6-phosphogluconate dehydrogenase, decarboxylating

A 6-phosphogluconate dehydrogenase, decarboxylating that is encoded in the genome of human. [PRO:DNx, UniProtKB:P52209]

EC 1.1.1.44

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
furosemide	Homo sapiens (human)	Ki	127.0000	1	1
ketotifen	Homo sapiens (human)	Ki	8.3000	1	1
metoclopramide	Homo sapiens (human)	Ki	2,111.3000	1	1
epigallocatechin gallate	Homo sapiens (human)	IC50	0.7200	1	1
epicatechin	Homo sapiens (human)	IC50	1,000.0000	1	1
gallocatechol	Homo sapiens (human)	IC50	1,000.0000	1	1
(-)-catechin	Homo sapiens (human)	IC50	1,000.0000	1	1
epicatechin gallate	Homo sapiens (human)	IC50	0.2100	1	1
methotrexate	Homo sapiens (human)	Ki	136.7000	1	1
(-)-gallocatechin gallate	Homo sapiens (human)	IC50	1.4500	1	1
4-phospho-d-erythronohydroxamic acid	Homo sapiens (human)	Ki	1.2750	2	2
4-phosphoerythronate	Homo sapiens (human)	Ki	5.4150	2	2
(-)-catechin-3-O-gallate	Homo sapiens (human)	IC50	1.2800	1	1
mobic	Homo sapiens (human)	Ki	37.3000	1	3

This protein enables 2 target(s):

Target	Category	Definition
phosphogluconate dehydrogenase (decarboxylating) activity	molecular function	Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+. [EC:1.1.1.44]
NADP binding	molecular function	Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. [GOC:ai]

This protein is located in 3 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
extracellular exosome	cellular component	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]

This protein is active in 1 target(s):

Target	Category	Definition
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

This protein is involved in 4 target(s):

Target	Category	Definition
pentose-phosphate shunt	biological process	The metabolic process in which glucose-6-phosphate is oxidized to form carbon dioxide (CO2) and ribulose 5-phosphate, coupled to reduction of NADP+ to NADPH; ribulose 5-P then enters a series of reactions that can yield biosynthetic precursors (ribose-5-phosphate and erythrose-4-phosphate) and glycolytic intermediates (fructose-6-phosphate and glyceraldehyde-3-phosphate). [GOC:pde, ISBN:0198506732, MetaCyc:PENTOSE-P-PWY]
pentose-phosphate shunt, oxidative branch	biological process	The branch of the pentose-phosphate shunt which involves the oxidation of glucose 6-P and produces ribulose 5-P, reduced NADP+ and carbon dioxide (CO2). [ISBN:0198506732, MetaCyc:OXIDATIVEPENT-PWY]
pentose biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of a pentose, any monosaccharide with a chain of five carbon atoms in the molecule. [ISBN:0198506732]
D-gluconate catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of D-gluconate, the anion of D-gluconic acid, the aldonic acid derived from glucose. [ISBN:0198506732]