Proteins > Alpha-synuclein
Page last updated: 2024-08-07 23:28:01

Alpha-synuclein

An alpha-synuclein that is encoded in the genome of human. [PRO:DNx, UniProtKB:P37840]

Synonyms

Non-A beta component of AD amyloid;
Non-A4 component of amyloid precursor;
NACP

Research

Bioassay Publications (6)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (66.67)24.3611
2020's2 (33.33)2.80

Compounds (643)

Drugs with Potency Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
allantoinHomo sapiens (human)Potency5.623410
[3-carboxy-2-(1-oxohexadecoxy)propyl]-trimethylammoniumHomo sapiens (human)Potency25.929010
s,s'-1,4-phenylene-bis(1,2-ethanediyl)bis-isothioureaHomo sapiens (human)Potency20.596210
ro 5-4864Homo sapiens (human)Potency11.220210
4,5,6,7-tetrabromo-2-azabenzimidazoleHomo sapiens (human)Potency2.592910
p-chloromercuribenzoic acidHomo sapiens (human)Potency4.483610
phenanthridoneHomo sapiens (human)Potency15.848910
6-nitroso-1,2-benzopyroneHomo sapiens (human)Potency18.356410
8-cyclopentyl-1,3-dimethylxanthineHomo sapiens (human)Potency6.513110
oxyquinolineHomo sapiens (human)Potency25.118910
abt 702Homo sapiens (human)Potency20.596210
aurintricarboxylic acidHomo sapiens (human)Potency4.109510
benzbromaroneHomo sapiens (human)Potency2.238710
benzo(b)thiophene-2-boronic acidHomo sapiens (human)Potency35.481310
bay h 4502Homo sapiens (human)Potency2.511910
calmidazoliumHomo sapiens (human)Potency5.804810
cantharidinHomo sapiens (human)Potency4.610910
carmustineHomo sapiens (human)Potency18.356410
cetylpyridiniumHomo sapiens (human)Potency14.125410
chloroxineHomo sapiens (human)Potency4.466810
clioquinolHomo sapiens (human)Potency4.007510
clofoctolHomo sapiens (human)Potency25.118910
clotrimazoleHomo sapiens (human)Potency0.651310
cloxyquinHomo sapiens (human)Potency35.481310
dephostatinHomo sapiens (human)Potency19.373610
dequaliniumHomo sapiens (human)Potency23.109310
dichlorophenHomo sapiens (human)Potency35.481310
disulfiramHomo sapiens (human)Potency5.173510
doxazosinHomo sapiens (human)Potency5.623410
ebastineHomo sapiens (human)Potency29.092910
ebselenHomo sapiens (human)Potency4.478010
ethionHomo sapiens (human)Potency10.000010
felodipineHomo sapiens (human)Potency29.092910
flufenamic acidHomo sapiens (human)Potency25.118910
flutamideHomo sapiens (human)Potency22.387210
gentian violetHomo sapiens (human)Potency11.220210
gossypolHomo sapiens (human)Potency6.796310
hexachloropheneHomo sapiens (human)Potency3.548110
hexestrolHomo sapiens (human)Potency19.952610
indirubin-3'-monoximeHomo sapiens (human)Potency2.592910
isoconazoleHomo sapiens (human)Potency0.562310
itraconazoleHomo sapiens (human)Potency2.238710
1-(2-naphthalenyl)-3-[(phenylmethyl)-propan-2-ylamino]-1-propanoneHomo sapiens (human)Potency11.478210
lansoprazoleHomo sapiens (human)Potency29.092910
beta-lapachoneHomo sapiens (human)Potency22.387210
mequitazineHomo sapiens (human)Potency5.623410
methoctramineHomo sapiens (human)Potency2.310910
moclobemideHomo sapiens (human)Potency3.981110
fenamic acidHomo sapiens (human)Potency35.481310
nialamideHomo sapiens (human)Potency25.118910
niclosamideHomo sapiens (human)Potency1.413710
niflumic acidHomo sapiens (human)Potency16.360110
oxaprozinHomo sapiens (human)Potency25.929010
pd 169316Homo sapiens (human)Potency9.200010
pomiferinHomo sapiens (human)Potency35.481310
ag 1879Homo sapiens (human)Potency2.375310
ppm 18Homo sapiens (human)Potency4.466810
promazineHomo sapiens (human)Potency4.466810
3-[(3,5-dibromo-4-hydroxyphenyl)methylidene]-5-iodo-1H-indol-2-oneHomo sapiens (human)Potency3.162310
pf 5901Homo sapiens (human)Potency26.918810
