Page last updated: 2024-08-07 23:28:01
Alpha-synuclein
An alpha-synuclein that is encoded in the genome of human. [PRO:DNx, UniProtKB:P37840]
Synonyms
Non-A beta component of AD amyloid;
Non-A4 component of amyloid precursor;
NACP
Research
Bioassay Publications (6)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 2 (33.33) | 2.80 |
Compounds (643)
Drugs with Potency Measurements
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| gallic acid | Homo sapiens (human) | IC50 | 4.4300 | 1 | 1 |
| hypericin | Homo sapiens (human) | IC50 | 7.5000 | 1 | 1 |
| vitamin k 3 | Homo sapiens (human) | IC50 | 15.0000 | 1 | 1 |
| masoprocol | Homo sapiens (human) | IC50 | 0.2150 | 2 | 2 |
| estriol | Homo sapiens (human) | IC50 | 20.1000 | 1 | 1 |
| estrone | Homo sapiens (human) | IC50 | 93.1000 | 1 | 1 |
| androstenedione | Homo sapiens (human) | IC50 | 85.9000 | 1 | 1 |
| phenothiazine | Homo sapiens (human) | IC50 | 26.0000 | 1 | 1 |
| phenothiazine | Homo sapiens (human) | Ki | 0.5000 | 1 | 1 |
| 1,4-naphthoquinone | Homo sapiens (human) | IC50 | 15.0000 | 1 | 1 |
| selegiline | Homo sapiens (human) | IC50 | 0.2700 | 1 | 1 |
| bromocriptine | Homo sapiens (human) | IC50 | 24.7000 | 1 | 1 |
| pergolide | Homo sapiens (human) | IC50 | 7.9000 | 1 | 1 |
| coomassie brilliant blue r | Homo sapiens (human) | IC50 | 322.0000 | 1 | 1 |
| gallocatechol | Homo sapiens (human) | IC50 | 8.9000 | 1 | 1 |
| delphinidin | Homo sapiens (human) | IC50 | 6.5000 | 1 | 1 |
| epicatechin | Homo sapiens (human) | IC50 | 15.3500 | 2 | 2 |
| gallocatechol | Homo sapiens (human) | IC50 | 10.6000 | 1 | 1 |
| epicatechin gallate | Homo sapiens (human) | IC50 | 9.8000 | 1 | 1 |
| procyanidin b2 | Homo sapiens (human) | IC50 | 4.3000 | 1 | 1 |
| (-)-gallocatechin gallate | Homo sapiens (human) | IC50 | 3.6000 | 1 | 1 |
| tretinoin | Homo sapiens (human) | IC50 | 3.0000 | 1 | 1 |
| retinol | Homo sapiens (human) | IC50 | 0.1900 | 1 | 1 |
| ferulic acid | Homo sapiens (human) | IC50 | 0.7500 | 1 | 1 |
| retinaldehyde | Homo sapiens (human) | IC50 | 0.1900 | 1 | 1 |
| curcumin | Homo sapiens (human) | IC50 | 81.0100 | 2 | 2 |
| quercetin | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| luteolin | Homo sapiens (human) | IC50 | 28.0000 | 1 | 1 |
| baicalein | Homo sapiens (human) | IC50 | 8.2000 | 1 | 1 |
| myricetin | Homo sapiens (human) | IC50 | 6.7600 | 2 | 2 |
| rosmarinic acid | Homo sapiens (human) | IC50 | 0.2100 | 1 | 1 |
| menatetrenone | Homo sapiens (human) | IC50 | 15.0000 | 1 | 1 |
| vitamin k 1 | Homo sapiens (human) | IC50 | 15.0000 | 1 | 1 |
| (-)-catechin-3-O-gallate | Homo sapiens (human) | IC50 | 21.4000 | 1 | 1 |
| su 4312 | Homo sapiens (human) | Ki | 0.0844 | 1 | 1 |
| procyanidin b1 | Homo sapiens (human) | IC50 | 7.3000 | 1 | 1 |
| tetracycline | Homo sapiens (human) | IC50 | 6.0600 | 1 | 1 |
| rifampin | Homo sapiens (human) | IC50 | 26.6500 | 2 | 2 |
| hydrazinocurcumin | Homo sapiens (human) | IC50 | 126.8000 | 1 | 1 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| thioflavin t | Homo sapiens (human) | Kd | 15.2000 | 1 | 1 |
| curcumin | Homo sapiens (human) | Kd | 3.5000 | 4 | 4 |
| ceftriaxone | Homo sapiens (human) | Kd | 0.5300 | 1 | 1 |
| 3-(1,3-benzodioxol-5-yl)-5-(3-bromophenyl)-1h-pyrazole | Homo sapiens (human) | Kd | 0.1900 | 1 | 1 |
Enables
This protein enables 24 target(s):
| Target | Category | Definition |
|---|---|---|
| SNARE binding | molecular function | Binding to a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein. [PMID:12642621] |
| magnesium ion binding | molecular function | Binding to a magnesium (Mg) ion. [GOC:ai] |
| transcription cis-regulatory region binding | molecular function | Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. [GOC:txnOH] |
| actin binding | molecular function | Binding to monomeric or multimeric forms of actin, including actin filaments. [GOC:clt] |
| protein kinase inhibitor activity | molecular function | Binds to and stops, prevents or reduces the activity of a protein kinase. [GOC:ai] |
| copper ion binding | molecular function | Binding to a copper (Cu) ion. [GOC:ai] |
| calcium ion binding | molecular function | Binding to a calcium ion (Ca2+). [GOC:ai] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| phospholipid binding | molecular function | Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester. [ISBN:0198506732] |
| ferrous iron binding | molecular function | Binding to a ferrous iron ion, Fe(II). [GOC:ai] |
| zinc ion binding | molecular function | Binding to a zinc ion (Zn). [GOC:ai] |
| lipid binding | molecular function | Binding to a lipid. [GOC:ai] |
