Page last updated: 2024-08-07 16:30:38
5-hydroxytryptamine receptor 7
A 5-hydroxytryptamine receptor 7 that is encoded in the genome of rat. [OMA:P32305, PRO:DNx]
Synonyms
5-HT-7;
5-HT7;
5-HT-X;
GPRFO;
Serotonin receptor 7
Research
Bioassay Publications (30)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 6 (20.00) | 18.7374 |
| 1990's | 4 (13.33) | 18.2507 |
| 2000's | 17 (56.67) | 29.6817 |
| 2010's | 2 (6.67) | 24.3611 |
| 2020's | 1 (3.33) | 2.80 |
Compounds (86)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| 8-hydroxy-2-(di-n-propylamino)tetralin | Rattus norvegicus (Norway rat) | Ki | 0.0760 | 2 | 2 |
| 1-(1-naphthyl)piperazine | Rattus norvegicus (Norway rat) | Ki | 0.0506 | 2 | 2 |
| 1-(2-methoxyphenyl)piperazine | Rattus norvegicus (Norway rat) | Ki | 0.1844 | 2 | 2 |
| 1-(3-chlorophenyl)piperazine | Rattus norvegicus (Norway rat) | Ki | 0.3520 | 1 | 1 |
| 5-carboxamidotryptamine | Rattus norvegicus (Norway rat) | Ki | 0.0004 | 8 | 8 |
| methylbufotenin | Rattus norvegicus (Norway rat) | Ki | 0.0398 | 1 | 1 |
| 5-methoxytryptamine | Rattus norvegicus (Norway rat) | Ki | 0.0009 | 1 | 1 |
| amitriptyline | Rattus norvegicus (Norway rat) | IC50 | 0.0440 | 1 | 1 |
| chlorpromazine | Rattus norvegicus (Norway rat) | Ki | 0.0210 | 1 | 1 |
| clomipramine | Rattus norvegicus (Norway rat) | IC50 | 0.0050 | 1 | 1 |
| cyproheptadine | Rattus norvegicus (Norway rat) | Ki | 0.0501 | 1 | 1 |
| desipramine | Rattus norvegicus (Norway rat) | IC50 | 0.3500 | 1 | 1 |
| doxepin | Rattus norvegicus (Norway rat) | IC50 | 0.2000 | 1 | 1 |
| haloperidol | Rattus norvegicus (Norway rat) | Ki | 0.1325 | 2 | 2 |
| imipramine | Rattus norvegicus (Norway rat) | IC50 | 0.0440 | 1 | 1 |
| ketanserin | Rattus norvegicus (Norway rat) | Ki | 0.0035 | 1 | 1 |
| loxapine | Rattus norvegicus (Norway rat) | Ki | 0.0430 | 1 | 1 |
| methiothepin | Rattus norvegicus (Norway rat) | Ki | 0.0040 | 1 | 1 |
| mianserin | Rattus norvegicus (Norway rat) | IC50 | 5.0000 | 1 | 1 |
| mianserin | Rattus norvegicus (Norway rat) | Ki | 0.0816 | 2 | 2 |
| nan 190 | Rattus norvegicus (Norway rat) | Ki | 0.0870 | 1 | 1 |
| nortriptyline | Rattus norvegicus (Norway rat) | IC50 | 0.1700 | 1 | 1 |
| ondansetron | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| risperidone | Rattus norvegicus (Norway rat) | Ki | 0.0210 | 2 | 2 |
| ritanserin | Rattus norvegicus (Norway rat) | Ki | 0.0154 | 2 | 2 |
| spiperone | Rattus norvegicus (Norway rat) | Ki | 0.0166 | 3 | 3 |
| lysergic acid diethylamide | Rattus norvegicus (Norway rat) | Ki | 0.0058 | 2 | 2 |
| apomorphine | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 2 | 2 |
| apomorphine | Rattus norvegicus (Norway rat) | Ki | 0.1880 | 3 | 3 |
| 2-bromolysergic acid diethylamide | Rattus norvegicus (Norway rat) | Ki | 0.0100 | 1 | 1 |
| bufotenin | Rattus norvegicus (Norway rat) | Ki | 0.0079 | 1 | 1 |
| pimozide | Rattus norvegicus (Norway rat) | Ki | 0.0005 | 1 | 1 |
| metergoline | Rattus norvegicus (Norway rat) | Ki | 0.0063 | 1 | 1 |
| butaclamol | Rattus norvegicus (Norway rat) | Ki | 0.0631 | 1 | 1 |
| pergolide | Rattus norvegicus (Norway rat) | IC50 | 0.3850 | 1 | 1 |
| quinpirole | Rattus norvegicus (Norway rat) | Ki | 1.5000 | 1 | 1 |
| aripiprazole | Rattus norvegicus (Norway rat) | Ki | 0.0894 | 1 | 1 |
| ch 29717 | Rattus norvegicus (Norway rat) | Ki | 0.0210 | 1 | 1 |
| etisulergine | Rattus norvegicus (Norway rat) | IC50 | 5.0000 | 2 | 2 |
| mesulergine | Rattus norvegicus (Norway rat) | Ki | 0.0079 | 1 | 1 |
| sivelestat | Rattus norvegicus (Norway rat) | Ki | 0.2000 | 1 | 1 |
| uh 301 | Rattus norvegicus (Norway rat) | Ki | 3.1800 | 1 | 1 |
| cocaine | Rattus norvegicus (Norway rat) | Ki | 0.3010 | 1 | 1 |
| chlorprothixene | Rattus norvegicus (Norway rat) | Ki | 0.0056 | 1 | 1 |
