Proteins > 5-hydroxytryptamine receptor 7
Page last updated: 2024-08-07 16:30:38
5-hydroxytryptamine receptor 7
A 5-hydroxytryptamine receptor 7 that is encoded in the genome of rat. [OMA:P32305, PRO:DNx]
Synonyms
5-HT-7;
5-HT7;
5-HT-X;
GPRFO;
Serotonin receptor 7
Research
Bioassay Publications (30)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 6 (20.00) | 18.7374 |
| 1990's | 4 (13.33) | 18.2507 |
| 2000's | 17 (56.67) | 29.6817 |
| 2010's | 2 (6.67) | 24.3611 |
| 2020's | 1 (3.33) | 2.80 |
Compounds (86)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| phenethylamine | Rattus norvegicus (Norway rat) | Kd | 5.4954 | 2 | 4 |
| 4-iodo-2,5-dimethoxyphenylisopropylamine | Rattus norvegicus (Norway rat) | Kd | 0.0324 | 1 | 1 |
| 3,4-methylenedioxyamphetamine | Rattus norvegicus (Norway rat) | Kd | 0.3548 | 1 | 2 |
| amphetamine | Rattus norvegicus (Norway rat) | Kd | 5.3703 | 3 | 5 |
| mescaline | Rattus norvegicus (Norway rat) | Kd | 2.2387 | 1 | 2 |
| o-methyltyramine | Rattus norvegicus (Norway rat) | Kd | 7.9433 | 1 | 2 |
| spiperone | Rattus norvegicus (Norway rat) | Kd | 0.0001 | 1 | 1 |
| tyramine | Rattus norvegicus (Norway rat) | Kd | 8.5114 | 1 | 2 |
| dextroamphetamine | Rattus norvegicus (Norway rat) | Kd | 4.4668 | 1 | 2 |
| n,n-dimethyltryptamine | Rattus norvegicus (Norway rat) | Kd | 1.0000 | 1 | 1 |
| dimethoxyphenylethylamine | Rattus norvegicus (Norway rat) | Kd | 4.3652 | 1 | 2 |
| 3,4-dimethoxyamphetamine | Rattus norvegicus (Norway rat) | Kd | 3.5481 | 1 | 2 |
| 3-phenylpropylamine | Rattus norvegicus (Norway rat) | Kd | 11.7490 | 1 | 2 |
| 2,5-dimethoxy-4-ethylamphetamine | Rattus norvegicus (Norway rat) | Kd | 0.0661 | 2 | 3 |
| 2,4,5-trimethoxyphenylisopropylamine | Rattus norvegicus (Norway rat) | Kd | 0.1549 | 2 | 3 |
| 4-methoxyamphetamine | Rattus norvegicus (Norway rat) | Kd | 7.0795 | 2 | 3 |
| l-amphetamine | Rattus norvegicus (Norway rat) | Kd | 6.9183 | 1 | 2 |
| 2-aminotetralin | Rattus norvegicus (Norway rat) | Kd | 2.4547 | 1 | 2 |
| 2,5-dimethoxy-4-bromoamphetamine | Rattus norvegicus (Norway rat) | Kd | 0.0447 | 2 | 3 |
| cathinone | Rattus norvegicus (Norway rat) | Kd | 3.0200 | 1 | 2 |
| 2,5-dimethoxyamphetamine | Rattus norvegicus (Norway rat) | Kd | 0.1479 | 2 | 3 |
| 3,4-methylenedioxyphenethylamine | Rattus norvegicus (Norway rat) | Kd | 0.7943 | 1 | 2 |
| 3-methoxy-4-hydroxyphenylethylamine | Rattus norvegicus (Norway rat) | Kd | 1.2882 | 1 | 2 |
| 2-(2,5-dimethoxyphenyl)ethanamine | Rattus norvegicus (Norway rat) | Kd | 0.1412 | 1 | 2 |
| 2,5-dimethoxy-4-methylamphetamine | Rattus norvegicus (Norway rat) | Kd | 0.0753 | 2 | 3 |
| 1-(2,5-dimethoxy-4-nitrophenyl)-2-aminopropane | Rattus norvegicus (Norway rat) | Kd | 0.0851 | 1 | 1 |
| 3-methoxyamphetamine | Rattus norvegicus (Norway rat) | Kd | 1.1749 | 3 | 4 |
| n-desmethylmethoxyphenamine | Rattus norvegicus (Norway rat) | Kd | 2.8840 | 2 | 3 |
| 4-iodo-2,5-dimethoxyphenylisopropylamine, (r)-isomer | Rattus norvegicus (Norway rat) | Kd | 0.0234 | 1 | 1 |
| 2,5-dimethoxy-4-bromoamphetamine, (s)-isomer | Rattus norvegicus (Norway rat) | Kd | 0.1175 | 1 | 1 |
| vu0357017 | Rattus norvegicus (Norway rat) | EC50 | 95.7200 | 1 | 0 |
