Page last updated: 2024-08-07 12:59:54
Tissue factor
A tissue factor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P13726]
Synonyms
TF;
Coagulation factor III;
Thromboplastin
Research
Bioassay Publications (11)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 6 (54.55) | 29.6817 |
| 2010's | 4 (36.36) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (39)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| niacinamide | Homo sapiens (human) | Ki | 8,000.0000 | 1 | 1 |
| benzamide | Homo sapiens (human) | Ki | 49,000.0000 | 2 | 2 |
| benzamidine | Homo sapiens (human) | Ki | 240.0000 | 1 | 1 |
| diazoxide | Homo sapiens (human) | IC50 | 740.0000 | 1 | 1 |
| valproic acid | Homo sapiens (human) | IC50 | 1,750.0000 | 2 | 2 |
| entinostat | Homo sapiens (human) | IC50 | 8.0000 | 2 | 2 |
| isocarbostyril | Homo sapiens (human) | Ki | 19,000.0000 | 1 | 1 |
| oleanolic acid | Homo sapiens (human) | IC50 | 0.0050 | 1 | 1 |
| dichlorobenzyl alcohol | Homo sapiens (human) | Ki | 13,000.0000 | 1 | 1 |
| canadine | Homo sapiens (human) | IC50 | 0.0084 | 1 | 1 |
| mifepristone | Homo sapiens (human) | IC50 | 0.0003 | 1 | 1 |
| tetrahydropalmatine | Homo sapiens (human) | IC50 | 0.0228 | 1 | 1 |
| hederagenin | Homo sapiens (human) | IC50 | 0.0002 | 1 | 1 |
| echinocystic acid | Homo sapiens (human) | IC50 | 0.0001 | 1 | 1 |
| 1-aminoisoquinoline | Homo sapiens (human) | Ki | 4,000.0000 | 1 | 1 |
| 5-chloroindole-2-carboxylate | Homo sapiens (human) | Ki | 3,500.0000 | 1 | 1 |
| 5-chloroindole | Homo sapiens (human) | Ki | 4,300.0000 | 1 | 1 |
| corydalmine | Homo sapiens (human) | IC50 | 0.1524 | 1 | 1 |
| trichostatin a | Homo sapiens (human) | IC50 | 0.0320 | 7 | 7 |
| arachidonic acid | Homo sapiens (human) | IC50 | 105.0000 | 1 | 1 |
| palmitoleic acid | Homo sapiens (human) | IC50 | 120.0000 | 1 | 1 |
| oleic acid | Homo sapiens (human) | IC50 | 80.0000 | 1 | 1 |
| eicosapentaenoic acid | Homo sapiens (human) | IC50 | 78.0000 | 1 | 1 |
| curcumin | Homo sapiens (human) | IC50 | 0.0132 | 1 | 1 |
| sodium butyrate | Homo sapiens (human) | IC50 | 1,500.0000 | 2 | 2 |
| linoleic acid | Homo sapiens (human) | IC50 | 41.0000 | 1 | 1 |
| 8,11,14-eicosatrienoic acid | Homo sapiens (human) | IC50 | 52.5000 | 1 | 2 |
| gamma-linolenic acid | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
| alpha-linolenic acid | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
| ginkgolic acid | Homo sapiens (human) | IC50 | 32.0000 | 1 | 1 |
| 11,14,17-eicosatrienoate | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| eicosa-11,14-dienoic acid, (z,z)-isomer | Homo sapiens (human) | IC50 | 52.0000 | 1 | 1 |
| stepholidine | Homo sapiens (human) | IC50 | 0.1046 | 1 | 1 |
| (3S,6S,9S,12R)-3-[(2S)-Butan-2-yl]-6-[(1-methoxyindol-3-yl)methyl]-9-(6-oxooctyl)-1,4,7,10-tetrazabicyclo[10.4.0]hexadecane-2,5,8,11-tetrone | Homo sapiens (human) | IC50 | 0.1750 | 2 | 2 |
| l-873724 | Homo sapiens (human) | IC50 | 0.0002 | 1 | 1 |
| eclalbasaponin i | Homo sapiens (human) | IC50 | 0.0096 | 1 | 1 |
| oleanonic acid | Homo sapiens (human) | IC50 | 0.0002 | 1 | 1 |
| nn 414 | Homo sapiens (human) | IC50 | 696.0000 | 1 | 1 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| geldanamycin | Homo sapiens (human) | Concentration | 5.0000 | 1 | 1 |
Discovery of Phenylglycine Lactams as Potent Neutral Factor VIIa Inhibitors.ACS medicinal chemistry letters, , Dec-08, Volume: 7, Issue:12, 2016
Discovery of novel P1 groups for coagulation factor VIIa inhibition using fragment-based screening.Journal of medicinal chemistry, , Mar-26, Volume: 58, Issue:6, 2015
Histone deacetylase inhibitors suppress TF-kappaB-dependent agonist-driven tissue factor expression in endothelial cells and monocytes.The Journal of biological chemistry, , Sep-28, Volume: 282, Issue:39, 2007
Highly potent and selective histone deacetylase 6 inhibitors designed based on a small-molecular substrate.Journal of medicinal chemistry, , Aug-10, Volume: 49, Issue:16, 2006
