halothane and Necrosis studies

Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.

Research Excerpts

Excerpt	Relevance	Reference
"Foci of necrosis have been observed in the liver of 50% of enzyme-induced rats treated with halothane."	7.66	Hepatic necrosis in rats following halothane administration: protective effect of diethyldithiocarbamate. ( Eade, OE; Lucas, K; Millward-Sadler, GH; Mitchell, J; Wright, R, 1980)
"The effect of halothane anesthesia on myocardial necrosis resulting from coronary artery ligation was examined in 28 anesthetized mongrel dogs."	7.66	The effect of halothane anesthesia on myocardial necrosis, hemodynamic performance, and regional myocardial blood flow in dogs following coronary artery occlusion. ( Davis, RF; DeBoer, LW; Lowenstein, E; Maroko, PR; Rude, RE, 1983)
"8% enflurane, or 1% halothane in 21% oxygen (air) for two hours resulted in hepatic centrilobular necrosis."	7.66	Isoflurane and enflurane-induced hepatic necrosis in triiodothyronine-pretreated rats. ( Berman, ML; Holaday, DA; Kuhnert, L; Phythyon, JM, 1983)
"Administration of anesthetic doses of halothane to hyperthyroid male rats results in the development of hepatic necrosis."	7.66	Characterization of hyperthyroidism enhancement of halothane-induced hepatotoxicity. ( Berman, ML; Harbison, RD; James, RC; Smith, AC, 1983)
"Exposure of phenobarbital-pretreated male Sprague-Dawley rats to halothane, 1 per cent, for two hours under conditions of hypoxia (FIO2 0."	7.66	An animal model of halothane hepatotoxicity: roles of enzyme induction and hypoxia. ( Brown, BR; McLain, GE; Sipes, IG, 1979)
"Hepatic centrilobular necrosis developed in rats pretreated with triiodothyronine (T3) and then anesthetized with halothane, 1 per cent, for two hours at an ambient oxygen concentration."	7.66	Halothane-induced hepatic necrosis in triiodothyronine-pretreated rats. ( Berman, ML; Harbison, RD; Hoyle, P; Phythyon, JM; Wood, AJ; Wood, M, 1980)
"Liver necrosis and an increase of serum sorbitol dehydrogenase activity can be produced in rats by halothane anesthesia (1% v/v in oxygen) following pretreatment with polychlorinated biphenyls."	7.66	[Prevention by metyrapone of halothane induced liver necrosis in rats (author's transl)]. ( Krüger, R; Nastainczyk, W; Rendic, S; Ullrich, V, 1982)
"Analysis of data derived from 130 reports of jaundice occurring after anaesthesia with halothane showed a significant relation between the number of exposures to this anaesthetic and the rapidity with which jaundice develops after exposure."	7.65	Jaundice after repeated exposure to halothane: an analysis of Reports to the Committee on Safety of Medicines. ( Inman, WH; Mushin, WW, 1974)
"5 or 23 mmol/kg) and sacrificed 24 h after dosing exhibited liver toxicity."	5.26	A study of the mechanism of halothane-induced liver necrosis. Role of covalent binding of halothane metabolites to liver proteins in the rat. ( Rao, GS, 1977)
" We present a case report wherein a person who sustained avulsion injury to his left hand in an industrial accident, died due to, fulminant hepatitis, hepatic encephalopathy and acute renal failure, having undergone six operations under general anesthesia with halothane during his stay in the hospital."	3.73	Fulminant hepatic failure following halothane anaesthesia. ( Bhat, VJ; Kumar, GP; Sowdi, V, 2005)
"The liver of all rats given halothane (14% O(2)) had extensive centrilobular necrosis and denaturation."	3.73	Ca2+ cytochemical changes of hepatotoxicity caused by halothane and sevoflurane in enzyme-induced hypoxic rats. ( Li, Q; Liu, ZQ; Yang, LQ; Yu, WF; Zhou, MT, 2005)
"The basis for susceptibility to halothane-induced liver necrosis in guinea-pigs was examined."	3.69	Halothane-induced liver injury in guinea-pigs: importance of cytochrome P450 enzyme activity and hepatic blood flow. ( Farrell, GC; Field, J; Frost, L; Mahoney, J; Tapner, M; Weltman, M, 1996)
"In vivo covalent binding of halothane biotransformation-reactive intermediates to hepatic protein and lipid was examined in association with the subsequent development of hepatic necrosis in the guinea pig."	3.68	Covalent binding of oxidative biotransformation intermediates is associated with halothane hepatotoxicity in guinea pigs. ( Gandolfi, AJ; Hall, PD; Lind, RC, 1990)
"Exposure of guinea pigs to 1% halothane in air for 4 hr resulted in extensive centrizonal hepatic necrosis in 70% of animals examined 2 to 3 days later."	3.67	Altered hepatic calcium homeostasis in guinea pigs with halothane-induced hepatotoxicity. ( Bilous, M; Farrell, GC; Frost, L; Mahoney, J, 1988)
"A report is given on a 24 year old nurse, who developed two episodes of fever, chills and malaise with high serum enzyme levels and histologic proof of extensive centrolobular hepatic necrosis in association with vocational halothane exposure in the operating theatre."	3.67	[Centrolobular liver cell necroses following occupational halothane contact. Association with antibodies to halothane altered liver cell components]. ( Börsch, G; Müller, KM; Neuberger, J; Ricken, D; Schmidt, G, 1985)
"Foci of necrosis have been observed in the liver of 50% of enzyme-induced rats treated with halothane."	3.66	Hepatic necrosis in rats following halothane administration: protective effect of diethyldithiocarbamate. ( Eade, OE; Lucas, K; Millward-Sadler, GH; Mitchell, J; Wright, R, 1980)
"The effect of halothane anesthesia on myocardial necrosis resulting from coronary artery ligation was examined in 28 anesthetized mongrel dogs."	3.66	The effect of halothane anesthesia on myocardial necrosis, hemodynamic performance, and regional myocardial blood flow in dogs following coronary artery occlusion. ( Davis, RF; DeBoer, LW; Lowenstein, E; Maroko, PR; Rude, RE, 1983)
"Administration of anesthetic doses of halothane to hyperthyroid male rats results in the development of hepatic necrosis."	3.66	Characterization of hyperthyroidism enhancement of halothane-induced hepatotoxicity. ( Berman, ML; Harbison, RD; James, RC; Smith, AC, 1983)
"Liver necrosis and an increase of serum sorbitol dehydrogenase activity can be produced in rats by halothane anesthesia (1% v/v in oxygen) following pretreatment with polychlorinated biphenyls."	3.66	[Prevention by metyrapone of halothane induced liver necrosis in rats (author's transl)]. ( Krüger, R; Nastainczyk, W; Rendic, S; Ullrich, V, 1982)
"Exposure of phenobarbital-pretreated male Sprague-Dawley rats to halothane, 1 per cent, for two hours under conditions of hypoxia (FIO2 0."	3.66	An animal model of halothane hepatotoxicity: roles of enzyme induction and hypoxia. ( Brown, BR; McLain, GE; Sipes, IG, 1979)
"Hepatic centrilobular necrosis developed in rats pretreated with triiodothyronine (T3) and then anesthetized with halothane, 1 per cent, for two hours at an ambient oxygen concentration."	3.66	Halothane-induced hepatic necrosis in triiodothyronine-pretreated rats. ( Berman, ML; Harbison, RD; Hoyle, P; Phythyon, JM; Wood, AJ; Wood, M, 1980)
"8% enflurane, or 1% halothane in 21% oxygen (air) for two hours resulted in hepatic centrilobular necrosis."	3.66	Isoflurane and enflurane-induced hepatic necrosis in triiodothyronine-pretreated rats. ( Berman, ML; Holaday, DA; Kuhnert, L; Phythyon, JM, 1983)
"The aetiology of massive liver-cell necrosis which developed in 16 patients following halothane anaesthesia was investigated by means of new serological techniques."	3.66	Specific serological markers in the diagnosis of fulminant hepatic failure associated with halothane anaesthesia. ( Davis, M; Gimson, AE; Neuberger, J; Williams, R, 1983)
"Hepatic necrosis was induced in rats by a single exposure to 1 per cent halothane in oxygen following pretreatment with a single dose of Aroclor 1254, a polychlorinated biphenyl."	3.65	An animal model of hepatotoxicity associated with halothane anesthesia. ( Brown, BR; Sipes, IG, 1976)
"After long-term exhibition to halothane (up to 96 hours), centrolobular hepatic damage (fatty degeneration, necrobiosis and necrosis) developed in rats, proportionally to the number of anesthesias and shortening of the intervals."	3.65	[Liver-damaging action of halothane--an animal experiment study]. ( Barz, H; Wolf, R, 1975)
"Eight pregnant Sprague-Dawley rates were exposed to 10 ppm halothane 8 hours/day and 5 days/week throughout pregnancy."	3.65	Ultrastructural evidence of the hepatotoxic effect of halothane in rats following in-utero exposure. ( Chang, LW; Dudley, AW; Katz, J; Lee, YK, 1975)
"Extensive infarction of the liver, initially thought to be halothane hepatitis, is described."	3.65	Spontaneous hepatic artery thrombosis with infarction of the liver. ( Balint, JA; Buhac, I; OConnor, PJ, 1976)
"Analysis of data derived from 130 reports of jaundice occurring after anaesthesia with halothane showed a significant relation between the number of exposures to this anaesthetic and the rapidity with which jaundice develops after exposure."	3.65	Jaundice after repeated exposure to halothane: an analysis of Reports to the Committee on Safety of Medicines. ( Inman, WH; Mushin, WW, 1974)
"The chloroform-treated rats also developed renal tubular necrosis with large increases in plasma creatinine and urea nitrogen, which were completely ameliorated by DMSO."	1.30	Late dimethyl sulfoxide administration provides a protective action against chemically induced injury in both the liver and the kidney. ( Gandolfi, AJ; Lind, RC, 1997)
"Four groups received sham head trauma (surgical incision of the scalp but no trauma) and were treated with (A) nothing, (B) chronic ethanol (6% ethanol in drinking water for 40 days), (C) acute ethanol 1."	1.30	The influence of acute and chronic alcohol treatment on brain edema, cerebral infarct volume and neurological outcome following experimental head trauma in rats. ( Artru, AA; Donato, T; Lam, AM; Laohaprasit, V; Paez, A; Shapira, Y, 1997)
"Hepatic necrosis was also seen after halothane anesthesia even at ambient oxygen concentrations, although the degree of necrosis was much milder."	1.27	Potentiation of halothane hepatotoxicity by chronic ethanol administration in rat: an animal model of halothane hepatitis. ( Ebihara, Y; Ishii, H; Kato, S; Nagata, S; Okuno, F; Takagi, T; Takahashi, H; Tashiro, M; Tsuchiya, M; Yamauchi, H, 1983)
"5 or 23 mmol/kg) and sacrificed 24 h after dosing exhibited liver toxicity."	1.26	A study of the mechanism of halothane-induced liver necrosis. Role of covalent binding of halothane metabolites to liver proteins in the rat. ( Rao, GS, 1977)
"The evidence suggests that acute pancreatitis may at times complicate viral hepatitis."	1.25	The association of viral hepatitis and acute pancreatitis. ( Geokas, MC; Olsen, H; Rinderknecht, H; Swanson, V, 1972)

