Proteins > Serine protease hepsin
Page last updated: 2024-08-08 00:33:43

Serine protease hepsin

A serine protease hepsin that is encoded in the genome of human. [PRO:DNx, UniProtKB:P05981]

Synonyms

EC 3.4.21.106;
Transmembrane protease serine 1

Research

Bioassay Publications (6)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (16.67)29.6817
2010's4 (66.67)24.3611
2020's1 (16.67)2.80

Compounds (7)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
camostatHomo sapiens (human)IC500.023522
camostatHomo sapiens (human)Ki3.439416
gabexateHomo sapiens (human)IC500.383011
nafamostatHomo sapiens (human)IC500.005011
nafamostatHomo sapiens (human)Ki0.000522
leupeptinHomo sapiens (human)Ki0.061011
5-amidinoindoleHomo sapiens (human)Ki500.000011
dabigatranHomo sapiens (human)Ki0.835011
benzamidineHomo sapiens (human)Ki237.500012

Enables

This protein enables 5 target(s):

TargetCategoryDefinition
serine-type endopeptidase activitymolecular functionCatalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
peptidase activitymolecular functionCatalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. [GOC:jl, ISBN:0815332181]
serine-type peptidase activitymolecular functionCatalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). [https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]
serine-type exopeptidase activitymolecular functionCatalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#EXOPEPTIDASE]

Located In

This protein is located in 8 target(s):

TargetCategoryDefinition
endoplasmic reticulum membranecellular componentThe lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah]
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
cell-cell junctioncellular componentA cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects. [GOC:aruk, GOC:bc, GOC:dgh, GOC:hb, GOC:mah, PMID:21422226, PMID:28096264]
cell surfacecellular componentThe external part of the cell wall and/or plasma membrane. [GOC:jl, GOC:mtg_sensu, GOC:sm]
membranecellular componentA lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
apical plasma membranecellular componentThe region of the plasma membrane located at the apical end of the cell. [GOC:curators]
neuronal cell bodycellular componentThe portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. [GOC:go_curators]
extracellular exosomecellular componentA vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]

Involved In

This protein is involved in 17 target(s):

TargetCategoryDefinition
proteolysisbiological processThe hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. [GOC:bf, GOC:mah]
regulation of cell shapebiological processAny process that modulates the surface configuration of a cell. [GOC:dph, GOC:go_curators, GOC:tb]
positive regulation of gene expressionbiological processAny process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). [GOC:txnOH-2018]
negative regulation of epithelial to mesenchymal transitionbiological processAny process that decreases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. [GOC:BHF, GOC:dph, GOC:tb]
positive regulation of plasminogen activationbiological processAny process that increases the rate, frequency or extent of plasminogen activation. Plasminogen activation is the process in which plasminogen is processed to plasmin. [GOC:BHF, GOC:dph, GOC:tb]
positive regulation of cell growthbiological processAny process that activates or increases the frequency, rate, extent or direction of cell growth. [GOC:go_curators]
basement membrane disassemblybiological processThe controlled breakdown of the basement membrane in the context of a normal process such as imaginal disc eversion. [GOC:sart, PMID:17301221]
negative regulation of apoptotic processbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis]
positive regulation by host of viral transcriptionbiological processAny process in which a host organism activates or increases the frequency, rate or extent of viral transcription, the synthesis of either RNA on a template of DNA or DNA on a template of RNA. [GOC:jl]
negative regulation of epithelial cell proliferationbiological processAny process that stops, prevents or reduces the rate or extent of epithelial cell proliferation. [GOC:ai]
detection of mechanical stimulus involved in sensory perception of soundbiological processThe series of events involved in the perception of sound vibration in which the vibration is received and converted into a molecular signal. [GOC:ai]
potassium ion transmembrane transportbiological processA process in which a potassium ion is transported from one side of a membrane to the other. [GOC:mah]
cochlea morphogenesisbiological processThe process in which the cochlea is generated and organized. [GOC:dph, GOC:tb]
response to thyroid hormonebiological processA change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroid hormone stimulus. [GOC:sjw, PMID:9916872]
pilomotor reflexbiological processThe reflex process in which the arrectores pilorum (hair follicle) muscles contract and cause the hair to stand erect. [GOC:BHF, PMID:21335239, Wikipedia:Pilomotor_reflex]
positive regulation of hepatocyte proliferationbiological processAny process that activates or increases the frequency, rate or extent of hepatocyte proliferation. [GOC:BHF, GOC:mah]
positive regulation of thyroid hormone generationbiological processAny process that activates or increases the frequency, rate or extent of thyroid hormone generation. [GOC:obol]