Page last updated: 2024-08-07 16:14:31
Adenosylhomocysteinase
An adenosylhomocysteinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P23526]
Synonyms
AdoHcyase;
EC 3.3.1.1;
S-adenosyl-L-homocysteine hydrolase
Research
Bioassay Publications (22)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 4 (18.18) | 18.7374 |
| 1990's | 4 (18.18) | 18.2507 |
| 2000's | 8 (36.36) | 29.6817 |
| 2010's | 4 (18.18) | 24.3611 |
| 2020's | 2 (9.09) | 2.80 |
Compounds (17)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| 3-deazaadenosine | Homo sapiens (human) | IC50 | 4.6950 | 2 | 2 |
| aristeromycin | Homo sapiens (human) | IC50 | 2.1577 | 3 | 3 |
| aristeromycin | Homo sapiens (human) | Ki | 0.1100 | 1 | 1 |
| illimaquinone | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| 3-deazaaristeromycin | Homo sapiens (human) | Ki | 0.0040 | 1 | 1 |
| neplanocin a | Homo sapiens (human) | IC50 | 0.5236 | 6 | 6 |
| neplanocin a | Homo sapiens (human) | Ki | 0.0038 | 3 | 3 |
| 3-deazaneplanocin | Homo sapiens (human) | IC50 | 0.4400 | 1 | 1 |
| 3-deazaneplanocin | Homo sapiens (human) | Ki | 0.0000 | 1 | 1 |
| 9-(2',3'-dihydroxycyclopentan-1'-yl)adenine | Homo sapiens (human) | IC50 | 6.0188 | 3 | 3 |
| 9-(2',3'-dihydroxycyclopentan-1'-yl)adenine | Homo sapiens (human) | Ki | 0.0120 | 1 | 1 |
| adenosine-5'-carboxylic acid | Homo sapiens (human) | Ki | 0.4100 | 1 | 1 |
| 5'-n-methylcarboxamideadenosine | Homo sapiens (human) | Ki | 1.9300 | 1 | 1 |
| 5'-noraristeromycin | Homo sapiens (human) | IC50 | 1.7667 | 3 | 3 |
| 5'-noraristeromycin | Homo sapiens (human) | Ki | 0.1600 | 1 | 1 |
| adenosine-5'-carboxaldehyde | Homo sapiens (human) | Ki | 0.0403 | 3 | 3 |
| 9-(2',3'-dihydroxycyclopent-4'-enyl)adenine | Homo sapiens (human) | IC50 | 4.8830 | 4 | 4 |
| 9-(2',3'-dihydroxycyclopent-4'-enyl)adenine | Homo sapiens (human) | Ki | 0.0450 | 2 | 2 |
| 5'-amino-5'-deoxyadenosine | Homo sapiens (human) | IC50 | 75.0200 | 1 | 1 |
| guanosine | Homo sapiens (human) | Ki | 1,472.0000 | 1 | 1 |
| inosine | Homo sapiens (human) | Ki | 925.0000 | 1 | 1 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| ribavirin | Homo sapiens (human) | Kinact | 266.0000 | 1 | 1 |
| ribavirin | Homo sapiens (human) | KR | 407.0000 | 1 | 1 |
| adenosine | Homo sapiens (human) | Km | 0.8200 | 1 | 1 |
| guanosine | Homo sapiens (human) | Km | 844.0000 | 1 | 1 |
| inosine | Homo sapiens (human) | Km | 2.5000 | 1 | 1 |
Enables
This protein enables 2 target(s):
| Target | Category | Definition |
|---|---|---|
| adenosylhomocysteinase activity | molecular function | Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine. [RHEA:21708] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
Located In
This protein is located in 5 target(s):
| Target | Category | Definition |
|---|---|---|
| nucleus | cellular component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
| endoplasmic reticulum | cellular component | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| melanosome | cellular component | A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells. [GOC:jl, PMID:11584301] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
Active In
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
Involved In
This protein is involved in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| one-carbon metabolic process | biological process | The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. [GOC:hjd, GOC:mah, GOC:pde] |
| S-adenosylmethionine cycle | biological process | A cyclic series of interconversions involving S-adenosylmethionine, S-adenosyl-L-homocysteine, L-cysteine, and L-methionine. Couples utilization of the methyl group of SAM with recycling of the homocysteinyl group and regeneration of methionine. [GOC:mah, MetaCyc:PWY-5041] |