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Adenosylhomocysteinase
An adenosylhomocysteinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P23526]
Synonyms
AdoHcyase;
EC 3.3.1.1;
S-adenosyl-L-homocysteine hydrolase
Research
Bioassay Publications (22)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 4 (18.18) | 18.7374 |
| 1990's | 4 (18.18) | 18.2507 |
| 2000's | 8 (36.36) | 29.6817 |
| 2010's | 4 (18.18) | 24.3611 |
| 2020's | 2 (9.09) | 2.80 |
Compounds (17)
Drugs with Inhibition Measurements
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| ribavirin | Homo sapiens (human) | Kinact | 266.0000 | 1 | 1 |
| ribavirin | Homo sapiens (human) | KR | 407.0000 | 1 | 1 |
| adenosine | Homo sapiens (human) | Km | 0.8200 | 1 | 1 |
| guanosine | Homo sapiens (human) | Km | 844.0000 | 1 | 1 |
| inosine | Homo sapiens (human) | Km | 2.5000 | 1 | 1 |
[no title available]Journal of medicinal chemistry, , 07-11, Volume: 62, Issue:13, 2019
Adenosine analogue inhibitors of S-adenosylhomocysteine hydrolase.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 24, Issue:12, 2014
Synthesis of 2-modified aristeromycins and their analogs as potent inhibitors against Plasmodium falciparum S-adenosyl-L-homocysteine hydrolase.Bioorganic & medicinal chemistry, , Apr-01, Volume: 16, Issue:7, 2008
Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 9. 2',3'-Dialdehyde derivatives of carbocyclic purine nucleosides as inhibitors of S-adenosylhomocysteine hydrolase.Journal of medicinal chemistry, , Volume: 28, Issue:4, 1985
Structure-Activity Relationships of Neplanocin A Analogues as S-Adenosylhomocysteine Hydrolase Inhibitors and Their Antiviral and Antitumor Activities.Journal of medicinal chemistry, , Jun-25, Volume: 58, Issue:12, 2015
Adenosine analogue inhibitors of S-adenosylhomocysteine hydrolase.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 24, Issue:12, 2014
X-ray crystal structure and binding mode analysis of human S-adenosylhomocysteine hydrolase complexed with novel mechanism-based inhibitors, haloneplanocin A analogues.Journal of medicinal chemistry, , Feb-24, Volume: 54, Issue:4, 2011
A new structural class of S-adenosylhomocysteine hydrolase inhibitors.Bioorganic & medicinal chemistry, , Sep-15, Volume: 17, Issue:18, 2009
Synthesis of fluorinated cyclopentenyladenine as potent inhibitor of S-adenosylhomocysteine hydrolase.Bioorganic & medicinal chemistry letters, , May-03, Volume: 14, Issue:9, 2004
4'-modified analogues of aristeromycin and neplanocin A: synthesis and inhibitory activity toward S-adenosyl-L-homocysteine hydrolase.Journal of medicinal chemistry, , May-15, Volume: 35, Issue:10, 1992
9-(trans-2',trans-3'-dihydroxycyclopent-4'-enyl) derivatives of adenine and 3-deazaadenine: potent inhibitors of bovine liver S-adenosylhomocysteine hydrolase.Journal of medicinal chemistry, , Volume: 31, Issue:3, 1988
Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 11. Molecular dissections of neplanocin A as potential inhibitors of S-adenosylhomocysteine hydrolase.Journal of medicinal chemistry, , Volume: 31, Issue:9, 1988
Targeting Enhancer of Zeste Homolog 2 for the Treatment of Hematological Malignancies and Solid Tumors: Candidate Structure-Activity Relationships Insights and Evolution Prospects.Journal of medicinal chemistry, , 05-26, Volume: 65, Issue:10, 2022
Structure-Activity Relationships of Neplanocin A Analogues as S-Adenosylhomocysteine Hydrolase Inhibitors and Their Antiviral and Antitumor Activities.Journal of medicinal chemistry, , Jun-25, Volume: 58, Issue:12, 2015
Adenosine analogue inhibitors of S-adenosylhomocysteine hydrolase.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 24, Issue:12, 2014
Synthesis of 4'-modified noraristeromycins to clarify the effect of the 4'-hydroxyl groups for inhibitory activity against S-adenosyl-L-homocysteine hydrolase.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
