Proteins > Retinoic acid receptor beta
Page last updated: 2024-08-07 15:53:22

Retinoic acid receptor beta

A retinoic acid receptor beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:P10826]

Synonyms

RAR-beta;
HBV-activated protein;
Nuclear receptor subfamily 1 group B member 2;
RAR-epsilon

Research

Bioassay Publications (45)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's17 (37.78)18.2507
2000's18 (40.00)29.6817
2010's8 (17.78)24.3611
2020's2 (4.44)2.80

Compounds (36)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
lg 100268Homo sapiens (human)Ki5.450522
adapaleneHomo sapiens (human)Ki0.034011
bexaroteneHomo sapiens (human)Ki2.701522
tamibaroteneHomo sapiens (human)Ki0.030011
4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthracenyl)benzoic acidHomo sapiens (human)Ki0.003011
hx 600Homo sapiens (human)Ki0.680011
cd 437Homo sapiens (human)Ki2.480011
6-(1,2,3,4-tetrahydro-1,1,4,4-tetramethyl-6-naphthyl)-2-naphthalenecarboxylic acidHomo sapiens (human)Ki0.013011
cd 2019Homo sapiens (human)Ki0.026011
agn 193109Homo sapiens (human)IC500.020011
tretinoinHomo sapiens (human)IC500.753744
tretinoinHomo sapiens (human)Ki0.009533
alitretinoinHomo sapiens (human)IC500.007011
alitretinoinHomo sapiens (human)Ki0.010911
lg 100567Homo sapiens (human)Ki0.045412
4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acidHomo sapiens (human)IC500.005011
4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acidHomo sapiens (human)Ki0.005011
pregna-4,17-diene-3,16-dioneHomo sapiens (human)IC50100.000011
lg100754Homo sapiens (human)Ki2.587011
lg 1506Homo sapiens (human)Ki7.100022
bms453Homo sapiens (human)Ki0.016711
hx 630Homo sapiens (human)Ki0.320011
le 135Homo sapiens (human)Ki0.220011

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
am 580Homo sapiens (human)EC500.026366
am 580Homo sapiens (human)Kd1.380522
bms 961Homo sapiens (human)EC501.650011
tazaroteneHomo sapiens (human)EC500.000811
adapaleneHomo sapiens (human)EC500.002011
bexaroteneHomo sapiens (human)EC506.760733
bexaroteneHomo sapiens (human)Kd1.000011
tamibaroteneHomo sapiens (human)EC500.235011
cd 437Homo sapiens (human)EC500.226011
agn 193109Homo sapiens (human)Kd0.005333
tretinoinHomo sapiens (human)EC500.03441919
tretinoinHomo sapiens (human)Kd0.00861113
bms 961Homo sapiens (human)Kd0.528011
alitretinoinHomo sapiens (human)EC500.023799
alitretinoinHomo sapiens (human)Kd0.049246
ac 55649Homo sapiens (human)EC503.829455
lg 100567Homo sapiens (human)EC500.013112
4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acidHomo sapiens (human)EC500.004333
agn 191659Homo sapiens (human)EC500.023011
agn 191701Homo sapiens (human)EC500.000011
pregna-4,17-diene-3,16-dioneHomo sapiens (human)EC50100.000011
agn 190121Homo sapiens (human)EC500.007011
agn 190121Homo sapiens (human)Kd0.020011
lg100754Homo sapiens (human)EC500.010011
nrx 194204Homo sapiens (human)Kd0.030011
agn 194204Homo sapiens (human)Kd20.500011
adaroteneHomo sapiens (human)EC500.200011
sr 11302Homo sapiens (human)EC501.000011
cd 666Homo sapiens (human)EC500.140011
cd 666Homo sapiens (human)Kd1.536013
agn 190205Homo sapiens (human)EC500.000311
ac 261066Homo sapiens (human)EC500.138733

Drugs with Other Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
am 580Homo sapiens (human)EC300.012011
tamibaroteneHomo sapiens (human)EC300.048011
6-(1,2,3,4-tetrahydro-1,1,4,4-tetramethyl-6-naphthyl)-2-naphthalenecarboxylic acidHomo sapiens (human)AC500.052011
tretinoinHomo sapiens (human)EC300.000822
tretinoinHomo sapiens (human)Relative EC300.001622
tretinoinHomo sapiens (human)Relative IC500.000722
alitretinoinHomo sapiens (human)AC500.002011
sr 11217Homo sapiens (human)AC501.000011
4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acidHomo sapiens (human)AC500.022011

Enables

This protein enables 9 target(s):