Timeframe	Studies, this research(%)	All Research%
pre-1990	136 (91.28)	18.7374
1990's	11 (7.38)	18.2507
2000's	2 (1.34)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Trial			Phase	Enrollment	Study Type	Start Date	Status
Implication of Patient in the Making Ready of Recommendations for the Antivitamin K's Gestion in Case of Thrombosis Embolic Venous's Illness. Randomised Study for Clinical Validation.[NCT00227097]				300 participants	Observational	2002-12-31	Terminated
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Drug induced liver disease. Postgraduate medical journal, 1983, Volume: 59 Suppl 4 Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Halothane; Humans; Liver; Necrosis	1983
Drug-related acute and chronic hepatitis. Clinics in gastroenterology, 1980, Volume: 9, Issue:1 Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Hypersen	1980
Drug metabolism in the production of liver injury. The Medical clinics of North America, 1975, Volume: 59, Issue:4 Topics: Acetaminophen; Acetanilides; Alkylating Agents; Bromobenzenes; Chemical and Drug Induced Liver Injur	1975
Drug-induced chronic hepatitis and cirrhosis. Progress in liver diseases, 1979, Volume: 6 Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Cholestasis; Drug-Related Side Effects and Adve	1979
Acute liver injury. Journal of clinical pathology. Supplement (Royal College of Pathologists), 1975, Volume: 9 Topics: Acetaminophen; Acute Disease; Chemical and Drug Induced Liver Injury; Cholestasis; Halothane; Hepati	1975
Anaesthesia-related liver disease. Monographs in allergy, 1992, Volume: 30 Topics: Anesthetics; Animals; Chemical and Drug Induced Liver Injury; Enflurane; Halothane; Humans; Incidenc	1992
[30 years of halothane--30 years of halothane hepatitis]. Anaesthesiologie und Reanimation, 1987, Volume: 12, Issue:4 Topics: Adult; Anesthesia, General; Chemical and Drug Induced Liver Injury; Child; Female; Halothane; Humans	1987
Halothane in the United States. An appraisal of the literature on "halothane hepatitis" and the American reaction to it. British journal of anaesthesia, 1972, Volume: 44, Issue:9 Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Drug Hypers	1972
The effects of fluorinated anesthetics on the liver and kidneys. Annual review of medicine, 1974, Volume: 25 Topics: Acute Kidney Injury; Adult; Anesthesia, Inhalation; Animals; Biotransformation; Chemical and Drug In	1974
Postoperative juandice. The Surgical clinics of North America, 1974, Volume: 54, Issue:3 Topics: Aminosalicylic Acids; Anemia, Hemolytic; Bile Ducts; Bilirubin; Chemical and Drug Induced Liver Inju	1974
The halothane dilemma: a case for the defence. British medical journal, 1971, Oct-09, Volume: 4, Issue:5779 Topics: Adult; Anesthesia, General; Antigens; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity;	1971

Article	Year
Controlled prospective study of the effect on liver function of multiple exposures to halothane. Lancet (London, England), 1975, Apr-12, Volume: 1, Issue:7911 Topics: Aged; Alanine Transaminase; Anesthesia, Inhalation; Anesthetics; Aspartate Aminotransferases; Biopsy	1975
Controlled trial of repeated halothane anaesthetics in patients with carcinoma of the uterine cervix treated with radium. Lancet (London, England), 1975, Apr-12, Volume: 1, Issue:7911 Topics: Adult; Aged; Alanine Transaminase; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; C	1975
Prospective and retrospective searches for liver necrosis following halothane anesthesia. Serum enzyme study and case report. JAMA, 1966, Jan-17, Volume: 195, Issue:3 Topics: Adult; Anesthesia, General; Chemical and Drug Induced Liver Injury; Clinical Enzyme Tests; Halothane	1966
Summary of the national Halothane Study. Possible association between halothane anesthesia and postoperative hepatic necrosis. JAMA, 1966, Sep-05, Volume: 197, Issue:10 Topics: Adolescent; Adult; Aged; Anesthesia, Inhalation; Barbiturates; Cyclopropanes; Ethers; Female; Haloth	1966

