Proteins > Nuclear receptor subfamily 1 group I member 2
Page last updated: 2024-08-07 15:27:36

Nuclear receptor subfamily 1 group I member 2

A nuclear receptor subfamily 1 group I member 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O75469]

Synonyms

Orphan nuclear receptor PAR1;
Orphan nuclear receptor PXR;
Pregnane X receptor;
Steroid and xenobiotic receptor;
SXR

Research

Bioassay Publications (36)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's7 (19.44)29.6817
2010's25 (69.44)24.3611
2020's4 (11.11)2.80

Compounds (86)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
hyperforinHomo sapiens (human)Ki0.027022
gw 3965Homo sapiens (human)Ki2.000011
t0901317Homo sapiens (human)IC500.038633
diethylstilbestrolHomo sapiens (human)IC5014.600011
coumestrolHomo sapiens (human)IC5012.000011
pregna-4,17-diene-3,16-dioneHomo sapiens (human)IC5050.001222
pregna-4,17-diene-3,16-dione, (17z)-isomerHomo sapiens (human)IC500.002411
way 252623Homo sapiens (human)IC501.770011

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
pleconarilHomo sapiens (human)EC500.251211
aa 861Homo sapiens (human)EC5015.966733
bithionolHomo sapiens (human)EC506.800022
chloroxineHomo sapiens (human)EC5039.800011
ciglitazoneHomo sapiens (human)EC509.533333
dimercaprolHomo sapiens (human)EC5027.550022
famprofazoneHomo sapiens (human)EC502.725044
felodipineHomo sapiens (human)EC504.300033
fenbendazoleHomo sapiens (human)EC5010.000011
fentanylHomo sapiens (human)EC5031.600033
flutrimazoleHomo sapiens (human)EC506.100011
haloproginHomo sapiens (human)EC5010.000011
loratadineHomo sapiens (human)EC508.900044
nilvadipineHomo sapiens (human)EC501.547544
nimodipineHomo sapiens (human)EC500.390011
nisoldipineHomo sapiens (human)EC5010.166733
oxatomideHomo sapiens (human)EC504.725044
raloxifeneHomo sapiens (human)EC5011.710011
spiroxatrineHomo sapiens (human)EC5026.866733
vorinostatHomo sapiens (human)EC5030.300022
suraminHomo sapiens (human)EC501.300011
troglitazoneHomo sapiens (human)EC5015.800033
ici 204,219Homo sapiens (human)EC5013.727544
cephaloridineHomo sapiens (human)EC503.200011
thyroxineHomo sapiens (human)EC5055.600022
berlitionHomo sapiens (human)EC502.800011
methylprednisoloneHomo sapiens (human)EC5012.600011
fluorometholoneHomo sapiens (human)EC505.700033
2-tert-butylhydroquinoneHomo sapiens (human)EC507.300022
dronabinolHomo sapiens (human)EC5018.933333
dinalineHomo sapiens (human)EC5028.200011
colforsinHomo sapiens (human)EC506.350044
amlodipine besylateHomo sapiens (human)EC5030.466733
proadifen hydrochlorideHomo sapiens (human)EC5017.266733
bumecainHomo sapiens (human)EC506.025044
spiramideHomo sapiens (human)EC5031.600011
ryodipineHomo sapiens (human)EC506.566733
droxidopaHomo sapiens (human)EC501.602022
fulvestrantHomo sapiens (human)EC501.950011
bosentan anhydrousHomo sapiens (human)EC5011.866733
nbi 27914Homo sapiens (human)EC504.950011
demecolcineHomo sapiens (human)EC5013.350022
testosterone isocaproateHomo sapiens (human)EC5023.666733
ritonavirHomo sapiens (human)EC504.000011
terconazoleHomo sapiens (human)EC5011.500022
tacrolimusHomo sapiens (human)EC505.000011
sr 12813Homo sapiens (human)EC500.193333
5,11-diethyl-5,6,11,12-tetrahydrochrysene-2,8-diolHomo sapiens (human)EC508.600011
t0901317Homo sapiens (human)EC500.068488
epothilone bHomo sapiens (human)EC5022.100022
diclazurilHomo sapiens (human)EC5025.000033
triiodothyronine, reverseHomo sapiens (human)EC5012.600011
zeranolHomo sapiens (human)EC5017.600033
orlistatHomo sapiens (human)EC5014.900022
jhw 015Homo sapiens (human)EC502.640011
alpha-linolenic acidHomo sapiens (human)EC501.251022
sirolimusHomo sapiens (human)EC505.445022
desoximetasoneHomo sapiens (human)EC5031.600011
rimexoloneHomo sapiens (human)EC502.125044
indinavir sulfateHomo sapiens (human)EC5014.950022
lasalocid sodiumHomo sapiens (human)EC5011.700022
rifaximinHomo sapiens (human)EC509.120055
pregna-4,17-diene-3,16-dioneHomo sapiens (human)EC502.500011
lu 208075Homo sapiens (human)EC5031.600022
6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde o-(3,4-dichlorobenzyl)oximeHomo sapiens (human)EC500.990011
trans-delta-tocotrienoloic acidHomo sapiens (human)EC501.300011
trans-delta-tocotrienoloic acidHomo sapiens (human)Kd0.330011
anacetrapibHomo sapiens (human)EC503.900011
tianeptineHomo sapiens (human)EC5025.433333
dabrafenibHomo sapiens (human)EC500.087122
mk-7246Homo sapiens (human)EC5030.000011
bms-911543Homo sapiens (human)EC5050.000011
methacycline monohydrochlorideHomo sapiens (human)EC507.900022
rifampinHomo sapiens (human)EC502.165699
febantelHomo sapiens (human)EC5012.900022
thiamet gHomo sapiens (human)EC5030.000011