TargetCategoryDefinition
DNA-binding transcription factor activity, RNA polymerase II-specificmolecular functionA DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. [GOC:txnOH-2018]
DNA bindingmolecular functionAny molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
zinc ion bindingmolecular functionBinding to a zinc ion (Zn). [GOC:ai]
protein-containing complex bindingmolecular functionBinding to a macromolecular complex. [GOC:jl]
nuclear retinoid X receptor bindingmolecular functionBinding to a nuclear retinoid X receptor. [GOC:ai]
heterocyclic compound bindingmolecular functionBinding to heterocyclic compound. [GOC:TermGenie]
sequence-specific double-stranded DNA bindingmolecular functionBinding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding. [GOC:dos, GOC:sl]
RNA polymerase II cis-regulatory region sequence-specific DNA bindingmolecular functionBinding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. [GOC:txnOH-2018]
nuclear receptor activitymolecular functionA DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytosol, which leads to its translocation to the nucleus. [GOC:txnOH-2018, PMID:23457262]

Located In

This protein is located in 3 target(s):

TargetCategoryDefinition
nucleuscellular componentA membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
nucleoplasmcellular componentThat part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytoplasmcellular componentThe contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]

Active In

This protein is active in 1 target(s):

TargetCategoryDefinition
nucleuscellular componentA membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]

Part Of

This protein is part of 1 target(s):

TargetCategoryDefinition
chromatincellular componentThe ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. [GOC:elh, PMID:20404130]

Involved In

This protein is involved in 23 target(s):

TargetCategoryDefinition
ureteric bud developmentbiological processThe process whose specific outcome is the progression of the ureteric bud over time, from its formation to the mature structure. [GOC:go_curators]
glandular epithelial cell developmentbiological processThe process whose specific outcome is the progression of a glandular epithelial cell over time, from its formation to the mature structure. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland. [GOC:dph]
growth plate cartilage developmentbiological processThe process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones as they elongate or grow. [GOC:ascb_2009, GOC:dph, GOC:tb]
apoptotic processbiological processA programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
signal transductionbiological processThe cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. [GOC:go_curators, GOC:mtg_signaling_feb11]
striatum developmentbiological processThe progression of the striatum over time from its initial formation until its mature state. The striatum is a region of the forebrain consisting of the caudate nucleus, putamen and fundus striati. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420]
neurogenesisbiological processGeneration of cells within the nervous system. [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
regulation of myelinationbiological processAny process that modulates the frequency, rate or extent of the formation of a myelin sheath around nerve axons. [GOC:mah]
negative regulation of chondrocyte differentiationbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of chondrocyte differentiation. [GOC:mah]
embryonic hindlimb morphogenesisbiological processThe process, occurring in the embryo, by which the anatomical structures of the hindlimbs are generated and organized. The hindlimbs are the posterior limbs of an animal. [ISBN:0198612001]
multicellular organism growthbiological processThe increase in size or mass of an entire multicellular organism, as opposed to cell growth. [GOC:bf, GOC:curators, GOC:dph, GOC:tb]
positive regulation of apoptotic processbiological processAny process that activates or increases the frequency, rate or extent of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis]
embryonic eye morphogenesisbiological processThe process occurring in the embryo by which the anatomical structures of the post-embryonic eye are generated and organized. [GOC:jid]
embryonic digestive tract developmentbiological processThe process whose specific outcome is the progression of the gut over time, from its formation to the mature structure during embryonic development. The gut is the region of the digestive tract extending from the beginning of the intestines to the anus. [GOC:go_curators]
ventricular cardiac muscle cell differentiationbiological processThe process in which a relatively unspecialized cell acquires specialized features of a ventricular cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The ventricle is the part of the heart that pumps blood out of the organ. [GOC:devbiol, GOC:mtg_heart]
neural precursor cell proliferationbiological processThe multiplication or reproduction of neural precursor cells, resulting in the expansion of a cell population. A neural precursor cell is either a nervous system stem cell or a nervous system progenitor cell. [GOC:dph, GOC:yaf]
stem cell proliferationbiological processThe multiplication or reproduction of stem cells, resulting in the expansion of a stem cell population. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. [GOC:mtg_kidney_jan10]
negative regulation of stem cell proliferationbiological processAny process that stops, prevents or reduces the frequency, rate or extent of stem cell proliferation. [GOC:dph]
retinoic acid receptor signaling pathwaybiological processThe series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands. [GOC:dgh]
hormone-mediated signaling pathwaybiological processThe series of molecular signals mediated by the detection of a hormone. [GOC:sm]
negative regulation of transcription by RNA polymerase IIbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]
positive regulation of transcription by RNA polymerase IIbiological processAny process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. [GOC:go_curators, GOC:txnOH]
cell differentiationbiological processThe cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. [ISBN:0198506732]