Proteins > Metabotropic glutamate receptor 4
Page last updated: 2024-08-07 17:08:28
Metabotropic glutamate receptor 4
A metabotropic glutamate receptor 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14833]
Synonyms
mGluR4
Research
Bioassay Publications (28)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (32.14) | 18.2507 |
| 2000's | 11 (39.29) | 29.6817 |
| 2010's | 7 (25.00) | 24.3611 |
| 2020's | 1 (3.57) | 2.80 |
Compounds (43)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| alpha-methyl-4-carboxyphenylglycine | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| alpha-methyl-4-carboxyphenylglycine | Homo sapiens (human) | Ki | 1,000.0000 | 1 | 1 |
| ibotenic acid | Homo sapiens (human) | Ki | 1,000.0000 | 1 | 1 |
| 4-carboxy-3-hydroxyphenylglycine | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| 4-carboxy-3-hydroxyphenylglycine | Homo sapiens (human) | Ki | 1,000.0000 | 1 | 1 |
| 1-aminoindan-1,5-dicarboxylic acid | Homo sapiens (human) | Ki | 1,000.0000 | 1 | 1 |
| 4-carboxyphenylglycine | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| glutamic acid | Homo sapiens (human) | Ki | 5.6000 | 4 | 4 |
| quisqualic acid | Homo sapiens (human) | Ki | 556.0000 | 2 | 2 |
| L-2-aminoadipic acid | Homo sapiens (human) | Ki | 3,000.0000 | 1 | 1 |
| 1-amino-1,3-dicarboxycyclopentane | Homo sapiens (human) | Ki | 98.0000 | 1 | 1 |
| homocysteic acid | Homo sapiens (human) | Ki | 53.0000 | 1 | 1 |
| 2-amino-4-phosphonobutyric acid | Homo sapiens (human) | Ki | 0.5133 | 3 | 3 |
| eglumetad | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| 3,5-dihydroxyphenylglycine | Homo sapiens (human) | Ki | 1,000.0000 | 1 | 1 |
| 6-methyl-2-(phenylethynyl)pyridine | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| 4-methylglutamic acid, threo-(l)-isomer | Homo sapiens (human) | Ki | 470.0000 | 1 | 1 |
| sib 1757 | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| l-2-(carboxypropyl)glycine | Homo sapiens (human) | Ki | 50.0000 | 1 | 1 |
| 2r,4r-4-aminopyrrolidine-2,4-dicarboxylate | Homo sapiens (human) | Ki | 300.0000 | 1 | 1 |
| upf 596 | Homo sapiens (human) | IC50 | 300.0000 | 1 | 1 |
| upf 596 | Homo sapiens (human) | Ki | 300.0000 | 1 | 1 |
| sib 1893 | Homo sapiens (human) | Ki | 26.0000 | 1 | 1 |
| ly 341495 | Homo sapiens (human) | IC50 | 22.0000 | 1 | 1 |
| ly 341495 | Homo sapiens (human) | Ki | 22.0000 | 1 | 1 |
| ly 389795 | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| ly 379268 | Homo sapiens (human) | Ki | 21.0000 | 1 | 1 |
| a 794282 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| sp 203 | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| vu0361737 | Homo sapiens (human) | IC50 | 0.0051 | 1 | 2 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| ibotenic acid | Homo sapiens (human) | EC50 | 1,000.0000 | 1 | 1 |
| 2-amino-4-phosphonobutyric acid | Homo sapiens (human) | EC50 | 0.3300 | 1 | 1 |
| glutamic acid | Homo sapiens (human) | EC50 | 14.9333 | 3 | 3 |
| quisqualic acid | Homo sapiens (human) | EC50 | 500.0000 | 1 | 1 |
| plasmenylserine | Homo sapiens (human) | EC50 | 1.1500 | 2 | 2 |
| 1-amino-1,3-dicarboxycyclopentane, (trans)-isomer | Homo sapiens (human) | EC50 | 1,000.0000 | 1 | 1 |
| L-2-aminoadipic acid | Homo sapiens (human) | EC50 | 3,000.0000 | 1 | 1 |
| 1-amino-1,3-dicarboxycyclopentane | Homo sapiens (human) | EC50 | 501.2500 | 4 | 4 |
| 1-amino-3-(phosphonomethylene)cyclobutane-1-carboxylic acid | Homo sapiens (human) | EC50 | 4.4000 | 1 | 1 |
| alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid | Homo sapiens (human) | EC50 | 3,000.0000 | 1 | 1 |
| alpha-amino-3-(hydroxy)-5-methyl-4-isoxazoleacetic acid | Homo sapiens (human) | EC50 | 1,000.0000 | 1 | 1 |
| 2-amino-4-phosphonobutyric acid | Homo sapiens (human) | EC50 | 0.3217 | 6 | 6 |
| eglumetad | Homo sapiens (human) | EC50 | 100.0000 | 1 | 1 |
| n-(3-chlorophenyl)picolinamide | Homo sapiens (human) | EC50 | 1.1240 | 4 | 4 |
| vu 0155041 | Homo sapiens (human) | EC50 | 0.7450 | 2 | 2 |