riluzoleHomo sapiens (human)Potency11.582110
sanguinarineHomo sapiens (human)Potency32.287110
ACar 18-0Homo sapiens (human)Potency20.596210
thiramHomo sapiens (human)Potency5.011910
triclosanHomo sapiens (human)Potency11.220210
tyrphostin a9Homo sapiens (human)Potency1.925910
3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazoleHomo sapiens (human)Potency22.851810
dehydroepiandrosteroneHomo sapiens (human)Potency2.238710
azauridineHomo sapiens (human)Potency5.623410
pentylenetetrazoleHomo sapiens (human)Potency6.513110
methylene blueHomo sapiens (human)Potency15.848910
cycloheximideHomo sapiens (human)Potency1.584910
medroxyprogesterone acetateHomo sapiens (human)Potency5.623410
n,n'-diphenyl-4-phenylenediamineHomo sapiens (human)Potency31.622810
tetrabromobisphenol aHomo sapiens (human)Potency8.912510
quinophthaloneHomo sapiens (human)Potency3.981110
quinolineHomo sapiens (human)Potency3.981110
1,2-diaminobenzeneHomo sapiens (human)Potency12.589310
fentichlorHomo sapiens (human)Potency12.589310
methylenebis(chloroaniline)Homo sapiens (human)Potency31.622810
triclocarbanHomo sapiens (human)Potency0.815510
benzethonium chlorideHomo sapiens (human)Potency22.387210
sulfan blueHomo sapiens (human)Potency11.220210
4-nitrosodimethylanilineHomo sapiens (human)Potency17.782810
sterogenolHomo sapiens (human)Potency10.000010
diphenhydramine hydrochlorideHomo sapiens (human)Potency3.548110
lithocholic acidHomo sapiens (human)Potency5.011910
kokusaginineHomo sapiens (human)Potency10.000010
dibromsalicilHomo sapiens (human)Potency0.891310
dazometHomo sapiens (human)Potency2.818410
evernic acidHomo sapiens (human)Potency35.481310
nitrophenideHomo sapiens (human)Potency3.981110
isoxsuprine hydrochlorideHomo sapiens (human)Potency2.818410
pentabromophenolHomo sapiens (human)Potency2.511910
3,4,5-trichlorophenolHomo sapiens (human)Potency11.220210
2'-deoxy-5'-adenosine monophosphateHomo sapiens (human)Potency14.125410
indole-3-acetic acid ethyl esterHomo sapiens (human)Potency5.623410
2-amino-7-nitrofluoreneHomo sapiens (human)Potency35.481310
dehydroepiandrosterone acetateHomo sapiens (human)Potency11.220210
carmineHomo sapiens (human)Potency11.220210
pregnenolone carbonitrileHomo sapiens (human)Potency25.118910
bisphenol a-glycidyl methacrylateHomo sapiens (human)Potency35.481310
tetrachloroisophthalonitrileHomo sapiens (human)Potency1.412510
2,4-diacetylphloroglucinolHomo sapiens (human)Potency15.848910
azaribineHomo sapiens (human)Potency31.622810
ethyl violetHomo sapiens (human)Potency2.511910
2-amino-2',5-dichlorobenzophenoneHomo sapiens (human)Potency19.952610
n-(4-dimethylamino-3,5-dinitrophenyl)maleimideHomo sapiens (human)Potency5.623410
nitroxolineHomo sapiens (human)Potency15.848910
1,6-bismaleimidohexaneHomo sapiens (human)Potency6.309610
2,3,4,5-tetrachlorophenateHomo sapiens (human)Potency7.079510
fenestrelHomo sapiens (human)Potency10.000010
clioxanideHomo sapiens (human)Potency35.481310
n-(cyclohexylthio)phthalimideHomo sapiens (human)Potency14.125410
cetyldimethylethylammonium bromideHomo sapiens (human)Potency12.589310
ursodeoxycholic acidHomo sapiens (human)Potency35.481310
(7S,9S)-7-[(4-amino-5-hydroxy-6-methyl-2-oxanyl)oxy]-6,9,11-trihydroxy-9-(2-hydroxy-1-oxoethyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dioneHomo sapiens (human)Potency35.481310
2-n-octyl-4-isothiazolin-3-oneHomo sapiens (human)Potency3.981110
enilconazoleHomo sapiens (human)Potency3.548110
wr 171,699Homo sapiens (human)Potency35.481310
isovelleralHomo sapiens (human)Potency6.309610
triadimefonHomo sapiens (human)Potency1.122010
