| ID Source | ID |
|---|---|
| PubMed CID | 40634 |
| CHEMBL ID | 153 |
| CHEBI ID | 82625 |
| SCHEMBL ID | 3226 |
| MeSH ID | M0056270 |
| Synonym |
|---|
| OPREA1_727377 |
| smr001233218 |
| MLS002153860 |
| BRD-A17846016-001-03-0 |
| einecs 258-422-8 |
| trolox c |
| 6-hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid |
| 3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2h-1-benzopyran-2-carboxylic acid |
| 2h-1-benzopyran-2-carboxylic acid, 3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-, (+-)- |
| brn 5052542 |
| PRESTWICK_855 |
| NCGC00179534-01 |
| PRESTWICK2_000530 |
| PRESTWICK3_000530 |
| BSPBIO_000519 |
| 2h-1-benzopyran-2-carboxylic acid, 3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl- |
| 53188-07-1 |
| trolox , |
| 6-hydroxy-2,5,7,8-tetramethyl-chromane-2-carboxylic acid |
| (+/-)-6-hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid, 97% |
| 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid |
| PRESTWICK1_000530 |
| PRESTWICK0_000530 |
| SPBIO_002440 |
| BPBIO1_000571 |
| 3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2h-1-benzopyran-2- carboxylic acid |
| 56305-04-5 |
| (r,s)-6-hydroxy-2,5,7,8-tetramethyl-2-chromanecarboxylic acid |
| 6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2h-chromene-2-carboxylic acid |
| chebi:82625 , |
| CHEMBL153 |
| 6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydrochromene-2-carboxylic acid |
| H0726 |
| HMS1569J21 |
| HMS2096J21 |
| HMS2230A15 |
| S3665 |
| s18ul9710x , |
| unii-s18ul9710x |
| bdbm50359629 |
| FT-0621156 |
| AKOS015856256 |
| 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid, (+/-)- |
| (+/-)-6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid |
| (+/-)-trolox |
| trolox [inci] |
| trolox [mi] |
| 2h-1-benzopyran-2-carboxylic acid, 3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-, (+/-)- |
| HMS3369E20 |
| CCG-207912 |
| SCHEMBL3226 |
| 6-hydroxy-3,4-dihydro-2,5,7,8-tetramethyl-2h-1-benzopyran-2-carboxylic acid |
| 6-hydroxy-2,5,7,8-tetramethyl-chroman-2-carboxylic acid |
| (6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)carboxylic acid |
| 6-hydroxy-2,5,7,8-tetramethychroman-2-carboxylic acid |
| (+/-)- 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid |
| 6-hydroxy-2,5,7,8-tetramethyl-2-chromanecarboxylic acid # |
| HY-101445 |
| CS-8035 |
| GEO-03688 |
| (+/-)-6-hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid |
| mfcd00006846 |
| 6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2h-1-benzopyran-2-carboxylic acid |
| SR-01000841227-2 |
| sr-01000841227 |
| trolox(tm) |
| 6-hydroxy-2,5,7,8-tetramethyl-2-chromancarboxylic acid |
| HMS3713J21 |
| BBL103047 |
| STL556856 |
| FT-0770514 |
| BCP16474 |
| DTXSID60866306 |
| 3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2h-1-benzopyran-2-carboxylic acid; |
| (s)-(-)-6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylicacid |
| Q245489 |
| AS-30121 |
| BRD-A17846016-001-07-1 |
| HMS3885K19 |
| trolox is also know as 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid. |
| EN300-370592 |
| Z3013814504 |
| Excerpt | Reference | Relevance |
|---|---|---|
| " In isolated perfused livers from fasted rats, sodium orthovanadate (2 mmol/l) led to toxic responses including reduction of oxygen consumption, release of cytosolic (glutamate-pyruvate-transaminase (GPT) and lactate dehydrogenase (LDH)) and mitochondrial (glutamate-dehydrogenase (GLDH)) enzymes, intracellular accumulation of calcium, a marked depletion of glutathione (GSH) and an enhanced formation and release of thiobarbituric acid- (TBA) reactive material." | ( Effect of antioxidants on vanadate-induced toxicity towards isolated perfused rat livers. Kayser, E; Strubelt, O; Younes, M, 1991) | 0.28 |
| " In contrast to arachidonic acid, oleic acid was not toxic to the Hep G2-MV2E1-9 cells." | ( Cytotoxicity and apoptosis produced by arachidonic acid in Hep G2 cells overexpressing human cytochrome P4502E1. Cederbaum, AI; Chen, Q; Galleano, M, 1997) | 0.3 |
| "Ethanol and polyunsaturated fatty acids such as arachidonic acid were shown to be toxic and cause apoptosis in HepG2 cells which express CYP2E1 but not in control HepG2 cell lines." | ( Ethanol and arachidonic acid produce toxicity in hepatocytes from pyrazole-treated rats with high levels of CYP2E1. Cederbaum, AI; Wu, D, 2000) | 0.31 |
| " It is primarily considered as a neurotoxin but its other toxic manifestations are also well documented." | ( Pharmacological interventions of cyanide-induced cytotoxicity and DNA damage in isolated rat thymocytes and their protective efficacy in vivo. Bhattacharya, R; Lakshmana Rao, PV, 2001) | 0.31 |
| " The specific metal responsible for the toxicity was not determined; the metals common to each of the toxic archwires were nickel, iron, and chromium." | ( In vitro cytotoxicity of orthodontic archwires in cortical cell cultures. David, A; Lobner, D, 2004) | 0.32 |
| " Tat is neurotoxic and a constantly growing body of evidence suggests that the toxic effects of Tat are oxidative stress-dependent." | ( Cocaine-mediated enhancement of Tat toxicity in rat hippocampal cell cultures: the role of oxidative stress and D1 dopamine receptor. Aksenov, MY; Aksenova, MV; Booze, RM; Mactutus, CF; Nath, A; Ray, PD, 2006) | 0.33 |
| "The ability of the water-soluble Vitamin E analog, Trolox, to prevent the toxic effects of copper exposure on the behavior and neuronal physiology of the freshwater oligochaete Lumbriculus variegatus was examined." | ( The Vitamin E analog Trolox reduces copper toxicity in the annelid Lumbriculus variegatus but is also toxic on its own. Hoyt, EM; Leigh-Logan, T; Murray, PM; O'Gara, BA; Smeaton, MB, 2006) | 0.33 |
| " In addition, a short-term toxicity assessment in rats was also conducted for the identification of certain toxic effects of AG after heat processing." | ( Increase in the free radical scavenging activities of American ginseng by heat processing and its safety evaluation. Kang, KS; Kim, HY; Okamoto, T; Sei, Y; Yamabe, N; Yokozawa, T, 2007) | 0.34 |
| "Amiodarone (AM), a drug used in the treatment of cardiac dysrrhythmias, can produce severe pulmonary adverse effects, including fibrosis." | ( Direct mitochondrial dysfunction precedes reactive oxygen species production in amiodarone-induced toxicity in human peripheral lung epithelial HPL1A cells. Brien, JF; Comeau, JL; Hill, BC; Ji, Y; Massey, TE; Nicolescu, AC; Racz, WJ; Takahashi, T, 2008) | 0.35 |
| " The aim of this study was to address the toxic effects of MnCl2 and MnSO4 on the immortalized rat brain microvessel endothelial cell line (RBE4) and to characterize toxic mechanism associated with exposure to Mn." | ( Antioxidants prevent the cytotoxicity of manganese in RBE4 cells. Aschner, M; Au, C; Batoréu, MC; Marreilha dos Santos, AP; Milatovic, D; Santos, D, 2008) | 0.35 |
| " possible adverse neurological damage caused by MeHg." | ( The in vitro effects of Trolox on methylmercury-induced neurotoxicity. Aschner, M; Evje, L; Kaur, P; Syversen, T, 2010) | 0.36 |
| " While these results make it unlikely that hemin toxicity is due to interactions with endogenous H(2)O(2), hemin toxicity was increased in the presence of supraphysiological levels of H(2)O(2) and this increase was ameliorated by PHEN, indicating that the iron released from hemin can be toxic under some pathological conditions." | ( The metabolism and toxicity of hemin in astrocytes. Bishop, GM; Dang, TN; Dringen, R; Robinson, SR, 2011) | 0.37 |
| " In this study we compared the effects of CB1 and CB2 receptor-selective ligands, the endocannabinoid anandamide and the phytocannabinoid cannabidiol, against oxidative stress and the toxic hallmark Alzheimer's protein, β-amyloid (Aβ) in neuronal cell lines." | ( Contrasting protective effects of cannabinoids against oxidative stress and amyloid-β evoked neurotoxicity in vitro. Harvey, BS; Mååg, JL; Musgrave, IF; Ohlsson, KS; Smid, SD, 2012) | 0.38 |
| " In conclusion, the nanoparticles containing antioxidant actives were safe for topical use and presented anti-aging activity in vivo and are suitable to be used as cosmetic ingredient." | ( Safety and efficacy of antioxidants-loaded nanoparticles for an anti-aging application. Bruschi, M; Carvalho, AR; Felippi, CC; Oliveira, D; Raffin, RP; Ströher, A; Van Etten, EA, 2012) | 0.38 |
| "01-1000μM) did not show neurotoxicity, 2'-OH- and 4'-OH-deltamethrin (10-1000μM) were more toxic than deltamethrin (10-1000μM)." | ( Cytotoxicity induced by deltamethrin and its metabolites in SH-SY5Y cells can be differentially prevented by selected antioxidants. Anadón, A; Ares, I; Castellano, V; Martínez, M; Martínez, MA; Martínez-Larrañaga, MR; Ramos, E; Romero, A, 2012) | 0.38 |
| " In this study, we investigated the toxic effect of ketamine on neurons differentiated from hESCs." | ( Ketamine induces toxicity in human neurons differentiated from embryonic stem cells via mitochondrial apoptosis pathway. Bai, X; Bosnjak, ZJ; Canfield, S; Corbett, JA; Kikuchi, C; Muravyeva, MY; Wells, CW; Yan, Y, 2012) | 0.38 |
| " We previously identified the toxic conformer of Aβ42 with a turn at positions 22 and 23 ("toxic turn") by solid-state NMR and demonstrated that a monoclonal antibody (11A1) against the toxic turn in Aβ42 mainly detected the oligomer in the brains of AD patients." | ( Toxicity in rat primary neurons through the cellular oxidative stress induced by the turn formation at positions 22 and 23 of Aβ42. Akaike, A; Irie, K; Izumi, Y; Izuo, N; Kume, T; Murakami, K; Sato, M, 2012) | 0.38 |
| " Our evidence suggests that specific organic ligands available in the receiving waters can differentially surface modify AgNPs and alter their environmental persistence (changing dissolution dynamics) and subsequently the toxicity; hence, we caveat to generalize that surface modified nanoparticles upon environmental release may not be toxic to receptor organisms." | ( Impacts of select organic ligands on the colloidal stability, dissolution dynamics, and toxicity of silver nanoparticles. Dubey, B; Pokhrel, LR; Scheuerman, PR, 2013) | 0.39 |
| "T-2 toxin is a highly toxic mycotoxin produced by various Fusarium species, mainly, Fusarium sporotrichoides, and has been reported to have toxic effects on reproductive system of adult male animals." | ( T-2 toxin-induced cytotoxicity and damage on TM3 Leydig cells. Matias, FB; Wu, J; Yi, JE; Yuan, Z, ) | 0.13 |
| " No serious treatment-emergent adverse events were reported." | ( The KHENERGY Study: Safety and Efficacy of KH176 in Mitochondrial m.3243A>G Spectrum Disorders. Beukema, R; Beyrath, J; de Laat, P; Groothuis, J; Hemelaar, P; Janssen, MCH; Koene, S; Pickkers, P; Smeitink, J; Spaans, E; Verhaak, C, 2019) | 0.51 |
| " To address this issue, the adverse effects of Au@PEG on human neuroblastoma SHSY5Y cells were first investigated." | ( Surface Functionalization of Pegylated Gold Nanoparticles with Antioxidants Suppresses Nanoparticle-Induced Oxidative Stress and Neurotoxicity. Du, L; Guan, L; Guo, W; Guo, X; Kang, X; Wu, H; Yang, H; Zhang, X, 2020) | 0.56 |
| Excerpt | Reference | Relevance |
|---|---|---|
| " Reduced NO bioavailability causes the so-called "endothelial dysfunction," which seems to be the common molecular disorder comprising stable atherosclerotic narrowing lesions or acute plaque rupture causing unstable angina or myocardial infarction." | ( Endothelial dysfunction in acute and chronic coronary syndromes: evidence for a pathogenetic role of oxidative stress. Cicchitelli, G; Ferrari, R; Macrì, G; Malagutti, P; Merli, E; Soukhomovskaia, O; Valgimigli, M, 2003) | 0.32 |
| " However, flavonoids are poorly absorbed by humans, and the increase in plasma antioxidant capacity observed after consumption of flavonoid-rich foods often greatly exceeds the increase in plasma flavonoids." | ( The increase in human plasma antioxidant capacity after apple consumption is due to the metabolic effect of fructose on urate, not apple-derived antioxidant flavonoids. Frei, B; Lotito, SB, 2004) | 0.32 |
| " The findings demonstrated herein therefore strongly suggest that the amphiphilic character enhances the bioavailability of the antioxidants and allows for a selective targeting of mitochondria." | ( Fluorinated amphiphilic amino acid derivatives as antioxidant carriers: a new class of protective agents. Böker, J; Durand, G; Hardeland, R; Ortial, S; Pappolla, MA; Poeggeler, B; Polidori, A; Pucci, B, 2006) | 0.33 |
| " N-(1-adamantyl)-2-oxo-chromene-3-carboxamide (8), N-adamantan-1-yl-5-dimethyl-amino-1-naphthalenesulfonic acid (11) and N-(1-cyano-2H-isoindol-2-yl) adamantan-1-amine (12) were found to possess a high degree of multifunctionality with favourable physical-chemical properties for bioavailability and blood-brain barrier permeability." | ( Synthesis and evaluation of fluorescent heterocyclic aminoadamantanes as multifunctional neuroprotective agents. Green, IR; Joubert, J; Malan, SF; van Dyk, S, 2011) | 0.37 |
| " Owing to aldose reductase pharmacophore requirements for an acidic proton, most aldose reductase inhibitors contain an acetic acid moiety, ionized at physiological pH, resulting in poor bioavailability of the drugs." | ( (2-Benzyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-8-yl)-acetic acid: an aldose reductase inhibitor and antioxidant of zwitterionic nature. Juskova, M; Milackova, I; Snirc, V; Stefek, M; Triantos, N; Tsantili-Kakoulidou, A, 2011) | 0.37 |
| " Although oral bioavailability of cyclosporine A (CsA) was decreased by increased first-pass metabolism through CYP3A and P-glycoprotein (P-gp) specifically in the upper small intestine after liver I/R, the mechanism responsible for them remained to be clarified." | ( An antioxidant Trolox restores decreased oral absorption of cyclosporine A after liver ischemia-reperfusion through distinct mechanisms between CYP3A and P-glycoprotein in the small intestine. Ikemura, K; Inoue, K; Iwamoto, T; Mizutani, H; Oka, H; Okuda, M, 2012) | 0.38 |
| " To assess the bioavailability of EM, we examined the in vitro uptake using the Caco-2 human colonic cell line." | ( Extraction of antioxidant components from Bidens pilosa flowers and their uptake by human intestinal Caco-2 cells. Chang, CH; Chyau, CC; Huang, SH; Lee, WC; Peng, CC, 2013) | 0.39 |
| " Here, a new series of orally bioavailable multifunctional antioxidants (MFAO-2s) possessing a 2-diacetylamino-5-hydroxypyrimidine moiety is described." | ( Orally Bioavailable Metal Chelators and Radical Scavengers: Multifunctional Antioxidants for the Coadjutant Treatment of Neurodegenerative Diseases. Kador, PF; Kawada, H, 2015) | 0.42 |
| " Compound 13d, having good in vitro ADME profile and moderate oral bioavailability in mice, showed potent anti-inflammatory activity against hapten-induced contact hypersensitivity reaction in mice following topical and oral administration." | ( Synthesis and biological evaluation of novel orally available 1-phenyl-6-aminouracils containing dimethyldihydrobenzofuranol structure for the treatment of allergic skin diseases. Fujiwara, N; Hasegawa, F; Inoue, Y; Isobe, M; Isobe, Y; Tobe, M; Tsuboi, K, 2016) | 0.43 |
| " However, it has major drawbacks of very poor bioavailability and solubility." | ( An appraisal on recent medicinal perspective of curcumin degradant: Dehydrozingerone (DZG). Hampannavar, GA; Karpoormath, R; Palkar, MB; Shaikh, MS, 2016) | 0.43 |
| " These activities, associated to a good predictive bioavailability and a lack of cytotoxicity, design it as a promising hit for further in vivo investigation." | ( Novel benzylidenephenylpyrrolizinones with pleiotropic activities potentially useful in Alzheimer's disease treatment. Corvaisier, S; Cresteil, T; Dallemagne, P; El Kihel, L; Jourdan, JP; Lecoutey, C; Legay, R; Malzert-Fréon, A; Rochais, C; Since, M; Sopkova-de Oliveira Santos, J, 2016) | 0.43 |
| " In that respect, augmenting the water solubility by structural modification of the curcumin scaffold may result in improved bioavailability and pharmacokinetics." | ( Synthesis and biological assessment of novel N-(hydroxy/methoxy)alkyl β-enaminone curcuminoids. D'hooghe, M; De Vreese, R; Grootaert, C; Theppawong, A; Van Camp, J; Vannecke, L, 2016) | 0.43 |
| Role | Description |
|---|---|
| antioxidant | A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides. |
| radical scavenger | A role played by a substance that can react readily with, and thereby eliminate, radicals. |
| Wnt signalling inhibitor | A substance that inhibits any of the Wnt signalling pathway, a group of signal transduction pathways made of proteins that pass signals from outside of a cell through cell surface receptors to the inside of the cell. |
| neuroprotective agent | Any compound that can be used for the treatment of neurodegenerative disorders. |
| ferroptosis inhibitor | Any substance that inhibits the process of ferroptosis (a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides) in organisms. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Class | Description |
|---|---|
| chromanol | Any member of the class of chromanes that is chromane substituted by one or more hydroxy groups. |
| phenols | Organic aromatic compounds having one or more hydroxy groups attached to a benzene or other arene ring. |
| monocarboxylic acid | An oxoacid containing a single carboxy group. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 7.9433 | 0.0447 | 17.8581 | 100.0000 | AID485294 |
| GLS protein | Homo sapiens (human) | Potency | 7.9433 | 0.3548 | 7.9355 | 39.8107 | AID624170 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 14.1254 | 0.0355 | 20.9770 | 89.1251 | AID504332 |
| geminin | Homo sapiens (human) | Potency | 1.8117 | 0.0046 | 11.3741 | 33.4983 | AID624296; AID624297 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Polyphenol oxidase 2 | Agaricus bisporus | IC50 (µMol) | 200.0000 | 0.0340 | 3.9871 | 10.0000 | AID635123 |
| Acetylcholinesterase | Homo sapiens (human) | IC50 (µMol) | 2,090.7000 | 0.0000 | 0.9332 | 10.0000 | AID1256880; AID1802996 |
| Prostaglandin G/H synthase 1 | Homo sapiens (human) | IC50 (µMol) | 0.1300 | 0.0002 | 1.5574 | 10.0000 | AID295042 |
| Sodium-dependent dopamine transporter | Rattus norvegicus (Norway rat) | IC50 (µMol) | 1,000.0000 | 0.0007 | 0.9774 | 9.7000 | AID295044 |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | IC50 (µMol) | 6.6250 | 0.0001 | 0.9950 | 10.0000 | AID240679; AID295043 |
| Xanthine dehydrogenase/oxidase | Homo sapiens (human) | IC50 (µMol) | 1,000.0000 | 0.0013 | 2.8138 | 9.8200 | AID295041 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1381601 | Antioxidant activity assessed as DPPH radical scavenging activity at 100 uM after 30 mins dark incubation | 2018 | European journal of medicinal chemistry, Feb-25, Volume: 146 | Design, synthesis, mechanistic and histopathological studies of small-molecules of novel indole-2-carboxamides and pyrazino[1,2-a]indol-1(2H)-ones as potential anticancer agents effecting the reactive oxygen species production. |
| AID551406 | Antioxidant activity of the compound assessed as DPPH radical scavenging activity at 0.5 mM after 2 hrs | 2011 | Bioorganic & medicinal chemistry, Jan-15, Volume: 19, Issue:2 | Synthesis, structure, theoretical and experimental in vitro antioxidant/pharmacological properties of α-aryl, N-alkyl nitrones, as potential agents for the treatment of cerebral ischemia. |
| AID19477 | Partition coefficient (logD) (octanol/phosphate buffer) | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1 | A cardioselective, hydrophilic N,N,N-trimethylethanaminium alpha-tocopherol analogue that reduces myocardial infarct size. |
| AID1152637 | Antioxidant activity assessed as hydroxyl radical scavenging activity at 5 uM after 1 hr by 2-Deoxy-D-ribose degradation assay in presence of FeCl3 | 2014 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 24, Issue:12 | Synthesis and radical scavenging activity of phenol-imidazole conjugates. |
| AID469415 | Neuroprotective activity against human SH-SY5Y cells assessed as cytoprotection at 1 uM coincubated with rotenone/oligomycin A measured after 24 hrs | 2009 | Journal of medicinal chemistry, Nov-26, Volume: 52, Issue:22 | Neuroprotective and cholinergic properties of multifunctional glutamic acid derivatives for the treatment of Alzheimer's disease. |
| AID1581656 | Antioxidant activity assessed as ABTS radical scavenging activity at 30 uM measured after 60 mins by spectrophotometric assay relative to control | 2020 | European journal of medicinal chemistry, Feb-01, Volume: 187 | 1-Benzylpyrrolidine-3-amine-based BuChE inhibitors with anti-aggregating, antioxidant and metal-chelating properties as multifunctional agents against Alzheimer's disease. |
| AID195554 | The IC50 value was measured for inhibition of lipid autoxidation in rat brain homogenate. | 1995 | Journal of medicinal chemistry, Jul-21, Volume: 38, Issue:15 | Cardioselective ammonium, phosphonium, and sulfonium analogues of alpha-tocopherol and ascorbic acid that inhibit in vitro and ex vivo lipid peroxidation and scavenge superoxide radicals. |
| AID257313 | DPPH radical scavenging activity of Cudriana tricuspidata extracts | 2005 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 15, Issue:24 | Antioxidant and cytotoxic activities of xanthones from Cudrania tricuspidata. |
| AID504307 | Antioxidant activity assessed as superoxide radical scavenging activity by chemiluminescence analysis | 2010 | Journal of natural products, Sep-24, Volume: 73, Issue:9 | Antioxidant and anti-inflammatory phenylpropanoid derivatives from Calamus quiquesetinervius. |
| AID269151 | Antioxidant activity assessed as ability to scavenge hydroxyl radicals by ABTS competition assay | 2006 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 16, Issue:15 | Solid-phase synthesis of quinol fatty alcohols, design of N/O-substituted quinol fatty alcohols and comparative activities on axonal growth. |
| AID444235 | Cytoprotection in human SRA1 cells assessed as protection against H2O2-induced cell death after 2 hrs by MTS assay | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3 | Multifunctional antioxidants for the treatment of age-related diseases. |
| AID257903 | Antioxidant potency assessed chemically | 2006 | Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1 | Chroman/catechol hybrids: synthesis and evaluation of their activity against oxidative stress induced cellular damage. |
| AID1493970 | Antiproliferative activity against human T47D cells after 48 hrs by SRB assay | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | A green multicomponent synthesis of tocopherol analogues with antiproliferative activities. |
| AID103204 | Compound was tested for antiproliferative activity against human breast cancer cell line MCF-7 in MTT assay | 1998 | Bioorganic & medicinal chemistry letters, Sep-22, Volume: 8, Issue:18 | Design and synthesis of analogs of vitamin E: antiproliferative activity against human breast adenocarcinoma cells. |
| AID203485 | Glycation-induced fluorescence changes of bovine serum albumin when exposed to fructose (1 mM); p<0.001 | 2003 | Journal of medicinal chemistry, Jan-30, Volume: 46, Issue:3 | Substituted pyrrol-1-ylacetic acids that combine aldose reductase enzyme inhibitory activity and ability to prevent the nonenzymatic irreversible modification of proteins from monosaccharides. |
| AID1493968 | Antiproliferative activity against human SW1573 cells after 48 hrs by SRB assay | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | A green multicomponent synthesis of tocopherol analogues with antiproliferative activities. |
| AID736487 | Antioxidant activity assessed as inhibition of DPPH radical formation measured every min for 45 mins by spectrophotometric analysis | 2013 | European journal of medicinal chemistry, Apr, Volume: 62 | Exploring nature profits: development of novel and potent lipophilic antioxidants based on galloyl-cinnamic hybrids. |
| AID541259 | Inhibition of AAPH-induced linoleic acid lipid peroxidation | 2010 | Journal of medicinal chemistry, Dec-09, Volume: 53, Issue:23 | 1,5-Benzoxazepines vs 1,5-benzodiazepines. one-pot microwave-assisted synthesis and evaluation for antioxidant activity and lipid peroxidation inhibition. |
| AID444242 | Antioxidant activity in human HAh cells assessed as inhibition of Fenton's reagent-induced reduction of cellular glutathione level after 2 hrs by DTNB method | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3 | Multifunctional antioxidants for the treatment of age-related diseases. |
| AID536049 | Antioxidant activity assessed as protection against 340 Gy gamma-radiation-induced thymidine degradation in 12.5 mM phosphate buffer at 50 uM by competitive immuno-enzymatic assay | 2010 | Bioorganic & medicinal chemistry, Nov-15, Volume: 18, Issue:22 | Synthesis and antioxidant properties of pulvinic acids analogues. |
| AID218991 | Oxidation was assessed indirectly by measuring bovine serum albumin (BSA) thiol protection from the formation of thiobarbituric acid reactive substances (TBARs) by TBARs test at 10 uM | 2002 | Bioorganic & medicinal chemistry letters, Jan-21, Volume: 12, Issue:2 | New series of aryloxypropanolamines with both human beta(3)-adrenoceptor agonistic activity and free radical scavenging properties. |
| AID1713228 | Cytotoxicity against human SH-SY5Y cells assessed as cell viability at 12.5 uM measured after 2 hrs by MTT assay relative to control | 2016 | European journal of medicinal chemistry, Nov-10, Volume: 123 | Synthesis and in vitro, ex-vivo and in vivo activity of hybrid compounds linking a potent ROS and RNS scavenger activity with diverse substrates addressed to pass across the blood-brain barrier. |
| AID459654 | Cytotoxicity against human MRC5 cells assessed as plasma membrane damage at 60 uM after 7 days by LDH assay | 2010 | Bioorganic & medicinal chemistry, Mar-01, Volume: 18, Issue:5 | Exploring a synthetic organoselenium compound for antioxidant pharmacotherapy--toxicity and effects on ROS-production. |
| AID1179730 | Cytoprotection in mouse CRL2181 cells assessed as reduction in UV-oxidized LDL-induced cytotoxicity by measuring cell viability at 10 uM after 24 hrs by MTT assay relative to untreated control | 2014 | Bioorganic & medicinal chemistry, Aug-01, Volume: 22, Issue:15 | Synthesis, antioxidant and cytoprotective evaluation of potential antiatherogenic phenolic hydrazones. A structure-activity relationship insight. |
| AID1357814 | Neuroprotective activity against H2O2-induced oxidative stress in human SH-SY5Y cells assessed as cell viability at 25 uM pre-incubated for 1 hr followed by H2O2 addition and measured after 4 hrs by MTT assay relative to control | 2018 | European journal of medicinal chemistry, May-10, Volume: 151 | Novel sarsasapogenin-triazolyl hybrids as potential anti-Alzheimer's agents: Design, synthesis and biological evaluation. |
| AID1564979 | Antioxidant activity assessed as DPPH radical scavenging activity measured after 120 mins | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Novel multi target-directed ligands targeting 5-HT |
| AID1651391 | Neuroprotective activity against H2O2-induced cell death in human SH-SY5Y cells assessed as cell viability at 25 uM preincubated for 1 hr followed by H2O2 addition and measured after 4 hrs by CCK8 assay (Rvb = 61.14 +/- 1.05%) | 2020 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 30, Issue:4 | Isolation of triterpenoid saponins from Medicago sativa L. with neuroprotective activities. |
| AID445117 | Prooxidant effect on Cu2+-induced pBR322 DNA damage at 0.35 to 45 uM after 1 hr | 2009 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 19, Issue:22 | Synthesis and antioxidant properties of dendritic polyphenols. |
| AID459650 | Cytotoxicity against human Caco-2 cells assessed as cell death at 60 uM after 7 days by LDH assay | 2010 | Bioorganic & medicinal chemistry, Mar-01, Volume: 18, Issue:5 | Exploring a synthetic organoselenium compound for antioxidant pharmacotherapy--toxicity and effects on ROS-production. |
| AID1335587 | Antioxidant activity assessed as inhibition of AAPH-induced linoleic acid lipid peroxidation at 1 x 10'-4 M by UV-absorbance method relative to control | 2016 | European journal of medicinal chemistry, Nov-29, Volume: 124 | Novel urea and bis-urea primaquine derivatives with hydroxyphenyl or halogenphenyl substituents: Synthesis and biological evaluation. |
| AID264479 | Lipophilicity, log k'w of the compound | 2006 | Journal of medicinal chemistry, May-04, Volume: 49, Issue:9 | Fluorinated amphiphilic amino acid derivatives as antioxidant carriers: a new class of protective agents. |
| AID639373 | Neuroprotective activity against rotenone/oligomycin A-induced cell death in human SH-SY5Y cells assessed as LDH release at 0.3 uM treated 24 hrs before rotenone/oligomycin A challenge measured after 24 hrs relative to control | 2011 | European journal of medicinal chemistry, Jun, Volume: 46, Issue:6 | N-acylaminophenothiazines: neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease. |
| AID490944 | Antioxidant activity assessed as DPPH radical scavenging activity at 50 uM after 60 mins | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Synthesis and biological screening of some novel amidocarbamate derivatives of ketoprofen. |
| AID639458 | Neuroprotective activity against rotenone/oligomycin A-induced cell death in human SH-SY5Y cells assessed as LDH release at 0.3 uM after 24 hrs relative to control | 2011 | European journal of medicinal chemistry, Jun, Volume: 46, Issue:6 | N-acylaminophenothiazines: neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease. |
| AID1325285 | Antioxidant activity assessed as ABTS radical scavenging activity after 30 mins | 2016 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 26, Issue:22 | Antioxidant and anti-inflammatory neolignans from the seeds of hawthorn. |
| AID1424234 | Antioxidant activity assessed as singlet oxygen scavenging activity by measuring rate constant using VIS irradiation by ESR spin trapping method | 2017 | European journal of medicinal chemistry, Jun-16, Volume: 133 | Free radicals and polyphenols: The redox chemistry of neurodegenerative diseases. |
| AID196393 | Compound was evaluated for its inhibitory concentration against hydrogen peroxide- induced oxidative neuronal damage in primary cultured rat cortical cells | 2002 | Bioorganic & medicinal chemistry letters, Sep-16, Volume: 12, Issue:18 | Synthesis and evaluation of 4-hydroxyphenylacetic acid amides and 4-hydroxycinnamamides as antioxidants. |
| AID1892624 | Antioxidant activity in rat brain homogenate assessed as inhibition of lipid peroxidation by measuring MDA concentration at 10 uM relative to control | 2022 | Journal of medicinal chemistry, 07-14, Volume: 65, Issue:13 | Novel Hydroxychalcone-Based Dual Inhibitors of Aldose Reductase and α-Glucosidase as Potential Therapeutic Agents against Diabetes Mellitus and Its Complications. |
| AID604215 | Antioxidant activity assessed as inhibition of ABTS free radicals at 1 mM after 30 mins by UV-visible spectrophotometer analysis relative to control | 2011 | Bioorganic & medicinal chemistry, Jul-01, Volume: 19, Issue:13 | Synthesis and evaluation of fluorescent heterocyclic aminoadamantanes as multifunctional neuroprotective agents. |
| AID708013 | Inhibition of AAPH-induced oxidative stress in human U373MG cells assessed as peroxy radical scavenging activity at 8 uM by ORAC assay | 2012 | Journal of natural products, Oct-26, Volume: 75, Issue:10 | Diterpenoids isolated from Sideritis species protect astrocytes against oxidative stress via Nrf2. |
| AID1326574 | Cytotoxicity against human MT4 cells assessed as reduction in cell viability after 72 hrs by MTT assay | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Antioxidant and antitumor activity of trolox, trolox succinate, and α-tocopheryl succinate conjugates with nitroxides. |
| AID490420 | Cytoprotective activity against cell-mediated LDL oxidation in HMEC1 cells at 10 uM after 6 hrs by MTT assay | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Synthesis and antioxidant activity evaluation of a syringic hydrazones family. |
| AID1298953 | Antioxidant activity assessed as DPPH free radical scavenging activity at 100 uM after 40 mins by UV-Vis spectrophotometry | 2016 | Bioorganic & medicinal chemistry letters, 06-15, Volume: 26, Issue:12 | Synthesis of benzothiadiazine derivatives exhibiting dual activity as aldose reductase inhibitors and antioxidant agents. |
| AID1325287 | Antioxidant activity assessed as ferric ion reducing activity by measuring Fe2+ levels using fe3+-TPTZ at 750 ug/ml after 30 mins by FRAP assay | 2016 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 26, Issue:22 | Antioxidant and anti-inflammatory neolignans from the seeds of hawthorn. |
| AID1465117 | Antioxidant activity assessed as ABTS radical cation scavenging activity by measuring trolox equivalents at 20 uM after 1 hr by UV/Vis spectrophotometric method-based ABTS radical cation decolorization assay | 2017 | Bioorganic & medicinal chemistry, 11-01, Volume: 25, Issue:21 | 9-Substituted acridine derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors possessing antioxidant activity for Alzheimer's disease treatment. |
| AID1198127 | Antioxidant activity assessed as DPPH scavenging activity after 30 mins by spectrophotometry | 2015 | European journal of medicinal chemistry, Mar-26, Volume: 93 | Multifunctional tacrine-trolox hybrids for the treatment of Alzheimer's disease with cholinergic, antioxidant, neuroprotective and hepatoprotective properties. |
| AID634729 | Antioxidant activity assessed as inhibition of DPPH free radical scavenging activity | 2012 | European journal of medicinal chemistry, Jan, Volume: 47, Issue:1 | Bis-chalcone analogues as potent NO production inhibitors and as cytotoxic agents. |
| AID431301 | Antioxidant activity assessed as inhibition of AAPH-induced lipid peroxidation at 0.1 mM | 2009 | Bioorganic & medicinal chemistry, Aug-01, Volume: 17, Issue:15 | Urea and carbamate derivatives of primaquine: synthesis, cytostatic and antioxidant activities. |
| AID1678099 | Antioxidant activity assessed as DPPH radical scavenging activity at 100 uM relative to control | 2020 | Bioorganic & medicinal chemistry, 10-15, Volume: 28, Issue:20 | Dihydrobenzoxazinone derivatives as aldose reductase inhibitors with antioxidant activity. |
| AID1402942 | Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced ROS production measured after 4 hrs by H2DCFDA-AM probe based fluorescence assay | 2018 | European journal of medicinal chemistry, Jan-20, Volume: 144 | Synthesis and biological evaluation of diarylheptanoids as potential antioxidant and anti-inflammatory agents. |
| AID1610480 | Inhibition of porcine liver carboxylesterase at 20 uM using 4-NPA as substrate preincubated for 10 mins followed by substrate addition by spectrophotometric analysis relative to control | 2019 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 29, Issue:23 | Synthesis of 2-arylhydrazinylidene-3-oxo-4,4,4-trifluorobutanoic acids as new selective carboxylesterase inhibitors and radical scavengers. |
| AID604211 | Antioxidant activity assessed as inhibition of DPPH free radicals at 0.1 mM after 30 mins by UV-visible spectrophotometer analysis relative to control | 2011 | Bioorganic & medicinal chemistry, Jul-01, Volume: 19, Issue:13 | Synthesis and evaluation of fluorescent heterocyclic aminoadamantanes as multifunctional neuroprotective agents. |
| AID619941 | Antioxidant activity assessed as ferric to ferrous reduction at 20 ug/ml by FRAP assay | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9 | Isoeugenol-based novel potent antioxidants: synthesis and reactivity. |
| AID1465118 | Antioxidant activity assessed as ABTS radical cation scavenging activity after 1 hr by UV/Vis spectrophotometric method-based ABTS radical cation decolorization assay | 2017 | Bioorganic & medicinal chemistry, 11-01, Volume: 25, Issue:21 | 9-Substituted acridine derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors possessing antioxidant activity for Alzheimer's disease treatment. |
| AID1474959 | Antioxidant activity assessed as ABTS radical scavenging activity at 3 mg/ml incubated for 2 hrs in dark by spectrophotometric analysis (Rvb = 1 to 9%) | 2017 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11 | Stereoselective synthesis of enantiopure N-substituted pyrrolidin-2,5-dione derivatives by 1,3-dipolar cycloaddition and assessment of their in vitro antioxidant and antibacterial activities. |
| AID625355 | Antioxidant activity assessed as inhibition of AAPH-induced lipid peroxidation at 100 uM | 2011 | European journal of medicinal chemistry, Dec, Volume: 46, Issue:12 | Synthesis and biological evaluation of (2,5-dihydro-1H-pyrrol-1-yl)-2H-chromen-2-ones as free radical scavengers. |
