dothiepin-hydrochloride and Necrosis

Hypotensive hemorrhagic necrosis of the basal ganglia and brainstem has only occasionally been described. Three such cases are reported. Cardiac arrest had occurred in all cases, and it took at least 1 hour to restore adequate circulation. The patients remained comatose for 2 days to 2 weeks until death. Persistent hypotension causing ischemia in the distribution of deep perforating arteries is considered to have been the key underlying mechanism. Hemorrhage is thought to have been caused by extravasation of red blood cells through damaged blood vessels.

Topics: Adult; Autopsy; Basal Ganglia Hemorrhage; Brain Stem; Cerebral Hemorrhage; Cerebral Palsy; Dothiepin; Drowning; Epilepsy; Extravasation of Diagnostic and Therapeutic Materials; Fatal Outcome; Heart Arrest; Hippocampus; Humans; Hypotension; Male; Middle Aged; Necrosis; Reperfusion Injury; Suicide

Selective necrosis of rat testicles is known to be produced by cadmium in subtoxic doses due to impairment of vessel structures. Classical antihistaminics in the same time in order to exclude that the lesion might have been produced by local release of histamine. Antihistaminics did not prevent necrosis. Instead, Clemastine stressed an interstitial testicular haemorrhage a bit. Methyldosulepine administered with calcium could decrease the vascular permeability because haemorrhage was almost lacking. The finding supports an idea of possible interaction between calcium and cadmium ions.

Topics: Animals; Cadmium; Clemastine; Dibenzothiepins; Dothiepin; Histamine H1 Antagonists; Male; Necrosis; Pyrrolidines; Rats; Sugar Acids; Testicular Diseases; Testis