A protein that is a translation product of the lef gene in Bacillus anthracis. [PRO:DNx, UniProtKB:P15917]
LF;
EC 3.4.24.83;
Anthrax lethal toxin endopeptidase component
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (58.33) | 29.6817 |
| 2010's | 4 (33.33) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| pyrithione | Bacillus anthracis | IC50 | 5,000.0000 | 1 | 1 |
| acetohydroxamic acid | Bacillus anthracis | IC50 | 11,400.0000 | 1 | 1 |
| amiodarone | Bacillus anthracis | IC50 | 3.5000 | 1 | 1 |
| bepridil | Bacillus anthracis | IC50 | 4.8000 | 1 | 1 |
| bisindolylmaleimide i | Bacillus anthracis | IC50 | 1.5000 | 1 | 1 |
| framycetin | Bacillus anthracis | Ki | 0.2535 | 2 | 2 |
| 4',6-bis(2'imidazolinyl-4',5'-h)-2-phenylindole | Bacillus anthracis | IC50 | 49.0000 | 1 | 1 |
| epigallocatechin gallate | Bacillus anthracis | IC50 | 0.0970 | 1 | 1 |
| 5,5'-methylenedisalicylic acid | Bacillus anthracis | IC50 | 3.0000 | 2 | 2 |
| 5,5'-methylenedisalicylic acid | Bacillus anthracis | Ki | 3.2333 | 3 | 3 |
| 1-hydroxy-2(1h)-pyridinone | Bacillus anthracis | IC50 | 5,000.0000 | 1 | 1 |
| aminoquinuride | Bacillus anthracis | IC50 | 3.2000 | 1 | 1 |
| aminoquinuride | Bacillus anthracis | Ki | 0.5000 | 1 | 1 |
| neamine | Bacillus anthracis | Ki | 42.9000 | 3 | 3 |
| cgs 27023a | Bacillus anthracis | IC50 | 1.2000 | 1 | 1 |
| n-oleoyldopamine | Bacillus anthracis | IC50 | 15.0000 | 1 | 1 |
| n-oleoyldopamine | Bacillus anthracis | Ki | 3.0000 | 1 | 1 |
| n,n-dimethylsphingenine | Bacillus anthracis | IC50 | 2.3000 | 1 | 1 |
| leukadherin-1 | Bacillus anthracis | IC50 | 6.0000 | 1 | 1 |