Structure-activity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides, a class of 5-HT7 receptor agents. 2.Journal of medicinal chemistry, , Aug-23, Volume: 50, Issue:17, 2007
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).Journal of medicinal chemistry, , Jul-03, Volume: 46, Issue:14, 2003
Investigations on the 1-(2-biphenyl)piperazine motif: identification of new potent and selective ligands for the serotonin(7) (5-HT(7)) receptor with agonist or antagonist action in vitro or ex vivo.Journal of medicinal chemistry, , Jul-26, Volume: 55, Issue:14, 2012
Characterization of the 5-HT(7) receptor. Determination of the pharmacophore for 5-HT(7) receptor agonism and CoMFA-based modeling of the agonist binding site.Journal of medicinal chemistry, , Dec-04, Volume: 46, Issue:25, 2003
Investigations on the 1-(2-biphenyl)piperazine motif: identification of new potent and selective ligands for the serotonin(7) (5-HT(7)) receptor with agonist or antagonist action in vitro or ex vivo.Journal of medicinal chemistry, , Jul-26, Volume: 55, Issue:14, 2012
Characterization of the 5-HT(7) receptor. Determination of the pharmacophore for 5-HT(7) receptor agonism and CoMFA-based modeling of the agonist binding site.Journal of medicinal chemistry, , Dec-04, Volume: 46, Issue:25, 2003
Structural modifications of N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides: influence on lipophilicity and 5-HT7 receptor activity. Part III.Journal of medicinal chemistry, , Sep-25, Volume: 51, Issue:18, 2008
Structure-activity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides, a class of 5-HT7 receptor agents. 2.Journal of medicinal chemistry, , Aug-23, Volume: 50, Issue:17, 2007
Bivalent ligand approach on 4-[2-(3-methoxyphenyl)ethyl]-1-(2-methoxyphenyl)piperazine: synthesis and binding affinities for 5-HT(7) and 5-HT(1A) receptors.Bioorganic & medicinal chemistry, , Aug-01, Volume: 15, Issue:15, 2007
Structure-affinity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinealkylamides, a new class of 5-hydroxytryptamine7 receptor agents.Journal of medicinal chemistry, , Dec-16, Volume: 47, Issue:26, 2004
Synthesis and structure-affinity relationships of 1-[omega-(4-aryl-1-piperazinyl)alkyl]-1-aryl ketones as 5-HT(7) receptor ligands.Journal of medicinal chemistry, , Feb-13, Volume: 46, Issue:4, 2003
Characterization of the 5-HT(7) receptor. Determination of the pharmacophore for 5-HT(7) receptor agonism and CoMFA-based modeling of the agonist binding site.Journal of medicinal chemistry, , Dec-04, Volume: 46, Issue:25, 2003
Derivatives of (R)-1,11-methyleneaporphine: synthesis, structure, and interactions with G-protein coupled receptors.Journal of medicinal chemistry, , Apr-06, Volume: 43, Issue:7, 2000
Serotonin receptor affinity of cathinone and related analogues.Journal of medicinal chemistry, , Volume: 25, Issue:4, 1982
Behavioral and serotonin receptor properties of 4-substituted derivatives of the hallucinogen 1-(2,5-dimethoxyphenyl)-2-aminopropane.Journal of medicinal chemistry, , Volume: 25, Issue:10, 1982
Serotonin receptor affinities of psychoactive phenalkylamine analogues.Journal of medicinal chemistry, , Volume: 23, Issue:3, 1980