| vu0155094 | Homo sapiens (human) | EC50 | 3.3150 | 2 | 2 |
| upf 596 | Homo sapiens (human) | EC50 | 300.0000 | 1 | 1 |
| 1-amino-1,3-dicarboxycyclopentane, cis-(1s,3s)-isomer | Homo sapiens (human) | EC50 | 49.0000 | 2 | 2 |
| 1-aminocyclopentane-1,3,4-tricarboxylic acid | Homo sapiens (human) | EC50 | 5.3000 | 3 | 3 |
| ly 379268 | Homo sapiens (human) | EC50 | 21.1000 | 1 | 1 |
| 3,4-dicarboxyphenylglycine | Homo sapiens (human) | EC50 | 2.5800 | 2 | 2 |
| vu0361737 | Homo sapiens (human) | EC50 | 0.2400 | 2 | 2 |
| 5-methyl-n-(4-methylpyrimidin-2-yl)-4-(1h-pyrazol-4-yl)thiazol-2-amine | Homo sapiens (human) | EC50 | 0.0280 | 2 | 2 |
| lsp4-2022 | Homo sapiens (human) | EC50 | 0.1100 | 1 | 1 |
| vu0422288 | Homo sapiens (human) | EC50 | 0.1080 | 2 | 2 |
Drugs with Other Measurements
Ligands for glutamate receptors: design and therapeutic prospects.Journal of medicinal chemistry, , Jul-13, Volume: 43, Issue:14, 2000
1-Aminoindan-1,5-dicarboxylic acid: a novel antagonist at phospholipase C-linked metabotropic glutamate receptors.Journal of medicinal chemistry, , Sep-15, Volume: 38, Issue:19, 1995
Ligands for glutamate receptors: design and therapeutic prospects.Journal of medicinal chemistry, , Jul-13, Volume: 43, Issue:14, 2000
Synthesis and pharmacology of N-alkylated derivatives of the excitotoxin ibotenic acid.Bioorganic & medicinal chemistry letters, , Jun-16, Volume: 8, Issue:12, 1998
Ligands for glutamate receptors: design and therapeutic prospects.Journal of medicinal chemistry, , Jul-13, Volume: 43, Issue:14, 2000
1-Aminoindan-1,5-dicarboxylic acid: a novel antagonist at phospholipase C-linked metabotropic glutamate receptors.Journal of medicinal chemistry, , Sep-15, Volume: 38, Issue:19, 1995
Design, synthesis and biological evaluation of novel bicyclo[1.1.1]pentane-based omega-acidic amino acids as glutamate receptors ligands.Bioorganic & medicinal chemistry, , Jan-01, Volume: 17, Issue:1, 2009
Synthesis, molecular modeling studies, and preliminary pharmacological characterization of all possible 2-(2'-sulfonocyclopropyl)glycine stereoisomers as conformationally constrained L-homocysteic acid analogs.Journal of medicinal chemistry, , Sep-20, Volume: 50, Issue:19, 2007
(2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-methylcyclopropyl) glycine is a potent and selective metabotropic group 2 receptor agonist with anxiolytic properties.Journal of medicinal chemistry, , Aug-15, Volume: 45, Issue:17, 2002
Common and selective molecular determinants involved in metabotopic glutamate receptor agonist activity.Journal of medicinal chemistry, , Jul-18, Volume: 45, Issue:15, 2002
Ligands for glutamate receptors: design and therapeutic prospects.Journal of medicinal chemistry, , Jul-13, Volume: 43, Issue:14, 2000
Synthesis and biology of the conformationally restricted ACPD analogue, 2-aminobicyclo[2.1.1]hexane-2,5-dicarboxylic acid-I, a potent mGluR agonist.Journal of medicinal chemistry, , May-07, Volume: 41, Issue:10, 1998
A new highly selective metabotropic excitatory amino acid agonist: 2-amino-4-(3-hydroxy-5-methylisoxazol-4-yl)butyric acid.Journal of medicinal chemistry, , Aug-02, Volume: 39, Issue:16, 1996
Metabotropic glutamate receptors: novel targets for drug development.Journal of medicinal chemistry, , Apr-28, Volume: 38, Issue:9, 1995
Common and selective molecular determinants involved in metabotopic glutamate receptor agonist activity.Journal of medicinal chemistry, , Jul-18, Volume: 45, Issue:15, 2002
Ligands for glutamate receptors: design and therapeutic prospects.Journal of medicinal chemistry, , Jul-13, Volume: 43, Issue:14, 2000
Metabotropic glutamate receptors: novel targets for drug development.Journal of medicinal chemistry, , Apr-28, Volume: 38, Issue:9, 1995
Synthesis, molecular modeling and preliminary biological evaluation of 1-amino-3-phosphono-3-cyclopentene-1-carboxylic acid and 1-amino-3-phosphono-2-cyclopentene-1-carboxylic acid, two novel agonists of metabotropic glutamate receptors of group III.Bioorganic & medicinal chemistry letters, , Jul-03, Volume: 10, Issue:13, 2000
