cloxacillin profile

Cloxacillin: A semi-synthetic antibiotic that is a chlorinated derivative of OXACILLIN. [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

cloxacillin : A semisynthetic penicillin antibiotic carrying a 3-(2-chlorophenyl)-5-methylisoxazole-4-carboxamido group at position 6. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

ID Source	ID
PubMed CID	6098
CHEMBL ID	891
CHEBI ID	49566
SCHEMBL ID	2953
MeSH ID	M0004647

Synonym
BRD-K01244426-236-05-5
DIVK1C_000736
KBIO1_000736
(2s,5r,6r)-6-({[3-(2-chlorophenyl)-5-methylisoxazol-4-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
SPECTRUM_001345
IDI1_000736
SPECTRUM5_000783
cloxacillin (inn)
D07733
mcipc
orbenin (tn)
PRESTWICK2_000186
BSPBIO_002059
PRESTWICK3_000186
C06923
61-72-3
cloxacillin
4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[[3-(2-chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-, (2s,5r,6r)-
tegopen (sodium monohydrate)
brl-1621 (sodium monohydrate)
cloxapen (sodium monohydrate)
(2s,5r,6r)-6-[[3-(2-chlorophenyl)-5-methyl-isoxazole-4-carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
p-25 (sodium monohydrate)
6-(3-(o-chlorophenyl)-5-methyl-4-isoxazolecarboxamido)penicillanic acid
(3-(o-chlorophenyl)-5-methyl-4-isoxazolyl)penicillin
DB01147
BPBIO1_000123
einecs 200-514-7
brl 1621
cloxacillin [inn:ban]
cloxacilina [inn-spanish]
4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(3-(o-chlorophenyl)-s-methyl-4-isoxazolecarboxamido)-3,3-dimethyl-7-oxo-
syntarpen
clossacillina [dcit]
4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(3-(o-chlorophenyl)-5-methyl-4-isoxazolecarboxamido)-3,3-dimethyl-7-oxo-
hsdb 3042
cloxacilline [inn-french]
methocillin s
cloxacillinum [inn-latin]
4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(((3-(2-chlorophenyl)-5-methyl-4-isoxazolyl)carbonyl)amino)-3,3-dimethyl-7-oxo-, (2s-(2alpha,5alpha,6beta))-
6-(((3-(2-chlorophenyl)-5-methyl-4-isoxazolyl)carbonyl)amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid
methylchlorphenylisoxazoryl-penicillin
chloroxacillin
KBIOGR_000852
KBIOSS_001825
KBIO2_001825
KBIO2_006961
KBIO3_001279
KBIO2_004393
SPECTRUM3_000360
NINDS_000736
SPBIO_001065
SPECTRUM2_001143
SPECTRUM4_000296
SPBIO_002032
PRESTWICK1_000186
PRESTWICK0_000186
BSPBIO_000111
CHEBI:49566 ,
cloxacilline
cloxacilina
cloxacillinum
spectrum 001345
CHEMBL891 ,
(2s,5r,6r)-6-[[3-(2-chlorophenyl)-5-methyl-1,2-oxazole-4-carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
(2s,5r,6r)-6-(3-(2-chlorophenyl)-5-methylisoxazole-4-carboxamido)-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid
6-{[3-(2-chloro-phenyl)-5-methyl-isoxazole-4-carbonyl]-amino}-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid
(2s,5r,6r)-6-{[3-(2-chloro-phenyl)-5-methyl-isoxazole-4-carbonyl]-amino}-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid
bdbm50022788
clossacillina
(2s,5r,6r)-6-[3-(2-chlorophenyl)-5-methyl-1,2-oxazole-4-amido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
unii-o6x5qgc2vb
o6x5qgc2vb ,
cloxacillin [vandf]
cloxacillin [hsdb]
oxacillin sodium monohydrate impurity e [ep impurity]
cloxacillin [inn]
cloxacillin [mart.]
cloxacillin [who-dd]
cloxacillin [mi]
EPITOPE ID:120363
SCHEMBL2953
W-105105
6-(3-o-chlorophenyl-5-methylisoxazol-4-ylamido)penicillanic acid
DTXSID5022853 ,
6-(3-o-chlorophenyl-5-methylisoxazol-4-ylamido) penicillanic acid
brl1621
gtpl11126
SBI-0051319.P003
cloxacillinna
(2s,5r,6r)-6-(3-(2-chlorophenyl)-5-methylisoxazole-4-carboxamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
BCP24144
Q422219
cloxacillin ,(s)
BRD-K01244426-236-08-9
HY-B0466A
CS-0028411
cloxacilline (inn-french)
j01cf02
cloxacillinum natricum
cloxacillin (mart.)
2,2-dimethyl-6beta-(((5-methyl-3-(2-chlorophenyl)isoxazol-4-yl)carbonyl)amino)penam-3alpha-carboxylic acid
dtxcid502853
cloxacilina (inn-spanish)
cloxacillina
cloxacillinum (inn-latin)
(2s,5r,6r)-6-(((3-(2-chlorophenyl)-5-methylisoxazol-4-yl)carbonyl)amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid
EN300-708784
cloxacillin 1000 microg/ml in acetonitrile

Excerpt	Reference
"Cloxacillin has a narrow microbiological spectrum."	( Bru, JP; Garraffo, R, 2012)
"Cloxacillin has a narrow microbiological spectrum."	( Bru, JP; Garraffo, R, 2012)
"Cloxacillin sodium has been shown to form charge transfer (CT) complexes of 1:1 stoichiometry with a number of electron acceptors in 50% (v/v) aqueous ethanol medium. "	( Mukherjee, AK; Roy, DK; Saha, A, 2005)
"Cloxacillin sodium has been shown to form a charge transfer complex of 2:1 stoichiometry with riboflavin (Vitamin B(2)) in aqueous ethanol medium. "	( Mukherjee, AK; Roy, DK; Saha, A, 2006)
"Dicloxacillin has lower values of the standard Gibbs energies of adsorption than does cloxacillin, which gives this drug a more marked escaping tendency from the aqueous environment to the air-water monolayer."	( Antelo, LT; Barbosa, S; Mosquera, V; Taboada, P, 2006)

Excerpt	Reference
"Dicloxacillin has lower values of the standard Gibbs energies of adsorption than does cloxacillin, which gives this drug a more marked escaping tendency from the aqueous environment to the air-water monolayer."	( Antelo, LT; Barbosa, S; Mosquera, V; Taboada, P, 2006)

Excerpt	Reference
"Cloxacillin pretreatment was significantly more effective than nafcillin or amoxycillin in some tests and equally effective in others."	( Anderson, JC; Craven, N; Williams, MR, 1982)
"Cloxacillin treatment was continued for 6 months, initially parenterally and later orally."	( Brom, AG; Dirksen, T; Nubé, M; Thompson, J, 1976)
"Treatment with cloxacillin 8 to 10 wk before calving resulted in a lower prevalence of culture-positive milk samples at calving and lower quarter milk SCC in early lactation [30,000 +/- 4,600 (standard deviation) cells/mL in treated heifers versus 40,000 +/- 4,600 cells/mL in control heifers], and was associated with lower average test-day SCC (55,000 +/- 1,400 cells/mL in treated heifers versus 71,000 +/- 1,500 cells/mL in control heifers) and lower incidence of clinical mastitis throughout lactation."	( Barkema, HW; De Vliegher, S; Lam, TJ; Sampimon, OC; Sol, J, 2009)
"Treatment with cloxacillin, administered parenterally, achieved results similar to those with methicillin, while chloramphenicol was associated with a high failure rate."	( Fong, IW; Ranalli, P, 1984)
"Treatment with cloxacillin (500 micrograms) by the intramammary or subcutaneous routes, or equally divided between these two routes, cleared the visceral organs of staphylococci; subcutaneous therapy had a limited and variable effect on numbers of staphylococci in the mammary gland while intramammary and divided treatments significantly reduced the numbers of staphylococci."	( Anderson, JC, 1987)

Role	Description
antibacterial agent	A substance (or active part thereof) that kills or slows the growth of bacteria.
antibacterial drug	A drug used to treat or prevent bacterial infections.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Class	Description
penicillin	Any member of the group of substituted penams containing two methyl substituents at position 2, a carboxylate substituent at position 3 and a carboxamido group at position 6.
semisynthetic derivative	Any organic molecular entity derived from a natural product by partial chemical synthesis.
penicillin allergen	Any penicillin which causes the onset of an allergic reaction.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Beta-lactamase	Escherichia coli	IC50 (µMol)	0.0260	0.0260	0.0290	0.0320	AID394491
Bile salt export pump	Rattus norvegicus (Norway rat)	IC50 (µMol)	376.7000	0.4000	2.7500	8.6000	AID1209456
Solute carrier family 22 member 8	Mus musculus (house mouse)	IC50 (µMol)	30.9000	3.0200	3.0200	3.0200	AID1209730
Bile salt export pump	Homo sapiens (human)	IC50 (µMol)	130.6350	0.1100	7.1903	10.0000	AID1209455; AID1449628
Solute carrier family 15 member 1	Homo sapiens (human)	Ki	2,750.0000	0.1800	3.3933	9.8000	AID238858; AID681115
Beta-lactamase TEM	Escherichia coli	Ki	13.0000	0.0270	1.8234	7.3000	AID43582
Solute carrier family 15 member 2	Homo sapiens (human)	Ki	952.4965	0.7943	4.2210	8.0000	AID612540
Efflux transporter	Salmonella enterica subsp. enterica serovar Newport	IC50 (µMol)	0.0040	0.0040	0.0050	0.0060	AID545146
Beta-lactamase	Klebsiella pneumoniae	IC50 (µMol)	0.0040	0.0040	0.0050	0.0060	AID545147
Solute carrier family 15 member 2	Rattus norvegicus (Norway rat)	Ki	950.0000	3.0000	6.4778	8.5000	AID681114
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Beta-lactamase class B VIM-2	Pseudomonas aeruginosa	Km	250.0000	2.0000	6.6500	9.4000	AID531315
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
fatty acid metabolic process	Bile salt export pump	Homo sapiens (human)
bile acid biosynthetic process	Bile salt export pump	Homo sapiens (human)
xenobiotic metabolic process	Bile salt export pump	Homo sapiens (human)
xenobiotic transmembrane transport	Bile salt export pump	Homo sapiens (human)
response to oxidative stress	Bile salt export pump	Homo sapiens (human)
bile acid metabolic process	Bile salt export pump	Homo sapiens (human)
response to organic cyclic compound	Bile salt export pump	Homo sapiens (human)
bile acid and bile salt transport	Bile salt export pump	Homo sapiens (human)
canalicular bile acid transport	Bile salt export pump	Homo sapiens (human)
protein ubiquitination	Bile salt export pump	Homo sapiens (human)
regulation of fatty acid beta-oxidation	Bile salt export pump	Homo sapiens (human)
carbohydrate transmembrane transport	Bile salt export pump	Homo sapiens (human)
bile acid signaling pathway	Bile salt export pump	Homo sapiens (human)
cholesterol homeostasis	Bile salt export pump	Homo sapiens (human)
response to estrogen	Bile salt export pump	Homo sapiens (human)
response to ethanol	Bile salt export pump	Homo sapiens (human)
xenobiotic export from cell	Bile salt export pump	Homo sapiens (human)
lipid homeostasis	Bile salt export pump	Homo sapiens (human)
phospholipid homeostasis	Bile salt export pump	Homo sapiens (human)
positive regulation of bile acid secretion	Bile salt export pump	Homo sapiens (human)
regulation of bile acid metabolic process	Bile salt export pump	Homo sapiens (human)
transmembrane transport	Bile salt export pump	Homo sapiens (human)
monoatomic ion transport	Solute carrier family 15 member 1	Homo sapiens (human)
protein transport	Solute carrier family 15 member 1	Homo sapiens (human)
peptide transport	Solute carrier family 15 member 1	Homo sapiens (human)
dipeptide import across plasma membrane	Solute carrier family 15 member 1	Homo sapiens (human)
tripeptide import across plasma membrane	Solute carrier family 15 member 1	Homo sapiens (human)
proton transmembrane transport	Solute carrier family 15 member 1	Homo sapiens (human)
monoatomic ion transport	Solute carrier family 15 member 2	Homo sapiens (human)
protein transport	Solute carrier family 15 member 2	Homo sapiens (human)
peptide transport	Solute carrier family 15 member 2	Homo sapiens (human)
peptidoglycan transport	Solute carrier family 15 member 2	Homo sapiens (human)
xenobiotic transport	Solute carrier family 15 member 2	Homo sapiens (human)
dipeptide transport	Solute carrier family 15 member 2	Homo sapiens (human)
renal absorption	Solute carrier family 15 member 2	Homo sapiens (human)
regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	Solute carrier family 15 member 2	Homo sapiens (human)
dipeptide import across plasma membrane	Solute carrier family 15 member 2	Homo sapiens (human)
tripeptide import across plasma membrane	Solute carrier family 15 member 2	Homo sapiens (human)
antibacterial innate immune response	Solute carrier family 15 member 2	Homo sapiens (human)
transport across blood-brain barrier	Solute carrier family 15 member 2	Homo sapiens (human)
proton transmembrane transport	Solute carrier family 15 member 2	Homo sapiens (human)
xenobiotic detoxification by transmembrane export across the plasma membrane	Solute carrier family 15 member 2	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
organic anion transmembrane transporter activity	Solute carrier family 22 member 8	Mus musculus (house mouse)
protein binding	Bile salt export pump	Homo sapiens (human)
ATP binding	Bile salt export pump	Homo sapiens (human)
ABC-type xenobiotic transporter activity	Bile salt export pump	Homo sapiens (human)
bile acid transmembrane transporter activity	Bile salt export pump	Homo sapiens (human)
canalicular bile acid transmembrane transporter activity	Bile salt export pump	Homo sapiens (human)
carbohydrate transmembrane transporter activity	Bile salt export pump	Homo sapiens (human)
ABC-type bile acid transporter activity	Bile salt export pump	Homo sapiens (human)
ATP hydrolysis activity	Bile salt export pump	Homo sapiens (human)
proton-dependent oligopeptide secondary active transmembrane transporter activity	Solute carrier family 15 member 1	Homo sapiens (human)
peptide:proton symporter activity	Solute carrier family 15 member 1	Homo sapiens (human)
tripeptide transmembrane transporter activity	Solute carrier family 15 member 1	Homo sapiens (human)
dipeptide transmembrane transporter activity	Solute carrier family 15 member 1	Homo sapiens (human)
protein binding	Solute carrier family 15 member 2	Homo sapiens (human)
peptide:proton symporter activity	Solute carrier family 15 member 2	Homo sapiens (human)
tripeptide transmembrane transporter activity	Solute carrier family 15 member 2	Homo sapiens (human)
dipeptide transmembrane transporter activity	Solute carrier family 15 member 2	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
basolateral plasma membrane	Solute carrier family 22 member 8	Mus musculus (house mouse)
basolateral plasma membrane	Bile salt export pump	Homo sapiens (human)
Golgi membrane	Bile salt export pump	Homo sapiens (human)
endosome	Bile salt export pump	Homo sapiens (human)
plasma membrane	Bile salt export pump	Homo sapiens (human)
cell surface	Bile salt export pump	Homo sapiens (human)
apical plasma membrane	Bile salt export pump	Homo sapiens (human)
intercellular canaliculus	Bile salt export pump	Homo sapiens (human)
intracellular canaliculus	Bile salt export pump	Homo sapiens (human)
recycling endosome	Bile salt export pump	Homo sapiens (human)
recycling endosome membrane	Bile salt export pump	Homo sapiens (human)
extracellular exosome	Bile salt export pump	Homo sapiens (human)
membrane	Bile salt export pump	Homo sapiens (human)
plasma membrane	Solute carrier family 15 member 1	Homo sapiens (human)
brush border	Solute carrier family 15 member 1	Homo sapiens (human)
membrane	Solute carrier family 15 member 1	Homo sapiens (human)
apical plasma membrane	Solute carrier family 15 member 1	Homo sapiens (human)
plasma membrane	Solute carrier family 15 member 1	Homo sapiens (human)
apical plasma membrane	Solute carrier family 15 member 1	Homo sapiens (human)
phagocytic vesicle membrane	Solute carrier family 15 member 2	Homo sapiens (human)
plasma membrane	Solute carrier family 15 member 2	Homo sapiens (human)
membrane	Solute carrier family 15 member 2	Homo sapiens (human)
apical plasma membrane	Solute carrier family 15 member 2	Homo sapiens (human)
extracellular exosome	Solute carrier family 15 member 2	Homo sapiens (human)
apical plasma membrane	Solute carrier family 15 member 2	Homo sapiens (human)
plasma membrane	Solute carrier family 15 member 2	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (371)