| oxidoreductase activity | molecular function | Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. [GOC:go_curators] |
| kinesin binding | molecular function | Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation. [GOC:curators, PMID:8606779] |
| Hsp70 protein binding | molecular function | Binding to a Hsp70 protein, heat shock proteins around 70kDa in size. [ISBN:0198506732] |
| histone binding | molecular function | Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription. [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837] |
| identical protein binding | molecular function | Binding to an identical protein or proteins. [GOC:jl] |
| alpha-tubulin binding | molecular function | Binding to the microtubule constituent protein alpha-tubulin. [GOC:jl] |
| cysteine-type endopeptidase inhibitor activity involved in apoptotic process | molecular function | Binds to and stops, prevents or reduces the activity of a cysteine-type endopeptidase involved in the apoptotic process. [GOC:jl, GOC:mtg_apoptosis, PMID:14744432, Wikipedia:Caspase] |
| tau protein binding | molecular function | Binding to tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS. [GOC:jid] |
| phosphoprotein binding | molecular function | Binding to a phosphorylated protein. [GOC:ai] |
| molecular adaptor activity | molecular function | The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way. [GOC:mtg_MIT_16mar07, GOC:vw] |
| dynein complex binding | molecular function | Binding to a dynein complex, a protein complex that contains two or three dynein heavy chains and several light chains, and has microtubule motor activity. [GOC:bf, GOC:BHF, GOC:mah] |
| cuprous ion binding | molecular function | Binding to a cuprous ion, copper(1+). [GO_REF:0000067, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24567322] |
Located In
This protein is located in 18 target(s):
| Target | Category | Definition |
|---|---|---|
| extracellular region | cellular component | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators] |
| extracellular space | cellular component | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684] |
| nucleus | cellular component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
| mitochondrion | cellular component | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732] |
| lysosome | cellular component | A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. [GOC:mah, ISBN:0198506732] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| cell cortex | cellular component | The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. [GOC:mah, ISBN:0815316194] |
| actin cytoskeleton | cellular component | The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. [GOC:jl, ISBN:0395825172, ISBN:0815316194] |
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
| inclusion body | cellular component | A discrete intracellular part formed of aggregated molecules such as proteins or other biopolymers. [GOC:mah, PMID:11121744] |
| axon | cellular component | The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. [GOC:nln, ISBN:0198506732] |
| growth cone | cellular component | The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic. [GOC:aruk, GOC:bc, ISBN:0815316194, PMID:10082468] |
| synaptic vesicle membrane | cellular component | The lipid bilayer surrounding a synaptic vesicle. [GOC:mah] |
| perinuclear region of cytoplasm | cellular component | Cytoplasm situated near, or occurring around, the nucleus. [GOC:jid] |
| postsynapse | cellular component | The part of a synapse that is part of the post-synaptic cell. [GOC:dos] |
| supramolecular fiber | cellular component | A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure. [GOC:dos] |
Active In
This protein is active in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
| axon terminus | cellular component | Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it. [GOC:dph, GOC:jl] |
| neuronal cell body | cellular component | The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. [GOC:go_curators] |
Part Of
This protein is part of 1 target(s):
| Target | Category | Definition |
|---|---|---|
| protein-containing complex | cellular component | A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. [GOC:dos, GOC:mah] |
Involved In
This protein is involved in 76 target(s):
| Target | Category | Definition |
|---|---|---|
| negative regulation of transcription by RNA polymerase II | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH] |
