Page last updated: 2024-08-07 15:40:12
Beta-lactamase
[no definition available]
Synonyms
EC 3.5.2.6;
Cephalosporinase
Research
Bioassay Publications (16)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (12.50) | 18.2507 |
| 2000's | 11 (68.75) | 29.6817 |
| 2010's | 3 (18.75) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (25)
Drugs with Inhibition Measurements
Drugs with Other Measurements
Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem.Antimicrobial agents and chemotherapy, , Volume: 54, Issue:1, 2010
Interactions of ceftobiprole with beta-lactamases from molecular classes A to D.Antimicrobial agents and chemotherapy, , Volume: 51, Issue:9, 2007
Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem.Antimicrobial agents and chemotherapy, , Volume: 54, Issue:1, 2010
Interactions of ceftobiprole with beta-lactamases from molecular classes A to D.Antimicrobial agents and chemotherapy, , Volume: 51, Issue:9, 2007
Mechanistic studies of the inactivation of TEM-1 and P99 by NXL104, a novel non-beta-lactam beta-lactamase inhibitor.Antimicrobial agents and chemotherapy, , Volume: 54, Issue:12, 2010
4-Substituted trinems as broad spectrum beta-lactamase inhibitors: structure-based design, synthesis, and biological activity.Journal of medicinal chemistry, , Aug-23, Volume: 50, Issue:17, 2007
Structure-activity relationship of 6-methylidene penems bearing 6,5 bicyclic heterocycles as broad-spectrum beta-lactamase inhibitors: evidence for 1,4-thiazepine intermediates with C7 R stereochemistry by computational methods.Journal of medicinal chemistry, , Jul-27, Volume: 49, Issue:15, 2006
Spirocyclopropyl beta-lactams as mechanism-based inhibitors of serine beta-lactamases. Synthesis by rhodium-catalyzed cyclopropanation of 6-diazopenicillanate sulfone.Journal of medicinal chemistry, , Jun-19, Volume: 46, Issue:13, 2003
Cephalosporin-derived inhibitors of beta-lactamase. Part 4: The C3 substituent.Bioorganic & medicinal chemistry letters, , Jun-17, Volume: 12, Issue:12, 2002
The synthesis and SAR of rhodanines as novel class C beta-lactamase inhibitors.Bioorganic & medicinal chemistry letters, , Oct-02, Volume: 10, Issue:19, 2000
Design, synthesis, and evaluation of 2 beta-alkenyl penam sulfone acids as inhibitors of beta-lactamases.Journal of medicinal chemistry, , Sep-13, Volume: 39, Issue:19, 1996
Mechanistic studies of the inactivation of TEM-1 and P99 by NXL104, a novel non-beta-lactam beta-lactamase inhibitor.Antimicrobial agents and chemotherapy, , Volume: 54, Issue:12, 2010
Spirocyclopropyl beta-lactams as mechanism-based inhibitors of serine beta-lactamases. Synthesis by rhodium-catalyzed cyclopropanation of 6-diazopenicillanate sulfone.Journal of medicinal chemistry, , Jun-19, Volume: 46, Issue:13, 2003
Mechanistic studies of the inactivation of TEM-1 and P99 by NXL104, a novel non-beta-lactam beta-lactamase inhibitor.Antimicrobial agents and chemotherapy, , Volume: 54, Issue:12, 2010
4-Substituted trinems as broad spectrum beta-lactamase inhibitors: structure-based design, synthesis, and biological activity.Journal of medicinal chemistry, , Aug-23, Volume: 50, Issue:17, 2007
Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem.Antimicrobial agents and chemotherapy, , Volume: 54, Issue:1, 2010
Interactions of ceftobiprole with beta-lactamases from molecular classes A to D.Antimicrobial agents and chemotherapy, , Volume: 51, Issue:9, 2007
Structure-activity relationship of 6-methylidene penems bearing tricyclic heterocycles as broad-spectrum beta-lactamase inhibitors: crystallographic structures show unexpected binding of 1,4-thiazepine intermediates.Journal of medicinal chemistry, , Dec-16, Volume: 47, Issue:26, 2004
Synthesis and biological activity of 7-alkylidenecephems.Journal of medicinal chemistry, , Mar-17, Volume: 38, Issue:6, 1995