| AID1143754 | Inhibition of calcium channel in human SH-SY5Y cells assessed as blockade of K+-evoked cytosolic calcium increase at 3 uM after 15 mins using Fluo-4/AM by fluorescence microplate reader analysis | 2014 | European journal of medicinal chemistry, Jun-23, Volume: 81 | Dibenzo[1,4,5]thiadiazepine: a hardly-known heterocyclic system with neuroprotective properties of potential usefulness in the treatment of neurodegenerative diseases. |
| AID1179762 | Ratio of compound IC50 to trolox IC50 for ABTS radical scavenging activity after 12 hrs by spectrophotometry | 2014 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15 | Phenylpropanoid acid esters from Korean propolis and their antioxidant activities. |
| AID1581654 | Antioxidant activity assessed as ABTS radical scavenging activity at 75 uM measured after 30 mins by spectrophotometric assay relative to control | 2020 | European journal of medicinal chemistry, Feb-01, Volume: 187 | 1-Benzylpyrrolidine-3-amine-based BuChE inhibitors with anti-aggregating, antioxidant and metal-chelating properties as multifunctional agents against Alzheimer's disease. |
| AID1326580 | Cytotoxicity against human CEM13 cells assessed as reduction in cell viability at 300 uM after 72 hrs by MTT assay | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Antioxidant and antitumor activity of trolox, trolox succinate, and α-tocopheryl succinate conjugates with nitroxides. |
| AID1242923 | Antioxidant activity in rat brain assessed as inhibition of MDA production at 100 uM by TBARS assay relative to control | 2015 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 25, Issue:18 | Phenolic 4-hydroxy and 3,5-dihydroxy derivatives of 3-phenoxyquinoxalin-2(1H)-one as potent aldose reductase inhibitors with antioxidant activity. |
| AID381849 | DPPH radical scavenging activity | 2008 | Bioorganic & medicinal chemistry, Apr-01, Volume: 16, Issue:7 | Design and synthesis of N-(3,5-difluoro-4-hydroxyphenyl)benzenesulfonamides as aldose reductase inhibitors. |
| AID1264041 | Neuroprotective activity against Fenton reagent-induced hydroxy radical-stimulated cytotoxicity in human SH-SY5Y cells assessed as cell survival at 1 to 1000 uM preincubated for 1 hr followed by Fenton reagent challenge for 2 hrs by fluorescence-based LIV | 2015 | Journal of medicinal chemistry, Nov-25, Volume: 58, Issue:22 | Orally Bioavailable Metal Chelators and Radical Scavengers: Multifunctional Antioxidants for the Coadjutant Treatment of Neurodegenerative Diseases. |
| AID1143747 | Neuroprotective activity in human SH-SY5Y cells assessed as protection against rotenone-oligomycin-induced toxicity at 0.3 uM preincubated for 24 hrs before rotenone-oligomycin addition measured after 24 hrs by lactate dehydrogenase release assay | 2014 | European journal of medicinal chemistry, Jun-23, Volume: 81 | Dibenzo[1,4,5]thiadiazepine: a hardly-known heterocyclic system with neuroprotective properties of potential usefulness in the treatment of neurodegenerative diseases. |
| AID228133 | Reaction rate constant of the compound | 2001 | Bioorganic & medicinal chemistry letters, Sep-03, Volume: 11, Issue:17 | Imidazolopyrazinones as potential antioxidants. |
| AID196902 | Effect of compound on in vitro accumulation of MDA content in heart at concentration of 5 uM | 2001 | Journal of medicinal chemistry, Nov-22, Volume: 44, Issue:24 | Novel potent inhibitors of lipid peroxidation with protective effects against reperfusion arrhythmias. |
| AID1179729 | Antioxidant activity assessed as reduction in mouse CRL2181 cells-mediated human LDL oxidation by measuring TBARS level at 1 uM after 18 hrs | 2014 | Bioorganic & medicinal chemistry, Aug-01, Volume: 22, Issue:15 | Synthesis, antioxidant and cytoprotective evaluation of potential antiatherogenic phenolic hydrazones. A structure-activity relationship insight. |
| AID619934 | Antioxidant activity assessed as inhibition of linoleic acid lipid peroxidation at 100 ug/ml measured after 24 hrs by ferric thiocynate method | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9 | Isoeugenol-based novel potent antioxidants: synthesis and reactivity. |
| AID81332 | Compound was evaluated for in vitro inhibition of proliferation measured by inhibition of [3H]thymidine incorporation by HMVEC-L cells | 1999 | Journal of medicinal chemistry, Jan-28, Volume: 42, Issue:2 | Novel esters and amides of nonsteroidal antiinflammatory carboxylic acids as antioxidants and antiproliferative agents. |
| AID247976 | Inhibition concentration against DPPH radical scavenging activity in rat was determined | 2005 | Bioorganic & medicinal chemistry letters, Jun-02, Volume: 15, Issue:11 | Synthesis and evaluation of 6-hydroxy-7-methoxy-4-chromanone- and chroman-2-carboxamides as antioxidants. |
| AID1256875 | Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins by microplate reader analysis | 2015 | Journal of medicinal chemistry, Nov-25, Volume: 58, Issue:22 | Tacrine-Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity. |
| AID1456006 | Antioxidant activity assessed as DPPH radical scavenging activity measured after 30 mins | 2017 | European journal of medicinal chemistry, Apr-21, Volume: 130 | Design, synthesis and evaluation of novel feruloyl-donepezil hybrids as potential multitarget drugs for the treatment of Alzheimer's disease. |
| AID567051 | Antioxidant activity assessed as inhibition of linoleic acid peroxidation at 0.1 mM by AAPH assay | 2011 | European journal of medicinal chemistry, Jan, Volume: 46, Issue:1 | Design, synthesis and pharmacobiological evaluation of novel acrylic acid derivatives acting as lipoxygenase and cyclooxygenase-1 inhibitors with antioxidant and anti-inflammatory activities. |
| AID1581659 | Antioxidant activity assessed as increase in total ferric ion reducing activity at 30 uM using FeCl3.H2O and TPTZ incubated for 5 mins by FRAP assay relative to control | 2020 | European journal of medicinal chemistry, Feb-01, Volume: 187 | 1-Benzylpyrrolidine-3-amine-based BuChE inhibitors with anti-aggregating, antioxidant and metal-chelating properties as multifunctional agents against Alzheimer's disease. |
| AID1083341 | Antiviral activity against Sindbis virus infected Hela cells assessed as inhibition of virus-induced cytopathicity | 2011 | Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, , Volume: 20, Issue:2 | The novel amidocarbamate derivatives of ketoprofen: synthesis and biological activity. |
| AID1179732 | Antioxidant activity assessed as superoxide anion radical scavenging activity at 10 uM by PMS-NADH-NBT system based spectrophotometry | 2014 | Bioorganic & medicinal chemistry, Aug-01, Volume: 22, Issue:15 | Synthesis, antioxidant and cytoprotective evaluation of potential antiatherogenic phenolic hydrazones. A structure-activity relationship insight. |
| AID1485933 | Neuroprotective activity against H2O2-induced cell death in rat PC12 cells assessed as increase in cell viability at 10 uM pretreated for 24 hrs followed by H2O2 induction after 24 hrs by MTT assay | 2017 | Bioorganic & medicinal chemistry, 07-15, Volume: 25, Issue:14 | Synthesis and pharmacological evaluation of novel chromone derivatives as balanced multifunctional agents against Alzheimer's disease. |
| AID451365 | Antioxidant activity assessed as inhibition of Fe3+ ion-induced 2-deoxyribose oxidation after 24 hrs by TBA method | 2009 | Bioorganic & medicinal chemistry, Sep-01, Volume: 17, Issue:17 | Antioxidant efficacy of iridoid and phenylethanoid glycosides from the medicinal plant Teucrium chamaedris in cell-free systems. |
| AID1333939 | Oxidation potential of compound against Ag/Agcl reference electrode at 1 mM by cyclic voltametry | 2017 | Bioorganic & medicinal chemistry, 01-15, Volume: 25, Issue:2 | Synthesis, antioxidant and antichagasic properties of a selected series of hydroxy-3-arylcoumarins. |
| AID1372025 | Antioxidant activity assessed as relative scavenging rate constant for photolysis-induced hydroxyl radical scavenging activity by measuring Kaox/Kst ratio using DMPO spin trap by ESR spectroscopic method | 2017 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23 | Resveratrol analogues like piceatannol are potent antioxidants as quantitatively demonstrated through the high scavenging ability against reactive oxygen species and methyl radical. |
| AID469404 | Neuroprotective activity against human SH-SY5Y cells assessed as protection reduction in H2O2-induced LDH release at 1 uM after 24 hrs | 2009 | Journal of medicinal chemistry, Nov-26, Volume: 52, Issue:22 | Neuroprotective and cholinergic properties of multifunctional glutamic acid derivatives for the treatment of Alzheimer's disease. |
| AID1083350 | Antioxidant activity assessed as DPPH radical scavenging activity at 1 X 10'-4 M after 60 min | 2011 | Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, , Volume: 20, Issue:2 | The novel amidocarbamate derivatives of ketoprofen: synthesis and biological activity. |
| AID548349 | Neuroprotective activity against H2O2-induced oxidative stress in human SH-SY5Y cells assessed as LDH release at 60 uM after 24 hrs by UV-vis spectroscopy | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | Old phenothiazine and dibenzothiadiazepine derivatives for tomorrow's neuroprotective therapies against neurodegenerative diseases. |
| AID1428457 | Inhibition of Acyrthosiphon pisum phenoloxidase using L-DOPA as substrate preincubated for 5 mins followed by substrate addition measured after 120 to 240 mins by spectrophotometric method | 2016 | Journal of natural products, Dec-23, Volume: 79, Issue:12 | Antioxidant Flavonols and Phenolic Compounds from Atraphaxis frutescens and Their Inhibitory Activities against Insect Phenoloxidase and Mushroom Tyrosinase. |
| AID1256118 | Antioxidant activity in rat PC12 cells assessed as inhibition of Fe2+-induced reactive oxygen species formation after 1 hr by DCFH-DA dye-based fluorometric analysis | 2015 | Journal of medicinal chemistry, Nov-12, Volume: 58, Issue:21 | Identification of Highly Promising Antioxidants/Neuroprotectants Based on Nucleoside 5'-Phosphorothioate Scaffold. Synthesis, Activity, and Mechanisms of Action. |
| AID195539 | Compound was tested for 50% Inhibition of lipid peroxidation in rat brain homogenate | 2000 | Journal of medicinal chemistry, Jul-27, Volume: 43, Issue:15 | 3,5-Disubstituted-4-hydroxyphenyls linked to 3-hydroxy-2-methyl-4(1H)-pyridinone: potent inhibitors of lipid peroxidation and cell toxicity. |
| AID745285 | Antioxidant activity assessed as Fe3+/ascorbic acid-induced hydroxyl radical scavenging activity at 100 uM after 30 mins | 2013 | European journal of medicinal chemistry, May, Volume: 63 | Analysis of the antioxidant properties of differently substituted 2- and 3-indolyl carbohydrazides and related derivatives. |
| AID1174517 | Antioxidant activity assessed as radical scavenging activity after 1 hr by ABTS competition assay | 2015 | European journal of medicinal chemistry, Jan-07, Volume: 89 | Neuroprotective effects of a brain permeant 6-aminoquinoxaline derivative in cell culture conditions that model the loss of dopaminergic neurons in Parkinson disease. |
| AID604216 | Antioxidant activity assessed as inhibition of DPPH free radicals after 30 mins by UV-visible spectrophotometer analysis relative to control | 2011 | Bioorganic & medicinal chemistry, Jul-01, Volume: 19, Issue:13 | Synthesis and evaluation of fluorescent heterocyclic aminoadamantanes as multifunctional neuroprotective agents. |
| AID736291 | Antioxidant activity assessed as ABTS free radical scavenging activity measured up to 6 mins by spectrophotometric analysis | 2013 | Journal of natural products, Apr-26, Volume: 76, Issue:4 | Antioxidant and anti-inflammatory meroterpenoids from the brown alga Cystoseira usneoides. |
| AID459652 | Cytotoxicity against HEK293 cells assessed as plasma membrane damage at 60 uM after 7 days by LDH assay | 2010 | Bioorganic & medicinal chemistry, Mar-01, Volume: 18, Issue:5 | Exploring a synthetic organoselenium compound for antioxidant pharmacotherapy--toxicity and effects on ROS-production. |
| AID1486134 | Antioxidant activity assessed as ABTS radical cation scavenging activity by measuring trolox equivalent antioxidant capacity after 1 hr by UV/Vis spectrophotometric analysis | 2017 | Bioorganic & medicinal chemistry, 08-01, Volume: 25, Issue:15 | Synthesis, molecular docking, and biological activity of polyfluoroalkyl dihydroazolo[5,1-c][1,2,4]triazines as selective carboxylesterase inhibitors. |
| AID1603221 | Antioxidant activity in rat brain homogenate assessed as inhibition of FeCl2/ascorbic acid-induced lipid peroxidation by measuring reduction in TBARS level at 100 uM measured after 30 mins by spectrophotometric method relative to control | 2019 | Bioorganic & medicinal chemistry, 04-15, Volume: 27, Issue:8 | Designing of acyl sulphonamide based quinoxalinones as multifunctional aldose reductase inhibitors. |
| AID392746 | Antioxidant activity assessed as inhibition of AAPH-induced lipid peroxidation at 100 uM | 2009 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 19, Issue:4 | Synthesis of hydroxycoumarins and hydroxybenzo[f]- or [h]coumarins as lipid peroxidation inhibitors. |
| AID1306592 | Antioxidant activity in HMEC1 assessed as inhibition of cell induced LDL oxidation by measuring TBARS level at 1 uM relative to control | 2016 | Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16 | Synthesis and evaluation of antioxidant phenolic diaryl hydrazones as potent antiangiogenic agents in atherosclerosis. |
| AID1311886 | Antioxidant activity in human SH-SY5Y cells assessed as inhibition of H2O2-induced ROS production preincubated for 1 day prior H2O2 treatment at 25 uM by DCFH-DA-based fluorescence analysis | 2016 | Bioorganic & medicinal chemistry, 09-15, Volume: 24, Issue:18 | Design, synthesis, and evaluation of Trolox-conjugated amyloid-β C-terminal peptides for therapeutic intervention in an in vitro model of Alzheimer's disease. |
| AID736009 | Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins by microplate reader | 2013 | Journal of natural products, Feb-22, Volume: 76, Issue:2 | Flavone tetraglycosides and benzyl alcohol glycosides from the Mongolian medicinal plant Dracocephalum ruyschiana. |
| AID1365821 | Antioxidant activity in rat hepatic microsomes assessed as inhibition of FeSO4-induced lipid peroxidation measured after 45 mins by spectrophotometry | 2017 | Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21 | Dual antioxidant structures with potent anti-inflammatory, hypolipidemic and cytoprotective properties. |
| AID619938 | Antioxidant activity assessed as residual ABTS+ radical scavenging activity after 30 mins by spectrophotometric analysis | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9 | Isoeugenol-based novel potent antioxidants: synthesis and reactivity. |
| AID1083351 | Antioxidant activity assessed as DPPH radical scavenging activity at 1 X 10'-4 M after 20 min | 2011 | Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, , Volume: 20, Issue:2 | The novel amidocarbamate derivatives of ketoprofen: synthesis and biological activity. |
| AID463458 | Antioxidant activity against peroxynitrite-induced tyrosine nitration after 15 mins by HPLC | 2010 | European journal of medicinal chemistry, Mar, Volume: 45, Issue:3 | New pyrazoles incorporating pyrazolylpyrazole moiety: synthesis, anti-HCV and antitumor activity. |
| AID264673 | Hydroxyl radical scavenging activity by ABTS assay | 2006 | Bioorganic & medicinal chemistry letters, May-15, Volume: 16, Issue:10 | Quinol fatty alcohols as promoters of axonal growth. |
| AID381850 | Antioxidant activity assessed as inhibition of DOPC liposomes | 2008 | Bioorganic & medicinal chemistry, Apr-01, Volume: 16, Issue:7 | Design and synthesis of N-(3,5-difluoro-4-hydroxyphenyl)benzenesulfonamides as aldose reductase inhibitors. |
| AID363319 | Antioxidant activity assessed as inhibition of peroxynitrite-induced evans blue bleaching at 50 uM | 2008 | European journal of medicinal chemistry, Jun, Volume: 43, Issue:6 | Synthesis and biological activities of a series of 4,5-diaryl-3-hydroxy-2(5H)-furanones. |
| AID774817 | Antioxidant activity assessed as DPPH free radical scavenging activity after 30 mins by spectrophotometric analysis | 2013 | Bioorganic & medicinal chemistry, Nov-01, Volume: 21, Issue:21 | Synthesis and antioxidant activity of novel Mannich base of 1,3,4-oxadiazole derivatives possessing 1,4-benzodioxan. |
| AID1083337 | Antiviral activity against Vesicular stomatitis virus infected HEL cells assessed as inhibition of virus-induced cytopathicity | 2011 | Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, , Volume: 20, Issue:2 | The novel amidocarbamate derivatives of ketoprofen: synthesis and biological activity. |
| AID1238055 | Antioxidant activity assessed as nitric oxide radical scavenging activity at 500 uM incubated for 60 mins with light exposure at room temperature by Griess assay | 2015 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 25, Issue:16 | Nitric oxide inhibitory activity and antioxidant evaluations of 2-benzoyl-6-benzylidenecyclohexanone analogs, a novel series of curcuminoid and diarylpentanoid derivatives. |
| AID1755236 | Inhibition of amyloid beta (1 to 42) (unknown origin) self-induced aggregation at 20 uM incubated for 24 hrs by Thioflavin T based fluorometric assay relative to control | |||
| AID1424232 | Antioxidant activity assessed as superoxide anion free radical scavenging activity by measuring rate constant using UV irradiation by ESR spin trapping method | 2017 | European journal of medicinal chemistry, Jun-16, Volume: 133 | Free radicals and polyphenols: The redox chemistry of neurodegenerative diseases. |
| AID1075913 | Antioxidant activity assessed as ROS scavenging activity at 1 to 10 uM by DCFDA assay | 2014 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 24, Issue:5 | MHY884, a newly synthesized tyrosinase inhibitor, suppresses UVB-induced activation of NF-κB signaling pathway through the downregulation of oxidative stress. |
| AID1713223 | Permeability of the compound at pH 7.4 by PAMPA-BBB assay | 2016 | European journal of medicinal chemistry, Nov-10, Volume: 123 | Synthesis and in vitro, ex-vivo and in vivo activity of hybrid compounds linking a potent ROS and RNS scavenger activity with diverse substrates addressed to pass across the blood-brain barrier. |
| AID1306590 | Antioxidant activity assessed as inhibition of DPPH free radical scavenging activity after 60 mins by UV-Visible spectrophotometry | 2016 | Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16 | Synthesis and evaluation of antioxidant phenolic diaryl hydrazones as potent antiangiogenic agents in atherosclerosis. |
| AID75288 | In vitro glutathione peroxidase activity at 2*10e-7M using tert-butyl hydroperoxide, activity given in percentage of ebselen''s activity | 1994 | Journal of medicinal chemistry, Sep-02, Volume: 37, Issue:18 | Benzoselenazolinone derivatives designed to be glutathione peroxidase mimetics feature inhibition of cyclooxygenase/5-lipoxygenase pathways and anti-inflammatory activity. |
| AID497113 | Antioxidant activity against DPPH free radical assessed as compound able to consume half the amount of free radical after 1 hr | 2010 | Bioorganic & medicinal chemistry, Aug-01, Volume: 18, Issue:15 | Synthesis and biological evaluation of arylidene analogues of Meldrum's acid as a new class of antimalarial and antioxidant agents. |
| AID1493969 | Antiproliferative activity against human HeLa cells after 48 hrs by SRB assay | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | A green multicomponent synthesis of tocopherol analogues with antiproliferative activities. |
| AID639374 | Neuroprotective activity against rotenone/oligomycin A-induced cell death in human SH-SY5Y cells assessed as LDH release at 1 uM treated 24 hrs before rotenone/oligomycin A challenge measured after 24 hrs relative to control | 2011 | European journal of medicinal chemistry, Jun, Volume: 46, Issue:6 | N-acylaminophenothiazines: neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease. |
| AID436260 | Antioxidant activity assessed as DPPH radical scavenging activity | 2008 | Journal of natural products, Nov, Volume: 71, Issue:11 | Synthesis and biological activities of thio-avarol derivatives. |
| AID663247 | Neuroprotective activity in human SH-SY5Y cells assessed as protection against H2O2-induced oxidative stress at 10 uM incubated for 1 hr prior to H2O2-challenge measured after 12 hrs by MTT assay | 2012 | Journal of medicinal chemistry, Apr-12, Volume: 55, Issue:7 | Multifunctional mercapto-tacrine derivatives for treatment of age-related neurodegenerative diseases. |
| AID1392723 | Cytoprotection against H2O2-induced oxidative stress in rat PC12 cells assessed as increase in cell viability up to 10 uM after 24 hrs by MTT assay | |||
| AID23927 | The compound was evaluated for lipophilicity | 2001 | Journal of medicinal chemistry, Nov-22, Volume: 44, Issue:24 | Novel potent inhibitors of lipid peroxidation with protective effects against reperfusion arrhythmias. |
| AID1348943 | Antioxidant activity assessed as DPPH radical scavenging activity after 60 mins by spectrophotometric method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Trisubstituted barbiturates and thiobarbiturates: Synthesis and biological evaluation as xanthine oxidase inhibitors, antioxidants, antibacterial and anti-proliferative agents. |
| AID1256114 | Antioxidant activity assessed as ABTS radical scavenging activity after 7 mins | 2015 | Journal of medicinal chemistry, Nov-12, Volume: 58, Issue:21 | Identification of Highly Promising Antioxidants/Neuroprotectants Based on Nucleoside 5'-Phosphorothioate Scaffold. Synthesis, Activity, and Mechanisms of Action. |
| AID1310992 | Antioxidant activity assessed as inhibition of allopurinol-xanthine oxidase system-mediated superoxide formation measured over 7 mins by lucigenin-based chemiluminescence analysis | 2016 | European journal of medicinal chemistry, Aug-25, Volume: 119 | On the vasoprotective mechanisms underlying novel β-phosphorylated nitrones: Focus on free radical characterization, scavenging and NO-donation in a biological model of oxidative stress. |
| AID1141995 | Antioxidant activity assessed as inhibition of Fe3+/ascorbic acid-induced hydroxyl radical formation by measuring DMSO-induced formaldehyde production at 100 uM after 30 mins relative to control | 2014 | European journal of medicinal chemistry, Jun-10, Volume: 80 | Synthesis of stable aromatic and heteroaromatic sulfonyl-amidoximes and evaluation of their antioxidant and lipid peroxidation activity. |
| AID1306599 | Inhibition of oxidized LDL induced intracellular ROS formation in HMEC1 at 10 uM preincubated for 30 to 40 mins followed by H2DCFDA-AM addition by fluorescence analysis | 2016 | Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16 | Synthesis and evaluation of antioxidant phenolic diaryl hydrazones as potent antiangiogenic agents in atherosclerosis. |
| AID1493753 | Antioxidant activity assessed as ABTS radical scavenging activity measured after 12 to 16 hrs | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Design, synthesis and biochemical evaluation of novel multi-target inhibitors as potential anti-Parkinson agents. |
| AID247569 | In vitro inhibitory concentration against hydroxyl radical (-OH) | 2005 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 15, Issue:12 | Nitrone derivatives of trolox as neuroprotective agents. |
| AID1581657 | Antioxidant activity assessed as ABTS radical scavenging activity at 75 uM measured after 60 mins by spectrophotometric assay relative to control | 2020 | European journal of medicinal chemistry, Feb-01, Volume: 187 | 1-Benzylpyrrolidine-3-amine-based BuChE inhibitors with anti-aggregating, antioxidant and metal-chelating properties as multifunctional agents against Alzheimer's disease. |
| AID1300894 | Antioxidant activity assessed as ABTS radical scavenging activity after 30 mins under dark conditions | 2016 | European journal of medicinal chemistry, Jul-19, Volume: 117 | Novel 1,3-thiazolidin-4-one derivatives as promising anti-Candida agents endowed with anti-oxidant and chelating properties. |
| AID16876 | The reaction rate constant (K) by measuring competition with nitroblue tetrazolium of the superoxide radicals formed by xanthine oxidase/xanthine | 1995 | Journal of medicinal chemistry, Jul-21, Volume: 38, Issue:15 | Cardioselective ammonium, phosphonium, and sulfonium analogues of alpha-tocopherol and ascorbic acid that inhibit in vitro and ex vivo lipid peroxidation and scavenge superoxide radicals. |
| AID1581650 | Antioxidant activity assessed as ABTS radical scavenging activity at 30 uM measured after 5 mins by spectrophotometric assay relative to control | 2020 | European journal of medicinal chemistry, Feb-01, Volume: 187 | 1-Benzylpyrrolidine-3-amine-based BuChE inhibitors with anti-aggregating, antioxidant and metal-chelating properties as multifunctional agents against Alzheimer's disease. |
| AID1762401 | Inhibition of porcine liver carboxylesterase using 4-NPA as substrate preincubated for 10 mins followed by substrate addition by spectrophotometric analysis | 2021 | European journal of medicinal chemistry, Jun-05, Volume: 218 | Novel potent bifunctional carboxylesterase inhibitors based on a polyfluoroalkyl-2-imino-1,3-dione scaffold. |
| AID1071846 | Antioxidant activity assessed as rosebengal-induced singlet oxygen radical scavenging activity by ESR spin trapping method relative to 4-OH-TEMP | 2014 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 24, Issue:5 | A multiple free-radical scavenging (MULTIS) study on the antioxidant capacity of a neuroprotective drug, edaravone as compared with uric acid, glutathione, and trolox. |
| AID477898 | Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins | 2010 | Journal of natural products, Apr-23, Volume: 73, Issue:4 | Sesquiterpenoid aminoquinones from the marine sponge Dysidea sp. |
| AID1659474 | Inhibition of AKR1A1 in rat kidney at 10 uM relative to control | 2020 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 30, Issue:9 | Novel quinolin-4(1H)-one derivatives as multi-effective aldose reductase inhibitors for treatment of diabetic complications: Synthesis, biological evaluation, and molecular modeling studies. |
| AID1320857 | Antioxidant activity assessed as DPPH free radical scavenging activity after 60 mins | 2016 | European journal of medicinal chemistry, Oct-04, Volume: 121 | Do cinnamylideneacetophenones have antioxidant properties and a protective effect toward the oxidation of phosphatidylcholines? |
| AID1428456 | Antioxidant activity assessed as DPPH radical scavenging activity incubated for 30 mins | 2016 | Journal of natural products, Dec-23, Volume: 79, Issue:12 | Antioxidant Flavonols and Phenolic Compounds from Atraphaxis frutescens and Their Inhibitory Activities against Insect Phenoloxidase and Mushroom Tyrosinase. |
| AID548347 | Neuroprotective activity against H2O2-induced oxidative stress in human SH-SY5Y cells assessed as LDH release at 3 uM after 24 hrs by UV-vis spectroscopy | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | Old phenothiazine and dibenzothiadiazepine derivatives for tomorrow's neuroprotective therapies against neurodegenerative diseases. |
| AID1647676 | Neuroprotective activity against glutamate-induced cell damage in mouse HT22 assessed as increase cell viability at 1.3 to 15 uM after 24 hrs by luminescent cell viability assay | 2020 | Journal of natural products, 02-28, Volume: 83, Issue:2 | Palhinosides A-H: Flavone Glucosidic Truxinate Esters with Neuroprotective Activities from |
| AID1713222 | Antioxidant activity assessed as DPPH radical scavenging activity incubated for 60 mins in absence of light | 2016 | European journal of medicinal chemistry, Nov-10, Volume: 123 | Synthesis and in vitro, ex-vivo and in vivo activity of hybrid compounds linking a potent ROS and RNS scavenger activity with diverse substrates addressed to pass across the blood-brain barrier. |
| AID1252287 | Inhibition of Fe-dependent reactive oxygen species formation at 10 to 5000 uM after 90 mins by H2DCF-DA-based fluorescence assay | 2015 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 25, Issue:21 | A multifunctional, light-activated prochelator inhibits UVA-induced oxidative stress. |
| AID1892586 | Antioxidant activity assessed as DPPH radical scavenging activity at 5 uM incubated for 30 mins by DPPH assay relative to control | 2022 | Journal of medicinal chemistry, 07-14, Volume: 65, Issue:13 | Novel Hydroxychalcone-Based Dual Inhibitors of Aldose Reductase and α-Glucosidase as Potential Therapeutic Agents against Diabetes Mellitus and Its Complications. |
| AID403309 | DPPH radical scavenging activity assessed as ratio of IC50 for trolox to IC50 for test compound | 2004 | Journal of natural products, Jul, Volume: 67, Issue:7 | New lamellarin alkaloids from the Indian ascidian Didemnum obscurum and their antioxidant properties. |
| AID604212 | Antioxidant activity assessed as inhibition of DPPH free radicals at 1 mM after 30 mins by UV-visible spectrophotometer analysis relative to control | 2011 | Bioorganic & medicinal chemistry, Jul-01, Volume: 19, Issue:13 | Synthesis and evaluation of fluorescent heterocyclic aminoadamantanes as multifunctional neuroprotective agents. |
| AID458692 | Cytotoxicity against human MG63 cells assessed as cell death at 60 uM after 7 days by LDH assay | 2010 | Bioorganic & medicinal chemistry, Mar-01, Volume: 18, Issue:5 | Exploring a synthetic organoselenium compound for antioxidant pharmacotherapy--toxicity and effects on ROS-production. |
| AID1424254 | Antioxidant activity assessed as effect on linolenic acid autooxidation in presence of DLPC liposomes | 2017 | European journal of medicinal chemistry, Jun-16, Volume: 133 | Free radicals and polyphenols: The redox chemistry of neurodegenerative diseases. |
| AID751207 | Antioxidant activity in rat PC12 cells assessed as inhibition of Fe2+-induced ROS production after 1 hr by DCFH-DA staining-based fluorometric analysis | 2013 | Journal of medicinal chemistry, Jun-27, Volume: 56, Issue:12 | Highly efficient biocompatible neuroprotectants with dual activity as antioxidants and P2Y receptor agonists. |
| AID218995 | Oxidation was assessed indirectly by measuring bovine serum albumin(BSA) thiol protection from the formation of thiobarbituric acid reactive substances (TBARs) by TBARs test at 100 uM | 2002 | Bioorganic & medicinal chemistry letters, Jan-21, Volume: 12, Issue:2 | New series of aryloxypropanolamines with both human beta(3)-adrenoceptor agonistic activity and free radical scavenging properties. |
| AID492253 | Antioxidant activity assessed as ABTS radical scavenging activity | 2010 | Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14 | Tryptamine-derived alkaloids from Annonaceae exerting neurotrophin-like properties on primary dopaminergic neurons. |
| AID492248 | Antioxidant activity in mesecephalic neuron assessed as ROS production at 10 uM by dihydrorhodamine-123 incorporation assay relative to control | 2010 | Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14 | Tryptamine-derived alkaloids from Annonaceae exerting neurotrophin-like properties on primary dopaminergic neurons. |
| AID281656 | Hydroxyl radical scavenging activity after 2 hrs by ABTS competition assay | 2004 | Journal of medicinal chemistry, Dec-02, Volume: 47, Issue:25 | Effects of indole fatty alcohols on the differentiation of neural stem cell derived neurospheres. |
| AID195018 | The concentration of compound required to inhibit generation of superoxide by 50 percent in rat liver | 1990 | Journal of medicinal chemistry, May, Volume: 33, Issue:5 | Studies on hindered phenols and analogues. 2. 1,3-Benzoxathioles having SRS-A inhibiting activity. |
| AID1436065 | Neuroprotective activity against H2O2-induced damage in rat PC12 cells assessed as reduction in LDH release at 100 uM pretreated for 2 hrs followed by H2O2 challenge measured after 24 hrs | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | Aurone Mannich base derivatives as promising multifunctional agents with acetylcholinesterase inhibition, anti-β-amyloid aggragation and neuroprotective properties for the treatment of Alzheimer's disease. |
| AID427663 | Antioxidant activity assessed as potassium ferric cyanide ion reducing power after 10 mins by Oyaizu method | 2009 | Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13 | Potential antioxidants and tyrosinase inhibitors from synthetic polyphenolic deoxybenzoins. |
| AID1892578 | Antioxidant activity in rat brain homogenate assessed as inhibition of lipid peroxidation by measuring MDA concentration at 1 uM by TBARS assay relative to control | 2022 | Journal of medicinal chemistry, 07-14, Volume: 65, Issue:13 | Novel Hydroxychalcone-Based Dual Inhibitors of Aldose Reductase and α-Glucosidase as Potential Therapeutic Agents against Diabetes Mellitus and Its Complications. |
| AID1767564 | Antioxidant activity assessed as DPPH radical scavenging activity at 50 uM incubated for 1 hrs under light restrictive condition by UV-microplate reader assay relative to control | 2021 | European journal of medicinal chemistry, Oct-15, Volume: 222 | Synthesis, biological evaluation and molecular modeling of benzofuran piperidine derivatives as Aβ antiaggregant. |
| AID459648 | Cytotoxicity against human SH-SY5Y cells assessed as cell death at 60 uM after 7 days by LDH assay | 2010 | Bioorganic & medicinal chemistry, Mar-01, Volume: 18, Issue:5 | Exploring a synthetic organoselenium compound for antioxidant pharmacotherapy--toxicity and effects on ROS-production. |
| AID1083352 | Antioxidant activity assessed as DPPH radical scavenging activity at 5 X 10'-5 M after 60 min | 2011 | Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, , Volume: 20, Issue:2 | The novel amidocarbamate derivatives of ketoprofen: synthesis and biological activity. |
| AID1592381 | Cytotoxicity against human SH-SY5Y cells assessed as cell metabolic activity at 50 uM incubated for 24 hrs by MTT assay relative to control | |||
| AID181705 | Compound was evaluated for prevention of spontaneous lipid peroxidation in rat brain homogenate. | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1 | A cardioselective, hydrophilic N,N,N-trimethylethanaminium alpha-tocopherol analogue that reduces myocardial infarct size. |
| AID1298962 | Reduction of MDA level in Wistar rat brain at 100 uM after 30 mins in presence of ascorbic acid by UV-vis spectrophotmetry relative to control | 2016 | Bioorganic & medicinal chemistry letters, 06-15, Volume: 26, Issue:12 | Synthesis of benzothiadiazine derivatives exhibiting dual activity as aldose reductase inhibitors and antioxidant agents. |
| AID1729067 | Antioxidant activity assessed as DPPH radical scavenging activity at 10 uM incubated for 30 mins under dark condition relative to control | 2021 | European journal of medicinal chemistry, Mar-05, Volume: 213 | A greener protocol for the synthesis of phosphorochalcogenoates: Antioxidant and free radical scavenging activities. |
| AID462444 | Antioxidant activity assessed as DPPH radical scavenging activity at 0.2 mM | 2010 | Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6 | Design and synthesis of novel series of pyrrole based chemotypes and their evaluation as selective aldose reductase inhibitors. A case of bioisosterism between a carboxylic acid moiety and that of a tetrazole. |
| AID1713235 | Cytotoxicity against human SH-SY5Y cells assessed as cell viability at 25 uM measured after 24 hrs by MTT assay relative to control | 2016 | European journal of medicinal chemistry, Nov-10, Volume: 123 | Synthesis and in vitro, ex-vivo and in vivo activity of hybrid compounds linking a potent ROS and RNS scavenger activity with diverse substrates addressed to pass across the blood-brain barrier. |
| AID1372027 | Antioxidant activity assessed as relative scavenging rate constant for photolysis-induced alkoxyl scavenging activity by measuring Kaox/Kst ratio using DMPO spin trap by ESR spectroscopic method | 2017 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23 | Resveratrol analogues like piceatannol are potent antioxidants as quantitatively demonstrated through the high scavenging ability against reactive oxygen species and methyl radical. |
| AID1248048 | Antioxidant activity assessed as inhibition of AAPH-induced lipid peroxidation at 200 ug/ml after 3 hrs by TBA-MDA test | 2015 | Bioorganic & medicinal chemistry, Oct-01, Volume: 23, Issue:19 | Synthesis, electronic properties, antioxidant and antibacterial activity of some new benzimidazoles. |
