1-1-diphenyl-2-picrylhydrazyl has been researched along with Necrosis* in 3 studies
3 other study(ies) available for 1-1-diphenyl-2-picrylhydrazyl and Necrosis
| Article | Year |
|---|---|
Fabrication of nanofiber coated with l-arginine via electrospinning technique: a novel nanomatrix to counter oxidative stress under crosstalk of co-cultured fibroblasts and satellite cells.
Topics: Animals; Apoptosis; Arginine; Biphenyl Compounds; Caspase 3; Cattle; Cell Membrane; Cell Shape; Coculture Techniques; Comet Assay; Enzyme Activation; Fibroblasts; Free Radical Scavengers; Mitochondria; Nanofibers; Nanotechnology; Necrosis; Oxidative Stress; Picrates; Polyurethanes; Reactive Oxygen Species; Satellite Cells, Skeletal Muscle; Staining and Labeling | 2018 |
Citrus medica "Otroj": attenuates oxidative stress and cardiac dysrhythmia in isoproterenol-induced cardiomyopathy in rats.
Citrus medica L. commonly known as Otroj, is an important medicinal plant reputed for its nutritious and therapeutic uses. The present work was undertaken to investigate the protective effect of the ethanolic extract of otroj (EEOT) against isoproterenol (ISO)-induced cardiotoxicity in rats. In addition, the antioxidant activity and the phenolic and flavonoidal contents were determined. Rats were administered EETO (250 and 500 mg/kg) or vehicle orally for 15 days along with ISO (85 mg/kg, s.c.) on the 14th and 15th day. ISO induced cardiac dysfunction, increased lipid peroxidation and alteration of myocyte-injury specific marker enzymes. ISO also showed an increase in levels of plasma cholesterol, triglycerides (TG), LDL-C, and VLDL-C. Moreover, the histological investigations showed myocardial necrosis and inflammation. EETO treatment brought the above parameters towards normal level. Moreover, in vitro DPPH radical scavenging and β-carotene-linoleic acid tests of the EEOT exhibited a notable antioxidant activity in both assays used. In addition, histopathological examination reconfirmed the protective effects of EEOT. Thus, the present study reveals that C. medica alleviates myocardial damage in ISO-induced cardiac injury and demonstrates cardioprotective potential which could be attributed to its potent antioxidant and free radical scavenging activity. Topics: Animals; Antioxidants; Biomarkers; Biphenyl Compounds; Cardiomyopathies; Citrus; Female; Flavonoids; Inflammation; Isoproterenol; Lipid Peroxidation; Lipids; Male; Myocardium; Necrosis; Oxidative Stress; Phenols; Phytotherapy; Picrates; Plant Extracts; Rats; Rats, Wistar; Tachycardia | 2013 |
Free radical scavenging and hepatoprotective potential of Ficus microcarpa L. fil. bark extracts.
Successive extracts of Ficus microcarpa L. fil. bark (FMB) were tested for antioxidant and hepatoprotective activity against carbon tetrachloride- and paracetamol-induced hepatotoxicities in rats. The ethyl acetate extract of FMB exhibited significant antioxidant and hepatoprotective activity by reducing carbon tetrachloride- and paracetamol-induced changes in biochemical parameters as evidenced by enzymatic and histological examination. Pretreatment with ethyl acetate extract of FMB significantly shortened the duration of pentobarbitone-induced necrosis in mice, indicating its hepatoprotective potential. Phytochemical studies confirmed the presence of the phenolic compound, catechin, in FMB, which may interfere with free-radical formation and may account for its significant hepatoprotective effects. The present study thus provides a scientific rationale for the traditional use of this plant in the management of liver disorders. Topics: Animals; Biphenyl Compounds; Carbon Tetrachloride; Ficus; Free Radical Scavengers; Liver; Male; Mice; Necrosis; Pentobarbital; Picrates; Plant Bark; Plant Extracts; Rats; Rats, Wistar | 2011 |