A nicotinamide N-methyltransferase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P40261]
EC 2.1.1.1
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (57.14) | 24.3611 |
| 2020's | 3 (42.86) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| benzamide | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| 1,2,3,4-tetrahydroisoquinoline | Homo sapiens (human) | Ki | 47,000.0000 | 1 | 1 |
| quinoline | Homo sapiens (human) | Ki | 102,000.0000 | 1 | 1 |
| isoquinoline | Homo sapiens (human) | Ki | 202,000.0000 | 1 | 1 |
| 6-aminonicotinamide | Homo sapiens (human) | IC50 | 3.6200 | 1 | 1 |
| sinefungin | Homo sapiens (human) | IC50 | 39.2367 | 3 | 3 |
| n'-methyl-2-pyridone-5-carboxamide | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
| 4-Methoxybenzamide | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
| n(4)-adenosyl-n(4)-methyl-2,4-diaminobutanoic acid | Homo sapiens (human) | IC50 | 25.0000 | 1 | 1 |
| s-adenosylhomocysteine | Homo sapiens (human) | IC50 | 35.3000 | 1 | 1 |
| thionicotinamide | Homo sapiens (human) | Ki | 66,000.0000 | 1 | 1 |
| quinoline-3-carboxamide | Homo sapiens (human) | Ki | 97,000.0000 | 1 | 1 |
This protein enables 2 target(s):
| Target | Category | Definition |
|---|---|---|
| nicotinamide N-methyltransferase activity | molecular function | Catalysis of the reaction: S-adenosyl-L-methionine(1+) + nicotinamide = 1-methylnicotinamide + S-adenosyl-L-homocysteine. [EC:2.1.1.1, RHEA:23884] |
| pyridine N-methyltransferase activity | molecular function | Catalysis of the reaction: S-adenosyl-L-methionine(1+) + pyridine = N-methylpyridinium + S-adenosyl-L-homocysteine. [EC:2.1.1.87, RHEA:16893] |
This protein is located in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
This protein is involved in 8 target(s):
| Target | Category | Definition |
|---|---|---|
| nicotinamide metabolic process | biological process | The chemical reactions and pathways involving nicotinamide, pyridine-3-carboxamide, the amide of nicotinic acid. It is a member of the B complex of vitamins and occurs widely in living organisms. [ISBN:0198506732] |
| response to xenobiotic stimulus | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:jl, GOC:krc] |
| response to organonitrogen compound | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond. [PMID:9869419] |
| animal organ regeneration | biological process | The regrowth of a lost or destroyed animal organ. [GOC:mah] |
| methylation | biological process | The process in which a methyl group is covalently attached to a molecule. [GOC:mah] |
| NAD biosynthesis via nicotinamide riboside salvage pathway | biological process | The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD) from the vitamin precursor nicotinamide riboside. [PMID:17482543] |
| positive regulation of gluconeogenesis | biological process | Any process that activates or increases the frequency, rate or extent of gluconeogenesis. [GOC:go_curators] |
| positive regulation of protein deacetylation | biological process | Any process that increases the rate, frequency, or extent of protein deacetylation, the removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid. [GOC:ecd, PMID:20027304] |