| AID1298960 | Antioxidant activity assessed as DPPH free radical scavenging activity at 1 uM after 40 mins by UV-Vis spectrophotometry | 2016 | Bioorganic & medicinal chemistry letters, 06-15, Volume: 26, Issue:12 | Synthesis of benzothiadiazine derivatives exhibiting dual activity as aldose reductase inhibitors and antioxidant agents. |
| AID592727 | Antioxidant activity assessed as inhibition of free radical production at 0.58 mM within 6 mins by ABTS+ decolorization assay | 2011 | Bioorganic & medicinal chemistry, Apr-15, Volume: 19, Issue:8 | In vitro and QSAR studies of cucurbitacins on HepG2 and HSC-T6 liver cell lines. |
| AID548181 | Antioxidant activity assessed as DPPH radical scavenging activity | 2010 | Journal of natural products, Nov-29, Volume: 73, Issue:11 | Benzophenones and biflavonoids from Rheedia edulis. |
| AID240679 | Anti-oxidant activity in DPPH radical scavenging assay; n=3-4 | 2005 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 15, Issue:7 | Design, synthesis, biological evaluation and molecular docking of curcumin analogues as antioxidant, cyclooxygenase inhibitory and anti-inflammatory agents. |
| AID1743179 | Antioxidant activity assessed as AAPH scavenging activity by measuring residual fluorescence at 50 uM measured at 1 min interval for 30 mins by ORAC fluorescein assay relative to control | 2020 | European journal of medicinal chemistry, Dec-15, Volume: 208 | Multiple biological active 4-aminopyrazoles containing trifluoromethyl and their 4-nitroso-precursors: Synthesis and evaluation. |
| AID1357811 | Inhibition of amyloid beta (1 to 42) (unknown origin) self-aggregation after 24 hrs by thioflavin-T fluorescence assay | 2018 | European journal of medicinal chemistry, May-10, Volume: 151 | Novel sarsasapogenin-triazolyl hybrids as potential anti-Alzheimer's agents: Design, synthesis and biological evaluation. |
| AID490943 | Antioxidant activity assessed as DPPH radical scavenging activity at 50 uM after 20 mins | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Synthesis and biological screening of some novel amidocarbamate derivatives of ketoprofen. |
| AID639369 | Neuroprotective activity against H2O2-induced cell death in human SH-SY5Y cells assessed as LDH release at 3 uM incubated for 24 hrs before H2O2 challenge measured after 24 hrs relative to control | 2011 | European journal of medicinal chemistry, Jun, Volume: 46, Issue:6 | N-acylaminophenothiazines: neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease. |
| AID1892589 | Antioxidant activity in rat brain homogenate assessed as inhibition of lipid peroxidation by measuring MDA concentration at 100 uM by TBARS assay relative to control | 2022 | Journal of medicinal chemistry, 07-14, Volume: 65, Issue:13 | Novel Hydroxychalcone-Based Dual Inhibitors of Aldose Reductase and α-Glucosidase as Potential Therapeutic Agents against Diabetes Mellitus and Its Complications. |
| AID1596339 | Antioxidant activity assessed as DPPH free radical scavenging activity at 10 uM after 30 mins incubation in dark by UV-Visible spectrophotometric analysis relative to control | 2019 | European journal of medicinal chemistry, Jul-15, Volume: 174 | Multi-targeted ChEI-copper chelating molecules as neuroprotective agents. |
| AID125798 | Evaluated for the antioxidant property by measuring the inhibition of microsomal lipid peroxidation | 2001 | Bioorganic & medicinal chemistry letters, Jan-22, Volume: 11, Issue:2 | Synthesis and evaluation of caffeic acid amides as antioxidants. |
| AID248540 | Inhibition concentration against lipid peroxidation initiated by [Fe2+] and L-ascorbic acid in rat brain homogenates | 2005 | Bioorganic & medicinal chemistry letters, Jun-02, Volume: 15, Issue:11 | Synthesis and evaluation of 6-hydroxy-7-methoxy-4-chromanone- and chroman-2-carboxamides as antioxidants. |
| AID548959 | Antioxidant activity against AAPH-induced lipid peroxidation assessed as inhibition of conjugated diene hydroperoxide production at 0.1 mM by UV spectrophotometry | 2010 | Bioorganic & medicinal chemistry, Dec-01, Volume: 18, Issue:23 | Does conjugation of antioxidants improve their antioxidative/anti-inflammatory potential? |
| AID683737 | Antioxidant activity against AAPH-induced lipid peroxidation assessed as induction time of inhibition at 0.1 mM | 2012 | Journal of medicinal chemistry, Jan-12, Volume: 55, Issue:1 | Α-aryl-N-alkyl nitrones, as potential agents for stroke treatment: synthesis, theoretical calculations, antioxidant, anti-inflammatory, neuroprotective, and brain-blood barrier permeability properties. |
| AID1320872 | Inhibition of human serum BuChE using butyrylthiocholine as substrate preincubated for 5 mins followed by substrate addition measured for 5 mins by Ellman's method | 2016 | European journal of medicinal chemistry, Oct-04, Volume: 121 | New cinnamic - N-benzylpiperidine and cinnamic - N,N-dibenzyl(N-methyl)amine hybrids as Alzheimer-directed multitarget drugs with antioxidant, cholinergic, neuroprotective and neurogenic properties. |
| AID550004 | Antioxidant activity assessed as ABTS radical scavenging activity by decolorization assay | 2010 | Journal of natural products, Nov-29, Volume: 73, Issue:11 | Terpenoids from the aerial parts of Parasenecio deltophylla. |
| AID567041 | Antioxidant activity assessed as Fe3+/ascorbic acid-induced hydroxyl radical scavenging activity at 0.1 mM | 2011 | European journal of medicinal chemistry, Jan, Volume: 46, Issue:1 | Design, synthesis and pharmacobiological evaluation of novel acrylic acid derivatives acting as lipoxygenase and cyclooxygenase-1 inhibitors with antioxidant and anti-inflammatory activities. |
| AID442507 | Antioxidant activity assessed as inhibition of AAPH-induced lipid peroxidation at 100 uM | 2010 | European journal of medicinal chemistry, Jan, Volume: 45, Issue:1 | Syntheses and evaluation of the antioxidant activity of acitretin analogs with amide bond(s) in the polyene spacer. |
| AID457182 | Antioxidant activity assessed as hydroxyl radical scavenging activity by chemiluminescence assay | 2010 | Bioorganic & medicinal chemistry, Jan-15, Volume: 18, Issue:2 | Quiquelignan A-H, eight new lignoids from the rattan palm Calamus quiquesetinervius and their antiradical, anti-inflammatory and antiplatelet aggregation activities. |
| AID277123 | DPPH radical scavenging activity | 2006 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 16, Issue:24 | Total synthesis and biological evaluation of viscolin, a 1,3-diphenylpropane as a novel potent anti-inflammatory agent. |
| AID1318718 | Antioxidant activity assessed as DPPH free radical scavenging activity at 100 uM after 30 mins by UV-spectrophotometric method relative to control | 2016 | European journal of medicinal chemistry, Oct-04, Volume: 121 | A series of pyrido[2,3-b]pyrazin-3(4H)-one derivatives as aldose reductase inhibitors with antioxidant activity. |
| AID1143751 | Neuroprotective activity in human SH-SY5Y cells assessed as protection against rotenone-oligomycin-induced toxicity at 1 uM co-incubated with rotenone-oligomycin measured after 24 hrs by lactate dehydrogenase release assay | 2014 | European journal of medicinal chemistry, Jun-23, Volume: 81 | Dibenzo[1,4,5]thiadiazepine: a hardly-known heterocyclic system with neuroprotective properties of potential usefulness in the treatment of neurodegenerative diseases. |
| AID1333872 | Antioxidant activity assessed as reduction in AAPH free radical-induced linoleic acid peroxidation activity measured at 100 ug/ml by UV spectroscopic analysis | 2017 | Bioorganic & medicinal chemistry letters, 01-01, Volume: 27, Issue:1 | Synthesis of new morpholine-connected pyrazolidine derivatives and their antimicrobial, antioxidant, and cytotoxic activities. |
| AID406774 | DPPH radical scavenging activity at 100 uM | 2008 | Journal of medicinal chemistry, Jul-10, Volume: 51, Issue:13 | Efficient synthesis and neuroprotective effect of substituted 1,3-diphenyl-2-propen-1-ones. |
| AID1474956 | Antioxidant activity assessed as ABTS radical scavenging activity at 1 mg/ml incubated for 2 hrs in dark by spectrophotometric analysis (Rvb = 1 to 9%) | 2017 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11 | Stereoselective synthesis of enantiopure N-substituted pyrrolidin-2,5-dione derivatives by 1,3-dipolar cycloaddition and assessment of their in vitro antioxidant and antibacterial activities. |
| AID264485 | Viability of rotifers against hydrogen peroxide toxicity at 10 uM | 2006 | Journal of medicinal chemistry, May-04, Volume: 49, Issue:9 | Fluorinated amphiphilic amino acid derivatives as antioxidant carriers: a new class of protective agents. |
| AID228717 | Antioxidant efficiency of compounds was evaluated by the lag phase duration until onset of linoleate peroxidation induced by AAPH | 2003 | Bioorganic & medicinal chemistry letters, Feb-24, Volume: 13, Issue:4 | Protective effect of imidazolopyrazinone antioxidants on ischemia/reperfusion injury. |
| AID490948 | Antioxidant activity assessed as inhibition of lipid peroxidation at 10 uM | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Synthesis and biological screening of some novel amidocarbamate derivatives of ketoprofen. |
| AID1075988 | Neuroprotective activity against H2O2-induced oxidative stress in mouse/rat NG108-15 cells assessed as cell viability at 100 uM incubated for 2 hrs prior to H2O2 challenge for 2 hrs by MTT assay | 2014 | European journal of medicinal chemistry, Mar-21, Volume: 75 | Synthesis, biological evaluation and molecular modeling study of novel tacrine-carbazole hybrids as potential multifunctional agents for the treatment of Alzheimer's disease. |
| AID1543564 | Neuroprotective activity against H2O2-induced oxidative damage in human SH-SY5Y cells assessed as cell viability at 10 uM measured after 24 hrs by MTT assay relative to control | 2019 | European journal of medicinal chemistry, Apr-01, Volume: 167 | Synthesis and evaluation of novel GSK-3β inhibitors as multifunctional agents against Alzheimer's disease. |
| AID1306595 | Cytoprotective activity in HMEC1 assessed as inhibition of oxidized LDL induced toxicity measured as residual viability at 1 uM after 24 hrs by MTT assay (Rvb = 20 +/- 5 %) | 2016 | Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16 | Synthesis and evaluation of antioxidant phenolic diaryl hydrazones as potent antiangiogenic agents in atherosclerosis. |
| AID196391 | Compound was evaluated for its inhibitory concentration against [Fe2+]/AA- induced oxidative neuronal damage in primary cultured rat cortical cells | 2002 | Bioorganic & medicinal chemistry letters, Sep-16, Volume: 12, Issue:18 | Synthesis and evaluation of 4-hydroxyphenylacetic acid amides and 4-hydroxycinnamamides as antioxidants. |
| AID419627 | Antioxidant activity in 2',7'-dichlorodihydrofluorescein diacetate-treated human MCF7 cells assessed as reduction of H2O2 production at 100 uM during after 24 hrs by FACS analysis | 2009 | European journal of medicinal chemistry, Jun, Volume: 44, Issue:6 | Synthesis and antioxidant potential of novel synthetic benzophenone analogues. |
| AID1071843 | Antioxidant activity assessed as AAPH-induced alkoxyl radical scavenging activity by ESR spin trapping method | 2014 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 24, Issue:5 | A multiple free-radical scavenging (MULTIS) study on the antioxidant capacity of a neuroprotective drug, edaravone as compared with uric acid, glutathione, and trolox. |
| AID1083349 | Inhibition of Glycine max (soybean) lipoxygenase using sodium linoleate as substrate at 1 X 10'-4 | 2011 | Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, , Volume: 20, Issue:2 | The novel amidocarbamate derivatives of ketoprofen: synthesis and biological activity. |
| AID1406257 | Antioxidant activity assessed as DPPH free radical scavenging activity after 90 mins dark incubation | 2018 | European journal of medicinal chemistry, Aug-05, Volume: 156 | Multi-target-directed ligands for treating Alzheimer's disease: Butyrylcholinesterase inhibitors displaying antioxidant and neuroprotective activities. |
| AID1372032 | Antioxidant activity assessed as rate constant for photolysis-induced methyl radical scavenging activity using DMPO spin trap by ESR spectroscopic method | 2017 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23 | Resveratrol analogues like piceatannol are potent antioxidants as quantitatively demonstrated through the high scavenging ability against reactive oxygen species and methyl radical. |
| AID1610481 | Inhibition of human erythrocyte AChE at 20 uM using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition by Ellman's method relative to control | 2019 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 29, Issue:23 | Synthesis of 2-arylhydrazinylidene-3-oxo-4,4,4-trifluorobutanoic acids as new selective carboxylesterase inhibitors and radical scavengers. |
| AID1179727 | Antioxidant activity assessed as DPPH radical scavenging activity by UV-Visible spectrophotometry | 2014 | Bioorganic & medicinal chemistry, Aug-01, Volume: 22, Issue:15 | Synthesis, antioxidant and cytoprotective evaluation of potential antiatherogenic phenolic hydrazones. A structure-activity relationship insight. |
| AID1228329 | Antioxidant activity assessed as inhibition of AAPH-induced crocin oxidation in hydrophilic medium at 5 to 500 uM by crocin bleaching assay | 2015 | Journal of natural products, May-22, Volume: 78, Issue:5 | Interaction of α-Hexylcinnamaldehyde with a Biomembrane Model: A Possible MDR Reversal Mechanism. |
| AID1603220 | Antioxidant activity assessed as DPPH radical scavenging activity at 1 uM relative to control | 2019 | Bioorganic & medicinal chemistry, 04-15, Volume: 27, Issue:8 | Designing of acyl sulphonamide based quinoxalinones as multifunctional aldose reductase inhibitors. |
| AID1624742 | Antioxidant activity assessed as hydroxyl radical scavenging activity at 0.1 mM measured after 30 mins | 2019 | Journal of medicinal chemistry, 02-28, Volume: 62, Issue:4 | New Quinolylnitrones for Stroke Therapy: Antioxidant and Neuroprotective ( Z)- N- tert-Butyl-1-(2-chloro-6-methoxyquinolin-3-yl)methanimine Oxide as a New Lead-Compound for Ischemic Stroke Treatment. |
| AID639456 | Neuroprotective activity against rotenone/oligomycin A-induced cell death in human SH-SY5Y cells assessed as LDH release at 3 uM treated 24 hrs before rotenone/oligomycin A challenge measured after 24 hrs relative to control | 2011 | European journal of medicinal chemistry, Jun, Volume: 46, Issue:6 | N-acylaminophenothiazines: neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease. |
| AID1437794 | Antioxidant activity of the compound assessed as DPPH radical scavenging activity after 30 mins | 2017 | European journal of medicinal chemistry, Feb-15, Volume: 127 | Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer's disease. |
| AID1713238 | Cytotoxicity against human SH-SY5Y cells assessed as cell viability at 3.1 uM measured after 24 hrs by MTT assay relative to control | 2016 | European journal of medicinal chemistry, Nov-10, Volume: 123 | Synthesis and in vitro, ex-vivo and in vivo activity of hybrid compounds linking a potent ROS and RNS scavenger activity with diverse substrates addressed to pass across the blood-brain barrier. |
| AID469935 | Antioxidant activity assessed as DPPH radical scavenging activity | 2009 | Journal of natural products, Aug, Volume: 72, Issue:8 | Constituents of the leaves of Magnolia ovata. |
| AID459651 | Cytotoxicity against human MG63 cells assessed as plasma membrane damage at 60 uM after 7 days by LDH assay | 2010 | Bioorganic & medicinal chemistry, Mar-01, Volume: 18, Issue:5 | Exploring a synthetic organoselenium compound for antioxidant pharmacotherapy--toxicity and effects on ROS-production. |
| AID1326568 | Antioxidant activity in Salmonella typhimurium TA102 harboring hysG428 mutant assessed as inhibition of t-BuO2H-dependant mutant formation at 30 uM preincubated with compound followed by t-BuO2H addition after 48 hrs by Ames test | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Antioxidant and antitumor activity of trolox, trolox succinate, and α-tocopheryl succinate conjugates with nitroxides. |
| AID401039 | Antioxidant activity assessed as DPPH radical scavenging activity | 1998 | Journal of natural products, May, Volume: 61, Issue:5 | Isolation, identification, and antioxidant activity of three stilbene glucosides newly extracted from vitis vinifera cell cultures |
| AID1713226 | Cytotoxicity against human SH-SY5Y cells assessed as cell viability at 50 uM measured after 2 hrs by MTT assay relative to control | 2016 | European journal of medicinal chemistry, Nov-10, Volume: 123 | Synthesis and in vitro, ex-vivo and in vivo activity of hybrid compounds linking a potent ROS and RNS scavenger activity with diverse substrates addressed to pass across the blood-brain barrier. |
| AID1326582 | Cytotoxicity against mouse LMTK cells assessed as reduction in cell viability at 300 uM after 72 hrs by MTT assay | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Antioxidant and antitumor activity of trolox, trolox succinate, and α-tocopheryl succinate conjugates with nitroxides. |
| AID1435201 | Antioxidant activity assessed as DPPH radical scavenging activity incubated for 15 mins under dark condition | 2017 | Bioorganic & medicinal chemistry, 03-01, Volume: 25, Issue:5 | New insights into highly potent tyrosinase inhibitors based on 3-heteroarylcoumarins: Anti-melanogenesis and antioxidant activities, and computational molecular modeling studies. |
| AID551409 | Antioxidant activity assessed as hydroxyl radical scavenging activity at 50 uM after 2 hrs by benzoic acid method | 2011 | Bioorganic & medicinal chemistry, Jan-15, Volume: 19, Issue:2 | Synthesis, structure, theoretical and experimental in vitro antioxidant/pharmacological properties of α-aryl, N-alkyl nitrones, as potential agents for the treatment of cerebral ischemia. |
| AID635123 | Inhibition of mushroom tyrosinase activity using L-tyrosin as substrate after 20 mins | 2011 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 21, Issue:24 | Inhibitory activity of novel kojic acid derivative containing trolox moiety on melanogenesis. |
| AID1581658 | Antioxidant activity assessed as ABTS radical scavenging activity at 150 uM measured after 60 mins by spectrophotometric assay relative to control | 2020 | European journal of medicinal chemistry, Feb-01, Volume: 187 | 1-Benzylpyrrolidine-3-amine-based BuChE inhibitors with anti-aggregating, antioxidant and metal-chelating properties as multifunctional agents against Alzheimer's disease. |
| AID197084 | Inhibition of in vitro peroxidation (LP) of rat Hepatic microsomal membrane lipid | 2001 | Journal of medicinal chemistry, Nov-22, Volume: 44, Issue:24 | Novel potent inhibitors of lipid peroxidation with protective effects against reperfusion arrhythmias. |
| AID452854 | Antioxidant activity assessed as inhibition of AAPH-induced lipid peroxidation at 10 uM by uV spectrophotometry | 2009 | Bioorganic & medicinal chemistry, Dec-01, Volume: 17, Issue:23 | Natural and synthetic 2'-hydroxy-chalcones and aurones: synthesis, characterization and evaluation of the antioxidant and soybean lipoxygenase inhibitory activity. |
| AID426426 | Inhibition of soybean lipoxygenase assessed as conversion of sodium linoleate to 13-hydroperoxylinoleic acid at 0.1 mM | 2009 | European journal of medicinal chemistry, Jul, Volume: 44, Issue:7 | Synthesis and evaluation of the antioxidant and anti-inflammatory activity of novel coumarin-3-aminoamides and their alpha-lipoic acid adducts. |
| AID1310990 | Antioxidant activity assessed as DPPH scavenging activity measured after 3 mins by spectrophotometric method | 2016 | European journal of medicinal chemistry, Aug-25, Volume: 119 | On the vasoprotective mechanisms underlying novel β-phosphorylated nitrones: Focus on free radical characterization, scavenging and NO-donation in a biological model of oxidative stress. |
| AID1381602 | Antioxidant activity assessed as DPPH radical scavenging activity at 50 uM after 30 mins dark incubation | 2018 | European journal of medicinal chemistry, Feb-25, Volume: 146 | Design, synthesis, mechanistic and histopathological studies of small-molecules of novel indole-2-carboxamides and pyrazino[1,2-a]indol-1(2H)-ones as potential anticancer agents effecting the reactive oxygen species production. |
| AID619936 | Antioxidant activity assessed as inhibition of linoleic acid lipid peroxidation at 100 ug/ml measured after 36 hrs by ferric thiocynate method | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9 | Isoeugenol-based novel potent antioxidants: synthesis and reactivity. |
| AID1311931 | Neuroprotective activity against H2O2-induced damage in rat PC12 cells assessed as cell viability at 10 uM preincubated for 2 hrs followed by H2O2 addition for 24 hrs by MTT assay | 2016 | Bioorganic & medicinal chemistry, 09-15, Volume: 24, Issue:18 | Synthesis and evaluation of multi-target-directed ligands for the treatment of Alzheimer's disease based on the fusion of donepezil and melatonin. |
| AID1323133 | Antioxidant activity assessed as DPPH free radical scavenging activity at 5 uM after 15 to 60 mins in presence of CuSO4.5H2O | 2016 | Journal of natural products, 07-22, Volume: 79, Issue:7 | Effects of Functional Groups and Sugar Composition of Quercetin Derivatives on Their Radical Scavenging Properties. |
| AID1474958 | Antioxidant activity assessed as ABTS radical scavenging activity at 2.5 mg/ml incubated for 2 hrs in dark by spectrophotometric analysis (Rvb = 1 to 9%) | 2017 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11 | Stereoselective synthesis of enantiopure N-substituted pyrrolidin-2,5-dione derivatives by 1,3-dipolar cycloaddition and assessment of their in vitro antioxidant and antibacterial activities. |
| AID1228617 | Antioxidant activity assessed as hydroxy radical-scavenging activity | 2015 | Journal of natural products, May-22, Volume: 78, Issue:5 | Anti-inflammatory Hydrolyzable Tannins from Myricaria bracteata. |
| AID1264042 | Neuroprotective activity against Fenton reagent-induced hydroxy radical-stimulated cytotoxicity in human ARPE19 cells assessed as cell survival at 1 to 1000 uM preincubated for 1 hr followed by Fenton reagent challenge for 2 hrs by fluorescence-based LIVE | 2015 | Journal of medicinal chemistry, Nov-25, Volume: 58, Issue:22 | Orally Bioavailable Metal Chelators and Radical Scavengers: Multifunctional Antioxidants for the Coadjutant Treatment of Neurodegenerative Diseases. |
| AID450086 | Antioxidant activity assessed as ABTS radical scavenging activity | 2009 | Bioorganic & medicinal chemistry, Sep-15, Volume: 17, Issue:18 | Antioxidant activity of 5,10-dihydroindeno[1,2-b]indoles containing substituents on dihydroindeno part. |
| AID1603218 | Antioxidant activity assessed as DPPH radical scavenging activity at 10 uM relative to control | 2019 | Bioorganic & medicinal chemistry, 04-15, Volume: 27, Issue:8 | Designing of acyl sulphonamide based quinoxalinones as multifunctional aldose reductase inhibitors. |
| AID548346 | Neuroprotective activity against H2O2-induced oxidative stress in human SH-SY5Y cells assessed as LDH release at 1 uM after 24 hrs by UV-vis spectroscopy | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | Old phenothiazine and dibenzothiadiazepine derivatives for tomorrow's neuroprotective therapies against neurodegenerative diseases. |
| AID1678472 | Antioxidant activity in pH 4.5 phosphate buffer assessed as PTIO radical scavenging activity after 1 hr by microplate reader based assay | 2020 | ACS medicinal chemistry letters, Nov-12, Volume: 11, Issue:11 | Covalent Bridging of Corilagin Improves Antiferroptosis Activity: Comparison with 1,3,6-Tri- |
| AID356014 | Antioxidant activity assessed as inhibition of AAPH-induced hemolysis in rat RBC after 3 hrs | 2003 | Journal of natural products, Jun, Volume: 66, Issue:6 | Antioxidative glycosides from the leaves of Ligustrum robustum. |
| AID1264035 | Cytotoxicity against human ARPE19 cells assessed as reduction in cell viability at 1 mM after 2 hrs by MTS assay | 2015 | Journal of medicinal chemistry, Nov-25, Volume: 58, Issue:22 | Orally Bioavailable Metal Chelators and Radical Scavengers: Multifunctional Antioxidants for the Coadjutant Treatment of Neurodegenerative Diseases. |
| AID1348939 | Inhibition of xanthine oxidase (unknown origin) using xanthine as substrate preincubated for 5 mins followed by substrate addition measured every min for 10 mins by spectrophotometric method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Trisubstituted barbiturates and thiobarbiturates: Synthesis and biological evaluation as xanthine oxidase inhibitors, antioxidants, antibacterial and anti-proliferative agents. |
| AID1143752 | Neuroprotective activity in human SH-SY5Y cells assessed as protection against rotenone-oligomycin-induced toxicity at 3 uM co-incubated with rotenone-oligomycin measured after 24 hrs by lactate dehydrogenase release assay | 2014 | European journal of medicinal chemistry, Jun-23, Volume: 81 | Dibenzo[1,4,5]thiadiazepine: a hardly-known heterocyclic system with neuroprotective properties of potential usefulness in the treatment of neurodegenerative diseases. |
| AID1300892 | Antioxidant activity of the compound after 30 mins by CUPRAC method | 2016 | European journal of medicinal chemistry, Jul-19, Volume: 117 | Novel 1,3-thiazolidin-4-one derivatives as promising anti-Candida agents endowed with anti-oxidant and chelating properties. |
| AID1892587 | Antioxidant activity assessed as DPPH radical scavenging activity at 1 uM incubated for 30 mins by DPPH assay relative to control | 2022 | Journal of medicinal chemistry, 07-14, Volume: 65, Issue:13 | Novel Hydroxychalcone-Based Dual Inhibitors of Aldose Reductase and α-Glucosidase as Potential Therapeutic Agents against Diabetes Mellitus and Its Complications. |
| AID536051 | Antioxidant activity assessed as protection against Fenton oxidation-induced thymidine degradation in 11.4 mM phosphate buffer at 100 uM by competitive immuno-enzymatic assay | 2010 | Bioorganic & medicinal chemistry, Nov-15, Volume: 18, Issue:22 | Synthesis and antioxidant properties of pulvinic acids analogues. |
| AID1721452 | Antioxidant activity assessed as DPPH radical scavenging activity incubated for 1 hr under dark condition | 2020 | Journal of medicinal chemistry, 09-10, Volume: 63, Issue:17 | Centrally Active Multitarget Anti-Alzheimer Agents Derived from the Antioxidant Lead CR-6. |
| AID34986 | In vitro inhibitory activity against aldose reductase of rat lens at 10E-5 M concentration | 2003 | Journal of medicinal chemistry, Jan-30, Volume: 46, Issue:3 | Substituted pyrrol-1-ylacetic acids that combine aldose reductase enzyme inhibitory activity and ability to prevent the nonenzymatic irreversible modification of proteins from monosaccharides. |
| AID549274 | Antioxidant activity in mouse BNL-CL2 cells assessed as inhibition of H2O2-induced ROS production at 20 ug/ml by DCFHDA assay | 2010 | Journal of natural products, Nov-29, Volume: 73, Issue:11 | Inhibition of melanogenesis and oxidation by protocatechuic acid from Origanum vulgare (oregano). |
| AID1152636 | Antioxidant activity assessed as hydroxyl radical scavenging activity at 5 uM after 1 hr by 2-Deoxy-D-ribose degradation assay in presence of FeCl3 and EDTA | 2014 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 24, Issue:12 | Synthesis and radical scavenging activity of phenol-imidazole conjugates. |
| AID497109 | Antioxidant activity assessed as DPPH free radical scavenging activity at 100 uM after 1 hr | 2010 | Bioorganic & medicinal chemistry, Aug-01, Volume: 18, Issue:15 | Synthesis and biological evaluation of arylidene analogues of Meldrum's acid as a new class of antimalarial and antioxidant agents. |
| AID619931 | Antioxidant activity assessed as inhibition of linoleic acid lipid peroxidation at 100 ug/ml measured after 6 hrs by ferric thiocynate method | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9 | Isoeugenol-based novel potent antioxidants: synthesis and reactivity. |
| AID1610479 | Inhibition of porcine liver carboxylesterase using 4-NPA as substrate preincubated for 10 mins followed by substrate addition by spectrophotometric analysis | 2019 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 29, Issue:23 | Synthesis of 2-arylhydrazinylidene-3-oxo-4,4,4-trifluorobutanoic acids as new selective carboxylesterase inhibitors and radical scavengers. |
| AID286753 | Antioxidant activity assessed as DPPH reducing activity at 0.1 mM after 20 mins | 2007 | Journal of medicinal chemistry, May-17, Volume: 50, Issue:10 | Design and synthesis of novel quinolinone-3-aminoamides and their alpha-lipoic acid adducts as antioxidant and anti-inflammatory agents. |
| AID344046 | Antioxidant activity assessed as superoxide radical anion scavenging activity after 8 mins | 2008 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 18, Issue:14 | Cyathuscavins A, B, and C, new free radical scavengers with DNA protection activity from the Basidiomycete Cyathus stercoreus. |
| AID1480871 | Neuroprotective activity against glutamate-induced neuronal cell death in mouse HT22 cells assessed as intracellular reactive oxygen species level at 100 uM pretreated for 30 mins followed by glutamate challenge after 10 hrs by DCFH-DA probe based FACS an | 2017 | European journal of medicinal chemistry, Apr-21, Volume: 130 | Design, synthesis and evaluation of 2-arylethenyl-N-methylquinolinium derivatives as effective multifunctional agents for Alzheimer's disease treatment. |
| AID567040 | Antioxidant activity assessed as Fe3+/ascorbic acid-induced hydroxyl radical scavenging activity at 0.01 mM | 2011 | European journal of medicinal chemistry, Jan, Volume: 46, Issue:1 | Design, synthesis and pharmacobiological evaluation of novel acrylic acid derivatives acting as lipoxygenase and cyclooxygenase-1 inhibitors with antioxidant and anti-inflammatory activities. |
| AID1143540 | Antioxidant activity assessed as DPPH radical scavenging activity by spectrophotometric analysis | 2014 | European journal of medicinal chemistry, Jun-23, Volume: 81 | Thiaflavan scavenges radicals and inhibits DNA oxidation: a story from the ferrocene modification. |
| AID663248 | Neuroprotective activity in human SH-SY5Y cells assessed as protection against H2O2-induced oxidative stress at 30 uM incubated for 1 hr prior to H2O2-challenge measured after 12 hrs by MTT assay | 2012 | Journal of medicinal chemistry, Apr-12, Volume: 55, Issue:7 | Multifunctional mercapto-tacrine derivatives for treatment of age-related neurodegenerative diseases. |
| AID1126662 | Antioxidant activity assessed as DPPH radical scavenging activity by spectrophotometry | 2014 | European journal of medicinal chemistry, May-06, Volume: 78 | One-pot synthesis and radical scavenging activity of novel polyhydroxylated 3-arylcoumarins. |
| AID1256878 | Selectivity ratio of IC50 for human plasmatic BChE to IC50 for human recombinant AChE | 2015 | Journal of medicinal chemistry, Nov-25, Volume: 58, Issue:22 | Tacrine-Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity. |
| AID1534716 | Antioxidant activity assessed as ferric ion reduction by measuring trolox equivalents after 3 to 5 mins by FRAP assay | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Synthesis and evaluation of isoprenylation-resveratrol dimer derivatives against Alzheimer's disease. |
| AID1264038 | Neuroprotective activity against Fenton reagent-induced ROS generation in human SH-SY5Y cells assessed as increase in GSH level at 1 mM after 2 hrs by DTNB method | 2015 | Journal of medicinal chemistry, Nov-25, Volume: 58, Issue:22 | Orally Bioavailable Metal Chelators and Radical Scavengers: Multifunctional Antioxidants for the Coadjutant Treatment of Neurodegenerative Diseases. |
| AID1678101 | Antioxidant activity assessed as DPPH radical scavenging activity at 5 uM relative to control | 2020 | Bioorganic & medicinal chemistry, 10-15, Volume: 28, Issue:20 | Dihydrobenzoxazinone derivatives as aldose reductase inhibitors with antioxidant activity. |
| AID471315 | Antioxidant activity assessed as ABTS radical scavenging activity | 2009 | European journal of medicinal chemistry, Dec, Volume: 44, Issue:12 | Captopril and 6-mercaptopurine: whose SH possesses higher antioxidant ability? |
| AID1326573 | Cytotoxicity against human U937 cells assessed as reduction in cell viability after 72 hrs by MTT assay | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Antioxidant and antitumor activity of trolox, trolox succinate, and α-tocopheryl succinate conjugates with nitroxides. |
| AID489923 | Antioxidant activity assessed as inhibition of AAPH-induced lipid peroxidation at 100 uM by UV spectrophotometry | 2010 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 20, Issue:13 | A novel synthesis of 3-aryl coumarins and evaluation of their antioxidant and lipoxygenase inhibitory activity. |
| AID235285 | Free radical scavenging assessed as DPPH color reduction | 2003 | Bioorganic & medicinal chemistry letters, Aug-18, Volume: 13, Issue:16 | Novel 3-O-acyl mesquitol analogues as free-radical scavengers and enzyme inhibitors: synthesis, biological evaluation and structure-activity relationship. |
| AID1382194 | Antioxidant activity assessed as ferric ion reduction by measuring FeSO4 equivalents reducing Fe3+-TPTZ to Fe2+-TPTZ measured every 15 secs for 4 mins by FRAP assay | 2018 | European journal of medicinal chemistry, Feb-25, Volume: 146 | Regioselective synthesis of 7-O-esters of the flavonolignan silibinin and SARs lead to compounds with overadditive neuroprotective effects. |
| AID277126 | Cytotoxicity against microglial cells at 25 uM | 2006 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 16, Issue:24 | Total synthesis and biological evaluation of viscolin, a 1,3-diphenylpropane as a novel potent anti-inflammatory agent. |
| AID1424236 | Antioxidant activity assessed as peroxyl radical scavenging activity by measuring rate constants for hydrogen atom transfer from substituted phenols to polystyrene peroxyl radicals | 2017 | European journal of medicinal chemistry, Jun-16, Volume: 133 | Free radicals and polyphenols: The redox chemistry of neurodegenerative diseases. |
| AID427661 | Antioxidant activity assessed as inhibition of FeCl2-induced lipid peroxidation by thiocyanate method | 2009 | Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13 | Potential antioxidants and tyrosinase inhibitors from synthetic polyphenolic deoxybenzoins. |
| AID759441 | Antioxidant activity in human SH-SY5Y cells assessed as decrease in t-BuOOH-induced intracellular ROS production at 5 to 20 uM incubated for 24 hrs prior to t-BuOOH challenge measured after 30 mins by DCFHDA-based fluorescence assay | 2013 | Journal of medicinal chemistry, Jul-25, Volume: 56, Issue:14 | Design, synthesis, and evaluation of multitarget-directed resveratrol derivatives for the treatment of Alzheimer's disease. |
| AID1628628 | Cytoprotection against AAPH-induced haemolysis in human erythrocytes at 0.01 to 1 mg/l pre-incubated for 20 mins before 60 mM AAPH addition for 4 hrs by spectrophotometric analysis | 2016 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 26, Issue:16 | Antioxidant properties of thio-caffeine derivatives: Identification of the newly synthesized 8-[(pyrrolidin-1-ylcarbonothioyl)sulfanyl]caffeine as antioxidant and highly potent cytoprotective agent. |
| AID1083335 | Antiviral activity against Mammalian orthoreovirus 1 infected VERO cells assessed as inhibition of virus-induced cytopathicity | 2011 | Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, , Volume: 20, Issue:2 | The novel amidocarbamate derivatives of ketoprofen: synthesis and biological activity. |
| AID1399480 | Inhibition of human erythrocyte AChE using acetylthiocholine iodide as substrate incubated for 10 mins followed by substrate addition by Ellman's method | 2018 | Bioorganic & medicinal chemistry, 09-01, Volume: 26, Issue:16 | Synthesis, molecular docking, and biological activity of 2-vinyl chromones: Toward selective butyrylcholinesterase inhibitors for potential Alzheimer's disease therapeutics. |
| AID344044 | Antioxidant activity assessed as DPPH radical scavenging activity after 10 mins | 2008 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 18, Issue:14 | Cyathuscavins A, B, and C, new free radical scavengers with DNA protection activity from the Basidiomycete Cyathus stercoreus. |
| AID567050 | Antioxidant activity assessed as reduction of ABTS radical at 0.1 mM | 2011 | European journal of medicinal chemistry, Jan, Volume: 46, Issue:1 | Design, synthesis and pharmacobiological evaluation of novel acrylic acid derivatives acting as lipoxygenase and cyclooxygenase-1 inhibitors with antioxidant and anti-inflammatory activities. |
