Solute carrier family 28 member 3

A solute carrier family 28 member 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9HAS3]

Synonyms

Concentrative Na(+)-nucleoside cotransporter 3;
CNT 3;
hCNT3

Research

Bioassay Publications (2)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (50.00)	29.6817
2010's	1 (50.00)	24.3611
2020's	0 (0.00)	2.80

Compounds (10)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
phloretin	Homo sapiens (human)	Ki	32.2800	1	1
uridine	Homo sapiens (human)	IC50	5.4000	1	1
uridine	Homo sapiens (human)	Ki	3.4000	1	1
phlorhizin	Homo sapiens (human)	Ki	16.0000	1	1
resacetophenone	Homo sapiens (human)	Ki	100.0000	1	1
adenosine	Homo sapiens (human)	IC50	3.3000	1	1
adenosine	Homo sapiens (human)	Ki	2.1000	1	1
4-nitrobenzylthioinosine	Homo sapiens (human)	Ki	88.0500	1	1
2,4,6-trihydroxyacetophenone	Homo sapiens (human)	Ki	100.0000	1	1
2,6-dihydroxyacetophenone	Homo sapiens (human)	Ki	100.0000	1	1
tecadenoson	Homo sapiens (human)	IC50	200.0000	1	1
tecadenoson	Homo sapiens (human)	Ki	126.0000	1	1
trilobatin	Homo sapiens (human)	Ki	100.0000	1	1

Enables

This protein enables 6 target(s):

Target	Category	Definition
purine nucleobase transmembrane transporter activity	molecular function	Enables the transfer of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, from one side of a membrane to the other. [ISBN:0198506732]
nucleoside:sodium symporter activity	molecular function	Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nucleoside(out) + Na+(out) = nucleoside(in) + Na+(in). [GOC:ai]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
uridine transmembrane transporter activity	molecular function	Enables the transfer of uridine, uracil riboside, from one side of a membrane to the other. [GOC:go_curators]
purine-specific nucleoside:sodium symporter activity	molecular function	Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: purine(out) + Na+(out) = nucleoside(in) + Na+(in). [TC:2.A.41.2.1]
pyrimidine- and adenosine-specific:sodium symporter activity	molecular function	Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: (pyrimidine nucleoside or adenosine)(out) + Na+(out) = (pyrimidine nucleoside or adenosine)(in) + Na+(in). [TC:2.A.41.2.3]

Located In

This protein is located in 3 target(s):

Target	Category	Definition
endoplasmic reticulum membrane	cellular component	The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
brush border membrane	cellular component	The portion of the plasma membrane surrounding the brush border. [GOC:mah]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Involved In

This protein is involved in 10 target(s):

Target	Category	Definition
xenobiotic metabolic process	biological process	The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:cab2, GOC:krc]
xenobiotic transmembrane transport	biological process	The process in which a xenobiotic, a compound foreign to the organim exposed to it, is transported across a membrane. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:ai, GOC:bf, GOC:krc]
pyrimidine nucleobase transport	biological process	The directed movement of pyrimidine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]
uridine transmembrane transport	biological process	The directed movement of uridine, uracil riboside, across a lipid bilayer, by means of some agent such as a transporter or pore. [GOC:go_curators]
sodium ion transmembrane transport	biological process	A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:vw]
pyrimidine-containing compound transmembrane transport	biological process	The process in which a pyrimidine-containing compound is transported across a membrane. A pyrimidine-containing compound is any compound that contains pyrimidine or a formal derivative thereof. [GOC:mah]
nucleoside transmembrane transport	biological process	The directed movement of nucleoside across a membrane. [GOC:pr, GOC:TermGenie]
purine nucleobase transmembrane transport	biological process	The process in which a purine nucleobase is transported across a membrane. [GO_REF:0000069, GOC:TermGenie]
pyrimidine nucleoside transport	biological process	The directed movement of a pyrimidine nucleoside, a pyrimidine base covalently bonded to a ribose or deoxyribose sugar, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]
purine nucleoside transmembrane transport	biological process	The process in which a purine nucleoside is transported across a membrane. A purine nucleoside is a purine base covalently bonded to a ribose or deoxyribose sugar. [GOC:ai, GOC:vw]