| microglial cell activation | biological process | The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. [GOC:mgi_curators, PMID:10626665, PMID:10695728, PMID:12580336, PMID:9893949] |
| positive regulation of receptor recycling | biological process | Any process that activates or increases the frequency, rate or extent of receptor recycling. [GOC:add] |
| positive regulation of neurotransmitter secretion | biological process | Any process that activates or increases the frequency, rate or extent of the regulated release of a neurotransmitter. [GOC:hjd] |
| negative regulation of protein kinase activity | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity. [GOC:go_curators] |
| fatty acid metabolic process | biological process | The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. [ISBN:0198547684] |
| neutral lipid metabolic process | biological process | The chemical reactions and pathways involving neutral lipids, lipids only soluble in solvents of very low polarity. [ISBN:0198547684] |
| phospholipid metabolic process | biological process | The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester. [ISBN:0198506732] |
| activation of cysteine-type endopeptidase activity involved in apoptotic process | biological process | Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process. [GOC:al, GOC:dph, GOC:jl, GOC:mtg_apoptosis, GOC:tb, PMID:14744432, PMID:18328827, Wikipedia:Caspase] |
| mitochondrial membrane organization | biological process | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrial membrane, either of the lipid bilayer surrounding a mitochondrion. [GOC:ai, GOC:dph, GOC:jl, GOC:mah] |
| adult locomotory behavior | biological process | Locomotory behavior in a fully developed and mature organism. [GOC:ai] |
| response to xenobiotic stimulus | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:jl, GOC:krc] |
| response to iron(II) ion | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron(II) ion stimulus. [GOC:sm] |
| regulation of phospholipase activity | biological process | Any process that modulates the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid. [GOC:BHF, GOC:dph, GOC:tb] |
| negative regulation of platelet-derived growth factor receptor signaling pathway | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of the platelet-derived growth factor receptor signaling pathway. [GOC:dph, GOC:hjd, GOC:tb] |
| regulation of glutamate secretion | biological process | Any process that modulates the frequency, rate or extent of the controlled release of glutamate. [GOC:ef] |
| regulation of dopamine secretion | biological process | Any process that modulates the frequency, rate or extent of the regulated release of dopamine. [GOC:ef] |
| synaptic vesicle exocytosis | biological process | Fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft. [GOC:jid, GOC:lmg] |
| synaptic vesicle priming | biological process | A process that converts synaptic vesicles to a state of competence for calcium triggered fusion with the active zone membrane by bringing the two membranes into very close proximity. Priming typically (but not always) occurs after docking (Jahn and Fasshauer, 2012). Primed vesicles are also capable of spontaneously fusing with the active zone membrane. [GOC:mah, PMID:15217342, PMID:23060190] |
| regulation of transmembrane transporter activity | biological process | Any process that modulates the frequency, rate or extent of transmembrane transporter activity. [GOC:dph, GOC:mtg_cardio, GOC:mtg_transport] |
| negative regulation of microtubule polymerization | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization. [GOC:mah] |
| receptor internalization | biological process | A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane. [GOC:bf, GOC:mah, GOC:signaling, PMID:15006537, PMID:19643732] |
| protein destabilization | biological process | Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation. [GOC:mah] |
| response to magnesium ion | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnesium ion stimulus. [GOC:mah] |
| negative regulation of transporter activity | biological process | Any process that stops or reduces the activity of a transporter. [GOC:mah] |
| response to lipopolysaccharide | biological process | Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria. [GOC:add, ISBN:0721601464] |
| negative regulation of monooxygenase activity | biological process | Any process that stops or reduces the activity of a monooxygenase. [GOC:mah] |
| positive regulation of peptidyl-serine phosphorylation | biological process | Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine. [GOC:mah] |
