Proteins > G-protein coupled receptor 55

Page last updated: 2024-08-08 00:25:36

G-protein coupled receptor 55

A G-protein coupled receptor 55 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9Y2T6]

Synonyms

Research

Bioassay Publications (10)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	7 (70.00)	24.3611
2020's	3 (30.00)	2.80

Compounds (13)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
dronabinol	Homo sapiens (human)	IC50	14.2000	1	1
abnormal cannabidiol	Homo sapiens (human)	IC50	10.0000	1	1
emindole SB	Homo sapiens (human)	IC50	10.0000	1	1
3-[1-[oxo-(1-phenylcyclopropyl)methyl]-4-piperidinyl]-5-phenyl-1,3,4-oxadiazol-2-one	Homo sapiens (human)	IC50	12.0000	1	1
3-[1-[[1-(4-chlorophenyl)cyclopropyl]-oxomethyl]-4-piperidinyl]-5-phenyl-1,3,4-oxadiazol-2-one	Homo sapiens (human)	IC50	0.6400	1	1

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
etoposide phosphate	Homo sapiens (human)	EC50	20.0000	1	1
dronabinol	Homo sapiens (human)	EC50	10.0000	1	1
abnormal cannabidiol	Homo sapiens (human)	EC50	5.0010	2	2
(6ar-trans)-isomer of tetrahydrocannabivarin 9	Homo sapiens (human)	EC50	0.8800	1	1
sr141716	Homo sapiens (human)	EC50	2.0100	1	1
2,3-dichloro-5,8-dimethoxy-1,4-naphthoquinone	Homo sapiens (human)	EC50	20.0000	1	1
cannabidiol	Homo sapiens (human)	EC50	0.4450	1	1
3-[[4-(2,3-dimethylphenyl)-1-piperazinyl]-oxomethyl]-N,N-dimethyl-4-(1-pyrrolidinyl)benzenesulfonamide	Homo sapiens (human)	EC50	0.2600	1	1
cannabidivarin	Homo sapiens (human)	EC50	0.4000	1	1

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
cp-55,940	Homo sapiens (human)	Kb	1.8900	1	1

Enables

This protein enables 2 target(s):

Target	Category	Definition
G protein-coupled receptor activity	molecular function	Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
cannabinoid receptor activity	molecular function	Combining with a cannabinoid to initiate a change in cell activity. Cannabinoids are a class of diverse chemical compounds that include the endocannabinoids and the phytocannabinoids. [GOC:dph, IUPHAR_GPCR:1279, Wikipedia:Cannabinoid]

Located In

This protein is located in 1 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Involved In

This protein is involved in 8 target(s):

Target	Category	Definition
G protein-coupled receptor signaling pathway	biological process	The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]
activation of phospholipase C activity	biological process	The initiation of the activity of the inactive enzyme phospolipase C as the result of The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand. [GOC:dph, GOC:mah, GOC:tb, PMID:8280098]
positive regulation of Rho protein signal transduction	biological process	Any process that activates or increases the frequency, rate or extent of Rho protein signal transduction. [GOC:bf]
cannabinoid signaling pathway	biological process	A G protein-coupled receptor signaling pathway initiated by a cannabinoid binding to its receptor on the cell surface, and ending with the regulation of a downstream cellular process, e.g. transcription. Cannabinoids are a class of diverse chemical compounds that include the endocannabinoids and the phytocannabinoids. [GOC:bf, GOC:jc, GOC:signaling, Wikipedia:Cannabinoid]
bone resorption	biological process	The process in which specialized cells known as osteoclasts degrade the organic and inorganic portions of bone, and endocytose and transport the degradation products. [GOC:mah, PMID:10968780]
negative regulation of osteoclast differentiation	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of osteoclast differentiation. [GOC:go_curators]
positive regulation of ERK1 and ERK2 cascade	biological process	Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. [GOC:mah]
phospholipase C-activating G protein-coupled receptor signaling pathway	biological process	A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of phospholipase C (PLC) and a subsequent increase in the intracellular concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG). [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]