Metabotropic glutamate receptors: novel targets for drug development.Journal of medicinal chemistry, , Apr-28, Volume: 38, Issue:9, 1995
Ligands for glutamate receptors: design and therapeutic prospects.Journal of medicinal chemistry, , Jul-13, Volume: 43, Issue:14, 2000
A new highly selective metabotropic excitatory amino acid agonist: 2-amino-4-(3-hydroxy-5-methylisoxazol-4-yl)butyric acid.Journal of medicinal chemistry, , Aug-02, Volume: 39, Issue:16, 1996
(2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-methylcyclopropyl) glycine is a potent and selective metabotropic group 2 receptor agonist with anxiolytic properties.Journal of medicinal chemistry, , Aug-15, Volume: 45, Issue:17, 2002
Synthesis, molecular modeling and preliminary biological evaluation of 1-amino-3-phosphono-3-cyclopentene-1-carboxylic acid and 1-amino-3-phosphono-2-cyclopentene-1-carboxylic acid, two novel agonists of metabotropic glutamate receptors of group III.Bioorganic & medicinal chemistry letters, , Jul-03, Volume: 10, Issue:13, 2000
Ligands for glutamate receptors: design and therapeutic prospects.Journal of medicinal chemistry, , Jul-13, Volume: 43, Issue:14, 2000
Synthesis and biology of the conformationally restricted ACPD analogue, 2-aminobicyclo[2.1.1]hexane-2,5-dicarboxylic acid-I, a potent mGluR agonist.Journal of medicinal chemistry, , May-07, Volume: 41, Issue:10, 1998
Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids: new tools to discriminate between metabotropic glutamate receptor subtypes.Journal of medicinal chemistry, , Sep-12, Volume: 40, Issue:19, 1997
Metabotropic glutamate receptors: novel targets for drug development.Journal of medicinal chemistry, , Apr-28, Volume: 38, Issue:9, 1995
Increased Potency and Selectivity for Group III Metabotropic Glutamate Receptor Agonists Binding at Dual sites.Journal of medicinal chemistry, , 03-08, Volume: 61, Issue:5, 2018
Structural Basis for ( S)-3,4-Dicarboxyphenylglycine (DCPG) As a Potent and Subtype Selective Agonist of the mGluJournal of medicinal chemistry, , 11-21, Volume: 61, Issue:22, 2018
Design, synthesis and biological evaluation of novel bicyclo[1.1.1]pentane-based omega-acidic amino acids as glutamate receptors ligands.Bioorganic & medicinal chemistry, , Jan-01, Volume: 17, Issue:1, 2009
Synthesis and biological evaluation of 1-amino-2-phosphonomethylcyclopropanecarboxylic acids, new group III metabotropic glutamate receptor agonists.Journal of medicinal chemistry, , Jul-26, Volume: 50, Issue:15, 2007
Common and selective molecular determinants involved in metabotopic glutamate receptor agonist activity.Journal of medicinal chemistry, , Jul-18, Volume: 45, Issue:15, 2002
Synthesis, molecular modeling and preliminary biological evaluation of 1-amino-3-phosphono-3-cyclopentene-1-carboxylic acid and 1-amino-3-phosphono-2-cyclopentene-1-carboxylic acid, two novel agonists of metabotropic glutamate receptors of group III.Bioorganic & medicinal chemistry letters, , Jul-03, Volume: 10, Issue:13, 2000
Ligands for glutamate receptors: design and therapeutic prospects.Journal of medicinal chemistry, , Jul-13, Volume: 43, Issue:14, 2000
Metabotropic glutamate receptors: novel targets for drug development.Journal of medicinal chemistry, , Apr-28, Volume: 38, Issue:9, 1995
(2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-methylcyclopropyl) glycine is a potent and selective metabotropic group 2 receptor agonist with anxiolytic properties.Journal of medicinal chemistry, , Aug-15, Volume: 45, Issue:17, 2002
Ligands for glutamate receptors: design and therapeutic prospects.Journal of medicinal chemistry, , Jul-13, Volume: 43, Issue:14, 2000