Assay ID	Title	Year	Journal	Article
AID553662	Antimicrobial activity against intracellular hospital acquired methicillin-resistant Staphylococcus aureus ATCC 33591 infected in human Calu3 cells assessed as increase in bacterial count from original inoculum at low compound concentration after 24 hrs a	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID553648	Antimicrobial activity against intracellular hospital acquired methicillin-resistant Staphylococcus aureus ATCC 33591 infected in activated human THP-1 cells assessed as decrease in bacterial count from original inoculum at high compound concentration aft	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID681114	TP_TRANSPORTER: inhibition of Gly-Sar uptake (pH6.0) in SKPT cells	2005	European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, Jan, Volume: 59, Issue:1	Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1.
AID553701	Antimicrobial activity against hospital acquired methicillin-resistant Staphylococcus aureus ATCC 33591 by broth microdilution method at pH 7.4	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID558538	Antibacterial activity against bla-positive and beta-lactamase-weakly positive Campylobacter coli isolate P1627 by NCCLS agar doubling dilution method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni.
AID1209730	Inhibition of mouse OAT3 expressed in CHO cells assessed as inhibition of fluorescein uptake over 20 mins	2013	Drug metabolism and disposition: the biological fate of chemicals, Apr, Volume: 41, Issue:4	Organic anion transporter 3 interacts selectively with lipophilic β-lactam antibiotics.
AID553884	Antimicrobial activity against hospital acquired methicillin-resistant and vancomycin-intermediate Staphylococcus aureus VRS2 obtained from wound, skin and soft tissue infection of patient infected in human THP-1 cells assessed as decrease in bacterial gr	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID1079931	Moderate liver toxicity, defined via clinical-chemistry results: ALT or AST serum activity 6 times the normal upper limit (N) or alkaline phosphatase serum activity of 1.7 N. Value is number of references indexed. [column 'BIOL' in source]
AID554987	Antibacterial activity against Acinetobacter genomosp. 3 isolate 52 by Etest method	2009	Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3	Genetic variability among ampC genes from acinetobacter genomic species 3.
AID531313	Activity of Pseudomonas aeruginosa beta-lactamase VIM-7 by spectrophotometry	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Kinetic characterization of VIM-7, a divergent member of the VIM metallo-beta-lactamase family.
AID1533863	Antibacterial activity against multidrug-resistant Staphylococcus aureus isolate 757 by broth microdilution assay	2019	European journal of medicinal chemistry, Feb-01, Volume: 163	Boosting the efficacy of anti-MRSA β-lactam antibiotics via an easily accessible, non-cytotoxic and orally bioavailable FtsZ inhibitor.
AID325449	Antibacterial activity against Staphylococcus aureus ATCC 3556 after 14 to 16 hrs by broth dilution method	2007	Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6	Polyamine effects on antibiotic susceptibility in bacteria.
AID1533862	Antibacterial activity against multidrug-resistant Staphylococcus aureus isolate 3267 by broth microdilution assay	2019	European journal of medicinal chemistry, Feb-01, Volume: 163	Boosting the efficacy of anti-MRSA β-lactam antibiotics via an easily accessible, non-cytotoxic and orally bioavailable FtsZ inhibitor.
AID553731	Antimicrobial activity against hospital acquired methicillin-resistant Staphylococcus aureus HMC546 infected in human THP-1 cells assessed as increase in bacterial count from original inoculum at low compound concentration after 24 hrs at pH 5.5	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID1533871	Antibacterial activity against multidrug-resistant Staphylococcus aureus isolate 3580 by broth microdilution assay	2019	European journal of medicinal chemistry, Feb-01, Volume: 163	Boosting the efficacy of anti-MRSA β-lactam antibiotics via an easily accessible, non-cytotoxic and orally bioavailable FtsZ inhibitor.
AID553667	Bacteriostatic activity against intracellular beta-lactamase negative methicillin-susceptible Staphylococcus aureus ATCC 25923 infected in human Calu3 cells assessed as decrease in bacterial growth after 24 hrs at pH 7.4	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID323859	Antimicrobial activity against methicillin-susceptible Staphylococcus aureus ATCC 25923 after phagocytosis by human THP1 macrophages assessed as reduction in bacterial count after 24 hrs	2007	Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5	Role of acidic pH in the susceptibility of intraphagocytic methicillin-resistant Staphylococcus aureus strains to meropenem and cloxacillin.
AID478499	Antifungal activity against Fusarium solani at 2 mg/ml after 7 days by agar diffusion method	2010	European journal of medicinal chemistry, May, Volume: 45, Issue:5	Synthesis and antimicrobial of new anthraquinone derivatives incorporating pyrazole moiety.
AID444055	Fraction absorbed in human	2010	Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3	Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
AID1079942	Steatosis, proven histopathologically. Value is number of references indexed. [column 'STEAT' in source]
AID278557	Antimicrobial activity against 90 mins oxgall-stressed Bifidobacterium thermophilum ATCC 25866 after 18 hrs	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID311524	Oral bioavailability in human	2007	Bioorganic & medicinal chemistry, Dec-15, Volume: 15, Issue:24	Hologram QSAR model for the prediction of human oral bioavailability.
AID553656	Antimicrobial activity against intracellular hospital acquired methicillin-resistant Staphylococcus aureus ATCC 33591 infected in human keratinocytes assessed as decrease in bacterial count from original inoculum at high compound concentration after 24 hr	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID553671	Antimicrobial activity against beta-lactamase negative methicillin-susceptible Staphylococcus aureus ATCC 25923 infected in human THP-1 cells assessed as increase in bacterial count from original inoculum at low compound concentration after 24 hrs at pH 7	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID444056	Fraction escaping gut-wall elimination in human	2010	Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3	Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
AID555214	Antibacterial activity against Acinetobacter genomosp. 3 isolate 243 by Etest method	2009	Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3	Genetic variability among ampC genes from acinetobacter genomic species 3.
AID660263	Ratio of MIC for wild type Salmonella typhimurium SH5014 to MIC for Salmonella typhimurium SH7616 harboring missense mutation in acrA/acrB gene by two-fold serial dilution method	2012	European journal of medicinal chemistry, Jun, Volume: 52	Computational analysis of structure-based interactions and ligand properties can predict efflux effects on antibiotics.
AID558319	Antibacterial activity against Campylobacter coli by NCCLS agar doubling dilution method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni.
AID1079947	Comments (NB not yet translated). [column 'COMMENTAIRES' in source]
AID409960	Inhibition of bovine brain MAOB	2008	Journal of medicinal chemistry, Nov-13, Volume: 51, Issue:21	Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
AID1079946	Presence of at least one case with successful reintroduction. [column 'REINT' in source]
AID278560	Antimicrobial activity against 90 mins hydrogen peroxide-stressed Bifidobacterium bifidum BB12 after 18 hrs	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID323865	Reversal bacterial susceptibility against methicillin-resistant Staphylococcus aureus ATCC 33591 after phagocytosis by human THP1 macrophages assessed as bacterial count in presence of 10 mM ammonium chloride after 24 hrs	2007	Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5	Role of acidic pH in the susceptibility of intraphagocytic methicillin-resistant Staphylococcus aureus strains to meropenem and cloxacillin.
AID553714	Antimicrobial activity against hospital acquired methicillin-resistant Staphylococcus aureus ATCC 33591 by broth microdilution method at pH 5.5	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID555209	Antibacterial activity against Acinetobacter genomosp. 3 isolate 90 by Etest method	2009	Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3	Genetic variability among ampC genes from acinetobacter genomic species 3.
AID553675	Antimicrobial activity against beta-lactamase negative methicillin-susceptible Staphylococcus aureus ATCC 25923 infected in human THP-1 cells assessed as decrease in bacterial growth after 24 hrs at pH 7.4	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID553660	Bacteriostatic activity against intracellular hospital acquired methicillin-resistant Staphylococcus aureus ATCC 33591 infected in human keratinocytes assessed as decrease in bacterial growth after 24 hrs at pH 7.4	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID553863	Antimicrobial activity against hospital acquired methicillin-resistant Staphylococcus aureus N4120032 obtained from wound infection opf patient infected in human THP-1 cells assessed as decrease in bacterial count from original inoculum at high compound c	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID553886	Bacteriostatic activity against beta-lactamase negative methicillin-susceptible Staphylococcus aureus ATCC 25923 infected in human THP-1 cells assessed as decrease in bacterial growth after 24 hrs at pH 5.5	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID278565	Antimicrobial activity against 90 mins hydrogen peroxide-stressed Bifidobacterium longum R0175 after 18 hrs	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID553872	Antimicrobial activity against animal acquired methicillin-resistant Staphylococcus aureus N7112046 infected in human THP-1 cells assessed as decrease in bacterial count from original inoculum at high compound concentration after 24 hrs at pH 5.5	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID1209735	Inhibition of mouse OAT3 expressed in CHO cells assessed as inhibition of fluorescein uptake at 500 uM over 20 mins relative to untreated-control	2013	Drug metabolism and disposition: the biological fate of chemicals, Apr, Volume: 41, Issue:4	Organic anion transporter 3 interacts selectively with lipophilic β-lactam antibiotics.
AID1533855	Antibacterial activity against multidrug-resistant Staphylococcus aureus isolate 3589 by broth microdilution assay	2019	European journal of medicinal chemistry, Feb-01, Volume: 163	Boosting the efficacy of anti-MRSA β-lactam antibiotics via an easily accessible, non-cytotoxic and orally bioavailable FtsZ inhibitor.
AID545148	Inhibition of CMY-2 by UV spectrophotometer in presence of 100 uM of cephalothin	2009	Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3	CMY-31 and CMY-36 cephalosporinases encoded by ColE1-like plasmids.
AID553739	Antimicrobial activity against beta-lactamase negative methicillin-susceptible Staphylococcus aureus ATCC 25923 infected in human THP-1 cells assessed as decrease in bacterial count from original inoculum at high compound concentration after 24 hrs at pH	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID531315	Activity of Pseudomonas aeruginosa beta-lactamase VIM-2 by spectrophotometry	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Kinetic characterization of VIM-7, a divergent member of the VIM metallo-beta-lactamase family.
AID369979	Antibacterial activity against methicillin-sensitive Staphylococcus aureus infected rabbit arthritis model assessed as change in bacterial load per gram of synovial fluid at 50 mg/kg, im administered thrice a day after 7 days by broth microdilution techni	2007	Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9	In vivo efficacy of moxifloxacin compared with cloxacillin and vancomycin in a Staphylococcus aureus rabbit arthritis experimental model.
AID1321392	Antibacterial activity against Staphylococcus aureus ATCC 29213 by broth microdilution method	2016	Journal of medicinal chemistry, 10-13, Volume: 59, Issue:19	The Rational Design, Synthesis, and Antimicrobial Properties of Thiophene Derivatives That Inhibit Bacterial Histidine Kinases.
AID1533850	Antibacterial activity against multidrug-resistant Staphylococcus aureus isolate 254 by broth microdilution assay	2019	European journal of medicinal chemistry, Feb-01, Volume: 163	Boosting the efficacy of anti-MRSA β-lactam antibiotics via an easily accessible, non-cytotoxic and orally bioavailable FtsZ inhibitor.
AID524261	Antibacterial activity against Escherichia coli NKE154 harboring vector expressing acrB deletion mutant	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Effect of NlpE overproduction on multidrug resistance in Escherichia coli.
AID553883	Antimicrobial activity against hospital acquired methicillin-resistant and vancomycin-intermediate Staphylococcus aureus NRS126 obtained from bloodstream infection of patient infected in human THP-1 cells assessed as decrease in bacterial growth after 24	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID444057	Fraction escaping hepatic elimination in human	2010	Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3	Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
AID524262	Antibacterial activity against Escherichia coli NKE155 harboring deletion mutation in acrB protein and plasmid expressing nlpE gene	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Effect of NlpE overproduction on multidrug resistance in Escherichia coli.
AID553871	Antimicrobial activity against hospital acquired methicillin-resistant and vancomycin-intermediate Staphylococcus aureus VRS2 obtained from wound, skin and soft tissue infection of patient infected in human THP-1 cells assessed as decrease in bacterial co	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID278558	Antimicrobial activity against 90 mins hydrogen peroxide-stressed Bifidobacterium animalis ATCC 27536 after 18 hrs	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID1209456	Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake	2012	Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 40, Issue:1	In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
AID553706	Antimicrobial activity against Panton-valentine leukocidin positive community acquired methicillin-resistant Staphylococcus aureus N4090440 obtained from wound infection of patient by broth microdilution method at pH 7.4	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID394491	Inhibition of Escherichia coli beta-lactamase ACC4	2007	Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10	Plasmid-encoded ACC-4, an extended-spectrum cephalosporinase variant from Escherichia coli.
AID531317	Activity of Escherichia coli beta-lactamase VIM-1 by spectrophotometry	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Kinetic characterization of VIM-7, a divergent member of the VIM metallo-beta-lactamase family.
AID553650	Antimicrobial activity against intracellular hospital acquired methicillin-resistant Staphylococcus aureus ATCC 33591 activated infected in human THP-1 cells assessed as decrease in bacterial growth after 24 hrs at pH 7.4	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID1533864	Antibacterial activity against multidrug-resistant Staphylococcus aureus isolate 1749 by broth microdilution assay	2019	European journal of medicinal chemistry, Feb-01, Volume: 163	Boosting the efficacy of anti-MRSA β-lactam antibiotics via an easily accessible, non-cytotoxic and orally bioavailable FtsZ inhibitor.
AID553674	Antimicrobial activity against hospital acquired methicillin-resistant Staphylococcus aureus ATCC 33591 infected in human THP-1 cells assessed as decrease in bacterial count from original inoculum at high compound concentration after 24 hrs at pH 7.4	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID558780	Antibacterial activity against acrEF-deficient Salmonella enterica NKS176 by CLSI method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	H-NS modulates multidrug resistance of Salmonella enterica serovar Typhimurium by repressing multidrug efflux genes acrEF.
AID524394	Antibacterial activity against Escherichia coli NKE1355 harboring deletion mutation in acrB protein and plasmid expressing BAD gene in presence of increasing concentration of arabinose	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Effect of NlpE overproduction on multidrug resistance in Escherichia coli.
AID555213	Antibacterial activity against Acinetobacter genomosp. 3 isolate 195 by Etest method	2009	Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3	Genetic variability among ampC genes from acinetobacter genomic species 3.
AID278553	Antimicrobial activity against 90 mins oxgall-stressed Bifidobacterium longum ATCC 15708 after 18 hrs	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID1079941	Liver damage due to vascular disease: peliosis hepatitis, hepatic veno-occlusive disease, Budd-Chiari syndrome. Value is number of references indexed. [column 'VASC' in source]
AID1474166	Liver toxicity in human assessed as induction of drug-induced liver injury by measuring severity class index	2016	Drug discovery today, Apr, Volume: 21, Issue:4	DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
AID278566	Antimicrobial activity against 90 mins hydrogen peroxide-stressed Bifidobacterium longum P/N 601377 after 18 hrs	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID553711	Antimicrobial activity against hospital acquired methicillin-resistant and vancomycin-intermediate Staphylococcus aureus VRS2 obtained from patient with wound, skin and soft tissue infection by broth microdilution method at pH 7.4	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID553702	Antimicrobial activity against constitutive beta-lactamase negative methicillin-resistant Staphylococcus aureus COL NRS100 by broth microdilution method at pH 7.4	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID1533869	Antibacterial activity against multidrug-resistant Staphylococcus aureus isolate 2224 by broth microdilution assay	2019	European journal of medicinal chemistry, Feb-01, Volume: 163	Boosting the efficacy of anti-MRSA β-lactam antibiotics via an easily accessible, non-cytotoxic and orally bioavailable FtsZ inhibitor.
AID325444	Antibacterial activity against Escherichia coli K12 after 14 to 16 hrs by broth dilution method	2007	Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6	Polyamine effects on antibiotic susceptibility in bacteria.
AID467875	Antibacterial activity against methicillin-resistant Staphylococcus aureus by NCCLS method	2009	Journal of natural products, Dec, Volume: 72, Issue:12	Methicillin-resistant Staphylococcus aureus (MRSA)-active metabolites from Platanus occidentalis (American Sycamore).
AID558779	Antibacterial activity against tolC-deficient Salmonella enterica NKS419 harboring hns gene by CLSI method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	H-NS modulates multidrug resistance of Salmonella enterica serovar Typhimurium by repressing multidrug efflux genes acrEF.
AID524263	Antibacterial activity against Escherichia coli NKE127 harboring deletion mutation in acrB and cpxAR protein	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Effect of NlpE overproduction on multidrug resistance in Escherichia coli.
AID278532	Antimicrobial activity against Bifidobacterium thermophilum ATCC 25866	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID478496	Antibacterial activity against Staphylococcus epidermidis at 2 mg/ml after 24 hrs by agar diffusion method	2010	European journal of medicinal chemistry, May, Volume: 45, Issue:5	Synthesis and antimicrobial of new anthraquinone derivatives incorporating pyrazole moiety.
