Page last updated: 2024-10-28

halothane and Necrosis

halothane has been researched along with Necrosis in 149 studies

Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.

Research Excerpts

ExcerptRelevanceReference
"Foci of necrosis have been observed in the liver of 50% of enzyme-induced rats treated with halothane."7.66Hepatic necrosis in rats following halothane administration: protective effect of diethyldithiocarbamate. ( Eade, OE; Lucas, K; Millward-Sadler, GH; Mitchell, J; Wright, R, 1980)
"The effect of halothane anesthesia on myocardial necrosis resulting from coronary artery ligation was examined in 28 anesthetized mongrel dogs."7.66The effect of halothane anesthesia on myocardial necrosis, hemodynamic performance, and regional myocardial blood flow in dogs following coronary artery occlusion. ( Davis, RF; DeBoer, LW; Lowenstein, E; Maroko, PR; Rude, RE, 1983)
"8% enflurane, or 1% halothane in 21% oxygen (air) for two hours resulted in hepatic centrilobular necrosis."7.66Isoflurane and enflurane-induced hepatic necrosis in triiodothyronine-pretreated rats. ( Berman, ML; Holaday, DA; Kuhnert, L; Phythyon, JM, 1983)
"Administration of anesthetic doses of halothane to hyperthyroid male rats results in the development of hepatic necrosis."7.66Characterization of hyperthyroidism enhancement of halothane-induced hepatotoxicity. ( Berman, ML; Harbison, RD; James, RC; Smith, AC, 1983)
"Exposure of phenobarbital-pretreated male Sprague-Dawley rats to halothane, 1 per cent, for two hours under conditions of hypoxia (FIO2 0."7.66An animal model of halothane hepatotoxicity: roles of enzyme induction and hypoxia. ( Brown, BR; McLain, GE; Sipes, IG, 1979)
"Hepatic centrilobular necrosis developed in rats pretreated with triiodothyronine (T3) and then anesthetized with halothane, 1 per cent, for two hours at an ambient oxygen concentration."7.66Halothane-induced hepatic necrosis in triiodothyronine-pretreated rats. ( Berman, ML; Harbison, RD; Hoyle, P; Phythyon, JM; Wood, AJ; Wood, M, 1980)
"Liver necrosis and an increase of serum sorbitol dehydrogenase activity can be produced in rats by halothane anesthesia (1% v/v in oxygen) following pretreatment with polychlorinated biphenyls."7.66[Prevention by metyrapone of halothane induced liver necrosis in rats (author's transl)]. ( Krüger, R; Nastainczyk, W; Rendic, S; Ullrich, V, 1982)
"Analysis of data derived from 130 reports of jaundice occurring after anaesthesia with halothane showed a significant relation between the number of exposures to this anaesthetic and the rapidity with which jaundice develops after exposure."7.65Jaundice after repeated exposure to halothane: an analysis of Reports to the Committee on Safety of Medicines. ( Inman, WH; Mushin, WW, 1974)
"5 or 23 mmol/kg) and sacrificed 24 h after dosing exhibited liver toxicity."5.26A study of the mechanism of halothane-induced liver necrosis. Role of covalent binding of halothane metabolites to liver proteins in the rat. ( Rao, GS, 1977)
" We present a case report wherein a person who sustained avulsion injury to his left hand in an industrial accident, died due to, fulminant hepatitis, hepatic encephalopathy and acute renal failure, having undergone six operations under general anesthesia with halothane during his stay in the hospital."3.73Fulminant hepatic failure following halothane anaesthesia. ( Bhat, VJ; Kumar, GP; Sowdi, V, 2005)
"The liver of all rats given halothane (14% O(2)) had extensive centrilobular necrosis and denaturation."3.73Ca2+ cytochemical changes of hepatotoxicity caused by halothane and sevoflurane in enzyme-induced hypoxic rats. ( Li, Q; Liu, ZQ; Yang, LQ; Yu, WF; Zhou, MT, 2005)
"The basis for susceptibility to halothane-induced liver necrosis in guinea-pigs was examined."3.69Halothane-induced liver injury in guinea-pigs: importance of cytochrome P450 enzyme activity and hepatic blood flow. ( Farrell, GC; Field, J; Frost, L; Mahoney, J; Tapner, M; Weltman, M, 1996)
"In vivo covalent binding of halothane biotransformation-reactive intermediates to hepatic protein and lipid was examined in association with the subsequent development of hepatic necrosis in the guinea pig."3.68Covalent binding of oxidative biotransformation intermediates is associated with halothane hepatotoxicity in guinea pigs. ( Gandolfi, AJ; Hall, PD; Lind, RC, 1990)
"Exposure of guinea pigs to 1% halothane in air for 4 hr resulted in extensive centrizonal hepatic necrosis in 70% of animals examined 2 to 3 days later."3.67Altered hepatic calcium homeostasis in guinea pigs with halothane-induced hepatotoxicity. ( Bilous, M; Farrell, GC; Frost, L; Mahoney, J, 1988)
"A report is given on a 24 year old nurse, who developed two episodes of fever, chills and malaise with high serum enzyme levels and histologic proof of extensive centrolobular hepatic necrosis in association with vocational halothane exposure in the operating theatre."3.67[Centrolobular liver cell necroses following occupational halothane contact. Association with antibodies to halothane altered liver cell components]. ( Börsch, G; Müller, KM; Neuberger, J; Ricken, D; Schmidt, G, 1985)
"Foci of necrosis have been observed in the liver of 50% of enzyme-induced rats treated with halothane."3.66Hepatic necrosis in rats following halothane administration: protective effect of diethyldithiocarbamate. ( Eade, OE; Lucas, K; Millward-Sadler, GH; Mitchell, J; Wright, R, 1980)
"The effect of halothane anesthesia on myocardial necrosis resulting from coronary artery ligation was examined in 28 anesthetized mongrel dogs."3.66The effect of halothane anesthesia on myocardial necrosis, hemodynamic performance, and regional myocardial blood flow in dogs following coronary artery occlusion. ( Davis, RF; DeBoer, LW; Lowenstein, E; Maroko, PR; Rude, RE, 1983)
"Administration of anesthetic doses of halothane to hyperthyroid male rats results in the development of hepatic necrosis."3.66Characterization of hyperthyroidism enhancement of halothane-induced hepatotoxicity. ( Berman, ML; Harbison, RD; James, RC; Smith, AC, 1983)
"Liver necrosis and an increase of serum sorbitol dehydrogenase activity can be produced in rats by halothane anesthesia (1% v/v in oxygen) following pretreatment with polychlorinated biphenyls."3.66[Prevention by metyrapone of halothane induced liver necrosis in rats (author's transl)]. ( Krüger, R; Nastainczyk, W; Rendic, S; Ullrich, V, 1982)
"Exposure of phenobarbital-pretreated male Sprague-Dawley rats to halothane, 1 per cent, for two hours under conditions of hypoxia (FIO2 0."3.66An animal model of halothane hepatotoxicity: roles of enzyme induction and hypoxia. ( Brown, BR; McLain, GE; Sipes, IG, 1979)
"Hepatic centrilobular necrosis developed in rats pretreated with triiodothyronine (T3) and then anesthetized with halothane, 1 per cent, for two hours at an ambient oxygen concentration."3.66Halothane-induced hepatic necrosis in triiodothyronine-pretreated rats. ( Berman, ML; Harbison, RD; Hoyle, P; Phythyon, JM; Wood, AJ; Wood, M, 1980)
"8% enflurane, or 1% halothane in 21% oxygen (air) for two hours resulted in hepatic centrilobular necrosis."3.66Isoflurane and enflurane-induced hepatic necrosis in triiodothyronine-pretreated rats. ( Berman, ML; Holaday, DA; Kuhnert, L; Phythyon, JM, 1983)
"The aetiology of massive liver-cell necrosis which developed in 16 patients following halothane anaesthesia was investigated by means of new serological techniques."3.66Specific serological markers in the diagnosis of fulminant hepatic failure associated with halothane anaesthesia. ( Davis, M; Gimson, AE; Neuberger, J; Williams, R, 1983)
"Hepatic necrosis was induced in rats by a single exposure to 1 per cent halothane in oxygen following pretreatment with a single dose of Aroclor 1254, a polychlorinated biphenyl."3.65An animal model of hepatotoxicity associated with halothane anesthesia. ( Brown, BR; Sipes, IG, 1976)
"After long-term exhibition to halothane (up to 96 hours), centrolobular hepatic damage (fatty degeneration, necrobiosis and necrosis) developed in rats, proportionally to the number of anesthesias and shortening of the intervals."3.65[Liver-damaging action of halothane--an animal experiment study]. ( Barz, H; Wolf, R, 1975)
"Eight pregnant Sprague-Dawley rates were exposed to 10 ppm halothane 8 hours/day and 5 days/week throughout pregnancy."3.65Ultrastructural evidence of the hepatotoxic effect of halothane in rats following in-utero exposure. ( Chang, LW; Dudley, AW; Katz, J; Lee, YK, 1975)
"Extensive infarction of the liver, initially thought to be halothane hepatitis, is described."3.65Spontaneous hepatic artery thrombosis with infarction of the liver. ( Balint, JA; Buhac, I; OConnor, PJ, 1976)
"Analysis of data derived from 130 reports of jaundice occurring after anaesthesia with halothane showed a significant relation between the number of exposures to this anaesthetic and the rapidity with which jaundice develops after exposure."3.65Jaundice after repeated exposure to halothane: an analysis of Reports to the Committee on Safety of Medicines. ( Inman, WH; Mushin, WW, 1974)
"The chloroform-treated rats also developed renal tubular necrosis with large increases in plasma creatinine and urea nitrogen, which were completely ameliorated by DMSO."1.30Late dimethyl sulfoxide administration provides a protective action against chemically induced injury in both the liver and the kidney. ( Gandolfi, AJ; Lind, RC, 1997)
"Four groups received sham head trauma (surgical incision of the scalp but no trauma) and were treated with (A) nothing, (B) chronic ethanol (6% ethanol in drinking water for 40 days), (C) acute ethanol 1."1.30The influence of acute and chronic alcohol treatment on brain edema, cerebral infarct volume and neurological outcome following experimental head trauma in rats. ( Artru, AA; Donato, T; Lam, AM; Laohaprasit, V; Paez, A; Shapira, Y, 1997)
"Hepatic necrosis was also seen after halothane anesthesia even at ambient oxygen concentrations, although the degree of necrosis was much milder."1.27Potentiation of halothane hepatotoxicity by chronic ethanol administration in rat: an animal model of halothane hepatitis. ( Ebihara, Y; Ishii, H; Kato, S; Nagata, S; Okuno, F; Takagi, T; Takahashi, H; Tashiro, M; Tsuchiya, M; Yamauchi, H, 1983)
"5 or 23 mmol/kg) and sacrificed 24 h after dosing exhibited liver toxicity."1.26A study of the mechanism of halothane-induced liver necrosis. Role of covalent binding of halothane metabolites to liver proteins in the rat. ( Rao, GS, 1977)
"The evidence suggests that acute pancreatitis may at times complicate viral hepatitis."1.25The association of viral hepatitis and acute pancreatitis. ( Geokas, MC; Olsen, H; Rinderknecht, H; Swanson, V, 1972)

