Equilibrative nucleoside transporter 1

An equilibrative nucleoside transporter 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q99808]

Synonyms

Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter;
Equilibrative NBMPR-sensitive nucleoside transporter;
Nucleoside transporter, es-type;
Solute carrier family 29 member 1

Research

Bioassay Publications (13)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	9 (69.23)	29.6817
2010's	3 (23.08)	24.3611
2020's	1 (7.69)	2.80

Compounds (19)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
dilazep	Homo sapiens (human)	IC50	0.0059	3	2
dipyridamole	Homo sapiens (human)	IC50	0.0537	3	2
dipyridamole	Homo sapiens (human)	Ki	0.0084	3	3
lidoflazine	Homo sapiens (human)	IC50	4.9540	1	1
lidoflazine	Homo sapiens (human)	Ki	0.2799	2	2
uridine	Homo sapiens (human)	IC50	52.0000	1	1
uridine	Homo sapiens (human)	Ki	51.0000	1	1
phlorhizin	Homo sapiens (human)	Ki	1,000.0000	1	1
methylthioinosine	Homo sapiens (human)	IC50	229.0870	1	1
hyaluronoglucosaminidase	Homo sapiens (human)	IC50	36.3078	1	1
gemcitabine	Homo sapiens (human)	IC50	0.1900	1	1
draflazine	Homo sapiens (human)	IC50	0.0053	2	1
adenosine	Homo sapiens (human)	IC50	40.0000	2	1
adenosine	Homo sapiens (human)	Ki	12.0000	1	1
4-nitrobenzylthioinosine	Homo sapiens (human)	IC50	0.0043	5	4
4-nitrobenzylthioinosine	Homo sapiens (human)	Ki	0.0006	8	8
n(6)-benzyladenosine	Homo sapiens (human)	IC50	10.7152	1	1
6-(4-nitrobenzylthio)guanosine	Homo sapiens (human)	IC50	0.0214	1	1
6-(4-nitrobenzylthio)guanosine	Homo sapiens (human)	Ki	0.0011	1	1
5-iodotubercidin	Homo sapiens (human)	IC50	229.0870	1	1
n(6)-phenyladenosine	Homo sapiens (human)	IC50	32.3594	1	1
tecadenoson	Homo sapiens (human)	IC50	12.0000	1	1
tecadenoson	Homo sapiens (human)	Ki	11.0000	1	1
2-hydroxy-5-nitrobenzylthioguanosine	Homo sapiens (human)	IC50	0.0028	1	1
n(6)-cyclopentyladenosine	Homo sapiens (human)	Ki	1.1000	1	1
6-benzylthioinosine	Homo sapiens (human)	IC50	1.6982	1	1
6-benzylthioinosine	Homo sapiens (human)	Ki	0.0365	2	2

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
tecadenoson	Homo sapiens (human)	Km	110.0000	2	2

Enables

This protein enables 9 target(s):

Target	Category	Definition
neurotransmitter transmembrane transporter activity	molecular function	Enables the directed movement of a neurotransmitter into, out of or within a cell, or between cells. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. [GOC:ai, ISBN:0198506732]
nucleoside transmembrane transporter activity	molecular function	Enables the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other. [GOC:ai]
adenine transmembrane transporter activity	molecular function	Enables the transfer of adenine, 6-aminopurine, from one side of a membrane to the other. [GOC:go_curators]
guanine transmembrane transporter activity	molecular function	Enables the transfer of guanine, 2-amino-6-hydroxypurine, from one side of a membrane to the other. [GOC:go_curators]
uracil transmembrane transporter activity	molecular function	Enables the transfer of uracil, 2,4-dioxopyrimidine, from one side of a membrane to the other. [GOC:go_curators]
purine nucleoside transmembrane transporter activity	molecular function	Enables the transfer of a purine nucleoside, a purine base covalently bonded to a ribose or deoxyribose sugar, from one side of a membrane to the other. [GOC:ai]
cytidine transmembrane transporter activity	molecular function	Enables the transfer of cytidine, cytosine riboside, from one side of a membrane to the other. [GOC:go_curators]
uridine transmembrane transporter activity	molecular function	Enables the transfer of uridine, uracil riboside, from one side of a membrane to the other. [GOC:go_curators]
pyrimidine- and adenosine-specific:sodium symporter activity	molecular function	Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: (pyrimidine nucleoside or adenosine)(out) + Na+(out) = (pyrimidine nucleoside or adenosine)(in) + Na+(in). [TC:2.A.41.2.3]