AID553719	Antimicrobial activity against Panton-valentine leukocidin positive community acquired methicillin-resistant Staphylococcus aureus N4090440 obtained from wound infection of patient by broth microdilution method at pH 5.5	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID1079944	Benign tumor, proven histopathologically. Value is number of references indexed. [column 'T.BEN' in source]
AID278523	Antimicrobial activity against Bifidobacterium bifidum ATCC 15696	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID524393	Antibacterial activity against Escherichia coli NKE1359 harboring deletion mutation in acrB protein and plasmid expressing BADnlpE gene in presence of increasing concentration of arabinose	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Effect of NlpE overproduction on multidrug resistance in Escherichia coli.
AID553730	Antimicrobial activity against hospital acquired methicillin-resistant Staphylococcus aureus N4120210 obtained from urinary tract infection of patient infected in human THP-1 cells assessed as increase in bacterial count from original inoculum at low comp	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID1079937	Severe hepatitis, defined as possibly life-threatening liver failure or through clinical observations. Value is number of references indexed. [column 'MASS' in source]
AID553736	Antimicrobial activity against hospital acquired methicillin-resistant and vancomycin-intermediate Staphylococcus aureus NRS126 obtained from bloodstream infection of patient infected in human THP-1 cells assessed as increase in bacterial count from origi	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID278567	Antimicrobial activity against 90 mins hydrogen peroxide-stressed Bifidobacterium thermophilum ATCC 25866 after 18 hrs	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID553657	Antimicrobial activity against intracellular beta-lactamase negative methicillin-susceptible Staphylococcus aureus ATCC 25923 infected in human keratinocytes assessed as decrease in bacterial growth after 24 hrs at pH 7.4	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID369967	Antibacterial activity against methicillin-sensitive Staphylococcus aureus by broth microdilution technique	2007	Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9	In vivo efficacy of moxifloxacin compared with cloxacillin and vancomycin in a Staphylococcus aureus rabbit arthritis experimental model.
AID553881	Antimicrobial activity against Panton-valentine leukocidin positive community acquired methicillin-resistant Staphylococcus aureus NRS192 obtained from patient with pneumonia and septic arthritis infected in human THP-1 cells assessed as decrease in bacte	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID558776	Antibacterial activity against acrB-deficient Salmonella enterica NKS175 by CLSI method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	H-NS modulates multidrug resistance of Salmonella enterica serovar Typhimurium by repressing multidrug efflux genes acrEF.
AID553676	Antimicrobial activity against hospital acquired methicillin-resistant Staphylococcus aureus ATCC 33591 infected in human THP-1 cells assessed as decrease in bacterial growth after 24 hrs at pH 7.4	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID558330	Antibacterial activity against bla gene-positive and nitrocefin reaction-positive beta-lactamase harboring Campylobacter jejuni isolate P316 by NCCLS agar doubling dilution method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni.
AID560705	Inhibition of Escherichia coli MC4100 Beta-Lactamase CMY-30 using cephalothin as reporter substrate	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Extended-spectrum properties of CMY-30, a Val211Gly mutant of CMY-2 cephalosporinase.
AID553868	Antimicrobial activity against Panton-valentine leukocidin positive community acquired methicillin-resistant Staphylococcus aureus NRS192 obtained from patient with pneumonia and septic arthritis infected in human THP-1 cells assessed as decrease in bacte	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID1706286	Protein binding in plasma (unknown origin)	2020	European journal of medicinal chemistry, Dec-15, Volume: 208	β-lactam antibiotics: An overview from a medicinal chemistry perspective.
AID558318	Antibacterial activity against Campylobacter jejuni by NCCLS agar doubling dilution method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni.
AID524389	Antibacterial activity against Escherichia coli NKE1367 harboring deletion mutation in acrB, mdtABC protein and plasmid expressing nlpE gene	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Effect of NlpE overproduction on multidrug resistance in Escherichia coli.
AID323867	Antibacterial activity against methicillin-resistant Staphylococcus aureus 459 at pH 7.4	2007	Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5	Role of acidic pH in the susceptibility of intraphagocytic methicillin-resistant Staphylococcus aureus strains to meropenem and cloxacillin.
AID278531	Antimicrobial activity against Bifidobacterium pseudolongum ATCC 25562	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID467876	Antibacterial activity against Staphylococcus aureus by NCCLS method	2009	Journal of natural products, Dec, Volume: 72, Issue:12	Methicillin-resistant Staphylococcus aureus (MRSA)-active metabolites from Platanus occidentalis (American Sycamore).
AID1079933	Acute liver toxicity defined via clinical observations and clear clinical-chemistry results: serum ALT or AST activity > 6 N or serum alkaline phosphatases activity > 1.7 N. This category includes cytolytic, choleostatic and mixed liver toxicity. Value is
AID1079936	Choleostatic liver toxicity, either proven histopathologically or where the ratio of maximal ALT or AST activity above normal to that of Alkaline Phosphatase is < 2 (see ACUTE). Value is number of references indexed. [column 'CHOLE' in source]
AID553737	Antimicrobial activity against hospital acquired methicillin-resistant and vancomycin-intermediate Staphylococcus aureus VRS2 obtained from wound, skin and soft tissue infection of patient infected in human THP-1 cells assessed as increase in bacterial co	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID553866	Antimicrobial activity against Panton-valentine leukocidin positive community acquired methicillin-resistant Staphylococcus aureus N4090440 obtained from wound infection of patient infected in human THP-1 cells assessed as decrease in bacterial count from	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID278525	Antimicrobial activity against Bifidobacterium breve ATCC 15700	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID545147	Inhibition of Klebsiella pneumoniae HP205 cephalosporinase CMY-36 by UV spectrophotometer in presence of 100 uM of cephalothin	2009	Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3	CMY-31 and CMY-36 cephalosporinases encoded by ColE1-like plasmids.
AID553670	Chemical stability of the compound assessed as compound remaining after 24 hrs PBS buffer by HPLC analysis at pH 5.5	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID278521	Antimicrobial activity against Bifidobacterium animalis ATCC 27536	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID554990	Antibacterial activity against Acinetobacter genomosp. 3 isolate 65 by Etest method	2009	Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3	Genetic variability among ampC genes from acinetobacter genomic species 3.
AID555211	Antibacterial activity against Acinetobacter genomosp. 3 isolate 109 by Etest method	2009	Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3	Genetic variability among ampC genes from acinetobacter genomic species 3.
AID553874	Antimicrobial activity against hospital acquired methicillin-resistant Staphylococcus aureus ATCC 33591 infected in human THP-1 cells assessed as decrease in bacterial growth after 24 hrs at pH 5.5	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID545146	Inhibition of Salmonella enterica serotype Newport AM17274 cephalosporinase CMY-31 by UV spectrophotometer in presence of 100 uM of cephalothin	2009	Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3	CMY-31 and CMY-36 cephalosporinases encoded by ColE1-like plasmids.
AID558537	Antibacterial activity against bla gene-positive and nitrocefin reaction-positive beta-lactamase harboring Campylobacter coli isolate P321 by NCCLS agar doubling dilution method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni.
AID553668	Bacteriostatic activity against intracellular hospital acquired methicillin-resistant Staphylococcus aureus ATCC 33591 infected in human Calu3 cells assessed as decrease in bacterial growth after 24 hrs at pH 7.4	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID524391	Antibacterial activity against Escherichia coli NKE1368 harboring deletion mutation in acrB, acrD and vector expressing mdtABC gene	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Effect of NlpE overproduction on multidrug resistance in Escherichia coli.
AID278529	Antimicrobial activity against Bifidobacterium longum R0175	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID553704	Antimicrobial activity against hospital acquired methicillin-resistant Staphylococcus aureus N4120210 obtained from urinary tract infection patient by broth microdilution method at pH 7.4	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID278554	Antimicrobial activity against 90 mins oxgall-stressed Bifidobacterium longum R0175 after 18 hrs	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID558332	Antibacterial activity against Campylobacter jejuni isolate P338 harboring blaOXA-61::cat gene by NCCLS agar doubling dilution method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni.
AID524384	Antibacterial activity against Escherichia coli NKE126 harboring deletion mutation in acrB and acrD protein	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Effect of NlpE overproduction on multidrug resistance in Escherichia coli.
AID523274	Activity at Escherichia coli isolate 7181 beta-lactamase OXA-7 measured per mg of protein	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Kinetic parameters of efflux of penicillins by the multidrug efflux transporter AcrAB-TolC of Escherichia coli.
AID278540	Antimicrobial activity against 60 min 1 M HCl-stressed Bifidobacterium longum ATCC 15707 after 18 hrs	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID553877	Antimicrobial activity against hospital acquired methicillin-resistant Staphylococcus aureus N4120210 obtained from urinary tract infection of patient infected in human THP-1 cells assessed as decrease in bacterial growth after 24 hrs at pH 5.5	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID553703	Antimicrobial activity against hospital acquired methicillin-resistant Staphylococcus aureus N4120032 obtained from wound infection of patient by broth microdilution method at pH 7.4	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID553666	Antimicrobial activity against intracellular hospital acquired methicillin-resistant Staphylococcus aureus ATCC 33591 infected in human Calu3 cells assessed as decrease in bacterial growth after 24 hrs at pH 7.4	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID325443	Antibacterial activity against Escherichia coli K10 after 14 to 16 hrs by broth dilution method	2007	Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6	Polyamine effects on antibiotic susceptibility in bacteria.
AID524387	Antibacterial activity against Escherichia coli NKE1365 harboring deletion mutation in acrB and mdtABC protein	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Effect of NlpE overproduction on multidrug resistance in Escherichia coli.
AID524386	Antibacterial activity against Escherichia coli NKE157 harboring deletion mutation in acrB, acrD protein and plasmid expressing nlpE gene	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Effect of NlpE overproduction on multidrug resistance in Escherichia coli.
AID19006	Calculated membrane partition coefficient (Kmemb)	2004	Journal of medicinal chemistry, Mar-25, Volume: 47, Issue:7	Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability.
AID1533868	Antibacterial activity against multidrug-resistant Staphylococcus aureus isolate 1717 by broth microdilution assay	2019	European journal of medicinal chemistry, Feb-01, Volume: 163	Boosting the efficacy of anti-MRSA β-lactam antibiotics via an easily accessible, non-cytotoxic and orally bioavailable FtsZ inhibitor.
AID1209734	Inhibition of mouse OAT1 expressed in CHO cells assessed as inhibition of fluorescein uptake at 500 uM over 20 mins relative to untreated-control	2013	Drug metabolism and disposition: the biological fate of chemicals, Apr, Volume: 41, Issue:4	Organic anion transporter 3 interacts selectively with lipophilic β-lactam antibiotics.
AID369983	Drug level in serum of Staphylococcus aureus infected rabbit arthritis model at 50 mg/kg, im administered thrice a day	2007	Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9	In vivo efficacy of moxifloxacin compared with cloxacillin and vancomycin in a Staphylococcus aureus rabbit arthritis experimental model.
AID553723	Antimicrobial activity against hospital acquired methicillin-resistant and vancomycin-intermediate Staphylococcus aureus NRS126 obtained from patient with bloodstream infection by broth microdilution method at pH 5.5	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID558329	Antibacterial activity against bla gene-positive and nitrocefin reaction-positive beta-lactamase harboring Campylobacter jejuni isolate P305 by NCCLS agar doubling dilution method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni.
AID1533852	Antibacterial activity against multidrug-resistant Staphylococcus aureus isolate 417 by broth microdilution assay	2019	European journal of medicinal chemistry, Feb-01, Volume: 163	Boosting the efficacy of anti-MRSA β-lactam antibiotics via an easily accessible, non-cytotoxic and orally bioavailable FtsZ inhibitor.
AID554984	Antibacterial activity against Acinetobacter genomosp. 3 isolate 14 by Etest method	2009	Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3	Genetic variability among ampC genes from acinetobacter genomic species 3.
AID553678	Bacteriostatic activity against hospital acquired methicillin-resistant Staphylococcus aureus ATCC 33591 infected in human THP-1 cells assessed as decrease in bacterial growth after 24 hrs at pH 7.4	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID553661	Antimicrobial activity against intracellular beta-lactamase negative methicillin-susceptible Staphylococcus aureus ATCC 25923 infected in human Calu3 cells assessed as increase in bacterial count from original inoculum at low compound concentration after	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID1079932	Highest frequency of moderate liver toxicity observed during clinical trials, expressed as a percentage. [column '% BIOL' in source]
AID444054	Oral bioavailability in human	2010	Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3	Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
AID553901	Antimicrobial activity against intracellular beta-lactamase negative methicillin-susceptible Staphylococcus aureus ATCC 25923 infected in activated human THP-1 cells assessed as decrease in bacterial count from original inoculum at high compound concentra	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID558775	Antibacterial activity against Salmonella enterica ATCC 14028 by CLSI method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	H-NS modulates multidrug resistance of Salmonella enterica serovar Typhimurium by repressing multidrug efflux genes acrEF.
AID369982	Cmin in synovial fluid of Staphylococcus aureus infected rabbit arthritis model at 50 mg/kg, im administered thrice a day	2007	Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9	In vivo efficacy of moxifloxacin compared with cloxacillin and vancomycin in a Staphylococcus aureus rabbit arthritis experimental model.
AID553663	Antimicrobial activity against intracellular beta-lactamase negative methicillin-susceptible Staphylococcus aureus ATCC 25923 infected in human Calu3 cells assessed as decrease in bacterial count from original inoculum at high compound concentration after	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID325447	Antibacterial activity against Staphylococcus aureus N315 after 14 to 16 hrs by broth dilution method	2007	Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6	Polyamine effects on antibiotic susceptibility in bacteria.
AID553900	Antimicrobial activity against intracellular hospital acquired methicillin-resistant Staphylococcus aureus ATCC 33591 infected in activated human THP-1 cells assessed as increase in bacterial count from original inoculum at low compound concentration afte	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID523273	Antimicrobial activity against Escherichia coli HN1157/pHSG576oxa7	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Kinetic parameters of efflux of penicillins by the multidrug efflux transporter AcrAB-TolC of Escherichia coli.
AID1474167	Liver toxicity in human assessed as induction of drug-induced liver injury by measuring verified drug-induced liver injury concern status	2016	Drug discovery today, Apr, Volume: 21, Issue:4	DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
AID553722	Antimicrobial activity against hospital acquired methicillin-resistant and vancomycin-intermediate Staphylococcus aureus NRS18 obtained from patient with wound, skin and soft tissue infection by broth microdilution method at pH 5.5	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID553729	Antimicrobial activity against hospital acquired methicillin-resistant Staphylococcus aureus N4120032 obtained from wound infection of patient infected in human THP-1 cells assessed as increase in bacterial count from original inoculum at low compound con	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID1209457	Unbound Cmax in human plasma	2012	Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 40, Issue:1	In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
AID558325	Antibacterial activity against bla gene-negative and nitrocefin reaction-negative beta-lactamase harboring Campylobacter jejuni isolate P850 by NCCLS agar doubling dilution method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni.
AID278533	Antimicrobial activity against Bifidobacterium breve R0070	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID553659	Bacteriostatic activity against intracellular beta-lactamase negative methicillin-susceptible Staphylococcus aureus ATCC 25923 infected in human keratinocytes assessed as decrease in bacterial growth after 24 hrs at pH 7.4	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID531314	Ratio of Kcat to Km for Pseudomonas aeruginosa beta-lactamase VIM-7 by spectrophotometry	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Kinetic characterization of VIM-7, a divergent member of the VIM metallo-beta-lactamase family.
AID553885	Antimicrobial activity against animal acquired methicillin-resistant Staphylococcus aureus N7112046 infected in human THP-1 cells assessed as decrease in bacterial growth after 24 hrs at pH 5.5	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID558534	Antibacterial activity against bla gene-positive and nitrocefin reaction-negative beta-lactamase harboring Campylobacter jejuni isolate P1699 by NCCLS agar doubling dilution method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni.
AID524382	Antibacterial activity against Escherichia coli NKE160 harboring deletion mutation in acrB protein and vector expressing tolC gene	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Effect of NlpE overproduction on multidrug resistance in Escherichia coli.
AID1079938	Chronic liver disease either proven histopathologically, or through a chonic elevation of serum amino-transferase activity after 6 months. Value is number of references indexed. [column 'CHRON' in source]