Research

Studies (149)

TimeframeStudies, this research(%)All Research%
pre-1990136 (91.28)18.7374
1990's11 (7.38)18.2507
2000's2 (1.34)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
CHADWICK, DA1
JENNINGS, RC1
SLATER, EM1
GIBSON, JM1
DYKES, MH2
WALZER, SG1
MINUCK, M1
SHERLOCK, S1
GREEN, KG1
MUNGAVIN, JM1
AFFOLTER, H1
HARTMANN, G1
KAPFHAMMER, V1
SCHEIDEGGER, S1
BALESTRA, L1
GIARDINA, B1
URSO, L1
DALMONTE, PR1
BRESCHI, F1
TURA, S1
GINGRICH, TF1
VIRTUE, RW1
HILSCHER, A1
Kumar, GP1
Bhat, VJ1
Sowdi, V1
Yu, WF1
Yang, LQ1
Zhou, MT1
Liu, ZQ1
Li, Q1
Babior, BM1
Davidson, CS2
Wibert, L1
Creutzfeldt, W1
Eger, W1
Nassr-Esfahani, H1
Eade, OE2
Millward-Sadler, GH1
Lucas, K1
Mitchell, J1
Wright, R2
Black, M1
Sinclair, M1
Venning, GR1
Plummer, JL2
Hall, PD4
Cousins, MJ5
Bastin, FN1
Ilsley, AH1
Davis, RF1
DeBoer, LW1
Rude, RE1
Lowenstein, E1
Maroko, PR1
Smith, AC2
Berman, ML3
James, RC1
Harbison, RD2
Takagi, T1
Ishii, H1
Takahashi, H1
Kato, S1
Okuno, F1
Ebihara, Y1
Yamauchi, H1
Nagata, S1
Tashiro, M1
Tsuchiya, M1
Gaunt, PS1
Meuten, DJ1
Pecquet-Goad, ME1
Nastainczyk, W1
Rendic, S1
Ullrich, V1
Krüger, R1
Neuberger, J3
Gimson, AE2
Davis, M2
Williams, R6
Kuhnert, L1
Phythyon, JM2
Holaday, DA1
Lewis, JH1
Zimmerman, HJ3
Ishak, KG1
Mullick, FG1
Knights, KM2
Gourlay, GK2
Hall, P1
Maddrey, WC2
Pohl, LR1
Gillette, JR1
Van Dyke, RA1
Wyke, RJ1
Canalese, JC1
Bauer, G1
Heidenreich, A1
Findor, J1
Bruch, E1
Schmee, E1
de Elizalde, S1
Ferraina, P1
Morel, C1
Mieli-Vergani, G1
Tredger, JM1
Friend, SC1
Wood, M1
Hoyle, P1
Wood, AJ1
Groom, S1
Checkley, S1
Crawford, B1
Lind, RC4
Gandolfi, AJ4
Hall, PM2
Farrell, GC2
Frost, L2
Tapner, M1
Field, J1
Weltman, M1
Mahoney, J2
Shapira, Y1
Lam, AM1
Paez, A1
Artru, AA1
Laohaprasit, V1
Donato, T1
Mezin, P1
Payen, JF1
Bosson, JL1
Brambilla, E1
Stieglitz, P1
Fukunaga, T1
Davies, P1
Zhang, L1
Hashida, Y1
Motoyama, EK1
Chisholm, M1
Hawksley, M1
Lloyd, B1
Moles, TM1
Edwards, JC1
GArdner, MJ1
Trowell, J1
Peto, R1
Mitchell, JR1
Potter, WZ1
Rao, GS2
Grumley, JO1
Boitnott, JK1
McLain, GE1
Sipes, IG2
Brown, BR2
Ross, WT1
Daggy, BP1
Cardell, RR1
Mazzia, VD1
Simon, AH1
Wills, EJ1
Walton, B2
Talbot, IC1
Gopinath, G1
Ford, EJ3
Wolf, R1
Barz, H1
Chang, LW2
Lee, YK2
Dudley, AW2
Katz, J2
Brase, A1
Emminger, E1
Bockslaff, H1
Bianchi, L1
De Groote, J1
Desmet, V1
Gedigk, P1
Korb, G1
Popper, H2
Poulsen, H1
Scheuer, PJ1
Schmid, M1
Thaler, H1
Wepler, W1
Sadove, MS1
Thomason, R1
Redlin, TA1
Katz, D1
OConnor, PJ1
Buhac, I1
Balint, JA1
Bird, GL1
Agardh, CD1
Smith, ML1
Siesjö, BK1
Lunam, CA1
Seki, S1
Mizoguchi, Y1
Saito, S1
Shiomi, S1
Sakagami, Y1
Sakaguchi, H1
Kuroki, T1
Harihara, S1
Kobayashi, K1
Monna, T1
Bilous, M1
Gibson, RA1
Roschlau, G1
Lumb, WV1
Grandy, JL1
Heath, RB1
Dunlop, CI1
Hodgson, DS1
Jong, HJ1
Ho, ST1
Wong, CS1
Hsu, JC1
Chang, CL1
Jenner, MA1
O'Brien, TD1
Raffe, MR1
Cox, VS1
Stevens, DL1
O'Leary, TP1
Grøntved, A1
Eriksen, S1
Gaba, DM1
Metz, S1
Maze, M1
Schmidt, G1
Börsch, G1
Ricken, D1
Müller, KM1
Gopinath, C2
Jones, RS2
Klinge, O1
Smith, JS1
Harrison, GG1
Mathieu, A1
DiPadua, D1
Mills, J1
Kahan, B1
Brierley, JB1
Miller, AA1
Sundell, B1
Brander, P1
Tammisto, T1
Naccarato, R1
Gritti, G1
Giunta, F1
Chiaramonte, M1
Valenti, F1
Leinweber, B1
Cüppers, M1
L'Allemand, H1
Gilbert, JP1
McPeek, B1
Gottlieb, LS1
Trey, C1
LaMont, JT1
McCaughey, W1
Clark, RB1
Jones, GL1
Greifenstein, FE1
Gardiol, D1
Lepore, MJ1
Qizilbash, AH1
Barth, ML1
Cornish, HH1
Simpson, BR2
Strunin, L2
Waalton, B1
Schatzki, PF1
Kay, S1
McGavic, JD1
Goertz, J1
Burnell, JM1
Runge, C1
Saunders, FC1
Thomas, ED1
Volwiler, W1
Nesvetov, AM1
Dovgiĭ, GM1
L'vova, TN1
Hussey, HH1
Inman, WH1
Mushin, WW1
Belcher, HV1
Remsberg, JR1
Cohen, EN1
Stenram, U1
Amstutz, HC1
Lurie, L1
Bullough, P1
Davis, JE1
Stenger, RJ1
Johnson, EA1
Geokas, MC1
Olsen, H1
Swanson, V1
Rinderknecht, H1
Owen, DR1
Schenken, JR1
Caravati, CM1
Hooker, TH1
Lempinen, M1
Collan, Y1
Sivula, A1
Merikallio, E1
Salmenkivi, K1
Paloheimo, M1
Turunen, MT1
Jokinen, EJ1
Ahlqvist, J1
Berglund, A1
Satler, J1
Voncina, J1
Lippman, PA1
Rivera, RA1
McAllister, HA1
Robinowitz, M1
Peters, RL1
