodo-2'- propenyl)-amino]tetralin (trans-7-OH-PIPAT): a new D3 dopamine receptor ligand.Journal of medicinal chemistry, , May-14, Volume: 36, Issue:10, 1993
Neuroleptics from the 4a,9b-trans-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole series. 3. Carboxamidoalkyl derivatives.Journal of medicinal chemistry, , Volume: 29, Issue:10, 1986
Buspirone analogues. 1. Structure-activity relationships in a series of N-aryl- and heteroarylpiperazine derivatives.Journal of medicinal chemistry, , Volume: 26, Issue:2, 1983
Design, synthesis, and X-ray data of novel potential antipsychotic agents. Substituted 7-phenylquinolizidines: stereospecific, neuroleptic, and antinociceptive properties.Journal of medicinal chemistry, , Volume: 27, Issue:2, 1984
Synthesis and receptor binding studies relevant to the neuroleptic activities of some 1-methyl-4-piperidylidene-9-substituted-pyrrolo[2,1-b][3]benzazepine derivatives.Journal of medicinal chemistry, , Volume: 26, Issue:7, 1983
Synthesis of 4-substituted 2H-naphth[1,2-b]-1,4-oxazines, a new class of dopamine agonists.Journal of medicinal chemistry, , Volume: 27, Issue:12, 1984
Synthesis of (7R)-7H-indolo[3,4-gh][1,4]benzoxazines, a new class of D-heteroergolines with dopamine agonist activity.Journal of medicinal chemistry, , Volume: 26, Issue:3, 1983
Synthesis and pharmacological evaluation of potent and highly selective D3 receptor ligands: inhibition of cocaine-seeking behavior and the role of dopamine D3/D2 receptors.Journal of medicinal chemistry, , Aug-28, Volume: 46, Issue:18, 2003
Synthesis and pharmacological evaluation of thiopyran analogues of the dopamine D3 receptor-selective agonist (4aR,10bR)-(+)-trans-3,4,4a,10b-tetrahydro-4-n-propyl-2H,5H [1]b enzopyrano[4,3-b]-1,4-oxazin-9-ol (PD 128907).Journal of medicinal chemistry, , Jul-27, Volume: 43, Issue:15, 2000
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CJ-1639: A Potent and Highly Selective Dopamine D3 Receptor Full Agonist.ACS medicinal chemistry letters, , Aug-11, Volume: 2, Issue:8, 2011
Design, synthesis, and evaluation of potent and selective ligands for the dopamine 3 (D3) receptor with a novel in vivo behavioral profile.Journal of medicinal chemistry, , Oct-09, Volume: 51, Issue:19, 2008
Thiazoloindans and thiazolobenzopyrans: a novel class of orally active central dopamine (partial) agonists.Journal of medicinal chemistry, , Sep-21, Volume: 43, Issue:19, 2000
[no title available]Bioorganic & medicinal chemistry, , 11-01, Volume: 24, Issue:21, 2016
Further delineation of hydrophobic binding sites in dopamine D(2)/D(3) receptors for N-4 substituents on the piperazine ring of the hybrid template 5/7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro-naphthalen-2-ol.Bioorganic & medicinal chemistry, , Aug-01, Volume: 18, Issue:15, 2010
Investigation of various N-heterocyclic substituted piperazine versions of 5/7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro-naphthalen-2-ol: effect on affinity and selectivity for dopamine D3 receptor.Bioorganic & medicinal chemistry, , Jun-01, Volume: 17, Issue:11, 2009
Structure-activity relationships in the 8-amino-6,7,8,9-tetrahydro-3H-benz[e]indole ring system. 1. Effects of substituents in the aromatic system on serotonin and dopamine receptor subtypes.Journal of medicinal chemistry, , Jun-09, Volume: 38, Issue:12, 1995
Structure-activity relationships in the 8-amino-6,7,8,9-tetrahydro-3H-benz[e]indole ring system. 2. Effects of 8-amino nitrogen substitution on serotonin receptor binding and pharmacology.Journal of medicinal chemistry, , Jun-09, Volume: 38, Issue:12, 1995
Novel morpholine scaffolds as selective dopamine (DA) D3 receptor antagonists.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 26, Issue:4, 2016
Dopamine D3 receptor partial agonists and antagonists as potential drug abuse therapeutic agents.Journal of medicinal chemistry, , Jun-02, Volume: 48, Issue:11, 2005
Synthesis and pharmacological evaluation of thiopyran analogues of the dopamine D3 receptor-selective agonist (4aR,10bR)-(+)-trans-3,4,4a,10b-tetrahydro-4-n-propyl-2H,5H [1]b enzopyrano[4,3-b]-1,4-oxazin-9-ol (PD 128907).Journal of medicinal chemistry, , Jul-27, Volume: 43, Issue:15, 2000
Synthesis and optical resolution of (R)- and (S)-trans-7-Hydroxy-2-[N-propyl-N-(3'-iodo-2'-propenyl)amino]tetralin: a new D3 dopamine receptor ligand.Journal of medicinal chemistry, , Dec-24, Volume: 36, Issue:26, 1993
Synthesis of (R,S)-2'-trans-7-hydroxy-2-[N-n-propyl-N-(3'-iodo-2'- propenyl)-amino]tetralin (trans-7-OH-PIPAT): a new D3 dopamine receptor ligand.Journal of medicinal chemistry, , May-14, Volume: 36, Issue:10, 1993
Dibenzazecine scaffold rebuilding--is the flexibility always essential for high dopamine receptor affinities?Bioorganic & medicinal chemistry, , Oct-01, Volume: 17, Issue:19, 2009
Synthesis and dopaminergic properties of benzo-fused analogues of quinpirole and quinelorane.Journal of medicinal chemistry, , Mar-11, Volume: 42, Issue:5, 1999