Synthesis, pharmacological characterization, and molecular modeling of heterobicyclic amino acids related to (+)-2-aminobicyclo[3.1.0] hexane-2,6-dicarboxylic acid (LY354740): identification of two new potent, selective, and systemically active agonists fJournal of medicinal chemistry, , Mar-25, Volume: 42, Issue:6, 1999
Discovery of small-molecule compounds and natural products against Parkinson's disease: Pathological mechanism and structural modification.European journal of medicinal chemistry, , Jul-05, Volume: 237, 2022
Discovery and characterization of N-(1,3-dialkyl-1H-indazol-6-yl)-1H-pyrazolo[4,3-b]pyridin-3-amine scaffold as mGluBioorganic & medicinal chemistry letters, , 08-15, Volume: 28, Issue:15, 2018
Re-exploring the N-phenylpicolinamide derivatives to develop mGlu4 ligands with improved affinity and in vitro microsomal stability.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 25, Issue:18, 2015
Synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulators (PAMs).Journal of medicinal chemistry, , Jul-23, Volume: 52, Issue:14, 2009
Tricyclic thiazolopyrazole derivatives as metabotropic glutamate receptor 4 positive allosteric modulators.Journal of medicinal chemistry, , Jul-28, Volume: 54, Issue:14, 2011
Synthesis and SAR of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4).Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 19, Issue:17, 2009
Progress toward allosteric ligands of metabotropic glutamate 7 (mGlu7) receptor: 2008-present.MedChemComm, , Feb-01, Volume: 10, Issue:2, 2019
Discovery of VU6005649, a CNS Penetrant mGluACS medicinal chemistry letters, , Oct-12, Volume: 8, Issue:10, 2017
(2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-methylcyclopropyl) glycine is a potent and selective metabotropic group 2 receptor agonist with anxiolytic properties.Journal of medicinal chemistry, , Aug-15, Volume: 45, Issue:17, 2002
Ligands for glutamate receptors: design and therapeutic prospects.Journal of medicinal chemistry, , Jul-13, Volume: 43, Issue:14, 2000
Ligands for glutamate receptors: design and therapeutic prospects.Journal of medicinal chemistry, , Jul-13, Volume: 43, Issue:14, 2000
(S)-(+)-2-(3'-carboxybicyclo[1.1.1]pentyl)-glycine, a structurally new group I metabotropic glutamate receptor antagonist.Journal of medicinal chemistry, , Jul-19, Volume: 39, Issue:15, 1996
Synthesis and biology of the conformationally restricted ACPD analogue, 2-aminobicyclo[2.1.1]hexane-2,5-dicarboxylic acid-I, a potent mGluR agonist.Journal of medicinal chemistry, , May-07, Volume: 41, Issue:10, 1998
Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids: new tools to discriminate between metabotropic glutamate receptor subtypes.Journal of medicinal chemistry, , Sep-12, Volume: 40, Issue:19, 1997
Increased Potency and Selectivity for Group III Metabotropic Glutamate Receptor Agonists Binding at Dual sites.Journal of medicinal chemistry, , 03-08, Volume: 61, Issue:5, 2018
Synthesis, molecular modeling and preliminary biological evaluation of 1-amino-3-phosphono-3-cyclopentene-1-carboxylic acid and 1-amino-3-phosphono-2-cyclopentene-1-carboxylic acid, two novel agonists of metabotropic glutamate receptors of group III.Bioorganic & medicinal chemistry letters, , Jul-03, Volume: 10, Issue:13, 2000
Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids: new tools to discriminate between metabotropic glutamate receptor subtypes.Journal of medicinal chemistry, , Sep-12, Volume: 40, Issue:19, 1997
Ligands for glutamate receptors: design and therapeutic prospects.Journal of medicinal chemistry, , Jul-13, Volume: 43, Issue:14, 2000
2,3'-disubstituted-2-(2'-carboxycyclopropyl)glycines as potent and selective antagonists of metabotropic glutamate receptors.Bioorganic & medicinal chemistry letters, , Oct-20, Volume: 8, Issue:20, 1998
(2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-methylcyclopropyl) glycine is a potent and selective metabotropic group 2 receptor agonist with anxiolytic properties.Journal of medicinal chemistry, , Aug-15, Volume: 45, Issue:17, 2002