Edmondson, HA1
Reynolds, TB1
Meister, JC1
Curpey, TJ1
Mäkelä, V1
Lähdesmäki, M1
Bog-Jensen, R1
Hansen, V1
Dordal, E1
Glagov, S1
Orlando, RA1
Platz, C1
Clauberg, G1
Schwesinger, G1
Pink, V1
Braune, R1
Celary, W1
Dentan, M1
Desmonts, JM1
Berthelot, P1
Robles, C1
Kelley, J1
Miller, RE1
Gronert, GA1
Schaner, PJ1
Gunther, RC1
Combes, B1
Lande, M1
Clot, C1
Vos, AK1
Neal, MJ1
Robson, JM1
DeBacker, LJ1
Longnecker, DS1
Babior, B1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Implication of Patient in the Making Ready of Recommendations for the Antivitamin K's Gestion in Case of Thrombosis Embolic Venous's Illness. Randomised Study for Clinical Validation.[NCT00227097]300 participants Observational2002-12-31Terminated
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

11 reviews available for halothane and Necrosis

ArticleYear
Drug induced liver disease.
    Postgraduate medical journal, 1983, Volume: 59 Suppl 4

    Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Halothane; Humans; Liver; Necrosis

1983
Drug-related acute and chronic hepatitis.
    Clinics in gastroenterology, 1980, Volume: 9, Issue:1

    Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Hypersen

1980
Drug metabolism in the production of liver injury.
    The Medical clinics of North America, 1975, Volume: 59, Issue:4

    Topics: Acetaminophen; Acetanilides; Alkylating Agents; Bromobenzenes; Chemical and Drug Induced Liver Injur

1975
Drug-induced chronic hepatitis and cirrhosis.
    Progress in liver diseases, 1979, Volume: 6

    Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Cholestasis; Drug-Related Side Effects and Adve

1979
Acute liver injury.
    Journal of clinical pathology. Supplement (Royal College of Pathologists), 1975, Volume: 9

    Topics: Acetaminophen; Acute Disease; Chemical and Drug Induced Liver Injury; Cholestasis; Halothane; Hepati

1975
Anaesthesia-related liver disease.
    Monographs in allergy, 1992, Volume: 30

    Topics: Anesthetics; Animals; Chemical and Drug Induced Liver Injury; Enflurane; Halothane; Humans; Incidenc

1992
[30 years of halothane--30 years of halothane hepatitis].
    Anaesthesiologie und Reanimation, 1987, Volume: 12, Issue:4

    Topics: Adult; Anesthesia, General; Chemical and Drug Induced Liver Injury; Child; Female; Halothane; Humans

1987
Halothane in the United States. An appraisal of the literature on "halothane hepatitis" and the American reaction to it.
    British journal of anaesthesia, 1972, Volume: 44, Issue:9

    Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Drug Hypers

1972
The effects of fluorinated anesthetics on the liver and kidneys.
    Annual review of medicine, 1974, Volume: 25

    Topics: Acute Kidney Injury; Adult; Anesthesia, Inhalation; Animals; Biotransformation; Chemical and Drug In

1974
Postoperative juandice.
    The Surgical clinics of North America, 1974, Volume: 54, Issue:3

    Topics: Aminosalicylic Acids; Anemia, Hemolytic; Bile Ducts; Bilirubin; Chemical and Drug Induced Liver Inju

1974
The halothane dilemma: a case for the defence.
    British medical journal, 1971, Oct-09, Volume: 4, Issue:5779

    Topics: Adult; Anesthesia, General; Antigens; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity;

1971

Trials

4 trials available for halothane and Necrosis

ArticleYear
Controlled prospective study of the effect on liver function of multiple exposures to halothane.
    Lancet (London, England), 1975, Apr-12, Volume: 1, Issue:7911

    Topics: Aged; Alanine Transaminase; Anesthesia, Inhalation; Anesthetics; Aspartate Aminotransferases; Biopsy

1975
Controlled trial of repeated halothane anaesthetics in patients with carcinoma of the uterine cervix treated with radium.
    Lancet (London, England), 1975, Apr-12, Volume: 1, Issue:7911

    Topics: Adult; Aged; Alanine Transaminase; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; C

1975
Prospective and retrospective searches for liver necrosis following halothane anesthesia. Serum enzyme study and case report.
    JAMA, 1966, Jan-17, Volume: 195, Issue:3

