Page last updated: 2024-12-09
stattic
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 2779853 |
| CHEMBL ID | 1337170 |
| CHEBI ID | 86989 |
| SCHEMBL ID | 1156180 |
| MeSH ID | M0507007 |
Synonyms (57)
| Synonym |
|---|
| stat3 inhibitor v, stattic |
| 6-nitrobenzo[b]thiophene-1,1-dioxide |
| MAYBRIDGE1_005148 |
| NCGC00167848-01 |
| NCGC00167848-02 |
| AKOS000276641 |
| 6-nitro-1-benzothiophene 1,1-dioxide |
| HMS556B22 |
| EC-000.2451 |
| NCGC00167848-03 |
| HMS3263A18 |
| stattic , |
| 6-nitrobenzo[b]thiophene 1,1-dioxide |
| 19983-44-9 |
| 6-nitro-1lambda6-benzothiophene-1,1-dione |
| EN300-49874 |
| chebi:86989 , |
| 6-nitro-1 |
| bdbm50396169 |
| chembl1337170 , |
| FT-0621264 |
| LP01048 |
| PB27460 |
| S7024 |
| ZRRGOUHITGRLBA-UHFFFAOYSA-N |
| CCG-222352 |
| 1,1-dioxide-6-nitro-benzo[b]thiophene |
| SCHEMBL1156180 |
| AKOS025243444 |
| tox21_501048 |
| NCGC00261733-01 |
| HY-13818 |
| CS-5879 |
| PS-4432 |
| benzo[b]thiophene, 6-nitro-, 1,1-dioxide |
| c8h5no4s |
| methyl7-benzyloxy-1h-indazole-3-carboxylate |
| AC-35411 |
| HB1437 |
| 6-nitro-1h-1-benzothiophene-1,1-dione |
| stat3 inhibitor v |
| DTXSID70381575 |
| mfcd00173799 |
| 6-nitro-1h-benzo[b]thiophene-1,1-dione |
| HMS3652H16 |
| stattic, >=98% (hplc), powder |
| J-012915 |
| SW219435-1 |
| A920440 |
| Q27159314 |
| EX-A1455 |
| BCP13194 |
| SDCCGSBI-0633784.P001 |
| NCGC00167848-10 |
| AMY4954 |
| Z595059248 |
| SY122169 |
Research Excerpts
Overview
Stattic is an inhibitor of STAT3, which is found constitutively active in many cancers. Stattic demonstrates that the SH2 domain is not a dead target.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Stattic is an inhibitor of STAT3, which is found constitutively active in many cancers and plays a major role in cancer progression." | ( STAT3 inhibitory stattic enhances immunogenic cell death induced by chemotherapy in cancer cells. Hejazi, MS; Jafari, S; Lavasanifar, A; Maleki-Dizaji, N; Mesgari, M; Molavi, O, 2020) | 1.62 |
| "Stattic is a new tool for studying Stat3 signaling and demonstrates that the SH2 domain is not a dead target." | ( A new small-molecule Stat3 inhibitor. McMurray, JS, 2006) | 1.06 |
Treatment
Stattic treatment can mitigate the TGF-β1-triggered inflammatory response, myofibroblast activation, oxidative stress, and hyperproliferation by modulating the JAK1/STAT3 pathway. Stattic-treated mice exhibited delayed onset of proteinuria (3 weeks later than controls)
| Excerpt | Reference | Relevance |
|---|---|---|
| "Stattic treatment can mitigate the TGF-β1-triggered inflammatory response, myofibroblast activation, oxidative stress, and hyperproliferation by modulating the JAK1/STAT3 pathway." | ( Stattic alleviates pulmonary fibrosis in a mouse model of rheumatoid arthritis-relevant interstitial lung disease. Li, Y; Long, X; Luo, C; Tang, W; Xie, L; Zhang, Q, 2023) | 3.07 |
| "Stattic treatment had potential beneficial effects against sepsis-induced cardiac inflammation, dysfunction and damage. " | ( Stattic ameliorates the cecal ligation and puncture-induced cardiac injury in septic mice via IL-6-gp130-STAT3 signaling pathway. Hattori, Y; Imbaby, S, 2023) | 3.8 |
| "Stattic-treated mice exhibited delayed onset of proteinuria (3 weeks later than controls), and had lower levels of anti-dsDNA antibodies and inflammatory cytokines." | ( Signal transducer and activator of transcription (STAT) 3 inhibition delays the onset of lupus nephritis in MRL/lpr mice. Edwards, LJ; Kyttaris, V; Mizui, M, 2015) | 1.14 |
| "Treated with Stattic for 0, 1, 3, 6, 12, 24 hours, IL-8 mRNA was significantly up-regulated, and after 6 hours, the expression of IL-8 protein and apoptosis of THP-1 cells were up-regulated in a time-dependent manner." | ( [STAT3 inhibitor Stattic induced IL-8 production and cell apotosis in THP-1 cells by activating ERK pathway]. Chen, M; Chen, X; Xiao, Z; Yang, M, 2019) | 1.21 |
| "Treatment with stattic at a dose sufficient to inhibit STAT3 reversed MOR expression in STZ rats." | ( Signals for increase of μ-opioid receptor expression in muscle by hyperglycemia. Chen, LJ; Cheng, JT; Lin, KC; Niu, HS; Yang, TT; Yeh, MC, 2014) | 0.74 |
| "Treatment with STATTIC did reduce hepatic neutrophil accumulation." | ( STAT3 does not regulate acute liver injury after ischemia/reperfusion. Clarke, C; Edwards, MJ; Lentsch, AB; Sakai, N; Schuster, R; Tevar, AD, 2011) | 0.71 |
Toxicity
| Excerpt | Reference | Relevance |
|---|---|---|
| "Hand-foot skin reaction is a most common multi-kinase inhibitor-related adverse event." | ( Association of toxicity of sorafenib and sunitinib for human keratinocytes with inhibition of signal transduction and activator of transcription 3 (STAT3). Bito, T; Hirai, M; Hirano, T; Kume, M; Makimoto, H; Mizumoto, A; Mukai, A; Nakagawa, T; Nishigori, C; Nishimura, K; Uda, A; Yamamoto, K; Yamashita, K, 2014) | 0.4 |
Bioavailability
