Voltage-dependent R-type calcium channel subunit alpha-1E

A voltage-dependent R-type calcium channel subunit alpha-1E that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q15878]

Brain calcium channel II;
BII;
Calcium channel, L type, alpha-1 polypeptide, isoform 6;
Voltage-gated calcium channel subunit alpha Cav2.3

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
tacrine	Homo sapiens (human)	IC50	17.0000	1	1
nimodipine	Homo sapiens (human)	IC50	14.0000	1	1
ith 4012	Homo sapiens (human)	IC50	20.0000	1	1

This protein enables 4 target(s):

Target	Category	Definition
voltage-gated calcium channel activity	molecular function	Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:mtg_transport, GOC:tb, ISBN:0815340729]
calcium ion binding	molecular function	Binding to a calcium ion (Ca2+). [GOC:ai]
voltage-gated monoatomic cation channel activity	molecular function	Enables the transmembrane transfer of a cation by a voltage-gated channel. A cation is a positively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:mtg_transport, ISBN:0815340729]
high voltage-gated calcium channel activity	molecular function	Enables the transmembrane transfer of a calcium ion by a high voltage-gated channel. A high voltage-gated channel is a channel whose open state is dependent on high voltage across the membrane in which it is embedded. [GOC:mtg_transport, ISBN:0815340729, PMID:16382099]

This protein is located in 2 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
synapse	cellular component	The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110]

This protein is active in 1 target(s):

Target	Category	Definition
neuronal cell body	cellular component	The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. [GOC:go_curators]

This protein is part of 1 target(s):

Target	Category	Definition
voltage-gated calcium channel complex	cellular component	A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential. [GOC:mah]

This protein is involved in 2 target(s):

Target	Category	Definition
calcium ion import across plasma membrane	biological process	The directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol. [GOC:dos]
chemical synaptic transmission	biological process	The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. [GOC:jl, MeSH:D009435]