Estrogen receptor beta

An estrogen receptor beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q92731]

Synonyms

ER-beta;
Nuclear receptor subfamily 3 group A member 2

Research

Bioassay Publications (142)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	13 (9.15)	18.2507
2000's	83 (58.45)	29.6817
2010's	35 (24.65)	24.3611
2020's	11 (7.75)	2.80

Compounds (93)

Drugs with Potency Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
mifepristone	Homo sapiens (human)	Potency	1.0000	1	1
onapristone	Homo sapiens (human)	Potency	1.0000	1	1

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
naringenin	Homo sapiens (human)	IC50	42.8875	1	2
stallimycin	Homo sapiens (human)	IC50	0.0200	1	1
emodin	Homo sapiens (human)	IC50	5.2000	1	1
emodin	Homo sapiens (human)	Ki	1.5000	1	1
raloxifene	Homo sapiens (human)	IC50	0.3051	40	43
raloxifene	Homo sapiens (human)	Ki	0.0065	7	8
prednisolone	Homo sapiens (human)	IC50	55.0000	2	2
prednisolone	Homo sapiens (human)	Ki	1.0000	1	1
spironolactone	Homo sapiens (human)	IC50	46.6667	3	3
estrone	Homo sapiens (human)	IC50	0.3743	5	6
ethinyl estradiol	Homo sapiens (human)	IC50	0.0129	2	2
medroxyprogesterone acetate	Homo sapiens (human)	IC50	0.9240	2	2
bisphenol a	Homo sapiens (human)	IC50	0.8700	1	1
2,6-dihydroxyanthraquinone	Homo sapiens (human)	IC50	2.4000	1	1
2,6-dihydroxyanthraquinone	Homo sapiens (human)	Ki	0.6900	1	1
androstenediol	Homo sapiens (human)	IC50	0.0100	2	2
4-cumylphenol	Homo sapiens (human)	IC50	13.0000	1	1
levormeloxifene	Homo sapiens (human)	IC50	0.0730	1	1
raloxifene hydrochloride	Homo sapiens (human)	IC50	0.1297	5	5
mifepristone	Homo sapiens (human)	IC50	3.5140	4	4
mifepristone	Homo sapiens (human)	Ki	4.5420	3	3
4-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol	Homo sapiens (human)	IC50	0.0527	14	14
4-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol	Homo sapiens (human)	Ki	0.0009	7	7
alfatradiol	Homo sapiens (human)	IC50	0.9000	2	2
2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	Homo sapiens (human)	IC50	0.0504	2	2
equol	Homo sapiens (human)	IC50	5.5710	1	1
anthraglycoside b	Homo sapiens (human)	IC50	62.0000	1	1
anthraglycoside b	Homo sapiens (human)	Ki	18.0000	1	1
effusol	Homo sapiens (human)	IC50	0.0120	1	1
fulvestrant	Homo sapiens (human)	IC50	0.0104	11	11
fulvestrant	Homo sapiens (human)	Ki	0.0032	3	3
ici 164384	Homo sapiens (human)	Ki	0.0029	3	3
ly 117018	Homo sapiens (human)	IC50	0.1200	1	1
zk 119010	Homo sapiens (human)	IC50	0.2420	1	1
bazedoxifene	Homo sapiens (human)	IC50	0.0444	2	2
ly 353381	Homo sapiens (human)	IC50	0.0985	3	4
lasofoxifene	Homo sapiens (human)	IC50	0.0077	8	10
1,1-bis(4-hydroxyphenyl)cyclohexane	Homo sapiens (human)	IC50	0.5600	1	1
naringenin	Homo sapiens (human)	IC50	13.4730	1	1
davidigenin	Homo sapiens (human)	IC50	1,000.0000	1	1
eplerenone	Homo sapiens (human)	IC50	60.0000	2	2
fluticasone propionate	Homo sapiens (human)	IC50	10.0000	1	1
diethylstilbestrol	Homo sapiens (human)	IC50	0.1588	4	4
diethylstilbestrol	Homo sapiens (human)	Ki	0.0003	3	3
afimoxifene	Homo sapiens (human)	IC50	0.0102	3	4
8-prenylnaringenin	Homo sapiens (human)	IC50	0.0625	1	2
8-isopentenylnaringenin	Homo sapiens (human)	IC50	0.0680	1	1
1,1-Bis(4-hydroxyphenyl)ethane	Homo sapiens (human)	IC50	2.4000	1	1
isoliquiritigenin	Homo sapiens (human)	IC50	0.2690	1	1
erb 041	Homo sapiens (human)	IC50	0.0050	2	2
tamoxifen citrate	Homo sapiens (human)	IC50	0.0050	1	1
tamoxifen	Homo sapiens (human)	IC50	1.2790	22	22
tamoxifen	Homo sapiens (human)	Ki	0.0510	4	4
idoxifene	Homo sapiens (human)	IC50	0.0075	1	1
N-[2-(2-methyl-1-indolyl)ethyl]benzamide	Homo sapiens (human)	IC50	32.7000	1	0
apigenin	Homo sapiens (human)	IC50	7.0650	2	2
genistein	Homo sapiens (human)	IC50	2.0569	24	26
genistein	Homo sapiens (human)	Ki	0.0123	2	1
pulmicort	Homo sapiens (human)	IC50	10.0000	1	1
coumestrol	Homo sapiens (human)	IC50	0.0131	2	3
daidzein	Homo sapiens (human)	IC50	1.6568	5	6
daidzein	Homo sapiens (human)	Ki	0.3000	1	1
afimoxifene	Homo sapiens (human)	IC50	0.0036	1	1
gw 5638	Homo sapiens (human)	IC50	0.0560	1	1
onapristone	Homo sapiens (human)	IC50	1.0000	2	2
onapristone	Homo sapiens (human)	Ki	0.0200	1	1
broussonin a	Homo sapiens (human)	IC50	1.8000	1	1
ly2066948	Homo sapiens (human)	Ki	0.0011	2	3
afimoxifene	Homo sapiens (human)	IC50	0.0013	2	2
dehydrodiconiferyl alcohol	Homo sapiens (human)	IC50	0.2865	1	1
way 202196	Homo sapiens (human)	IC50	0.0027	1	1
era-923	Homo sapiens (human)	IC50	0.0400	1	1
pregna-4,17-diene-3,16-dione	Homo sapiens (human)	IC50	5.0000	1	1
pregna-4,17-diene-3,16-dione	Homo sapiens (human)	Ki	5.0000	1	1
pregna-4,17-diene-3,16-dione, (17z)-isomer	Homo sapiens (human)	IC50	5.0000	1	1
pregna-4,17-diene-3,16-dione, (17z)-isomer	Homo sapiens (human)	Ki	5.0000	1	1
gw 7604	Homo sapiens (human)	IC50	0.0405	4	4
gw 7604	Homo sapiens (human)	Ki	0.0100	1	1
fluticasone furoate	Homo sapiens (human)	IC50	5.0000	1	1
em 800	Homo sapiens (human)	IC50	0.0007	2	2
em 800	Homo sapiens (human)	Ki	0.0040	4	4
6-(3-hydroxyphenyl)-2-naphthol	Homo sapiens (human)	IC50	0.0300	1	1
erteberel	Homo sapiens (human)	Ki	0.0012	9	14
ly3201	Homo sapiens (human)	Ki	0.0031	4	6
4-(2-phenyl-5,7-bis(trifluoromethyl)pyrazolo(1,5-a)pyrimidin-3-yl)phenol	Homo sapiens (human)	Ki	0.8333	2	3
y134 compound	Homo sapiens (human)	IC50	0.0339	2	2
moxestrol	Homo sapiens (human)	IC50	0.0027	2	2
nitd 609	Homo sapiens (human)	IC50	30.0000	1	1
way 200070	Homo sapiens (human)	IC50	0.0018	2	3
way-169916	Homo sapiens (human)	IC50	0.1060	1	1

