naproxen

Research Excerpts

Overview

Naproxen is a widely used nonsteroidal anti-inflammatory drug (NSAID) Used for mild-to-moderate pains, arthritis, and other immune-mediated disorders. Naproxen has relatively low selectivity for cyclooxygenase-2 (COX-2), thereby having decreased risk for cardiovascular (CV) events.

Effects

Naproxen has a propensity to cause ulcers whereas zinc ions are known to possess an anti-ulcer and anti-inflammatory activity. Naproxen, which has an excellent cardiovascular profile, or epidermal growth factor receptor inhibitors may be effective in an adjuvant setting.

Naproxen has an excellent cardiovascular profile, or epidermal growth factor receptor inhibitors may be effective in an adjuvant setting. Naproxen suppositories have been shown to be well tolerated over a 9-week pe.

Actions

Naproxen seems to cause the lowest cardiovascular events of the common NSAIDs other than aspirin. Naproxen may also allow the limitation of extensive fever workups and prolonged empiric antibiotic therapy in these patients.

Treatment

Naproxen was the only treatment to be more effective on all different radiographic subscores than etanercept. Naproxen-treated mice had diminished load-induced bone formation as well as a significant loss in toughness in non-loaded bone.

Toxicity

The available evidence suggests that naproxen sodium is more effective but may cause more adverse events than placebo in the acute treatment of moderate to severe migraine. Prespecified gastrointestinal adverse events were more frequent with Naproxen than with either lumiracoxib dose or placebo.

Pharmacokinetics

Thiamine diphosphate administered intraperitoneally in a dose of 10 mg/kg (one time a day for a week) does not change the analgesic effect of naproxene.

Compound-Compound Interactions

In a double-blind, placebo-controlled study in 125 patients undergoing a cholecystectomy, a comparison was made of the quality of post-operative pain relief. The pharmacokinetics of gabapentin enacarbil were evaluated in healthy adults after administration alone or in combination with naproxen.

Bioavailability

Nonlinear relationship between dose and bioavailability was observed which leads to a less than proportional increase in naproxen concentrations with increasing doses. The controlled release preparation allows more constant plasma levels of Naproxen.

Dosage Studied

This study has been undertaken to develop a controlled-release tablet dosage form of naproxen using ethocel (ethyl cellulose) as the rate-controlling polymer. The direct compression properties and antiulcerogenic activity make chitosan glutamate an optimal carrier for developing fast-action oral solid dosage forms of this drug.