| AID594793 | Antioxidant activity in rat liver homogenates assessed as inhibition of lipid peroxidation by measuring formation of thiobarbituric acid-reactive substance after 30 mins | 2011 | Bioorganic & medicinal chemistry letters, May-15, Volume: 21, Issue:10 | Synthesis of cinnamoyl ketoamides as hybrid structures of antioxidants and calpain inhibitors. |
| AID1713224 | Antioxidant activity in human SH-SY5Y cells assessed as inhibition of H2O2-induced DCFH oxidation measured after 1 hr by DCFH-DA dye based fluorescence assay | 2016 | European journal of medicinal chemistry, Nov-10, Volume: 123 | Synthesis and in vitro, ex-vivo and in vivo activity of hybrid compounds linking a potent ROS and RNS scavenger activity with diverse substrates addressed to pass across the blood-brain barrier. |
| AID197085 | The compound was evaluated for the interaction with 0.2 mM of the stable free radical DPPH | 2001 | Journal of medicinal chemistry, Nov-22, Volume: 44, Issue:24 | Novel potent inhibitors of lipid peroxidation with protective effects against reperfusion arrhythmias. |
| AID1330214 | Aqueous solubility of the compound in sodium phosphate buffer at pH 6.8 after 24 hrs by shake flask method | 2016 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 26, Issue:23 | Synthesis and biological assessment of novel N-(hydroxy/methoxy)alkyl β-enaminone curcuminoids. |
| AID1194492 | Antioxidant activity assessed as DPPH radical scavenging activity incubated for 30 mins by UV absorption spectrometry | 2015 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 25, Issue:8 | New septanoside and 20-hydroxyecdysone septanoside derivative from Atriplex portulacoides roots with preliminary biological activities. |
| AID378808 | Antioxidant activity assessed as inhibition of total reactive oxygen species generation in Wistar rat kidney by 2',7'-dichlorofluorescein based fluorescence spectroscopy | 2006 | Journal of natural products, Oct, Volume: 69, Issue:10 | Antioxidative phenolics from the fresh leaves of Ternstroemia japonica. |
| AID635125 | Depigmentation activity in mouse Melan-a cells assessed as inhibition of melanin formation after 4 days | 2011 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 21, Issue:24 | Inhibitory activity of novel kojic acid derivative containing trolox moiety on melanogenesis. |
| AID774815 | Antioxidant activity assessed as ferric ion reducing activity using ferric-TPTZ by measuring concentration of compound with antioxidant capacity equivalent to ferrous sulfate at 0.5 mmol/L by FRAP assay | 2013 | Bioorganic & medicinal chemistry, Nov-01, Volume: 21, Issue:21 | Synthesis and antioxidant activity of novel Mannich base of 1,3,4-oxadiazole derivatives possessing 1,4-benzodioxan. |
| AID277124 | Cytotoxicity against microglial cells at 5 uM | 2006 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 16, Issue:24 | Total synthesis and biological evaluation of viscolin, a 1,3-diphenylpropane as a novel potent anti-inflammatory agent. |
| AID537164 | Antioxidant activity in L-alpha-phosphatidylcholine dioleoyl liposome assessed as inhibition of AAPH-induced lipid peroxidation by LOOH assay | 2010 | Journal of medicinal chemistry, Nov-11, Volume: 53, Issue:21 | A diverse series of substituted benzenesulfonamides as aldose reductase inhibitors with antioxidant activity: design, synthesis, and in vitro activity. |
| AID604214 | Antioxidant activity assessed as inhibition of ABTS free radicals at 0.1 mM after 30 mins by UV-visible spectrophotometer analysis relative to control | 2011 | Bioorganic & medicinal chemistry, Jul-01, Volume: 19, Issue:13 | Synthesis and evaluation of fluorescent heterocyclic aminoadamantanes as multifunctional neuroprotective agents. |
| AID344830 | Antioxidant activity assessed as DPPH radical scavenging activity at 50 uM | 2008 | Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22 | New diterpenoids and the bioactivity of Erythrophleum fordii. |
| AID1381603 | Antioxidant activity assessed as DPPH radical scavenging activity at 10 uM after 30 mins dark incubation | 2018 | European journal of medicinal chemistry, Feb-25, Volume: 146 | Design, synthesis, mechanistic and histopathological studies of small-molecules of novel indole-2-carboxamides and pyrazino[1,2-a]indol-1(2H)-ones as potential anticancer agents effecting the reactive oxygen species production. |
| AID426422 | Antioxidant activity against hydroxyl radical assessed as inhibition of formaldehyde production at 0.1 mM after 30 mins relative to DMSO | 2009 | European journal of medicinal chemistry, Jul, Volume: 44, Issue:7 | Synthesis and evaluation of the antioxidant and anti-inflammatory activity of novel coumarin-3-aminoamides and their alpha-lipoic acid adducts. |
| AID1155646 | Antioxidant activity assessed as reduction of TPTZ-Fe3+ to TPTZ-Fe2+ at 0.15 to 1.5 mM after 5 mins by FRAP assay | 2014 | Journal of natural products, Jun-27, Volume: 77, Issue:6 | Lignans from the fruit of Schisandra glaucescens with antioxidant and neuroprotective properties. |
| AID1402940 | Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability at 30 uM after 18 hrs by MTT assay | 2018 | European journal of medicinal chemistry, Jan-20, Volume: 144 | Synthesis and biological evaluation of diarylheptanoids as potential antioxidant and anti-inflammatory agents. |
| AID1892581 | Antioxidant activity assessed as DPPH radical scavenging activity at 100 uM incubated for 30 mins by DPPH assay relative to control | 2022 | Journal of medicinal chemistry, 07-14, Volume: 65, Issue:13 | Novel Hydroxychalcone-Based Dual Inhibitors of Aldose Reductase and α-Glucosidase as Potential Therapeutic Agents against Diabetes Mellitus and Its Complications. |
| AID619935 | Antioxidant activity assessed as inhibition of linoleic acid lipid peroxidation at 100 ug/ml measured after 30 hrs by ferric thiocynate method | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9 | Isoeugenol-based novel potent antioxidants: synthesis and reactivity. |
| AID1563226 | Antioxidant activity in pH 7.4 phosphate buffer assessed as DPPH radical scavenging activity after 30 mins by spectrophotometric analysis | 2019 | Journal of medicinal chemistry, 07-11, Volume: 62, Issue:13 | Synthesis and Biological Assessment of Pyrrolobenzoxazine Scaffold as a Potent Antioxidant. |
| AID683736 | Antioxidant activity assessed as inhibition of AAPH-induced lipid peroxidation at 0.1 mM by UV spectrophotometric analysis | 2012 | Journal of medicinal chemistry, Jan-12, Volume: 55, Issue:1 | Α-aryl-N-alkyl nitrones, as potential agents for stroke treatment: synthesis, theoretical calculations, antioxidant, anti-inflammatory, neuroprotective, and brain-blood barrier permeability properties. |
| AID406773 | DPPH radical scavenging activity at 50 uM | 2008 | Journal of medicinal chemistry, Jul-10, Volume: 51, Issue:13 | Efficient synthesis and neuroprotective effect of substituted 1,3-diphenyl-2-propen-1-ones. |
| AID731498 | Antioxidant activity assessed as inhibition of xanthine-xanthine oxidase generated superoxide anion radical production by NBT reduction assay | 2013 | Journal of natural products, Jan-25, Volume: 76, Issue:1 | Neolignanamides, lignanamides, and other phenolic compounds from the root bark of Lycium chinense. |
| AID203497 | Formation of DNPH-reactive carbonyl groups in bovine serum albumin exposed to fructose; p<0.001 | 2003 | Journal of medicinal chemistry, Jan-30, Volume: 46, Issue:3 | Substituted pyrrol-1-ylacetic acids that combine aldose reductase enzyme inhibitory activity and ability to prevent the nonenzymatic irreversible modification of proteins from monosaccharides. |
| AID203469 | In vitro ability to inhibit the irreversible modification of the model protein albumin in the presence of fructose as glycating agent (1 mM) | 2003 | Journal of medicinal chemistry, Jan-30, Volume: 46, Issue:3 | Substituted pyrrol-1-ylacetic acids that combine aldose reductase enzyme inhibitory activity and ability to prevent the nonenzymatic irreversible modification of proteins from monosaccharides. |
| AID1348941 | Antioxidant activity assessed as DPPH radical scavenging activity at 30 uM after 60 mins by spectrophotometric method relative to control | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Trisubstituted barbiturates and thiobarbiturates: Synthesis and biological evaluation as xanthine oxidase inhibitors, antioxidants, antibacterial and anti-proliferative agents. |
| AID1083338 | Antiviral activity against Vaccinia virus infected human HEL cells assessed as inhibition of virus-induced cytopathicity | 2011 | Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, , Volume: 20, Issue:2 | The novel amidocarbamate derivatives of ketoprofen: synthesis and biological activity. |
| AID1324204 | Antioxidant activity assessed as ABTS radical scavenging activity after 6 mins by spectrophotometric analysis | 2016 | Bioorganic & medicinal chemistry letters, 11-01, Volume: 26, Issue:21 | Synthesis and anti-inflammatory activity of paeonol analogues in the murine model of complete Freund's adjuvant induced arthritis. |
| AID427664 | Antioxidant activity assessed as ABTS radical scavenging activity | 2009 | Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13 | Potential antioxidants and tyrosinase inhibitors from synthetic polyphenolic deoxybenzoins. |
| AID1406253 | Inhibition of human BChE using butyrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition and measured for 1 min by Ellman's assay | 2018 | European journal of medicinal chemistry, Aug-05, Volume: 156 | Multi-target-directed ligands for treating Alzheimer's disease: Butyrylcholinesterase inhibitors displaying antioxidant and neuroprotective activities. |
| AID1589464 | Antioxidant activity assessed as DPPH radical scavenging activity at 50 uM incubated for 30 mins under dark condition by spectrophotometry | 2019 | European journal of medicinal chemistry, Apr-15, Volume: 168 | Synthesis of new arylsulfonylspiroimidazolidine-2',4'-diones and study of their effect on stimulation of insulin release from MIN6 cell line, inhibition of human aldose reductase, sorbitol accumulations in various tissues and oxidative stress. |
| AID550003 | Antioxidant activity assessed as DPPH radical scavenging activity | 2010 | Journal of natural products, Nov-29, Volume: 73, Issue:11 | Terpenoids from the aerial parts of Parasenecio deltophylla. |
| AID403308 | Antioxidant activity assessed as DPPH radical scavenging activity by HPLC | 2004 | Journal of natural products, Jul, Volume: 67, Issue:7 | New lamellarin alkaloids from the Indian ascidian Didemnum obscurum and their antioxidant properties. |
| AID1592385 | Electrochemical behavior of the compound assessed as redox potential corrected toward saturated Ag/AgCl reference electrode by cyclic voltammetry | |||
| AID653293 | Antioxidant activity assessed as inhibition of AAPH-induced linoleic acid lipid peroxidation by measuring conjugated diene hydroperoxide level | 2012 | European journal of medicinal chemistry, May, Volume: 51 | Novel NSAID 1-acyl-4-cycloalkyl/arylsemicarbazides and 1-acyl-5-benzyloxy/hydroxy carbamoylcarbazides as potential anticancer agents and antioxidants. |
| AID196215 | Ability to protect cerebellar granule cells (CGC) from iodoacetate (IAA)-induced toxicity | 2000 | Journal of medicinal chemistry, Jul-27, Volume: 43, Issue:15 | 3,5-Disubstituted-4-hydroxyphenyls linked to 3-hydroxy-2-methyl-4(1H)-pyridinone: potent inhibitors of lipid peroxidation and cell toxicity. |
| AID770310 | Antioxidant activity assessed as AAPH-induced free radical scavenging activity at 25 uM preincubated for 30 mins followed by AAPH induction measured every 5 mins for 9 hrs by ORAC assay relative to vehicle-treated control | 2013 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 23, Issue:19 | Discovery of novel (1S)-(-)-verbenone derivatives with anti-oxidant and anti-ischemic effects. |
| AID604213 | Antioxidant activity assessed as inhibition of ABTS free radicals at 0.01 mM after 30 mins by UV-visible spectrophotometer analysis relative to control | 2011 | Bioorganic & medicinal chemistry, Jul-01, Volume: 19, Issue:13 | Synthesis and evaluation of fluorescent heterocyclic aminoadamantanes as multifunctional neuroprotective agents. |
| AID1762403 | Inhibition of human erythrocyte AChE using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition by Ellman's method | 2021 | European journal of medicinal chemistry, Jun-05, Volume: 218 | Novel potent bifunctional carboxylesterase inhibitors based on a polyfluoroalkyl-2-imino-1,3-dione scaffold. |
| AID1330213 | Aqueous solubility of the compound in sodium phosphate buffer at pH 6.8 after 90 mins by shake flask method | 2016 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 26, Issue:23 | Synthesis and biological assessment of novel N-(hydroxy/methoxy)alkyl β-enaminone curcuminoids. |
| AID1399484 | Inhibition of porcine liver carboxylesterase using 4-nitrophenol acetate as substrate incubated for 10 mins followed by substrate addition by spectrophotometric method | 2018 | Bioorganic & medicinal chemistry, 09-01, Volume: 26, Issue:16 | Synthesis, molecular docking, and biological activity of 2-vinyl chromones: Toward selective butyrylcholinesterase inhibitors for potential Alzheimer's disease therapeutics. |
| AID1755237 | Antioxidant activity assessed as trolox equivalent antioxidant capacity | |||
| AID1326576 | Cytotoxicity against hamster AG17-1 cells assessed as reduction in cell viability after 72 hrs by MTT assay | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Antioxidant and antitumor activity of trolox, trolox succinate, and α-tocopheryl succinate conjugates with nitroxides. |
| AID751209 | Antioxidant activity assessed as free radical scavenging activity after 7 mins by ABTS radical cation decolorization assay | 2013 | Journal of medicinal chemistry, Jun-27, Volume: 56, Issue:12 | Highly efficient biocompatible neuroprotectants with dual activity as antioxidants and P2Y receptor agonists. |
| AID1228618 | Antioxidant activity assessed as DPPH radical-scavenging activity incubated for 30 mins by spectrophotometry | 2015 | Journal of natural products, May-22, Volume: 78, Issue:5 | Anti-inflammatory Hydrolyzable Tannins from Myricaria bracteata. |
| AID1581664 | Antioxidant activity assessed as increase in total ferric ion reducing activity at 150 uM using FeCl3.H2O and TPTZ incubated for 30 mins by FRAP assay relative to control | 2020 | European journal of medicinal chemistry, Feb-01, Volume: 187 | 1-Benzylpyrrolidine-3-amine-based BuChE inhibitors with anti-aggregating, antioxidant and metal-chelating properties as multifunctional agents against Alzheimer's disease. |
| AID548353 | Neuroprotective activity against rotenone and oligomycin-induced mitochondrial oxidative stress in human SH-SY5Y cells assessed as LDH release at 30 uM after 24 hrs using DCFH-DA fluorescent dye | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | Old phenothiazine and dibenzothiadiazepine derivatives for tomorrow's neuroprotective therapies against neurodegenerative diseases. |
| AID504308 | Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as inhibition of NO production after 24 hrs | 2010 | Journal of natural products, Sep-24, Volume: 73, Issue:9 | Antioxidant and anti-inflammatory phenylpropanoid derivatives from Calamus quiquesetinervius. |
| AID619942 | Antioxidant activity assessed as ferric to ferrous reduction at 30 ug/ml by FRAP assay | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9 | Isoeugenol-based novel potent antioxidants: synthesis and reactivity. |
| AID1563219 | Antioxidant activity in pH 7.4 potassium phosphate buffer assessed as CuCl2/ascorbic acid induced hydroxyl radical scavenging activity by measuring deoxyribose degradation product formation after 20 mins by thiobarbituric acid based absorbance analysis | 2019 | Journal of medicinal chemistry, 07-11, Volume: 62, Issue:13 | Synthesis and Biological Assessment of Pyrrolobenzoxazine Scaffold as a Potent Antioxidant. |
| AID1143750 | Neuroprotective activity in human SH-SY5Y cells assessed as protection against rotenone-oligomycin-induced toxicity at 0.3 uM co-incubated with rotenone-oligomycin measured after 24 hrs by lactate dehydrogenase release assay | 2014 | European journal of medicinal chemistry, Jun-23, Volume: 81 | Dibenzo[1,4,5]thiadiazepine: a hardly-known heterocyclic system with neuroprotective properties of potential usefulness in the treatment of neurodegenerative diseases. |
| AID736835 | Antioxidant activity assessed as DPPH free radical scavenging activity at 20 uM | 2013 | Journal of medicinal chemistry, Feb-14, Volume: 56, Issue:3 | Structure-activity relationship study of vitamin k derivatives yields highly potent neuroprotective agents. |
| AID1071844 | Antioxidant activity assessed as riboflavin/EDTA-induced superoxide anion radical scavenging activity by ESR spin trapping method | 2014 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 24, Issue:5 | A multiple free-radical scavenging (MULTIS) study on the antioxidant capacity of a neuroprotective drug, edaravone as compared with uric acid, glutathione, and trolox. |
| AID1729071 | Antioxidant activity assessed as ABTS radical scavenging activity at 10 uM relative to control | 2021 | European journal of medicinal chemistry, Mar-05, Volume: 213 | A greener protocol for the synthesis of phosphorochalcogenoates: Antioxidant and free radical scavenging activities. |
| AID1810904 | Binding affinity to human serum BChE assessed as half life | |||
| AID1326572 | Cytotoxicity against human CEM13 cells assessed as reduction in cell viability after 72 hrs by MTT assay | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Antioxidant and antitumor activity of trolox, trolox succinate, and α-tocopheryl succinate conjugates with nitroxides. |
| AID490949 | Antioxidant activity assessed as inhibition of lipid peroxidation at 100 uM | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Synthesis and biological screening of some novel amidocarbamate derivatives of ketoprofen. |
| AID247539 | In vitro inhibitory concentration against NO (nitrous oxide) | 2005 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 15, Issue:12 | Nitrone derivatives of trolox as neuroprotective agents. |
| AID616482 | Antioxidant activity assessed as DPPH free radical scavenging activity | 2011 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 21, Issue:18 | Synthesis and antioxygenic activities of seabuckthorn flavone-3-ols and analogs. |
| AID419626 | Antioxidant activity in 2',7'-dichlorodihydrofluorescein diacetate-treated hTERT-HME1 cells assessed as reduction of H2O2 production at 100 uM during after 24 hrs by FACS analysis | 2009 | European journal of medicinal chemistry, Jun, Volume: 44, Issue:6 | Synthesis and antioxidant potential of novel synthetic benzophenone analogues. |
| AID1713240 | Cytotoxicity against human SH-SY5Y cells assessed as cell viability at 0.8 uM measured after 24 hrs by MTT assay relative to control | 2016 | European journal of medicinal chemistry, Nov-10, Volume: 123 | Synthesis and in vitro, ex-vivo and in vivo activity of hybrid compounds linking a potent ROS and RNS scavenger activity with diverse substrates addressed to pass across the blood-brain barrier. |
| AID1713237 | Cytotoxicity against human SH-SY5Y cells assessed as cell viability at 6.3 uM measured after 24 hrs by MTT assay relative to control | 2016 | European journal of medicinal chemistry, Nov-10, Volume: 123 | Synthesis and in vitro, ex-vivo and in vivo activity of hybrid compounds linking a potent ROS and RNS scavenger activity with diverse substrates addressed to pass across the blood-brain barrier. |
| AID1480857 | Neuroprotective activity against glutamate-induced neuronal cell death in mouse HT22 cells assessed as increase in cell viability at 100 uM pretreated for 30 mins followed by glutamate challenge measured after 24 hrs by MTT assay | 2017 | European journal of medicinal chemistry, Apr-21, Volume: 130 | Design, synthesis and evaluation of 2-arylethenyl-N-methylquinolinium derivatives as effective multifunctional agents for Alzheimer's disease treatment. |
| AID1083339 | Antiviral activity against Human herpesvirus 2 strain G infected human HEL cells assessed as inhibition of virus-induced cytopathicity | 2011 | Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, , Volume: 20, Issue:2 | The novel amidocarbamate derivatives of ketoprofen: synthesis and biological activity. |
| AID1428458 | Inhibition of mushroom tyrosinase using L-DOPA as substrate preincubated for 5 mins followed by substrate addition measured for 10 mins by spectrophotometric method | 2016 | Journal of natural products, Dec-23, Volume: 79, Issue:12 | Antioxidant Flavonols and Phenolic Compounds from Atraphaxis frutescens and Their Inhibitory Activities against Insect Phenoloxidase and Mushroom Tyrosinase. |
| AID1083334 | Antiviral activity against Human coxsackievirus B4 infected VERO cells assessed as inhibition of virus-induced cytopathicity | 2011 | Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, , Volume: 20, Issue:2 | The novel amidocarbamate derivatives of ketoprofen: synthesis and biological activity. |
| AID380424 | Cytotoxicity against human HL60 cells by XTT assay | 2006 | Journal of natural products, Mar, Volume: 69, Issue:3 | Schisandrene, a dibenzocyclooctadiene lignan from Schisandra chinensis: structure-antioxidant activity relationships of dibenzocyclooctadiene lignans. |
| AID1083347 | Antioxidant activity assessed as inhibition of AAPH-induced lipid peroxidation at 1 X 10'-4 M | 2011 | Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, , Volume: 20, Issue:2 | The novel amidocarbamate derivatives of ketoprofen: synthesis and biological activity. |
| AID1071842 | Antioxidant activity assessed as t-butylhyroperoxide-induced alkylperoxyl radical scavenging activity by ESR spin trapping method | 2014 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 24, Issue:5 | A multiple free-radical scavenging (MULTIS) study on the antioxidant capacity of a neuroprotective drug, edaravone as compared with uric acid, glutathione, and trolox. |
| AID1659475 | Antioxidant activity assessed as DPPH radical scavenging activity at 100 uM relative to control | 2020 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 30, Issue:9 | Novel quinolin-4(1H)-one derivatives as multi-effective aldose reductase inhibitors for treatment of diabetic complications: Synthesis, biological evaluation, and molecular modeling studies. |
| AID469416 | Neuroprotective activity against human SH-SY5Y cells assessed as cytoprotection at 3 uM coincubated with rotenone/oligomycin A measured after 24 hrs | 2009 | Journal of medicinal chemistry, Nov-26, Volume: 52, Issue:22 | Neuroprotective and cholinergic properties of multifunctional glutamic acid derivatives for the treatment of Alzheimer's disease. |
| AID1379030 | Neuroprotective activity against H2O2-induced oxidative damage in rat PC12 cells assessed as increase in cell viability at 25 uM preincubated for 2 hrs followed by H2O2 challenge measured after 24 hrs by MTT assay | 2017 | European journal of medicinal chemistry, Oct-20, Volume: 139 | Novel cinnamamide-dibenzylamine hybrids: Potent neurogenic agents with antioxidant, cholinergic, and neuroprotective properties as innovative drugs for Alzheimer's disease. |
| AID1603222 | Antioxidant activity in rat brain homogenate assessed as inhibition of FeCl2/ascorbic acid-induced lipid peroxidation by measuring reduction in TBARS level at 50 uM measured after 30 mins by spectrophotometric method relative to control | 2019 | Bioorganic & medicinal chemistry, 04-15, Volume: 27, Issue:8 | Designing of acyl sulphonamide based quinoxalinones as multifunctional aldose reductase inhibitors. |
| AID387150 | Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins | 2008 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 18, Issue:18 | ortho-dihydroxyisoflavone derivatives from aged Doenjang (Korean fermented soypaste) and its radical scavenging activity. |
| AID1143541 | Antioxidant activity assessed as galvinoxyl radical scavenging activity by spectrophotometric analysis | 2014 | European journal of medicinal chemistry, Jun-23, Volume: 81 | Thiaflavan scavenges radicals and inhibits DNA oxidation: a story from the ferrocene modification. |
| AID1655201 | Antioxidant activity assessed as ABTS radical scavenging activity incubated for 40 mins | 2020 | ACS medicinal chemistry letters, May-14, Volume: 11, Issue:5 | Synthesis, Cytotoxicity Evaluation, and Computational Insights of Novel 1,4-Diazepane-Based Sigma Ligands. |
| AID1238056 | Antioxidant activity assessed as DPPH radical scavenging activity at 200 uM incubated for 30 mins under dark conditions | 2015 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 25, Issue:16 | Nitric oxide inhibitory activity and antioxidant evaluations of 2-benzoyl-6-benzylidenecyclohexanone analogs, a novel series of curcuminoid and diarylpentanoid derivatives. |
| AID1333862 | Antioxidant activity assessed as ABTS radical scavenging activity at 100 ug/ml after 30 mins | 2017 | Bioorganic & medicinal chemistry letters, 01-01, Volume: 27, Issue:1 | Synthesis of new morpholine-connected pyrazolidine derivatives and their antimicrobial, antioxidant, and cytotoxic activities. |
| AID469414 | Neuroprotective activity against human SH-SY5Y cells assessed as cytoprotection at 0.3 uM coincubated with rotenone/oligomycin A measured after 24 hrs | 2009 | Journal of medicinal chemistry, Nov-26, Volume: 52, Issue:22 | Neuroprotective and cholinergic properties of multifunctional glutamic acid derivatives for the treatment of Alzheimer's disease. |
| AID497112 | Antioxidant activity assessed as ABTS free radical scavenging activity after 12 hrs | 2010 | Bioorganic & medicinal chemistry, Aug-01, Volume: 18, Issue:15 | Synthesis and biological evaluation of arylidene analogues of Meldrum's acid as a new class of antimalarial and antioxidant agents. |
| AID1436860 | Antioxidant activity assessed as DPPH radical scavenging activity at 10 uM after 240 mins by UV spectrophotometer relative to control | 2017 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 27, Issue:4 | Synthesis and structure-activity relationship studies of phenolic hydroxyl derivatives based on quinoxalinone as aldose reductase inhibitors with antioxidant activity. |
| AID1324203 | Antioxidant activity assessed as hydroxyl radical scavenging activity measured 10 mins after H2O2 addition by pyronin B dye based assay | 2016 | Bioorganic & medicinal chemistry letters, 11-01, Volume: 26, Issue:21 | Synthesis and anti-inflammatory activity of paeonol analogues in the murine model of complete Freund's adjuvant induced arthritis. |
| AID1647679 | Neuroprotective activity in human SH-SY5Y cells assessed as reduction in H2O2-induced cell death at 1 uM preincubated for 1 hr followed by H2O2 addition and measured after 4 hrs by MTT assay relative to control | 2020 | Journal of natural products, 02-28, Volume: 83, Issue:2 | Modified Eremophilanes from |
| AID1755235 | Inhibition of amyloid beta (1 to 42) (unknown origin) self-induced aggregation incubated for 24 hrs by Thioflavin T based fluorometric assay | |||
| AID288848 | Antioxidant activity assessed as ABTS radical scavenging activity after 30 mins | 2007 | Journal of natural products, Jun, Volume: 70, Issue:6 | Cyathusals A, B, and C, antioxidants from the fermented mushroom Cyathus stercoreus. |
| AID264484 | Inhibition of doxorubicin-induced death of mixed cortical cells of E15 Sprague-Dawley rat embryo at 10 uM | 2006 | Journal of medicinal chemistry, May-04, Volume: 49, Issue:9 | Fluorinated amphiphilic amino acid derivatives as antioxidant carriers: a new class of protective agents. |
| AID1493751 | Antioxidant activity assessed as cupric ion reducing activity after 30 mins by CUPRAC assay | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Design, synthesis and biochemical evaluation of novel multi-target inhibitors as potential anti-Parkinson agents. |
| AID1320870 | Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured for 5 mins by Ellman's method | 2016 | European journal of medicinal chemistry, Oct-04, Volume: 121 | New cinnamic - N-benzylpiperidine and cinnamic - N,N-dibenzyl(N-methyl)amine hybrids as Alzheimer-directed multitarget drugs with antioxidant, cholinergic, neuroprotective and neurogenic properties. |
| AID1480864 | Neuroprotective activity against glutamate-induced neuronal cell death in mouse HT22 cells assessed as intracellular reactive oxygen species level at 50 uM pretreated for 30 mins followed by glutamate challenge measured after 6 hrs by DCFH-DA probe based | 2017 | European journal of medicinal chemistry, Apr-21, Volume: 130 | Design, synthesis and evaluation of 2-arylethenyl-N-methylquinolinium derivatives as effective multifunctional agents for Alzheimer's disease treatment. |
| AID1624744 | Antioxidant activity assessed as ABTS radical cation scavenging activity by measuring trolox equivalents at 10 uL after 1 min | 2019 | Journal of medicinal chemistry, 02-28, Volume: 62, Issue:4 | New Quinolylnitrones for Stroke Therapy: Antioxidant and Neuroprotective ( Z)- N- tert-Butyl-1-(2-chloro-6-methoxyquinolin-3-yl)methanimine Oxide as a New Lead-Compound for Ischemic Stroke Treatment. |
| AID1592389 | Cytotoxicity against human HepG2 cells assessed as cell metabolic activity at 50 uM incubated for 48 hrs by resazurin assay relative to control | |||
| AID1306594 | Cytotoxicity against HMEC1 assessed as cell viability at 1 uM after 24 hrs by MTT assay in absence of oxidized LDL | 2016 | Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16 | Synthesis and evaluation of antioxidant phenolic diaryl hydrazones as potent antiangiogenic agents in atherosclerosis. |
| AID1256880 | Inhibition of human recombinant AChE using acetylthiocholine as substrate preincubated for 5 mins followed by substrate addition measured every 2 mins by Ellman's method | 2015 | Journal of medicinal chemistry, Nov-25, Volume: 58, Issue:22 | Tacrine-Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity. |
| AID445120 | Antioxidant activity assessed as protection against AAPH-induced pBR322 plasmid DNA strand open circular form at 0.35 to 45 uM after 4 hrs by agarose gel electrophoresis | 2009 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 19, Issue:22 | Synthesis and antioxidant properties of dendritic polyphenols. |
| AID1141997 | Antioxidant activity assessed as inhibition of AAPH-induced linoleic acid peroxidation by UV spectrophotometric analysis | 2014 | European journal of medicinal chemistry, Jun-10, Volume: 80 | Synthesis of stable aromatic and heteroaromatic sulfonyl-amidoximes and evaluation of their antioxidant and lipid peroxidation activity. |
| AID1306597 | Antiangiogenic activity in HMEC1 assessed as inhibition of oxidized LDL induced tube formation at 10 uM after 18 hrs by calcein staining based fluorescence microscopy | 2016 | Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16 | Synthesis and evaluation of antioxidant phenolic diaryl hydrazones as potent antiangiogenic agents in atherosclerosis. |
| AID504305 | Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins by ELISA reader | 2010 | Journal of natural products, Sep-24, Volume: 73, Issue:9 | Antioxidant and anti-inflammatory phenylpropanoid derivatives from Calamus quiquesetinervius. |
| AID1480859 | Neuroprotective activity against glutamate-induced neuronal cell death in mouse HT22 cells assessed as normal neurite appearance at 100 uM pretreated for 30 mins followed by glutamate challenge measured after 18 hrs by phase-contrast microscopic method | 2017 | European journal of medicinal chemistry, Apr-21, Volume: 130 | Design, synthesis and evaluation of 2-arylethenyl-N-methylquinolinium derivatives as effective multifunctional agents for Alzheimer's disease treatment. |
| AID1596340 | Antioxidant activity assessed as DPPH free radical scavenging activity after 30 mins incubation in dark by UV-Visible spectrophotometric analysis | 2019 | European journal of medicinal chemistry, Jul-15, Volume: 174 | Multi-targeted ChEI-copper chelating molecules as neuroprotective agents. |
| AID1326577 | Cytotoxicity against human MCF7 cells assessed as reduction in cell viability at 300 uM after 72 hrs by MTT assay | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Antioxidant and antitumor activity of trolox, trolox succinate, and α-tocopheryl succinate conjugates with nitroxides. |
| AID490422 | Antioxidant activity against superoxide radical generation in HMEC1 cells | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Synthesis and antioxidant activity evaluation of a syringic hydrazones family. |
| AID1729655 | Neuroprotective activity against H2O2-induced lipid peroxidation in mouse SN-56 cells assessed as increase in MDA level at 100 uM incubated for 24 hrs by lipid peroxidation MDA assay kit method | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Discovery of 7-aminophenanthridin-6-one as a new scaffold for matrix metalloproteinase inhibitors with multitarget neuroprotective activity. |
| AID471313 | Antioxidant activity assessed as DPPH radical scavenging activity | 2009 | European journal of medicinal chemistry, Dec, Volume: 44, Issue:12 | Captopril and 6-mercaptopurine: whose SH possesses higher antioxidant ability? |
| AID1474954 | Antioxidant activity assessed as ABTS radical scavenging activity incubated for 2 hrs in dark by spectrophotometric analysis | 2017 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11 | Stereoselective synthesis of enantiopure N-substituted pyrrolidin-2,5-dione derivatives by 1,3-dipolar cycloaddition and assessment of their in vitro antioxidant and antibacterial activities. |
| AID440884 | Antioxidant activity against Fe3+/ascorbic acid system generated hydroxyl radicals assessed as inhibition of formaldehyde production at 0.1 mM | 2009 | European journal of medicinal chemistry, Dec, Volume: 44, Issue:12 | Synthesis and anti-inflammatory evaluation of novel angularly or linearly fused coumarins. |
| AID1678471 | Antioxidant activity in pH 7.4 phosphate buffer assessed as PTIO radical scavenging activity after 1 hr by microplate reader based assay | 2020 | ACS medicinal chemistry letters, Nov-12, Volume: 11, Issue:11 | Covalent Bridging of Corilagin Improves Antiferroptosis Activity: Comparison with 1,3,6-Tri- |
| AID1859601 | Antioxidant activity assessed as DPPH radical scavenging activity incubated for 1 hrs under dark condition by DPPH assay | 2022 | European journal of medicinal chemistry, Aug-05, Volume: 238 | Halogen substituents enhance oxime nucleophilicity for reactivation of cholinesterases inhibited by nerve agents. |
| AID1534714 | Antioxidant activity assessed as inhibition of DPPH free radical after 30 mins by UV-Visible spectrophotometric analysis | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Synthesis and evaluation of isoprenylation-resveratrol dimer derivatives against Alzheimer's disease. |
| AID778759 | Antioxidant activity assessed as inhibition of H2O2-induced ROS production by DCFH assay | 2013 | Journal of medicinal chemistry, Sep-12, Volume: 56, Issue:17 | Multifunctional cyclic D,L-α-peptide architectures stimulate non-insulin dependent glucose uptake in skeletal muscle cells and protect them against oxidative stress. |
| AID1651606 | Cytoprotective activity against LPS-induced NRK-52E cells assessed as reduction in cell death measured every 5 min for 72 hrs by xCELLigence based RTCA analysis | 2020 | Journal of natural products, 04-24, Volume: 83, Issue:4 | Renoprotective Mono- and Triterpenoids from the Fruit of |
| AID1264037 | Neuroprotective activity against Fenton reagent-induced ROS generation-stimulated cytotoxicity in human ARPE19 cells assessed as cell viability at 1 mM after 2 hrs by MTS assay | 2015 | Journal of medicinal chemistry, Nov-25, Volume: 58, Issue:22 | Orally Bioavailable Metal Chelators and Radical Scavengers: Multifunctional Antioxidants for the Coadjutant Treatment of Neurodegenerative Diseases. |
| AID1298959 | Antioxidant activity assessed as DPPH free radical scavenging activity at 10 uM after 40 mins by UV-Vis spectrophotometry | 2016 | Bioorganic & medicinal chemistry letters, 06-15, Volume: 26, Issue:12 | Synthesis of benzothiadiazine derivatives exhibiting dual activity as aldose reductase inhibitors and antioxidant agents. |
| AID1326571 | Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by MTT assay | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Antioxidant and antitumor activity of trolox, trolox succinate, and α-tocopheryl succinate conjugates with nitroxides. |
