Aldo-keto reductase family 1 member C2

An aldo-keto reductase family 1 member C2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P52895]

Synonyms

EC 1.-.-.-;
EC 1.1.1.112;
EC 1.1.1.209;
EC 1.1.1.53;
EC 1.1.1.62;
EC 1.3.1.20;
3-alpha-HSD3;
Chlordecone reductase homolog HAKRD;
Dihydrodiol dehydrogenase 2;
DD-2;
DD2;
Dihydrodiol dehydrogenase/bile acid-bind

Research

Bioassay Publications (20)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (10.00)	29.6817
2010's	17 (85.00)	24.3611
2020's	1 (5.00)	2.80

Compounds (21)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
berberine	Homo sapiens (human)	IC50	6.7100	1	1
flufenamic acid	Homo sapiens (human)	IC50	1.3467	6	6
flurbiprofen	Homo sapiens (human)	IC50	32.5000	1	1
gliclazide	Homo sapiens (human)	IC50	1,000.0000	1	1
glimepiride	Homo sapiens (human)	IC50	50.0000	1	1
indomethacin	Homo sapiens (human)	IC50	54.1000	5	5
meclofenamic acid	Homo sapiens (human)	IC50	8.7400	2	2
mefenamic acid	Homo sapiens (human)	IC50	6.9700	1	1
mefenamic acid	Homo sapiens (human)	Ki	0.2200	1	1
fenamic acid	Homo sapiens (human)	IC50	0.4400	2	2
medroxyprogesterone acetate	Homo sapiens (human)	IC50	4.0405	2	2
3,5-dichlorosalicylic acid	Homo sapiens (human)	Ki	12.1429	3	10
3,5-dibromosalicylic acid	Homo sapiens (human)	Ki	0.0820	1	1
6-methoxy-2-naphthylacetic acid	Homo sapiens (human)	IC50	19.0400	1	1
dexibuprofen	Homo sapiens (human)	IC50	42.4000	1	1
octyl gallate	Homo sapiens (human)	IC50	9.2800	1	1
5-methoxy-methylindoleacetic acid	Homo sapiens (human)	IC50	100.0000	1	1
naproxen	Homo sapiens (human)	IC50	16.2800	2	2
jasmonic acid	Homo sapiens (human)	Ki	18.0000	1	1
caffeic acid phenethyl ester	Homo sapiens (human)	IC50	15.8800	2	2
drupanin	Homo sapiens (human)	IC50	113.6310	3	3

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
n-(3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl)-3-(2-((((1,1-dimethylethyl)amino)carbonyl)amino)-3,3-dimethyl-1-oxobutyl)-6,6-dimethyl-3-azabicyclo(3.1.0)hexan-2-carboxamide	Homo sapiens (human)	Km	52.2600	1	1

Enables

This protein enables 11 target(s):

Target	Category	Definition
aldose reductase (NADPH) activity	molecular function	Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+. [EC:1.1.1.21]
estradiol 17-beta-dehydrogenase [NAD(P)] activity	molecular function	Catalysis of the reaction: estradiol-17-beta + NAD(P)+ = estrone + NAD(P)H + H+. The activity can use NAD+ or NADP+ as the acceptor. [EC:1.1.1.62]
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	molecular function	Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule. [GOC:ai]
phenanthrene 9,10-monooxygenase activity	molecular function	Catalysis of the reaction: phenanthrene + O2 + NADH + H+ = H2O + NAD+ + phenanthrene-9,10-oxide. [UM-BBD_reactionID:r0495]
carboxylic acid binding	molecular function	Binding to a carboxylic acid, an organic acid containing one or more carboxyl (COOH) groups or anions (COO-). [GOC:mah, ISBN:0198506732]
bile acid binding	molecular function	Binding to a bile acid, a steroid carboxylic acids occurring in bile. [GOC:rph]
androstan-3-alpha,17-beta-diol dehydrogenase activity	molecular function	Catalysis of the reaction: NAD+ + androstan-3-alpha,17-beta-diol = 17-beta-hydroxyandrostan-3-one + NADH + H+. [EC:1.1.1.53, MetaCyc:1.1.1.53-RXN]
ketosteroid monooxygenase activity	molecular function	Catalysis of the reaction: O2 + NADPH + progesterone = H2O + NADP+ + testosterone acetate. [EC:1.14.13.54, MetaCyc:1.14.13.54-RXN]
trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity	molecular function	Catalysis of the reaction: NADP+ + trans-1,2-dihydrobenzene-1,2-diol = NADPH + catechol. [EC:1.3.1.20, MetaCyc:1.3.1.20-RXN]
indanol dehydrogenase activity	molecular function	Catalysis of the reaction: indan-1-ol + NAD(P)+ = indanone + NAD(P)H + H+. [EC:1.1.1.112, MetaCyc:INDANOL-DEHYDROGENASE-RXN]
androsterone dehydrogenase activity	molecular function	Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione. [EC:1.1.1.209, MetaCyc:1.1.1.209-RXN]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

Involved In

This protein is involved in 12 target(s):

Target	Category	Definition
prostaglandin metabolic process	biological process	The chemical reactions and pathways involving prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities. [ISBN:0198506732]
G protein-coupled receptor signaling pathway	biological process	The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]
digestion	biological process	The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. [GOC:isa_complete, ISBN:0198506732]
steroid metabolic process	biological process	The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. [ISBN:0198547684]
positive regulation of cell population proliferation	biological process	Any process that activates or increases the rate or extent of cell proliferation. [GOC:go_curators]
epithelial cell differentiation	biological process	The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium. [GOC:ecd, PMID:11839751]
progesterone metabolic process	biological process	The chemical reactions and pathways involving progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants. [GOC:jl, http://www.cogsci.princeton.edu/]
daunorubicin metabolic process	biological process	The chemical reactions and pathways involving daunorubicin, a chemotherapeutic of the anthracycline family that is given as a treatment for some types of cancer. [PMID:20837989]
doxorubicin metabolic process	biological process	The chemical reactions and pathways involving doxorubicin, an anthracycline antibiotic, used in cancer chemotherapy. [PMID:10200167]
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	biological process	Any process that activates or increases the frequency, rate or extent of phosphatidylinositol 3-kinase/protein kinase B signal transduction. [GOC:ai]
cellular response to jasmonic acid stimulus	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus. [GOC:mah]
cellular response to prostaglandin D stimulus	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin D stimulus. [GOC:sl]

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