4'-modified analogues of aristeromycin and neplanocin A: synthesis and inhibitory activity toward S-adenosyl-L-homocysteine hydrolase.Journal of medicinal chemistry, , May-15, Volume: 35, Issue:10, 1992
Synthesis of 4'-modified noraristeromycins to clarify the effect of the 4'-hydroxyl groups for inhibitory activity against S-adenosyl-L-homocysteine hydrolase.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Synthesis of 2-modified aristeromycins and their analogs as potent inhibitors against Plasmodium falciparum S-adenosyl-L-homocysteine hydrolase.Bioorganic & medicinal chemistry, , Apr-01, Volume: 16, Issue:7, 2008
Synthesis of 2-fluoronoraristeromycin and its inhibitory activity against Plasmodium falciparum S-adenosyl-L-homocysteine hydrolase.Bioorganic & medicinal chemistry letters, , Nov-17, Volume: 13, Issue:22, 2003
Anticancer and antiviral effects and inactivation of S-adenosyl-L-homocysteine hydrolase with 5'-carboxaldehydes and oximes synthesized from adenosine and sugar-modified analogues.Journal of medicinal chemistry, , May-23, Volume: 40, Issue:11, 1997
Inactivation of S-adenosyl-L-homocysteine hydrolase by amide and ester derivatives of adenosine-5'-carboxylic acid.Journal of medicinal chemistry, , Oct-11, Volume: 39, Issue:21, 1996
Aristeromycin-5'-carboxaldehyde: a potent inhibitor of S-adenosyl-L-homocysteine hydrolase.Journal of medicinal chemistry, , Jun-07, Volume: 39, Issue:12, 1996
Adenosine analogue inhibitors of S-adenosylhomocysteine hydrolase.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 24, Issue:12, 2014
X-ray crystal structure and binding mode analysis of human S-adenosylhomocysteine hydrolase complexed with novel mechanism-based inhibitors, haloneplanocin A analogues.Journal of medicinal chemistry, , Feb-24, Volume: 54, Issue:4, 2011
Synthesis of fluorinated cyclopentenyladenine as potent inhibitor of S-adenosylhomocysteine hydrolase.Bioorganic & medicinal chemistry letters, , May-03, Volume: 14, Issue:9, 2004
4'-modified analogues of aristeromycin and neplanocin A: synthesis and inhibitory activity toward S-adenosyl-L-homocysteine hydrolase.Journal of medicinal chemistry, , May-15, Volume: 35, Issue:10, 1992
9-(trans-2',trans-3'-dihydroxycyclopent-4'-enyl) derivatives of adenine and 3-deazaadenine: potent inhibitors of bovine liver S-adenosylhomocysteine hydrolase.Journal of medicinal chemistry, , Volume: 31, Issue:3, 1988
Enables
This protein enables 2 target(s):
| Target | Category | Definition |
|---|
| adenosylhomocysteinase activity | molecular function | Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine. [RHEA:21708] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
Located In
This protein is located in 5 target(s):
| Target | Category | Definition |
|---|
| nucleus | cellular component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
| endoplasmic reticulum | cellular component | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| melanosome | cellular component | A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells. [GOC:jl, PMID:11584301] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
Active In
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
Involved In
This protein is involved in 2 target(s):
| Target | Category | Definition |
|---|
| one-carbon metabolic process | biological process | The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. [GOC:hjd, GOC:mah, GOC:pde] |
| S-adenosylmethionine cycle | biological process | A cyclic series of interconversions involving S-adenosylmethionine, S-adenosyl-L-homocysteine, L-cysteine, and L-methionine. Couples utilization of the methyl group of SAM with recycling of the homocysteinyl group and regeneration of methionine. [GOC:mah, MetaCyc:PWY-5041] |