| Excerpt | Reference | Relevance |
|---|---|---|
| "In a continuing effort to develop orally bioavailable small-molecule STAT3 inhibitors as potential therapeutic agents for human cancer, a series of novel diversified analogues based on our identified lead compound HJC0149 (1) (5-chloro-N-(1,1-dioxo-1H-1λ(6)-benzo[b]thiophen-6-yl)-2-hydroxybenzamide, Eur." | ( Discovery of potent anticancer agent HJC0416, an orally bioavailable small molecule inhibitor of signal transducer and activator of transcription 3 (STAT3). Cai, G; Chen, H; Ding, C; Ding, Y; Flores, RM; Shen, Q; Wang, L; Wild, C; Xiong, A; Yang, Z; Ye, N; Zhou, J, 2014) | 0.4 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Roles (3)
| Role | Description |
|---|---|
| antineoplastic agent | A substance that inhibits or prevents the proliferation of neoplasms. |
| STAT3 inhibitor | An inhibitor of signal transducer and activator of transcription 3 (STAT3) |
| radiosensitizing agent | A drug that makes increases the sensitivity of tumour cells to radiation therapy. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
Drug Classes (3)
| Class | Description |
|---|---|
| 1-benzothiophenes | |
| C-nitro compound | A nitro compound having the nitro group (-NO2) attached to a carbon atom. |
| sulfone | An organosulfur compound having the structure RS(=O)2R (R =/= H). |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
Protein Targets (31)
Potency Measurements
| Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 15.8489 | 0.0032 | 45.4673 | 12,589.2998 | AID2517 |
| Nrf2 | Homo sapiens (human) | Potency | 2.9093 | 0.0920 | 8.2222 | 23.1093 | AID624149 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 1.5799 | 0.1000 | 20.8793 | 79.4328 | AID488773; AID588453; AID588456 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 31.6228 | 0.1413 | 37.9142 | 100.0000 | AID1490 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 20.5878 | 0.0041 | 10.8903 | 31.5287 | AID493107 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 3.5481 | 0.0030 | 8.7949 | 48.0869 | AID1347053 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 50.1187 | 0.0316 | 37.5844 | 354.8130 | AID504865 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 21.1923 | 0.5318 | 15.4358 | 37.6858 | AID504845 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 19.6743 | 0.0015 | 30.6073 | 15,848.9004 | AID1224819; AID1224820; AID1224821; AID1224823 |
| polyprotein | Zika virus | Potency | 3.5481 | 0.0030 | 8.7949 | 48.0869 | AID1347053 |
| Parkin | Homo sapiens (human) | Potency | 23.1093 | 0.8199 | 14.8306 | 44.6684 | AID720573 |
| arylsulfatase A | Homo sapiens (human) | Potency | 0.0601 | 1.0691 | 13.9551 | 37.9330 | AID720538 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 26.6795 | 0.0355 | 20.9770 | 89.1251 | AID504332 |
| heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | Homo sapiens (human) | Potency | 4.1400 | 0.0165 | 25.3078 | 41.3999 | AID602332 |
| NPC intracellular cholesterol transporter 1 precursor | Homo sapiens (human) | Potency | 91.9997 | 0.0126 | 2.4518 | 25.0177 | AID485313 |
| atrial natriuretic peptide receptor 1 precursor | Homo sapiens (human) | Potency | 10.6910 | 0.1346 | 10.3950 | 30.1313 | AID1347049 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 18.8239 | 0.3548 | 28.0659 | 89.1251 | AID504847; AID602199; AID602200; AID602201; AID602202 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 17.7828 | 0.0060 | 26.1688 | 89.1251 | AID488953 |
| atrial natriuretic peptide receptor 2 precursor | Homo sapiens (human) | Potency | 5.8479 | 0.0066 | 9.8094 | 18.4927 | AID1347050 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 58.0479 | 0.0002 | 2.6215 | 31.4954 | AID485297 |
| serine/threonine-protein kinase mTOR isoform 1 | Homo sapiens (human) | Potency | 1.5535 | 0.0037 | 8.6189 | 23.2809 | AID2660; AID2667; AID2668 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 10.2918 | 0.0079 | 8.2332 | 1,122.0200 | AID2546; AID2551 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 28.1838 | 0.2512 | 15.8432 | 39.8107 | AID504327 |
| Alpha-synuclein | Homo sapiens (human) | Potency | 20.5962 | 0.5623 | 9.3985 | 25.1189 | AID652106 |
| D(1A) dopamine receptor | Sus scrofa (pig) | Potency | 1.8493 | 0.0037 | 8.1081 | 23.2809 | AID2667 |
| Ataxin-2 | Homo sapiens (human) | Potency | 6.3096 | 0.0119 | 12.2221 | 68.7989 | AID588378 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 4.7755 | 0.0601 | 10.7453 | 37.9330 | AID485368 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
Inhibition Measurements
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Signal transducer and activator of transcription 3 | Homo sapiens (human) | IC50 (µMol) | 5.1000 | 0.0230 | 4.1378 | 9.9800 | AID1362928; AID1909687; AID702274 |
| Hypoxia-inducible factor 1-alpha | Homo sapiens (human) | IC50 (µMol) | 0.0430 | 0.0007 | 2.4652 | 9.2100 | AID1639059 |