Located In

This protein is located in 6 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
basolateral plasma membrane	cellular component	The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. [GOC:go_curators]
apical plasma membrane	cellular component	The region of the plasma membrane located at the apical end of the cell. [GOC:curators]
presynapse	cellular component	The part of a synapse that is part of the presynaptic cell. [GOC:dos]
postsynapse	cellular component	The part of a synapse that is part of the post-synaptic cell. [GOC:dos]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Involved In

This protein is involved in 26 target(s):

Target	Category	Definition
neurotransmitter uptake	biological process	The directed movement of neurotransmitters into neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters. [ISBN:0123668387]
nucleobase-containing compound metabolic process	biological process	Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. [GOC:ai]
xenobiotic metabolic process	biological process	The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:cab2, GOC:krc]
neurotransmitter transport	biological process	The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. [GOC:ai]
xenobiotic transmembrane transport	biological process	The process in which a xenobiotic, a compound foreign to the organim exposed to it, is transported across a membrane. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:ai, GOC:bf, GOC:krc]
lactation	biological process	The regulated release of milk from the mammary glands and the period of time that a mother lactates to feed her young. [ISBN:0198506732]
nucleobase transport	biological process	The directed movement of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [ISBN:0198506732]
adenine transport	biological process	The directed movement of adenine, 6-aminopurine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:go_curators, ISBN:0198506732]
nucleoside transport	biological process	The directed movement of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]
purine nucleoside transmembrane transport	biological process	The process in which a purine nucleoside is transported across a membrane. A purine nucleoside is a purine base covalently bonded to a ribose or deoxyribose sugar. [GOC:ai, GOC:vw]
cytidine transport	biological process	The directed movement of cytidine, cytosine riboside, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:go_curators]
uridine transmembrane transport	biological process	The directed movement of uridine, uracil riboside, across a lipid bilayer, by means of some agent such as a transporter or pore. [GOC:go_curators]
adenosine transport	biological process	The directed movement of adenosine, adenine riboside, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]
inosine transport	biological process	The directed movement of the purine ribonucleoside inosine, also known as hypoxanthine riboside, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [PMID:19135251]
hypoxanthine transport	biological process	The directed movement of hypoxanthine, 6-hydroxypurine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:sl]
thymine transport	biological process	The directed movement of thymine, 5-methyluracil, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GO:sl]
excitatory postsynaptic potential	biological process	A process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential. [GOC:dph, GOC:ef]
cellular response to glucose stimulus	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus. [GOC:mah]
cellular response to hypoxia	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. [GOC:mah]
pyrimidine-containing compound transmembrane transport	biological process	The process in which a pyrimidine-containing compound is transported across a membrane. A pyrimidine-containing compound is any compound that contains pyrimidine or a formal derivative thereof. [GOC:mah]
transport across blood-brain barrier	biological process	The directed movement of substances (e.g. macromolecules, small molecules, ions) through the blood-brain barrier. [GOC:aruk, GOC:bc, PMID:29377008]
nucleoside transmembrane transport	biological process	The directed movement of nucleoside across a membrane. [GOC:pr, GOC:TermGenie]
guanine transmembrane transport	biological process	The process in which guanine is transported across a membrane. [GO_REF:0000069, GOC:TermGenie, PMID:14998997]
uracil transmembrane transport	biological process	The process in which uracil is transported across a membrane. [GO_REF:0000069, GOC:TermGenie, PMID:8948441]
pyrimidine nucleobase transmembrane transport	biological process	The process in which pyrimidine is transported across a membrane. [GO_REF:0000069, GOC:TermGenie]
purine nucleobase transmembrane transport	biological process	The process in which a purine nucleobase is transported across a membrane. [GO_REF:0000069, GOC:TermGenie]