| response to type II interferon | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon-gamma is also known as type II interferon. [GOC:add, ISBN:0126896631, PMID:15546383] |
| cellular response to oxidative stress | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. [GOC:mah] |
| SNARE complex assembly | biological process | The aggregation, arrangement and bonding together of a set of components to form a SNARE complex, a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. [GOC:rb, PMID:10872468] |
| positive regulation of SNARE complex assembly | biological process | Any process that increases the frequency, rate or extent of assembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. [GOC:rb] |
| regulation of locomotion | biological process | Any process that modulates the frequency, rate or extent of locomotion of a cell or organism. [GOC:ems] |
| dopamine biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline. [GOC:jl, ISBN:0198506732] |
| mitochondrial ATP synthesis coupled electron transport | biological process | The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane or chloroplast thylakoid membrane. [GOC:mtg_sensu, ISBN:0716731363] |
| regulation of macrophage activation | biological process | Any process that modulates the frequency or rate of macrophage activation. [GOC:jl] |
| positive regulation of apoptotic process | biological process | Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis] |
| negative regulation of apoptotic process | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis] |
| negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process. [GOC:jl, GOC:mtg_apoptosis] |
| negative regulation of neuron apoptotic process | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons. [GOC:go_curators, GOC:mtg_apoptosis] |
| positive regulation of endocytosis | biological process | Any process that activates or increases the frequency, rate or extent of endocytosis. [GOC:go_curators] |
| negative regulation of exocytosis | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of exocytosis. [GOC:go_curators] |
| positive regulation of exocytosis | biological process | Any process that activates or increases the frequency, rate or extent of exocytosis. [GOC:go_curators] |
| regulation of long-term neuronal synaptic plasticity | biological process | A process that modulates long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers. [GOC:jid, PMID:11891290] |
| synaptic vesicle endocytosis | biological process | A vesicle-mediated transport process, in which the synaptic vesicle membrane constituents are retrieved from the presynaptic membrane on the axon terminal after neurotransmitter secretion by exocytosis. Synaptic vesicle endocytosis can occur via clathrin-dependent and clathrin-independent mechanisms. [GOC:aruk, GOC:bc, GOC:jid, GOC:lmg, GOC:mah, PMID:20448150, PMID:26430111] |
| synaptic vesicle transport | biological process | The directed movement of synaptic vesicles. [GOC:aruk, GOC:bc, GOC:jid, GOC:lmg, GOC:pr] |
| positive regulation of inflammatory response | biological process | Any process that activates or increases the frequency, rate or extent of the inflammatory response. [GOC:ai] |
| regulation of acyl-CoA biosynthetic process | biological process | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of acyl-CoA. [GOC:ai] |
| protein tetramerization | biological process | The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits. [GOC:ecd] |
| positive regulation of release of sequestered calcium ion into cytosol | biological process | Any process that activates or increases the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria. [GOC:ai] |
| neuron apoptotic process | biological process | Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system. [CL:0000540, GOC:mtg_apoptosis] |
| dopamine uptake involved in synaptic transmission | biological process | The directed movement of dopamine into a presynaptic neuron or glial cell. In this context, dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline. [GOC:ai] |
| negative regulation of dopamine uptake involved in synaptic transmission | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of dopamine into a presynaptic neuron or glial cell. [GOC:ai] |
| negative regulation of serotonin uptake | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of serotonin into a cell. [GOC:ai] |
| regulation of norepinephrine uptake | biological process | Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter norepinephrine into a cell. [GOC:ai] |