AID323860	Antimicrobial activity against methicillin-resistant Staphylococcus aureus ATCC 25923 after phagocytosis by human THP1 macrophages assessed as reduction in bacterial count after 24 hrs	2007	Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5	Role of acidic pH in the susceptibility of intraphagocytic methicillin-resistant Staphylococcus aureus strains to meropenem and cloxacillin.
AID323864	Antimicrobial activity against methicillin-susceptible Staphylococcus aureus ATCC 25923 after phagocytosis by human THP1 macrophages assessed as reduction in bacterial count at pH 5.5 after 24 hrs	2007	Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5	Role of acidic pH in the susceptibility of intraphagocytic methicillin-resistant Staphylococcus aureus strains to meropenem and cloxacillin.
AID553899	Antimicrobial activity against intracellular beta-lactamase negative methicillin-susceptible Staphylococcus aureus ATCC 25923 infected in activated human THP-1 cells assessed as increase in bacterial count from original inoculum at low compound concentrat	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID554991	Antibacterial activity against Acinetobacter genomosp. 3 isolate 67 by Etest method	2009	Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3	Genetic variability among ampC genes from acinetobacter genomic species 3.
AID278548	Antimicrobial activity against 90 mins oxgall-stressed Bifidobacterium bifidum BB12 after 18 hrs	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID553882	Antimicrobial activity against hospital acquired methicillin-resistant and vancomycin-intermediate Staphylococcus aureus NRS18 obtained from wound, skin and soft tissue infection of patient infected in human THP-1 cells assessed as decrease in bacterial g	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID323862	Antimicrobial activity against methicillin-resistant Staphylococcus aureus ATCC 25923 after phagocytosis by human THP1 macrophages assessed as reduction in bacterial count at pH 7.4 after 24 hrs	2007	Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5	Role of acidic pH in the susceptibility of intraphagocytic methicillin-resistant Staphylococcus aureus strains to meropenem and cloxacillin.
AID278555	Antimicrobial activity against 90 mins oxgall-stressed Bifidobacterium longum P/N 601377 after 18 hrs	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID604744	Displacement of radiolabeled dansylsarcosine from fatty acid containing human serum albumin site 2 in phosphate buffer at pH 7.4 at 12 uM by fluorescence spectroscopy	2010	Bioorganic & medicinal chemistry, Nov-01, Volume: 18, Issue:21	A combined spectroscopic and crystallographic approach to probing drug-human serum albumin interactions.
AID558777	Antibacterial activity against acrB-deficient Salmonella enterica NKS291 harboring hns gene by CLSI method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	H-NS modulates multidrug resistance of Salmonella enterica serovar Typhimurium by repressing multidrug efflux genes acrEF.
AID554985	Antibacterial activity against Acinetobacter genomosp. 3 isolate 20 by Etest method	2009	Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3	Genetic variability among ampC genes from acinetobacter genomic species 3.
AID1533876	Antibacterial activity against multidrug-resistant Staphylococcus aureus isolate 1449 by broth microdilution assay	2019	European journal of medicinal chemistry, Feb-01, Volume: 163	Boosting the efficacy of anti-MRSA β-lactam antibiotics via an easily accessible, non-cytotoxic and orally bioavailable FtsZ inhibitor.
AID1079943	Malignant tumor, proven histopathologically. Value is number of references indexed. [column 'T.MAL' in source]
AID278522	Antimicrobial activity against Bifidobacterium bifidum R0071	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID553665	Antimicrobial activity against intracellular beta-lactamase negative methicillin-susceptible Staphylococcus aureus ATCC 25923 infected in human Calu3 cells assessed as decrease in bacterial growth after 24 hrs at pH 7.4	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID554989	Antibacterial activity against Acinetobacter genomosp. 3 isolate 60 by Etest method	2009	Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3	Genetic variability among ampC genes from acinetobacter genomic species 3.
AID1309043	Antibacterial activity against methicillin-sensitive Staphylococcus aureus isolate SDS15016 after 24 hrs by broth microdilution method	2016	Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15	Synthesis of riccardin D derivatives as potent antimicrobial agents.
AID681783	TP_TRANSPORTER: inhibition of PAH uptake (PAH: 2 uM, Cloxacillin: 2000 uM) in Xenopus laevis oocytes	1999	The Journal of pharmacology and experimental therapeutics, Aug, Volume: 290, Issue:2	The interaction and transport of beta-lactam antibiotics with the cloned rat renal organic anion transporter 1.
AID323863	Antimicrobial activity against methicillin-susceptible Staphylococcus aureus ATCC 25923 after phagocytosis by human THP1 macrophages assessed as reduction in bacterial count at pH 5.5 after 24 hrs	2007	Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5	Role of acidic pH in the susceptibility of intraphagocytic methicillin-resistant Staphylococcus aureus strains to meropenem and cloxacillin.
AID1533849	Antibacterial activity against multidrug-resistant Staphylococcus aureus isolate 2490 by broth microdilution assay	2019	European journal of medicinal chemistry, Feb-01, Volume: 163	Boosting the efficacy of anti-MRSA β-lactam antibiotics via an easily accessible, non-cytotoxic and orally bioavailable FtsZ inhibitor.
AID325448	Antibacterial activity against Staphylococcus aureus Mu50 after 14 to 16 hrs by broth dilution method	2007	Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6	Polyamine effects on antibiotic susceptibility in bacteria.
AID554986	Antibacterial activity against Acinetobacter genomosp. 3 isolate 21 by Etest method	2009	Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3	Genetic variability among ampC genes from acinetobacter genomic species 3.
AID1079945	Animal toxicity known. [column 'TOXIC' in source]
AID278535	Antimicrobial activity against 60 min 1 M HCl-stressed Bifidobacterium bifidum R0071 after 18 hrs	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID278524	Antimicrobial activity against Bifidobacterium bifidum BB12	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID553870	Antimicrobial activity against hospital acquired methicillin-resistant and vancomycin-intermediate Staphylococcus aureus NRS126 obtained from bloodstream infection of patient infected in human THP-1 cells assessed as decrease in bacterial count from origi	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID553879	Antimicrobial activity against Panton-valentine leukocidin positive community acquired methicillin-resistant Staphylococcus aureus N4090440 obtained from wound infection of patient infected in human THP-1 cells assessed as decrease in bacterial growth aft	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID478498	Antifungal activity against Alternaria solani at 2 mg/ml after 7 days by agar diffusion method	2010	European journal of medicinal chemistry, May, Volume: 45, Issue:5	Synthesis and antimicrobial of new anthraquinone derivatives incorporating pyrazole moiety.
AID660265	Antimicrobial activity against wild type Escherichia coli expressing AcrAB-TolC efflux pump	2012	European journal of medicinal chemistry, Jun, Volume: 52	Computational analysis of structure-based interactions and ligand properties can predict efflux effects on antibiotics.
AID1209731	Drug uptake by mouse OAT3 expressed in CHO cells at 100 uM after 25 mins by HPLC/UV detection method	2013	Drug metabolism and disposition: the biological fate of chemicals, Apr, Volume: 41, Issue:4	Organic anion transporter 3 interacts selectively with lipophilic β-lactam antibiotics.
AID524264	Antibacterial activity against Escherichia coli NKE158 harboring deletion mutation in acrB protein and vector expressing cpxAR gene	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Effect of NlpE overproduction on multidrug resistance in Escherichia coli.
AID558326	Antibacterial activity against bla gene-negative and nitrocefin reaction-negative beta-lactamase harboring Campylobacter jejuni isolate P1962 by NCCLS agar doubling dilution method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni.
AID604741	Displacement of radiolabeled warfarin from fatty acid-free human serum albumin site 1 in phosphate buffer at pH 7.4 at 12 uM by fluorescence spectroscopy	2010	Bioorganic & medicinal chemistry, Nov-01, Volume: 18, Issue:21	A combined spectroscopic and crystallographic approach to probing drug-human serum albumin interactions.
AID43582	Inhibition constant (Ki) for TEM-1 beta-lactamase	1988	Journal of medicinal chemistry, Feb, Volume: 31, Issue:2	N-aryl 3-halogenated azetidin-2-ones and benzocarbacephems, inhibitors of beta-lactamases.
AID238858	Binding affinity against membrane transport protein PEPT1 in human Caco-2 cells	2005	Journal of medicinal chemistry, Jun-30, Volume: 48, Issue:13	Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1.
AID553721	Antimicrobial activity against Panton-valentine leukocidin positive community acquired methicillin-resistant Staphylococcus aureus NRS192 obtained from patient with pneumonia and septic arthritis by broth microdilution method at pH 5.5	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID558781	Antibacterial activity against acrB-deficient Salmonella enterica NKS422 harboring acrEF gene by CLSI method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	H-NS modulates multidrug resistance of Salmonella enterica serovar Typhimurium by repressing multidrug efflux genes acrEF.
AID553726	Antimicrobial activity against beta-lactamase negative methicillin-susceptible Staphylococcus aureus ATCC 25923 infected in human THP-1 cells assessed as increase in bacterial count from original inoculum at low compound concentration after 24 hrs at pH 5	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID660261	Ratio of MIC for wild type Escherichia coli JC7623 to MIC for acrAB-deficient Escherichia coli JZM120	2012	European journal of medicinal chemistry, Jun, Volume: 52	Computational analysis of structure-based interactions and ligand properties can predict efflux effects on antibiotics.
AID278539	Antimicrobial activity against 60 min 1 M HCl-stressed Bifidobacterium infantis ATCC 15697 after 18 hrs	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID558533	Antibacterial activity against bla gene-positive and nitrocefin reaction-negative beta-lactamase harboring Campylobacter jejuni isolate P1698 by NCCLS agar doubling dilution method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni.
AID553895	Bacteriostatic activity against hospital acquired methicillin-resistant and vancomycin-intermediate Staphylococcus aureus NRS18 infected in human THP-1 cells assessed as decrease in bacterial growth after 24 hrs at pH 5.5	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID278527	Antimicrobial activity against Bifidobacterium longum ATCC 15707	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID553655	Antimicrobial activity against intracellular beta-lactamase negative methicillin-susceptible Staphylococcus aureus ATCC 25923 infected in human keratinocytes assessed as decrease in bacterial count from original inoculum at high compound concentration aft	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID553705	Antimicrobial activity against hospital acquired methicillin-resistant Staphylococcus aureus HMC546 by broth microdilution method at pH 7.4	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID524265	Antibacterial activity against Escherichia coli NKE159 harboring deletion mutation in acrB, cpxAR protein and plasmid expressing nlpE gene	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Effect of NlpE overproduction on multidrug resistance in Escherichia coli.
AID323861	Antimicrobial activity against methicillin-susceptible Staphylococcus aureus ATCC 25923 after phagocytosis by human THP1 macrophages assessed as reduction in bacterial count at pH 7.4 after 24 hrs	2007	Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5	Role of acidic pH in the susceptibility of intraphagocytic methicillin-resistant Staphylococcus aureus strains to meropenem and cloxacillin.
AID553734	Antimicrobial activity against Panton-valentine leukocidin positive community acquired methicillin-resistant Staphylococcus aureus NRS192 obtained from patient with pneumonia and septic arthritis infected in human THP-1 cells assessed as increase in bacte	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID444051	Total clearance in human	2010	Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3	Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
AID1079948	Times to onset, minimal and maximal, observed in the indexed observations. [column 'DELAI' in source]
AID278564	Antimicrobial activity against 90 mins hydrogen peroxide-stressed Bifidobacterium longum ATCC 15708 after 18 hrs	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID1533872	Antibacterial activity against multidrug-resistant Staphylococcus aureus isolate 774 by broth microdilution assay	2019	European journal of medicinal chemistry, Feb-01, Volume: 163	Boosting the efficacy of anti-MRSA β-lactam antibiotics via an easily accessible, non-cytotoxic and orally bioavailable FtsZ inhibitor.
AID523266	Activity at Escherichia coli isolate 7181 beta-lactamase OXA-7	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Kinetic parameters of efflux of penicillins by the multidrug efflux transporter AcrAB-TolC of Escherichia coli.
AID558327	Antibacterial activity against bla gene-positive and nitrocefin reaction-positive beta-lactamase harboring Campylobacter jejuni isolate P285 by NCCLS agar doubling dilution method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni.
AID1321403	Bactericidal activity against penicillin G-resistant/penicillinase producing Staphylococcus aureus isolate C1P15 by broth microdilution method	2016	Journal of medicinal chemistry, 10-13, Volume: 59, Issue:19	The Rational Design, Synthesis, and Antimicrobial Properties of Thiophene Derivatives That Inhibit Bacterial Histidine Kinases.
AID558336	Antibacterial activity against bla gene-positive and nitrocefin reaction-positive beta-lactamase harboring Campylobacter jejuni isolate P1618 by NCCLS agar doubling dilution method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni.
AID409958	Inhibition of bovine brain MAOA	2008	Journal of medicinal chemistry, Nov-13, Volume: 51, Issue:21	Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
AID524383	Antibacterial activity against Escherichia coli NKE161 harboring deletion mutation in acrB protein, vector expressing tolC gene and plasmid expressing nlpE gene	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Effect of NlpE overproduction on multidrug resistance in Escherichia coli.
AID553700	Antimicrobial activity against beta-lactamase negative methicillin-susceptible Staphylococcus aureus ATCC 25923 by broth microdilution method at pH 7.4	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID553713	Antimicrobial activity against beta-lactamase negative methicillin-susceptible Staphylococcus aureus ATCC 25923 by broth microdilution method at pH 5.5	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID553878	Antimicrobial activity against hospital acquired methicillin-resistant Staphylococcus aureus HMC546 infected in human THP-1 cells assessed as decrease in bacterial growth after 24 hrs at pH 5.5	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID553710	Antimicrobial activity against hospital acquired methicillin-resistant and vancomycin-intermediate Staphylococcus aureus NRS126 obtained from patient with bloodstream infection by broth microdilution method at pH 7.4	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID1246258	Antimicrobial activity against Staphylococcus aureus ATCC 25923 incubated for 20 hrs by serial dilution broth microplate method	2015	European journal of medicinal chemistry, Aug-28, Volume: 101	Imidazolidine-4-one derivatives in the search for novel chemosensitizers of Staphylococcus aureus MRSA: synthesis, biological evaluation and molecular modeling studies.
AID278543	Antimicrobial activity against 60 min 1 M HCl-stressed Bifidobacterium pseudolongum ATCC 25562 after 18 hrs	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID1533861	Antibacterial activity against multidrug-resistant Staphylococcus aureus isolate 2516 by broth microdilution assay	2019	European journal of medicinal chemistry, Feb-01, Volume: 163	Boosting the efficacy of anti-MRSA β-lactam antibiotics via an easily accessible, non-cytotoxic and orally bioavailable FtsZ inhibitor.
AID278538	Antimicrobial activity against 60 min 1 M HCl-stressed Bifidobacterium breve R0070 after 18 hrs	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID558333	Antibacterial activity against bla gene-positive and nitrocefin reaction-positive beta-lactamase harboring Campylobacter jejuni isolate P790 by NCCLS agar doubling dilution method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni.
AID553887	Bacteriostatic activity against hospital acquired methicillin-resistant Staphylococcus aureus ATCC 33591 infected in human THP-1 cells assessed as decrease in bacterial growth after 24 hrs at pH 5.5	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID553890	Bacteriostatic activity against hospital acquired methicillin-resistant Staphylococcus aureus N4120210 infected in human THP-1 cells assessed as decrease in bacterial growth after 24 hrs at pH 5.5	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID278549	Antimicrobial activity against 90 mins oxgall-stressed Bifidobacterium breve ATCC 15700 after 18 hrs	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID1533854	Antibacterial activity against multidrug-resistant Staphylococcus aureus isolate 2901 by broth microdilution assay	2019	European journal of medicinal chemistry, Feb-01, Volume: 163	Boosting the efficacy of anti-MRSA β-lactam antibiotics via an easily accessible, non-cytotoxic and orally bioavailable FtsZ inhibitor.
AID553888	Bacteriostatic activity against constitutive beta-lactamase negative methicillin-resistant Staphylococcus aureus COL NRS100 infected in human THP-1 cells assessed as decrease in bacterial growth after 24 hrs at pH 5.5	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID1079934	Highest frequency of acute liver toxicity observed during clinical trials, expressed as a percentage. [column '% AIGUE' in source]
AID553728	Antimicrobial activity against constitutive beta-lactamase negative methicillin-resistant Staphylococcus aureus COL NRS100 infected in human THP-1 cells assessed as increase in bacterial count from original inoculum at low compound concentration after 24	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID278542	Antimicrobial activity against 60 min 1 M HCl-stressed Bifidobacterium longum P/N 601377 after 18 hrs	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID558338	Antibacterial activity against bla gene-positive and nitrocefin reaction-positive beta-lactamase harboring Campylobacter jejuni isolate P1730 by NCCLS agar doubling dilution method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni.
AID604743	Displacement of radiolabeled warfarin from fatty acid containing human serum albumin site 1 in phosphate buffer at pH 7.4 at 12 uM by fluorescence spectroscopy	2010	Bioorganic & medicinal chemistry, Nov-01, Volume: 18, Issue:21	A combined spectroscopic and crystallographic approach to probing drug-human serum albumin interactions.