Structure-activity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides, a class of 5-HT7 receptor agents. 2.Journal of medicinal chemistry, , Aug-23, Volume: 50, Issue:17, 2007
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).Journal of medicinal chemistry, , Jul-03, Volume: 46, Issue:14, 2003
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).Journal of medicinal chemistry, , Jul-03, Volume: 46, Issue:14, 2003
First pharmacophoric hypothesis for 5-HT7 antagonism.Bioorganic & medicinal chemistry letters, , May-15, Volume: 10, Issue:10, 2000
Development of predictive retention-activity relationship models of tricyclic antidepressants by micellar liquid chromatography.Journal of medicinal chemistry, , Aug-12, Volume: 42, Issue:16, 1999
[no title available]European journal of medicinal chemistry, , Dec-01, Volume: 207, 2020
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).Journal of medicinal chemistry, , Jul-03, Volume: 46, Issue:14, 2003
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).Journal of medicinal chemistry, , Jul-03, Volume: 46, Issue:14, 2003
First pharmacophoric hypothesis for 5-HT7 antagonism.Bioorganic & medicinal chemistry letters, , May-15, Volume: 10, Issue:10, 2000
Structure-activity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides, a class of 5-HT7 receptor agents. 2.Journal of medicinal chemistry, , Aug-23, Volume: 50, Issue:17, 2007
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).Journal of medicinal chemistry, , Jul-03, Volume: 46, Issue:14, 2003
First pharmacophoric hypothesis for 5-HT7 antagonism.Bioorganic & medicinal chemistry letters, , May-15, Volume: 10, Issue:10, 2000
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).Journal of medicinal chemistry, , Jul-03, Volume: 46, Issue:14, 2003
Characterization of the 5-HT(7) receptor. Determination of the pharmacophore for 5-HT(7) receptor agonism and CoMFA-based modeling of the agonist binding site.Journal of medicinal chemistry, , Dec-04, Volume: 46, Issue:25, 2003
Atropisomeric derivatives of 2',6'-disubstituted (R)-11-phenylaporphine: selective serotonin 5-HT(7) receptor antagonists.Journal of medicinal chemistry, , Apr-26, Volume: 44, Issue:9, 2001
Serotonergic and dopaminergic activities of rigidified (R)-aporphine derivatives.Bioorganic & medicinal chemistry letters, , Feb-12, Volume: 11, Issue:3, 2001
Derivatives of (R)-1,11-methyleneaporphine: synthesis, structure, and interactions with G-protein coupled receptors.Journal of medicinal chemistry, , Apr-06, Volume: 43, Issue:7, 2000
Resolution and absolute configuration of the potent dopamine agonist N,N-diethyl-N'-[(3 alpha, 4a alpha, 10a beta)-1,2,3,4,4a,5,10,10a- -octahydro-6-hydroxy-1-propyl-3-benzo[g]quinolinyl]sulfamide.Journal of medicinal chemistry, , Volume: 28, Issue:10, 1985
Octahydrobenzo[g]quinolines: potent dopamine agonists which show the relationship between ergolines and apomorphine.Journal of medicinal chemistry, , Volume: 28, Issue:3, 1985
Resolution and absolute configuration of the potent dopamine agonist N,N-diethyl-N'-[(3 alpha, 4a alpha, 10a beta)-1,2,3,4,4a,5,10,10a- -octahydro-6-hydroxy-1-propyl-3-benzo[g]quinolinyl]sulfamide.Journal of medicinal chemistry, , Volume: 28, Issue:10, 1985