Article	Year
MASSIVE HEPATIC NECROSIS ASSOCIATED WITH HALOTHANE ANESTHESIA. Lancet (London, England), 1964, Apr-11, Volume: 1, Issue:7337 Topics: Anesthesia; Atropine; Barbiturates; Chemical and Drug Induced Liver Injury; Colonic Neoplasms; Halot	1964
POSTOPERATIVE HEPATIC NECROSIS. ITS INCIDENCE AND DIAGNOSTIC VALUE IN ASSOCIATION WITH THE ADMINISTRATION OF HALOTHANE. The New England journal of medicine, 1964, May-07, Volume: 270 Topics: Chemical and Drug Induced Liver Injury; Cyclopropanes; Diagnosis, Differential; Geriatrics; Halothan	1964
MASSIVE HEPATIC NECROSIS ASSOCIATED WITH HALOTHANE ANAESTHESIA. Lancet (London, England), 1964, May-30, Volume: 1, Issue:7344 Topics: Anesthesia; Chemical and Drug Induced Liver Injury; Halothane; Hepatitis; Massive Hepatic Necrosis;	1964
HALOTHANE AND THE LIVER. Proceedings of the Royal Society of Medicine, 1964, Volume: 57 Topics: Chemical and Drug Induced Liver Injury; Chloroform; Halothane; Hepatitis; Jaundice; Liver Diseases;	1964
HALOTHANE AND THE LIVER: RETROSPECTIVE STUDIES. Proceedings of the Royal Society of Medicine, 1964, Volume: 57 Topics: Chemical and Drug Induced Liver Injury; Halothane; Hepatitis A; Liver Diseases; Necrosis; Retrospect	1964
[ACUTE MASSIVE NECROSIS OF THE LIVER AFTER REPEATED HALOTHANE ANESTHESIA]. Schweizerische medizinische Wochenschrift, 1964, Mar-14, Volume: 94 Topics: Anesthesia; Chemical and Drug Induced Liver Injury; Halothane; Hepatitis A; Necrosis; Pharmacology;	1964
[COMPARATIVE EXPERIMENTAL STUDY OF THE HISTOLOGICAL CHANGES IN THE LIVER AND KIDNEY IN ACUTE POISONING BY CHLOROFORM, FLUOTHANE AND METHOCYFLURANE]. Minerva anestesiologica, 1964, Volume: 30 Topics: Anesthetics; Chemical and Drug Induced Liver Injury; Chloroform; Halothane; Hepatitis; Kidney; Kidne	1964
[FUNCTIONAL AND BIOPTIC STUDY OF THE LIVER IN PATIENTS EXPOSED TO FLUOTHANE ANESTHESIA]. Minerva anestesiologica, 1964, Volume: 30 Topics: Alanine Transaminase; Alkaline Phosphatase; Anesthesia; Aspartate Aminotransferases; Chemical and Dr	1964
POSTOPERATIVE LIVER DAMAGE: IS ANESTHESIA INVOLVED? Surgery, 1965, Volume: 57 Topics: Anesthesia; Anesthetics; Chemical and Drug Induced Liver Injury; Geriatrics; Halogens; Halothane; He	1965
[ONCE AGAIN: ACUTE MASSIVE NECROSIS OF THE LIVER AFTER HALOTHANE ANESTHESIA]. Schweizerische medizinische Wochenschrift, 1965, Jan-23, Volume: 95 Topics: Anesthesia; Halothane; Liver Diseases; Necrosis; Toxicology	1965
Fulminant hepatic failure following halothane anaesthesia. Journal of clinical forensic medicine, 2005, Volume: 12, Issue:5 Topics: Acute Kidney Injury; Adult; Anesthetics, Inhalation; Forensic Pathology; Halothane; Hand Injuries; H	2005
Ca2+ cytochemical changes of hepatotoxicity caused by halothane and sevoflurane in enzyme-induced hypoxic rats. World journal of gastroenterology, 2005, Aug-28, Volume: 11, Issue:32 Topics: Alanine Transaminase; Anesthetics, Inhalation; Animals; Calcium; Chemical and Drug Induced Liver Inj	2005
Postoperative massive liver necrosis. A clinical and pathological study. The New England journal of medicine, 1967, Mar-23, Volume: 276, Issue:12 Topics: Cardiovascular Diseases; Halothane; Hepatitis; Humans; In Vitro Techniques; Liver Diseases; Necrosis	1967
[Recurrent jaundice with fatal liver necrosis after halothane anesthesia performances]. Deutsche medizinische Wochenschrift (1946), 1967, Mar-31, Volume: 92, Issue:13 Topics: Anesthesia, General; Gastrectomy; Halothane; Humans; Jaundice; Liver Diseases; Male; Middle Aged; Ne	1967
[Fluothane damage of the stressed liver]. Medicina et pharmacologia experimentalis. International journal of experimental medicine, 1967, Volume: 16, Issue:6 Topics: Alcohols; Anesthesia; Animals; Chemical and Drug Induced Liver Injury; Halothane; Liver; Male; Necro	1967
Hepatic necrosis in rats following halothane administration: protective effect of diethyldithiocarbamate. Scandinavian journal of gastroenterology, 1980, Volume: 15, Issue:7 Topics: Anesthesia, Inhalation; Animals; Chemical and Drug Induced Liver Injury; Ditiocarb; Halothane; Liver	1980
Does halothane cause liver necrosis. British medical journal (Clinical research ed.), 1983, Mar-12, Volume: 286, Issue:6368 Topics: Chemical and Drug Induced Liver Injury; Halothane; Humans; Liver; Necrosis	1983
Does halothane cause liver necrosis? British medical journal (Clinical research ed.), 1983, Apr-09, Volume: 286, Issue:6372 Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Halothane; Humans; Necrosis	1983
Hepatic injury in rats due to prolonged sub-anaesthetic halothane exposure. Acta pharmacologica et toxicologica, 1983, Volume: 53, Issue:1 Topics: Aerosols; Alanine Transaminase; Animals; Body Weight; Female; Halothane; Liver; Liver Regeneration;	1983
The effect of halothane anesthesia on myocardial necrosis, hemodynamic performance, and regional myocardial blood flow in dogs following coronary artery occlusion. Anesthesiology, 1983, Volume: 59, Issue:5 Topics: Anesthesia, Inhalation; Animals; Coronary Circulation; Coronary Disease; Dogs; Female; Halothane; He	1983
Characterization of hyperthyroidism enhancement of halothane-induced hepatotoxicity. Biochemical pharmacology, 1983, Dec-01, Volume: 32, Issue:23 Topics: Alanine Transaminase; Animals; Biotransformation; Bromobenzenes; Chemical and Drug Induced Liver Inj	1983
Potentiation of halothane hepatotoxicity by chronic ethanol administration in rat: an animal model of halothane hepatitis. Pharmacology, biochemistry, and behavior, 1983, Volume: 18 Suppl 1 Topics: Alcoholism; Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Drug Synergism;	1983
Hepatic necrosis associated with use of halothane in a dog. Journal of the American Veterinary Medical Association, 1984, Feb-15, Volume: 184, Issue:4 Topics: Anesthesia, General; Animals; Chemical and Drug Induced Liver Injury; Dog Diseases; Dogs; Halothane;	1984
[Prevention by metyrapone of halothane induced liver necrosis in rats (author's transl)]. Der Anaesthesist, 1982, Volume: 31, Issue:4 Topics: Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Halothane; L-Iditol	1982
Specific serological markers in the diagnosis of fulminant hepatic failure associated with halothane anaesthesia. British journal of anaesthesia, 1983, Volume: 55, Issue:1 Topics: Acute Disease; Adolescent; Adult; Aged; Anesthesia, Inhalation; Antibodies; Chemical and Drug Induce	1983
Isoflurane and enflurane-induced hepatic necrosis in triiodothyronine-pretreated rats. Anesthesiology, 1983, Volume: 58, Issue:1 Topics: Animals; Body Weight; Chemical and Drug Induced Liver Injury; Eating; Enflurane; Halothane; Hyperthy	1983