| Thioredoxin glutathione reductase | Schistosoma mansoni | IC50 (µMol) | 2.0100 | 2.0100 | 5.0975 | 7.0800 | AID1752860 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
Activation Measurements
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Signal transducer and activator of transcription 3 | Homo sapiens (human) | Kd | 1.5280 | 0.5000 | 2.1993 | 4.5700 | AID1757423 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
Biological Processes (285)
Molecular Functions (70)
Ceullar Components (66)
Bioassays (93)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1508630 | Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay | 2021 | Cell reports, 04-27, Volume: 35, Issue:4 | A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
| AID1347154 | Primary screen GU AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID588349 | qHTS for Inhibitors of ATXN expression: Validation of Cytotoxic Assay | |||
| AID1347083 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347058 | CD47-SIRPalpha protein protein interaction - HTRF assay qHTS validation | 2019 | PloS one, , Volume: 14, Issue:7 | Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors. |
| AID1347414 | qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: Secondary screen by immunofluorescence | 2020 | ACS chemical biology, 07-17, Volume: 15, Issue:7 | High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle. |
| AID1347057 | CD47-SIRPalpha protein protein interaction - LANCE assay qHTS validation | 2019 | PloS one, , Volume: 14, Issue:7 | Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors. |
| AID1347059 | CD47-SIRPalpha protein protein interaction - Alpha assay qHTS validation | 2019 | PloS one, , Volume: 14, Issue:7 | Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors. |
| AID1347151 | Optimization of GU AMC qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347049 | Natriuretic polypeptide receptor (hNpr1) antagonism - Pilot screen | 2019 | Science translational medicine, 07-10, Volume: 11, Issue:500 | Inhibition of natriuretic peptide receptor 1 reduces itch in mice. |
| AID1347412 | qHTS assay to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: Counter screen cell viability and HiBit confirmation | 2020 | ACS chemical biology, 07-17, Volume: 15, Issue:7 | High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle. |
| AID1347045 | Natriuretic polypeptide receptor (hNpr1) antagonism - Pilot counterscreen GloSensor control cell line | 2019 | Science translational medicine, 07-10, Volume: 11, Issue:500 | Inhibition of natriuretic peptide receptor 1 reduces itch in mice. |
| AID1347086 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID504836 | Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in human glioma: Validation | 2002 | The Journal of biological chemistry, Apr-19, Volume: 277, Issue:16 | Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. |
| AID1347050 | Natriuretic polypeptide receptor (hNpr2) antagonism - Pilot subtype selectivity assay | 2019 | Science translational medicine, 07-10, Volume: 11, Issue:500 | Inhibition of natriuretic peptide receptor 1 reduces itch in mice. |
| AID1347082 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347410 | qHTS for inhibitors of adenylyl cyclases using a fission yeast platform: a pilot screen against the NCATS LOPAC library | 2019 | Cellular signalling, 08, Volume: 60 | A fission yeast platform for heterologous expression of mammalian adenylyl cyclases and high throughput screening. |
| AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID1347405 | qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS LOPAC collection | 2020 | ACS chemical biology, 07-17, Volume: 15, Issue:7 | High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle. |
| AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID588378 | qHTS for Inhibitors of ATXN expression: Validation | |||
| AID761955 | Binding affinity to STAT3 beta (127 to 722) (unknown origin) expressed in Escherichia coli BL21 Rosetta at 50 uM after 1 hr by mass spectrophotometric analysis | 2013 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 23, Issue:16 | Investigation of the protein alkylation sites of the STAT3:STAT3 inhibitor Stattic by mass spectrometry. |
| AID1757393 | Antiproliferative activity against human MDA-MB-468 cells overexpressing STAT3 assessed as inhibition of cell growth incubated for 72 hrs by MTT assay | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Rational drug design of benzothiazole-based derivatives as potent signal transducer and activator of transcription 3 (STAT3) signaling pathway inhibitors. |
