Proteins > Sodium channel protein type 4 subunit alpha
Page last updated: 2024-08-07 18:34:22
Sodium channel protein type 4 subunit alpha
A sodium channel protein type 4 subunit alpha that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35499]
Synonyms
SkM1;
Sodium channel protein skeletal muscle subunit alpha;
Sodium channel protein type IV subunit alpha;
Voltage-gated sodium channel subunit alpha Nav1.4
Research
Bioassay Publications (10)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (30.00) | 29.6817 |
| 2010's | 6 (60.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
Compounds (30)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| tocainide, (s)-isomer | Homo sapiens (human) | EC50 | 223.8720 | 1 | 1 |
Drugs with Other Measurements
The discovery of a potent NaMedChemComm, , Jun-01, Volume: 8, Issue:6, 2017
Voltage-Gated Sodium Channels: Structure, Function, Pharmacology, and Clinical Indications.Journal of medicinal chemistry, , Sep-24, Volume: 58, Issue:18, 2015
Challenges and Opportunities for Therapeutics Targeting the Voltage-Gated Sodium Channel Isoform NaJournal of medicinal chemistry, , 10-10, Volume: 62, Issue:19, 2019
Ion channels as therapeutic targets: a drug discovery perspective.Journal of medicinal chemistry, , Feb-14, Volume: 56, Issue:3, 2013
[no title available],
Discovery of Selective Inhibitors of NaACS medicinal chemistry letters, , Nov-10, Volume: 13, Issue:11, 2022
Challenges and Opportunities for Therapeutics Targeting the Voltage-Gated Sodium Channel Isoform NaJournal of medicinal chemistry, , 10-10, Volume: 62, Issue:19, 2019
Enables
This protein enables 2 target(s):
| Target | Category | Definition |
|---|
| voltage-gated sodium channel activity | molecular function | Enables the transmembrane transfer of a sodium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:mtg_transport, ISBN:0815340729] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
Located In
This protein is located in 1 target(s):
| Target | Category | Definition |
|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
Part Of
This protein is part of 1 target(s):
| Target | Category | Definition |
|---|
| voltage-gated sodium channel complex | cellular component | A sodium channel in a cell membrane whose opening is governed by the membrane potential. [ISBN:0198506732] |
Involved In
This protein is involved in 5 target(s):
| Target | Category | Definition |
|---|
| sodium ion transport | biological process | The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai] |
| muscle contraction | biological process | A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. [GOC:ef, GOC:mtg_muscle, ISBN:0198506732] |
| sodium ion transmembrane transport | biological process | A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:vw] |
| regulation of skeletal muscle contraction by action potential | biological process | Any action potential process that regulates skeletal muscle contraction. [GOC:cjm, GOC:obol] |
| cardiac muscle cell action potential involved in contraction | biological process | An action potential that occurs in a cardiac muscle cell and is involved in its contraction. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] |