Enflurane hepatotoxicity. A clinicopathologic study of 24 cases. Annals of internal medicine, 1983, Volume: 98, Issue:6 Topics: Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; Enflurane; Female; Halothane; Human	1983
The predictive value of changes in antipyrine pharmacokinetics in halothane and paracetamol induced hepatic necrosis in rats. Research communications in chemical pathology and pharmacology, 1983, Volume: 40, Issue:2 Topics: Acetaminophen; Animals; Antipyrine; Chemical and Drug Induced Liver Injury; Half-Life; Halothane; Ki	1983
A perspective on halothane-induced hepatotoxicity. Anesthesia and analgesia, 1982, Volume: 61, Issue:10 Topics: Animals; Chemical and Drug Induced Liver Injury; Halothane; Humans; Liver; Necrosis; Rats	1982
Hepatic centrilobular necrosis in rats after exposure to halothane, enflurane, or isoflurane. Anesthesia and analgesia, 1982, Volume: 61, Issue:10 Topics: Animals; Chemical and Drug Induced Liver Injury; Enflurane; Glutathione; Halothane; Isoflurane; Live	1982
Bacteraemia in patients with fulminant hepatic failure. Liver, 1982, Volume: 2, Issue:1 Topics: Acetaminophen; Adolescent; Adult; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; H	1982
[Indication for halothane anesthesia]. Acta medicinae legalis et socialis, 1982, Volume: 32 Topics: Adult; Anesthesia, General; Chemical and Drug Induced Liver Injury; Ear, Middle; Halothane; Humans;	1982
[Hepatic lesion caused by halogenated anesthetics]. Acta gastroenterologica Latinoamericana, 1982, Volume: 12, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Enflurane; Halothane; Humans; Liver; Male; Middle Aged; Necr	1982
Oxidative metabolism of halothane in the production of altered hepatocyte membrane antigens in acute halothane-induced hepatic necrosis. Gut, 1981, Volume: 22, Issue:8 Topics: Animals; Antigens, Surface; Chemical and Drug Induced Liver Injury; Cytotoxicity, Immunologic; Femal	1981
Postanesthetic myonecrosis in horses. The Canadian veterinary journal = La revue veterinaire canadienne, 1981, Volume: 22, Issue:12 Topics: Anesthesia; Animals; Calcium Metabolism Disorders; Halothane; Horse Diseases; Horses; Male; Muscles;	1981
Halothane-induced hepatic necrosis in triiodothyronine-pretreated rats. Anesthesiology, 1980, Volume: 52, Issue:6 Topics: Alanine Transaminase; Animals; Body Weight; Chemical and Drug Induced Liver Injury; Cytochrome P-450	1980
Hepatic necrosis associated with halothane anesthesia in an alpaca. The Canadian veterinary journal = La revue veterinaire canadienne, 1995, Volume: 36, Issue:1 Topics: Anesthesia, Inhalation; Animals; Camelids, New World; Chemical and Drug Induced Liver Injury; Haloth	1995
A model for fatal halothane hepatitis in the guinea pig. Anesthesiology, 1994, Volume: 81, Issue:2 Topics: Animals; Buthionine Sulfoximine; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Glu	1994
Halothane-induced liver injury in guinea-pigs: importance of cytochrome P450 enzyme activity and hepatic blood flow. Journal of gastroenterology and hepatology, 1996, Volume: 11, Issue:6 Topics: Animals; Arteries; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Fomepizole; Genetic Pred	1996
Late dimethyl sulfoxide administration provides a protective action against chemically induced injury in both the liver and the kidney. Toxicology and applied pharmacology, 1997, Volume: 142, Issue:1 Topics: Administration, Inhalation; Administration, Oral; Alanine Transaminase; Allyl Compounds; Animals; Bi	1997
The influence of acute and chronic alcohol treatment on brain edema, cerebral infarct volume and neurological outcome following experimental head trauma in rats. Journal of neurosurgical anesthesiology, 1997, Volume: 9, Issue:2 Topics: Administration, Oral; Alcoholism; Anesthesia, General; Animals; Brain; Brain Edema; Cerebral Hemorrh	1997
Histological support for the difference between malignant hyperthermia susceptible (MHS), equivocal (MHE) and negative (MHN) muscle biopsies. British journal of anaesthesia, 1997, Volume: 79, Issue:3 Topics: Adolescent; Adult; Aged; Anesthetics, Inhalation; Atrophy; Biopsy; Disease Susceptibility; Female; H	1997
Prolonged high intermittent positive-pressure ventilation induces airway remodeling and reactivity in young rats. The American journal of physiology, 1998, Volume: 275, Issue:3 Topics: Animals; Carbachol; Fibrosis; Halothane; Hyperoxia; In Vitro Techniques; Inflammation; Intermittent	1998
Extrahepatic tissue distribution, covalent binding, and toxicity of halothane in control and phenobarbital-pretreated rats. Pharmacology and therapeutics in dentistry, 1978, Volume: 3, Issue:2-4 Topics: Animals; Chemical and Drug Induced Liver Injury; Halothane; Kidney; Liver; Lung; Male; Necrosis; Phe	1978
An animal model of halothane hepatotoxicity: roles of enzyme induction and hypoxia. Anesthesiology, 1979, Volume: 51, Issue:4 Topics: Alanine Transaminase; Anesthesia, Inhalation; Animals; Chemical and Drug Induced Liver Injury; Cytoc	1979
Hepatic necrosis caused by halothane and hypoxia in phenobarbital-treated rats. Anesthesiology, 1979, Volume: 51, Issue:4 Topics: Anesthesia, Inhalation; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Sys	1979
Liver failure associated with halothane. Legal medicine annual, 1977 Topics: Adult; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Drug Labeling; Female; Haloth	1977
A morphologic study of unexplained hepatitis following halothane anesthesia. The American journal of pathology, 1978, Volume: 91, Issue:1 Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Endoplasmic Reticulum; Female; Halothane; Human	1978
A study of the mechanism of halothane-induced liver necrosis. Role of covalent binding of halothane metabolites to liver proteins in the rat. Journal of medicinal chemistry, 1977, Volume: 20, Issue:2 Topics: Alanine Transaminase; Animals; DNA; Drug Interactions; Halothane; In Vitro Techniques; Lipid Metabol	1977
The influence of hepatic microsomal amidopyrine demethylase activity on halothane hepatotoxicity in the horse. The Journal of pathology, 1976, Volume: 119, Issue:2 Topics: Aminopyrine N-Demethylase; Animals; Carbon Disulfide; Chemical and Drug Induced Liver Injury; Chlorp	1976
An animal model of hepatotoxicity associated with halothane anesthesia. Anesthesiology, 1976, Volume: 45, Issue:6 Topics: Anesthesia, Inhalation; Animals; Aroclors; Biotransformation; Chemical and Drug Induced Liver Injury	1976