Dopamine D3 receptor partial agonists and antagonists as potential drug abuse therapeutic agents.Journal of medicinal chemistry, , Jun-02, Volume: 48, Issue:11, 2005
N-(4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl, butenyl and butynyl)arylcarboxamides as novel dopamine D(3) receptor antagonists.Bioorganic & medicinal chemistry letters, , Jul-07, Volume: 13, Issue:13, 2003
Dopamine D3 receptor partial agonists and antagonists as potential drug abuse therapeutic agents.Journal of medicinal chemistry, , Jun-02, Volume: 48, Issue:11, 2005
Conformationally-flexible benzamide analogues as dopamine D3 and sigma 2 receptor ligands.Bioorganic & medicinal chemistry letters, , Jan-05, Volume: 14, Issue:1, 2004
N-(4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl, butenyl and butynyl)arylcarboxamides as novel dopamine D(3) receptor antagonists.Bioorganic & medicinal chemistry letters, , Jul-07, Volume: 13, Issue:13, 2003
Dopamine D3 receptor partial agonists and antagonists as potential drug abuse therapeutic agents.Journal of medicinal chemistry, , Jun-02, Volume: 48, Issue:11, 2005
Conformationally-flexible benzamide analogues as dopamine D3 and sigma 2 receptor ligands.Bioorganic & medicinal chemistry letters, , Jan-05, Volume: 14, Issue:1, 2004
Synthesis and dopamine agonist and antagonist effects of (R)-(-)- and (S)-(+)-11-hydroxy-N-n-propylnoraporphine.Journal of medicinal chemistry, , Volume: 31, Issue:7, 1988
Aporphines, 36. Dopamine receptor interactions of trihydroxyaporphines. Synthesis, radioreceptor binding, and striatal adenylate cyclase stimulation of 2,10,11-trihydroxyaporphines in comparison with other hydroxylated aporphines.Journal of medicinal chemistry, , Volume: 24, Issue:12, 1981
Development of a Highly Potent D2/D3 Agonist and a Partial Agonist from Structure-Activity Relationship Study of N(6)-(2-(4-(1H-Indol-5-yl)piperazin-1-yl)ethyl)-N(6)-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine Analogues: Implication in the TreatJournal of medicinal chemistry, , Dec-10, Volume: 58, Issue:23, 2015
Modification of agonist binding moiety in hybrid derivative 5/7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro-naphthalen-1-ol/-2-amino versions: impact on functional activity and selectivity for dopamine D2/D3 receptors.Bioorganic & medicinal chemistry, , Jun-01, Volume: 21, Issue:11, 2013
Structure-activity relationship study of N⁶-(2-(4-(1H-Indol-5-yl)piperazin-1-yl)ethyl)-N⁶-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine analogues: development of highly selective D3 dopamine receptor agonists along with a highly potent D2/D3 agoniJournal of medicinal chemistry, , 06-28, Volume: 55, Issue:12, 2012
Novel bivalent ligands for D2/D3 dopamine receptors: Significant co-operative gain in D2 affinity and potency.ACS medicinal chemistry letters, , Oct-26, Volume: 3, Issue:12, 2012
Pyrrolo[1,3]benzothiazepine-based serotonin and dopamine receptor antagonists. Molecular modeling, further structure-activity relationship studies, and identification of novel atypical antipsychotic agents.Journal of medicinal chemistry, , Jan-01, Volume: 47, Issue:1, 2004
Dopamine D3 and D4 receptor antagonists: synthesis and structure--activity relationships of (S)-(+)-N-(1-Benzyl-3-pyrrolidinyl)-5-chloro-4- [(cyclopropylcarbonyl) amino]-2-methoxybenzamide (YM-43611) and related compounds.Journal of medicinal chemistry, , Jul-05, Volume: 39, Issue:14, 1996
(S)-(-)-4-[4-[2-(isochroman-1-yl)ethyl]-piperazin-1-yl] benzenesulfonamide, a selective dopamine D4 antagonist.Journal of medicinal chemistry, , Jun-21, Volume: 39, Issue:13, 1996
A new arylpiperazine antipsychotic with high D2/D3/5-HT1A/alpha 1A-adrenergic affinity and a low potential for extrapyramidal effects.Journal of medicinal chemistry, , Apr-15, Volume: 37, Issue:8, 1994
Examination of a series of 8-[3-[bis(4-fluorophenyl)amino]propyl]-1-aryl-1,3,8- triazaspiro[4.5]decan-4-ones as potential antipsychotic agents.Journal of medicinal chemistry, , Volume: 28, Issue:12, 1985
1-[3-(Diarylamino)propyl]piperidines and related compounds, potential antipsychotic agents with low cataleptogenic profiles.Journal of medicinal chemistry, , Volume: 28, Issue:5, 1985
Buspirone analogues. 1. Structure-activity relationships in a series of N-aryl- and heteroarylpiperazine derivatives.Journal of medicinal chemistry, , Volume: 26, Issue:2, 1983
2-Amino-6-chloro-4-(N-methylpiperazino)pyrimidines, inhibitors of spiroperidol binding.Journal of medicinal chemistry, , Volume: 25, Issue:12, 1982
Effects of conformationally restricted 4-piperazinyl-10H-thienobenzodiazepine neuroleptics on central dopaminergic and cholinergic systems.Journal of medicinal chemistry, , Volume: 25, Issue:10, 1982
Synthesis of clozapine analogues and their affinity for clozapine and spiroperidol binding sites in rat brain.Journal of medicinal chemistry, , Volume: 24, Issue:9, 1981