AID553876	Antimicrobial activity against hospital acquired methicillin-resistant Staphylococcus aureus N4120032 obtained from wound infection opf patient infected in human THP-1 cells assessed as decrease in bacterial growth after 24 hrs at pH 5.5	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID1533870	Antibacterial activity against multidrug-resistant Staphylococcus aureus isolate 358 by broth microdilution assay	2019	European journal of medicinal chemistry, Feb-01, Volume: 163	Boosting the efficacy of anti-MRSA β-lactam antibiotics via an easily accessible, non-cytotoxic and orally bioavailable FtsZ inhibitor.
AID553727	Antimicrobial activity against hospital acquired methicillin-resistant Staphylococcus aureus ATCC 33591 infected in human THP-1 cells assessed as increase in bacterial count from original inoculum at low compound concentration after 24 hrs at pH 5.5	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID558539	Antibacterial activity against bla gene-positive and nitrocefin reaction-positive beta-lactamase harboring Campylobacter coli isolate P1826 by NCCLS agar doubling dilution method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni.
AID1309045	Antifungal activity against clinical isolates of Candida albicans SC5314 after 48 hrs by broth microdilution method	2016	Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15	Synthesis of riccardin D derivatives as potent antimicrobial agents.
AID553669	Chemical stability of the compound assessed as compound remaining after 24 hrs in PBS buffer by HPLC analysis at pH 7.4	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID524388	Antibacterial activity against Escherichia coli NKE1366 harboring deletion mutation in acrB and vector expressing mdtABC gene	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Effect of NlpE overproduction on multidrug resistance in Escherichia coli.
AID553651	Bacteriostatic activity against intracellular beta-lactamase negative methicillin-susceptible Staphylococcus aureus ATCC 25923 infected in activated human THP-1 cells assessed as decrease in bacterial growth after 24 hrs at pH 7.4	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID553654	Antimicrobial activity against intracellular hospital acquired methicillin-resistant Staphylococcus aureus ATCC 33591 infected in human keratinocytes assessed as increase in bacterial count from original inoculum at low compound concentration after 24 hrs	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID558778	Antibacterial activity against tolC-deficient Salmonella enterica NKS174 by CLSI method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	H-NS modulates multidrug resistance of Salmonella enterica serovar Typhimurium by repressing multidrug efflux genes acrEF.
AID558337	Antibacterial activity against bla gene-positive and nitrocefin reaction-positive beta-lactamase harboring Campylobacter jejuni isolate P1650 by NCCLS agar doubling dilution method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni.
AID1079935	Cytolytic liver toxicity, either proven histopathologically or where the ratio of maximal ALT or AST activity above normal to that of Alkaline Phosphatase is > 5 (see ACUTE). Value is number of references indexed. [column 'CYTOL' in source]
AID323866	Antibacterial activity against methicillin-resistant Staphylococcus aureus 459 at pH 5.5	2007	Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5	Role of acidic pH in the susceptibility of intraphagocytic methicillin-resistant Staphylococcus aureus strains to meropenem and cloxacillin.
AID1246257	Antimicrobial activity against methicillin-resistant Staphylococcus aureus HEMSA incubated for 20 hrs by serial dilution broth microplate method	2015	European journal of medicinal chemistry, Aug-28, Volume: 101	Imidazolidine-4-one derivatives in the search for novel chemosensitizers of Staphylococcus aureus MRSA: synthesis, biological evaluation and molecular modeling studies.
AID278536	Antimicrobial activity against 60 min 1 M HCl-stressed Bifidobacterium bifidum BB12 after 18 hrs	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID1533856	Antibacterial activity against multidrug-resistant Staphylococcus aureus isolate 256 by broth microdilution assay	2019	European journal of medicinal chemistry, Feb-01, Volume: 163	Boosting the efficacy of anti-MRSA β-lactam antibiotics via an easily accessible, non-cytotoxic and orally bioavailable FtsZ inhibitor.
AID278526	Antimicrobial activity against Bifidobacterium infantis ATCC 15697	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID553893	Bacteriostatic activity against Panton-valentine leukocidin positive community acquired methicillin-resistant Staphylococcus aureus N4042228 infected in human THP-1 cells assessed as decrease in bacterial growth after 24 hrs at pH 5.5	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID554988	Antibacterial activity against Acinetobacter genomosp. 3 isolate 56 by Etest method	2009	Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3	Genetic variability among ampC genes from acinetobacter genomic species 3.
AID1449628	Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-taurocholate transport into vesicles incubated for 5 mins by Topcount based rapid filtration method	2012	Drug metabolism and disposition: the biological fate of chemicals, Dec, Volume: 40, Issue:12	Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
AID553658	Antimicrobial activity against intracellular hospital acquired methicillin-resistant Staphylococcus aureus ATCC 33591 infected in human keratinocytes assessed as decrease in bacterial growth after 24 hrs at pH 7.4	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID278559	Antimicrobial activity against 90 mins hydrogen peroxide-stressed Bifidobacterium bifidum R0071 after 18 hrs	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID553892	Bacteriostatic activity against Panton-valentine leukocidin positive community acquired methicillin-resistant Staphylococcus aureus N4090440 infected in human THP-1 cells assessed as decrease in bacterial growth after 24 hrs at pH 5.5	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID553898	Bacteriostatic activity against animal acquired methicillin-resistant Staphylococcus aureus N7112046 infected in human THP-1 cells assessed as decrease in bacterial growth after 24 hrs at pH 5.5	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID553897	Bacteriostatic activity against hospital acquired methicillin-resistant and vancomycin-intermediate Staphylococcus aureus VRS2 infected in human THP-1 cells assessed as decrease in bacterial growth after 24 hrs at pH 5.5	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID553894	Bacteriostatic activity against Panton-valentine leukocidin positive community acquired methicillin-resistant Staphylococcus aureus NRS192 infected in human THP-1 cells assessed as decrease in bacterial growth after 24 hrs at pH 5.5	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID553672	Antimicrobial activity against hospital acquired methicillin-resistant Staphylococcus aureus ATCC 33591 infected in human THP-1 cells assessed as increase in bacterial count from original inoculum at low compound concentration after 24 hrs at pH 7.4	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID558334	Antibacterial activity against bla gene-positive and nitrocefin reaction-positive beta-lactamase harboring Campylobacter jejuni isolate P1093 by NCCLS agar doubling dilution method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni.
AID553864	Antimicrobial activity against hospital acquired methicillin-resistant Staphylococcus aureus N4120210 obtained from urinary tract infection of patient infected in human THP-1 cells assessed as decrease in bacterial count from original inoculum at high com	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID612540	Binding affinity to human PepT2 in SKTP cells	2011	Bioorganic & medicinal chemistry, Aug-01, Volume: 19, Issue:15	Fragmental modeling of hPepT2 and analysis of its binding features by docking studies and pharmacophore mapping.
AID1533853	Antibacterial activity against multidrug-resistant Staphylococcus aureus isolate 1344 by broth microdilution assay	2019	European journal of medicinal chemistry, Feb-01, Volume: 163	Boosting the efficacy of anti-MRSA β-lactam antibiotics via an easily accessible, non-cytotoxic and orally bioavailable FtsZ inhibitor.
AID1533874	Antibacterial activity against multidrug-resistant Staphylococcus aureus isolate 2973 by broth microdilution assay	2019	European journal of medicinal chemistry, Feb-01, Volume: 163	Boosting the efficacy of anti-MRSA β-lactam antibiotics via an easily accessible, non-cytotoxic and orally bioavailable FtsZ inhibitor.
AID558328	Antibacterial activity against bla gene-positive and nitrocefin reaction-positive beta-lactamase harboring Campylobacter jejuni isolate P286 by NCCLS agar doubling dilution method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni.
AID553649	Antimicrobial activity against intracellular beta-lactamase negative methicillin-susceptible Staphylococcus aureus ATCC 25923 infected in activated human THP-1 cells assessed as decrease in bacterial growth after 24 hrs at pH 7.4	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID553865	Antimicrobial activity against hospital acquired methicillin-resistant Staphylococcus aureus HMC546 infected in human THP-1 cells assessed as decrease in bacterial count from original inoculum at high compound concentration after 24 hrs at pH 5.5	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID278561	Antimicrobial activity against 90 mins hydrogen peroxide-stressed Bifidobacterium breve ATCC 15700 after 18 hrs	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID553679	Ratio of intracellular to extracellular drug level in human THP1 cells at 250 mg/L after 24 hrs	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID553720	Antimicrobial activity against Panton-valentine leukocidin positive community acquired methicillin-resistant Staphylococcus aureus N4042228 by broth microdilution method at pH 5.5	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID555212	Antibacterial activity against Acinetobacter genomosp. 3 isolate 128 by Etest method	2009	Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3	Genetic variability among ampC genes from acinetobacter genomic species 3.
AID278546	Antimicrobial activity against 90 mins oxgall-stressed Bifidobacterium bifidum R0071 after 18 hrs	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID681115	TP_TRANSPORTER: inhibition of Gly-Sar uptake (pH6.0) in Caco-2 cells	2005	European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, Jan, Volume: 59, Issue:1	Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1.
AID553732	Antimicrobial activity against Panton-valentine leukocidin positive community acquired methicillin-resistant Staphylococcus aureus N4090440 obtained from wound infection of patient infected in human THP-1 cells assessed as increase in bacterial count from	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID558322	Antibacterial activity against bla gene-positive and nitrocefin reaction-negative beta-lactamase harboring Campylobacter jejuni NCTC 11168 by NCCLS agar doubling dilution method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni.
AID558782	Antibacterial activity against acrB-deficient Salmonella enterica NKS416 harboring acrEF, hns gene by CLSI method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	H-NS modulates multidrug resistance of Salmonella enterica serovar Typhimurium by repressing multidrug efflux genes acrEF.
AID531318	Ratio of Kcat to Km for Escherichia coli beta-lactamase VIM-1 by spectrophotometry	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Kinetic characterization of VIM-7, a divergent member of the VIM metallo-beta-lactamase family.
AID278537	Antimicrobial activity against 60 min 1 M HCl-stressed Bifidobacterium breve ATCC 15700 after 18 hrs	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID553709	Antimicrobial activity against hospital acquired methicillin-resistant and vancomycin-intermediate Staphylococcus aureus NRS18 obtained from patient with wound, skin and soft tissue infection by broth microdilution method at pH 7.4	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID478497	Antibacterial activity against Pseudomonas aeruginosa at 2 mg/ml after 24 hrs by agar diffusion method	2010	European journal of medicinal chemistry, May, Volume: 45, Issue:5	Synthesis and antimicrobial of new anthraquinone derivatives incorporating pyrazole moiety.
AID278550	Antimicrobial activity against 90 mins oxgall-stressed Bifidobacterium breve R0070 after 18 hrs	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID553673	Antimicrobial activity against beta-lactamase negative methicillin-susceptible Staphylococcus aureus ATCC 25923 infected in human THP-1 cells assessed as decrease in bacterial count from original inoculum at high compound concentration after 24 hrs at pH	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID553725	Antimicrobial activity against animal acquired methicillin-resistant Staphylococcus aureus N7112046 by broth microdilution method at pH 5.5	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID558335	Antibacterial activity against Campylobacter jejuni isolate P1093 harboring blaOXA-61::cat gene by NCCLS agar doubling dilution method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni.
AID553873	Antimicrobial activity against beta-lactamase negative methicillin-susceptible Staphylococcus aureus ATCC 25923 infected in human THP-1 cells assessed as decrease in bacterial growth after 24 hrs at pH 5.5	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID553733	Antimicrobial activity against Panton-valentine leukocidin positive community acquired methicillin-resistant Staphylococcus aureus N4042228 infected in human THP-1 cells assessed as increase in bacterial count from original inoculum at low compound concen	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID523269	Binding affinity to Escherichia coli isolate HN1157 AcrAB-TolC efflux transporter	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Kinetic parameters of efflux of penicillins by the multidrug efflux transporter AcrAB-TolC of Escherichia coli.
AID278544	Antimicrobial activity against 60 min 1 M HCl-stressed Bifidobacterium thermophilum ATCC 25866 after 18 hrs	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID560706	Inhibition of Escherichia coli MC4100 Beta-Lactamase CMY-2 using cephalothin as reporter substrate	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Extended-spectrum properties of CMY-30, a Val211Gly mutant of CMY-2 cephalosporinase.
AID278541	Antimicrobial activity against 60 min 1 M HCl-stressed Bifidobacterium longum R0175 after 18 hrs	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID553880	Antimicrobial activity against Panton-valentine leukocidin positive community acquired methicillin-resistant Staphylococcus aureus N4042228 infected in human THP-1 cells assessed as decrease in bacterial growth after 24 hrs at pH 5.5	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID524385	Antibacterial activity against Escherichia coli NKE156 harboring deletion mutation in acrB protein and vector expressing acrD gene	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Effect of NlpE overproduction on multidrug resistance in Escherichia coli.
AID1533866	Antibacterial activity against multidrug-resistant Staphylococcus aureus isolate 2919 by broth microdilution assay	2019	European journal of medicinal chemistry, Feb-01, Volume: 163	Boosting the efficacy of anti-MRSA β-lactam antibiotics via an easily accessible, non-cytotoxic and orally bioavailable FtsZ inhibitor.
AID1309044	Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate SDSM1503 after 24 hrs by broth microdilution method	2016	Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15	Synthesis of riccardin D derivatives as potent antimicrobial agents.
AID558324	Antibacterial activity against bla gene-negative and nitrocefin reaction-negative beta-lactamase harboring Campylobacter jejuni isolate P835 by NCCLS agar doubling dilution method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni.
AID1533851	Antibacterial activity against multidrug-resistant Staphylococcus aureus isolate 231 by broth microdilution assay	2019	European journal of medicinal chemistry, Feb-01, Volume: 163	Boosting the efficacy of anti-MRSA β-lactam antibiotics via an easily accessible, non-cytotoxic and orally bioavailable FtsZ inhibitor.
AID553716	Antimicrobial activity against hospital acquired methicillin-resistant Staphylococcus aureus N4120032 obtained from wound infection of patient by broth microdilution method at pH 5.5	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID278547	Antimicrobial activity against 90 mins oxgall-stressed Bifidobacterium bifidum ATCC 15696 after 18 hrs	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID278534	Antimicrobial activity against 60 min 1 M HCl-stressed Bifidobacterium animalis ATCC 27536 after 18 hrs	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID278562	Antimicrobial activity against 90 mins hydrogen peroxide-stressed Bifidobacterium breve R0070 after 18 hrs	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID553889	Bacteriostatic activity against hospital acquired methicillin-resistant Staphylococcus aureus N4120032 infected in human THP-1 cells assessed as decrease in bacterial growth after 24 hrs at pH 5.5	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID278552	Antimicrobial activity against 90 mins oxgall-stressed Bifidobacterium longum ATCC 15707 after 18 hrs	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID1079939	Cirrhosis, proven histopathologically. Value is number of references indexed. [column 'CIRRH' in source]
AID1079940	Granulomatous liver disease, proven histopathologically. Value is number of references indexed. [column 'GRAN' in source]
AID369966	Antibacterial activity against methicillin-resistant Staphylococcus aureus by broth microdilution technique	2007	Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9	In vivo efficacy of moxifloxacin compared with cloxacillin and vancomycin in a Staphylococcus aureus rabbit arthritis experimental model.
AID558536	Antibacterial activity against bla gene-negative and nitrocefin reaction-positive beta-lactamase harboring Campylobacter jejuni isolate P854 by NCCLS agar doubling dilution method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni.
AID524260	Antibacterial activity against Escherichia coli NKE96 harboring deletion mutation in acrB protein	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Effect of NlpE overproduction on multidrug resistance in Escherichia coli.
AID524392	Antibacterial activity against Escherichia coli NKE1369 harboring deletion mutation in acrB, acrD, mdtABC protein and plasmid expressing nlpE gene	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Effect of NlpE overproduction on multidrug resistance in Escherichia coli.
AID553875	Antimicrobial activity against constitutive beta-lactamase negative methicillin-resistant Staphylococcus aureus COL NRS100 infected in human THP-1 cells assessed as decrease in bacterial growth after 24 hrs at pH 5.5	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID531316	Ratio of Kcat to Km for Pseudomonas aeruginosa beta-lactamase VIM-2 by spectrophotometry	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Kinetic characterization of VIM-7, a divergent member of the VIM metallo-beta-lactamase family.
AID38399	Binding affinity towards AmpC beta-lactamase binding site from Escherichia coli; NA means not applicable	2002	Journal of medicinal chemistry, Jul-18, Volume: 45, Issue:15	Structure-based approach for binding site identification on AmpC beta-lactamase.
AID1533875	Antibacterial activity against multidrug-resistant Staphylococcus aureus isolate 85 by broth microdilution assay	2019	European journal of medicinal chemistry, Feb-01, Volume: 163	Boosting the efficacy of anti-MRSA β-lactam antibiotics via an easily accessible, non-cytotoxic and orally bioavailable FtsZ inhibitor.