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
raloxifene	Homo sapiens (human)	EC50	0.2600	1	1
spironolactone	Homo sapiens (human)	EC50	3.3000	1	1
estrone	Homo sapiens (human)	EC50	0.1632	9	9
ethinyl estradiol	Homo sapiens (human)	EC50	0.0035	3	3
medroxyprogesterone acetate	Homo sapiens (human)	EC50	0.9240	1	1
bisphenol a	Homo sapiens (human)	EC50	0.9285	2	2
ethyl-p-hydroxybenzoate	Homo sapiens (human)	EC50	1.8600	1	1
androstenediol	Homo sapiens (human)	EC50	0.0058	2	2
4,4'-bisphenol f	Homo sapiens (human)	EC50	1.9000	1	1
mifepristone	Homo sapiens (human)	EC50	10.0000	1	1
1,1-bis(4-hydroxyphenyl)-2-phenylbut-1-ene	Homo sapiens (human)	EC50	0.3069	3	3
4-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol	Homo sapiens (human)	EC50	0.0008	1	1
taleranol	Homo sapiens (human)	EC50	0.1460	1	2
6-ketoestradiol	Homo sapiens (human)	EC50	0.0382	1	0
alfatradiol	Homo sapiens (human)	EC50	0.6172	2	2
2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	Homo sapiens (human)	Kd	0.0112	1	1
2,3-bis(4-hydroxyphenyl)-propionitrile	Homo sapiens (human)	EC50	115.7183	14	14
Zearalanone	Homo sapiens (human)	EC50	0.3490	1	2
liquiritigenin	Homo sapiens (human)	EC50	0.0365	1	1
estrone-3-o-sulfamate	Homo sapiens (human)	EC50	3.7000	1	1
2-hydroxyestradiol	Homo sapiens (human)	EC50	1.0820	2	2
eplerenone	Homo sapiens (human)	EC50	20.0000	1	1
diethylstilbestrol	Homo sapiens (human)	EC50	0.0045	2	2
8-prenylnaringenin	Homo sapiens (human)	EC50	0.0050	1	1
1,1-Bis(4-hydroxyphenyl)ethane	Homo sapiens (human)	EC50	1.3950	1	1
trans-4-coumaric acid	Homo sapiens (human)	EC50	4.8900	1	1
2,4,4'-trihydroxydeoxybenzoin	Homo sapiens (human)	EC50	0.5000	1	1
tamoxifen	Homo sapiens (human)	EC50	0.9808	3	5
zeranol	Homo sapiens (human)	EC50	0.0240	1	1
genistein	Homo sapiens (human)	EC50	0.1635	9	9
zearalenone	Homo sapiens (human)	EC50	0.1100	1	1
4-hydroxyestradiol	Homo sapiens (human)	EC50	0.2857	2	2
broussonin a	Homo sapiens (human)	EC50	0.5300	1	1
1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3h-cyclopenta(c)quinolin-8-yl)ethanone	Homo sapiens (human)	EC50	0.1838	1	0
4-[(3aR,4S,9bS)-8-[(4-methoxyphenyl)sulfamoyl]-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl]benzoic acid	Homo sapiens (human)	EC50	2.2770	1	0
2-methyl-5-[(2-oxo-1H-benzo[cd]indol-6-yl)sulfonylamino]-3-benzofurancarboxylic acid butyl ester	Homo sapiens (human)	EC50	0.0837	1	0
licoflavone c	Homo sapiens (human)	EC50	0.0035	1	1
erteberel	Homo sapiens (human)	EC50	0.0007	1	1