Enables
This protein enables 4 target(s):
| Target | Category | Definition |
|---|
| protease binding | molecular function | Binding to a protease or a peptidase. [GOC:hjd] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| phospholipid binding | molecular function | Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester. [ISBN:0198506732] |
| cytokine receptor activity | molecular function | Combining with a cytokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:add, GOC:mah] |
Located In
This protein is located in 6 target(s):
| Target | Category | Definition |
|---|
| extracellular space | cellular component | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684] |
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| external side of plasma membrane | cellular component | The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface. [GOC:dos, GOC:tb] |
| cell surface | cellular component | The external part of the cell wall and/or plasma membrane. [GOC:jl, GOC:mtg_sensu, GOC:sm] |
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
| collagen-containing extracellular matrix | cellular component | An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells. [GOC:BHF, GOC:rph, PMID:21123617] |
Active In
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
Part Of
This protein is part of 1 target(s):
| Target | Category | Definition |
|---|
| serine-type peptidase complex | cellular component | A protein complex which is capable of serine-type peptidase activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:18640965] |
Involved In
This protein is involved in 12 target(s):
| Target | Category | Definition |
|---|
| positive regulation of endothelial cell proliferation | biological process | Any process that activates or increases the rate or extent of endothelial cell proliferation. [GOC:add] |
| activation of plasma proteins involved in acute inflammatory response | biological process | Any process activating plasma proteins by proteolysis as part of an acute inflammatory response. [GOC:jal, ISBN:0781735149] |
| activation of blood coagulation via clotting cascade | biological process | Any process that initiates the clotting cascade of blood coagulation, a cascade of plasma enzymes that is triggered following damage to blood vessels, leading to formation of a clot. [GOC:jal, ISBN:0781735149] |
| activation of cysteine-type endopeptidase activity involved in apoptotic process | biological process | Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process. [GOC:al, GOC:dph, GOC:jl, GOC:mtg_apoptosis, GOC:tb, PMID:14744432, PMID:18328827, Wikipedia:Caspase] |
| blood coagulation | biological process | The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers. [PMID:30700128] |
| positive regulation of platelet-derived growth factor receptor signaling pathway | biological process | Any process that increases the frequency, rate or extent of the platelet-derived growth factor receptor signaling pathway. [GOC:dph, GOC:hjd, GOC:tb] |
| protein processing | biological process | Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein. [GOC:curators, GOC:jl, GOC:jsg] |
| positive regulation of cell migration | biological process | Any process that activates or increases the frequency, rate or extent of cell migration. [GOC:go_curators] |
| positive regulation of TOR signaling | biological process | Any process that activates or increases the frequency, rate or extent of TOR signaling. [GOC:mah] |
| positive regulation of angiogenesis | biological process | Any process that activates or increases angiogenesis. [GOC:go_curators] |
| positive regulation of positive chemotaxis | biological process | Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical. [GOC:ai] |
| cytokine-mediated signaling pathway | biological process | The series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mah, GOC:signaling, PMID:19295629] |