Octahydrobenzo[g]quinolines: potent dopamine agonists which show the relationship between ergolines and apomorphine.Journal of medicinal chemistry, , Volume: 28, Issue:3, 1985
Behavioral and serotonin receptor properties of 4-substituted derivatives of the hallucinogen 1-(2,5-dimethoxyphenyl)-2-aminopropane.Journal of medicinal chemistry, , Volume: 25, Issue:10, 1982
Studies on several 7-substituted N,N-dimethyltryptamines.Journal of medicinal chemistry, , Volume: 23, Issue:11, 1980
Serotonin receptor affinities of psychoactive phenalkylamine analogues.Journal of medicinal chemistry, , Volume: 23, Issue:3, 1980
Resolution and absolute configuration of the potent dopamine agonist N,N-diethyl-N'-[(3 alpha, 4a alpha, 10a beta)-1,2,3,4,4a,5,10,10a- -octahydro-6-hydroxy-1-propyl-3-benzo[g]quinolinyl]sulfamide.Journal of medicinal chemistry, , Volume: 28, Issue:10, 1985
Octahydrobenzo[g]quinolines: potent dopamine agonists which show the relationship between ergolines and apomorphine.Journal of medicinal chemistry, , Volume: 28, Issue:3, 1985
Characterization of the 5-HT(7) receptor. Determination of the pharmacophore for 5-HT(7) receptor agonism and CoMFA-based modeling of the agonist binding site.Journal of medicinal chemistry, , Dec-04, Volume: 46, Issue:25, 2003
Derivatives of (R)-1,11-methyleneaporphine: synthesis, structure, and interactions with G-protein coupled receptors.Journal of medicinal chemistry, , Apr-06, Volume: 43, Issue:7, 2000
Novel 5-HT7 receptor inverse agonists. Synthesis and molecular modeling of arylpiperazine- and 1,2,3,4-tetrahydroisoquinoline-based arylsulfonamides.Journal of medicinal chemistry, , Oct-21, Volume: 47, Issue:22, 2004
Atropisomeric derivatives of 2',6'-disubstituted (R)-11-phenylaporphine: selective serotonin 5-HT(7) receptor antagonists.Journal of medicinal chemistry, , Apr-26, Volume: 44, Issue:9, 2001
Novel 5-HT7 receptor inverse agonists. Synthesis and molecular modeling of arylpiperazine- and 1,2,3,4-tetrahydroisoquinoline-based arylsulfonamides.Journal of medicinal chemistry, , Oct-21, Volume: 47, Issue:22, 2004
First pharmacophoric hypothesis for 5-HT7 antagonism.Bioorganic & medicinal chemistry letters, , May-15, Volume: 10, Issue:10, 2000
Design, synthesis, radiolabeling and in vivo evaluation of potential positron emission tomography (PET) radioligands for brain imaging of the 5-HT₇ receptor.Bioorganic & medicinal chemistry, , Mar-01, Volume: 22, Issue:5, 2014
Investigations on the 1-(2-biphenyl)piperazine motif: identification of new potent and selective ligands for the serotonin(7) (5-HT(7)) receptor with agonist or antagonist action in vitro or ex vivo.Journal of medicinal chemistry, , Jul-26, Volume: 55, Issue:14, 2012
Structural modifications of N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides: influence on lipophilicity and 5-HT7 receptor activity. Part III.Journal of medicinal chemistry, , Sep-25, Volume: 51, Issue:18, 2008
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).Journal of medicinal chemistry, , Jul-03, Volume: 46, Issue:14, 2003
First pharmacophoric hypothesis for 5-HT7 antagonism.Bioorganic & medicinal chemistry letters, , May-15, Volume: 10, Issue:10, 2000