| AID1757424 | Displacement of 5'-FAM-GpYLPQTV-NH2 from His-tagged STAT3-SH2 domain (127 to 722 residues) (unknown origin) assessed as binding rate at 100 uM incubated for 30 mins followed by incubation with fluorescent probe for 1 hr by fluorescence polarization assay | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Rational drug design of benzothiazole-based derivatives as potent signal transducer and activator of transcription 3 (STAT3) signaling pathway inhibitors. |
| AID702274 | Inhibition of STAT3 SH2 domain using 5-carboxyfluorescein-GY(PO3H2)LPQTV-NH2 as substrate preincubated for 60 mins prior to substrate addition by fluorescence polarization assay | 2012 | Journal of medicinal chemistry, Aug-09, Volume: 55, Issue:15 | Small molecule inhibitors of signal transducer and activator of transcription 3 (Stat3) protein. |
| AID1583615 | Antitumor activity against mouse B16F10 cells implanted in C57BL/6 cells assessed as reduction in tumor burden at 50 mg/kg, iv administered once every 2 days for 3 weeks and measured after 21 days | 2020 | Journal of medicinal chemistry, 02-27, Volume: 63, Issue:4 | Bifunctional Naphthoquinone Aromatic Amide-Oxime Derivatives Exert Combined Immunotherapeutic and Antitumor Effects through Simultaneous Targeting of Indoleamine-2,3-dioxygenase and Signal Transducer and Activator of Transcription 3. |
| AID1155310 | Antiproliferative activity against human PANC1 cells assessed as inhibition of cell proliferation after 72 hrs by MTS assay | 2014 | European journal of medicinal chemistry, Jul-23, Volume: 82 | Discovery of potent anticancer agent HJC0416, an orally bioavailable small molecule inhibitor of signal transducer and activator of transcription 3 (STAT3). |
| AID1583614 | Antitumor activity against mouse B16F10 cells implanted in C57BL/6 cells assessed as reduction in tumor volume at 50 mg/kg, iv administered once every 2 days for 3 weeks and measured after 21 days | 2020 | Journal of medicinal chemistry, 02-27, Volume: 63, Issue:4 | Bifunctional Naphthoquinone Aromatic Amide-Oxime Derivatives Exert Combined Immunotherapeutic and Antitumor Effects through Simultaneous Targeting of Indoleamine-2,3-dioxygenase and Signal Transducer and Activator of Transcription 3. |
| AID1596402 | Inhibition of Src in human MDA-MB-231 cells assessed as reduction in Src phosphorylation at 4 uM incubated for 24 hrs by Western blot analysis | 2019 | European journal of medicinal chemistry, Jul-15, Volume: 174 | Discovery of fluorescent coumarin-benzo[b]thiophene 1, 1-dioxide conjugates as mitochondria-targeting antitumor STAT3 inhibitors. |
| AID1596403 | Inhibition of JAK2 in human MDA-MB-231 cells assessed as reduction in JAK2 phosphorylation at 4 uM incubated for 24 hrs by Western blot analysis | 2019 | European journal of medicinal chemistry, Jul-15, Volume: 174 | Discovery of fluorescent coumarin-benzo[b]thiophene 1, 1-dioxide conjugates as mitochondria-targeting antitumor STAT3 inhibitors. |
| AID1757425 | Displacement of 5'-FAM-GpYLPQTV-NH2 from His-tagged STAT3-SH2 domain (127 to 722 residues) (unknown origin) assessed as binding rate at 50 uM incubated for 30 mins followed by incubation with fluorescent probe for 1 hr by fluorescence polarization assay | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Rational drug design of benzothiazole-based derivatives as potent signal transducer and activator of transcription 3 (STAT3) signaling pathway inhibitors. |
| AID1752860 | Inhibition of Schistosoma mansoni thioredoxin glutathione reductase incubated for 30 mins by DTNB assay | 2020 | RSC medicinal chemistry, Apr-01, Volume: 11, Issue:4 | Chemotherapy for human schistosomiasis: how far have we come? What's new? Where do we go from here? |
| AID1596357 | Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay | 2019 | European journal of medicinal chemistry, Jul-15, Volume: 174 | Discovery of fluorescent coumarin-benzo[b]thiophene 1, 1-dioxide conjugates as mitochondria-targeting antitumor STAT3 inhibitors. |
| AID1337949 | Antiproliferative activity against human A549 cells after 72 hrs by MTT assay | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Antagonizing STAT3 activation with benzo[b]thiophene 1, 1-dioxide based small molecules. |
| AID1255296 | Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay | 2015 | ACS medicinal chemistry letters, Sep-10, Volume: 6, Issue:9 | Novel 2-Carbonylbenzo[b]thiophene 1,1-Dioxide Derivatives as Potent Inhibitors of STAT3 Signaling Pathway. |
| AID1739908 | Antiproliferative activity against human MDA-MB-231 cells overexpressing STAT3 assessed as reduction in cell growth incubated for 48 hrs by CCK-8 assay | 2020 | European journal of medicinal chemistry, Sep-01, Volume: 201 | Design, synthesis and biological evaluation of novel potent STAT3 inhibitors based on BBI608 for cancer therapy. |
| AID761953 | Binding affinity to STAT3 beta (127 to 722) (unknown origin) expressed in Escherichia coli BL21 Rosetta at 50 uM treated for 1 hr prior to trypsin digestion measured after 24 hrs by LC-MS/MS analysis in presence of ammonium bicarbonate and N-octyl-glucosi | 2013 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 23, Issue:16 | Investigation of the protein alkylation sites of the STAT3:STAT3 inhibitor Stattic by mass spectrometry. |
