Page last updated: 2024-08-07 13:42:35
Equilibrative nucleoside transporter 1
An equilibrative nucleoside transporter 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q99808]
Synonyms
Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter;
Equilibrative NBMPR-sensitive nucleoside transporter;
Nucleoside transporter, es-type;
Solute carrier family 29 member 1
Research
Bioassay Publications (13)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 9 (69.23) | 29.6817 |
| 2010's | 3 (23.08) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
Compounds (19)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| dilazep | Homo sapiens (human) | IC50 | 0.0059 | 3 | 2 |
| dipyridamole | Homo sapiens (human) | IC50 | 0.0537 | 3 | 2 |
| dipyridamole | Homo sapiens (human) | Ki | 0.0084 | 3 | 3 |
| lidoflazine | Homo sapiens (human) | IC50 | 4.9540 | 1 | 1 |
| lidoflazine | Homo sapiens (human) | Ki | 0.2799 | 2 | 2 |
| uridine | Homo sapiens (human) | IC50 | 52.0000 | 1 | 1 |
| uridine | Homo sapiens (human) | Ki | 51.0000 | 1 | 1 |
| phlorhizin | Homo sapiens (human) | Ki | 1,000.0000 | 1 | 1 |
| methylthioinosine | Homo sapiens (human) | IC50 | 229.0870 | 1 | 1 |
| hyaluronoglucosaminidase | Homo sapiens (human) | IC50 | 36.3078 | 1 | 1 |
| gemcitabine | Homo sapiens (human) | IC50 | 0.1900 | 1 | 1 |
| draflazine | Homo sapiens (human) | IC50 | 0.0053 | 2 | 1 |
| adenosine | Homo sapiens (human) | IC50 | 40.0000 | 2 | 1 |
| adenosine | Homo sapiens (human) | Ki | 12.0000 | 1 | 1 |
| 4-nitrobenzylthioinosine | Homo sapiens (human) | IC50 | 0.0043 | 5 | 4 |
| 4-nitrobenzylthioinosine | Homo sapiens (human) | Ki | 0.0006 | 8 | 8 |
| n(6)-benzyladenosine | Homo sapiens (human) | IC50 | 10.7152 | 1 | 1 |
| 6-(4-nitrobenzylthio)guanosine | Homo sapiens (human) | IC50 | 0.0214 | 1 | 1 |
| 6-(4-nitrobenzylthio)guanosine | Homo sapiens (human) | Ki | 0.0011 | 1 | 1 |
| 5-iodotubercidin | Homo sapiens (human) | IC50 | 229.0870 | 1 | 1 |
| n(6)-phenyladenosine | Homo sapiens (human) | IC50 | 32.3594 | 1 | 1 |
| tecadenoson | Homo sapiens (human) | IC50 | 12.0000 | 1 | 1 |
| tecadenoson | Homo sapiens (human) | Ki | 11.0000 | 1 | 1 |
| 2-hydroxy-5-nitrobenzylthioguanosine | Homo sapiens (human) | IC50 | 0.0028 | 1 | 1 |
| n(6)-cyclopentyladenosine | Homo sapiens (human) | Ki | 1.1000 | 1 | 1 |
| 6-benzylthioinosine | Homo sapiens (human) | IC50 | 1.6982 | 1 | 1 |
| 6-benzylthioinosine | Homo sapiens (human) | Ki | 0.0365 | 2 | 2 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| tecadenoson | Homo sapiens (human) | Km | 110.0000 | 2 | 2 |
Enables
This protein enables 9 target(s):
| Target | Category | Definition |
|---|---|---|
| neurotransmitter transmembrane transporter activity | molecular function | Enables the directed movement of a neurotransmitter into, out of or within a cell, or between cells. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. [GOC:ai, ISBN:0198506732] |
| nucleoside transmembrane transporter activity | molecular function | Enables the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other. [GOC:ai] |
| adenine transmembrane transporter activity | molecular function | Enables the transfer of adenine, 6-aminopurine, from one side of a membrane to the other. [GOC:go_curators] |
| guanine transmembrane transporter activity | molecular function | Enables the transfer of guanine, 2-amino-6-hydroxypurine, from one side of a membrane to the other. [GOC:go_curators] |
| uracil transmembrane transporter activity | molecular function | Enables the transfer of uracil, 2,4-dioxopyrimidine, from one side of a membrane to the other. [GOC:go_curators] |
| purine nucleoside transmembrane transporter activity | molecular function | Enables the transfer of a purine nucleoside, a purine base covalently bonded to a ribose or deoxyribose sugar, from one side of a membrane to the other. [GOC:ai] |
| cytidine transmembrane transporter activity | molecular function | Enables the transfer of cytidine, cytosine riboside, from one side of a membrane to the other. [GOC:go_curators] |
| uridine transmembrane transporter activity | molecular function | Enables the transfer of uridine, uracil riboside, from one side of a membrane to the other. [GOC:go_curators] |
| pyrimidine- and adenosine-specific:sodium symporter activity | molecular function | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: (pyrimidine nucleoside or adenosine)(out) + Na+(out) = (pyrimidine nucleoside or adenosine)(in) + Na+(in). [TC:2.A.41.2.3] |
Located In
This protein is located in 6 target(s):
| Target | Category | Definition |
|---|---|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
| basolateral plasma membrane | cellular component | The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. [GOC:go_curators] |
| apical plasma membrane | cellular component | The region of the plasma membrane located at the apical end of the cell. [GOC:curators] |