| negative regulation of norepinephrine uptake | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of norepinephrine into a cell. [GOC:ai] |
| excitatory postsynaptic potential | biological process | A process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential. [GOC:dph, GOC:ef] |
| long-term synaptic potentiation | biological process | A process that modulates synaptic plasticity such that synapses are changed resulting in the increase in the rate, or frequency of synaptic transmission at the synapse. [GOC:dgh, GOC:dph] |
| positive regulation of inositol phosphate biosynthetic process | biological process | Any process that increases the rate, frequency or extent of inositol phosphate biosynthesis. Inositol phosphate biosynthetic processes are the chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached. [GOC:dph, GOC:tb] |
| negative regulation of thrombin-activated receptor signaling pathway | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of thrombin-activated receptor protein signaling pathway activity. A thrombin receptor signaling pathway is the series of molecular signals generated as a consequence of a thrombin-activated receptor binding to one of its physiological ligands. [GOC:mah] |
| response to interleukin-1 | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus. [GOC:BHF, GOC:mah] |
| cellular response to copper ion | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus. [GOC:mah] |
| cellular response to epinephrine stimulus | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epinephrine stimulus. Epinephrine is a catecholamine that has the formula C9H13NO3; it is secreted by the adrenal medulla to act as a hormone, and released by certain neurons to act as a neurotransmitter active in the central nervous system. [GOC:BHF, GOC:mah] |
| positive regulation of protein serine/threonine kinase activity | biological process | Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity. [GOC:mah] |
| supramolecular fiber organization | biological process | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a supramolecular fiber, a polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure. [GOC:pr] |
| negative regulation of mitochondrial electron transport, NADH to ubiquinone | biological process | Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial electron transport, NADH to ubiquinone. [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:23530063] |
| positive regulation of glutathione peroxidase activity | biological process | Any process that activates or increases the frequency, rate or extent of glutathione peroxidase activity. [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23507046] |
| positive regulation of hydrogen peroxide catabolic process | biological process | Any process that activates or increases the frequency, rate or extent of hydrogen peroxide catabolic process. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23507046] |
| regulation of synaptic vesicle recycling | biological process | Any process that modulates the frequency, rate or extent of synaptic vesicle recycling. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22745285] |
| regulation of reactive oxygen species biosynthetic process | biological process | Any process that modulates the frequency, rate or extent of reactive oxygen species biosynthetic process. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804] |
| positive regulation of protein localization to cell periphery | biological process | Any process that activates or increases the frequency, rate or extent of protein localization to cell periphery. [GO_REF:0000058, GOC:TermGenie, PMID:18216290] |
| negative regulation of chaperone-mediated autophagy | biological process | Any process that stops, prevents or reduces the frequency, rate or extent of chaperone-mediated autophagy. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20176123] |
| regulation of presynapse assembly | biological process | Any process that modulates the frequency, rate or extent of presynapse assembly. [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:25533483] |
| amyloid fibril formation | biological process | The generation of amyloid fibrils, insoluble fibrous protein aggregates exhibiting beta sheet structure, from proteins. [GOC:cvs, GOC:jj, GOC:ppm, GOC:sj, PMID:21148556, PMID:22817896, PMID:28937655, PMID:29654159] |
| synapse organization | biological process | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). [GOC:ai, GOC:pr] |
| chemical synaptic transmission | biological process | The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. [GOC:jl, MeSH:D009435] |