| AID1596358 | Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay | 2019 | European journal of medicinal chemistry, Jul-15, Volume: 174 | Discovery of fluorescent coumarin-benzo[b]thiophene 1, 1-dioxide conjugates as mitochondria-targeting antitumor STAT3 inhibitors. |
| AID1739909 | Antiproliferative activity against human MDA-MB-468 cells overexpressing STAT3 assessed as reduction in cell growth incubated for 48 hrs by CCK-8 assay | 2020 | European journal of medicinal chemistry, Sep-01, Volume: 201 | Design, synthesis and biological evaluation of novel potent STAT3 inhibitors based on BBI608 for cancer therapy. |
| AID1583621 | Toxicity in C57BL/6 mouse xenografted with wild type mouse B16F10 cells assessed as increase in body weight at 50 mg/kg, iv administered once every 2 days for 3 weeks and measured after 21 days | 2020 | Journal of medicinal chemistry, 02-27, Volume: 63, Issue:4 | Bifunctional Naphthoquinone Aromatic Amide-Oxime Derivatives Exert Combined Immunotherapeutic and Antitumor Effects through Simultaneous Targeting of Indoleamine-2,3-dioxygenase and Signal Transducer and Activator of Transcription 3. |
| AID1757395 | Antiproliferative activity against human MCF7 cells expressing low levels of STAT3 assessed as inhibition of cell growth incubated for 72 hrs by MTT assay | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Rational drug design of benzothiazole-based derivatives as potent signal transducer and activator of transcription 3 (STAT3) signaling pathway inhibitors. |
| AID1255290 | Inhibition of STAT3 phosphorylation at Y705 in human MDA-MB-231 cells after 12 hrs by Western blot analysis | 2015 | ACS medicinal chemistry letters, Sep-10, Volume: 6, Issue:9 | Novel 2-Carbonylbenzo[b]thiophene 1,1-Dioxide Derivatives as Potent Inhibitors of STAT3 Signaling Pathway. |
| AID1596365 | Cytotoxicity against human MCF10A cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay | 2019 | European journal of medicinal chemistry, Jul-15, Volume: 174 | Discovery of fluorescent coumarin-benzo[b]thiophene 1, 1-dioxide conjugates as mitochondria-targeting antitumor STAT3 inhibitors. |
| AID1255301 | Inhibition of STAT3-mediated luciferase activity in human HeLa cells at 4 uM after 12 hrs by luminescence assay relative to control | 2015 | ACS medicinal chemistry letters, Sep-10, Volume: 6, Issue:9 | Novel 2-Carbonylbenzo[b]thiophene 1,1-Dioxide Derivatives as Potent Inhibitors of STAT3 Signaling Pathway. |
| AID1752861 | Antischistosomal activity against Schistosoma japonicum assessed as worm death at 10 uM incubated for 120 hrs relative to control | 2020 | RSC medicinal chemistry, Apr-01, Volume: 11, Issue:4 | Chemotherapy for human schistosomiasis: how far have we come? What's new? Where do we go from here? |
| AID1255293 | Cytotoxicity against human MCF7 cells assessed as growth inhibition after 48 hrs by MTT assay | 2015 | ACS medicinal chemistry letters, Sep-10, Volume: 6, Issue:9 | Novel 2-Carbonylbenzo[b]thiophene 1,1-Dioxide Derivatives as Potent Inhibitors of STAT3 Signaling Pathway. |
| AID1255294 | Cytotoxicity against human DU145 cells assessed as growth inhibition after 48 hrs by MTT assay | 2015 | ACS medicinal chemistry letters, Sep-10, Volume: 6, Issue:9 | Novel 2-Carbonylbenzo[b]thiophene 1,1-Dioxide Derivatives as Potent Inhibitors of STAT3 Signaling Pathway. |
| AID1757394 | Antiproliferative activity against human MDA-MB-453 cells expressing low levels of STAT3 assessed as inhibition of cell growth incubated for 72 hrs by MTT assay | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Rational drug design of benzothiazole-based derivatives as potent signal transducer and activator of transcription 3 (STAT3) signaling pathway inhibitors. |
| AID1596406 | Induction of apoptosis in human MDA-MB-231 cells assessed as increase in cleaved caspase-3 levels at 4 uM incubated for 24 hrs by Western blot analysis | 2019 | European journal of medicinal chemistry, Jul-15, Volume: 174 | Discovery of fluorescent coumarin-benzo[b]thiophene 1, 1-dioxide conjugates as mitochondria-targeting antitumor STAT3 inhibitors. |
| AID1596391 | Inhibition of STAT3 in human MDA-MB-231 cells assessed as decrease in STAT3 phosphorylation at Tyr705 residue at 4 uM incubated for 24 hrs by Western blot analysis | 2019 | European journal of medicinal chemistry, Jul-15, Volume: 174 | Discovery of fluorescent coumarin-benzo[b]thiophene 1, 1-dioxide conjugates as mitochondria-targeting antitumor STAT3 inhibitors. |