AID604742	Displacement of radiolabeled dansylsarcosine from fatty acid-free human serum albumin site 2 in phosphate buffer at pH 7.4 at 12 uM by fluorescence spectroscopy	2010	Bioorganic & medicinal chemistry, Nov-01, Volume: 18, Issue:21	A combined spectroscopic and crystallographic approach to probing drug-human serum albumin interactions.
AID1209732	Drug uptake by mouse OAT3 expressed in CHO cells at 100 uM after 25 mins by HPLC/UV detection method in presence of probenecid	2013	Drug metabolism and disposition: the biological fate of chemicals, Apr, Volume: 41, Issue:4	Organic anion transporter 3 interacts selectively with lipophilic β-lactam antibiotics.
AID523272	Antimicrobial activity against Escherichia coli HN1157/pHSG576oxa7 assessed as minimal drug concentration	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Kinetic parameters of efflux of penicillins by the multidrug efflux transporter AcrAB-TolC of Escherichia coli.
AID1533865	Antibacterial activity against multidrug-resistant Staphylococcus aureus isolate 1402 by broth microdilution assay	2019	European journal of medicinal chemistry, Feb-01, Volume: 163	Boosting the efficacy of anti-MRSA β-lactam antibiotics via an easily accessible, non-cytotoxic and orally bioavailable FtsZ inhibitor.
AID524266	Antibacterial activity against Escherichia coli NKE128 harboring deletion mutation in acrB and tolC protein	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Effect of NlpE overproduction on multidrug resistance in Escherichia coli.
AID1533859	Antibacterial activity against multidrug-resistant Staphylococcus aureus isolate 1136 by broth microdilution assay	2019	European journal of medicinal chemistry, Feb-01, Volume: 163	Boosting the efficacy of anti-MRSA β-lactam antibiotics via an easily accessible, non-cytotoxic and orally bioavailable FtsZ inhibitor.
AID1209455	Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake	2012	Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 40, Issue:1	In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
AID553717	Antimicrobial activity against hospital acquired methicillin-resistant Staphylococcus aureus N4120210 obtained from urinary tract infection patient by broth microdilution method at pH 5.5	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID553738	Antimicrobial activity against animal acquired methicillin-resistant Staphylococcus aureus N7112046 infected in human THP-1 cells assessed as increase in bacterial count from original inoculum at low compound concentration after 24 hrs at pH 5.5	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID325445	Antibacterial activity against Escherichia coli C921-61 after 14 to 16 hrs by broth dilution method	2007	Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6	Polyamine effects on antibiotic susceptibility in bacteria.
AID524390	Antibacterial activity against Escherichia coli NKE1316 harboring deletion mutation in acrB, acrD and mdtABC protein	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Effect of NlpE overproduction on multidrug resistance in Escherichia coli.
AID1209736	Inhibition of human OAT3 expressed in CHO cells assessed as inhibition of fluorescein uptake at 500 uM over 20 mins relative to untreated-control	2013	Drug metabolism and disposition: the biological fate of chemicals, Apr, Volume: 41, Issue:4	Organic anion transporter 3 interacts selectively with lipophilic β-lactam antibiotics.
AID1533860	Antibacterial activity against multidrug-resistant Staphylococcus aureus isolate 2895 by broth microdilution assay	2019	European journal of medicinal chemistry, Feb-01, Volume: 163	Boosting the efficacy of anti-MRSA β-lactam antibiotics via an easily accessible, non-cytotoxic and orally bioavailable FtsZ inhibitor.
AID555208	Antibacterial activity against Acinetobacter genomosp. 3 isolate 69 by Etest method	2009	Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3	Genetic variability among ampC genes from acinetobacter genomic species 3.
AID553712	Antimicrobial activity against animal acquired methicillin-resistant Staphylococcus aureus N7112046 by broth microdilution method at pH 7.4	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID558323	Antibacterial activity against Campylobacter jejuni isolate P270 harboring blaOXA-61::cat gene by NCCLS agar doubling dilution method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni.
AID523270	Permeability across Escherichia coli HN1157/pHSG576oxa7 assessed as permeability coefficient in presence of proton uncoupler carbonyl cyanide meta-chlorophenylhydrazone	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Kinetic parameters of efflux of penicillins by the multidrug efflux transporter AcrAB-TolC of Escherichia coli.
AID278556	Antimicrobial activity against 90 mins oxgall-stressed Bifidobacterium pseudolongum ATCC 25562 after 18 hrs	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID553724	Antimicrobial activity against hospital acquired methicillin-resistant and vancomycin-intermediate Staphylococcus aureus VRS2 obtained from patient with wound, skin and soft tissue infection by broth microdilution method at pH 5.5	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID558331	Antibacterial activity against bla gene-positive and nitrocefin reaction-positive beta-lactamase harboring Campylobacter jejuni isolate P338 by NCCLS agar doubling dilution method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni.
AID278545	Antimicrobial activity against 90 mins oxgall-stressed Bifidobacterium animalis ATCC 27536 after 18 hrs	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID553718	Antimicrobial activity against hospital acquired methicillin-resistant Staphylococcus aureus HMC546 by broth microdilution method at pH 5.5	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID1533873	Antibacterial activity against multidrug-resistant Staphylococcus aureus isolate 200 by broth microdilution assay	2019	European journal of medicinal chemistry, Feb-01, Volume: 163	Boosting the efficacy of anti-MRSA β-lactam antibiotics via an easily accessible, non-cytotoxic and orally bioavailable FtsZ inhibitor.
AID553715	Antimicrobial activity against constitutive beta-lactamase negative methicillin-resistant Staphylococcus aureus COL NRS100 by broth microdilution method at pH 5.5	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID278530	Antimicrobial activity against Bifidobacterium longum P/N 601377	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID1079949	Proposed mechanism(s) of liver damage. [column 'MEC' in source]
AID1321393	Antibacterial activity against penicillin G-resistant/penicillinase producing Staphylococcus aureus isolate C1P15 by broth microdilution method	2016	Journal of medicinal chemistry, 10-13, Volume: 59, Issue:19	The Rational Design, Synthesis, and Antimicrobial Properties of Thiophene Derivatives That Inhibit Bacterial Histidine Kinases.
AID444053	Renal clearance in human	2010	Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3	Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
AID553891	Bacteriostatic activity against hospital acquired methicillin-resistant Staphylococcus aureus HMC546 infected in human THP-1 cells assessed as decrease in bacterial growth after 24 hrs at pH 5.5	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID325446	Antibacterial activity against Salmonella enterica serovar Typhimurium LT2 after 14 to 16 hrs by broth dilution method	2007	Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6	Polyamine effects on antibiotic susceptibility in bacteria.
AID558535	Antibacterial activity against bla gene-negative and nitrocefin reaction-positive beta-lactamase harboring Campylobacter jejuni isolate P843 by NCCLS agar doubling dilution method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni.
AID1321402	Bactericidal activity against Staphylococcus aureus ATCC 29213 by broth microdilution method	2016	Journal of medicinal chemistry, 10-13, Volume: 59, Issue:19	The Rational Design, Synthesis, and Antimicrobial Properties of Thiophene Derivatives That Inhibit Bacterial Histidine Kinases.
AID660262	Ratio of MIC for wild type Escherichia coli TG1 to MIC for acrB-deficient Escherichia coli KAM3 by two-fold serial dilution method	2012	European journal of medicinal chemistry, Jun, Volume: 52	Computational analysis of structure-based interactions and ligand properties can predict efflux effects on antibiotics.
AID553740	Antimicrobial activity against hospital acquired methicillin-resistant Staphylococcus aureus ATCC 33591 infected in human THP-1 cells assessed as decrease in bacterial count from original inoculum at high compound concentration after 24 hrs at pH 5.5	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID523268	Activity at Escherichia coli isolate HN1157 AcrAB-TolC efflux transporter	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Kinetic parameters of efflux of penicillins by the multidrug efflux transporter AcrAB-TolC of Escherichia coli.
AID553867	Antimicrobial activity against Panton-valentine leukocidin positive community acquired methicillin-resistant Staphylococcus aureus N4042228 infected in human THP-1 cells assessed as decrease in bacterial count from original inoculum at high compound conce	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID278528	Antimicrobial activity against Bifidobacterium longum ATCC 15708	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID553735	Antimicrobial activity against hospital acquired methicillin-resistant and vancomycin-intermediate Staphylococcus aureus NRS18 obtained from wound, skin and soft tissue infection of patient infected in human THP-1 cells assessed as increase in bacterial c	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID1533858	Antibacterial activity against multidrug-resistant Staphylococcus aureus isolate 3411 by broth microdilution assay	2019	European journal of medicinal chemistry, Feb-01, Volume: 163	Boosting the efficacy of anti-MRSA β-lactam antibiotics via an easily accessible, non-cytotoxic and orally bioavailable FtsZ inhibitor.
AID553664	Antimicrobial activity against intracellular hospital acquired methicillin-resistant Staphylococcus aureus ATCC 33591 infected in human Calu3 cells assessed as decrease in bacterial count from original inoculum at high compound concentration after 24 hrs	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID553653	Antimicrobial activity against intracellular beta-lactamase negative methicillin-susceptible Staphylococcus aureus ATCC 25923 infected in human keratinocytes assessed as increase in bacterial count from original inoculum at low compound concentration afte	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID553708	Antimicrobial activity against Panton-valentine leukocidin positive community acquired methicillin-resistant Staphylococcus aureus NRS192 obtained from patient with pneumonia and septic arthritis by broth microdilution method at pH 7.4	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID553652	Bacteriostatic activity against intracellular hospital acquired methicillin-resistant Staphylococcus aureus ATCC 33591 infected in activated human THP-1 cells assessed as decrease in bacterial growth after 24 hrs at pH 7.4	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID444052	Hepatic clearance in human	2010	Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3	Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
AID553869	Antimicrobial activity against hospital acquired methicillin-resistant and vancomycin-intermediate Staphylococcus aureus NRS18 obtained from wound, skin and soft tissue infection of patient infected in human THP-1 cells assessed as decrease in bacterial c	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID523271	Lipophilicity, log P of the compound	2010	Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5	Kinetic parameters of efflux of penicillins by the multidrug efflux transporter AcrAB-TolC of Escherichia coli.
AID278551	Antimicrobial activity against 90 mins oxgall-stressed Bifidobacterium infantis ATCC 15697 after 18 hrs	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID1533867	Antibacterial activity against multidrug-resistant Staphylococcus aureus isolate 2728 by broth microdilution assay	2019	European journal of medicinal chemistry, Feb-01, Volume: 163	Boosting the efficacy of anti-MRSA β-lactam antibiotics via an easily accessible, non-cytotoxic and orally bioavailable FtsZ inhibitor.
AID553707	Antimicrobial activity against Panton-valentine leukocidin positive community acquired methicillin-resistant Staphylococcus aureus N4042228 by broth microdilution method at pH 7.4	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID1533857	Antibacterial activity against multidrug-resistant Staphylococcus aureus isolate 3332 by broth microdilution assay	2019	European journal of medicinal chemistry, Feb-01, Volume: 163	Boosting the efficacy of anti-MRSA β-lactam antibiotics via an easily accessible, non-cytotoxic and orally bioavailable FtsZ inhibitor.
AID553862	Antimicrobial activity against constitutive beta-lactamase negative methicillin-resistant Staphylococcus aureus COL NRS100 infected in human THP-1 cells assessed as decrease in bacterial count from original inoculum at high compound concentration after 24	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID553896	Bacteriostatic activity against hospital acquired methicillin-resistant and vancomycin-intermediate Staphylococcus aureus NRS126 infected in human THP-1 cells assessed as decrease in bacterial growth after 24 hrs at pH 5.5	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID278563	Antimicrobial activity against 90 mins hydrogen peroxide-stressed Bifidobacterium longum ATCC 15707 after 18 hrs	2007	Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1	Antibiotic susceptibility profile of bifidobacteria as affected by oxgall, acid, and hydrogen peroxide stress.
AID553677	Bacteriostatic activity against beta-lactamase negative methicillin-susceptible Staphylococcus aureus ATCC 25923 infected in human THP-1 cells assessed as decrease in bacterial growth after 24 hrs at pH 7.4	2008	Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8	Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
AID555210	Antibacterial activity against Acinetobacter genomosp. 3 isolate 103 by Etest method	2009	Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3	Genetic variability among ampC genes from acinetobacter genomic species 3.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1073 (66.90)	18.7374
1990's	172 (10.72)	18.2507
2000's	165 (10.29)	29.6817
2010's	146 (9.10)	24.3611
2020's	48 (2.99)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	155 (9.04%)	5.53%
Reviews	52 (3.03%)	6.00%
Case Studies	271 (15.80%)	4.05%
Observational	0 (0.00%)	0.25%
Other	1,237 (72.13%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Trial	Phase	Enrollment	Study Type	Start Date	Status
Prospective Randomized Study to Compare Clinical Outcomes in Patients With Osteomyelitis Treated With Intravenous Antibiotics Versus Intravenous Antibiotics With an Early Switch to Oral Antibiotics[NCT02099240]	Early Phase 1	11 participants (Actual)	Interventional	2014-03-06	Terminated(stopped due to Not enough patient enrollment and lack of staffing)
A Multicenter Non-inferiority Randomized Trial Comparing Cloxacillin Versus Cefazolin Efficacy for the Treatment of Bacteremia Caused by Methicillin-susceptible Staphylococcus Aureus (MSSA)[NCT03248063]		315 participants (Actual)	Interventional	2018-09-05	Active, not recruiting
Phase 2/3 Evaluation of Three Lactobacilli Strains Isolated From Human Milk for the Treatment of Infectious Mastitis During the Lactation Period[NCT00716183]	Phase 2/Phase 3	300 participants (Actual)	Interventional	2008-07-31	Completed
A Phase 2, Randomized, Double-Blind, Parallel-Group, Multinational Trial of Intravenous Televancin (TD-6424) for Treatment of Uncomplicated Staphylococcus Aureus Bacteremia[NCT00062647]	Phase 2	60 participants (Actual)	Interventional	2003-08-31	Completed
Ceftriaxone as Home Intravenous Therapy for Deep-Seated Staphylococcal Infections, a Randomized Non-Inferiority Trial[NCT04141787]	Phase 4	310 participants (Anticipated)	Interventional	2019-07-11	Recruiting
A Multi-Center, Randomized, Open-Label, Comparative Study to Assess the Safety and Efficacy of a Treatment Algorithm to Reduce the Use of Vancomycin in Adult Patients With Blood Stream Infections Due to Staphylococci[NCT01191840]	Phase 2	509 participants (Actual)	Interventional	2011-02-28	Completed
Efficacy of a Short-term Sequential Therapy Versus Intravenous Standard Treatment for Patients With Non-complicated Catheter Related Bacteremia by Methicillin- Susceptible S.Aureus.[NCT01875263]	Phase 3	1 participants (Actual)	Interventional	2013-05-31	Terminated(stopped due to Not participants inclusion)
Cloxacillin as Prevention of Double Lumen Infection in Hemodialysis Patients[NCT00885300]		100 participants (Actual)	Interventional	2008-01-31	Completed
An Evaluation of the Safety, Efficacy and Pharmacokinetics of Daptomycin in Pediatric Subjects Aged One to Seventeen Years With Complicated Skin and Skin Structure Infections Caused by Gram-Positive Pathogens[NCT00711802]	Phase 4	396 participants (Actual)	Interventional	2008-07-23	Completed
An Open Label, Multi-center, Randomized, Comparative Phase IIIb Study to Compare Efficacy and Safety of Intravenous (i.v.) Daptomycin With That of Semi-Synthetic Penicillins (SSPs) or Vancomycin in the Treatment of Elderly Patients (Aged ≥ 65 Years) With [NCT01184872]	Phase 3	120 participants (Actual)	Interventional	2010-03-31	Completed
Rifampin Combination Therapy Versus Monotherapy in Early Staphylococcal Infections After Total Hip and Knee Arthroplasty[NCT00423982]	Phase 4	100 participants (Anticipated)	Interventional	2006-04-30	Active, not recruiting
A Prospective, Multicenter, Randomized, Evaluator-blinded, Comparator-controlled Study to Describe the Safety and Efficacy of Daptomycin for the Treatment of Complicated Skin and Skin Structure Infections (cSSSI) and Staphylococcus Aureus Bacteremia Among[NCT01104662]	Phase 4	92 participants (Actual)	Interventional	2010-04-19	Terminated(stopped due to Cubist has reached an agreement with the FDA that enrollment in the DAP-RENSE-08-05 study can stop.)
Comparison of Efficacy, Safety and Economic Outcomes Between Once-Daily Versus Twice-Daily Amikacin in Combination With Cloxacillin in Febrile Neutropenic Children[NCT00129688]		166 participants	Interventional	2002-04-30	Completed
Undisplaced Femoral Neck Fractures in Patients Aged 70 Years and Older: A Multicentre Randomised Controlled Trial Comparing Internal Fixation to Hemiarthroplasty[NCT01770769]		220 participants (Actual)	Interventional	2012-02-06	Active, not recruiting
Early Oral Switch Therapy in Low-risk Staphylococcus Aureus Bloodstream Infection[NCT01792804]	Phase 3	215 participants (Actual)	Interventional	2013-12-31	Completed
CAMERA 2 - Combination Antibiotic Therapy for Methicillin Resistant Staphylococcus Aureus Infection - An Investigator-initiated, Multi-centre, Parallel Group, Open Labelled Randomised Controlled Trial[NCT02365493]	Phase 3	358 participants (Actual)	Interventional	2015-08-26	Terminated(stopped due to Recommendation of the Data Safety Monitoring Committee)
Pharmacological Comparison of Continuous and Intermittent Infusions of Cloxacillin During Bone and Joint Infections: a Prospective, Randomized, Open-label, Monocentric Crossover Study.[NCT03246360]		12 participants (Actual)	Interventional	2017-11-23	Completed
A Phase 3 Multicenter, Randomized, Open-label, Clinical Trial of Telavancin Versus Standard Intravenous Therapy in the Treatment of Subjects With Staphylococcus Aureus Bacteremia Including Infective Endocarditis[NCT02208063]	Phase 3	121 participants (Actual)	Interventional	2014-12-31	Terminated(stopped due to Halted due to lack of statistical power. No safety concerns identified.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Intervention	participants (Number)
	Cured	Failure
Standard Therapy	8	1
Telavancin	7	1