| AID1306596 | Cytoprotective activity in HMEC1 assessed as inhibition of oxidized LDL induced toxicity measured as residual viability at 10 uM after 24 hrs by MTT assay (Rvb = 20 +/- 5 %) | 2016 | Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16 | Synthesis and evaluation of antioxidant phenolic diaryl hydrazones as potent antiangiogenic agents in atherosclerosis. |
| AID1326569 | Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Antioxidant and antitumor activity of trolox, trolox succinate, and α-tocopheryl succinate conjugates with nitroxides. |
| AID1511011 | Antioxidant activity assessed as ABTS radical scavenging activity incubated for 40 mins | 2019 | European journal of medicinal chemistry, Oct-15, Volume: 180 | Discovery of new potent dual sigma receptor/GluN2b ligands with antioxidant property as neuroprotective agents. |
| AID1713236 | Cytotoxicity against human SH-SY5Y cells assessed as cell viability at 12.5 uM measured after 24 hrs by MTT assay relative to control | 2016 | European journal of medicinal chemistry, Nov-10, Volume: 123 | Synthesis and in vitro, ex-vivo and in vivo activity of hybrid compounds linking a potent ROS and RNS scavenger activity with diverse substrates addressed to pass across the blood-brain barrier. |
| AID377346 | Antioxidant activity assessed as ABTS radical scavenging activity | 2005 | Journal of natural products, Feb, Volume: 68, Issue:2 | Resveratrol derivatives from the roots of Vitis thunbergii. |
| AID406771 | DPPH radical scavenging activity at 200 uM | 2008 | Journal of medicinal chemistry, Jul-10, Volume: 51, Issue:13 | Efficient synthesis and neuroprotective effect of substituted 1,3-diphenyl-2-propen-1-ones. |
| AID1720092 | Antioxidant activity assessed as ABTS radical scavenging activity incubated in dark for 1 min | 2020 | Bioorganic & medicinal chemistry, 06-01, Volume: 28, Issue:11 | Discovery of a new potent inhibitor of mushroom tyrosinase (Agaricus bisporus) containing 4-(4-hydroxyphenyl)piperazin-1-yl moiety. |
| AID1372026 | Antioxidant activity assessed as relative scavenging rate constant for photolysis-induced methyl radical scavenging activity by measuring Kaox/Kst ratio using DMPO spin trap by ESR spectroscopic method | 2017 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23 | Resveratrol analogues like piceatannol are potent antioxidants as quantitatively demonstrated through the high scavenging ability against reactive oxygen species and methyl radical. |
| AID1543559 | Antioxidant activity assessed as ABTS radical scavenging activity incubated for 6 mins | 2019 | European journal of medicinal chemistry, Apr-01, Volume: 167 | Synthesis and evaluation of novel GSK-3β inhibitors as multifunctional agents against Alzheimer's disease. |
| AID1083340 | Antiviral activity against Human simplex virus 1 KOS infected in human HEL cells assessed as inhibition of virus-induced cytopathicity | 2011 | Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, , Volume: 20, Issue:2 | The novel amidocarbamate derivatives of ketoprofen: synthesis and biological activity. |
| AID1892585 | Antioxidant activity assessed as DPPH radical scavenging activity at 10 uM incubated for 30 mins by DPPH assay relative to control | 2022 | Journal of medicinal chemistry, 07-14, Volume: 65, Issue:13 | Novel Hydroxychalcone-Based Dual Inhibitors of Aldose Reductase and α-Glucosidase as Potential Therapeutic Agents against Diabetes Mellitus and Its Complications. |
| AID1327542 | Reactive carbonyl species trapping activity of compound assessed as MGO adduct formation at 10 mM preincubated for 24 hrs with MGO measured after 15 mins by LCMS analysis | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Multifunctional diamine AGE/ALE inhibitors with potential therapeutical properties against Alzheimer's disease. |
| AID1405944 | Antioxidant activity assessed as inhibition of lipid peroxidation relative to control | 2018 | European journal of medicinal chemistry, Aug-05, Volume: 156 | Current progress on antioxidants incorporating the pyrazole core. |
| AID427138 | Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins | 2009 | Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13 | p-Terphenyls from the fruiting bodies of Paxillus curtisii and their antioxidant properties. |
| AID635126 | Cytotoxicity against mouse Melan-a cells by modified crystal voilet assay | 2011 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 21, Issue:24 | Inhibitory activity of novel kojic acid derivative containing trolox moiety on melanogenesis. |
| AID380423 | Antioxidant activity in human HL60 cells assessed as inhibition of TPA-stimulated hydrogen peroxide induced DCFH-DA oxidation by fluorometric microplate assay | 2006 | Journal of natural products, Mar, Volume: 69, Issue:3 | Schisandrene, a dibenzocyclooctadiene lignan from Schisandra chinensis: structure-antioxidant activity relationships of dibenzocyclooctadiene lignans. |
| AID1071840 | Antioxidant activity assessed as rosebengal-induced singlet oxygen radical scavenging activity by ESR spin trapping method | 2014 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 24, Issue:5 | A multiple free-radical scavenging (MULTIS) study on the antioxidant capacity of a neuroprotective drug, edaravone as compared with uric acid, glutathione, and trolox. |
| AID1713230 | Cytotoxicity against human SH-SY5Y cells assessed as cell viability at 3.1 uM measured after 2 hrs by MTT assay relative to control | 2016 | European journal of medicinal chemistry, Nov-10, Volume: 123 | Synthesis and in vitro, ex-vivo and in vivo activity of hybrid compounds linking a potent ROS and RNS scavenger activity with diverse substrates addressed to pass across the blood-brain barrier. |
| AID1762408 | Antioxidant activity assessed as decrease in ABTS radical cation scavenging activity incubated for 24 hrs by UV-Vis spectrophotometric analysis | 2021 | European journal of medicinal chemistry, Jun-05, Volume: 218 | Novel potent bifunctional carboxylesterase inhibitors based on a polyfluoroalkyl-2-imino-1,3-dione scaffold. |
| AID598280 | Antioxidant activity in rat liver homogenates assessed as inhibition of iron-ascorbic acid mix-induced lipid peroxidation after 30 mins by TBARS assay | 2011 | European journal of medicinal chemistry, May, Volume: 46, Issue:5 | Synthesis of chromone carboxamide derivatives with antioxidative and calpain inhibitory properties. |
| AID537163 | DPPH radical scavenging activity assessed as initial rate of interaction at 0.2 mM | 2010 | Journal of medicinal chemistry, Nov-11, Volume: 53, Issue:21 | A diverse series of substituted benzenesulfonamides as aldose reductase inhibitors with antioxidant activity: design, synthesis, and in vitro activity. |
| AID724354 | Antioxidant activity assessed as inhibition of AAPH-induced linoleic acid lipid peroxidation at 100 uM by spectrophotometric analysis | 2013 | European journal of medicinal chemistry, Feb, Volume: 60 | Syntheses and evaluation of the antioxidant activity of novel methoxypsoralen derivatives. |
| AID1173942 | Antioxidant activity assessed as inhibition of AAPH-induced linoleic acid lipid peroxidation at 100 uM | 2014 | Bioorganic & medicinal chemistry, Dec-01, Volume: 22, Issue:23 | Structural modifications of coumarin derivatives: Determination of antioxidant and lipoxygenase (LOX) inhibitory activity. |
| AID1810910 | Inhibition of human AChE using acetylthiocholine iodide as substrate at 10 uM incubated for 20 mins followed by substrate addition by Ellman's method | |||
| AID1399482 | Inhibition of equine serum BChE using butylthiocholine iodide as substrate incubated for 10 mins followed by substrate addition by Ellman's method | 2018 | Bioorganic & medicinal chemistry, 09-01, Volume: 26, Issue:16 | Synthesis, molecular docking, and biological activity of 2-vinyl chromones: Toward selective butyrylcholinesterase inhibitors for potential Alzheimer's disease therapeutics. |
| AID363318 | DPPH radical scavenging activity assessed as ratio of drug concentration to DPPH concentration producing 50% decrease in DPPH after 5 mins | 2008 | European journal of medicinal chemistry, Jun, Volume: 43, Issue:6 | Synthesis and biological activities of a series of 4,5-diaryl-3-hydroxy-2(5H)-furanones. |
| AID1277568 | Antioxidant activity assessed as suppression of H2O2/DETAPAC-Fe2+-mediated hydroxyl radical formation by measuring oxidation of dihydrorhodamine after 5 mins by fluorescence assay | 2016 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 26, Issue:4 | Synthesis and biological evaluation of novel orally available 1-phenyl-6-aminouracils containing dimethyldihydrobenzofuranol structure for the treatment of allergic skin diseases. |
| AID1257023 | Anti-inflammatory activity in Fisher 344 rat assessed as inhibition of carrageenan-induced paw edema at 0.01 mmol/kg, ip after 3.5 hrs | 2015 | Bioorganic & medicinal chemistry, Nov-15, Volume: 23, Issue:22 | Synthesis and biological evaluation of new C-10 substituted dithranol pleiotropic hybrids. |
| AID1143753 | Antioxidant activity in human SH-SY5Y cells assessed as rotenone-oligomycin-induced sequestering of mitochondrial free radicals at 0.3 uM after 120 mins using DCFH-DA by fluorescence microplate reader analysis | 2014 | European journal of medicinal chemistry, Jun-23, Volume: 81 | Dibenzo[1,4,5]thiadiazepine: a hardly-known heterocyclic system with neuroprotective properties of potential usefulness in the treatment of neurodegenerative diseases. |
| AID184572 | Inhibition of spontaneous lipid peroxidation at 10e-5 M in rat brain homogenate | 1994 | Journal of medicinal chemistry, Sep-02, Volume: 37, Issue:18 | Benzoselenazolinone derivatives designed to be glutathione peroxidase mimetics feature inhibition of cyclooxygenase/5-lipoxygenase pathways and anti-inflammatory activity. |
| AID1465114 | Inhibition of pig liver carboxylesterase using 4-nitrophenol acetate as substrate by spectrophotometric analysis | 2017 | Bioorganic & medicinal chemistry, 11-01, Volume: 25, Issue:21 | 9-Substituted acridine derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors possessing antioxidant activity for Alzheimer's disease treatment. |
| AID548348 | Neuroprotective activity against H2O2-induced oxidative stress in human SH-SY5Y cells assessed as LDH release at 30 uM after 24 hrs by UV-vis spectroscopy | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | Old phenothiazine and dibenzothiadiazepine derivatives for tomorrow's neuroprotective therapies against neurodegenerative diseases. |
| AID1372028 | Antioxidant activity assessed as relative scavenging rate constant for photolysis-induced peroxyl scavenging activity by measuring Kaox/Kst ratio using CYPMPO spin trap by ESR spectroscopic method | 2017 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23 | Resveratrol analogues like piceatannol are potent antioxidants as quantitatively demonstrated through the high scavenging ability against reactive oxygen species and methyl radical. |
| AID1592386 | Electrochemical behavior of the compound assessed as redox potential corrected toward saturated Ag/AgCl reference electrode by differential pulse voltammetry | |||
| AID1264028 | Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability at 1 mM after 2 hrs by MTS assay | 2015 | Journal of medicinal chemistry, Nov-25, Volume: 58, Issue:22 | Orally Bioavailable Metal Chelators and Radical Scavengers: Multifunctional Antioxidants for the Coadjutant Treatment of Neurodegenerative Diseases. |
| AID762874 | Antioxidant activity assessed as hydroxyl radical scavenging activity at 1 mM after 5 mins by ESR spectroscopy analysis | 2013 | Journal of medicinal chemistry, Aug-08, Volume: 56, Issue:15 | Synthesis and electrochemical and biological studies of novel coumarin-chalcone hybrid compounds. |
| AID406772 | DPPH radical scavenging activity at 10 uM | 2008 | Journal of medicinal chemistry, Jul-10, Volume: 51, Issue:13 | Efficient synthesis and neuroprotective effect of substituted 1,3-diphenyl-2-propen-1-ones. |
| AID1374850 | Neuroprotective activity against tetracycline removal-induced cytotoxicity in human MC65 cells assessed as reduction in oxidative stress at 32 uM after 48 hrs by DCFH-DA dye based fluorescence assay | 2018 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 28, Issue:6 | Design and characterization of bivalent compounds as potential neuroprotectants for Alzheimer's disease: Impact of the spacer on biological activity. |
| AID459653 | Cytotoxicity against human SH-SY5Y cells assessed as plasma membrane damage at 60 uM after 7 days by LDH assay | 2010 | Bioorganic & medicinal chemistry, Mar-01, Volume: 18, Issue:5 | Exploring a synthetic organoselenium compound for antioxidant pharmacotherapy--toxicity and effects on ROS-production. |
| AID341426 | Antioxidant activity against tert-butyl hydroperoxide-induced ROS evoked cell death in human SH-SY5Y cells | 2008 | Journal of medicinal chemistry, Aug-14, Volume: 51, Issue:15 | Inhibition of acetylcholinesterase, beta-amyloid aggregation, and NMDA receptors in Alzheimer's disease: a promising direction for the multi-target-directed ligands gold rush. |
| AID504306 | Antioxidant activity assessed as hydroxyl radical scavenging activity by chemiluminescence analysis | 2010 | Journal of natural products, Sep-24, Volume: 73, Issue:9 | Antioxidant and anti-inflammatory phenylpropanoid derivatives from Calamus quiquesetinervius. |
| AID264483 | Inhibition of peroxynitrite-induced death of mixed cortical cells of E15 Sprague-Dawley rat embryo at 10 uM | 2006 | Journal of medicinal chemistry, May-04, Volume: 49, Issue:9 | Fluorinated amphiphilic amino acid derivatives as antioxidant carriers: a new class of protective agents. |
| AID286756 | Antioxidant activity assessed as DPPH reducing activity at 0.5 mM after 60 mins | 2007 | Journal of medicinal chemistry, May-17, Volume: 50, Issue:10 | Design and synthesis of novel quinolinone-3-aminoamides and their alpha-lipoic acid adducts as antioxidant and anti-inflammatory agents. |
| AID1493977 | Antiproliferative activity against human WiDr cells after 48 hrs by SRB assay | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | A green multicomponent synthesis of tocopherol analogues with antiproliferative activities. |
| AID1269946 | Antioxidant activity assessed as DPPH radical scavenging activity incubated for 20 mins by spectrophotometry analysis | 2016 | Bioorganic & medicinal chemistry, Feb-15, Volume: 24, Issue:4 | An appraisal on recent medicinal perspective of curcumin degradant: Dehydrozingerone (DZG). |
| AID1320874 | Inhibition of human recombinant MAOA using p-tyramine as substrate incubated for 15 mins by fluorimetric method | 2016 | European journal of medicinal chemistry, Oct-04, Volume: 121 | New cinnamic - N-benzylpiperidine and cinnamic - N,N-dibenzyl(N-methyl)amine hybrids as Alzheimer-directed multitarget drugs with antioxidant, cholinergic, neuroprotective and neurogenic properties. |
| AID1320862 | Antioxidant activity assessed as AAPH free radical scavenging activity measured every min during 240 mins by fluorescein-based oxygen radical absorption capacity assay | 2016 | European journal of medicinal chemistry, Oct-04, Volume: 121 | Do cinnamylideneacetophenones have antioxidant properties and a protective effect toward the oxidation of phosphatidylcholines? |
| AID1592388 | Cytotoxicity against human SH-SY5Y cells assessed as cell metabolic activity at 10 uM incubated for 24 hrs by MTT assay relative to control | |||
| AID1503623 | Antioxidant activity assessed as DPPH radical scavenging activity incubated for 60 mins under dark condition by spectrophotometry | 2017 | European journal of medicinal chemistry, Dec-01, Volume: 141 | Nature-based molecules combined with rivastigmine: A symbiotic approach for the synthesis of new agents against Alzheimer's disease. |
| AID497110 | Antioxidant activity assessed as ABTS free radical scavenging activity at 100 uM after 12 hrs | 2010 | Bioorganic & medicinal chemistry, Aug-01, Volume: 18, Issue:15 | Synthesis and biological evaluation of arylidene analogues of Meldrum's acid as a new class of antimalarial and antioxidant agents. |
| AID668901 | Cytotoxicity against mouse RAW264.7 cells at 50 uM by MTT assay | 2011 | European journal of medicinal chemistry, Feb, Volume: 46, Issue:2 | Synthesis and effects of some novel tetrahydronaphthalene derivatives on proliferation and nitric oxide production in lipopolysaccharide activated Raw 264.7 macrophages. |
| AID1325286 | Antioxidant activity assessed as ferric ion reducing activity by measuring Fe2+ levels using fe3+-TPTZ at 375 ug/ml after 30 mins by FRAP assay | 2016 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 26, Issue:22 | Antioxidant and anti-inflammatory neolignans from the seeds of hawthorn. |
| AID469411 | Neuroprotective activity against rotenone/oligomycin A-treated human SH-SY5Y cells assessed as cytoprotection at 1 uM pretreated 24 hrs before rotenone/oligomycin A challenge | 2009 | Journal of medicinal chemistry, Nov-26, Volume: 52, Issue:22 | Neuroprotective and cholinergic properties of multifunctional glutamic acid derivatives for the treatment of Alzheimer's disease. |
| AID1428597 | Antioxidant activity assessed as ABTS radical scavenging activity incubated for 10 mins under dark condition | 2017 | European journal of medicinal chemistry, Feb-15, Volume: 127 | Synthesis and biological evaluation of deferiprone-resveratrol hybrids as antioxidants, Aβ |
| AID289269 | Reduction of hydroxyl radical activity at 0.1 mM in presence of 33 nM DMSO | 2007 | Bioorganic & medicinal chemistry, Sep-01, Volume: 15, Issue:17 | Synthesis and pharmacochemical evaluation of novel aryl-acetic acid inhibitors of lipoxygenase, antioxidants, and anti-inflammatory agents. |
| AID639371 | Neuroprotective activity against H2O2-induced cell death in human SH-SY5Y cells assessed as LDH release at 30 uM incubated for 24 hrs before H2O2 challenge measured after 24 hrs relative to control | 2011 | European journal of medicinal chemistry, Jun, Volume: 46, Issue:6 | N-acylaminophenothiazines: neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease. |
| AID1581651 | Antioxidant activity assessed as ABTS radical scavenging activity at 75 uM measured after 5 mins by spectrophotometric assay relative to control | 2020 | European journal of medicinal chemistry, Feb-01, Volume: 187 | 1-Benzylpyrrolidine-3-amine-based BuChE inhibitors with anti-aggregating, antioxidant and metal-chelating properties as multifunctional agents against Alzheimer's disease. |
| AID1624743 | Antioxidant activity assessed as inhibition of linoleic acid peroxidation activity at 10 uL | 2019 | Journal of medicinal chemistry, 02-28, Volume: 62, Issue:4 | New Quinolylnitrones for Stroke Therapy: Antioxidant and Neuroprotective ( Z)- N- tert-Butyl-1-(2-chloro-6-methoxyquinolin-3-yl)methanimine Oxide as a New Lead-Compound for Ischemic Stroke Treatment. |
| AID613906 | Antioxidant activity in human SH-SY5Y cells assessed as decrease of tert-butyl hydroperoxide-induced ROS production at 20 uM after 24 hrs using DCFH-DA by fluorescence assay | 2011 | Bioorganic & medicinal chemistry, Sep-15, Volume: 19, Issue:18 | Design, synthesis, and biological evaluation of curcumin analogues as multifunctional agents for the treatment of Alzheimer's disease. |
| AID303036 | Antioxidant activity assessed as hydroxyl radical scavenging activity at 0.1 mM | 2007 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 17, Issue:23 | Synthesis and anti-inflammatory/antioxidant activities of some new ring substituted 3-phenyl-1-(1,4-di-N-oxide quinoxalin-2-yl)-2-propen-1-one derivatives and of their 4,5-dihydro-(1H)-pyrazole analogues. |
| AID731499 | Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins | 2013 | Journal of natural products, Jan-25, Volume: 76, Issue:1 | Neolignanamides, lignanamides, and other phenolic compounds from the root bark of Lycium chinense. |
| AID1581665 | Antioxidant activity assessed as increase in total ferric ion reducing activity at 30 uM using FeCl3.H2O and TPTZ incubated for 60 mins by FRAP assay relative to control | 2020 | European journal of medicinal chemistry, Feb-01, Volume: 187 | 1-Benzylpyrrolidine-3-amine-based BuChE inhibitors with anti-aggregating, antioxidant and metal-chelating properties as multifunctional agents against Alzheimer's disease. |
| AID1306593 | Antioxidant activity in HMEC1 assessed as inhibition of cell induced LDL oxidation by measuring TBARS level at 10 uM relative to control | 2016 | Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16 | Synthesis and evaluation of antioxidant phenolic diaryl hydrazones as potent antiangiogenic agents in atherosclerosis. |
| AID445118 | Antioxidant activity assessed as DPPH free radical scavenging activity within 1 mins | 2009 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 19, Issue:22 | Synthesis and antioxidant properties of dendritic polyphenols. |
| AID1678097 | Antioxidant activity assessed as superoxide anion radical scavenging activity incubated for 40 mins by spectrophotometric method | 2020 | Bioorganic & medicinal chemistry, 10-15, Volume: 28, Issue:20 | Dihydrobenzoxazinone derivatives as aldose reductase inhibitors with antioxidant activity. |
| AID334586 | Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins by spectrophotometry | 2002 | Journal of natural products, May, Volume: 65, Issue:5 | 2,3,4-Trimethyl-5,7-dihydroxy-2,3-dihydrobenzofuran, a novel antioxidant, from Penicillium citrinum F5. |
| AID1729063 | Antioxidant activity assessed as ferric ion reducing activity by measuring absorbance at 10 uM measured after 40 mins by FRAP assay (Rvb = 0.11 +/- 0.02 No_unit) | 2021 | European journal of medicinal chemistry, Mar-05, Volume: 213 | A greener protocol for the synthesis of phosphorochalcogenoates: Antioxidant and free radical scavenging activities. |
| AID247576 | In vitro inhibitory concentration against lipid peroxidation (LPO) | 2005 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 15, Issue:12 | Nitrone derivatives of trolox as neuroprotective agents. |
| AID639372 | Neuroprotective activity against rotenone/oligomycin A-induced cell death in human SH-SY5Y cells assessed as LDH release at 0.1 uM treated 24 hrs before rotenone/oligomycin A challenge measured after 24 hrs relative to control | 2011 | European journal of medicinal chemistry, Jun, Volume: 46, Issue:6 | N-acylaminophenothiazines: neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease. |
| AID1242920 | Antioxidant activity assessed as DPPH radical scavenging activity at 100 uM after 240 mins by spectrophotometric analysis relative to control | 2015 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 25, Issue:18 | Phenolic 4-hydroxy and 3,5-dihydroxy derivatives of 3-phenoxyquinoxalin-2(1H)-one as potent aldose reductase inhibitors with antioxidant activity. |
| AID1810884 | Antioxidant activity assessed as DPPH radical scavenging activity incubated for 30 mins by spectrophotometric analysis | |||
| AID220030 | Antioxidant activity in bovine heart mitochondria using iron(II) / dihydroxy fumaric acid (DHF) | 1993 | Journal of medicinal chemistry, May-14, Volume: 36, Issue:10 | Long-chain-substituted uric acid and 5,6-diaminouracil derivatives as novel agents against free radical processes: synthesis and in vitro activity. |
| AID1424235 | Antioxidant activity assessed as alkoxyl radical scavenging activity by measuring rate constant by ESR spin trapping method | 2017 | European journal of medicinal chemistry, Jun-16, Volume: 133 | Free radicals and polyphenols: The redox chemistry of neurodegenerative diseases. |
| AID1348942 | Antioxidant activity assessed as DPPH radical scavenging activity after 20 mins by spectrophotometric method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Trisubstituted barbiturates and thiobarbiturates: Synthesis and biological evaluation as xanthine oxidase inhibitors, antioxidants, antibacterial and anti-proliferative agents. |
| AID1143749 | Neuroprotective activity in human SH-SY5Y cells assessed as protection against rotenone-oligomycin-induced toxicity at 3 uM preincubated for 24 hrs before rotenone-oligomycin addition measured after 24 hrs by lactate dehydrogenase release assay | 2014 | European journal of medicinal chemistry, Jun-23, Volume: 81 | Dibenzo[1,4,5]thiadiazepine: a hardly-known heterocyclic system with neuroprotective properties of potential usefulness in the treatment of neurodegenerative diseases. |
| AID548351 | Neuroprotective activity against rotenone and oligomycin-induced mitochondrial oxidative stress in human SH-SY5Y cells assessed as LDH release at 3 uM after 24 hrs using DCFH-DA fluorescent dye | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | Old phenothiazine and dibenzothiadiazepine derivatives for tomorrow's neuroprotective therapies against neurodegenerative diseases. |
| AID1242922 | Antioxidant activity in rat brain assessed as inhibition of MDA production at 10 uM by TBARS assay relative to control | 2015 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 25, Issue:18 | Phenolic 4-hydroxy and 3,5-dihydroxy derivatives of 3-phenoxyquinoxalin-2(1H)-one as potent aldose reductase inhibitors with antioxidant activity. |
| AID1083333 | Antiviral activity against Human coxsackievirus B4 infected human HeLa cells assessed as inhibition of virus-induced cytopathicity | 2011 | Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, , Volume: 20, Issue:2 | The novel amidocarbamate derivatives of ketoprofen: synthesis and biological activity. |
| AID1515594 | Antioxidant activity in rat hepatic microsomes assessed as reduction in ferrous salt/ascorbic acid-induced lipid peroxidation of membrane lipids by measuring TBARS level after 45 mins by spectrophotometric method | 2019 | ACS medicinal chemistry letters, Jan-10, Volume: 10, Issue:1 | Optimizing the Pharmacological Profile of New Bifunctional Antihyperlipidemic/Antioxidant Morpholine Derivatives. |
| AID1892584 | Antioxidant activity assessed as DPPH radical scavenging activity at 50 uM incubated for 30 mins by DPPH assay relative to control | 2022 | Journal of medicinal chemistry, 07-14, Volume: 65, Issue:13 | Novel Hydroxychalcone-Based Dual Inhibitors of Aldose Reductase and α-Glucosidase as Potential Therapeutic Agents against Diabetes Mellitus and Its Complications. |
| AID399080 | Antioxidant activity assessed as DPPH scavenging activity | 2005 | Journal of natural products, Nov, Volume: 68, Issue:11 | Free-radical-scavenging and xanthine oxidase inhibitory constituents from Stereospermum personatum. |
| AID683740 | Antioxidant activity assessed as Fe3+/ascorbic acid-induced hydroxyl radical scavenging activity at 0.1 mM after 30 mins | 2012 | Journal of medicinal chemistry, Jan-12, Volume: 55, Issue:1 | Α-aryl-N-alkyl nitrones, as potential agents for stroke treatment: synthesis, theoretical calculations, antioxidant, anti-inflammatory, neuroprotective, and brain-blood barrier permeability properties. |
| AID1392707 | Inhibition of HFIP-pretreated amyloid beta (1 to 42) (unknown origin) self-induced aggregation after 48 hrs by thioflavin T-based fluorometric assay | |||
| AID635124 | Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins | 2011 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 21, Issue:24 | Inhibitory activity of novel kojic acid derivative containing trolox moiety on melanogenesis. |
| AID382324 | Antioxidant activity assessed as inhibition of AAPH-induced peroxidation of DOPC liposome after 80 mins by thiocyanate method | 2008 | Bioorganic & medicinal chemistry, May-01, Volume: 16, Issue:9 | Carboxymethylated pyridoindole antioxidants as aldose reductase inhibitors: Synthesis, activity, partitioning, and molecular modeling. |
| AID1703579 | Antioxidant activity assessed as radical scavenging activity measured after 30 mins by microplate reader based DPPH assay | 2020 | European journal of medicinal chemistry, Oct-01, Volume: 203 | Discovery of novel berberine derivatives with balanced cholinesterase and prolyl oligopeptidase inhibition profile. |
| AID736838 | Antioxidant activity in mouse HT22 cells assessed as prevention of glutamate-induced GSH depletion at 25 uM | 2013 | Journal of medicinal chemistry, Feb-14, Volume: 56, Issue:3 | Structure-activity relationship study of vitamin k derivatives yields highly potent neuroprotective agents. |
| AID1581667 | Antioxidant activity assessed as increase in total ferric ion reducing activity at 150 uM using FeCl3.H2O and TPTZ incubated for 60 mins by FRAP assay relative to control | 2020 | European journal of medicinal chemistry, Feb-01, Volume: 187 | 1-Benzylpyrrolidine-3-amine-based BuChE inhibitors with anti-aggregating, antioxidant and metal-chelating properties as multifunctional agents against Alzheimer's disease. |
| AID1603219 | Antioxidant activity assessed as DPPH radical scavenging activity at 5 uM relative to control | 2019 | Bioorganic & medicinal chemistry, 04-15, Volume: 27, Issue:8 | Designing of acyl sulphonamide based quinoxalinones as multifunctional aldose reductase inhibitors. |
| AID1372031 | Antioxidant activity assessed as rate constant for singlet oxygen scavenging activity in ethanol-water (1:1 v/v) mixture using phosphorescence-based single-photon-counting method | 2017 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23 | Resveratrol analogues like piceatannol are potent antioxidants as quantitatively demonstrated through the high scavenging ability against reactive oxygen species and methyl radical. |
| AID639370 | Neuroprotective activity against H2O2-induced cell death in human SH-SY5Y cells assessed as LDH release at 10 uM incubated for 24 hrs before H2O2 challenge measured after 24 hrs relative to control | 2011 | European journal of medicinal chemistry, Jun, Volume: 46, Issue:6 | N-acylaminophenothiazines: neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease. |
| AID1326566 | Antioxidant activity in Salmonella typhimurium TA102 harboring hysG428 mutant assessed as inhibition of t-BuO2H-dependant mutant formation at 0.3 uM preincubated with compound followed by t-BuO2H addition after 48 hrs by Ames test | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Antioxidant and antitumor activity of trolox, trolox succinate, and α-tocopheryl succinate conjugates with nitroxides. |
| AID1330215 | Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins by spectrophotometric analysis | 2016 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 26, Issue:23 | Synthesis and biological assessment of novel N-(hydroxy/methoxy)alkyl β-enaminone curcuminoids. |
| AID310683 | Antioxidant activity assessed as DPPH free radical scavenging activity | 2007 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 17, Issue:24 | Synthesis and antioxidant properties of substituted 3-benzylidene-7-alkoxychroman-4-ones. |
| AID1249973 | Antioxidant activity assessed as DPPH radical scavenging activity at 0.3 to 10 uM incubated for 30 mins at 37 degC | 2015 | ACS medicinal chemistry letters, Aug-13, Volume: 6, Issue:8 | Highly Efficient Synthesis of 1,3-Dihydroxy-2-carboxycarbazole and Its Neuroprotective Effects. |
| AID402581 | Inhibition of H2O2-stimulated ROS production in human skin fibroblast assessed as DCF-fluorescence at 100 uM after 4 hrs by DCFH-DA assay relative to control | 2004 | Journal of natural products, Jun, Volume: 67, Issue:6 | Hyperjovinols A and B: Two new phloroglucinol derivatives from Hypericum jovis with antioxidant activity in cell cultures. |
| AID450087 | Antioxidant activity assessed as DMPD radical scavenging activity | 2009 | Bioorganic & medicinal chemistry, Sep-15, Volume: 17, Issue:18 | Antioxidant activity of 5,10-dihydroindeno[1,2-b]indoles containing substituents on dihydroindeno part. |
| AID1293542 | Neuroprotective activity against H2O2-induced neuronal cell death in human SH-SY5Y cells assessed as cell viability at 100 uM pretreated for 12 hrs followed by H2O2 addition measured after 3 hrs by MTT assay relative to control | 2016 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 26, Issue:6 | Neuroprotective oleanane triterpenes from the roots of Bupleurum chinense. |
| AID469405 | Neuroprotective activity against human SH-SY5Y cells assessed as protection reduction in H2O2-induced LDH release at 3 uM after 24 hrs | 2009 | Journal of medicinal chemistry, Nov-26, Volume: 52, Issue:22 | Neuroprotective and cholinergic properties of multifunctional glutamic acid derivatives for the treatment of Alzheimer's disease. |
| AID538078 | Antioxidant activity assessed as DPPH radical scavenging activity | 2010 | Bioorganic & medicinal chemistry, Dec-15, Volume: 18, Issue:24 | abeo-abietanes from Teucrium polium roots as protective factors against oxidative stress. |
| AID1480863 | Neuroprotective activity against glutamate-induced neuronal cell death in mouse HT22 cells assessed as intracellular reactive oxygen species level at 25 uM pretreated for 30 mins followed by glutamate challenge measured after 6 hrs by DCFH-DA probe based | 2017 | European journal of medicinal chemistry, Apr-21, Volume: 130 | Design, synthesis and evaluation of 2-arylethenyl-N-methylquinolinium derivatives as effective multifunctional agents for Alzheimer's disease treatment. |
| AID1348940 | Antioxidant activity assessed as DPPH radical scavenging activity at 30 uM after 20 mins by spectrophotometric method relative to control | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Trisubstituted barbiturates and thiobarbiturates: Synthesis and biological evaluation as xanthine oxidase inhibitors, antioxidants, antibacterial and anti-proliferative agents. |
| AID1294642 | Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins by microplate reader method | 2016 | European journal of medicinal chemistry, May-23, Volume: 114 | Novel benzylidenephenylpyrrolizinones with pleiotropic activities potentially useful in Alzheimer's disease treatment. |
| AID1493749 | Antioxidant activity assessed as total antioxidant capacity after 90 mins by phosphomolybdenum method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Design, synthesis and biochemical evaluation of novel multi-target inhibitors as potential anti-Parkinson agents. |
| AID1480874 | Neuroprotective activity against glutamate-induced neuronal cell death in mouse HT22 cells assessed as increase in glutathione level at 25 to 100 uM pretreated for 30 mins followed by glutamate challenge measured after 10 hrs | 2017 | European journal of medicinal chemistry, Apr-21, Volume: 130 | Design, synthesis and evaluation of 2-arylethenyl-N-methylquinolinium derivatives as effective multifunctional agents for Alzheimer's disease treatment. |
| AID310685 | Antioxidant activity at 100 ug by ferric reducing antioxidant power assay | 2007 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 17, Issue:24 | Synthesis and antioxidant properties of substituted 3-benzylidene-7-alkoxychroman-4-ones. |
| AID1324201 | Antioxidant activity assessed as superoxide radical scavenging activity measured every 30 secs for 6 mins in presence of superoxide generator pyrogallol | 2016 | Bioorganic & medicinal chemistry letters, 11-01, Volume: 26, Issue:21 | Synthesis and anti-inflammatory activity of paeonol analogues in the murine model of complete Freund's adjuvant induced arthritis. |
| AID218997 | Oxidation was assessed indirectly by measuring bovine serum albumin(BSA) thiol protection from the formation of thiobarbituric acid reactive substances (TBARs) by TBARs test at 500 uM | 2002 | Bioorganic & medicinal chemistry letters, Jan-21, Volume: 12, Issue:2 | New series of aryloxypropanolamines with both human beta(3)-adrenoceptor agonistic activity and free radical scavenging properties. |
| AID1581652 | Antioxidant activity assessed as ABTS radical scavenging activity at 150 uM measured after 5 mins by spectrophotometric assay relative to control | 2020 | European journal of medicinal chemistry, Feb-01, Volume: 187 | 1-Benzylpyrrolidine-3-amine-based BuChE inhibitors with anti-aggregating, antioxidant and metal-chelating properties as multifunctional agents against Alzheimer's disease. |
| AID668899 | Inhibition of nitrite level in LPS-induced mouse RAW264.7 cells at 50 uM by Griess assay relative to LPS treated control | 2011 | European journal of medicinal chemistry, Feb, Volume: 46, Issue:2 | Synthesis and effects of some novel tetrahydronaphthalene derivatives on proliferation and nitric oxide production in lipopolysaccharide activated Raw 264.7 macrophages. |
| AID1382552 | Antioxidant activity assessed as inhibition of DPPH radical generation after 30 mins | 2018 | European journal of medicinal chemistry, Mar-25, Volume: 148 | Synthesis and activity towards Alzheimer's disease in vitro: Tacrine, phenolic acid and ligustrazine hybrids. |