[Liver-damaging action of halothane--an animal experiment study]. Zeitschrift fur experimentelle Chirurgie, 1975, Volume: 8, Issue:4 Topics: Animals; Bile Pigments; Cell Division; Chemical and Drug Induced Liver Injury; Dose-Response Relatio	1975
Ultrastructural evidence of the hepatotoxic effect of halothane in rats following in-utero exposure. Canadian Anaesthetists' Society journal, 1975, Volume: 22, Issue:3 Topics: Animals; Animals, Newborn; Chemical and Drug Induced Liver Injury; Cytoplasm; Environmental Pollutan	1975
Liver disease caused by medicinal agents. The Medical clinics of North America, 1975, Volume: 59, Issue:4 Topics: Adrenal Cortex Hormones; Analgesics; Chemical and Drug Induced Liver Injury; Cholestasis; Contracept	1975
Halothane on irradiated liver tissue. Strahlentherapie, 1975, Volume: 149, Issue:3 Topics: Acute Disease; Animals; Chronic Disease; Dose-Response Relationship, Drug; Dose-Response Relationshi	1975
[Rules for the histological evaluation of drug-induced liver lesions]. Deutsche medizinische Wochenschrift (1946), 1975, Aug-29, Volume: 100, Issue:35 Topics: Biopsy; Chemical and Drug Induced Liver Injury; Chlorpromazine; Cholestasis; Contraceptives, Oral; F	1975
Postoperative fever and the halothane controversy. Comprehensive therapy, 1975, Volume: 1, Issue:1 Topics: Anesthesia, General; Chemical and Drug Induced Liver Injury; Fever; Halothane; Humans; Malignant Hyp	1975
Spontaneous hepatic artery thrombosis with infarction of the liver. Gastroenterology, 1976, Volume: 70, Issue:4 Topics: Aged; Amputation, Surgical; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Diagnosi	1976
Subanesthetic halothane is hepatotoxic in the guinea pig. Anesthesia and analgesia, 1992, Volume: 74, Issue:4 Topics: Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, D	1992
The influence of hypothermia on hypoglycemia-induced brain damage in the rat. Acta neuropathologica, 1992, Volume: 83, Issue:4 Topics: Animals; Blood Glucose; Body Temperature; Brain; Brain Diseases; Halothane; Hypoglycemia; Hypothermi	1992
Covalent binding of oxidative biotransformation intermediates is associated with halothane hepatotoxicity in guinea pigs. Anesthesiology, 1990, Volume: 73, Issue:6 Topics: Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Halothane; Lipid Metabolism; Liv	1990
The pathology of halothane hepatotoxicity in a guinea-pig model: a comparison with human halothane hepatitis. British journal of experimental pathology, 1989, Volume: 70, Issue:5 Topics: Alanine Transaminase; Anesthesia, Inhalation; Animals; Chemical and Drug Induced Liver Injury; Disea	1989
[A clinicopathological study of 11 patients with acute drug-induced hepatic failure]. Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 1986, Volume: 83, Issue:12 Topics: Acute Disease; Adult; Aged; Chemical and Drug Induced Liver Injury; Ethionamide; Female; Halothane;	1986
Altered hepatic calcium homeostasis in guinea pigs with halothane-induced hepatotoxicity. The Journal of pharmacology and experimental therapeutics, 1988, Volume: 247, Issue:2 Topics: Alanine Transaminase; Animals; Calcium; Cytochrome P-450 Enzyme System; Female; Guinea Pigs; Halotha	1988
Halothane induced hepatic necrosis in rats: the role of in vivo lipid peroxidation. Pharmacology & toxicology, 1988, Volume: 63, Issue:5 Topics: Alanine Transaminase; Animals; Fatty Acids; Halothane; Lipid Metabolism; Lipid Peroxidation; Liver;	1988
Clinical report, "Hepatic necrosis following halothane anesthesia in goats," viewed as unacceptable. Journal of the American Veterinary Medical Association, 1987, May-01, Volume: 190, Issue:9 Topics: Animals; Chemical and Drug Induced Liver Injury; Goats; Halothane; Liver Diseases; Necrosis	1987
[Unexplained fatal hepatic necrosis following halothane--a case report]. Ma zui xue za zhi = Anaesthesiologica Sinica, 1987, Volume: 25, Issue:1 Topics: Aged; Anesthesia; Chemical and Drug Induced Liver Injury; Halothane; Humans; Male; Necrosis	1987
Hepatic effects of repeated halothane anesthetics in the hypoxic rat model. Anesthesiology, 1987, Volume: 67, Issue:3 Topics: Anesthesia, Inhalation; Animals; Halothane; Hypoxia; Liver; Male; Necrosis; Rats; Rats, Inbred F344;	1987
Hepatic necrosis following halothane anesthesia in goats. Journal of the American Veterinary Medical Association, 1986, Dec-15, Volume: 189, Issue:12 Topics: Anesthesia, General; Animals; Female; Goats; Halothane; Liver; Necrosis	1986
[Local anesthetics with added adrenaline during halothane anesthesia. Assessment of the risk of necrosis and systemic side effects when these preparations are employed peripherally]. Ugeskrift for laeger, 1987, Feb-02, Volume: 149, Issue:6 Topics: Anesthesia, Inhalation; Anesthetics, Local; Epinephrine; Halothane; Humans; Lidocaine; Necrosis; Ris	1987
Postcountershock myocardial damage after pretreatment with adrenergic and calcium channel antagonists in halothane-anesthetized dogs. Anesthesiology, 1985, Volume: 62, Issue:5 Topics: Anesthesia, Inhalation; Animals; Calcium Channel Blockers; Dogs; Electric Countershock; Female; Halo	1985
[Centrolobular liver cell necroses following occupational halothane contact. Association with antibodies to halothane altered liver cell components]. Zeitschrift fur Gastroenterologie, 1985, Volume: 23, Issue:4 Topics: Adult; Autoantibodies; Biopsy; Chemical and Drug Induced Liver Injury; Female; Halothane; Humans; Li	1985
The effect of the repeated administration of halothane on the liver of the horse. The Journal of pathology, 1970, Volume: 102, Issue:2 Topics: Adenosine Triphosphatases; Alcohol Oxidoreductases; Alkaline Phosphatase; Animals; Arginase; Asparta	1970
[Morphology and etiology of halothane-induced liver lesions (author's transl)]. Verhandlungen der Deutschen Gesellschaft fur Pathologie, 1972, Volume: 56 Topics: Adult; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Child; Cholestasis; Fatty Liv	1972
The effects of multiple anaesthetics on the livers of rats subjected to microsomal enzyme induction. A preliminary report. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1973, May-12, Volume: 47, Issue:18 Topics: Anesthetics; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Enzyme	1973
Experimental immunity to a metabolite of halothane and fluroxene: cutaneous delayed-type hypersensitivity. Anesthesiology, 1974, Volume: 40, Issue:4 Topics: Albumins; Animals; Biotransformation; Cattle; Chemical and Drug Induced Liver Injury; Disease Models	1974
Fatal brain damage after dental anaesthesia. Its nature, etiology, and prevention. Lancet (London, England), 1966, Oct-22, Volume: 2, Issue:7469 Topics: Adult; Anesthesia, Dental; Anesthesia, Inhalation; Brain Diseases; Halothane; Humans; Male; Methohex	1966