    Topics: Adult; Anesthesia, General; Chemical and Drug Induced Liver Injury; Clinical Enzyme Tests; Halothane

1966
Summary of the national Halothane Study. Possible association between halothane anesthesia and postoperative hepatic necrosis.
    JAMA, 1966, Sep-05, Volume: 197, Issue:10

    Topics: Adolescent; Adult; Aged; Anesthesia, Inhalation; Barbiturates; Cyclopropanes; Ethers; Female; Haloth

1966

Other Studies

134 other studies available for halothane and Necrosis

ArticleYear
MASSIVE HEPATIC NECROSIS ASSOCIATED WITH HALOTHANE ANESTHESIA.
    Lancet (London, England), 1964, Apr-11, Volume: 1, Issue:7337

    Topics: Anesthesia; Atropine; Barbiturates; Chemical and Drug Induced Liver Injury; Colonic Neoplasms; Halot

1964
POSTOPERATIVE HEPATIC NECROSIS. ITS INCIDENCE AND DIAGNOSTIC VALUE IN ASSOCIATION WITH THE ADMINISTRATION OF HALOTHANE.
    The New England journal of medicine, 1964, May-07, Volume: 270

    Topics: Chemical and Drug Induced Liver Injury; Cyclopropanes; Diagnosis, Differential; Geriatrics; Halothan

1964
MASSIVE HEPATIC NECROSIS ASSOCIATED WITH HALOTHANE ANAESTHESIA.
    Lancet (London, England), 1964, May-30, Volume: 1, Issue:7344

    Topics: Anesthesia; Chemical and Drug Induced Liver Injury; Halothane; Hepatitis; Massive Hepatic Necrosis;

1964
HALOTHANE AND THE LIVER.
    Proceedings of the Royal Society of Medicine, 1964, Volume: 57

    Topics: Chemical and Drug Induced Liver Injury; Chloroform; Halothane; Hepatitis; Jaundice; Liver Diseases;

1964
HALOTHANE AND THE LIVER: RETROSPECTIVE STUDIES.
    Proceedings of the Royal Society of Medicine, 1964, Volume: 57

    Topics: Chemical and Drug Induced Liver Injury; Halothane; Hepatitis A; Liver Diseases; Necrosis; Retrospect

1964
[ACUTE MASSIVE NECROSIS OF THE LIVER AFTER REPEATED HALOTHANE ANESTHESIA].
    Schweizerische medizinische Wochenschrift, 1964, Mar-14, Volume: 94

    Topics: Anesthesia; Chemical and Drug Induced Liver Injury; Halothane; Hepatitis A; Necrosis; Pharmacology;

1964
[COMPARATIVE EXPERIMENTAL STUDY OF THE HISTOLOGICAL CHANGES IN THE LIVER AND KIDNEY IN ACUTE POISONING BY CHLOROFORM, FLUOTHANE AND METHOCYFLURANE].
    Minerva anestesiologica, 1964, Volume: 30

    Topics: Anesthetics; Chemical and Drug Induced Liver Injury; Chloroform; Halothane; Hepatitis; Kidney; Kidne

1964
[FUNCTIONAL AND BIOPTIC STUDY OF THE LIVER IN PATIENTS EXPOSED TO FLUOTHANE ANESTHESIA].
    Minerva anestesiologica, 1964, Volume: 30

    Topics: Alanine Transaminase; Alkaline Phosphatase; Anesthesia; Aspartate Aminotransferases; Chemical and Dr

1964
POSTOPERATIVE LIVER DAMAGE: IS ANESTHESIA INVOLVED?
    Surgery, 1965, Volume: 57

    Topics: Anesthesia; Anesthetics; Chemical and Drug Induced Liver Injury; Geriatrics; Halogens; Halothane; He

1965
[ONCE AGAIN: ACUTE MASSIVE NECROSIS OF THE LIVER AFTER HALOTHANE ANESTHESIA].
    Schweizerische medizinische Wochenschrift, 1965, Jan-23, Volume: 95

    Topics: Anesthesia; Halothane; Liver Diseases; Necrosis; Toxicology

1965
Fulminant hepatic failure following halothane anaesthesia.
    Journal of clinical forensic medicine, 2005, Volume: 12, Issue:5

    Topics: Acute Kidney Injury; Adult; Anesthetics, Inhalation; Forensic Pathology; Halothane; Hand Injuries; H

2005
Ca2+ cytochemical changes of hepatotoxicity caused by halothane and sevoflurane in enzyme-induced hypoxic rats.
    World journal of gastroenterology, 2005, Aug-28, Volume: 11, Issue:32

    Topics: Alanine Transaminase; Anesthetics, Inhalation; Animals; Calcium; Chemical and Drug Induced Liver Inj

2005
Postoperative massive liver necrosis. A clinical and pathological study.
    The New England journal of medicine, 1967, Mar-23, Volume: 276, Issue:12

    Topics: Cardiovascular Diseases; Halothane; Hepatitis; Humans; In Vitro Techniques; Liver Diseases; Necrosis

1967
[Recurrent jaundice with fatal liver necrosis after halothane anesthesia performances].
    Deutsche medizinische Wochenschrift (1946), 1967, Mar-31, Volume: 92, Issue:13

    Topics: Anesthesia, General; Gastrectomy; Halothane; Humans; Jaundice; Liver Diseases; Male; Middle Aged; Ne

1967
[Fluothane damage of the stressed liver].
    Medicina et pharmacologia experimentalis. International journal of experimental medicine, 1967, Volume: 16, Issue:6

    Topics: Alcohols; Anesthesia; Animals; Chemical and Drug Induced Liver Injury; Halothane; Liver; Male; Necro

1967
Hepatic necrosis in rats following halothane administration: protective effect of diethyldithiocarbamate.
    Scandinavian journal of gastroenterology, 1980, Volume: 15, Issue:7

    Topics: Anesthesia, Inhalation; Animals; Chemical and Drug Induced Liver Injury; Ditiocarb; Halothane; Liver

1980
Does halothane cause liver necrosis.
    British medical journal (Clinical research ed.), 1983, Mar-12, Volume: 286, Issue:6368

    Topics: Chemical and Drug Induced Liver Injury; Halothane; Humans; Liver; Necrosis

1983
Does halothane cause liver necrosis?
    British medical journal (Clinical research ed.), 1983, Apr-09, Volume: 286, Issue:6372

    Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Halothane; Humans; Necrosis

1983
Hepatic injury in rats due to prolonged sub-anaesthetic halothane exposure.
    Acta pharmacologica et toxicologica, 1983, Volume: 53, Issue:1

    Topics: Aerosols; Alanine Transaminase; Animals; Body Weight; Female; Halothane; Liver; Liver Regeneration;

1983
The effect of halothane anesthesia on myocardial necrosis, hemodynamic performance, and regional myocardial blood flow in dogs following coronary artery occlusion.
    Anesthesiology, 1983, Volume: 59, Issue:5

    Topics: Anesthesia, Inhalation; Animals; Coronary Circulation; Coronary Disease; Dogs; Female; Halothane; He

1983
Characterization of hyperthyroidism enhancement of halothane-induced hepatotoxicity.
    Biochemical pharmacology, 1983, Dec-01, Volume: 32, Issue:23

    Topics: Alanine Transaminase; Animals; Biotransformation; Bromobenzenes; Chemical and Drug Induced Liver Inj

1983
Potentiation of halothane hepatotoxicity by chronic ethanol administration in rat: an animal model of halothane hepatitis.
    Pharmacology, biochemistry, and behavior, 1983, Volume: 18 Suppl 1

    Topics: Alcoholism; Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Drug Synergism;