Intervention	Participants (Count of Participants)
Standard of Care	207
Algorithm-determined Therapy	209

Intervention	Days (Mean)
	PP Population	PPE Population
Algorithm-determined Therapy	7.5	4.4
Standard of Care	7.9	6.2

Intervention	microgramhour per milliliter (μghr/mL) (Mean)
Age Group 1: Daptomycin	318
Age Group 2: Daptomycin	NA
Age Group 3: Daptomycin	318
Age Group 4: Daptomycin	466

Intervention	percentage of participants (Number)
	Clinical success	Clinical failure	Unable to evaluate
Age Group 1: Daptomycin	95.9	0	4.1
Age Group 1: Standard of Care (SOC)	91.9	2.7	5.4
Age Group 2: Daptomycin	90.4	2.7	6.9
Age Group 2: SOC	92.1	0	7.9
Age Group 3: Daptomycin	82.7	1.2	16.1
Age Group 3: SOC	76.2	0	23.8
Age Group 4: Daptomycin	80.0	0	20.0
Age Group 4: SOC	86.7	0	13.3

Intervention	percentage of participants (Number)
	At least 1 TEAE	At least 1 drug-related TEAE	Discontinued treatment due to a TEAE
Age Group 1: Daptomycin	36.1	13.9	2.8
Age Group 1: Standard of Care (SOC)	36.8	10.5	0
Age Group 2: Daptomycin	23.3	5.5	1.4
Age Group 2: SOC	18.4	10.5	0
Age Group 3: Daptomycin	50.6	22.2	3.7
Age Group 3: SOC	38.1	21.4	14.3
Age Group 4: Daptomycin	46.7	10.0	3.3
Age Group 4: SOC	73.3	33.3	6.7

Intervention	Days (Mean)
Daptomycin	7.8
Vancomycin or Semi-Synthetic Penicillins (SSPs)	7.3

Intervention	Days (Mean)
	intravenous only	intravenous + oral
Daptomycin	7.8	8.7
Vancomycin or Semi-Synthetic Penicillins (SSPs)	7.3	9.6

Intervention	participants (Number)
	Success	Failure
Daptomycin	54	11
Vancomycin or Semi-Synthetic Penicillins (SSPs)	23	4

Intervention	participants (Number)
	Adverse Events	Serious Adverse Events	Death
Daptomycin	50	7	0
Vancomycin or Semi-Synthetic Penicillins (SSPs)	26	4	0

Intervention	participants (Number)
Daptomycin, Bacteremia, Severe Renal Impairment	0
Vancomycin or SSP, Bacteremia, Severe Renal Impairment	1
Daptomycin, Bacteremia, Moderate Renal Impairment	0
Vancomycin or SSP, Bacteremia, Moderate Renal Impairment	0
Daptomycin, cSSSI, Severe Renal Impairment	1
Vancomycin or SSP, cSSSI, Severe Renal Impairment	0
Daptomycin, cSSSI, Moderate Renal Impairment	0
Vancomycin or SSP, cSSSI, Moderate Renal Impairment	0

Intervention	participants (Number)
	Success	Failure	Non-evaluable
Daptomycin, Bacteremia, Moderate Renal Impairment	1	2	1
Daptomycin, Bacteremia, Severe Renal Impairment	9	2	4
Daptomycin, cSSSI, Moderate Renal Impairment	5	0	0
Daptomycin, cSSSI, Severe Renal Impairment	10	3	2
Vancomycin or SSP, Bacteremia, Moderate Renal Impairment	3	0	1
Vancomycin or SSP, Bacteremia, Severe Renal Impairment	9	1	6
Vancomycin or SSP, cSSSI, Moderate Renal Impairment	4	2	0
Vancomycin or SSP, cSSSI, Severe Renal Impairment	9	2	4

Substance	Description	Relationhip Strength	Studies	Trials	Classes	Roles
penicillin g	[no description available]	high	273	7	penicillin allergen; penicillin	antibacterial drug; drug allergen; epitope
penicillin g	[no description available]	high	273	0	penicillin allergen; penicillin	antibacterial drug; drug allergen; epitope
sulbactam	[no description available]	medium	8	0	penicillanic acids
sulbactam	[no description available]	medium	8	1	penicillanic acids
clavulanic acid	[no description available]	high	20	0	oxapenam	antibacterial drug; anxiolytic drug; bacterial metabolite; EC 3.5.2.6 (beta-lactamase) inhibitor
cinoxacin	[no description available]	medium	1	0	cinnolines; oxacycle; oxo carboxylic acid	antibacterial drug; antiinfective agent
norfloxacin	[no description available]	high	4	0	fluoroquinolone antibiotic; N-arylpiperazine; quinolinemonocarboxylic acid; quinolone antibiotic; quinolone	antibacterial drug; DNA synthesis inhibitor; environmental contaminant; xenobiotic
ofloxacin	[no description available]	medium	9	0	3-oxo monocarboxylic acid; N-arylpiperazine; N-methylpiperazine; organofluorine compound; oxazinoquinoline
ofloxacin	[no description available]	medium	9	1	3-oxo monocarboxylic acid; N-arylpiperazine; N-methylpiperazine; organofluorine compound; oxazinoquinoline
cephaloridine	[no description available]	high	82	2	beta-lactam antibiotic allergen; cephalosporin; semisynthetic derivative	antibacterial drug
cephaloridine	[no description available]	high	82	0	beta-lactam antibiotic allergen; cephalosporin; semisynthetic derivative	antibacterial drug
chloramphenicol	[no description available]	high	82	3	C-nitro compound; carboxamide; diol; organochlorine compound	antibacterial drug; antimicrobial agent; Escherichia coli metabolite; geroprotector; Mycoplasma genitalium metabolite; protein synthesis inhibitor
chloramphenicol	[no description available]	high	82	0	C-nitro compound; carboxamide; diol; organochlorine compound	antibacterial drug; antimicrobial agent; Escherichia coli metabolite; geroprotector; Mycoplasma genitalium metabolite; protein synthesis inhibitor
cephalothin	[no description available]	high	95	5	azabicycloalkene; beta-lactam antibiotic allergen; carboxylic acid; cephalosporin; semisynthetic derivative; thiophenes	antibacterial drug; antimicrobial agent
cephalothin	[no description available]	high	95	0	azabicycloalkene; beta-lactam antibiotic allergen; carboxylic acid; cephalosporin; semisynthetic derivative; thiophenes	antibacterial drug; antimicrobial agent
nafcillin	[no description available]	high	76	2	penicillin allergen; penicillin	antibacterial drug
nafcillin	[no description available]	high	76	0	penicillin allergen; penicillin	antibacterial drug
vancomycin	[no description available]	high	57	5	glycopeptide	antibacterial drug; antimicrobial agent; bacterial metabolite
vancomycin	[no description available]	high	57	0	glycopeptide	antibacterial drug; antimicrobial agent; bacterial metabolite
streptomycin	[no description available]	high	52	1	antibiotic antifungal drug; antibiotic fungicide; streptomycins	antibacterial drug; antifungal agrochemical; antimicrobial agent; antimicrobial drug; bacterial metabolite; protein synthesis inhibitor
streptomycin	[no description available]	high	52	0	antibiotic antifungal drug; antibiotic fungicide; streptomycins	antibacterial drug; antifungal agrochemical; antimicrobial agent; antimicrobial drug; bacterial metabolite; protein synthesis inhibitor
carbenicillin	[no description available]	high	71	2	penicillin allergen; penicillin	antibacterial drug
carbenicillin	[no description available]	high	71	0	penicillin allergen; penicillin	antibacterial drug
cephalexin	[no description available]	high	35	0	beta-lactam antibiotic allergen; cephalosporin; semisynthetic derivative	antibacterial drug
cefazolin	[no description available]	high	37	7	beta-lactam antibiotic allergen; cephalosporin; tetrazoles; thiadiazoles	antibacterial drug
cefazolin	[no description available]	high	37	0	beta-lactam antibiotic allergen; cephalosporin; tetrazoles; thiadiazoles	antibacterial drug
amoxicillin	[no description available]	high	80	9	penicillin allergen; penicillin	antibacterial drug
amoxicillin	[no description available]	high	80	0	penicillin allergen; penicillin	antibacterial drug
piperacillin	[no description available]	high	27	2	penicillin allergen; penicillin	antibacterial drug
piperacillin	[no description available]	high	27	0	penicillin allergen; penicillin	antibacterial drug
cefadroxil anhydrous	[no description available]	high	8	0	cephalosporin	antibacterial drug
cefamandole	[no description available]	high	16	2	cephalosporin; semisynthetic derivative	antibacterial drug
cefamandole	[no description available]	high	16	0	cephalosporin; semisynthetic derivative	antibacterial drug
ceftriaxone	[no description available]	medium	10	0	1,2,4-triazines; 1,3-thiazoles; cephalosporin; oxime O-ether	antibacterial drug; drug allergen; EC 3.5.2.6 (beta-lactamase) inhibitor
ceftazidime	[no description available]	medium	14	0	cephalosporin; oxime O-ether	antibacterial drug; drug allergen; EC 2.4.1.129 (peptidoglycan glycosyltransferase) inhibitor
cefotaxime	[no description available]	high	40	4	1,3-thiazoles; cephalosporin; oxime O-ether	antibacterial drug; drug allergen
cefotaxime	[no description available]	high	40	0	1,3-thiazoles; cephalosporin; oxime O-ether	antibacterial drug; drug allergen
gentamicin sulfate	[no description available]	medium	3	0
3-nitrobenzeneboronic acid	[no description available]	medium	1	0
benzo(b)thiophene-2-boronic acid	[no description available]	medium	1	0