| AID1596405 | Induction of apoptosis in human MDA-MB-231 cells assessed as increase in cleaved caspase-9 levels at 4 uM incubated for 24 hrs by Western blot analysis | 2019 | European journal of medicinal chemistry, Jul-15, Volume: 174 | Discovery of fluorescent coumarin-benzo[b]thiophene 1, 1-dioxide conjugates as mitochondria-targeting antitumor STAT3 inhibitors. |
| AID1255295 | Cytotoxicity against human PANC1 cells assessed as growth inhibition after 48 hrs by MTT assay | 2015 | ACS medicinal chemistry letters, Sep-10, Volume: 6, Issue:9 | Novel 2-Carbonylbenzo[b]thiophene 1,1-Dioxide Derivatives as Potent Inhibitors of STAT3 Signaling Pathway. |
| AID1757426 | Displacement of 5'-FAM-GpYLPQTV-NH2 from His-tagged STAT3-SH2 domain (127 to 722 residues) (unknown origin) assessed as binding rate at 20 uM incubated for 30 mins followed by incubation with fluorescent probe for 1 hr by fluorescence polarization assay | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Rational drug design of benzothiazole-based derivatives as potent signal transducer and activator of transcription 3 (STAT3) signaling pathway inhibitors. |
| AID1155308 | Antiproliferative activity against ER-negative and triple-negative human MDA-MB-231 cells assessed as inhibition of cell proliferation after 72 hrs by MTS assay | 2014 | European journal of medicinal chemistry, Jul-23, Volume: 82 | Discovery of potent anticancer agent HJC0416, an orally bioavailable small molecule inhibitor of signal transducer and activator of transcription 3 (STAT3). |
| AID1337951 | Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Antagonizing STAT3 activation with benzo[b]thiophene 1, 1-dioxide based small molecules. |
| AID1639059 | Binding affinity to Cys255 residue of C-terminal Avi/FLAG-tagged HIF-1alpha (unknown origin) after 1 hr by AlphaScreen assay | 2019 | Bioorganic & medicinal chemistry, 04-01, Volume: 27, Issue:7 | Advances in inhibition of protein-protein interactions targeting hypoxia-inducible factor-1 for cancer therapy. |
| AID1583616 | Antitumor activity against mouse B16F10 cells implanted in C57BL/6 cells assessed as tumor growth inhibition at 50 mg/kg, iv administered once every 2 days for 3 weeks and measured after 21 days relative to control | 2020 | Journal of medicinal chemistry, 02-27, Volume: 63, Issue:4 | Bifunctional Naphthoquinone Aromatic Amide-Oxime Derivatives Exert Combined Immunotherapeutic and Antitumor Effects through Simultaneous Targeting of Indoleamine-2,3-dioxygenase and Signal Transducer and Activator of Transcription 3. |
| AID1155312 | Inhibition of STAT3 promoter activity in human MDA-MB-231 cells at 5 uM after 24 hrs by dual luciferase reporter assay | 2014 | European journal of medicinal chemistry, Jul-23, Volume: 82 | Discovery of potent anticancer agent HJC0416, an orally bioavailable small molecule inhibitor of signal transducer and activator of transcription 3 (STAT3). |
| AID1155313 | Decrease in STAT3 protein expression in human MDA-MB-231 cells at 1 to 10 uM after 12 hrs by western blot analysis | 2014 | European journal of medicinal chemistry, Jul-23, Volume: 82 | Discovery of potent anticancer agent HJC0416, an orally bioavailable small molecule inhibitor of signal transducer and activator of transcription 3 (STAT3). |
| AID1596360 | Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay | 2019 | European journal of medicinal chemistry, Jul-15, Volume: 174 | Discovery of fluorescent coumarin-benzo[b]thiophene 1, 1-dioxide conjugates as mitochondria-targeting antitumor STAT3 inhibitors. |
| AID761952 | Binding affinity to STAT3 beta (127 to 722) (unknown origin) expressed in Escherichia coli BL21 Rosetta at 50 uM treated for 1 hr prior to trypsin digestion measured after 24 hrs by LC-MS/MS analysis in presence of ammonium bicarbonate and acetonitrile | 2013 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 23, Issue:16 | Investigation of the protein alkylation sites of the STAT3:STAT3 inhibitor Stattic by mass spectrometry. |
| AID1255303 | Inhibition of STAT3 phosphorylation at Y705 in human MCF7 cells after 12 hrs by Western blot analysis | 2015 | ACS medicinal chemistry letters, Sep-10, Volume: 6, Issue:9 | Novel 2-Carbonylbenzo[b]thiophene 1,1-Dioxide Derivatives as Potent Inhibitors of STAT3 Signaling Pathway. |
| AID1596409 | Inhibition of STAT3 in human MDA-MB-231 cells assessed as decrease in STAT3-DNA binding at 4 uM incubated for 24 hrs by electrophoretic mobility shift assay | 2019 | European journal of medicinal chemistry, Jul-15, Volume: 174 | Discovery of fluorescent coumarin-benzo[b]thiophene 1, 1-dioxide conjugates as mitochondria-targeting antitumor STAT3 inhibitors. |
| AID1596408 | Inhibition of STAT1 in human MDA-MB-231 cells assessed as decrease in STAT1 phosphorylation at Y701 residue at 4 uM incubated for 24 hrs by Western blot analysis | 2019 | European journal of medicinal chemistry, Jul-15, Volume: 174 | Discovery of fluorescent coumarin-benzo[b]thiophene 1, 1-dioxide conjugates as mitochondria-targeting antitumor STAT3 inhibitors. |