| presynapse | cellular component | The part of a synapse that is part of the presynaptic cell. [GOC:dos] |
| postsynapse | cellular component | The part of a synapse that is part of the post-synaptic cell. [GOC:dos] |
Active In
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
Involved In
This protein is involved in 26 target(s):
| Target | Category | Definition |
|---|---|---|
| neurotransmitter uptake | biological process | The directed movement of neurotransmitters into neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters. [ISBN:0123668387] |
| nucleobase-containing compound metabolic process | biological process | Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. [GOC:ai] |
| xenobiotic metabolic process | biological process | The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:cab2, GOC:krc] |
| neurotransmitter transport | biological process | The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. [GOC:ai] |
| xenobiotic transmembrane transport | biological process | The process in which a xenobiotic, a compound foreign to the organim exposed to it, is transported across a membrane. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:ai, GOC:bf, GOC:krc] |
| lactation | biological process | The regulated release of milk from the mammary glands and the period of time that a mother lactates to feed her young. [ISBN:0198506732] |
| nucleobase transport | biological process | The directed movement of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [ISBN:0198506732] |
| adenine transport | biological process | The directed movement of adenine, 6-aminopurine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:go_curators, ISBN:0198506732] |
| nucleoside transport | biological process | The directed movement of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai] |
| purine nucleoside transmembrane transport | biological process | The process in which a purine nucleoside is transported across a membrane. A purine nucleoside is a purine base covalently bonded to a ribose or deoxyribose sugar. [GOC:ai, GOC:vw] |
| cytidine transport | biological process | The directed movement of cytidine, cytosine riboside, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:go_curators] |
| uridine transmembrane transport | biological process | The directed movement of uridine, uracil riboside, across a lipid bilayer, by means of some agent such as a transporter or pore. [GOC:go_curators] |
| adenosine transport | biological process | The directed movement of adenosine, adenine riboside, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah] |
| inosine transport | biological process | The directed movement of the purine ribonucleoside inosine, also known as hypoxanthine riboside, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [PMID:19135251] |
| hypoxanthine transport | biological process | The directed movement of hypoxanthine, 6-hydroxypurine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:sl] |
| thymine transport | biological process | The directed movement of thymine, 5-methyluracil, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GO:sl] |
| excitatory postsynaptic potential | biological process | A process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential. [GOC:dph, GOC:ef] |
| cellular response to glucose stimulus | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus. [GOC:mah] |
| cellular response to hypoxia | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. [GOC:mah] |
| pyrimidine-containing compound transmembrane transport | biological process | The process in which a pyrimidine-containing compound is transported across a membrane. A pyrimidine-containing compound is any compound that contains pyrimidine or a formal derivative thereof. [GOC:mah] |
| transport across blood-brain barrier | biological process | The directed movement of substances (e.g. macromolecules, small molecules, ions) through the blood-brain barrier. [GOC:aruk, GOC:bc, PMID:29377008] |
| nucleoside transmembrane transport | biological process | The directed movement of nucleoside across a membrane. [GOC:pr, GOC:TermGenie] |
| guanine transmembrane transport | biological process | The process in which guanine is transported across a membrane. [GO_REF:0000069, GOC:TermGenie, PMID:14998997] |
| uracil transmembrane transport | biological process | The process in which uracil is transported across a membrane. [GO_REF:0000069, GOC:TermGenie, PMID:8948441] |
| pyrimidine nucleobase transmembrane transport | biological process | The process in which pyrimidine is transported across a membrane. [GO_REF:0000069, GOC:TermGenie] |
| purine nucleobase transmembrane transport | biological process | The process in which a purine nucleobase is transported across a membrane. [GO_REF:0000069, GOC:TermGenie] |