1983
Hepatic necrosis associated with use of halothane in a dog.
    Journal of the American Veterinary Medical Association, 1984, Feb-15, Volume: 184, Issue:4

    Topics: Anesthesia, General; Animals; Chemical and Drug Induced Liver Injury; Dog Diseases; Dogs; Halothane;

1984
[Prevention by metyrapone of halothane induced liver necrosis in rats (author's transl)].
    Der Anaesthesist, 1982, Volume: 31, Issue:4

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Halothane; L-Iditol

1982
Specific serological markers in the diagnosis of fulminant hepatic failure associated with halothane anaesthesia.
    British journal of anaesthesia, 1983, Volume: 55, Issue:1

    Topics: Acute Disease; Adolescent; Adult; Aged; Anesthesia, Inhalation; Antibodies; Chemical and Drug Induce

1983
Isoflurane and enflurane-induced hepatic necrosis in triiodothyronine-pretreated rats.
    Anesthesiology, 1983, Volume: 58, Issue:1

    Topics: Animals; Body Weight; Chemical and Drug Induced Liver Injury; Eating; Enflurane; Halothane; Hyperthy

1983
Enflurane hepatotoxicity. A clinicopathologic study of 24 cases.
    Annals of internal medicine, 1983, Volume: 98, Issue:6

    Topics: Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; Enflurane; Female; Halothane; Human

1983
The predictive value of changes in antipyrine pharmacokinetics in halothane and paracetamol induced hepatic necrosis in rats.
    Research communications in chemical pathology and pharmacology, 1983, Volume: 40, Issue:2

    Topics: Acetaminophen; Animals; Antipyrine; Chemical and Drug Induced Liver Injury; Half-Life; Halothane; Ki

1983
A perspective on halothane-induced hepatotoxicity.
    Anesthesia and analgesia, 1982, Volume: 61, Issue:10

    Topics: Animals; Chemical and Drug Induced Liver Injury; Halothane; Humans; Liver; Necrosis; Rats

1982
Hepatic centrilobular necrosis in rats after exposure to halothane, enflurane, or isoflurane.
    Anesthesia and analgesia, 1982, Volume: 61, Issue:10

    Topics: Animals; Chemical and Drug Induced Liver Injury; Enflurane; Glutathione; Halothane; Isoflurane; Live

1982
Bacteraemia in patients with fulminant hepatic failure.
    Liver, 1982, Volume: 2, Issue:1

    Topics: Acetaminophen; Adolescent; Adult; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; H

1982
[Indication for halothane anesthesia].
    Acta medicinae legalis et socialis, 1982, Volume: 32

    Topics: Adult; Anesthesia, General; Chemical and Drug Induced Liver Injury; Ear, Middle; Halothane; Humans;

1982
[Hepatic lesion caused by halogenated anesthetics].
    Acta gastroenterologica Latinoamericana, 1982, Volume: 12, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Enflurane; Halothane; Humans; Liver; Male; Middle Aged; Necr

1982
Oxidative metabolism of halothane in the production of altered hepatocyte membrane antigens in acute halothane-induced hepatic necrosis.
    Gut, 1981, Volume: 22, Issue:8

    Topics: Animals; Antigens, Surface; Chemical and Drug Induced Liver Injury; Cytotoxicity, Immunologic; Femal

1981
Postanesthetic myonecrosis in horses.
    The Canadian veterinary journal = La revue veterinaire canadienne, 1981, Volume: 22, Issue:12

    Topics: Anesthesia; Animals; Calcium Metabolism Disorders; Halothane; Horse Diseases; Horses; Male; Muscles;

1981
Halothane-induced hepatic necrosis in triiodothyronine-pretreated rats.
    Anesthesiology, 1980, Volume: 52, Issue:6

    Topics: Alanine Transaminase; Animals; Body Weight; Chemical and Drug Induced Liver Injury; Cytochrome P-450

1980
Hepatic necrosis associated with halothane anesthesia in an alpaca.
    The Canadian veterinary journal = La revue veterinaire canadienne, 1995, Volume: 36, Issue:1

    Topics: Anesthesia, Inhalation; Animals; Camelids, New World; Chemical and Drug Induced Liver Injury; Haloth

1995
A model for fatal halothane hepatitis in the guinea pig.
    Anesthesiology, 1994, Volume: 81, Issue:2

    Topics: Animals; Buthionine Sulfoximine; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Glu

1994
Halothane-induced liver injury in guinea-pigs: importance of cytochrome P450 enzyme activity and hepatic blood flow.
    Journal of gastroenterology and hepatology, 1996, Volume: 11, Issue:6

    Topics: Animals; Arteries; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Fomepizole; Genetic Pred

1996
Late dimethyl sulfoxide administration provides a protective action against chemically induced injury in both the liver and the kidney.
    Toxicology and applied pharmacology, 1997, Volume: 142, Issue:1

    Topics: Administration, Inhalation; Administration, Oral; Alanine Transaminase; Allyl Compounds; Animals; Bi

1997
The influence of acute and chronic alcohol treatment on brain edema, cerebral infarct volume and neurological outcome following experimental head trauma in rats.
    Journal of neurosurgical anesthesiology, 1997, Volume: 9, Issue:2

    Topics: Administration, Oral; Alcoholism; Anesthesia, General; Animals; Brain; Brain Edema; Cerebral Hemorrh

1997
Histological support for the difference between malignant hyperthermia susceptible (MHS), equivocal (MHE) and negative (MHN) muscle biopsies.
    British journal of anaesthesia, 1997, Volume: 79, Issue:3

    Topics: Adolescent; Adult; Aged; Anesthetics, Inhalation; Atrophy; Biopsy; Disease Susceptibility; Female; H

1997
Prolonged high intermittent positive-pressure ventilation induces airway remodeling and reactivity in young rats.
    The American journal of physiology, 1998, Volume: 275, Issue:3

    Topics: Animals; Carbachol; Fibrosis; Halothane; Hyperoxia; In Vitro Techniques; Inflammation; Intermittent

1998
Extrahepatic tissue distribution, covalent binding, and toxicity of halothane in control and phenobarbital-pretreated rats.
    Pharmacology and therapeutics in dentistry, 1978, Volume: 3, Issue:2-4

    Topics: Animals; Chemical and Drug Induced Liver Injury; Halothane; Kidney; Liver; Lung; Male; Necrosis; Phe

1978
An animal model of halothane hepatotoxicity: roles of enzyme induction and hypoxia.
    Anesthesiology, 1979, Volume: 51, Issue:4

    Topics: Alanine Transaminase; Anesthesia, Inhalation; Animals; Chemical and Drug Induced Liver Injury; Cytoc

1979
Hepatic necrosis caused by halothane and hypoxia in phenobarbital-treated rats.
    Anesthesiology, 1979, Volume: 51, Issue:4

    Topics: Anesthesia, Inhalation; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Sys

1979
Liver failure associated with halothane.
    Legal medicine annual, 1977

    Topics: Adult; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Drug Labeling; Female; Haloth

1977
A morphologic study of unexplained hepatitis following halothane anesthesia.
    The American journal of pathology, 1978, Volume: 91, Issue:1

    Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Endoplasmic Reticulum; Female; Halothane; Human

1978
A study of the mechanism of halothane-induced liver necrosis. Role of covalent binding of halothane metabolites to liver proteins in the rat.
    Journal of medicinal chemistry, 1977, Volume: 20, Issue:2

    Topics: Alanine Transaminase; Animals; DNA; Drug Interactions; Halothane; In Vitro Techniques; Lipid Metabol

1977
The influence of hepatic microsomal amidopyrine demethylase activity on halothane hepatotoxicity in the horse.
    The Journal of pathology, 1976, Volume: 119, Issue:2

