Proteins > cGMP-specific 3',5'-cyclic phosphodiesterase
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cGMP-specific 3',5'-cyclic phosphodiesterase
A cGMP-specific 3,5-cyclic phosphodiesterase that is encoded in the genome of cow. [OMA:Q28156, PRO:DNx]
Synonyms
EC 3.1.4.35;
cGMP-binding cGMP-specific phosphodiesterase;
CGB-PDE
Research
Bioassay Publications (12)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 1 (8.33) | 18.7374 |
| 1990's | 2 (16.67) | 18.2507 |
| 2000's | 4 (33.33) | 29.6817 |
| 2010's | 5 (41.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (13)
Drugs with Inhibition Measurements
Identification of chalcones as potent and selective PDE5A1 inhibitors.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 22, Issue:12, 2012
Studies of cardiotonic agents. 8. Synthesis and biological activities of optically active 6-(4-(benzylamino)-7-quinazolinyl)-4,5-dihydro-5-methyl-3(2H)- pyridazinone (KF15232).Journal of medicinal chemistry, , Jan-05, Volume: 39, Issue:1, 1996
Inhibition of cyclic adenosine-3',5'-monophosphate phosphodiesterase from vascular smooth muscle by rolipram analogues.Journal of medicinal chemistry, , Volume: 32, Issue:7, 1989
The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. 1: 5,6,11,11a-tetrahydro-1H-imidazo[1',5':1,6]pyrido[3,4-b]indole-1,3(2H)-dione analogues.Journal of medicinal chemistry, , Oct-09, Volume: 46, Issue:21, 2003
Drug-to-genome-to-drug, step 2: reversing selectivity in a series of antiplasmodial compounds.Journal of medicinal chemistry, , Feb-09, Volume: 55, Issue:3, 2012
Discovery of potent, selective, and orally bioavailable PDE5 inhibitor: Methyl-4-(3-chloro-4-methoxybenzylamino)-8-(2-hydroxyethyl)-7-methoxyquinazolin-6-ylmethylcarbamate (CKD 533).Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 20, Issue:1, 2010
Quinazolines as potent and highly selective PDE5 inhibitors as potential therapeutics for male erectile dysfunction.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 18, Issue:23, 2008
PDE5 inhibitors: An original access to novel potent arylated analogues of tadalafil.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 17, Issue:3, 2007
The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. 2: 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione analogues.Journal of medicinal chemistry, , Oct-09, Volume: 46, Issue:21, 2003
Design and synthesis of 3-aminophthalazine derivatives and structural analogues as PDE5 inhibitors: anti-allodynic effect against neuropathic pain in a mouse model.European journal of medicinal chemistry, , Sep-01, Volume: 177, 2019
Identification of chalcones as potent and selective PDE5A1 inhibitors.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 22, Issue:12, 2012
Discovery of potent, selective, and orally bioavailable PDE5 inhibitor: Methyl-4-(3-chloro-4-methoxybenzylamino)-8-(2-hydroxyethyl)-7-methoxyquinazolin-6-ylmethylcarbamate (CKD 533).Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 20, Issue:1, 2010
Quinazolines as potent and highly selective PDE5 inhibitors as potential therapeutics for male erectile dysfunction.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 18, Issue:23, 2008
The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. 2: 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione analogues.Journal of medicinal chemistry, , Oct-09, Volume: 46, Issue:21, 2003
The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. 1: 5,6,11,11a-tetrahydro-1H-imidazo[1',5':1,6]pyrido[3,4-b]indole-1,3(2H)-dione analogues.Journal of medicinal chemistry, , Oct-09, Volume: 46, Issue:21, 2003
Design and synthesis of 3-aminophthalazine derivatives and structural analogues as PDE5 inhibitors: anti-allodynic effect against neuropathic pain in a mouse model.European journal of medicinal chemistry, , Sep-01, Volume: 177, 2019
Identification of chalcones as potent and selective PDE5A1 inhibitors.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 22, Issue:12, 2012
The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. 1: 5,6,11,11a-tetrahydro-1H-imidazo[1',5':1,6]pyrido[3,4-b]indole-1,3(2H)-dione analogues.Journal of medicinal chemistry, , Oct-09, Volume: 46, Issue:21, 2003
Potent tetracyclic guanine inhibitors of PDE1 and PDE5 cyclic guanosine monophosphate phosphodiesterases with oral antihypertensive activity.Journal of medicinal chemistry, , Jul-04, Volume: 40, Issue:14, 1997