| AID1651392 | Neuroprotective activity against H2O2-induced cell death in human SH-SY5Y cells assessed as cell viability at 50 uM preincubated for 1 hr followed by H2O2 addition and measured after 4 hrs by CCK8 assay (Rvb = 61.14 +/- 1.05%) | 2020 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 30, Issue:4 | Isolation of triterpenoid saponins from Medicago sativa L. with neuroprotective activities. |
| AID1202555 | Antioxidant activity assessed as inhibition of ABTS free radical scavenging activity after 10 mins by spectrophotometry relative to control | 2015 | European journal of medicinal chemistry, , Volume: 96 | Design, synthesis and biological evaluation of quinazoline derivatives as anti-trypanosomatid and anti-plasmodial agents. |
| AID1713229 | Cytotoxicity against human SH-SY5Y cells assessed as cell viability at 6.3 uM measured after 2 hrs by MTT assay relative to control | 2016 | European journal of medicinal chemistry, Nov-10, Volume: 123 | Synthesis and in vitro, ex-vivo and in vivo activity of hybrid compounds linking a potent ROS and RNS scavenger activity with diverse substrates addressed to pass across the blood-brain barrier. |
| AID1348946 | Antiproliferative activity against NHDF at 30 uM after 72 hrs by MTT assay relative to control | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Trisubstituted barbiturates and thiobarbiturates: Synthesis and biological evaluation as xanthine oxidase inhibitors, antioxidants, antibacterial and anti-proliferative agents. |
| AID537007 | Antioxidant activity in mouse ScGT1 cells assessed as inhibition of ROS formation at 1 uM after 3 hrs by TBARS assay | 2010 | Journal of medicinal chemistry, Nov-25, Volume: 53, Issue:22 | Parallel synthesis, evaluation, and preliminary structure-activity relationship of 2,5-diamino-1,4-benzoquinones as a novel class of bivalent anti-prion compound. |
| AID1349623 | Antioxidant activity assessed as DPPH radical scavenging activity at 25 ug/ml after 1 hr | |||
| AID1610483 | Antioxidant activity assessed as decrease in ABTS radical cation scavenging activity every 1 min for 6 mins by UV-Vis spectrophotometric analysis | 2019 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 29, Issue:23 | Synthesis of 2-arylhydrazinylidene-3-oxo-4,4,4-trifluorobutanoic acids as new selective carboxylesterase inhibitors and radical scavengers. |
| AID227423 | In vitro percentage inhibition of glycation-induced fluorescence changes of BSA at 1 mM concentration | 2004 | Journal of medicinal chemistry, May-06, Volume: 47, Issue:10 | [1-(3,5-difluoro-4-hydroxyphenyl)-1H-pyrrol-3-yl]phenylmethanone as a bioisostere of a carboxylic acid aldose reductase inhibitor. |
| AID1300890 | Antioxidant activity of the compound after 90 mins by phosphomolybdenum assay | 2016 | European journal of medicinal chemistry, Jul-19, Volume: 117 | Novel 1,3-thiazolidin-4-one derivatives as promising anti-Candida agents endowed with anti-oxidant and chelating properties. |
| AID1152631 | Antioxidant activity assessed as DPPH free radical scavenging activity after 60 mins by spectrophotometric analysis | 2014 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 24, Issue:12 | Synthesis and radical scavenging activity of phenol-imidazole conjugates. |
| AID597264 | Antioxidant activity against AAPH-induced lipid peroxidation assessed as linoleic acid oxidation to diene hydroperoxide at 0.1 mM by UV-visible spectrophotometry | 2011 | Bioorganic & medicinal chemistry, May-01, Volume: 19, Issue:9 | Synthesis, in silico docking experiments of new 2-pyrrolidinone derivatives and study of their anti-inflammatory activity. |
| AID1713239 | Cytotoxicity against human SH-SY5Y cells assessed as cell viability at 1.6 uM measured after 24 hrs by MTT assay relative to control | 2016 | European journal of medicinal chemistry, Nov-10, Volume: 123 | Synthesis and in vitro, ex-vivo and in vivo activity of hybrid compounds linking a potent ROS and RNS scavenger activity with diverse substrates addressed to pass across the blood-brain barrier. |
| AID566095 | Antioxidant activity assessed as protection against APPH-induced linoleic acid lipid peroxidation 0.1 mM | 2011 | European journal of medicinal chemistry, Jan, Volume: 46, Issue:1 | One-pot microwave assisted synthesis under green chemistry conditions, antioxidant screening, and cytotoxicity assessments of benzimidazole Schiff bases and pyrimido[1,2-a]benzimidazol-3(4H)-ones. |
| AID248217 | In vitro inhibitory concentration against peroxynitrite (ONOO-): using pyrogallol red bleaching assay | 2005 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 15, Issue:12 | Nitrone derivatives of trolox as neuroprotective agents. |
| AID604217 | Antioxidant activity assessed as inhibition of ABTS free radicals after 30 mins by UV-visible spectrophotometer analysis relative to control | 2011 | Bioorganic & medicinal chemistry, Jul-01, Volume: 19, Issue:13 | Synthesis and evaluation of fluorescent heterocyclic aminoadamantanes as multifunctional neuroprotective agents. |
| AID218994 | Oxidation was assessed indirectly by measuring bovine serum albumin thiol protection by using Ellman''s test at 500 uM | 2002 | Bioorganic & medicinal chemistry letters, Jan-21, Volume: 12, Issue:2 | New series of aryloxypropanolamines with both human beta(3)-adrenoceptor agonistic activity and free radical scavenging properties. |
| AID1859608 | Antioxidant activity assessed as FRAP radical activity at 50 uM by FRAP assay | 2022 | European journal of medicinal chemistry, Aug-05, Volume: 238 | Halogen substituents enhance oxime nucleophilicity for reactivation of cholinesterases inhibited by nerve agents. |
| AID1702531 | Neuroprotective activity against H2O2-induced cell injury in rat PC12 cells assessed as cell viability preincubated for 2 hrs followed by H2O2 addition and measured after 24 hrs by MTT assay (Rvb = 53.8 %) | 2020 | European journal of medicinal chemistry, Feb-01, Volume: 187 | Apigenin-rivastigmine hybrids as multi-target-directed liagnds for the treatment of Alzheimer's disease. |
| AID548350 | Neuroprotective activity against H2O2-induced oxidative stress in human SH-SY5Y cells assessed as LDH release at 100 uM after 24 hrs by UV-vis spectroscopy | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | Old phenothiazine and dibenzothiadiazepine derivatives for tomorrow's neuroprotective therapies against neurodegenerative diseases. |
| AID676991 | Antioxidant activity assessed as inhibition of linoleic acid peroxidation at 100 uM by AAPH assay by UV spectrometry | 2012 | Bioorganic & medicinal chemistry, Sep-01, Volume: 20, Issue:17 | Synthesis of sulfur containing dihydro-pyrrolo derivatives and their biological evaluation as antioxidants. |
| AID668898 | Inhibition of nitrite level in LPS-induced mouse RAW264.7 cells at 5 uM by Griess assay relative to LPS treated control | 2011 | European journal of medicinal chemistry, Feb, Volume: 46, Issue:2 | Synthesis and effects of some novel tetrahydronaphthalene derivatives on proliferation and nitric oxide production in lipopolysaccharide activated Raw 264.7 macrophages. |
| AID1326575 | Cytotoxicity against mouse LMTK cells assessed as reduction in cell viability after 72 hrs by MTT assay | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Antioxidant and antitumor activity of trolox, trolox succinate, and α-tocopheryl succinate conjugates with nitroxides. |
| AID1326579 | Cytotoxicity against human HepG2 cells assessed as reduction in cell viability at 300 uM after 72 hrs by MTT assay | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Antioxidant and antitumor activity of trolox, trolox succinate, and α-tocopheryl succinate conjugates with nitroxides. |
| AID451368 | Antioxidant activity assessed as inhibition of H2O2-induced bovine serum albumin oxidation after 10 mins by spectrophotometry | 2009 | Bioorganic & medicinal chemistry, Sep-01, Volume: 17, Issue:17 | Antioxidant efficacy of iridoid and phenylethanoid glycosides from the medicinal plant Teucrium chamaedris in cell-free systems. |
| AID1256884 | Hepatotoxicity in human HepG2 cells assessed as cell viability at 512 uM after 24 hrs by MTT assay | 2015 | Journal of medicinal chemistry, Nov-25, Volume: 58, Issue:22 | Tacrine-Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity. |
| AID1320875 | Inhibition of human recombinant MAOB using p-tyramine as substrate incubated for 15 mins by fluorimetric method | 2016 | European journal of medicinal chemistry, Oct-04, Volume: 121 | New cinnamic - N-benzylpiperidine and cinnamic - N,N-dibenzyl(N-methyl)amine hybrids as Alzheimer-directed multitarget drugs with antioxidant, cholinergic, neuroprotective and neurogenic properties. |
| AID639460 | Neuroprotective activity against rotenone/oligomycin A-induced cell death in human SH-SY5Y cells assessed as LDH release at 3 mM after 24 hrs relative to control | 2011 | European journal of medicinal chemistry, Jun, Volume: 46, Issue:6 | N-acylaminophenothiazines: neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease. |
| AID1743177 | Antioxidant activity assessed as ABTS radical scavenging activity measured after 1 hr by UV-vis spectrophotometric method | 2020 | European journal of medicinal chemistry, Dec-15, Volume: 208 | Multiple biological active 4-aminopyrazoles containing trifluoromethyl and their 4-nitroso-precursors: Synthesis and evaluation. |
| AID1610482 | Inhibition of equine serum BuChE at 20 uM using butyrylcholine iodide as substrate preincubated for 10 mins followed by substrate addition by Ellman's method relative to control | 2019 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 29, Issue:23 | Synthesis of 2-arylhydrazinylidene-3-oxo-4,4,4-trifluorobutanoic acids as new selective carboxylesterase inhibitors and radical scavengers. |
| AID1713225 | Cytotoxicity against human SH-SY5Y cells assessed as cell viability at 100 uM measured after 2 hrs by MTT assay relative to control | 2016 | European journal of medicinal chemistry, Nov-10, Volume: 123 | Synthesis and in vitro, ex-vivo and in vivo activity of hybrid compounds linking a potent ROS and RNS scavenger activity with diverse substrates addressed to pass across the blood-brain barrier. |
| AID1465116 | Inhibition of equine serum BChE using butyrylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition by Ellman's method | 2017 | Bioorganic & medicinal chemistry, 11-01, Volume: 25, Issue:21 | 9-Substituted acridine derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors possessing antioxidant activity for Alzheimer's disease treatment. |
| AID380429 | Cytotoxicity against human BT549 cells upto 48 uM | 2006 | Journal of natural products, Mar, Volume: 69, Issue:3 | Schisandrene, a dibenzocyclooctadiene lignan from Schisandra chinensis: structure-antioxidant activity relationships of dibenzocyclooctadiene lignans. |
| AID264482 | Inhibition of hydrogen peroxide-induced death of mixed cortical cells of E15 Sprague-Dawley rat embryo at 10 uM | 2006 | Journal of medicinal chemistry, May-04, Volume: 49, Issue:9 | Fluorinated amphiphilic amino acid derivatives as antioxidant carriers: a new class of protective agents. |
| AID42807 | Inhibition of [Fe(2+)]/ascorbate-induced oxidation of bovine heart membranes(antioxidant BHMLO) | 1999 | Journal of medicinal chemistry, Jan-28, Volume: 42, Issue:2 | Novel esters and amides of nonsteroidal antiinflammatory carboxylic acids as antioxidants and antiproliferative agents. |
| AID619932 | Antioxidant activity assessed as inhibition of linoleic acid lipid peroxidation at 100 ug/ml measured after 12 hrs by ferric thiocynate method | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9 | Isoeugenol-based novel potent antioxidants: synthesis and reactivity. |
| AID1525516 | Antioxidant activity in human M17 cell lysate assessed as trolox equivalents of ABTS radical scavenging activity incubated up to 10 mins | 2019 | Journal of medicinal chemistry, 10-24, Volume: 62, Issue:20 | Rational Design of Multitarget-Directed Ligands: Strategies and Emerging Paradigms. |
| AID1713234 | Cytotoxicity against human SH-SY5Y cells assessed as cell viability at 50 uM measured after 24 hrs by MTT assay relative to control | 2016 | European journal of medicinal chemistry, Nov-10, Volume: 123 | Synthesis and in vitro, ex-vivo and in vivo activity of hybrid compounds linking a potent ROS and RNS scavenger activity with diverse substrates addressed to pass across the blood-brain barrier. |
| AID735814 | Antioxidant activity assessed as concentration required to 50 % ABTS radical scavenging activity absorbance at 734 nm | 2013 | Journal of natural products, Apr-26, Volume: 76, Issue:4 | Dorsamin-A's, glycerolipids carrying a dehydrophenylalanine ester moiety from the seed-eating larvae of the bruchid beetle Bruchidius dorsalis. |
| AID1418625 | Antioxidant activity assessed as ABTS radical scavenging activity incubated for 10 mins in dark | 2018 | Bioorganic & medicinal chemistry, 12-01, Volume: 26, Issue:22 | Resveratrol-maltol hybrids as multi-target-directed agents for Alzheimer's disease. |
| AID774816 | Antioxidant activity assessed as ABTS radical scavenging activity after 6 mins | 2013 | Bioorganic & medicinal chemistry, Nov-01, Volume: 21, Issue:21 | Synthesis and antioxidant activity of novel Mannich base of 1,3,4-oxadiazole derivatives possessing 1,4-benzodioxan. |
| AID1589465 | Antioxidant activity assessed as DPPH radical scavenging activity at 100 uM incubated for 30 mins under dark condition by spectrophotometry | 2019 | European journal of medicinal chemistry, Apr-15, Volume: 168 | Synthesis of new arylsulfonylspiroimidazolidine-2',4'-diones and study of their effect on stimulation of insulin release from MIN6 cell line, inhibition of human aldose reductase, sorbitol accumulations in various tissues and oxidative stress. |
| AID234581 | Inhibition time for 20 uM during peroxidation of methyl linoleate / DMVN in TBA /methanol medium at 40 degree Centigrade | 1993 | Journal of medicinal chemistry, May-14, Volume: 36, Issue:10 | Long-chain-substituted uric acid and 5,6-diaminouracil derivatives as novel agents against free radical processes: synthesis and in vitro activity. |
| AID1465115 | Inhibition of human erythrocyte AChE using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition by Ellman's method | 2017 | Bioorganic & medicinal chemistry, 11-01, Volume: 25, Issue:21 | 9-Substituted acridine derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors possessing antioxidant activity for Alzheimer's disease treatment. |
| AID264486 | Viability of rotifers against doxorubicin toxicity at 10 uM | 2006 | Journal of medicinal chemistry, May-04, Volume: 49, Issue:9 | Fluorinated amphiphilic amino acid derivatives as antioxidant carriers: a new class of protective agents. |
| AID1293536 | Neuroprotective activity against H2O2-induced neuronal cell death in human SH-SY5Y cells assessed as cell viability at 25 uM pretreated for 12 hrs followed by H2O2 addition measured after 3 hrs by MTT assay relative to control | 2016 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 26, Issue:6 | Neuroprotective oleanane triterpenes from the roots of Bupleurum chinense. |
| AID402580 | Inhibition of H2O2-stimulated ROS production in human skin fibroblast assessed as DCF-fluorescence at 10 uM after 4 hrs by DCFH-DA assay relative to control | 2004 | Journal of natural products, Jun, Volume: 67, Issue:6 | Hyperjovinols A and B: Two new phloroglucinol derivatives from Hypericum jovis with antioxidant activity in cell cultures. |
| AID633132 | Antioxidant activity in Wistar rat erythrocytes assessed as prolongation of initial inhibition period-lag phase of AAPH-induced hemolysis at 100 uM preincubated for 30 mins before induction measured up to 5 hrs by spectrophotometry | 2011 | Bioorganic & medicinal chemistry, Dec-01, Volume: 19, Issue:23 | (2-Benzyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-8-yl)-acetic acid: an aldose reductase inhibitor and antioxidant of zwitterionic nature. |
| AID426427 | In vivo antiinflammatory activity in Fisher 344 rat assessed as inhibition of carrageenan-induced paw edema at 0.01 mmol/kg, ip administered simultaneously with carrageenan measured after 3.5 hrs | 2009 | European journal of medicinal chemistry, Jul, Volume: 44, Issue:7 | Synthesis and evaluation of the antioxidant and anti-inflammatory activity of novel coumarin-3-aminoamides and their alpha-lipoic acid adducts. |
| AID180509 | Tested in vitro for the inhibition of iron-dependent lipid peroxidation against rat brain homogenates, by malondialdehyde (MDA) formation assay | 1992 | Journal of medicinal chemistry, Nov-13, Volume: 35, Issue:23 | 2-(Aminomethyl)chromans that inhibit iron-dependent lipid peroxidation and protect against central nervous system trauma and ischemia. |
| AID1256879 | Inhibition of human plasmatic BChE using butyrylthiocholine as substrate preincubated for 5 mins followed by substrate addition measured every 2 mins by Ellman's method | 2015 | Journal of medicinal chemistry, Nov-25, Volume: 58, Issue:22 | Tacrine-Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity. |
| AID1743181 | Antioxidant activity in human erythrocytes assessed as protection against AAPH-induced hemolysis at 400 uM preincubated for 20 mins followed by AAPH addition and measured after 2 hrs by spectrophotometric method relative to control | 2020 | European journal of medicinal chemistry, Dec-15, Volume: 208 | Multiple biological active 4-aminopyrazoles containing trifluoromethyl and their 4-nitroso-precursors: Synthesis and evaluation. |
| AID619940 | Antioxidant activity assessed as ferric to ferrous reduction at 10 ug/ml by FRAP assay | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9 | Isoeugenol-based novel potent antioxidants: synthesis and reactivity. |
| AID1357813 | Neuroprotective activity against H2O2-induced oxidative stress in human SH-SY5Y cells assessed as cell viability at 12.5 uM pre-incubated for 1 hr followed by H2O2 addition and measured after 4 hrs by MTT assay relative to control | 2018 | European journal of medicinal chemistry, May-10, Volume: 151 | Novel sarsasapogenin-triazolyl hybrids as potential anti-Alzheimer's agents: Design, synthesis and biological evaluation. |
| AID551408 | Antioxidant activity assessed as trolox equivalents of peroxyl radical scavenging activity by ORAC assay | 2011 | Bioorganic & medicinal chemistry, Jan-15, Volume: 19, Issue:2 | Synthesis, structure, theoretical and experimental in vitro antioxidant/pharmacological properties of α-aryl, N-alkyl nitrones, as potential agents for the treatment of cerebral ischemia. |
| AID1633206 | Antioxidant activity assessed as AAPH radical scavenging activity preincubated for 15 mins with fluorescein before AAPH addition and recorded every 2 mins for 160 mins by ORAC-FL assay | 2019 | European journal of medicinal chemistry, Apr-15, Volume: 168 | Design, synthesis, and evaluation of isoflavone analogs as multifunctional agents for the treatment of Alzheimer's disease. |
| AID1659477 | Antioxidant activity assessed as DPPH radical scavenging activity at 10 uM relative to control | 2020 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 30, Issue:9 | Novel quinolin-4(1H)-one derivatives as multi-effective aldose reductase inhibitors for treatment of diabetic complications: Synthesis, biological evaluation, and molecular modeling studies. |
| AID1592383 | Antioxidant activity assessed as DPPH radical scavenging activity measured after 45 mins by UV-Visible spectrophotometric based assay | |||
| AID736282 | Antioxidant activity assessed as reduction of Cu2+ to Cu+ measured as copper (I) level at 1 uM measured for 1 hr | 2013 | Journal of natural products, Apr-26, Volume: 76, Issue:4 | Scopoletin and scopolin isolated from Artemisia iwayomogi suppress differentiation of osteoclastic macrophage RAW 264.7 cells by scavenging reactive oxygen species. |
| AID1234558 | Antioxidant activity in rat liver microsomes assessed as reduction in iron-ascorbic acid-induced lipid peroxidase activity after 30 mins by TBARS assay | 2015 | Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15 | Synthesis of (2-amino)ethyl derivatives of quercetin 3-O-methyl ether and their antioxidant and neuroprotective effects. |
| AID184561 | Inhibition of [Fe(2+)]/ascorbate-induced lipid peroxidation at 10e-5 M in rat brain homogenate | 1994 | Journal of medicinal chemistry, Sep-02, Volume: 37, Issue:18 | Benzoselenazolinone derivatives designed to be glutathione peroxidase mimetics feature inhibition of cyclooxygenase/5-lipoxygenase pathways and anti-inflammatory activity. |
| AID1678098 | Antioxidant activity in rat brain homogenate assessed as inhibition of FeCl3/ascorbic acid-induced lipid peroxidation by measuring MDA level at 100 uM after 30 mins by thiobarbituric acid based spectrophotometric method relative to control | 2020 | Bioorganic & medicinal chemistry, 10-15, Volume: 28, Issue:20 | Dihydrobenzoxazinone derivatives as aldose reductase inhibitors with antioxidant activity. |
| AID1851307 | Antioxidant activity assessed as DPPH radical scavenging activity by DPPH assay | 2022 | Bioorganic & medicinal chemistry letters, 10-01, Volume: 73 | Biocatalytic synthesis and evaluation of antioxidant and antibacterial activities of hydroxyequols. |
| AID1326583 | Cytotoxicity against hamster AG17-1 cells assessed as reduction in cell viability at 300 uM after 72 hrs by MTT assay | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Antioxidant and antitumor activity of trolox, trolox succinate, and α-tocopheryl succinate conjugates with nitroxides. |
| AID1782120 | Antioxidant activity assessed as DPPH radical scavenging activity measured for 60 mins by spectrophotometric analysis | 2021 | Bioorganic & medicinal chemistry, 11-15, Volume: 50 | Investigation on the solid-phase synthesis of silybin prodrugs and their timed-release. |
| AID230361 | Reducing activity to scavenge 10 uM 1, 1-diphenylpicrylhydrazyl (DPPH) | 1993 | Journal of medicinal chemistry, May-14, Volume: 36, Issue:10 | Long-chain-substituted uric acid and 5,6-diaminouracil derivatives as novel agents against free radical processes: synthesis and in vitro activity. |
| AID1267383 | Antioxidant activity assessed as ABTS radical scavenging activity after 30 mins | 2016 | European journal of medicinal chemistry, Jan-01, Volume: 107 | Synthesis, pharmacological assessment, molecular modeling and in silico studies of fused tricyclic coumarin derivatives as a new family of multifunctional anti-Alzheimer agents. |
| AID1356533 | Antioxidant activity assessed as DPPH radical scavenging activity incubated for 10 mins under dark condition | 2018 | Journal of natural products, 08-24, Volume: 81, Issue:8 | A Bioactive Resveratrol Trimer from the Stem Bark of the Sri Lankan Endemic Plant Vateria copallifera. |
| AID1143539 | Antioxidant activity assessed as ABTS radical scavenging activity after 16 hrs by spectrophotometric analysis | 2014 | European journal of medicinal chemistry, Jun-23, Volume: 81 | Thiaflavan scavenges radicals and inhibits DNA oxidation: a story from the ferrocene modification. |
| AID1071850 | Antioxidant activity assessed as riboflavin/EDTA-induced superoxide anion radical scavenging activity by ESR spin trapping method relative to CYPMPO | 2014 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 24, Issue:5 | A multiple free-radical scavenging (MULTIS) study on the antioxidant capacity of a neuroprotective drug, edaravone as compared with uric acid, glutathione, and trolox. |
| AID1322939 | Antioxidant activity of the compound assessed as DPPH radical scavenging activity at 50 uM after 60 mins by spectrophotometric method | 2016 | European journal of medicinal chemistry, Oct-04, Volume: 121 | Donepezil-like multifunctional agents: Design, synthesis, molecular modeling and biological evaluation. |
| AID745286 | Antioxidant activity against AAPH-induced lipid peroxidation at 100 uM by UV spectrophotometry | 2013 | European journal of medicinal chemistry, May, Volume: 63 | Analysis of the antioxidant properties of differently substituted 2- and 3-indolyl carbohydrazides and related derivatives. |
| AID497111 | Antioxidant activity assessed as DPPH free radical scavenging activity after 1 hr | 2010 | Bioorganic & medicinal chemistry, Aug-01, Volume: 18, Issue:15 | Synthesis and biological evaluation of arylidene analogues of Meldrum's acid as a new class of antimalarial and antioxidant agents. |
| AID228563 | Krel expressed as Ki with respect to Ktrolox | 2001 | Bioorganic & medicinal chemistry letters, Sep-03, Volume: 11, Issue:17 | Imidazolopyrazinones as potential antioxidants. |
| AID257307 | Hydroxyl radical scavenging activity of Cudriana tricuspidata extracts | 2005 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 15, Issue:24 | Antioxidant and cytotoxic activities of xanthones from Cudrania tricuspidata. |
| AID196392 | Compound was evaluated for its inhibitory concentration against X/XO- induced oxidative neuronal damage in primary cultured rat cortical cells | 2002 | Bioorganic & medicinal chemistry letters, Sep-16, Volume: 12, Issue:18 | Synthesis and evaluation of 4-hydroxyphenylacetic acid amides and 4-hydroxycinnamamides as antioxidants. |
| AID257904 | Activity against hydrogen peroxide induced DNA damage in Jurkat T cells | 2006 | Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1 | Chroman/catechol hybrids: synthesis and evaluation of their activity against oxidative stress induced cellular damage. |
| AID459655 | Cytotoxicity against human Caco-2 cells assessed as plasma membrane damage at 60 uM after 7 days by LDH assay | 2010 | Bioorganic & medicinal chemistry, Mar-01, Volume: 18, Issue:5 | Exploring a synthetic organoselenium compound for antioxidant pharmacotherapy--toxicity and effects on ROS-production. |
| AID1194494 | Antioxidant activity assessed as ferric-reducing antioxidant power after 20 mins at 50 degC by UV spectrophotometry | 2015 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 25, Issue:8 | New septanoside and 20-hydroxyecdysone septanoside derivative from Atriplex portulacoides roots with preliminary biological activities. |
| AID469406 | Neuroprotective activity against human SH-SY5Y cells assessed as protection reduction in H2O2-induced LDH release at 10 uM after 24 hrs | 2009 | Journal of medicinal chemistry, Nov-26, Volume: 52, Issue:22 | Neuroprotective and cholinergic properties of multifunctional glutamic acid derivatives for the treatment of Alzheimer's disease. |
| AID619933 | Antioxidant activity assessed as inhibition of linoleic acid lipid peroxidation at 100 ug/ml measured after 18 hrs by ferric thiocynate method | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9 | Isoeugenol-based novel potent antioxidants: synthesis and reactivity. |
| AID1581661 | Antioxidant activity assessed as increase in total ferric ion reducing activity at 150 uM using FeCl3.H2O and TPTZ incubated for 5 mins by FRAP assay relative to control | 2020 | European journal of medicinal chemistry, Feb-01, Volume: 187 | 1-Benzylpyrrolidine-3-amine-based BuChE inhibitors with anti-aggregating, antioxidant and metal-chelating properties as multifunctional agents against Alzheimer's disease. |
| AID609920 | Antioxidant activity against AAPH-induced linoleic acid peroxidation at 100 uM by UV spectrophotometry analysis | 2011 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16 | Thrombin inhibitors with lipid peroxidation and lipoxygenase inhibitory activities. |
| AID427136 | Antioxidant activity assessed as ABTS radical scavenging activity after 6 mins by cation decolorization assay | 2009 | Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13 | p-Terphenyls from the fruiting bodies of Paxillus curtisii and their antioxidant properties. |
| AID471738 | Antioxidant activity assessed as inhibition of lipid peroxidation at 100 uM | 2009 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 19, Issue:22 | Synthesis of modified homo-N-nucleosides from the reactions of mesityl nitrile oxide with 9-allylpurines and their influence on lipid peroxidation and thrombin inhibition. |
| AID1730600 | Antioxidant activity assessed as ABTS radical scavenging activity incubated for 2 to 6 mins under dark condition | 2021 | European journal of medicinal chemistry, Mar-05, Volume: 213 | Design, synthesis, and biological evaluation of novel xanthone-alkylbenzylamine hybrids as multifunctional agents for the treatment of Alzheimer's disease. |
| AID639457 | Neuroprotective activity against rotenone/oligomycin A-induced cell death in human SH-SY5Y cells assessed as LDH release at 0.1 uM after 24 hrs relative to control | 2011 | European journal of medicinal chemistry, Jun, Volume: 46, Issue:6 | N-acylaminophenothiazines: neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease. |
| AID604210 | Antioxidant activity assessed as inhibition of DPPH free radicals at 0.01 mM after 30 mins by UV-visible spectrophotometer analysis relative to control | 2011 | Bioorganic & medicinal chemistry, Jul-01, Volume: 19, Issue:13 | Synthesis and evaluation of fluorescent heterocyclic aminoadamantanes as multifunctional neuroprotective agents. |
| AID1324202 | Antioxidant activity assessed as DPPH radical scavenging activity incubated for 30 mins in dark | 2016 | Bioorganic & medicinal chemistry letters, 11-01, Volume: 26, Issue:21 | Synthesis and anti-inflammatory activity of paeonol analogues in the murine model of complete Freund's adjuvant induced arthritis. |
| AID235284 | Free radical scavenging assessed as ABTS (2,2'-azinobis-(3-ethyl benz) thiazoline-6-sulfonic acid) color change | 2003 | Bioorganic & medicinal chemistry letters, Aug-18, Volume: 13, Issue:16 | Novel 3-O-acyl mesquitol analogues as free-radical scavengers and enzyme inhibitors: synthesis, biological evaluation and structure-activity relationship. |
| AID1428598 | Inhibition of HFIP-pretreated amyloid beta (1 to 42) (unknown origin) self-induced aggregation at 20 uM incubated for 24 hrs under dark condition by thioflavin-T based fluorometric assay relative to control | 2017 | European journal of medicinal chemistry, Feb-15, Volume: 127 | Synthesis and biological evaluation of deferiprone-resveratrol hybrids as antioxidants, Aβ |
| AID490419 | Cytoprotective activity against UV-induced LDL oxidation in HMEC1 cells at 10 uM after 6 hrs by MTT assay | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Synthesis and antioxidant activity evaluation of a syringic hydrazones family. |
| AID1293535 | Neuroprotective activity against H2O2-induced neuronal cell death in human SH-SY5Y cells assessed as cell viability at 50 uM pretreated for 12 hrs followed by H2O2 addition measured after 3 hrs by MTT assay relative to control | 2016 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 26, Issue:6 | Neuroprotective oleanane triterpenes from the roots of Bupleurum chinense. |
| AID1743178 | Antioxidant activity assessed as AAPH scavenging activity by measuring residual fluorescence at 10 uM measured at 1 min interval for 30 mins by ORAC fluorescein assay relative to control | 2020 | European journal of medicinal chemistry, Dec-15, Volume: 208 | Multiple biological active 4-aminopyrazoles containing trifluoromethyl and their 4-nitroso-precursors: Synthesis and evaluation. |
| AID536050 | Antioxidant activity assessed as protection against UV/H2O2-induced thymidine degradation in 12.5 mM phosphate buffer at 100 uM by competitive immuno-enzymatic assay | 2010 | Bioorganic & medicinal chemistry, Nov-15, Volume: 18, Issue:22 | Synthesis and antioxidant properties of pulvinic acids analogues. |
| AID469409 | Neuroprotective activity against rotenone/oligomycin A-treated human SH-SY5Y cells assessed as cytoprotection at 0.1 uM pretreated 24 hrs before rotenone/oligomycin A challenge | 2009 | Journal of medicinal chemistry, Nov-26, Volume: 52, Issue:22 | Neuroprotective and cholinergic properties of multifunctional glutamic acid derivatives for the treatment of Alzheimer's disease. |
| AID442293 | Inhibition of peroxynitrite-induced 3-nitrotyrosin formation by HPLC | 2010 | European journal of medicinal chemistry, Feb, Volume: 45, Issue:2 | Synthesis, anti-HCV, antioxidant, and peroxynitrite inhibitory activity of fused benzosuberone derivatives. |
| AID774814 | Antioxidant activity in KM mouse liver microsomes assessed as inhibition of lipid peroxidation after 60 mins | 2013 | Bioorganic & medicinal chemistry, Nov-01, Volume: 21, Issue:21 | Synthesis and antioxidant activity of novel Mannich base of 1,3,4-oxadiazole derivatives possessing 1,4-benzodioxan. |
| AID1474957 | Antioxidant activity assessed as ABTS radical scavenging activity at 2 mg/ml incubated for 2 hrs in dark by spectrophotometric analysis (Rvb = 1 to 9%) | 2017 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11 | Stereoselective synthesis of enantiopure N-substituted pyrrolidin-2,5-dione derivatives by 1,3-dipolar cycloaddition and assessment of their in vitro antioxidant and antibacterial activities. |
| AID490946 | Antioxidant activity assessed as DPPH radical scavenging activity at 100 uM after 60 mins | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Synthesis and biological screening of some novel amidocarbamate derivatives of ketoprofen. |
| AID1163382 | Antioxidant activity assessed as inhibition of lipid peroxidation at 100 uM by spectrophotometry | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Novel semicarbazides and ureas of primaquine with bulky aryl or hydroxyalkyl substituents: synthesis, cytostatic and antioxidative activity. |
| AID1424233 | Antioxidant activity assessed as hydroxyl radical scavenging activity by measuring rate constant using UV irradiation by ESR spin trapping method | 2017 | European journal of medicinal chemistry, Jun-16, Volume: 133 | Free radicals and polyphenols: The redox chemistry of neurodegenerative diseases. |
| AID295041 | Inhibition of Xanthine oxidase | 2007 | Bioorganic & medicinal chemistry letters, May-01, Volume: 17, Issue:9 | Quercinol, an anti-inflammatory chromene from the wood-rotting fungus Daedalea quercina (Oak Mazegill). |
| AID567049 | Antioxidant activity assessed as inhibition of heme protein-dependent lipid peroxidation at 1 mM | 2011 | European journal of medicinal chemistry, Jan, Volume: 46, Issue:1 | Design, synthesis and pharmacobiological evaluation of novel acrylic acid derivatives acting as lipoxygenase and cyclooxygenase-1 inhibitors with antioxidant and anti-inflammatory activities. |
| AID469407 | Neuroprotective activity against human SH-SY5Y cells assessed as protection reduction in H2O2-induced LDH release at 30 uM after 24 hrs | 2009 | Journal of medicinal chemistry, Nov-26, Volume: 52, Issue:22 | Neuroprotective and cholinergic properties of multifunctional glutamic acid derivatives for the treatment of Alzheimer's disease. |
| AID648156 | Antioxidant activity assessed as DPPH free radical scavenging activity by UV-Vis spectrophotometry | 2012 | European journal of medicinal chemistry, Apr, Volume: 50 | Novel molecular combination deriving from natural aminoacids and polyphenols: Design, synthesis and free-radical scavenging activities. |
| AID1406254 | Inhibition of human AChE using acetylthiocholine iodide as substrate assessed as residual activity at 10 uM preincubated for 5 mins followed by substrate addition and measured for 1 min by Ellman's assay relative to control | 2018 | European journal of medicinal chemistry, Aug-05, Volume: 156 | Multi-target-directed ligands for treating Alzheimer's disease: Butyrylcholinesterase inhibitors displaying antioxidant and neuroprotective activities. |
| AID264480 | Hydroxyl radical scavenging activity by ABTS competition assay per 30 mins at 1 umol/mL | 2006 | Journal of medicinal chemistry, May-04, Volume: 49, Issue:9 | Fluorinated amphiphilic amino acid derivatives as antioxidant carriers: a new class of protective agents. |
| AID1418624 | Inhibition of HFIP-pretreated amyloid beta (1 to 42) (unknown origin) self-induced aggregation at 20 uM after 24 hrs by thioflavin-T fluorescence assay relative to control | 2018 | Bioorganic & medicinal chemistry, 12-01, Volume: 26, Issue:22 | Resveratrol-maltol hybrids as multi-target-directed agents for Alzheimer's disease. |
| AID1474955 | Antioxidant activity assessed as ABTS radical scavenging activity at 0.5 mg/ml incubated for 2 hrs in dark by spectrophotometric analysis (Rvb = 1 to 9 %) | 2017 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11 | Stereoselective synthesis of enantiopure N-substituted pyrrolidin-2,5-dione derivatives by 1,3-dipolar cycloaddition and assessment of their in vitro antioxidant and antibacterial activities. |
| AID1729052 | Antioxidant activity in Swiss mouse brain cerebral tissue assessed as inhibition of SNP-induced lipid peroxidation by measuring TBARS level at 10 uM incubated for 1 hr relative to control | 2021 | European journal of medicinal chemistry, Mar-05, Volume: 213 | A greener protocol for the synthesis of phosphorochalcogenoates: Antioxidant and free radical scavenging activities. |