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
raloxifene	Homo sapiens (human)	Ka	0.0412	1	1
raloxifene	Homo sapiens (human)	Relative binding affinity	0.0040	1	1
estrone	Homo sapiens (human)	ED50	0.0700	1	1
estrone-3-o-sulfamate	Homo sapiens (human)	ED50	3.7000	1	1
afimoxifene	Homo sapiens (human)	Ka	0.0020	1	1
ascochlorin	Homo sapiens (human)	MEC	1.0000	1	1

Enables

This protein enables 12 target(s):

Target	Category	Definition
RNA polymerase II cis-regulatory region sequence-specific DNA binding	molecular function	Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. [GOC:txnOH-2018]
DNA-binding transcription factor activity, RNA polymerase II-specific	molecular function	A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. [GOC:txnOH-2018]
DNA binding	molecular function	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
nuclear steroid receptor activity	molecular function	Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function. [GOC:signaling, PMID:14708019]
nuclear receptor activity	molecular function	A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytosol, which leads to its translocation to the nucleus. [GOC:txnOH-2018, PMID:23457262]
steroid binding	molecular function	Binding to a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene. [GOC:jl, ISBN:0198506732]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
zinc ion binding	molecular function	Binding to a zinc ion (Zn). [GOC:ai]
enzyme binding	molecular function	Binding to an enzyme, a protein with catalytic activity. [GOC:jl]
nuclear estrogen receptor activity	molecular function	Combining with estrogen and transmitting the signal within the cell to trigger a change in cell activity or function. [GOC:signaling, PMID:17615392]
estrogen response element binding	molecular function	Binding to an estrogen response element (ERE), a conserved sequence found in the promoters of genes whose expression is regulated in response to estrogen. [GOC:ecd, PMID:15036253, PMID:17975005]
receptor antagonist activity	molecular function	The activity of a gene product that interacts with a receptor to decrease the ability of the receptor agonist to bind and activate the receptor. [GOC:ceb, ISBN:0198506732]

Located In

This protein is located in 4 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
mitochondrion	cellular component	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732]
intracellular membrane-bounded organelle	cellular component	Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. [GOC:go_curators]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]

Part Of

This protein is part of 1 target(s):

Target	Category	Definition
chromatin	cellular component	The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. [GOC:elh, PMID:20404130]

Involved In

This protein is involved in 11 target(s):

Target	Category	Definition
negative regulation of transcription by RNA polymerase II	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]
regulation of DNA-templated transcription	biological process	Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH]
signal transduction	biological process	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. [GOC:go_curators, GOC:mtg_signaling_feb11]
cell-cell signaling	biological process	Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions. [GOC:dos, GOC:mah]
negative regulation of cell growth	biological process	Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth. [GOC:go_curators]
intracellular estrogen receptor signaling pathway	biological process	The series of molecular signals initiated by estrogen binding to its nuclear receptor inside the cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mah, GOC:signaling]
positive regulation of DNA-templated transcription	biological process	Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH]
positive regulation of DNA-binding transcription factor activity	biological process	Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription. [GOC:ai]
cellular response to estradiol stimulus	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen. [GOC:mah]
regulation of transcription by RNA polymerase II	biological process	Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]
cellular response to estrogen stimulus	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics. [GOC:mah]