The effects of chloroform or halothane on horse liver in the early stage of ragwort poisoning. The Journal of pathology, 1972, Volume: 107, Issue:4 Topics: Adenosine Triphosphatases; Alkaline Phosphatase; Animals; Arginase; Bilirubin; Biopsy; Chemical and	1972
Ultrastructural changes in the nervous system after chronic exposure to halothane. Experimental neurology, 1974, Volume: 45, Issue:2 Topics: Animals; Brain Diseases; Cerebral Cortex; Chronic Disease; Endoplasmic Reticulum; Environmental Expo	1974
The spectrum of hepatotoxicity. Perspectives in biology and medicine, 1968,Autumn, Volume: 12, Issue:1 Topics: Aminosalicylic Acids; Anti-Bacterial Agents; Antimetabolites; Benzene Derivatives; Carbon Tetrachlor	1968
Post-anesthetic tissue necrosis in experimental pedicle skin flaps. Scandinavian journal of plastic and reconstructive surgery, 1969, Volume: 3, Issue:2 Topics: Acid-Base Equilibrium; Anesthetics; Animals; Blood Volume; Central Venous Pressure; Ethers; Graft vs	1969
Letter: Hepatic necrosis after enflurance anesthesia. JAMA, 1974, Apr-08, Volume: 228, Issue:2 Topics: Anesthesia; Chemical and Drug Induced Liver Injury; Female; Halothane; Humans; Hydrocarbons, Halogen	1974
[Exchange transfusion in the treatment of acute hepatic insufficiency]. Minerva chirurgica, 1974, Sep-30, Volume: 29, Issue:18 Topics: Acute Disease; Adolescent; Adult; Child; Child, Preschool; Exchange Transfusion, Whole Blood; Fatty	1974
Editorial: Halothane and liver damage. British medical journal, 1974, Sep-07, Volume: 3, Issue:5931 Topics: Anesthetics; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Halothane; Humans; Jaund	1974
Morphological results of the rat liver after the application of halothane and hypoxia. Acta hepato-gastroenterologica, 1974, Volume: 21, Issue:5 Topics: Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Cholinesterases; Endop	1974
Halothane metabolism and the liver. The New Zealand medical journal, 1973, Volume: 77, Issue:490 Topics: Anesthesia, General; Chemical and Drug Induced Liver Injury; Halothane; Humans; Liver; Necrosis; Ret	1973
A summary of the National Halothane Study. British journal of anaesthesia, 1972, Volume: 44, Issue:9 Topics: Chemical and Drug Induced Liver Injury; Halothane; Humans; Necrosis; United States	1972
Anesthesia and hepatic necrosis. American journal of obstetrics and gynecology, 1972, Aug-15, Volume: 113, Issue:8 Topics: Anesthetics; Chemical and Drug Induced Liver Injury; Cyclopropanes; Halothane; Humans; Necrosis	1972
[Early postoperative jaundice and peroperative liver diseases. Point of view of the anatomo-pathologist]. Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1972, Sep-05, Volume: 61, Issue:36 Topics: Anesthesia; Animals; Chemical and Drug Induced Liver Injury; Dogs; Halothane; Jaundice; Liver; Necro	1972
Fulminant hepatic failure. Postgraduate medicine, 1973, Volume: 53, Issue:1 Topics: Adolescent; Adult; Age Factors; Aged; Enzymes; Exchange Transfusion, Whole Blood; Halothane; Hepatic	1973
Halothane hepatitis. Canadian Medical Association journal, 1973, Jan-20, Volume: 108, Issue:2 Topics: Adult; Alkaline Phosphatase; Anesthesia, Inhalation; Aspartate Aminotransferases; Autopsy; Bilirubin	1973
The absence of effect of phenobarbital on halothane toxicity. Research communications in chemical pathology and pharmacology, 1973, Volume: 5, Issue:1 Topics: Aerosols; Animals; Aspartate Aminotransferases; Body Weight; Halothane; Kidney; L-Lactate Dehydrogen	1973
Halothane hepatitis--fact or fallacy. Acta anaesthesiologica Belgica, 1973, Volume: 24, Issue:2 Topics: Antibodies; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Drug Hypersensitivity;	1973
Ultrastructural pathology of a case of halothane hepatitis. The American journal of digestive diseases, 1973, Volume: 18, Issue:10 Topics: Adult; Chemical and Drug Induced Liver Injury; Halothane; Humans; Kupffer Cells; Liver; Male; Micros	1973
Histological appearances in fulminant hepatic failure with reference to aetiology, time of survival and role of immunological processes. Digestion, 1973, Volume: 8, Issue:1 Topics: Acetaminophen; Adolescent; Adult; Aged; Cell Nucleus; Chemical and Drug Induced Liver Injury; Haloth	1973
Acute hepatic failure treated by cross circulation. Archives of internal medicine, 1973, Volume: 132, Issue:4 Topics: Acute Disease; Adult; Anesthesia; Aspartate Aminotransferases; Bilirubin; Blood Donors; Blood Platel	1973
[Malignant hyperthermia during anesthesia]. Arkhiv patologii, 1973, Volume: 35, Issue:11 Topics: Adult; Anesthesia, Endotracheal; Animals; Autopsy; Brain Edema; Chick Embryo; Halothane; Hand; Heart	1973
Editorial: Fulminant hepatic failure. JAMA, 1973, Dec-03, Volume: 226, Issue:10 Topics: Age Factors; Aged; Anesthesia; Calcium; Chemical and Drug Induced Liver Injury; Exchange Transfusion	1973
Jaundice after repeated exposure to halothane: an analysis of Reports to the Committee on Safety of Medicines. British medical journal, 1974, Jan-05, Volume: 1, Issue:5896 Topics: Acute Disease; Adolescent; Adult; Age Factors; Aged; Anesthesia, Inhalation; England; Female; Haloth	1974
Halothane anesthesia, hepatic necrosis, and death: report of a case. Military medicine, 1967, Volume: 132, Issue:7 Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Female; Halothane; Humans; Middle Ag	1967
The biotransformation of halothane. Annals of the Royal College of Surgeons of England, 1971, Volume: 48, Issue:2 Topics: Animals; Autoradiography; Biotransformation; Carbon Isotopes; Chemical and Drug Induced Liver Injury	1971
Fatal hepatic necrosis and halothane. British medical journal, 1972, Jan-29, Volume: 1, Issue:5795 Topics: Chemical and Drug Induced Liver Injury; Female; Halothane; Humans; Middle Aged; Necrosis	1972
Skeletal fixation with self-curing polymethyl methacrylate. A report of 23 canine total hip replacements. Clinical orthopaedics and related research, 1972, Volume: 84 Topics: Acetabulum; Acrylic Resins; Anesthesia, Inhalation; Animals; Bone Development; Bone Resorption; Dogs	1972
Fatal hepatic necrosis associated with halothane anesthesia. American journal of obstetrics and gynecology, 1972, Apr-01, Volume: 112, Issue:7 Topics: Adult; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Female; Halothane; Hepatitis;	1972
Effects of phenobarbital pretreatment on the response of rat liver to halothane administration. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1972, Volume: 140, Issue:4 Topics: Anesthesia, General; Animals; Chemical and Drug Induced Liver Injury; Cytochromes; Enzyme Induction;	1972