| AID1493966 | Antiproliferative activity against human A549 cells after 48 hrs by SRB assay | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | A green multicomponent synthesis of tocopherol analogues with antiproliferative activities. |
| AID1810883 | Antioxidant activity of compound assessed as trolox equivalent of AAPH radical scavenging activity preincubated for 15 mins followed by AAPH addition and measured every 2 mins for 90 mins by ORAC fluorescein assay | |||
| AID1589463 | Antioxidant activity assessed as DPPH radical scavenging activity at 10 uM incubated for 30 mins under dark condition by spectrophotometry | 2019 | European journal of medicinal chemistry, Apr-15, Volume: 168 | Synthesis of new arylsulfonylspiroimidazolidine-2',4'-diones and study of their effect on stimulation of insulin release from MIN6 cell line, inhibition of human aldose reductase, sorbitol accumulations in various tissues and oxidative stress. |
| AID1326570 | Cytotoxicity against human RPMI8226 cells assessed as reduction in cell viability after 72 hrs by MTT assay | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Antioxidant and antitumor activity of trolox, trolox succinate, and α-tocopheryl succinate conjugates with nitroxides. |
| AID1436063 | Neuroprotective activity against H2O2-induced damage in rat PC12 cells assessed as increase in cell viability at 100 uM pretreated for 2 hrs followed by H2O2 challenge measured after 24 hrs by MTT assay | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | Aurone Mannich base derivatives as promising multifunctional agents with acetylcholinesterase inhibition, anti-β-amyloid aggragation and neuroprotective properties for the treatment of Alzheimer's disease. |
| AID1480865 | Neuroprotective activity against glutamate-induced neuronal cell death in mouse HT22 cells assessed as intracellular reactive oxygen species level at 100 uM pretreated for 30 mins followed by glutamate challenge measured after 6 hrs by DCFH-DA probe based | 2017 | European journal of medicinal chemistry, Apr-21, Volume: 130 | Design, synthesis and evaluation of 2-arylethenyl-N-methylquinolinium derivatives as effective multifunctional agents for Alzheimer's disease treatment. |
| AID453103 | Antioxidant activity assessed as inhibition of peroxynitrite-mediated 3-nitrotyrosine formation by HPLC | 2009 | Bioorganic & medicinal chemistry, Dec-01, Volume: 17, Issue:23 | Synthesis, tautomerism, and antimicrobial, anti-HCV, anti-SSPE, antioxidant, and antitumor activities of arylazobenzosuberones. |
| AID1331319 | Antioxidant activity assessed as ABTS free radical scavenging activity at 10 uM | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2 | Synthesis and application of β-carbolines as novel multi-functional anti-Alzheimer's disease agents. |
| AID377070 | Antioxidant activity assessed as DPPH radical scavenging activity studied at DPPH to compound ratio of 5 | 2005 | Journal of natural products, Feb, Volume: 68, Issue:2 | Identification of radical scavenging compounds in Rhaponticum carthamoides by means of LC-DAD-SPE-NMR. |
| AID1511012 | Antioxidant activity assessed as H2O2 radical scavenging activity | 2019 | European journal of medicinal chemistry, Oct-15, Volume: 180 | Discovery of new potent dual sigma receptor/GluN2b ligands with antioxidant property as neuroprotective agents. |
| AID1515596 | Inhibition of SQS in rat liver microsomes assessed as reduction in [3H]FPP conversion to squalene preincubated for 10 mins followed by [3H]FPP addition and measured after 10 mins by scintillation counting method | 2019 | ACS medicinal chemistry letters, Jan-10, Volume: 10, Issue:1 | Optimizing the Pharmacological Profile of New Bifunctional Antihyperlipidemic/Antioxidant Morpholine Derivatives. |
| AID668900 | Cytotoxicity against mouse RAW264.7 cells at 5 uM by MTT assay | 2011 | European journal of medicinal chemistry, Feb, Volume: 46, Issue:2 | Synthesis and effects of some novel tetrahydronaphthalene derivatives on proliferation and nitric oxide production in lipopolysaccharide activated Raw 264.7 macrophages. |
| AID436306 | Antioxidant activity assessed as AAPH radical scavenging activity | 2008 | Journal of natural products, Nov, Volume: 71, Issue:11 | Monodictyochromes A and B, dimeric xanthone derivatives from the marine algicolous fungus Monodictys putredinis. |
| AID1083331 | Antiviral activity against Feline coronavirus infected feline kidney crandell cells assessed as inhibition of virus-induced cytopathicity | 2011 | Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, , Volume: 20, Issue:2 | The novel amidocarbamate derivatives of ketoprofen: synthesis and biological activity. |
| AID257306 | Superoxide radical scavenging activity of Cudriana tricuspidata extracts | 2005 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 15, Issue:24 | Antioxidant and cytotoxic activities of xanthones from Cudrania tricuspidata. |
| AID1318720 | Antioxidant activity assessed as DPPH free radical scavenging activity at 10 uM after 30 mins by UV-spectrophotometric method relative to control | 2016 | European journal of medicinal chemistry, Oct-04, Volume: 121 | A series of pyrido[2,3-b]pyrazin-3(4H)-one derivatives as aldose reductase inhibitors with antioxidant activity. |
| AID379313 | Antioxidant scavenging activity against 2,2'-azobis-amidinopropane-induced peroxyl radicals assessed as total oxyradical scavenging capacity | 2000 | Journal of natural products, Mar, Volume: 63, Issue:3 | Evaluation of the total peroxyl radical-scavenging capacity of flavonoids: structure-activity relationships. |
| AID1436862 | Antioxidant activity assessed as DPPH radical scavenging activity at 100 uM after 240 mins by UV spectrophotometer relative to control | 2017 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 27, Issue:4 | Synthesis and structure-activity relationship studies of phenolic hydroxyl derivatives based on quinoxalinone as aldose reductase inhibitors with antioxidant activity. |
| AID1300893 | Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins under dark conditions | 2016 | European journal of medicinal chemistry, Jul-19, Volume: 117 | Novel 1,3-thiazolidin-4-one derivatives as promising anti-Candida agents endowed with anti-oxidant and chelating properties. |
| AID490947 | Inhibition of soybean LOX at 100 uM | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Synthesis and biological screening of some novel amidocarbamate derivatives of ketoprofen. |
| AID196890 | Effect on in vitro myocardial electrical activity (arrhythmia score) at 5 uM | 2001 | Journal of medicinal chemistry, Nov-22, Volume: 44, Issue:24 | Novel potent inhibitors of lipid peroxidation with protective effects against reperfusion arrhythmias. |
| AID1581660 | Antioxidant activity assessed as increase in total ferric ion reducing activity at 75 uM using FeCl3.H2O and TPTZ incubated for 5 mins by FRAP assay relative to control | 2020 | European journal of medicinal chemistry, Feb-01, Volume: 187 | 1-Benzylpyrrolidine-3-amine-based BuChE inhibitors with anti-aggregating, antioxidant and metal-chelating properties as multifunctional agents against Alzheimer's disease. |
| AID333771 | Induction of HIF1beta protein in human T47D cells under normoxic condition at 100 uM after 4 hrs by Western blot analysis | 2004 | Journal of natural products, Dec, Volume: 67, Issue:12 | Hypoxia-inducible factor-1 activation by (-)-epicatechin gallate: potential adverse effects of cancer chemoprevention with high-dose green tea extracts. |
| AID1083329 | Antiviral activity against Unidentified Influenza A virus (H1N2) infected MDCK cells assessed as inhibition of virus-induced cytopathicity | 2011 | Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, , Volume: 20, Issue:2 | The novel amidocarbamate derivatives of ketoprofen: synthesis and biological activity. |
| AID286755 | Antioxidant activity assessed as DPPH reducing activity at 0.5 mM after 20 mins | 2007 | Journal of medicinal chemistry, May-17, Volume: 50, Issue:10 | Design and synthesis of novel quinolinone-3-aminoamides and their alpha-lipoic acid adducts as antioxidant and anti-inflammatory agents. |
| AID196224 | Relative efficacy gives an indication of the percent of viable cells (Rat cerebellar granule cells) at the maximal efficacious concentration of 77.8 uM | 2000 | Journal of medicinal chemistry, Jul-27, Volume: 43, Issue:15 | 3,5-Disubstituted-4-hydroxyphenyls linked to 3-hydroxy-2-methyl-4(1H)-pyridinone: potent inhibitors of lipid peroxidation and cell toxicity. |
| AID1755234 | Antagonist activity at human H3 receptor by TR-FRET assay | |||
| AID1277565 | Antioxidant activity assessed as suppression of H2O2/cobalt2+-mediated hydroxyl radical formation by luminol-based fluorescence assay | 2016 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 26, Issue:4 | Synthesis and biological evaluation of novel orally available 1-phenyl-6-aminouracils containing dimethyldihydrobenzofuranol structure for the treatment of allergic skin diseases. |
| AID1071845 | Antioxidant activity assessed as H2O2-induced hydroxyl radical scavenging activity by ESR spin trapping method | 2014 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 24, Issue:5 | A multiple free-radical scavenging (MULTIS) study on the antioxidant capacity of a neuroprotective drug, edaravone as compared with uric acid, glutathione, and trolox. |
| AID1327544 | Antioxidant activity assessed as inhibition of AAPH-induced peroxyl radical generation measured as trolox equivalent at 10 uM preincubated for 30 mins followed by AAPH addition measured evey 60 secs for 60 cycles by ORAC-FL assay | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Multifunctional diamine AGE/ALE inhibitors with potential therapeutical properties against Alzheimer's disease. |
| AID1434538 | Antioxidant activity assessed as inhibition of ferrous chloride-induced lipid peroxidation at 50 uM preincubated for 24 hrs followed by ferrous chloride addition relative to control | 2017 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 27, Issue:3 | New antiprotozoal agents: Synthesis and biological evaluation of different 4-(7-chloroquinolin-4-yl) piperazin-1-yl)pyrrolidin-2-yl)methanone derivatives. |
| AID736290 | Ratio of trolox EC50 to compound EC50 for ABTS free radical scavenging activity | 2013 | Journal of natural products, Apr-26, Volume: 76, Issue:4 | Antioxidant and anti-inflammatory meroterpenoids from the brown alga Cystoseira usneoides. |
| AID1318719 | Antioxidant activity assessed as DPPH free radical scavenging activity at 50 uM after 30 mins by UV-spectrophotometric method relative to control | 2016 | European journal of medicinal chemistry, Oct-04, Volume: 121 | A series of pyrido[2,3-b]pyrazin-3(4H)-one derivatives as aldose reductase inhibitors with antioxidant activity. |
| AID1071848 | Antioxidant activity assessed as t-butylhyroperoxide-induced alkylperoxyl radical scavenging activity by ESR spin trapping method relative to CYPMPO | 2014 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 24, Issue:5 | A multiple free-radical scavenging (MULTIS) study on the antioxidant capacity of a neuroprotective drug, edaravone as compared with uric acid, glutathione, and trolox. |
| AID1728603 | Antioxidant activity assessed as H2O2 radical scavenging activity in pH 7.4 buffer at 1 to 30 uM measured after 24 hrs by quantichrom-peroxide assay kit based method | 2021 | European journal of medicinal chemistry, Feb-15, Volume: 212 | ROS-responsive and multifunctional anti-Alzheimer prodrugs: Tacrine-ibuprofen hybrids via a phenyl boronate linker. |
| AID1325288 | Antioxidant activity assessed as ferric ion reducing activity by measuring Fe2+ levels using fe3+-TPTZ at 1500 ug/ml after 30 mins by FRAP assay | 2016 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 26, Issue:22 | Antioxidant and anti-inflammatory neolignans from the seeds of hawthorn. |
| AID1238057 | Antioxidant activity assessed as DPPH radical scavenging activity incubated for 30 mins under dark conditions | 2015 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 25, Issue:16 | Nitric oxide inhibitory activity and antioxidant evaluations of 2-benzoyl-6-benzylidenecyclohexanone analogs, a novel series of curcuminoid and diarylpentanoid derivatives. |
| AID1372029 | Antioxidant activity assessed as relative scavenging rate constant for photolysis-induced super-oxide anion scavenging activity by measuring Kaox/Kst ratio using CYPMPO spin trap by ESR spectroscopic method | 2017 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23 | Resveratrol analogues like piceatannol are potent antioxidants as quantitatively demonstrated through the high scavenging ability against reactive oxygen species and methyl radical. |
| AID1083330 | Antiviral activity against Unidentified Influenza A virus (H1N2) infected MDCK cells assessed as inhibition of virus-induced cytopathicity | 2011 | Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, , Volume: 20, Issue:2 | The novel amidocarbamate derivatives of ketoprofen: synthesis and biological activity. |
| AID289270 | Reduction of hydroxyl radical activity at 1 mM in presence of 33 nM DMSO | 2007 | Bioorganic & medicinal chemistry, Sep-01, Volume: 15, Issue:17 | Synthesis and pharmacochemical evaluation of novel aryl-acetic acid inhibitors of lipoxygenase, antioxidants, and anti-inflammatory agents. |
| AID1071841 | Antioxidant activity assessed as DMSO/H2O2-induced methyl radical scavenging activity by ESR spin trapping method | 2014 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 24, Issue:5 | A multiple free-radical scavenging (MULTIS) study on the antioxidant capacity of a neuroprotective drug, edaravone as compared with uric acid, glutathione, and trolox. |
| AID1257005 | Antioxidant activity assessed as DPPH scavenging activity at 10 to 60 ug/ml after 30 mins | 2015 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 25, Issue:23 | Synthesis of donepezil-based multifunctional agents for the treatment of Alzheimer's disease. |
| AID1071746 | Antioxidant activity against AAPH-induced lipid peroxidation assessed as inhibition of conjugated diene hydroperoxide production at 100 uM | 2014 | European journal of medicinal chemistry, Mar-03, Volume: 74 | Toxicological and pharmacological evaluation, antioxidant, ADMET and molecular modeling of selected racemic chromenotacrines {11-amino-12-aryl-8,9,10,12-tetrahydro-7H-chromeno[2,3-b]quinolin-3-ols} for the potential prevention and treatment of Alzheimer's |
| AID1651393 | Neuroprotective activity against H2O2-induced cell death in human SH-SY5Y cells assessed as cell viability at 100 uM preincubated for 1 hr followed by H2O2 addition and measured after 4 hrs by CCK8 assay (Rvb = 61.14 +/- 1.05%) | 2020 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 30, Issue:4 | Isolation of triterpenoid saponins from Medicago sativa L. with neuroprotective activities. |
| AID1581662 | Antioxidant activity assessed as increase in total ferric ion reducing activity at 30 uM using FeCl3.H2O and TPTZ incubated for 30 mins by FRAP assay relative to control | 2020 | European journal of medicinal chemistry, Feb-01, Volume: 187 | 1-Benzylpyrrolidine-3-amine-based BuChE inhibitors with anti-aggregating, antioxidant and metal-chelating properties as multifunctional agents against Alzheimer's disease. |
| AID1392706 | Inhibition of HFIP-pretreated amyloid beta (1 to 42) (unknown origin) self-induced aggregation at 10 uM after 48 hrs by thioflavin T-based fluorometric assay relative to control | |||
| AID1581655 | Antioxidant activity assessed as ABTS radical scavenging activity at 150 uM measured after 30 mins by spectrophotometric assay relative to control | 2020 | European journal of medicinal chemistry, Feb-01, Volume: 187 | 1-Benzylpyrrolidine-3-amine-based BuChE inhibitors with anti-aggregating, antioxidant and metal-chelating properties as multifunctional agents against Alzheimer's disease. |
| AID639459 | Neuroprotective activity against rotenone/oligomycin A-induced cell death in human SH-SY5Y cells assessed as LDH release at 1 uM after 24 hrs relative to control | 2011 | European journal of medicinal chemistry, Jun, Volume: 46, Issue:6 | N-acylaminophenothiazines: neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease. |
| AID1264039 | Antioxidant activity in human SH-SY5Y cells assessed as reduction of xanthine oxidase-mediated superoxide generation preincubated for 1 hr followed by xanthine oxidase challenge for 1 hr by MitoSOX staining-based fluorescence analysis | 2015 | Journal of medicinal chemistry, Nov-25, Volume: 58, Issue:22 | Orally Bioavailable Metal Chelators and Radical Scavengers: Multifunctional Antioxidants for the Coadjutant Treatment of Neurodegenerative Diseases. |
| AID1493750 | Antioxidant activity assessed as ferric ion reducing activity using using Fe3+-TPTZ after 30 mins by FRAP assay | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Design, synthesis and biochemical evaluation of novel multi-target inhibitors as potential anti-Parkinson agents. |
| AID1357815 | Neuroprotective activity against H2O2-induced oxidative stress in human SH-SY5Y cells assessed as cell viability at 50 uM pre-incubated for 1 hr followed by H2O2 addition and measured after 4 hrs by MTT assay relative to control | 2018 | European journal of medicinal chemistry, May-10, Volume: 151 | Novel sarsasapogenin-triazolyl hybrids as potential anti-Alzheimer's agents: Design, synthesis and biological evaluation. |
| AID1534715 | Antioxidant activity assessed as ABTS radical cation scavenging activity by measuring trolox equivalents after 150 mins | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Synthesis and evaluation of isoprenylation-resveratrol dimer derivatives against Alzheimer's disease. |
| AID1702443 | Neuroprotective activity against H2O2-induced cell injury in rat PC-12 cells assessed as increase in cell viability causing decrease in LDH content preincubated for 2 hrs followed by H2O2 addition and measured after 24 hrs by LDH assay | 2020 | European journal of medicinal chemistry, Feb-01, Volume: 187 | Apigenin-rivastigmine hybrids as multi-target-directed liagnds for the treatment of Alzheimer's disease. |
| AID295042 | Inhibition of COX1 | 2007 | Bioorganic & medicinal chemistry letters, May-01, Volume: 17, Issue:9 | Quercinol, an anti-inflammatory chromene from the wood-rotting fungus Daedalea quercina (Oak Mazegill). |
| AID286757 | Antioxidant activity assessed as DMSO hydroxyl radical scavenging activity at 0.1 mM | 2007 | Journal of medicinal chemistry, May-17, Volume: 50, Issue:10 | Design and synthesis of novel quinolinone-3-aminoamides and their alpha-lipoic acid adducts as antioxidant and anti-inflammatory agents. |
| AID378807 | Antioxidant activity assessed as inhibition of hydroxyl radical generation by fluorescence spectroscopy | 2006 | Journal of natural products, Oct, Volume: 69, Issue:10 | Antioxidative phenolics from the fresh leaves of Ternstroemia japonica. |
| AID1075986 | Neuroprotective activity against Abeta1-42 peptide-induced neurotoxicity in rat C6 cells assessed as cell viability at 100 uM after 24 hrs by MTT assay | 2014 | European journal of medicinal chemistry, Mar-21, Volume: 75 | Synthesis, biological evaluation and molecular modeling study of novel tacrine-carbazole hybrids as potential multifunctional agents for the treatment of Alzheimer's disease. |
| AID619943 | Antioxidant activity assessed as ferric to ferrous reduction activity at 40 ug/ml by FRAP assay | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9 | Isoeugenol-based novel potent antioxidants: synthesis and reactivity. |
| AID452852 | Antioxidant activity assessed as hydroxyl radical scavenging activity at 100 uM | 2009 | Bioorganic & medicinal chemistry, Dec-01, Volume: 17, Issue:23 | Natural and synthetic 2'-hydroxy-chalcones and aurones: synthesis, characterization and evaluation of the antioxidant and soybean lipoxygenase inhibitory activity. |
| AID1594788 | Neuroprotective activity in human SH-SY5Y cells assessed as reduction in H2O2-induced cell damage by measuring cell viability level at 50 uM by MTT assay (Rvb = 67.95%) | 2019 | Journal of natural products, 06-28, Volume: 82, Issue:6 | Guaiane-Type Sesquiterpenoids from the Roots of Daphne genkwa and Evaluation of Their Neuroprotective Effects. |
| AID1713233 | Cytotoxicity against human SH-SY5Y cells assessed as cell viability at 100 uM measured after 24 hrs by MTT assay relative to control | 2016 | European journal of medicinal chemistry, Nov-10, Volume: 123 | Synthesis and in vitro, ex-vivo and in vivo activity of hybrid compounds linking a potent ROS and RNS scavenger activity with diverse substrates addressed to pass across the blood-brain barrier. |
| AID1167300 | Antioxidant activity assessed as DPPH radical scavenging activity incubated at room temperature for 20 mins by UV-visible spectrophotometry | 2014 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 24, Issue:21 | Design, synthesis and exploring the quantitative structure-activity relationship of some antioxidant flavonoid analogues. |
| AID1264036 | Neuroprotective activity against Fenton reagent-induced ROS generation-stimulated cytotoxicity in human SH-SY5Y cells assessed as cell viability at 1 mM after 2 hrs by MTS assay | 2015 | Journal of medicinal chemistry, Nov-25, Volume: 58, Issue:22 | Orally Bioavailable Metal Chelators and Radical Scavengers: Multifunctional Antioxidants for the Coadjutant Treatment of Neurodegenerative Diseases. |
| AID277125 | Cytotoxicity against microglial cells at 10 uM | 2006 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 16, Issue:24 | Total synthesis and biological evaluation of viscolin, a 1,3-diphenylpropane as a novel potent anti-inflammatory agent. |
| AID1575654 | Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins under dark condition by spectrophotometric analysis | 2019 | MedChemComm, May-01, Volume: 10, Issue:5 | Synthesis of novel vanillin derivatives: novel multi-targeted scaffold ligands against Alzheimer's disease. |
| AID1315210 | Antioxidant activity of the compound assessed as inhibition of fenton reaction-induced DNA strand cleavage of plasmid pcDNA Hismyc B4 after 1 hr by ethidium bromide staining-based agarose gel electrophoresis | 2016 | European journal of medicinal chemistry, Oct-04, Volume: 121 | Multi-target screening mines hesperidin as a multi-potent inhibitor: Implication in Alzheimer's disease therapeutics. |
| AID639365 | Neuroprotective activity against H2O2-induced cell death in human SH-SY5Y cells assessed as LDH release at 1 uM incubated for 24 hrs before H2O2 challenge measured after 24 hrs relative to control | 2011 | European journal of medicinal chemistry, Jun, Volume: 46, Issue:6 | N-acylaminophenothiazines: neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease. |
| AID1428599 | Inhibition of HFIP-pretreated amyloid beta (1 to 42) (unknown origin) self-induced aggregation incubated for 24 hrs under dark condition by thioflavin-T based fluorometric assay | 2017 | European journal of medicinal chemistry, Feb-15, Volume: 127 | Synthesis and biological evaluation of deferiprone-resveratrol hybrids as antioxidants, Aβ |
| AID458693 | Cytotoxicity against HEK293 cells assessed as cell death at 60 uM after 7 days by LDH assay | 2010 | Bioorganic & medicinal chemistry, Mar-01, Volume: 18, Issue:5 | Exploring a synthetic organoselenium compound for antioxidant pharmacotherapy--toxicity and effects on ROS-production. |
| AID1592382 | Cytotoxicity against human HepG2 cells assessed as cell metabolic activity at 10 uM incubated for 48 hrs by resazurin assay relative to control | |||
| AID1892588 | Antioxidant activity in rat brain homogenate assessed as inhibition of lipid peroxidation by measuring MDA concentration at 5 uM by TBARS assay relative to control | 2022 | Journal of medicinal chemistry, 07-14, Volume: 65, Issue:13 | Novel Hydroxychalcone-Based Dual Inhibitors of Aldose Reductase and α-Glucosidase as Potential Therapeutic Agents against Diabetes Mellitus and Its Complications. |
| AID625358 | Antioxidant activity assessed as DPPH free radical scavenging activity at 100 uM | 2011 | European journal of medicinal chemistry, Dec, Volume: 46, Issue:12 | Synthesis and biological evaluation of (2,5-dihydro-1H-pyrrol-1-yl)-2H-chromen-2-ones as free radical scavengers. |
| AID1493752 | Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Design, synthesis and biochemical evaluation of novel multi-target inhibitors as potential anti-Parkinson agents. |
| AID619939 | Antioxidant activity assessed as superoxide radical scavenging activity after 40 mins by Zhishen's method | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9 | Isoeugenol-based novel potent antioxidants: synthesis and reactivity. |
| AID1729059 | Antioxidant activity in Swiss mouse brain cerebral tissue assessed as inhibition of sodium azide-induced reactive species production by measuring fluorescence unit at 10 uM by DCHF-DA dye based spectrofluorimetric method (Rvb = 139 +/- 26.8 U) | 2021 | European journal of medicinal chemistry, Mar-05, Volume: 213 | A greener protocol for the synthesis of phosphorochalcogenoates: Antioxidant and free radical scavenging activities. |
| AID1300891 | Antioxidant activity of the compound after 30 mins by FRAP assay | 2016 | European journal of medicinal chemistry, Jul-19, Volume: 117 | Novel 1,3-thiazolidin-4-one derivatives as promising anti-Candida agents endowed with anti-oxidant and chelating properties. |
| AID1083342 | Antiviral activity against Punta Toro virus infected Hela cells assessed as inhibition of virus-induced cytopathicity | 2011 | Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, , Volume: 20, Issue:2 | The novel amidocarbamate derivatives of ketoprofen: synthesis and biological activity. |
| AID1424253 | Antioxidant activity assessed as effect on linolenic acid autooxidation in presence of 0.015 M SDS based micellar systems | 2017 | European journal of medicinal chemistry, Jun-16, Volume: 133 | Free radicals and polyphenols: The redox chemistry of neurodegenerative diseases. |
| AID1480869 | Neuroprotective activity against glutamate-induced neuronal cell death in mouse HT22 cells assessed as intracellular reactive oxygen species level at 25 uM pretreated for 30 mins followed by glutamate challenge after 10 hrs by DCFH-DA probe based FACS ana | 2017 | European journal of medicinal chemistry, Apr-21, Volume: 130 | Design, synthesis and evaluation of 2-arylethenyl-N-methylquinolinium derivatives as effective multifunctional agents for Alzheimer's disease treatment. |
| AID1872744 | Antioxidant activity assessed as DPPH radical scavenging activity measured after 30 mins | 2022 | European journal of medicinal chemistry, Apr-05, Volume: 233 | Resveratrol-based compounds and neurodegeneration: Recent insight in multitarget therapy. |
| AID736486 | Antioxidant activity assessed as inhibition of ABTS radical formation for 15 mins by spectrophotometric analysis | 2013 | European journal of medicinal chemistry, Apr, Volume: 62 | Exploring nature profits: development of novel and potent lipophilic antioxidants based on galloyl-cinnamic hybrids. |
| AID537161 | Antioxidant activity assessed as DPPH radical scavenging activity after 270 mins by least-square analysis | 2010 | Journal of medicinal chemistry, Nov-11, Volume: 53, Issue:21 | A diverse series of substituted benzenesulfonamides as aldose reductase inhibitors with antioxidant activity: design, synthesis, and in vitro activity. |
| AID1306600 | Cytotoxicity against HMEC1 assessed as cell viability at 10 uM after 24 hrs by MTT assay in absence of oxidized LDL | 2016 | Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16 | Synthesis and evaluation of antioxidant phenolic diaryl hydrazones as potent antiangiogenic agents in atherosclerosis. |
| AID1418623 | Inhibition of HFIP-pretreated amyloid beta (1 to 42) (unknown origin) self-induced aggregation after 24 hrs by thioflavin-T fluorescence assay | 2018 | Bioorganic & medicinal chemistry, 12-01, Volume: 26, Issue:22 | Resveratrol-maltol hybrids as multi-target-directed agents for Alzheimer's disease. |
| AID1331320 | Antioxidant activity assessed as DPPH radical scavenging activity at 10 uM | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2 | Synthesis and application of β-carbolines as novel multi-functional anti-Alzheimer's disease agents. |
| AID1480870 | Neuroprotective activity against glutamate-induced neuronal cell death in mouse HT22 cells assessed as intracellular reactive oxygen species level at 50 uM pretreated for 30 mins followed by glutamate challenge after 10 hrs by DCFH-DA probe based FACS ana | 2017 | European journal of medicinal chemistry, Apr-21, Volume: 130 | Design, synthesis and evaluation of 2-arylethenyl-N-methylquinolinium derivatives as effective multifunctional agents for Alzheimer's disease treatment. |
| AID1293785 | Antioxidant activity assessed as ABTS free radical scavenging activity after 1 min by spectrophotometry | 2016 | Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9 | 2-Phenylbenzofuran derivatives as butyrylcholinesterase inhibitors: Synthesis, biological activity and molecular modeling. |
| AID1242921 | Antioxidant activity assessed as DPPH radical scavenging activity at 50 uM after 240 mins by spectrophotometric analysis relative to control | 2015 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 25, Issue:18 | Phenolic 4-hydroxy and 3,5-dihydroxy derivatives of 3-phenoxyquinoxalin-2(1H)-one as potent aldose reductase inhibitors with antioxidant activity. |
| AID1326578 | Cytotoxicity against human RPMI8226 cells assessed as reduction in cell viability at 300 uM after 72 hrs by MTT assay | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Antioxidant and antitumor activity of trolox, trolox succinate, and α-tocopheryl succinate conjugates with nitroxides. |
| AID1083336 | Antiviral activity against Human parainfluenza virus 3 infected Vero cells assessed as inhibition of virus-induced cytopathicity | 2011 | Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, , Volume: 20, Issue:2 | The novel amidocarbamate derivatives of ketoprofen: synthesis and biological activity. |
| AID227421 | In vitro percentage inhibition of formation of DNPH-reactive carbonyl groups in BSA exposed to fructose at 1 mM concentration | 2004 | Journal of medicinal chemistry, May-06, Volume: 47, Issue:10 | [1-(3,5-difluoro-4-hydroxyphenyl)-1H-pyrrol-3-yl]phenylmethanone as a bioisostere of a carboxylic acid aldose reductase inhibitor. |
| AID469410 | Neuroprotective activity against rotenone/oligomycin A-treated human SH-SY5Y cells assessed as cytoprotection at 0.3 uM pretreated 24 hrs before rotenone/oligomycin A challenge | 2009 | Journal of medicinal chemistry, Nov-26, Volume: 52, Issue:22 | Neuroprotective and cholinergic properties of multifunctional glutamic acid derivatives for the treatment of Alzheimer's disease. |
| AID1264025 | Neuroprotective activity against Fenton reagent-induced ROS generation in human ARPE19 cells assessed as increase in GSH level at 1 mM after 2 hrs by DTNB method | 2015 | Journal of medicinal chemistry, Nov-25, Volume: 58, Issue:22 | Orally Bioavailable Metal Chelators and Radical Scavengers: Multifunctional Antioxidants for the Coadjutant Treatment of Neurodegenerative Diseases. |
| AID1424252 | Antioxidant activity assessed as effect on linolenic acid autooxidation in presence of 0.5 M SDS based micellar systems | 2017 | European journal of medicinal chemistry, Jun-16, Volume: 133 | Free radicals and polyphenols: The redox chemistry of neurodegenerative diseases. |
| AID1143748 | Neuroprotective activity in human SH-SY5Y cells assessed as protection against rotenone-oligomycin-induced toxicity at 1 uM preincubated for 24 hrs before rotenone-oligomycin addition measured after 24 hrs by lactate dehydrogenase release assay | 2014 | European journal of medicinal chemistry, Jun-23, Volume: 81 | Dibenzo[1,4,5]thiadiazepine: a hardly-known heterocyclic system with neuroprotective properties of potential usefulness in the treatment of neurodegenerative diseases. |
| AID427666 | Antioxidant activity assessed as superoxide anion radical scavenging activity by spectrophotometry | 2009 | Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13 | Potential antioxidants and tyrosinase inhibitors from synthetic polyphenolic deoxybenzoins. |
| AID1228330 | Antioxidant activity assessed as inhibition of AAPH-induced crocin oxidation at 5 to 500 uM in lipophilic medium containing linoleic acid by crocin bleaching assay | 2015 | Journal of natural products, May-22, Volume: 78, Issue:5 | Interaction of α-Hexylcinnamaldehyde with a Biomembrane Model: A Possible MDR Reversal Mechanism. |
| AID1083348 | Antioxidant activity assessed as inhibition of AAPH-induced lipid peroxidation at 1 X 10'-5 M | 2011 | Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, , Volume: 20, Issue:2 | The novel amidocarbamate derivatives of ketoprofen: synthesis and biological activity. |
| AID1846106 | Antioxidant activity assessed as trolox equivalent of ABTS radical cation scavenging activity measured for 15 mins by spectrophotometeric analysis | 2021 | European journal of medicinal chemistry, Apr-05, Volume: 215 | A review on ferulic acid and analogs based scaffolds for the management of Alzheimer's disease. |
| AID1083332 | Antiviral activity against Respiratory syncytial virus infected human HeLa cells assessed as inhibition of virus-induced cytopathicity | 2011 | Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, , Volume: 20, Issue:2 | The novel amidocarbamate derivatives of ketoprofen: synthesis and biological activity. |
| AID1581663 | Antioxidant activity assessed as increase in total ferric ion reducing activity at 75 uM using FeCl3.H2O and TPTZ incubated for 30 mins by FRAP assay relative to control | 2020 | European journal of medicinal chemistry, Feb-01, Volume: 187 | 1-Benzylpyrrolidine-3-amine-based BuChE inhibitors with anti-aggregating, antioxidant and metal-chelating properties as multifunctional agents against Alzheimer's disease. |
| AID625354 | Antioxidant activity assessed as hydroxyl radical scavenging activity at 100 uM after 30 mins | 2011 | European journal of medicinal chemistry, Dec, Volume: 46, Issue:12 | Synthesis and biological evaluation of (2,5-dihydro-1H-pyrrol-1-yl)-2H-chromen-2-ones as free radical scavengers. |
| AID333770 | Induction of HIF1alpha protein in human T47D cells under normoxic condition at 100 uM after 4 hrs by Western blot analysis | 2004 | Journal of natural products, Dec, Volume: 67, Issue:12 | Hypoxia-inducible factor-1 activation by (-)-epicatechin gallate: potential adverse effects of cancer chemoprevention with high-dose green tea extracts. |
| AID1306598 | Antiangiogenic activity in HMEC1 assessed as inhibition of oxidized LDL induced tube formation measured as residual tube at 10 uM after 18 hrs by calcein staining based fluorescence microscopy | 2016 | Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16 | Synthesis and evaluation of antioxidant phenolic diaryl hydrazones as potent antiangiogenic agents in atherosclerosis. |
| AID1377506 | Antioxidant activity assessed as ABTS radical scavenging activity after 30 mins | 2017 | European journal of medicinal chemistry, Sep-29, Volume: 138 | A novel structural class of coumarin-chalcone fibrates as PPARα/γ agonists with potent antioxidant activities: Design, synthesis, biological evaluation and molecular docking studies. |
| AID344045 | Antioxidant activity assessed as ABTS radical scavenging activity after 12 hrs | 2008 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 18, Issue:14 | Cyathuscavins A, B, and C, new free radical scavengers with DNA protection activity from the Basidiomycete Cyathus stercoreus. |
| AID320331 | Antioxidant activity in human MCF7 cells by FRAP test | 2008 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 18, Issue:3 | Synthesis and protective effects of coumarin derivatives against oxidative stress induced by doxorubicin. |
| AID537162 | Antioxidant activity assessed as ratio of IC50 for DPPH radical scavenging activity to concentration of DPPH | 2010 | Journal of medicinal chemistry, Nov-11, Volume: 53, Issue:21 | A diverse series of substituted benzenesulfonamides as aldose reductase inhibitors with antioxidant activity: design, synthesis, and in vitro activity. |
| AID1581653 | Antioxidant activity assessed as ABTS radical scavenging activity at 30 uM measured after 30 mins by spectrophotometric assay relative to control | 2020 | European journal of medicinal chemistry, Feb-01, Volume: 187 | 1-Benzylpyrrolidine-3-amine-based BuChE inhibitors with anti-aggregating, antioxidant and metal-chelating properties as multifunctional agents against Alzheimer's disease. |