Article	Year
Risk Factors for Nephrotoxicity in Methicillin-Resistant Staphylococcus aureus Bacteraemia: A Post Hoc Analysis of the CAMERA2 Trial. Clinical drug investigation, Volume: 43, Issue: 1	2023
Cloxacillin induced agranulocytosis: A rare adverse event of a commonly used antibiotic. International journal of immunopathology and pharmacology, Volume: 30, Issue: 3	2017
Clinical ototoxicity of teicoplanin. The Annals of otology, rhinology, and laryngology, Volume: 113, Issue: 4	2004
[Hepatotoxicity caused by cloxacillin]. Revista espanola de enfermedades digestivas, Volume: 89, Issue: 7	1997
Staphylococcal septicaemia complicated by probable cloxacillin neurotoxicity and by jaundice induced by fusidic acid. Scottish medical journal, Volume: 28, Issue: 2	1983
Cerebral toxicity of penicillins in relation to their hydrophobic character. Naunyn-Schmiedeberg's archives of pharmacology, Volume: 289, Issue: 1	1975
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Intervention	Participants (Count of Participants)
	Success	Failure	Indeterminate	Missing
Standard of Care	36	15	0	1
Telavancin	28	13	5	1

Intervention	Participants (Count of Participants)
	Cure	Failure	Indeterminate
Standard of Care	27	21	4
Telavancin	22	19	6

Article	Year
Pharmacokinetic-Pharmacodynamic Study of Ampicillin-Cloxacillin Combination in Indian Thoroughbred Horses (Equus caballus) and Safety Evaluation of the Computed Dosage Regimen. Journal of equine veterinary science, Volume: 115	2022
Significant Pharmacokinetic Interactions Between Quinine and Ampicillin-Cloxacillin Combination. Drugs in R&D, Volume: 16, Issue: 2	2016
Saliva versus plasma pharmacokinetics: theory and application of a salivary excretion classification system. Molecular pharmaceutics, Aug-06, Volume: 9, Issue: 8	2012
Effect of multidrug resistance gene-1 (ABCB1) polymorphisms on the single-dose pharmacokinetics of cloxacillin in healthy adult Chinese men. Clinical therapeutics, Volume: 31, Issue: 5	2009
Effect of probenecid on the apparent volume of distribution and elimination of cloxacillin. Antimicrobial agents and chemotherapy, Volume: 6, Issue: 3	1974
Large-volume sample stacking combined with separation by 2-hydroxypropyl-beta-cyclodextrin for analysis of isoxyzolylpenicillins by capillary electrophoresis. Electrophoresis, Volume: 24, Issue: 17	2003
Simultaneous spectrophotometric and volumetric determinations of amoxycillin, ampicillin and cloxacillin in drug formulations: reaction mechanism in the base catalysed hydrolysis followed by oxidation with iodate in dilute acid solution. Journal of pharmaceutical and biomedical analysis, Volume: 21, Issue: 3	1999
Pharmacokinetic and pharmacodynamic models of the antistaphylococcal effects of meropenem and cloxacillin in vitro and in experimental infection. Antimicrobial agents and chemotherapy, Volume: 41, Issue: 10	1997
Pharmacokinetics of cloxacillin in patients undergoing hip or knee replacement. European journal of clinical pharmacology, Volume: 52, Issue: 5	1997
No effect of diclofenac on the pharmacokinetics of cloxacillin. Pharmacology & toxicology, Volume: 81, Issue: 1	1997
Clinical pharmacokinetics of continuous intravenous administration of penicillins. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Volume: 17, Issue: 3	1993
Pharmacokinetics and distribution of flucloxacillin in pacemaker patients. European journal of clinical pharmacology, Volume: 27, Issue: 6	1985
Pharmacokinetics of free and total flucloxacillin in newborn infants. European journal of clinical pharmacology, Volume: 32, Issue: 4	1987
Digital subtraction chromatography: an LC-technique to reduce disturbing peaks in bioanalysis. Journal of pharmaceutical and biomedical analysis, Volume: 7, Issue: 1	1989
Pharmacokinetic analysis of cloxacillin loss in children undergoing major surgery with massive bleeding. Antimicrobial agents and chemotherapy, Volume: 34, Issue: 6	1990
[Pharmacokinetics and clinical effects of cefdinir 10% fine granules in pediatrics]. The Japanese journal of antibiotics, Volume: 45, Issue: 1	1992
Pharmacokinetics of flucloxacillin and cloxacillin in healthy subjects and patients on chronic intermittent haemodialysis. British journal of clinical pharmacology, Volume: 2, Issue: 2	1975
Pharmacokinetic aspects of streptomycin treatment of neonatal septicemia. Scandinavian journal of infectious diseases, Volume: 9, Issue: 4	1977
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Article	Year
Development and validation of a dosing nomogram for continuous infusion cloxacillin in infective endocarditis. The Journal of antimicrobial chemotherapy, 04-03, Volume: 78, Issue: 4	2023
Pharmacokinetic-Pharmacodynamic Study of Ampicillin-Cloxacillin Combination in Indian Thoroughbred Horses (Equus caballus) and Safety Evaluation of the Computed Dosage Regimen. Journal of equine veterinary science, Volume: 115	2022
Effectiveness of vancomycin plus cloxacillin compared with vancomycin, cloxacillin and daptomycin single therapies in the treatment of methicillin-resistant and methicillin-susceptible Staphylococcus aureus in a rabbit model of experimental endocarditis. The Journal of antimicrobial chemotherapy, 05-12, Volume: 76, Issue: 6	2021
Should we reconsider cefazolin for treating staphylococcal meningitis? A retrospective analysis of cefazolin and cloxacillin cerebrospinal fluid levels in patients treated for staphylococcal meningitis. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, Volume: 26, Issue: 10	2020
Circular dichroism spectroscopy: An efficient approach for the quantitation of ampicillin in presence of cloxacillin. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, May-05, Volume: 160	2016
Saliva versus plasma pharmacokinetics: theory and application of a salivary excretion classification system. Molecular pharmaceutics, Aug-06, Volume: 9, Issue: 8	2012
Efficacy of daptomycin-cloxacillin combination in experimental foreign-body infection due to methicillin-resistant Staphylococcus aureus. Antimicrobial agents and chemotherapy, Volume: 56, Issue: 7	2012
Role of intravenous cloxacillin for inpatient infections. Medecine et maladies infectieuses, Volume: 42, Issue: 6	2012
Assessment of interindividual variability of plasma concentrations after administrazion of high doses of intravenous amoxicillin or cloxacillin in critically ill patients. Journal of chemotherapy (Florence, Italy), Volume: 23, Issue: 5	2011
Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics. Antimicrobial agents and chemotherapy, Volume: 52, Issue: 8	2008
Validation of a simplified netilmicin dosage regimen in infants. Scandinavian journal of infectious diseases, Volume: 36, Issue: 6-7	2004
Comparison of ex-vivo serum bactericidal activity of cefepime, ceftazidime and cloxacillin against Staphylococcus aureus. Diagnostic microbiology and infectious disease, Volume: 33, Issue: 1	1999
Drug disposition in cystic fibrosis. Clinical pharmacokinetics, Volume: 35, Issue: 4	1998
Right-sided endocarditis caused by Staphylococcus aureus in drug abusers. Antimicrobial agents and chemotherapy, Volume: 39, Issue: 2	1995
Investigations on the flucloxacillin levels in human serum, lung tissue, pericardial fluid and heart tissue. International journal of clinical pharmacology, therapy, and toxicology, Volume: 18, Issue: 9	1980
The metabolic disposition of flucloxacillin in patients with impaired kidney function. European journal of clinical pharmacology, Volume: 22, Issue: 5	1982
Assessment of chemoprophylaxis in open-heart surgery patients. International journal of clinical pharmacology, therapy, and toxicology, Volume: 20, Issue: 7	1982
Staphylococcal endocarditis in rabbits treated with a low dose of cloxacillin. Antimicrobial agents and chemotherapy, Volume: 25, Issue: 3	1984
Comparison of human serum, parotid and mixed saliva levels of phenoxymethylpenicillin, ampicillin, cloxacillin and cephalexin. British journal of pharmacology, Volume: 43, Issue: 1	1971
Pacemaker infections. A clinical study with special reference to prophylactic use of some isoxazolyl penicillins. Acta medica Scandinavica. Supplementum, Volume: 699	1985
Flucloxacillin concentration in serum and wound exudate during open heart surgery. The Journal of antimicrobial chemotherapy, Volume: 16, Issue: 2	1985
Antibiotic-associated gastrointestinal symptoms in general pediatric outpatients. Pediatrics, Volume: 76, Issue: 3	1985
Flucloxacillin in chronic leg ulcers. Penetration of flucloxacillin into chronic leg ulcer exudate and the effect on the bacteria. Acta pathologica, microbiologica, et immunologica Scandinavica. Section B, Microbiology, Volume: 95, Issue: 4	1987
Treatment of Staphylococcus aureus endocarditis in rats with coumermycin A1 and ciprofloxacin, alone or in combination. Antimicrobial agents and chemotherapy, Volume: 31, Issue: 4	1987
Oral antimicrobial therapy for adults with osteomyelitis or septic arthritis. The Journal of infectious diseases, Volume: 155, Issue: 5	1987
Acute staphylococcal septic arthritis: the effect of cloxacillin therapy in an avian model. Journal of orthopaedic research : official publication of the Orthopaedic Research Society, Volume: 6, Issue: 1	1988
Effect of ingesta on systemic availability of penicillins administered orally in dogs. Journal of veterinary pharmacology and therapeutics, Volume: 9, Issue: 2	1986
19F NMR spectroscopy study of the metabolites of flucloxacillin in rat urine. The Journal of pharmacy and pharmacology, Volume: 37, Issue: 12	1985
Pharmacokinetic analysis of cloxacillin loss in children undergoing major surgery with massive bleeding. Antimicrobial agents and chemotherapy, Volume: 34, Issue: 6	1990
Ocular and serum disposition kinetics of cloxacillin after topical administration of benzathine cloxacillin and intravenous administration of sodium cloxacillin to calves. American journal of veterinary research, Volume: 51, Issue: 3	1990
Role of tolerance in cloxacillin prophylaxis of experimental Staphylococcus aureus endocarditis. The Journal of infectious diseases, Volume: 166, Issue: 1	1992
[Pharmacokinetics and clinical effects of cefdinir 10% fine granules in pediatrics]. The Japanese journal of antibiotics, Volume: 45, Issue: 1	1992
Pharmacokinetic aspects of streptomycin treatment of neonatal septicemia. Scandinavian journal of infectious diseases, Volume: 9, Issue: 4	1977
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Article	Year
Cloxacillin or fosfomycin plus daptomycin combinations are more active than cloxacillin monotherapy or combined with gentamicin against MSSA in a rabbit model of experimental endocarditis. The Journal of antimicrobial chemotherapy, 12-01, Volume: 75, Issue: 12	2020
The use of an internal teat sealant in combination with cloxacillin dry cow therapy for the prevention of clinical and subclinical mastitis in seasonal calving dairy cows. Journal of dairy science, Volume: 93, Issue: 10	2010
Large-volume sample stacking combined with separation by 2-hydroxypropyl-beta-cyclodextrin for analysis of isoxyzolylpenicillins by capillary electrophoresis. Electrophoresis, Volume: 24, Issue: 17	2003
Displacement of bilirubin from cord serum by sulphadimethoxine, amoxycillin, clavulanic acid in combination with either amoxycillin or ticarcillin, temocillin and cloxacillin. British journal of clinical pharmacology, Volume: 20, Issue: 4	1985
Imipenem/cilastatin as monotherapy in severe infections: comparison with cefotaxime in combination with metronidazole and cloxacillin. Report from a Norwegian Study Group. Scandinavian journal of infectious diseases, Volume: 19, Issue: 6	1987
A randomised comparison of ceftazidime and piperacillin, both in combination with flucloxacillin for treatment of febrile episodes in neutropenic children. Finnish Three-Centre Study. Scandinavian journal of infectious diseases, Volume: 22, Issue: 2	1990
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

cloxacillin

Description

Cross-References

Synonyms (109)

Effects

Actions

Treatment

Roles (2)

Drug Classes (3)

Protein Targets (13)

Inhibition Measurements

Other Measurements

Biological Processes (36)

Molecular Functions (13)

Ceullar Components (14)

Bioassays (371)

Research

Studies (1,604)

Study Types

Clinical Trials (18)

Trial Overview

Trial Outcomes

Clinical Response (Cure, Failure, or Indeterminate) as Determined by the Investigator Based the Presence or Absence of Clinical Signs and Symptoms Associated With Bacteremia, Metastatic Complications, or Positive Culture at the Test of Cure Evaluation

Cure Rate

Number of Participants That Changed From Vancomycin to Another Study Antibiotic Due to an Adverse Event

Number of Participants With Adverse Events Leading to Study Drug Withdrawal

Number of Participants With Serious Adverse Events

Antibiotic Days by Treatment Group

Pharmacokinetics (PK): Area Under the Plasma Concentration-Time Curve for Daptomycin From 0 to the Last Sampling Time Point (AUC[0-t])

Percentage of Participants With an Overall Therapeutic Response at Test of Cure Visit

Percentage of Participants With Treatment-Emergent Adverse Events (TEAEs)

Duration of Treatment (Intravenous)

Duration of Treatment (Intravenous and Oral)

Number of Participants With Microbiological Response at Test-of-Cure (TOC) Visit

Number of Patients With Adverse Events, Serious Adverse Events and Death

Number of Patients With Clinical Success at the Test-Of-Cure (TOC) Visit

Number of Participants With Treatment-emergent Creatine Phosphokinase (CPK) Elevations Through End of Therapy/Early Termination (EOT/ET)

Overall Therapeutic Outcome at Test of Cure (TOC)/Safety Visit

Investigator Clinical Response (Success or Failure) at EOT in the Microbiological All-treated (mAT) Population

Number of Participants With a Clinical Outcome of Cure at Test of Cure (TOC)

Number of Participants With an Investigator Clinical Outcome of Cure at TOC in the Microbiological All-treated (mAT) Population

Number of Participants With the Development of a New Metastatic Foci of S. Aureus Infection at Test of Cure (TOC) in the Microbiological All-treated (mAT) Populations

Related Drugs (2,110)

Related Conditions (2,432)

Research Highlights

Safety/Toxicity (6)

Pharmacokinetics (20)

Bioavailability (21)

Dosage (37)

Interactions (6)