fasudil has been researched along with Necrosis in 5 studies
fasudil: intracellular calcium antagonist; structure in first source
fasudil : An isoquinoline substituted by a (1,4-diazepan-1-yl)sulfonyl group at position 5. It is a Rho-kinase inhibitor and its hydrochloride hydrate form is approved for the treatment of cerebral vasospasm and cerebral ischemia.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "After cerebral ischemia, the volume of cerebral necrosis was reduced in wild-type mice treated with Fasudil." | 8.31 | Fasudil mediates neuroprotection in ischemia/reperfusion by modulating the ROCK-PPARα-NOX axis. ( Wang, G; Yang, X, 2023) |
| "To investigate whether there exists a cardio-protective effect of Fasudil, a selective Rho kinase (ROCK) inhibitor, in an experimental murine model of acute viral myocarditis." | 7.88 | Fasudil exerts a cardio-protective effect on mice with coxsackievirus B3-induced acute viral myocarditis. ( Chen, Q; Dai, K; Kuver, A; Li, J; Lian, H; Liao, W; Ni, H; Tai, S; Wang, Y; Yu, Y; Zheng, C, 2018) |
| "After cerebral ischemia, the volume of cerebral necrosis was reduced in wild-type mice treated with Fasudil." | 4.31 | Fasudil mediates neuroprotection in ischemia/reperfusion by modulating the ROCK-PPARα-NOX axis. ( Wang, G; Yang, X, 2023) |
| "In conclusion, fasudil treatment decreased necrosis of perforator flaps possibly by affecting the Akt/eNOS/NO pathway, attenuating apoptosis and activating autophagy." | 3.96 | Pharmacological Effects of Fasudil on Flap Survival in a Rodent Model. ( Gao, W; Ji, E; Pan, Z; Wang, J; Wang, L, 2020) |
| "To investigate whether there exists a cardio-protective effect of Fasudil, a selective Rho kinase (ROCK) inhibitor, in an experimental murine model of acute viral myocarditis." | 3.88 | Fasudil exerts a cardio-protective effect on mice with coxsackievirus B3-induced acute viral myocarditis. ( Chen, Q; Dai, K; Kuver, A; Li, J; Lian, H; Liao, W; Ni, H; Tai, S; Wang, Y; Yu, Y; Zheng, C, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 3 (60.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, H | 1 |
| Fang, F | 1 |
| Chen, S | 1 |
| Jing, X | 1 |
| Zhuang, Y | 1 |
| Xie, Y | 1 |
| Yang, X | 1 |
| Wang, G | 1 |
| Ji, E | 1 |
| Wang, J | 1 |
| Wang, L | 1 |
| Pan, Z | 1 |
| Gao, W | 1 |
| Dai, K | 1 |
| Wang, Y | 1 |
| Tai, S | 1 |
| Ni, H | 1 |
| Lian, H | 1 |
| Yu, Y | 1 |
| Liao, W | 1 |
| Zheng, C | 1 |
| Chen, Q | 1 |
| Kuver, A | 1 |
| Li, J | 1 |
| Yamamoto, Y | 1 |
| Ikegaki, I | 1 |
| Sasaki, Y | 1 |
| Uchida, T | 1 |
5 other studies available for fasudil and Necrosis
| Article | Year |
|---|---|
Dual efficacy of Fasudil at improvement of survival and reinnervation of flap through RhoA/ROCK/PI3K/Akt pathway.
Topics: Animals; Mice; Necrosis; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Vascular End | 2022 |
Fasudil mediates neuroprotection in ischemia/reperfusion by modulating the ROCK-PPARα-NOX axis.
Topics: Animals; Brain Ischemia; Ischemia; Male; Mice; Mice, Inbred C57BL; NADPH Oxidases; Necrosis; Neuropr | 2023 |
Pharmacological Effects of Fasudil on Flap Survival in a Rodent Model.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apoptosis; Autophagy; Disease Models, Animal | 2020 |
Fasudil exerts a cardio-protective effect on mice with coxsackievirus B3-induced acute viral myocarditis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Anti-Inflammatory Agents; Antiviral Agents; | 2018 |
The protein kinase inhibitor fasudil protects against ischemic myocardial injury induced by endothelin-1 in the rabbit.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Movement; Diltiazem; Electrocardiograph | 2000 |