| AID1337948 | Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Antagonizing STAT3 activation with benzo[b]thiophene 1, 1-dioxide based small molecules. |
| AID1752872 | Antischistosomal activity against juvenile Schistosoma mansoni assessed as worm death at 10 uM incubated for 72 hrs relative to control | 2020 | RSC medicinal chemistry, Apr-01, Volume: 11, Issue:4 | Chemotherapy for human schistosomiasis: how far have we come? What's new? Where do we go from here? |
| AID761954 | Binding affinity to STAT3 beta (127 to 722) (unknown origin) expressed in Escherichia coli BL21 Rosetta at 50 uM treated for 1 hr prior to trypsin digestion measured after 24 hrs by LC-MS/MS analysis in presence of ammonium bicarbonate | 2013 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 23, Issue:16 | Investigation of the protein alkylation sites of the STAT3:STAT3 inhibitor Stattic by mass spectrometry. |
| AID761951 | Binding affinity to STAT3 beta (127 to 722) (unknown origin) expressed in Escherichia coli BL21 Rosetta at 50 uM treated for 1 hr prior to trypsin digestion measured after 24 hrs by LC-MS/MS analysis in presence of ammonium bicarbonate and guanidium HCl | 2013 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 23, Issue:16 | Investigation of the protein alkylation sites of the STAT3:STAT3 inhibitor Stattic by mass spectrometry. |
| AID1155309 | Antiproliferative activity against human AsPC1 cells assessed as inhibition of cell proliferation after 72 hrs by MTS assay | 2014 | European journal of medicinal chemistry, Jul-23, Volume: 82 | Discovery of potent anticancer agent HJC0416, an orally bioavailable small molecule inhibitor of signal transducer and activator of transcription 3 (STAT3). |
| AID1596407 | Induction of apoptosis in human MDA-MB-231 cells assessed as increase in cleaved PARP levels at 4 uM incubated for 24 hrs by Western blot analysis | 2019 | European journal of medicinal chemistry, Jul-15, Volume: 174 | Discovery of fluorescent coumarin-benzo[b]thiophene 1, 1-dioxide conjugates as mitochondria-targeting antitumor STAT3 inhibitors. |
| AID1155307 | Antiproliferative activity against ER-positive human MCF7 cells assessed as inhibition of cell proliferation after 72 hrs by MTS assay | 2014 | European journal of medicinal chemistry, Jul-23, Volume: 82 | Discovery of potent anticancer agent HJC0416, an orally bioavailable small molecule inhibitor of signal transducer and activator of transcription 3 (STAT3). |
| AID1255302 | Inhibition of STAT3 phosphorylation at Y705 in human MDA-MB-435S cells after 12 hrs by Western blot analysis | 2015 | ACS medicinal chemistry letters, Sep-10, Volume: 6, Issue:9 | Novel 2-Carbonylbenzo[b]thiophene 1,1-Dioxide Derivatives as Potent Inhibitors of STAT3 Signaling Pathway. |
| AID1596368 | Selectivity index, ratio of IC50 for human L02 cells to IC50 for human HepG2 cells | 2019 | European journal of medicinal chemistry, Jul-15, Volume: 174 | Discovery of fluorescent coumarin-benzo[b]thiophene 1, 1-dioxide conjugates as mitochondria-targeting antitumor STAT3 inhibitors. |
| AID1596366 | Cytotoxicity against human LO2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay | 2019 | European journal of medicinal chemistry, Jul-15, Volume: 174 | Discovery of fluorescent coumarin-benzo[b]thiophene 1, 1-dioxide conjugates as mitochondria-targeting antitumor STAT3 inhibitors. |
| AID1752870 | Antischistosomal activity against adult Schistosoma mansoni assessed as worm death at 10 uM incubated for 144 hrs relative to control | 2020 | RSC medicinal chemistry, Apr-01, Volume: 11, Issue:4 | Chemotherapy for human schistosomiasis: how far have we come? What's new? Where do we go from here? |
| AID1337960 | Inhibition of STAT3 dimer DNA binding activity in human MDA-MB-231 nuclear extract at 5 uM preincubated for 24 hrs followed by addition of [32P]hSIE by electrophoretic mobility shift assay | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Antagonizing STAT3 activation with benzo[b]thiophene 1, 1-dioxide based small molecules. |
| AID1155314 | Inhibition of STAT3 phosphorylation at Tyr705 in human MDA-MB-231 cells at 1 to 10 uM after 12 hrs by western blot analysis | 2014 | European journal of medicinal chemistry, Jul-23, Volume: 82 | Discovery of potent anticancer agent HJC0416, an orally bioavailable small molecule inhibitor of signal transducer and activator of transcription 3 (STAT3). |
| AID1909687 | Inhibition of STAT3-SH2 (unknown origin) using 5-carboxyfluorescein-GY(PO3H2)EEIP as substrate incubated with compound for 1 hr followed by substrate addition by fluorescence polarization assay | 2022 | Journal of medicinal chemistry, 05-12, Volume: 65, Issue:9 | Discovery of 2-Amino-3-cyanothiophene Derivatives as Potent STAT3 Inhibitors for the Treatment of Osteosarcoma Growth and Metastasis. |
