Page last updated: 2024-10-28

fasudil and Necrosis

fasudil has been researched along with Necrosis in 5 studies

fasudil: intracellular calcium antagonist; structure in first source
fasudil : An isoquinoline substituted by a (1,4-diazepan-1-yl)sulfonyl group at position 5. It is a Rho-kinase inhibitor and its hydrochloride hydrate form is approved for the treatment of cerebral vasospasm and cerebral ischemia.

Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.

Research Excerpts

ExcerptRelevanceReference
"After cerebral ischemia, the volume of cerebral necrosis was reduced in wild-type mice treated with Fasudil."8.31Fasudil mediates neuroprotection in ischemia/reperfusion by modulating the ROCK-PPARα-NOX axis. ( Wang, G; Yang, X, 2023)
"To investigate whether there exists a cardio-protective effect of Fasudil, a selective Rho kinase (ROCK) inhibitor, in an experimental murine model of acute viral myocarditis."7.88Fasudil exerts a cardio-protective effect on mice with coxsackievirus B3-induced acute viral myocarditis. ( Chen, Q; Dai, K; Kuver, A; Li, J; Lian, H; Liao, W; Ni, H; Tai, S; Wang, Y; Yu, Y; Zheng, C, 2018)
"After cerebral ischemia, the volume of cerebral necrosis was reduced in wild-type mice treated with Fasudil."4.31Fasudil mediates neuroprotection in ischemia/reperfusion by modulating the ROCK-PPARα-NOX axis. ( Wang, G; Yang, X, 2023)
"In conclusion, fasudil treatment decreased necrosis of perforator flaps possibly by affecting the Akt/eNOS/NO pathway, attenuating apoptosis and activating autophagy."3.96Pharmacological Effects of Fasudil on Flap Survival in a Rodent Model. ( Gao, W; Ji, E; Pan, Z; Wang, J; Wang, L, 2020)
"To investigate whether there exists a cardio-protective effect of Fasudil, a selective Rho kinase (ROCK) inhibitor, in an experimental murine model of acute viral myocarditis."3.88Fasudil exerts a cardio-protective effect on mice with coxsackievirus B3-induced acute viral myocarditis. ( Chen, Q; Dai, K; Kuver, A; Li, J; Lian, H; Liao, W; Ni, H; Tai, S; Wang, Y; Yu, Y; Zheng, C, 2018)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's1 (20.00)24.3611
2020's3 (60.00)2.80

Authors

AuthorsStudies
Wang, H1
Fang, F1
Chen, S1
Jing, X1
Zhuang, Y1
Xie, Y1
Yang, X1
Wang, G1
Ji, E1
Wang, J1
Wang, L1
Pan, Z1
Gao, W1
Dai, K1
Wang, Y1
Tai, S1
Ni, H1
Lian, H1
Yu, Y1
Liao, W1
Zheng, C1
Chen, Q1
Kuver, A1
Li, J1
Yamamoto, Y1
Ikegaki, I1
Sasaki, Y1
Uchida, T1

Other Studies

5 other studies available for fasudil and Necrosis

ArticleYear
Dual efficacy of Fasudil at improvement of survival and reinnervation of flap through RhoA/ROCK/PI3K/Akt pathway.
    International wound journal, 2022, Volume: 19, Issue:8

    Topics: Animals; Mice; Necrosis; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Vascular End

2022
Fasudil mediates neuroprotection in ischemia/reperfusion by modulating the ROCK-PPARα-NOX axis.
    Acta cirurgica brasileira, 2023, Volume: 38

    Topics: Animals; Brain Ischemia; Ischemia; Male; Mice; Mice, Inbred C57BL; NADPH Oxidases; Necrosis; Neuropr

2023
Pharmacological Effects of Fasudil on Flap Survival in a Rodent Model.
    The Journal of surgical research, 2020, Volume: 255

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apoptosis; Autophagy; Disease Models, Animal

2020
Fasudil exerts a cardio-protective effect on mice with coxsackievirus B3-induced acute viral myocarditis.
    Cardiovascular therapeutics, 2018, Volume: 36, Issue:6

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Anti-Inflammatory Agents; Antiviral Agents;

2018
The protein kinase inhibitor fasudil protects against ischemic myocardial injury induced by endothelin-1 in the rabbit.
    Journal of cardiovascular pharmacology, 2000, Volume: 35, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Movement; Diltiazem; Electrocardiograph

2000