Drugs with Other Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
ascofuranoneHomo sapiens (human)MEC3.000011
4-o-carboxymethylascochlorinHomo sapiens (human)MEC30.000011
4-o-methylascochlorinHomo sapiens (human)MEC1.000011
ascochlorinHomo sapiens (human)MEC1.000011
bms 536924Homo sapiens (human)EC201.100011

Enables

This protein enables 9 target(s):

TargetCategoryDefinition
RNA polymerase II transcription regulatory region sequence-specific DNA bindingmolecular functionBinding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II. [GOC:txnOH]
DNA-binding transcription factor activity, RNA polymerase II-specificmolecular functionA DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. [GOC:txnOH-2018]
DNA-binding transcription activator activity, RNA polymerase II-specificmolecular functionA DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II. [GOC:aruk, GOC:txnOH-2018, PMID:20737563, PMID:27145859]
nuclear receptor activitymolecular functionA DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytosol, which leads to its translocation to the nucleus. [GOC:txnOH-2018, PMID:23457262]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
zinc ion bindingmolecular functionBinding to a zinc ion (Zn). [GOC:ai]
nuclear receptor bindingmolecular functionBinding to a nuclear receptor protein. Nuclear receptor proteins are DNA-binding transcription factors which are regulated by binding to a ligand. [PMID:7776974]
sequence-specific double-stranded DNA bindingmolecular functionBinding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding. [GOC:dos, GOC:sl]
RNA polymerase II cis-regulatory region sequence-specific DNA bindingmolecular functionBinding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. [GOC:txnOH-2018]

Located In

This protein is located in 3 target(s):

TargetCategoryDefinition
nucleoplasmcellular componentThat part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
nuclear bodycellular componentExtra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins. [GOC:ma, PMID:10330182]
intermediate filament cytoskeletoncellular componentCytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell. [ISBN:0716731363]

Active In

This protein is active in 1 target(s):

TargetCategoryDefinition
nucleuscellular componentA membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]

Part Of

This protein is part of 2 target(s):

TargetCategoryDefinition
transcription regulator complexcellular componentA protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription. [GOC:jl]
chromatincellular componentThe ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. [GOC:elh, PMID:20404130]

Involved In

This protein is involved in 12 target(s):

TargetCategoryDefinition
regulation of DNA-templated transcriptionbiological processAny process that modulates the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH]
xenobiotic metabolic processbiological processThe chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:cab2, GOC:krc]
signal transductionbiological processThe cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. [GOC:go_curators, GOC:mtg_signaling_feb11]
steroid metabolic processbiological processThe chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. [ISBN:0198547684]
positive regulation of gene expressionbiological processAny process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). [GOC:txnOH-2018]
intracellular receptor signaling pathwaybiological processThe series of molecular signals initiated by a ligand binding to a receptor located within a cell. [GOC:bf, GOC:mah]
xenobiotic catabolic processbiological processThe chemical reactions and pathways resulting in the breakdown of a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:jl, GOC:krc]
xenobiotic transportbiological processThe directed movement of a xenobiotic into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:go_curators, GOC:krc]
positive regulation of DNA-templated transcriptionbiological processAny process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH]
positive regulation of transcription by RNA polymerase IIbiological processAny process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. [GOC:go_curators, GOC:txnOH]
cell differentiationbiological processThe cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. [ISBN:0198506732]
negative regulation of transcription by RNA polymerase IIbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]