| AID1255292 | Cytotoxicity against human MDA-MB-435S cells assessed as growth inhibition after 48 hrs by MTT assay | 2015 | ACS medicinal chemistry letters, Sep-10, Volume: 6, Issue:9 | Novel 2-Carbonylbenzo[b]thiophene 1,1-Dioxide Derivatives as Potent Inhibitors of STAT3 Signaling Pathway. |
| AID1639072 | Binding affinity to HIF-1alpha (unknown origin) PAS B domain assessed as incorporation at Cys255 residues by mass spectrometry | 2019 | Bioorganic & medicinal chemistry, 04-01, Volume: 27, Issue:7 | Advances in inhibition of protein-protein interactions targeting hypoxia-inducible factor-1 for cancer therapy. |
| AID1752864 | Antischistosomal activity against Schistosoma haematobium assessed as worm death at 10 uM incubated for 120 hrs relative to control | 2020 | RSC medicinal chemistry, Apr-01, Volume: 11, Issue:4 | Chemotherapy for human schistosomiasis: how far have we come? What's new? Where do we go from here? |
| AID1155311 | Anticancer activity against human MDA-MB-231 cells assessed as cell growth inhibition, apoptosis and cellular morphological changes at 1 to 10 uM after 48 hrs by light microscopy | 2014 | European journal of medicinal chemistry, Jul-23, Volume: 82 | Discovery of potent anticancer agent HJC0416, an orally bioavailable small molecule inhibitor of signal transducer and activator of transcription 3 (STAT3). |
| AID1596359 | Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay | 2019 | European journal of medicinal chemistry, Jul-15, Volume: 174 | Discovery of fluorescent coumarin-benzo[b]thiophene 1, 1-dioxide conjugates as mitochondria-targeting antitumor STAT3 inhibitors. |
| AID1596410 | Inhibition of ERK 1/2 in human MDA-MB-231 cells assessed as reduction in ERK 1/2 phosphorylation at 4 uM incubated for 24 hrs by Western blot analysis | 2019 | European journal of medicinal chemistry, Jul-15, Volume: 174 | Discovery of fluorescent coumarin-benzo[b]thiophene 1, 1-dioxide conjugates as mitochondria-targeting antitumor STAT3 inhibitors. |
| AID1255291 | Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 48 hrs by MTT assay | 2015 | ACS medicinal chemistry letters, Sep-10, Volume: 6, Issue:9 | Novel 2-Carbonylbenzo[b]thiophene 1,1-Dioxide Derivatives as Potent Inhibitors of STAT3 Signaling Pathway. |
| AID1362928 | Inhibition of IFNgamma-stimulated GFP/FLAG-tagged STAT3 dimerization in human AD293 cells incubated for 6 hrs by Western blot analysis | 2018 | Bioorganic & medicinal chemistry, 10-01, Volume: 26, Issue:18 | Andrographolide derivative as STAT3 inhibitor that protects acute liver damage in mice. |
| AID1337950 | Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Antagonizing STAT3 activation with benzo[b]thiophene 1, 1-dioxide based small molecules. |
| AID1596367 | Selectivity index, ratio of IC50 for human MCF10A cells to IC50 for human MDA-MB-231 cells | 2019 | European journal of medicinal chemistry, Jul-15, Volume: 174 | Discovery of fluorescent coumarin-benzo[b]thiophene 1, 1-dioxide conjugates as mitochondria-targeting antitumor STAT3 inhibitors. |
| AID1752857 | Antischistosomal activity against Schistosoma mansoni Schistosomula assessed as worm death at 10 uM incubated for 24 hrs relative to control | 2020 | RSC medicinal chemistry, Apr-01, Volume: 11, Issue:4 | Chemotherapy for human schistosomiasis: how far have we come? What's new? Where do we go from here? |
| AID1757423 | Binding affinity to His-tagged STAT3-SH2 domain (127 to 722 residues) (unknown origin) by surface plasmon resonance analysis | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Rational drug design of benzothiazole-based derivatives as potent signal transducer and activator of transcription 3 (STAT3) signaling pathway inhibitors. |
| AID1757392 | Antiproliferative activity against human HEL cells harboring JAK2 V617F mutant assessed as inhibition of cell growth incubated for 72 hrs by MTT assay | 2021 | European journal of medicinal chemistry, Apr-15, Volume: 216 | Rational drug design of benzothiazole-based derivatives as potent signal transducer and activator of transcription 3 (STAT3) signaling pathway inhibitors. |
| AID1794808 | Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL). | 2014 | Journal of biomolecular screening, Jul, Volume: 19, Issue:6 | A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum. |
| AID1794808 | Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL). | |||
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (141)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (4.26) | 29.6817 |
| 2010's | 86 (60.99) | 24.3611 |
| 2020's | 49 (34.75) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 40.95
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.
| This Compound (40.95) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 4 (2.82%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 138 (97.18%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||