| AID462445 | Antioxidant activity against AAPH-induced lipid peroxidation in unilamellar DOPC liposomes after 80 mins by thiocyanate reagent method | 2010 | Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6 | Design and synthesis of novel series of pyrrole based chemotypes and their evaluation as selective aldose reductase inhibitors. A case of bioisosterism between a carboxylic acid moiety and that of a tetrazole. |
| AID1743180 | Antioxidant activity in human erythrocytes assessed as protection against AAPH-induced hemolysis at 50 uM preincubated for 20 mins followed by AAPH addition and measured after 2 hrs by spectrophotometric method relative to control | 2020 | European journal of medicinal chemistry, Dec-15, Volume: 208 | Multiple biological active 4-aminopyrazoles containing trifluoromethyl and their 4-nitroso-precursors: Synthesis and evaluation. |
| AID310684 | Antioxidant activity in Wistar rat brain assessed as inhibition of lipid peroxidation | 2007 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 17, Issue:24 | Synthesis and antioxidant properties of substituted 3-benzylidene-7-alkoxychroman-4-ones. |
| AID1435200 | Antioxidant activity assessed as ABTS radical scavenging activity after 1 min | 2017 | Bioorganic & medicinal chemistry, 03-01, Volume: 25, Issue:5 | New insights into highly potent tyrosinase inhibitors based on 3-heteroarylcoumarins: Anti-melanogenesis and antioxidant activities, and computational molecular modeling studies. |
| AID548352 | Neuroprotective activity against rotenone and oligomycin-induced mitochondrial oxidative stress in human SH-SY5Y cells assessed as LDH release at 10 uM after 24 hrs using DCFH-DA fluorescent dye | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | Old phenothiazine and dibenzothiadiazepine derivatives for tomorrow's neuroprotective therapies against neurodegenerative diseases. |
| AID1248049 | Antioxidant activity assessed as inhibition of AAPH-induced lipid peroxidation after 3 hrs by TBA-MDA test | 2015 | Bioorganic & medicinal chemistry, Oct-01, Volume: 23, Issue:19 | Synthesis, electronic properties, antioxidant and antibacterial activity of some new benzimidazoles. |
| AID1385652 | Neuroprotective activity against glutamate-induced cell death in mouse HT22 cells assessed as cell viability at 12.5 uM pretreated for 2 hrs followed by glutamate-challenge and measured after 20 hrs by MTT assay (Rvb = 23 +/- 3.57%) | 2018 | Journal of natural products, 08-24, Volume: 81, Issue:8 | Targeted Isolation of Neuroprotective Dicoumaroyl Neolignans and Lignans from Sageretia theezans Using in Silico Molecular Network Annotation Propagation-Based Dereplication. |
| AID1743176 | Antioxidant activity assessed as trolox equivalent of ABTS radical scavenging activity measured after 1 hr by UV-vis spectrophotometric method | 2020 | European journal of medicinal chemistry, Dec-15, Volume: 208 | Multiple biological active 4-aminopyrazoles containing trifluoromethyl and their 4-nitroso-precursors: Synthesis and evaluation. |
| AID447535 | Antioxidant activity assessed as DPPH free radical scavenging activity by UV spectroscopic method | 2009 | Bioorganic & medicinal chemistry, Jul-15, Volume: 17, Issue:14 | Synthesis, antioxidant properties and radioprotective effects of new benzothiazoles and thiadiazoles. |
| AID1071851 | Antioxidant activity assessed as H2O2-induced hydroxyl radical scavenging activity by ESR spin trapping method relative to CYPMPO | 2014 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 24, Issue:5 | A multiple free-radical scavenging (MULTIS) study on the antioxidant capacity of a neuroprotective drug, edaravone as compared with uric acid, glutathione, and trolox. |
| AID1406256 | Selectivity ratio of IC50 for human AChE to IC50 for human BChE | 2018 | European journal of medicinal chemistry, Aug-05, Volume: 156 | Multi-target-directed ligands for treating Alzheimer's disease: Butyrylcholinesterase inhibitors displaying antioxidant and neuroprotective activities. |
| AID1436861 | Antioxidant activity assessed as DPPH radical scavenging activity at 50 uM after 240 mins by UV spectrophotometer relative to control | 2017 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 27, Issue:4 | Synthesis and structure-activity relationship studies of phenolic hydroxyl derivatives based on quinoxalinone as aldose reductase inhibitors with antioxidant activity. |
| AID427134 | Protection against ferrous and hydrogen peroxide-induced single strand breakage of pBR322 DNA at 50 uM after 30 mins using ethium bromide staining | 2009 | Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13 | p-Terphenyls from the fruiting bodies of Paxillus curtisii and their antioxidant properties. |
| AID1564984 | Antioxidant activity in human SH-SY5Y cells assessed as inhibition of t-BuOOH-induced intracellular oxidative stress by measuring ROS level at 100 uM preincubated for 24 hrs followed by t-BuOOH addition and measured after 30 mins by DCFH-DA dye-based fluo | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Novel multi target-directed ligands targeting 5-HT |
| AID1382555 | Protection against CoCl2-induced damage in rat PC12 cells assessed as cell viability at 10 uM preincubated for 36 hrs followed by CoCl2 addition measured after 12 hrs by MTT assay (Rvb = 51.2%) | 2018 | European journal of medicinal chemistry, Mar-25, Volume: 148 | Synthesis and activity towards Alzheimer's disease in vitro: Tacrine, phenolic acid and ligustrazine hybrids. |
| AID1762405 | Inhibition of equine serum BuChE using butyrylcholine iodide as substrate preincubated for 10 mins followed by substrate addition by Ellman's method | 2021 | European journal of medicinal chemistry, Jun-05, Volume: 218 | Novel potent bifunctional carboxylesterase inhibitors based on a polyfluoroalkyl-2-imino-1,3-dione scaffold. |
| AID548354 | Neuroprotective activity against H2O2-induced oxidative stress in human SH-SY5Y cells assessed as LDH release at 100 uM after 24 hrs by UV-vis spectroscopy in presence of calcium channel blocker nimodipine | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | Old phenothiazine and dibenzothiadiazepine derivatives for tomorrow's neuroprotective therapies against neurodegenerative diseases. |
| AID598279 | Antioxidant activity assessed as DPPH free radical scavenging activity after 30 mins | 2011 | European journal of medicinal chemistry, May, Volume: 46, Issue:5 | Synthesis of chromone carboxamide derivatives with antioxidative and calpain inhibitory properties. |
| AID218993 | Oxidation was assessed indirectly by measuring bovine serum albumin thiol protection by using Ellman''s test at 1 mM | 2002 | Bioorganic & medicinal chemistry letters, Jan-21, Volume: 12, Issue:2 | New series of aryloxypropanolamines with both human beta(3)-adrenoceptor agonistic activity and free radical scavenging properties. |
| AID1678473 | Antioxidant activity assessed as ferric ion reducing activity using FeCl3.H2O and TPTZ incubated for 30 mins by FRAP assay | 2020 | ACS medicinal chemistry letters, Nov-12, Volume: 11, Issue:11 | Covalent Bridging of Corilagin Improves Antiferroptosis Activity: Comparison with 1,3,6-Tri- |
| AID1194493 | Antioxidant activity assessed as ABTS radical scavenging activity incubated for 6 mins | 2015 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 25, Issue:8 | New septanoside and 20-hydroxyecdysone septanoside derivative from Atriplex portulacoides roots with preliminary biological activities. |
| AID1327543 | Reactive carbonyl species trapping activity of compound assessed as MDA adduct formation at 10 mM preincubated for 24 hrs with MDA measured after 1 hr by LCMS analysis | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Multifunctional diamine AGE/ALE inhibitors with potential therapeutical properties against Alzheimer's disease. |
| AID264481 | Radical reducing potency by ABTS cation radical reduction assay per 30 mins at 1 umol/mL | 2006 | Journal of medicinal chemistry, May-04, Volume: 49, Issue:9 | Fluorinated amphiphilic amino acid derivatives as antioxidant carriers: a new class of protective agents. |
| AID1179728 | Antioxidant activity assessed as reduction in mouse CRL2181 cells-mediated human LDL oxidation by measuring TBARS level at 10 uM after 18 hrs | 2014 | Bioorganic & medicinal chemistry, Aug-01, Volume: 22, Issue:15 | Synthesis, antioxidant and cytoprotective evaluation of potential antiatherogenic phenolic hydrazones. A structure-activity relationship insight. |
| AID1678474 | Antioxidant activity assessed as DPPH free radical scavenging activity after 5 mins by microplate reader based assay | 2020 | ACS medicinal chemistry letters, Nov-12, Volume: 11, Issue:11 | Covalent Bridging of Corilagin Improves Antiferroptosis Activity: Comparison with 1,3,6-Tri- |
| AID1257020 | Antioxidant activity assessed as inhibition of AAPH-induced linoleic acid lipid peroxidation at 100 uM | 2015 | Bioorganic & medicinal chemistry, Nov-15, Volume: 23, Issue:22 | Synthesis and biological evaluation of new C-10 substituted dithranol pleiotropic hybrids. |
| AID295043 | Inhibition of COX2 | 2007 | Bioorganic & medicinal chemistry letters, May-01, Volume: 17, Issue:9 | Quercinol, an anti-inflammatory chromene from the wood-rotting fungus Daedalea quercina (Oak Mazegill). |
| AID1238058 | Antioxidant activity incubated at 50 degC for 20 mins by FRAP assay | 2015 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 25, Issue:16 | Nitric oxide inhibitory activity and antioxidant evaluations of 2-benzoyl-6-benzylidenecyclohexanone analogs, a novel series of curcuminoid and diarylpentanoid derivatives. |
| AID1603216 | Antioxidant activity assessed as DPPH radical scavenging activity at 100 uM relative to control | 2019 | Bioorganic & medicinal chemistry, 04-15, Volume: 27, Issue:8 | Designing of acyl sulphonamide based quinoxalinones as multifunctional aldose reductase inhibitors. |
| AID1655202 | Antioxidant activity in pH 7.4 PBS assessed as H2O2 radical scavenging activity | 2020 | ACS medicinal chemistry letters, May-14, Volume: 11, Issue:5 | Synthesis, Cytotoxicity Evaluation, and Computational Insights of Novel 1,4-Diazepane-Based Sigma Ligands. |
| AID619937 | Antioxidant activity assessed as residual DPPH radical scavenging activity after 30 mins by spectrophotometric analysis | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9 | Isoeugenol-based novel potent antioxidants: synthesis and reactivity. |
| AID1493967 | Antiproliferative activity against human HBL100 cells after 48 hrs by SRB assay | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | A green multicomponent synthesis of tocopherol analogues with antiproliferative activities. |
| AID469412 | Neuroprotective activity against rotenone/oligomycin A-treated human SH-SY5Y cells assessed as cytoprotection at 3 uM pretreated 24 hrs before rotenone/oligomycin A challenge | 2009 | Journal of medicinal chemistry, Nov-26, Volume: 52, Issue:22 | Neuroprotective and cholinergic properties of multifunctional glutamic acid derivatives for the treatment of Alzheimer's disease. |
| AID248216 | In vitro inhibitory concentration against Total peroxyl radical-trapping antioxidant parameter(TRAP) | 2005 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 15, Issue:12 | Nitrone derivatives of trolox as neuroprotective agents. |
| AID1762407 | Antioxidant activity assessed as trolox equivalent of ABTS radical cation scavenging activity incubated for 24 hrs by UV-Vis spectrophotometric analysis | 2021 | European journal of medicinal chemistry, Jun-05, Volume: 218 | Novel potent bifunctional carboxylesterase inhibitors based on a polyfluoroalkyl-2-imino-1,3-dione scaffold. |
| AID1810909 | Inhibition of human BChE using butyrylthiocholine iodide as substrate at 10 uM incubated for 20 mins followed by substrate addition by Ellman's method | |||
| AID1331318 | Antioxidant activity assessed as inhibition of peroxyl radical-induced oxidation at 10 uM by ORAC assay | 2017 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 27, Issue:2 | Synthesis and application of β-carbolines as novel multi-functional anti-Alzheimer's disease agents. |
| AID1326564 | Genotoxicity in Salmonella typhimurium TA102 harboring hysG428 mutant assessed as frequency of reversion from histidine auxotrophy to prototrophy at 30 mM after 48 hrs by Ames test (Rvb = 209 +/- 10 No _unit) | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Antioxidant and antitumor activity of trolox, trolox succinate, and α-tocopheryl succinate conjugates with nitroxides. |
| AID1592384 | Antioxidant activity assessed as ABTS radical scavenging activity measured after 15 mins by UV-Visible spectrophotometric based assay | |||
| AID1083353 | Antioxidant activity assessed as DPPH radical scavenging activity at 5 X 10'-5 M after 20 min | 2011 | Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, , Volume: 20, Issue:2 | The novel amidocarbamate derivatives of ketoprofen: synthesis and biological activity. |
| AID1436102 | Antioxidant activity assessed as DPPH radical scavenging activity at 50 uM relative to control | 2017 | European journal of medicinal chemistry, Jan-27, Volume: 126 | 2,4-Disubstituted quinazolines as amyloid-β aggregation inhibitors with dual cholinesterase inhibition and antioxidant properties: Development and structure-activity relationship (SAR) studies. |
| AID234579 | Inhibition time for 20 uM during peroxidation of liposomal suspension of dilinoleoylphosphatidylcholine (DPLC) indicated by DMVN at 40 degree Centigrade | 1993 | Journal of medicinal chemistry, May-14, Volume: 36, Issue:10 | Long-chain-substituted uric acid and 5,6-diaminouracil derivatives as novel agents against free radical processes: synthesis and in vitro activity. |
| AID1311888 | Antioxidant activity against human SH-SY5Y cells assessed as amyloid beta (1 to 42)-induced ROS production preincubated for 1 day prior H2O2 treatment at 1.25 uM by DCFH-DA-based fluorescence analysis relative to control | 2016 | Bioorganic & medicinal chemistry, 09-15, Volume: 24, Issue:18 | Design, synthesis, and evaluation of Trolox-conjugated amyloid-β C-terminal peptides for therapeutic intervention in an in vitro model of Alzheimer's disease. |
| AID1678102 | Antioxidant activity assessed as DPPH radical scavenging activity at 1 uM relative to control | 2020 | Bioorganic & medicinal chemistry, 10-15, Volume: 28, Issue:20 | Dihydrobenzoxazinone derivatives as aldose reductase inhibitors with antioxidant activity. |
| AID451361 | Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins by spectrophotometry | 2009 | Bioorganic & medicinal chemistry, Sep-01, Volume: 17, Issue:17 | Antioxidant efficacy of iridoid and phenylethanoid glycosides from the medicinal plant Teucrium chamaedris in cell-free systems. |
| AID295045 | Inhibition of horseradish peroxidase | 2007 | Bioorganic & medicinal chemistry letters, May-01, Volume: 17, Issue:9 | Quercinol, an anti-inflammatory chromene from the wood-rotting fungus Daedalea quercina (Oak Mazegill). |
| AID1325289 | Antioxidant activity assessed as ferric ion reducing activity by measuring Fe2+ levels using fe3+-TPTZ at 3000 ug/ml after 30 mins by FRAP assay | 2016 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 26, Issue:22 | Antioxidant and anti-inflammatory neolignans from the seeds of hawthorn. |
| AID457183 | Antioxidant activity assessed as superoxide radical scavenging activity by chemiluminescence assay | 2010 | Bioorganic & medicinal chemistry, Jan-15, Volume: 18, Issue:2 | Quiquelignan A-H, eight new lignoids from the rattan palm Calamus quiquesetinervius and their antiradical, anti-inflammatory and antiplatelet aggregation activities. |
| AID1348945 | Antiproliferative activity against human MCF7 cells at 30 uM after 72 hrs by MTT assay relative to control | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Trisubstituted barbiturates and thiobarbiturates: Synthesis and biological evaluation as xanthine oxidase inhibitors, antioxidants, antibacterial and anti-proliferative agents. |
| AID639461 | Antioxidant activity in human SH-SY5Y cells assessed as sequestering of rotenone/oligomycin A-induced mitochondrial free radicals at 0.3 uM after 120 mins by DCFH-DA assay | 2011 | European journal of medicinal chemistry, Jun, Volume: 46, Issue:6 | N-acylaminophenothiazines: neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease. |
| AID628336 | Antioxidant activity in rat hepatic microsomes assessed as inhibition of lipid peroxidation by spectrophotometric analysis | 2011 | Journal of medicinal chemistry, Aug-11, Volume: 54, Issue:15 | Novel benzoxazine and benzothiazine derivatives as multifunctional antihyperlipidemic agents. |
| AID1326567 | Antioxidant activity in Salmonella typhimurium TA102 harboring hysG428 mutant assessed as inhibition of t-BuO2H-dependant mutant formation at 3 uM preincubated with compound followed by t-BuO2H addition after 48 hrs by Ames test | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Antioxidant and antitumor activity of trolox, trolox succinate, and α-tocopheryl succinate conjugates with nitroxides. |
| AID490421 | Cytotoxicity against HMEC1 cells after 6 hrs by MTT assay | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Synthesis and antioxidant activity evaluation of a syringic hydrazones family. |
| AID1678100 | Antioxidant activity assessed as DPPH radical scavenging activity at 10 uM relative to control | 2020 | Bioorganic & medicinal chemistry, 10-15, Volume: 28, Issue:20 | Dihydrobenzoxazinone derivatives as aldose reductase inhibitors with antioxidant activity. |
| AID762877 | Antioxidant activity assessed as trolox equivalents of peroxyl radical scavenging activity at 0.3 to 2 uM preincubated for 15 mins by ORAC assay relative to control | 2013 | Journal of medicinal chemistry, Aug-08, Volume: 56, Issue:15 | Synthesis and electrochemical and biological studies of novel coumarin-chalcone hybrid compounds. |
| AID450085 | Antioxidant activity assessed as DPPH radical scavenging activity | 2009 | Bioorganic & medicinal chemistry, Sep-15, Volume: 17, Issue:18 | Antioxidant activity of 5,10-dihydroindeno[1,2-b]indoles containing substituents on dihydroindeno part. |
| AID1581666 | Antioxidant activity assessed as increase in total ferric ion reducing activity at 75 uM using FeCl3.H2O and TPTZ incubated for 60 mins by FRAP assay relative to control | 2020 | European journal of medicinal chemistry, Feb-01, Volume: 187 | 1-Benzylpyrrolidine-3-amine-based BuChE inhibitors with anti-aggregating, antioxidant and metal-chelating properties as multifunctional agents against Alzheimer's disease. |
| AID1325284 | Antioxidant activity assessed as DPPH radical scavenging activity incubated in dark for 30 mins | 2016 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 26, Issue:22 | Antioxidant and anti-inflammatory neolignans from the seeds of hawthorn. |
| AID401040 | Antioxidant activity against cupric ion-induced lipid peroxidation in human LDL by TBA assay | 1998 | Journal of natural products, May, Volume: 61, Issue:5 | Isolation, identification, and antioxidant activity of three stilbene glucosides newly extracted from vitis vinifera cell cultures |
| AID490945 | Antioxidant activity assessed as DPPH radical scavenging activity at 100 uM after 20 mins | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Synthesis and biological screening of some novel amidocarbamate derivatives of ketoprofen. |
| AID286754 | Antioxidant activity assessed as DPPH reducing activity at 0.1 mM after 60 mins | 2007 | Journal of medicinal chemistry, May-17, Volume: 50, Issue:10 | Design and synthesis of novel quinolinone-3-aminoamides and their alpha-lipoic acid adducts as antioxidant and anti-inflammatory agents. |
| AID1659476 | Antioxidant activity assessed as DPPH radical scavenging activity at 50 uM relative to control | 2020 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 30, Issue:9 | Novel quinolin-4(1H)-one derivatives as multi-effective aldose reductase inhibitors for treatment of diabetic complications: Synthesis, biological evaluation, and molecular modeling studies. |
| AID295044 | Inhibition of 3alphaHSD | 2007 | Bioorganic & medicinal chemistry letters, May-01, Volume: 17, Issue:9 | Quercinol, an anti-inflammatory chromene from the wood-rotting fungus Daedalea quercina (Oak Mazegill). |
| AID1918880 | Antioxidant activity assessed as inhibition of ABTS radical scavenging activity measured upto 6 mins | 2022 | Journal of natural products, 12-23, Volume: 85, Issue:12 | Bioactive Arylnaphthalide Lignans from |
| AID469413 | Neuroprotective activity against human SH-SY5Y cells assessed as cytoprotection at 0.1 uM coincubated with rotenone/oligomycin A measured after 24 hrs | 2009 | Journal of medicinal chemistry, Nov-26, Volume: 52, Issue:22 | Neuroprotective and cholinergic properties of multifunctional glutamic acid derivatives for the treatment of Alzheimer's disease. |
| AID1264040 | Antioxidant activity in human ARPE19 cells assessed as reduction of xanthine oxidase-mediated superoxide generation preincubated for 1 hr followed by xanthine oxidase challenge for 1 hr by MitoSOX staining-based fluorescence analysis | 2015 | Journal of medicinal chemistry, Nov-25, Volume: 58, Issue:22 | Orally Bioavailable Metal Chelators and Radical Scavengers: Multifunctional Antioxidants for the Coadjutant Treatment of Neurodegenerative Diseases. |
| AID1327545 | Metal chelating activity of compound assessed as compound-Cu2+ complex formation at 200 uM after 10 mins in presence of CuSO4.5H2O by complexometric indicator murexide based UV-Vis spectrophotometric analysis | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Multifunctional diamine AGE/ALE inhibitors with potential therapeutical properties against Alzheimer's disease. |
| AID1704055 | Antioxidant activity assessed as radical scavenging activity measured after 30 mins by DPPH assay | 2020 | European journal of medicinal chemistry, Oct-15, Volume: 204 | Synthesis, inhibitory activity and in silico docking of dual COX/5-LOX inhibitors with quinone and resorcinol core. |
| AID1179763 | Ratio of compound IC50 to trolox IC50 for DPPH radical scavenging activity after 30 mins by spectrophotometry | 2014 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15 | Phenylpropanoid acid esters from Korean propolis and their antioxidant activities. |
| AID1372030 | Antioxidant activity assessed as relative scavenging rate constant for photolysis-induced singlet oxygen scavenging activity by measuring Kaox/Kst ratio using 4-HO-TEMP spin trap by ESR spectroscopic method | 2017 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23 | Resveratrol analogues like piceatannol are potent antioxidants as quantitatively demonstrated through the high scavenging ability against reactive oxygen species and methyl radical. |
| AID1256117 | Metal chelating activity assessed as inhibition of Fe2+-ferrozine complex formation after 10 mins | 2015 | Journal of medicinal chemistry, Nov-12, Volume: 58, Issue:21 | Identification of Highly Promising Antioxidants/Neuroprotectants Based on Nucleoside 5'-Phosphorothioate Scaffold. Synthesis, Activity, and Mechanisms of Action. |
| AID1809146 | Antioxidant activity assessed as ABTS radical scavenging activity | 2021 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 52 | Design, synthesis, and cholinesterase inhibition assay of liquiritigenin derivatives as anti-Alzheimer's activity. |
| AID288847 | Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins | 2007 | Journal of natural products, Jun, Volume: 70, Issue:6 | Cyathusals A, B, and C, antioxidants from the fermented mushroom Cyathus stercoreus. |
| AID459649 | Cytotoxicity against human MRC5 cells assessed as cell death at 60 uM after 7 days by LDH assay | 2010 | Bioorganic & medicinal chemistry, Mar-01, Volume: 18, Issue:5 | Exploring a synthetic organoselenium compound for antioxidant pharmacotherapy--toxicity and effects on ROS-production. |
| AID1075993 | Antioxidant activity assessed as inhibition of ABTS radical cation formation after 15 mins by ABTS radical scavenging method | 2014 | European journal of medicinal chemistry, Mar-21, Volume: 75 | Synthesis, biological evaluation and molecular modeling study of novel tacrine-carbazole hybrids as potential multifunctional agents for the treatment of Alzheimer's disease. |
| AID1709279 | Neuroprotective activity against H2O2-induced cytotoxicity in rat PC12 cells assessed as increase in cell viability at 100 uM preincubated for 2 hrs followed by H2O2 addition and measured after 24 hrs by MTT assay | 2021 | Bioorganic & medicinal chemistry, 04-01, Volume: 35 | Novel 3-benzylidene/benzylphthalide Mannich base derivatives as potential multifunctional agents for the treatment of Alzheimer's disease. |
| AID1713227 | Cytotoxicity against human SH-SY5Y cells assessed as cell viability at 25 uM measured after 2 hrs by MTT assay relative to control | 2016 | European journal of medicinal chemistry, Nov-10, Volume: 123 | Synthesis and in vitro, ex-vivo and in vivo activity of hybrid compounds linking a potent ROS and RNS scavenger activity with diverse substrates addressed to pass across the blood-brain barrier. |
| AID427137 | Antioxidant activity assessed as superoxide radical anion scavenging activity after 30 mins by xanthine/xanthine oxidase method | 2009 | Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13 | p-Terphenyls from the fruiting bodies of Paxillus curtisii and their antioxidant properties. |
| AID738172 | Inhibition of PMA induced ROS generation in human HL60 cells assessed as inhibition of ROA mediated oxidation of DCFH | 2013 | Journal of natural products, Apr-26, Volume: 76, Issue:4 | Cytotoxicity and modulation of cancer-related signaling by (Z)- and (E)-3,4,3',5'-tetramethoxystilbene isolated from Eugenia rigida. |
| AID736826 | Neuroprotective activity in mouse HT22 cells assessed as prevention from tBuOOH-induced oxidative cell death after 3 hrs by MTS assay | 2013 | Journal of medicinal chemistry, Feb-14, Volume: 56, Issue:3 | Structure-activity relationship study of vitamin k derivatives yields highly potent neuroprotective agents. |
| AID1713232 | Cytotoxicity against human SH-SY5Y cells assessed as cell viability at 0.8 uM measured after 2 hrs by MTT assay relative to control | 2016 | European journal of medicinal chemistry, Nov-10, Volume: 123 | Synthesis and in vitro, ex-vivo and in vivo activity of hybrid compounds linking a potent ROS and RNS scavenger activity with diverse substrates addressed to pass across the blood-brain barrier. |
| AID427665 | Antioxidant activity assessed as DPPH radical scavenging activity incubated at 40 degC in dark after 30 mins | 2009 | Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13 | Potential antioxidants and tyrosinase inhibitors from synthetic polyphenolic deoxybenzoins. |
| AID1179731 | Cytoprotection in mouse CRL2181 cells assessed as reduction in UV-oxidized LDL-induced cytotoxicity by measuring cell viability at 1 uM after 24 hrs by MTT assay relative to untreated control | 2014 | Bioorganic & medicinal chemistry, Aug-01, Volume: 22, Issue:15 | Synthesis, antioxidant and cytoprotective evaluation of potential antiatherogenic phenolic hydrazones. A structure-activity relationship insight. |
| AID490418 | Cytoprotective activity against copper-induced LDL oxidation in HMEC1 cells at 10 uM after 6 hrs by MTT assay | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Synthesis and antioxidant activity evaluation of a syringic hydrazones family. |
| AID451363 | Antioxidant activity assessed as inhibition of lipid peroxidation after 60 mins by TBARS assay | 2009 | Bioorganic & medicinal chemistry, Sep-01, Volume: 17, Issue:17 | Antioxidant efficacy of iridoid and phenylethanoid glycosides from the medicinal plant Teucrium chamaedris in cell-free systems. |
| AID548182 | Antioxidant activity assessed as ABTS radical scavenging activity | 2010 | Journal of natural products, Nov-29, Volume: 73, Issue:11 | Benzophenones and biflavonoids from Rheedia edulis. |
| AID450089 | Antioxidant activity assessed as hydrogen peroxide radical scavenging activity | 2009 | Bioorganic & medicinal chemistry, Sep-15, Volume: 17, Issue:18 | Antioxidant activity of 5,10-dihydroindeno[1,2-b]indoles containing substituents on dihydroindeno part. |
| AID1603217 | Antioxidant activity assessed as DPPH radical scavenging activity at 50 uM relative to control | 2019 | Bioorganic & medicinal chemistry, 04-15, Volume: 27, Issue:8 | Designing of acyl sulphonamide based quinoxalinones as multifunctional aldose reductase inhibitors. |
| AID1892590 | Antioxidant activity in rat brain homogenate assessed as inhibition of lipid peroxidation by measuring MDA concentration at 50 uM by TBARS assay relative to control | 2022 | Journal of medicinal chemistry, 07-14, Volume: 65, Issue:13 | Novel Hydroxychalcone-Based Dual Inhibitors of Aldose Reductase and α-Glucosidase as Potential Therapeutic Agents against Diabetes Mellitus and Its Complications. |
| AID1543565 | Neuroprotective activity against H2O2-induced oxidative damage in rat PC12 cells assessed as cell viability at 10 uM measured after 24 hrs by MTT assay relative to control | 2019 | European journal of medicinal chemistry, Apr-01, Volume: 167 | Synthesis and evaluation of novel GSK-3β inhibitors as multifunctional agents against Alzheimer's disease. |
| AID1083343 | Antiviral activity against Vesicular stomatitis virus infected Hela cells assessed as inhibition of virus-induced cytopathicity | 2011 | Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, , Volume: 20, Issue:2 | The novel amidocarbamate derivatives of ketoprofen: synthesis and biological activity. |
| AID1071849 | Antioxidant activity assessed as AAPH-induced alkoxyl radical scavenging activity by ESR spin trapping method relative to CYPMPO | 2014 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 24, Issue:5 | A multiple free-radical scavenging (MULTIS) study on the antioxidant capacity of a neuroprotective drug, edaravone as compared with uric acid, glutathione, and trolox. |
| AID1326563 | Genotoxicity in Escherichia coli PQ37 expressing lacZ gene assessed as ratio of inducible beta-galactosidase activity to alkaline phosphatase activity at 3 mM after 2 hrs by SOS-chromotest relative to control | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Antioxidant and antitumor activity of trolox, trolox succinate, and α-tocopheryl succinate conjugates with nitroxides. |
| AID1594823 | Antioxidant activity assessed as DPPH radical scavenging activity | 2019 | Journal of natural products, 06-28, Volume: 82, Issue:6 | Konamycins A and B and Rubromycins CA1 and CA2, Aromatic Polyketides from the Tunicate-Derived Streptomyces hyaluromycini MB-PO13 |
| AID1713231 | Cytotoxicity against human SH-SY5Y cells assessed as cell viability at 1.6 uM measured after 2 hrs by MTT assay relative to control | 2016 | European journal of medicinal chemistry, Nov-10, Volume: 123 | Synthesis and in vitro, ex-vivo and in vivo activity of hybrid compounds linking a potent ROS and RNS scavenger activity with diverse substrates addressed to pass across the blood-brain barrier. |
| AID1071847 | Antioxidant activity assessed as DMSO/H2O2-induced methyl radical scavenging activity by ESR spin trapping method relative to DMPO | 2014 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 24, Issue:5 | A multiple free-radical scavenging (MULTIS) study on the antioxidant capacity of a neuroprotective drug, edaravone as compared with uric acid, glutathione, and trolox. |
| AID1306591 | Antioxidant activity assessed as inhibition of DPPH free radical scavenging activity by EPR spectrophotometry | 2016 | Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16 | Synthesis and evaluation of antioxidant phenolic diaryl hydrazones as potent antiangiogenic agents in atherosclerosis. |
| AID1730599 | Antioxidant activity assessed as DPPH radical scavenging activity incubated for 30 mins under dark condition | 2021 | European journal of medicinal chemistry, Mar-05, Volume: 213 | Design, synthesis, and biological evaluation of novel xanthone-alkylbenzylamine hybrids as multifunctional agents for the treatment of Alzheimer's disease. |
| AID377071 | Antioxidant activity assessed as DPPH radical scavenging activity studied at DPPH to compound ratio of 2 | 2005 | Journal of natural products, Feb, Volume: 68, Issue:2 | Identification of radical scavenging compounds in Rhaponticum carthamoides by means of LC-DAD-SPE-NMR. |
| AID1299566 | Antioxidant activity assessed as ABTS free radical scavenging activity after 6 mins by ABTS free radical decolorization assay | 2016 | Journal of natural products, Feb-26, Volume: 79, Issue:2 | Cystoseira usneoides: A Brown Alga Rich in Antioxidant and Anti-inflammatory Meroditerpenoids. |
| AID195017 | LPO-lowering activity was estimated by the IC50 value of compound in rat liver microsomal lipid peroxidation | 1990 | Journal of medicinal chemistry, May, Volume: 33, Issue:5 | Studies on hindered phenols and analogues. 2. 1,3-Benzoxathioles having SRS-A inhibiting activity. |
| AID1322937 | Antioxidant activity of the compound assessed as time required to induce AAPH-mediated linoleic acid peroxidation (Rvb = 40 to 60 mins) | 2016 | European journal of medicinal chemistry, Oct-04, Volume: 121 | Donepezil-like multifunctional agents: Design, synthesis, molecular modeling and biological evaluation. |
| AID1159607 | Screen for inhibitors of RMI FANCM (MM2) intereaction | 2016 | Journal of biomolecular screening, Jul, Volume: 21, Issue:6 | A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway. |
| AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | |||
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID1745845 | Primary qHTS for Inhibitors of ATXN expression | |||
| AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID540299 | A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis | 2010 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21 | Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. |
| AID588519 | A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities | 2011 | Antiviral research, Sep, Volume: 91, Issue:3 | High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors. |
| AID1794808 | Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL). | 2014 | Journal of biomolecular screening, Jul, Volume: 19, Issue:6 | A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum. |
| AID1794808 | Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL). | |||
| AID1802996 | AChE Inhibition Bioassay from Article 10.3109/14756366.2010.529806: \\Bifunctional phenolic-choline conjugates as anti-oxidants and acetylcholinesterase inhibitors.\\ | 2011 | Journal of enzyme inhibition and medicinal chemistry, Aug, Volume: 26, Issue:4 | Bifunctional phenolic-choline conjugates as anti-oxidants and acetylcholinesterase inhibitors. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 21 (1.41) | 18.7374 |
| 1990's | 244 (16.41) | 18.2507 |
| 2000's | 555 (37.32) | 29.6817 |
| 2010's | 586 (39.41) | 24.3611 |
| 2020's | 81 (5.45) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (34.27) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 16 (1.04%) | 5.53% |
| Reviews | 18 (1.17%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 1 (0.06%) | 0.25% |
| Other | 1,506 (97.73%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase IIb Open-label, Multi-centre, Extension Study to Explore the Long-term Safety and Efficacy of KH176 in Subjects With a Genetically Confirmed Mitochondrial DNA tRNALeu(UUR) m.3243A>G Mutation Who Have Completed the KHENERGYZE Study KH176-202. [NCT04604548] | Phase 2 | 15 participants (Anticipated) | Interventional | 2021-08-09 | Active, not recruiting | ||
| An Exploratory, Double-blind, Randomized, Placebo-controlled, Single-center, Two-way Cross-over Study With KH176 in Patients With the Mitochondrial DNA tRNALeu(UUR) m.3243A>G Mutation and Clinical Signs of Mitochondrial Disease [NCT02909400] | Phase 2 | 20 participants (Actual) | Interventional | 2016-09-30 | Completed | ||
| A Phase I, Randomized, Double Blind, Placebo-controlled, Dose-escalating Clinical Trial With KH176 [NCT02544217] | Phase 1 | 32 participants (Actual) | Interventional | 2015-05-31 | Completed | ||
| A Phase IIb Double-blind, Randomised, Placebo-controlled, Multi-centre, Confirmative Three-way Cross-over Study on Cognitive Function With Two Doses of KH176 in Subjects With a Genetically Confirmed Mitochondrial DNA tRNALeu(UUR) m.3243A>G Mutation. [NCT04165239] | Phase 2 | 27 participants (Actual) | Interventional | 2019-10-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||