| quinagolide | Rattus norvegicus (Norway rat) | IC50 | 5.6000 | 2 | 4 |
| mm 77 | Rattus norvegicus (Norway rat) | Ki | 0.0900 | 1 | 1 |
| preclamol | Rattus norvegicus (Norway rat) | Ki | 2.1000 | 1 | 1 |
| sb 258719 | Rattus norvegicus (Norway rat) | Ki | 0.0316 | 1 | 1 |
| 1-methyl-d-lysergic acid butanolamide | Rattus norvegicus (Norway rat) | Ki | 0.0126 | 1 | 1 |
| 8-hydroxy-2-(di-n-propylamino)tetralin, (r)-isomer | Rattus norvegicus (Norway rat) | Ki | 0.0273 | 2 | 2 |
| sb 269970 | Rattus norvegicus (Norway rat) | Ki | 0.0011 | 2 | 2 |
| cilansetron | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| vilazodone | Rattus norvegicus (Norway rat) | IC50 | 3.0000 | 1 | 1 |
| l 772405 | Rattus norvegicus (Norway rat) | IC50 | 0.5400 | 1 | 1 |
| sb258741 | Rattus norvegicus (Norway rat) | Ki | 0.0031 | 2 | 2 |
| sb-656104-a | Rattus norvegicus (Norway rat) | Ki | 0.0020 | 1 | 1 |
| n-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide | Rattus norvegicus (Norway rat) | Ki | 0.0006 | 3 | 3 |
| clozapine | Rattus norvegicus (Norway rat) | Ki | 0.0094 | 2 | 2 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| phenethylamine | Rattus norvegicus (Norway rat) | Kd | 5.4954 | 2 | 4 |
| 4-iodo-2,5-dimethoxyphenylisopropylamine | Rattus norvegicus (Norway rat) | Kd | 0.0324 | 1 | 1 |
| 3,4-methylenedioxyamphetamine | Rattus norvegicus (Norway rat) | Kd | 0.3548 | 1 | 2 |
| amphetamine | Rattus norvegicus (Norway rat) | Kd | 5.3703 | 3 | 5 |
| mescaline | Rattus norvegicus (Norway rat) | Kd | 2.2387 | 1 | 2 |
| o-methyltyramine | Rattus norvegicus (Norway rat) | Kd | 7.9433 | 1 | 2 |
| spiperone | Rattus norvegicus (Norway rat) | Kd | 0.0001 | 1 | 1 |
| tyramine | Rattus norvegicus (Norway rat) | Kd | 8.5114 | 1 | 2 |
| dextroamphetamine | Rattus norvegicus (Norway rat) | Kd | 4.4668 | 1 | 2 |
| n,n-dimethyltryptamine | Rattus norvegicus (Norway rat) | Kd | 1.0000 | 1 | 1 |
| dimethoxyphenylethylamine | Rattus norvegicus (Norway rat) | Kd | 4.3652 | 1 | 2 |
| 3,4-dimethoxyamphetamine | Rattus norvegicus (Norway rat) | Kd | 3.5481 | 1 | 2 |
| 3-phenylpropylamine | Rattus norvegicus (Norway rat) | Kd | 11.7490 | 1 | 2 |
| 2,5-dimethoxy-4-ethylamphetamine | Rattus norvegicus (Norway rat) | Kd | 0.0661 | 2 | 3 |
| 2,4,5-trimethoxyphenylisopropylamine | Rattus norvegicus (Norway rat) | Kd | 0.1549 | 2 | 3 |
| 4-methoxyamphetamine | Rattus norvegicus (Norway rat) | Kd | 7.0795 | 2 | 3 |
| l-amphetamine | Rattus norvegicus (Norway rat) | Kd | 6.9183 | 1 | 2 |
| 2-aminotetralin | Rattus norvegicus (Norway rat) | Kd | 2.4547 | 1 | 2 |
| 2,5-dimethoxy-4-bromoamphetamine | Rattus norvegicus (Norway rat) | Kd | 0.0447 | 2 | 3 |
| cathinone | Rattus norvegicus (Norway rat) | Kd | 3.0200 | 1 | 2 |
| 2,5-dimethoxyamphetamine | Rattus norvegicus (Norway rat) | Kd | 0.1479 | 2 | 3 |
| 3,4-methylenedioxyphenethylamine | Rattus norvegicus (Norway rat) | Kd | 0.7943 | 1 | 2 |
| 3-methoxy-4-hydroxyphenylethylamine | Rattus norvegicus (Norway rat) | Kd | 1.2882 | 1 | 2 |
| 2-(2,5-dimethoxyphenyl)ethanamine | Rattus norvegicus (Norway rat) | Kd | 0.1412 | 1 | 2 |
| 2,5-dimethoxy-4-methylamphetamine | Rattus norvegicus (Norway rat) | Kd | 0.0753 | 2 | 3 |
| 1-(2,5-dimethoxy-4-nitrophenyl)-2-aminopropane | Rattus norvegicus (Norway rat) | Kd | 0.0851 | 1 | 1 |
| 3-methoxyamphetamine | Rattus norvegicus (Norway rat) | Kd | 1.1749 | 3 | 4 |
| n-desmethylmethoxyphenamine | Rattus norvegicus (Norway rat) | Kd | 2.8840 | 2 | 3 |
| 4-iodo-2,5-dimethoxyphenylisopropylamine, (r)-isomer | Rattus norvegicus (Norway rat) | Kd | 0.0234 | 1 | 1 |
| 2,5-dimethoxy-4-bromoamphetamine, (s)-isomer | Rattus norvegicus (Norway rat) | Kd | 0.1175 | 1 | 1 |
| vu0357017 | Rattus norvegicus (Norway rat) | EC50 | 95.7200 | 1 | 0 |