    Topics: Aminopyrine N-Demethylase; Animals; Carbon Disulfide; Chemical and Drug Induced Liver Injury; Chlorp

1976
An animal model of hepatotoxicity associated with halothane anesthesia.
    Anesthesiology, 1976, Volume: 45, Issue:6

    Topics: Anesthesia, Inhalation; Animals; Aroclors; Biotransformation; Chemical and Drug Induced Liver Injury

1976
[Liver-damaging action of halothane--an animal experiment study].
    Zeitschrift fur experimentelle Chirurgie, 1975, Volume: 8, Issue:4

    Topics: Animals; Bile Pigments; Cell Division; Chemical and Drug Induced Liver Injury; Dose-Response Relatio

1975
Ultrastructural evidence of the hepatotoxic effect of halothane in rats following in-utero exposure.
    Canadian Anaesthetists' Society journal, 1975, Volume: 22, Issue:3

    Topics: Animals; Animals, Newborn; Chemical and Drug Induced Liver Injury; Cytoplasm; Environmental Pollutan

1975
Liver disease caused by medicinal agents.
    The Medical clinics of North America, 1975, Volume: 59, Issue:4

    Topics: Adrenal Cortex Hormones; Analgesics; Chemical and Drug Induced Liver Injury; Cholestasis; Contracept

1975
Halothane on irradiated liver tissue.
    Strahlentherapie, 1975, Volume: 149, Issue:3

    Topics: Acute Disease; Animals; Chronic Disease; Dose-Response Relationship, Drug; Dose-Response Relationshi

1975
[Rules for the histological evaluation of drug-induced liver lesions].
    Deutsche medizinische Wochenschrift (1946), 1975, Aug-29, Volume: 100, Issue:35

    Topics: Biopsy; Chemical and Drug Induced Liver Injury; Chlorpromazine; Cholestasis; Contraceptives, Oral; F

1975
Postoperative fever and the halothane controversy.
    Comprehensive therapy, 1975, Volume: 1, Issue:1

    Topics: Anesthesia, General; Chemical and Drug Induced Liver Injury; Fever; Halothane; Humans; Malignant Hyp

1975
Spontaneous hepatic artery thrombosis with infarction of the liver.
    Gastroenterology, 1976, Volume: 70, Issue:4

    Topics: Aged; Amputation, Surgical; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Diagnosi

1976
Subanesthetic halothane is hepatotoxic in the guinea pig.
    Anesthesia and analgesia, 1992, Volume: 74, Issue:4

    Topics: Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, D

1992
The influence of hypothermia on hypoglycemia-induced brain damage in the rat.
    Acta neuropathologica, 1992, Volume: 83, Issue:4

    Topics: Animals; Blood Glucose; Body Temperature; Brain; Brain Diseases; Halothane; Hypoglycemia; Hypothermi

1992
Covalent binding of oxidative biotransformation intermediates is associated with halothane hepatotoxicity in guinea pigs.
    Anesthesiology, 1990, Volume: 73, Issue:6

    Topics: Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Halothane; Lipid Metabolism; Liv

1990
The pathology of halothane hepatotoxicity in a guinea-pig model: a comparison with human halothane hepatitis.
    British journal of experimental pathology, 1989, Volume: 70, Issue:5

    Topics: Alanine Transaminase; Anesthesia, Inhalation; Animals; Chemical and Drug Induced Liver Injury; Disea

1989
[A clinicopathological study of 11 patients with acute drug-induced hepatic failure].
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 1986, Volume: 83, Issue:12

    Topics: Acute Disease; Adult; Aged; Chemical and Drug Induced Liver Injury; Ethionamide; Female; Halothane;

1986
Altered hepatic calcium homeostasis in guinea pigs with halothane-induced hepatotoxicity.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 247, Issue:2

    Topics: Alanine Transaminase; Animals; Calcium; Cytochrome P-450 Enzyme System; Female; Guinea Pigs; Halotha

1988
Halothane induced hepatic necrosis in rats: the role of in vivo lipid peroxidation.
    Pharmacology & toxicology, 1988, Volume: 63, Issue:5

    Topics: Alanine Transaminase; Animals; Fatty Acids; Halothane; Lipid Metabolism; Lipid Peroxidation; Liver;

1988
Clinical report, "Hepatic necrosis following halothane anesthesia in goats," viewed as unacceptable.
    Journal of the American Veterinary Medical Association, 1987, May-01, Volume: 190, Issue:9

    Topics: Animals; Chemical and Drug Induced Liver Injury; Goats; Halothane; Liver Diseases; Necrosis

1987
[Unexplained fatal hepatic necrosis following halothane--a case report].
    Ma zui xue za zhi = Anaesthesiologica Sinica, 1987, Volume: 25, Issue:1

    Topics: Aged; Anesthesia; Chemical and Drug Induced Liver Injury; Halothane; Humans; Male; Necrosis

1987
Hepatic effects of repeated halothane anesthetics in the hypoxic rat model.
    Anesthesiology, 1987, Volume: 67, Issue:3

    Topics: Anesthesia, Inhalation; Animals; Halothane; Hypoxia; Liver; Male; Necrosis; Rats; Rats, Inbred F344;

1987
Hepatic necrosis following halothane anesthesia in goats.
    Journal of the American Veterinary Medical Association, 1986, Dec-15, Volume: 189, Issue:12

    Topics: Anesthesia, General; Animals; Female; Goats; Halothane; Liver; Necrosis

1986
[Local anesthetics with added adrenaline during halothane anesthesia. Assessment of the risk of necrosis and systemic side effects when these preparations are employed peripherally].
    Ugeskrift for laeger, 1987, Feb-02, Volume: 149, Issue:6

    Topics: Anesthesia, Inhalation; Anesthetics, Local; Epinephrine; Halothane; Humans; Lidocaine; Necrosis; Ris

1987
Postcountershock myocardial damage after pretreatment with adrenergic and calcium channel antagonists in halothane-anesthetized dogs.
    Anesthesiology, 1985, Volume: 62, Issue:5

    Topics: Anesthesia, Inhalation; Animals; Calcium Channel Blockers; Dogs; Electric Countershock; Female; Halo

1985
[Centrolobular liver cell necroses following occupational halothane contact. Association with antibodies to halothane altered liver cell components].
    Zeitschrift fur Gastroenterologie, 1985, Volume: 23, Issue:4

    Topics: Adult; Autoantibodies; Biopsy; Chemical and Drug Induced Liver Injury; Female; Halothane; Humans; Li

1985
The effect of the repeated administration of halothane on the liver of the horse.
    The Journal of pathology, 1970, Volume: 102, Issue:2

    Topics: Adenosine Triphosphatases; Alcohol Oxidoreductases; Alkaline Phosphatase; Animals; Arginase; Asparta

1970
[Morphology and etiology of halothane-induced liver lesions (author's transl)].
    Verhandlungen der Deutschen Gesellschaft fur Pathologie, 1972, Volume: 56

    Topics: Adult; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Child; Cholestasis; Fatty Liv

1972
The effects of multiple anaesthetics on the livers of rats subjected to microsomal enzyme induction. A preliminary report.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1973, May-12, Volume: 47, Issue:18

    Topics: Anesthetics; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Enzyme

1973
Experimental immunity to a metabolite of halothane and fluroxene: cutaneous delayed-type hypersensitivity.
    Anesthesiology, 1974, Volume: 40, Issue:4

    Topics: Albumins; Animals; Biotransformation; Cattle; Chemical and Drug Induced Liver Injury; Disease Models

1974
Fatal brain damage after dental anaesthesia. Its nature, etiology, and prevention.
    Lancet (London, England), 1966, Oct-22, Volume: 2, Issue:7469