The association of viral hepatitis and acute pancreatitis. California medicine, 1972, Volume: 117, Issue:3 Topics: Adult; Aged; Autolysis; Autopsy; Child, Preschool; Female; Halothane; Hepatitis A; Humans; Liver Dis	1972
Halothane hepatitis--an unsettled issue. The Nebraska medical journal, 1972, Volume: 57, Issue:10 Topics: Aged; Chemical and Drug Induced Liver Injury; Female; Halothane; Humans; Male; Middle Aged; Necrosis	1972
Halothane hepatitis. British medical journal, 1971, Jul-10, Volume: 3, Issue:5766 Topics: Chemical and Drug Induced Liver Injury; Halothane; Hepatitis A; Humans; Necrosis	1971
Acute massive hepatic necrosis with fatal liver failure. The American journal of digestive diseases, 1971, Volume: 16, Issue:9 Topics: Acute Disease; Adolescent; Adult; Aged; Anticonvulsants; Antitubercular Agents; Azathioprine; Blood	1971
Pig-liver perfusion. Extracorporeal pig-liver perfusion in a patient with acute hepatic failure. Scandinavian journal of gastroenterology, 1971, Volume: 6, Issue:5 Topics: Adult; Ammonia; Anesthesia, Inhalation; Animals; Autopsy; Bilirubin; Biopsy; Embolism; Female; Halot	1971
[Jaundice after halothane anesthesia]. Nordisk medicin, 1971, Oct-28, Volume: 85, Issue:43 Topics: Adult; Anesthesia; Aspartate Aminotransferases; Bilirubin; Body Temperature; Chemical and Drug Induc	1971
Fatal liver necrosis after repeated halothane anesthesia. Acta medica Iugoslavica, 1971, Volume: 25, Issue:1 Topics: Anesthesia; Chemical and Drug Induced Liver Injury; Halothane; Humans; Intestinal Obstruction; Middl	1971
Halothane anesthesia and postoperative liver necrosis. The Journal of the American Osteopathic Association, 1968, Volume: 68, Issue:1 Topics: Anesthesia, General; Chemical and Drug Induced Liver Injury; Cholecystectomy; Female; Halothane; Hum	1968
Fulminant hepatic necrosis following halothane anesthesia. The Medical annals of the District of Columbia, 1970, Volume: 39, Issue:7 Topics: Acute Disease; Chemical and Drug Induced Liver Injury; Female; Halothane; Humans; Middle Aged; Necro	1970
Hepatic necrosis associated with halothane anesthesia. The American journal of medicine, 1969, Volume: 47, Issue:5 Topics: Anesthesia; Autopsy; Biopsy; Chemical and Drug Induced Liver Injury; Cholestasis; Collagen; Connecti	1969
Haemobilia associated with hepatic necrosis after halothane anaesthesia. A case report. Annales chirurgiae et gynaecologiae Fenniae, 1969, Volume: 58, Issue:2 Topics: Anesthesia, Inhalation; Biliary Tract; Chemical and Drug Induced Liver Injury; Halothane; Hemorrhage	1969
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 10-1970. The New England journal of medicine, 1970, Mar-05, Volume: 282, Issue:10 Topics: Aged; Autopsy; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Female; Halothane; H	1970
[Liver necrosis after halothane anesthesia]. Ugeskrift for laeger, 1970, May-28, Volume: 132, Issue:22 Topics: Anesthesia, Inhalation; Halothane; Humans; Liver; Male; Middle Aged; Necrosis	1970
Liver necrosis after repeated fluothane anaesthesia. Cause or coincidence? Acta anaesthesiologica Scandinavica, 1970, Volume: 14, Issue:1 Topics: Adolescent; Aged; Anesthesia, General; Biopsy; Chemical and Drug Induced Liver Injury; Female; Halot	1970
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 24-1970. The New England journal of medicine, 1970, Jun-04, Volume: 282, Issue:23 Topics: Aged; Autopsy; Blood Coagulation Disorders; Chemical and Drug Induced Liver Injury; Diagnosis, Diffe	1970
Fatal halothane hepatitis with transient granulomas. The New England journal of medicine, 1970, 08-13, Volume: 283, Issue:7 Topics: Adult; Anesthesia, Inhalation; Autopsy; Biopsy; Chemical and Drug Induced Liver Injury; Drug Hyperse	1970
[Studies of the effect of an inhalation anesthesia and surgery on the liver function with special reference to halothane. 1]. Der Anaesthesist, 1970, Volume: 19, Issue:9 Topics: Alanine Transaminase; Anesthesia, Inhalation; Animals; Aspartate Aminotransferases; Bilirubin; Chemi	1970
[Postoperative toxic liver disease]. Zeitschrift fur arztliche Fortbildung, 1971, Mar-01, Volume: 65, Issue:5 Topics: Aged; Autopsy; Chemical and Drug Induced Liver Injury; Cholecystectomy; Cholelithiasis; Female; Halo	1971
[Halothane hepatitis]. La Presse medicale, 1971, Jun-05, Volume: 79, Issue:28 Topics: Chemical and Drug Induced Liver Injury; Female; Halothane; Humans; Hypersensitivity, Delayed; Liver;	1971
[Halothane and hepatic necrosis]. Gaceta medica de Mexico, 1967, Volume: 97, Issue:11 Topics: Adult; Anesthesia, Endotracheal; Halothane; Humans; Liver Diseases; Male; Necrosis	1967
Halothane and liver injury. The Medical letter on drugs and therapeutics, 1968, Jan-26, Volume: 10, Issue:2 Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Halothane; Humans; Liver; Liver Dise	1968
Hepatic necrosis following halothane anesthesia. The Alabama journal of medical sciences, 1968, Volume: 5, Issue:2 Topics: Chemical and Drug Induced Liver Injury; Female; Halothane; Humans; Necrosis	1968
Massive hepatic necrosis following multiple exposures to halothane. The American journal of medicine, 1968, Volume: 45, Issue:4 Topics: Aged; Brain; Diagnosis, Differential; Female; Halothane; Hemorrhage; Humans; Kidney; Kidney Diseases	1968
Multiple halothane anesthesia in the burn patient. JAMA, 1968, Sep-16, Volume: 205, Issue:12 Topics: Adolescent; Adult; Aged; Alanine Transaminase; Anesthesia, Inhalation; Aspartate Aminotransferases;	1968
Halothane-induced liver damage--an entity. The New England journal of medicine, 1969, Mar-06, Volume: 280, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Halothane; Humans; Liver; Liver Disea	1969
[Halothane and liver toxicity]. La Presse medicale, 1969, Mar-22, Volume: 77, Issue:14 Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Chloroform; Fever; Halothane; Hepati	1969
[Acute liver cell necrosis]. Nederlands tijdschrift voor geneeskunde, 1969, Jun-21, Volume: 113, Issue:25 Topics: Adult; Barbiturates; Chemical and Drug Induced Liver Injury; Female; Halothane; Humans; Liver; Liver	1969
The analgesic and anaesthetic actions of tetrafluorobenzene. British journal of pharmacology and chemotherapy, 1966, Volume: 26, Issue:2 Topics: Analgesics; Anesthesia, Inhalation; Anesthetics; Animals; Arrhythmias, Cardiac; Benzene; Blood Press	1966
Concerning hepatotoxicity of halothane. The New England journal of medicine, 1966, Dec-29, Volume: 275, Issue:26 Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Halothane; Humans; Necrosis	1966

