NADPH--cytochrome P450 reductase

An NADPH--cytochrome P450 reductase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P16435]

CPR;
P450R;
EC 1.6.2.4

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
beta-lapachone	Homo sapiens (human)	IC50	11.0000	1	1

This protein enables 5 target(s):

Target	Category	Definition
NADPH-hemoprotein reductase activity	molecular function	Catalysis of the reaction: NADPH + H+ + n oxidized hemoprotein = NADP+ + n reduced hemoprotein. [EC:1.6.2.4]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
NADP binding	molecular function	Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. [GOC:ai]
FMN binding	molecular function	Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. [GOC:tb]
flavin adenine dinucleotide binding	molecular function	Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. [GOC:ai, GOC:imk, ISBN:0198506732]

This protein is located in 3 target(s):

Target	Category	Definition
endoplasmic reticulum membrane	cellular component	The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
intracellular membrane-bounded organelle	cellular component	Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. [GOC:go_curators]

This protein is active in 1 target(s):

Target	Category	Definition
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

This protein is involved in 5 target(s):

Target	Category	Definition
xenobiotic metabolic process	biological process	The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:cab2, GOC:krc]
electron transport chain	biological process	A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors. [GOC:mtg_electron_transport]
positive regulation of monooxygenase activity	biological process	Any process that activates or increases the activity of a monooxygenase. [GOC:mah]
cellular organofluorine metabolic process	biological process	The chemical reactions and pathways involving organofluorine compounds, as carried out by individual cells. [GOC:BHF]
response to hormone	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. [GOC:jl]