    Topics: Adult; Anesthesia, Dental; Anesthesia, Inhalation; Brain Diseases; Halothane; Humans; Male; Methohex

1966
The effects of chloroform or halothane on horse liver in the early stage of ragwort poisoning.
    The Journal of pathology, 1972, Volume: 107, Issue:4

    Topics: Adenosine Triphosphatases; Alkaline Phosphatase; Animals; Arginase; Bilirubin; Biopsy; Chemical and

1972
Ultrastructural changes in the nervous system after chronic exposure to halothane.
    Experimental neurology, 1974, Volume: 45, Issue:2

    Topics: Animals; Brain Diseases; Cerebral Cortex; Chronic Disease; Endoplasmic Reticulum; Environmental Expo

1974
The spectrum of hepatotoxicity.
    Perspectives in biology and medicine, 1968,Autumn, Volume: 12, Issue:1

    Topics: Aminosalicylic Acids; Anti-Bacterial Agents; Antimetabolites; Benzene Derivatives; Carbon Tetrachlor

1968
Post-anesthetic tissue necrosis in experimental pedicle skin flaps.
    Scandinavian journal of plastic and reconstructive surgery, 1969, Volume: 3, Issue:2

    Topics: Acid-Base Equilibrium; Anesthetics; Animals; Blood Volume; Central Venous Pressure; Ethers; Graft vs

1969
Letter: Hepatic necrosis after enflurance anesthesia.
    JAMA, 1974, Apr-08, Volume: 228, Issue:2

    Topics: Anesthesia; Chemical and Drug Induced Liver Injury; Female; Halothane; Humans; Hydrocarbons, Halogen

1974
[Exchange transfusion in the treatment of acute hepatic insufficiency].
    Minerva chirurgica, 1974, Sep-30, Volume: 29, Issue:18

    Topics: Acute Disease; Adolescent; Adult; Child; Child, Preschool; Exchange Transfusion, Whole Blood; Fatty

1974
Editorial: Halothane and liver damage.
    British medical journal, 1974, Sep-07, Volume: 3, Issue:5931

    Topics: Anesthetics; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Halothane; Humans; Jaund

1974
Morphological results of the rat liver after the application of halothane and hypoxia.
    Acta hepato-gastroenterologica, 1974, Volume: 21, Issue:5

    Topics: Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Cholinesterases; Endop

1974
Halothane metabolism and the liver.
    The New Zealand medical journal, 1973, Volume: 77, Issue:490

    Topics: Anesthesia, General; Chemical and Drug Induced Liver Injury; Halothane; Humans; Liver; Necrosis; Ret

1973
A summary of the National Halothane Study.
    British journal of anaesthesia, 1972, Volume: 44, Issue:9

    Topics: Chemical and Drug Induced Liver Injury; Halothane; Humans; Necrosis; United States

1972
Anesthesia and hepatic necrosis.
    American journal of obstetrics and gynecology, 1972, Aug-15, Volume: 113, Issue:8

    Topics: Anesthetics; Chemical and Drug Induced Liver Injury; Cyclopropanes; Halothane; Humans; Necrosis

1972
[Early postoperative jaundice and peroperative liver diseases. Point of view of the anatomo-pathologist].
    Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1972, Sep-05, Volume: 61, Issue:36

    Topics: Anesthesia; Animals; Chemical and Drug Induced Liver Injury; Dogs; Halothane; Jaundice; Liver; Necro

1972
Fulminant hepatic failure.
    Postgraduate medicine, 1973, Volume: 53, Issue:1

    Topics: Adolescent; Adult; Age Factors; Aged; Enzymes; Exchange Transfusion, Whole Blood; Halothane; Hepatic

1973
Halothane hepatitis.
    Canadian Medical Association journal, 1973, Jan-20, Volume: 108, Issue:2

    Topics: Adult; Alkaline Phosphatase; Anesthesia, Inhalation; Aspartate Aminotransferases; Autopsy; Bilirubin

1973
The absence of effect of phenobarbital on halothane toxicity.
    Research communications in chemical pathology and pharmacology, 1973, Volume: 5, Issue:1

    Topics: Aerosols; Animals; Aspartate Aminotransferases; Body Weight; Halothane; Kidney; L-Lactate Dehydrogen

1973
Halothane hepatitis--fact or fallacy.
    Acta anaesthesiologica Belgica, 1973, Volume: 24, Issue:2

    Topics: Antibodies; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Drug Hypersensitivity;

1973
Ultrastructural pathology of a case of halothane hepatitis.
    The American journal of digestive diseases, 1973, Volume: 18, Issue:10

    Topics: Adult; Chemical and Drug Induced Liver Injury; Halothane; Humans; Kupffer Cells; Liver; Male; Micros

1973
Histological appearances in fulminant hepatic failure with reference to aetiology, time of survival and role of immunological processes.
    Digestion, 1973, Volume: 8, Issue:1

    Topics: Acetaminophen; Adolescent; Adult; Aged; Cell Nucleus; Chemical and Drug Induced Liver Injury; Haloth

1973
Acute hepatic failure treated by cross circulation.
    Archives of internal medicine, 1973, Volume: 132, Issue:4

    Topics: Acute Disease; Adult; Anesthesia; Aspartate Aminotransferases; Bilirubin; Blood Donors; Blood Platel

1973
[Malignant hyperthermia during anesthesia].
    Arkhiv patologii, 1973, Volume: 35, Issue:11

    Topics: Adult; Anesthesia, Endotracheal; Animals; Autopsy; Brain Edema; Chick Embryo; Halothane; Hand; Heart

1973
Editorial: Fulminant hepatic failure.
    JAMA, 1973, Dec-03, Volume: 226, Issue:10

    Topics: Age Factors; Aged; Anesthesia; Calcium; Chemical and Drug Induced Liver Injury; Exchange Transfusion

1973
Jaundice after repeated exposure to halothane: an analysis of Reports to the Committee on Safety of Medicines.
    British medical journal, 1974, Jan-05, Volume: 1, Issue:5896

    Topics: Acute Disease; Adolescent; Adult; Age Factors; Aged; Anesthesia, Inhalation; England; Female; Haloth

1974
Halothane anesthesia, hepatic necrosis, and death: report of a case.
    Military medicine, 1967, Volume: 132, Issue:7

    Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Female; Halothane; Humans; Middle Ag

1967
The biotransformation of halothane.
    Annals of the Royal College of Surgeons of England, 1971, Volume: 48, Issue:2

    Topics: Animals; Autoradiography; Biotransformation; Carbon Isotopes; Chemical and Drug Induced Liver Injury

1971
Fatal hepatic necrosis and halothane.
    British medical journal, 1972, Jan-29, Volume: 1, Issue:5795

    Topics: Chemical and Drug Induced Liver Injury; Female; Halothane; Humans; Middle Aged; Necrosis

1972
Skeletal fixation with self-curing polymethyl methacrylate. A report of 23 canine total hip replacements.
    Clinical orthopaedics and related research, 1972, Volume: 84

    Topics: Acetabulum; Acrylic Resins; Anesthesia, Inhalation; Animals; Bone Development; Bone Resorption; Dogs

1972
Fatal hepatic necrosis associated with halothane anesthesia.
    American journal of obstetrics and gynecology, 1972, Apr-01, Volume: 112, Issue:7

    Topics: Adult; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Female; Halothane; Hepatitis;

1972
Effects of phenobarbital pretreatment on the response of rat liver to halothane administration.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1972, Volume: 140, Issue:4

    Topics: Anesthesia, General; Animals; Chemical and Drug Induced Liver Injury; Cytochromes; Enzyme Induction;