halothane and Necrosis

Research Excerpts

Research

Studies (149)

Authors

Clinical Trials (1)

Trial Overview

Reviews

Trials

Other Studies

Authors	Studies
CHADWICK, DA	1
JENNINGS, RC	1
SLATER, EM	1
GIBSON, JM	1
DYKES, MH	2
WALZER, SG	1
MINUCK, M	1
SHERLOCK, S	1
GREEN, KG	1
MUNGAVIN, JM	1
AFFOLTER, H	1
HARTMANN, G	1
KAPFHAMMER, V	1
SCHEIDEGGER, S	1
BALESTRA, L	1
GIARDINA, B	1
URSO, L	1
DALMONTE, PR	1
BRESCHI, F	1
TURA, S	1
GINGRICH, TF	1
VIRTUE, RW	1
HILSCHER, A	1
Kumar, GP	1
Bhat, VJ	1
Sowdi, V	1
Yu, WF	1
Yang, LQ	1
Zhou, MT	1
Liu, ZQ	1
Li, Q	1
Babior, BM	1
Davidson, CS	2
Wibert, L	1
Creutzfeldt, W	1
Eger, W	1
Nassr-Esfahani, H	1
Eade, OE	2
Millward-Sadler, GH	1
Lucas, K	1
Mitchell, J	1
Wright, R	2
Black, M	1
Sinclair, M	1
Venning, GR	1
Plummer, JL	2
Hall, PD	4
Cousins, MJ	5
Bastin, FN	1
Ilsley, AH	1
Davis, RF	1
DeBoer, LW	1
Rude, RE	1
Lowenstein, E	1
Maroko, PR	1
Smith, AC	2
Berman, ML	3
James, RC	1
Harbison, RD	2
Takagi, T	1
Ishii, H	1
Takahashi, H	1
Kato, S	1
Okuno, F	1
Ebihara, Y	1
Yamauchi, H	1
Nagata, S	1
Tashiro, M	1
Tsuchiya, M	1
Gaunt, PS	1
Meuten, DJ	1
Pecquet-Goad, ME	1
Nastainczyk, W	1
Rendic, S	1
Ullrich, V	1
Krüger, R	1
Neuberger, J	3
Gimson, AE	2
Davis, M	2
Williams, R	6
Kuhnert, L	1
Phythyon, JM	2
Holaday, DA	1
Lewis, JH	1
Zimmerman, HJ	3
Ishak, KG	1
Mullick, FG	1
Knights, KM	2
Gourlay, GK	2
Hall, P	1
Maddrey, WC	2
Pohl, LR	1
Gillette, JR	1
Van Dyke, RA	1
Wyke, RJ	1
Canalese, JC	1
Bauer, G	1
Heidenreich, A	1
Findor, J	1
Bruch, E	1
Schmee, E	1
de Elizalde, S	1
Ferraina, P	1
Morel, C	1
Mieli-Vergani, G	1
Tredger, JM	1
Friend, SC	1
Wood, M	1
Hoyle, P	1
Wood, AJ	1
Groom, S	1
Checkley, S	1
Crawford, B	1
Lind, RC	4
Gandolfi, AJ	4
Hall, PM	2
Farrell, GC	2
Frost, L	2
Tapner, M	1
Field, J	1
Weltman, M	1
Mahoney, J	2
Shapira, Y	1
Lam, AM	1
Paez, A	1
Artru, AA	1
Laohaprasit, V	1
Donato, T	1
Mezin, P	1
Payen, JF	1
Bosson, JL	1
Brambilla, E	1
Stieglitz, P	1
Fukunaga, T	1
Davies, P	1
Zhang, L	1
Hashida, Y	1
Motoyama, EK	1
Chisholm, M	1
Hawksley, M	1
Lloyd, B	1
Moles, TM	1
Edwards, JC	1
GArdner, MJ	1
Trowell, J	1
Peto, R	1
Mitchell, JR	1
Potter, WZ	1
Rao, GS	2
Grumley, JO	1
Boitnott, JK	1
McLain, GE	1
Sipes, IG	2
Brown, BR	2
Ross, WT	1
Daggy, BP	1
Cardell, RR	1
Mazzia, VD	1
Simon, AH	1
Wills, EJ	1
Walton, B	2
Talbot, IC	1
Gopinath, G	1
Ford, EJ	3
Wolf, R	1
Barz, H	1
Chang, LW	2
Lee, YK	2
Dudley, AW	2
Katz, J	2
Brase, A	1
Emminger, E	1
Bockslaff, H	1
Bianchi, L	1
De Groote, J	1
Desmet, V	1
Gedigk, P	1
Korb, G	1
Popper, H	2
Poulsen, H	1
Scheuer, PJ	1
Schmid, M	1
Thaler, H	1
Wepler, W	1
Sadove, MS	1
Thomason, R	1
Redlin, TA	1
Katz, D	1
OConnor, PJ	1
Buhac, I	1
Balint, JA	1
Bird, GL	1
Agardh, CD	1
Smith, ML	1
Siesjö, BK	1
Lunam, CA	1
Seki, S	1
Mizoguchi, Y	1
Saito, S	1
Shiomi, S	1
Sakagami, Y	1
Sakaguchi, H	1
Kuroki, T	1
Harihara, S	1
Kobayashi, K	1
Monna, T	1
Bilous, M	1
Gibson, RA	1
Roschlau, G	1
Lumb, WV	1
Grandy, JL	1
Heath, RB	1
Dunlop, CI	1
Hodgson, DS	1
Jong, HJ	1
Ho, ST	1
Wong, CS	1
Hsu, JC	1
Chang, CL	1
Jenner, MA	1
O'Brien, TD	1
Raffe, MR	1
Cox, VS	1
Stevens, DL	1
O'Leary, TP	1
Grøntved, A	1
Eriksen, S	1
Gaba, DM	1
Metz, S	1
Maze, M	1
Schmidt, G	1
Börsch, G	1
Ricken, D	1
Müller, KM	1
Gopinath, C	2
Jones, RS	2
Klinge, O	1
Smith, JS	1
Harrison, GG	1
Mathieu, A	1
DiPadua, D	1
Mills, J	1
Kahan, B	1
Brierley, JB	1
Miller, AA	1
Sundell, B	1
Brander, P	1
Tammisto, T	1
Naccarato, R	1
Gritti, G	1
Giunta, F	1
Chiaramonte, M	1
Valenti, F	1
Leinweber, B	1
Cüppers, M	1
L'Allemand, H	1
Gilbert, JP	1
McPeek, B	1
Gottlieb, LS	1
Trey, C	1
LaMont, JT	1
McCaughey, W	1
Clark, RB	1
Jones, GL	1
Greifenstein, FE	1
Gardiol, D	1
Lepore, MJ	1
Qizilbash, AH	1
Barth, ML	1
Cornish, HH	1
Simpson, BR	2
Strunin, L	2
Waalton, B	1
Schatzki, PF	1
Kay, S	1
McGavic, JD	1
Goertz, J	1
Burnell, JM	1
Runge, C	1
Saunders, FC	1
Thomas, ED	1
Volwiler, W	1
Nesvetov, AM	1
Dovgiĭ, GM	1
L'vova, TN	1
Hussey, HH	1
Inman, WH	1
Mushin, WW	1
Belcher, HV	1
Remsberg, JR	1
Cohen, EN	1
Stenram, U	1
Amstutz, HC	1
Lurie, L	1
Bullough, P	1
Davis, JE	1
Stenger, RJ	1
Johnson, EA	1
Geokas, MC	1
Olsen, H	1
Swanson, V	1
Rinderknecht, H	1
Owen, DR	1
Schenken, JR	1
Caravati, CM	1
Hooker, TH	1
Lempinen, M	1
Collan, Y	1
Sivula, A	1
Merikallio, E	1
Salmenkivi, K	1
Paloheimo, M	1
Turunen, MT	1
Jokinen, EJ	1
Ahlqvist, J	1
Berglund, A	1
Satler, J	1
Voncina, J	1
Lippman, PA	1
Rivera, RA	1
McAllister, HA	1
Robinowitz, M	1
Peters, RL	1
Edmondson, HA	1
Reynolds, TB	1
Meister, JC	1
Curpey, TJ	1
Mäkelä, V	1
Lähdesmäki, M	1
Bog-Jensen, R	1
Hansen, V	1
Dordal, E	1
Glagov, S	1
Orlando, RA	1
Platz, C	1
Clauberg, G	1
Schwesinger, G	1
Pink, V	1
Braune, R	1
Celary, W	1
Dentan, M	1
Desmonts, JM	1
Berthelot, P	1
Robles, C	1
Kelley, J	1
Miller, RE	1
Gronert, GA	1
Schaner, PJ	1
Gunther, RC	1
Combes, B	1
Lande, M	1
Clot, C	1
Vos, AK	1
Neal, MJ	1
Robson, JM	1
DeBacker, LJ	1
Longnecker, DS	1
Babior, B	1