Ligands for glutamate receptors: design and therapeutic prospects.Journal of medicinal chemistry, , Jul-13, Volume: 43, Issue:14, 2000
Synthesis, pharmacological characterization, and molecular modeling of heterobicyclic amino acids related to (+)-2-aminobicyclo[3.1.0] hexane-2,6-dicarboxylic acid (LY354740): identification of two new potent, selective, and systemically active agonists fJournal of medicinal chemistry, , Mar-25, Volume: 42, Issue:6, 1999
Re-exploring the N-phenylpicolinamide derivatives to develop mGlu4 ligands with improved affinity and in vitro microsomal stability.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 25, Issue:18, 2015
Tricyclic thiazolopyrazole derivatives as metabotropic glutamate receptor 4 positive allosteric modulators.Journal of medicinal chemistry, , Jul-28, Volume: 54, Issue:14, 2011
Synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulators (PAMs).Journal of medicinal chemistry, , Jul-23, Volume: 52, Issue:14, 2009
Discovery of VU6005649, a CNS Penetrant mGluACS medicinal chemistry letters, , Oct-12, Volume: 8, Issue:10, 2017
Re-exploring the N-phenylpicolinamide derivatives to develop mGlu4 ligands with improved affinity and in vitro microsomal stability.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 25, Issue:18, 2015
Progress toward allosteric ligands of metabotropic glutamate 7 (mGlu7) receptor: 2008-present.MedChemComm, , Feb-01, Volume: 10, Issue:2, 2019
Discovery of VU6005649, a CNS Penetrant mGluACS medicinal chemistry letters, , Oct-12, Volume: 8, Issue:10, 2017
Enables
This protein enables 3 target(s):
| Target | Category | Definition |
|---|
| G protein-coupled receptor activity | molecular function | Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] |
| glutamate receptor activity | molecular function | Combining with glutamate and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:ai, GOC:signaling] |
| adenylate cyclase inhibiting G protein-coupled glutamate receptor activity | molecular function | Combining with glutamate and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex to inhibit downstream adenylate cyclase activity. [GOC:bf, GOC:dph] |
Located In
This protein is located in 3 target(s):
| Target | Category | Definition |
|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| cytoplasmic vesicle | cellular component | A vesicle found in the cytoplasm of a cell. [GOC:ai, GOC:mah, GOC:vesicles] |
| presynapse | cellular component | The part of a synapse that is part of the presynaptic cell. [GOC:dos] |
Active In
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
Involved In
This protein is involved in 7 target(s):
| Target | Category | Definition |
|---|
| adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway | biological process | An adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway initiated by glutamate binding to its receptor, and ending with the regulation of a downstream cellular process. [GOC:dph, GOC:mah, GOC:signaling, GOC:tb] |
| chemical synaptic transmission | biological process | The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. [GOC:jl, MeSH:D009435] |
| neurotransmitter secretion | biological process | The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium-regulated exocytosis during synaptic transmission. [GOC:dph] |
| positive regulation of MAPK cascade | biological process | Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade. [GOC:go_curators] |
| regulation of neuron apoptotic process | biological process | Any process that modulates the occurrence or rate of cell death by apoptotic process in neurons. [GOC:go_curators, GOC:mtg_apoptosis] |
| regulation of synaptic transmission, glutamatergic | biological process | Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate. [GOC:ai] |
| G protein-coupled glutamate receptor signaling pathway | biological process | A G protein-coupled receptor signaling pathway initiated by glutamate binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. [GOC:mah, GOC:signaling, PMID:9131252] |