1972
The association of viral hepatitis and acute pancreatitis.
    California medicine, 1972, Volume: 117, Issue:3

    Topics: Adult; Aged; Autolysis; Autopsy; Child, Preschool; Female; Halothane; Hepatitis A; Humans; Liver Dis

1972
Halothane hepatitis--an unsettled issue.
    The Nebraska medical journal, 1972, Volume: 57, Issue:10

    Topics: Aged; Chemical and Drug Induced Liver Injury; Female; Halothane; Humans; Male; Middle Aged; Necrosis

1972
Halothane hepatitis.
    British medical journal, 1971, Jul-10, Volume: 3, Issue:5766

    Topics: Chemical and Drug Induced Liver Injury; Halothane; Hepatitis A; Humans; Necrosis

1971
Acute massive hepatic necrosis with fatal liver failure.
    The American journal of digestive diseases, 1971, Volume: 16, Issue:9

    Topics: Acute Disease; Adolescent; Adult; Aged; Anticonvulsants; Antitubercular Agents; Azathioprine; Blood

1971
Pig-liver perfusion. Extracorporeal pig-liver perfusion in a patient with acute hepatic failure.
    Scandinavian journal of gastroenterology, 1971, Volume: 6, Issue:5

    Topics: Adult; Ammonia; Anesthesia, Inhalation; Animals; Autopsy; Bilirubin; Biopsy; Embolism; Female; Halot

1971
[Jaundice after halothane anesthesia].
    Nordisk medicin, 1971, Oct-28, Volume: 85, Issue:43

    Topics: Adult; Anesthesia; Aspartate Aminotransferases; Bilirubin; Body Temperature; Chemical and Drug Induc

1971
Fatal liver necrosis after repeated halothane anesthesia.
    Acta medica Iugoslavica, 1971, Volume: 25, Issue:1

    Topics: Anesthesia; Chemical and Drug Induced Liver Injury; Halothane; Humans; Intestinal Obstruction; Middl

1971
Halothane anesthesia and postoperative liver necrosis.
    The Journal of the American Osteopathic Association, 1968, Volume: 68, Issue:1

    Topics: Anesthesia, General; Chemical and Drug Induced Liver Injury; Cholecystectomy; Female; Halothane; Hum

1968
Fulminant hepatic necrosis following halothane anesthesia.
    The Medical annals of the District of Columbia, 1970, Volume: 39, Issue:7

    Topics: Acute Disease; Chemical and Drug Induced Liver Injury; Female; Halothane; Humans; Middle Aged; Necro

1970
Hepatic necrosis associated with halothane anesthesia.
    The American journal of medicine, 1969, Volume: 47, Issue:5

    Topics: Anesthesia; Autopsy; Biopsy; Chemical and Drug Induced Liver Injury; Cholestasis; Collagen; Connecti

1969
Haemobilia associated with hepatic necrosis after halothane anaesthesia. A case report.
    Annales chirurgiae et gynaecologiae Fenniae, 1969, Volume: 58, Issue:2

    Topics: Anesthesia, Inhalation; Biliary Tract; Chemical and Drug Induced Liver Injury; Halothane; Hemorrhage

1969
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 10-1970.
    The New England journal of medicine, 1970, Mar-05, Volume: 282, Issue:10

    Topics: Aged; Autopsy; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Female; Halothane; H

1970
[Liver necrosis after halothane anesthesia].
    Ugeskrift for laeger, 1970, May-28, Volume: 132, Issue:22

    Topics: Anesthesia, Inhalation; Halothane; Humans; Liver; Male; Middle Aged; Necrosis

1970
Liver necrosis after repeated fluothane anaesthesia. Cause or coincidence?
    Acta anaesthesiologica Scandinavica, 1970, Volume: 14, Issue:1

    Topics: Adolescent; Aged; Anesthesia, General; Biopsy; Chemical and Drug Induced Liver Injury; Female; Halot

1970
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 24-1970.
    The New England journal of medicine, 1970, Jun-04, Volume: 282, Issue:23

    Topics: Aged; Autopsy; Blood Coagulation Disorders; Chemical and Drug Induced Liver Injury; Diagnosis, Diffe

1970
Fatal halothane hepatitis with transient granulomas.
    The New England journal of medicine, 1970, 08-13, Volume: 283, Issue:7

    Topics: Adult; Anesthesia, Inhalation; Autopsy; Biopsy; Chemical and Drug Induced Liver Injury; Drug Hyperse

1970
[Studies of the effect of an inhalation anesthesia and surgery on the liver function with special reference to halothane. 1].
    Der Anaesthesist, 1970, Volume: 19, Issue:9

    Topics: Alanine Transaminase; Anesthesia, Inhalation; Animals; Aspartate Aminotransferases; Bilirubin; Chemi

1970
[Postoperative toxic liver disease].
    Zeitschrift fur arztliche Fortbildung, 1971, Mar-01, Volume: 65, Issue:5

    Topics: Aged; Autopsy; Chemical and Drug Induced Liver Injury; Cholecystectomy; Cholelithiasis; Female; Halo

1971
[Halothane hepatitis].
    La Presse medicale, 1971, Jun-05, Volume: 79, Issue:28

    Topics: Chemical and Drug Induced Liver Injury; Female; Halothane; Humans; Hypersensitivity, Delayed; Liver;

1971
[Halothane and hepatic necrosis].
    Gaceta medica de Mexico, 1967, Volume: 97, Issue:11

    Topics: Adult; Anesthesia, Endotracheal; Halothane; Humans; Liver Diseases; Male; Necrosis

1967
Halothane and liver injury.
    The Medical letter on drugs and therapeutics, 1968, Jan-26, Volume: 10, Issue:2

    Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Halothane; Humans; Liver; Liver Dise

1968
Hepatic necrosis following halothane anesthesia.
    The Alabama journal of medical sciences, 1968, Volume: 5, Issue:2

    Topics: Chemical and Drug Induced Liver Injury; Female; Halothane; Humans; Necrosis

1968
Massive hepatic necrosis following multiple exposures to halothane.
    The American journal of medicine, 1968, Volume: 45, Issue:4

    Topics: Aged; Brain; Diagnosis, Differential; Female; Halothane; Hemorrhage; Humans; Kidney; Kidney Diseases

1968
Multiple halothane anesthesia in the burn patient.
    JAMA, 1968, Sep-16, Volume: 205, Issue:12

    Topics: Adolescent; Adult; Aged; Alanine Transaminase; Anesthesia, Inhalation; Aspartate Aminotransferases;

1968
Halothane-induced liver damage--an entity.
    The New England journal of medicine, 1969, Mar-06, Volume: 280, Issue:10

    Topics: Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Halothane; Humans; Liver; Liver Disea

1969
[Halothane and liver toxicity].
    La Presse medicale, 1969, Mar-22, Volume: 77, Issue:14

    Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Chloroform; Fever; Halothane; Hepati

1969
[Acute liver cell necrosis].
    Nederlands tijdschrift voor geneeskunde, 1969, Jun-21, Volume: 113, Issue:25

    Topics: Adult; Barbiturates; Chemical and Drug Induced Liver Injury; Female; Halothane; Humans; Liver; Liver

1969
The analgesic and anaesthetic actions of tetrafluorobenzene.
    British journal of pharmacology and chemotherapy, 1966, Volume: 26, Issue:2

    Topics: Analgesics; Anesthesia, Inhalation; Anesthetics; Animals; Arrhythmias, Cardiac; Benzene; Blood Press

1966
Concerning hepatotoxicity of halothane.
    The New England journal of medicine, 1966, Dec-29, Volume: 275, Issue:26

    Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Halothane; Humans; Necrosis

1966