Page last updated: 2024-08-07 15:43:30
Trypsin-1
A serine protease 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P07477]
Synonyms
EC 3.4.21.4;
Beta-trypsin;
Cationic trypsinogen;
Serine protease 1;
Trypsin I
Research
Bioassay Publications (56)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (1.79) | 18.7374 |
| 1990's | 12 (21.43) | 18.2507 |
| 2000's | 26 (46.43) | 29.6817 |
| 2010's | 16 (28.57) | 24.3611 |
| 2020's | 1 (1.79) | 2.80 |
Compounds (54)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| 5-(n,n-hexamethylene)amiloride | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| bis(5-amidino-2-benzimidazolyl)methane | Homo sapiens (human) | IC50 | 4.4000 | 1 | 1 |
| bis(5-amidino-2-benzimidazolyl)methane | Homo sapiens (human) | Ki | 206.0149 | 3 | 14 |
| camostat | Homo sapiens (human) | IC50 | 0.0035 | 1 | 1 |
| n(alpha)-(2-naphthylsulfonylglycyl)-4-amidinophenylalanine piperidide | Homo sapiens (human) | IC50 | 0.1690 | 1 | 1 |
| nafamostat | Homo sapiens (human) | IC50 | 0.0170 | 1 | 1 |
| netropsin | Homo sapiens (human) | IC50 | 35.0000 | 1 | 2 |
| pentamidine | Homo sapiens (human) | IC50 | 43.3333 | 1 | 3 |
| sulfaguanidine | Homo sapiens (human) | Ki | 1.3500 | 1 | 1 |
| benzylamine | Homo sapiens (human) | Ki | 299,916.0000 | 1 | 1 |
| isoquinoline-1,3,4-trione | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| amiloride | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| 2'-carbomethoxyphenyl 4-guanidinobenzoate | Homo sapiens (human) | IC50 | 0.0650 | 1 | 1 |
| baicalin | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| 4-aminomethylbenzoic acid | Homo sapiens (human) | Ki | 500,035.0000 | 1 | 1 |
| 4-methylbenzylamine | Homo sapiens (human) | Ki | 666,807.0000 | 1 | 1 |
| leupeptin | Homo sapiens (human) | IC50 | 0.6000 | 1 | 1 |
| 4-methoxybenzylamine | Homo sapiens (human) | Ki | 1,000,000.0000 | 1 | 1 |
| p-Aminobenzamidine dihydrochloride | Homo sapiens (human) | Ki | 8.9000 | 1 | 1 |
| mci 9038 | Homo sapiens (human) | Ki | 1.9900 | 1 | 1 |
| sivelestat | Homo sapiens (human) | IC50 | 2.0000 | 1 | 1 |
| sepimostate mesilate | Homo sapiens (human) | Ki | 0.2900 | 1 | 1 |
| dx 9065 | Homo sapiens (human) | IC50 | 3.2000 | 1 | 1 |
| dx 9065 | Homo sapiens (human) | Ki | 0.6200 | 3 | 3 |
| efegatran | Homo sapiens (human) | IC50 | 0.0080 | 1 | 1 |
| acetylphenylalanyl-prolyl-boroarginine | Homo sapiens (human) | Ki | 0.0045 | 2 | 2 |
| skullcapflavone ii | Homo sapiens (human) | IC50 | 110.0000 | 1 | 1 |
| foy 251 | Homo sapiens (human) | IC50 | 0.0550 | 1 | 1 |
| melagatran | Homo sapiens (human) | IC50 | 0.0119 | 1 | 2 |
| melagatran | Homo sapiens (human) | Ki | 0.0043 | 1 | 1 |
| beta-naphthamidine | Homo sapiens (human) | Ki | 7.7900 | 2 | 2 |
| razaxaban | Homo sapiens (human) | Ki | 6.9714 | 7 | 7 |
| dabigatran | Homo sapiens (human) | Ki | 0.0502 | 2 | 2 |
| benzamidine | Homo sapiens (human) | Ki | 237.5000 | 1 | 2 |
| 1-(2-Naphthylmethyl)-2,3-dioxo-indoline-5-carboxamide | Homo sapiens (human) | IC50 | 352.0000 | 1 | 1 |
| telaprevir | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| wogonoside | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| silybin | Homo sapiens (human) | IC50 | 3.7000 | 1 | 1 |
| ganhuangenin | Homo sapiens (human) | IC50 | 88.0000 | 1 | 1 |
| quercetin | Homo sapiens (human) | IC50 | 15.4000 | 1 | 1 |
| baicalein | Homo sapiens (human) | IC50 | 3.7000 | 1 | 1 |
| wogonin | Homo sapiens (human) | IC50 | 105.0000 | 1 | 1 |
| camostat mesylate | Homo sapiens (human) | IC50 | 0.0506 | 1 | 1 |
| 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one | Homo sapiens (human) | IC50 | 61.0000 | 1 | 1 |
| otamixaban | Homo sapiens (human) | Ki | 0.3010 | 1 | 2 |
| bms 740808 | Homo sapiens (human) | Ki | 2.8000 | 2 | 2 |
| bms-262084 | Homo sapiens (human) | IC50 | 0.0272 | 2 | 2 |
| dpc 423 | Homo sapiens (human) | Ki | 0.0600 | 3 | 3 |
| zd 8321 | Homo sapiens (human) | Ki | 66.6000 | 1 | 1 |
| gw 813893 | Homo sapiens (human) | IC50 | 158.0000 | 1 | 1 |
| l 374087 | Homo sapiens (human) | Ki | 3.2000 | 5 | 5 |
| darexaban | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| lb 30057 | Homo sapiens (human) | Ki | 3.2900 | 1 | 1 |
| darexaban glucuronide | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| apixaban | Homo sapiens (human) | Ki | 4.2000 | 1 | 1 |
| mk-7009 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| rpx7009 | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
Enables
This protein enables 2 target(s):
| Target | Category | Definition |
|---|---|---|
| serine-type endopeptidase activity | molecular function | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE] |
| metal ion binding | molecular function | Binding to a metal ion. [GOC:ai] |
Located In
This protein is located in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| extracellular region | cellular component | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators] |
| collagen-containing extracellular matrix | cellular component | An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells. [GOC:BHF, GOC:rph, PMID:21123617] |
| blood microparticle | cellular component | A phospholipid microvesicle that is derived from any of several cell types, such as platelets, blood cells, endothelial cells, or others, and contains membrane receptors as well as other proteins characteristic of the parental cell. Microparticles are heterogeneous in size, and are characterized as microvesicles free of nucleic acids. [GOC:BHF, GOC:mah, PMID:16373184] |
Active In
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| extracellular space | cellular component | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684] |
Involved In
This protein is involved in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| digestion | biological process | The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. [GOC:isa_complete, ISBN:0198506732] |
| extracellular matrix disassembly | biological process | A process that results in the breakdown of the extracellular matrix. [GOC:jid] |
| proteolysis | biological process | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. [GOC:bf, GOC:mah] |