lonidamineHomo sapiens (human)Potency29.092910
NanaomycinHomo sapiens (human)Potency0.354810
nicardipine hydrochlorideHomo sapiens (human)Potency5.623410
triadimenolHomo sapiens (human)Potency0.354810
triclabendazoleHomo sapiens (human)Potency1.995310
azelastine hydrochlorideHomo sapiens (human)Potency22.387210
mibefradilHomo sapiens (human)Potency29.092910
duloxetine hydrochlorideHomo sapiens (human)Potency5.623410
sudan black bHomo sapiens (human)Potency12.589310
daunorubicin hydrochlorideHomo sapiens (human)Potency4.466810
xanthyletineHomo sapiens (human)Potency5.623410
epirubicin hydrochlorideHomo sapiens (human)Potency25.118910
17 beta-estradiol hemisuccinateHomo sapiens (human)Potency25.118910
meconinHomo sapiens (human)Potency31.622810
miconazole nitrateHomo sapiens (human)Potency17.782810
econazole nitrateHomo sapiens (human)Potency0.562310
sanguinarine chlorideHomo sapiens (human)Potency39.810710
bithionol sulfoxideHomo sapiens (human)Potency7.943310
2,6-di-tert-butyl-4-nitrophenolHomo sapiens (human)Potency35.481310
2,3,4-trihydroxbenzophenoneHomo sapiens (human)Potency35.481310
2,2',2''-terpyridineHomo sapiens (human)Potency35.481310
masoprocolHomo sapiens (human)Potency29.092910
3-octadecanamido-2-ethoxypropylphosphocholineHomo sapiens (human)Potency29.092910
honokiolHomo sapiens (human)Potency35.481310
methyl fluorone blackHomo sapiens (human)Potency10.000010
1,10-phenanthroline-5,6-dioneHomo sapiens (human)Potency10.000010
2-chloranilHomo sapiens (human)Potency31.622810
amperozide hydrochlorideHomo sapiens (human)Potency22.387210
n-benzylmaleimideHomo sapiens (human)Potency17.782810
OroseloneHomo sapiens (human)Potency5.011910
2-phenylisatogenHomo sapiens (human)Potency35.481310
4-(2-thiazolylazo)resorcinolHomo sapiens (human)Potency2.238710
2-methyl-4-nitroquinoline 1-oxideHomo sapiens (human)Potency3.981110
2-(carboxymethylthio)benzothiazoleHomo sapiens (human)Potency17.782810
8-(4-tolylsulfonylamino)quinolineHomo sapiens (human)Potency35.481310
n-(4-(2-benzoxazolyl)phenyl)maleimideHomo sapiens (human)Potency4.466810
fluazinamHomo sapiens (human)Potency1.778310
1-(2-thiazolylazo)-2-naphtholHomo sapiens (human)Potency7.943310
cortisol octanoateHomo sapiens (human)Potency31.622810
bnps-skatoleHomo sapiens (human)Potency5.623410
efuamideHomo sapiens (human)Potency10.000010
diffractaic acidHomo sapiens (human)Potency35.481310
ska-31Homo sapiens (human)Potency2.511910
1-phenazinecarboxylic acidHomo sapiens (human)Potency35.481310
phellopterinHomo sapiens (human)Potency14.125410
3-[3-(trifluoromethyl)phenyl]-1-methylureaHomo sapiens (human)Potency17.782810
zpckHomo sapiens (human)Potency12.500910
2-(3'-methoxy-4'-hydroxybenzylidene)cyclopentene-1,3-dioneHomo sapiens (human)Potency1.000010
alphaxaloneHomo sapiens (human)Potency25.929010
cp-55,940Homo sapiens (human)Potency20.327410
cv 3988Homo sapiens (human)Potency29.092910
ZearalanoneHomo sapiens (human)Potency15.848910
1-(carboxymethylthio)tetradecaneHomo sapiens (human)Potency29.092910
pd 128042Homo sapiens (human)Potency14.125410
glabridinHomo sapiens (human)Potency15.848910
1-(2-hydroxyethyl)-3,5-diphenyl-1h-pyrazoleHomo sapiens (human)Potency5.623410
omeprazole magnesiumHomo sapiens (human)Potency31.622810
n-(6-methoxy-8-quinolyl)-4-toluenesulfonamideHomo sapiens (human)Potency25.118910
4,8-dimethyl-5'-carboxypsoralenHomo sapiens (human)Potency11.220210
2-chloroacetoacetanilideHomo sapiens (human)Potency10.000010
2-methyl-4-(phenylimino)naphth(2,3-d)oxazol-9-oneHomo sapiens (human)Potency5.623410
8-(4-benzenesulfonylamino)quinolineHomo sapiens (human)Potency35.481310
2-phenyl-1,2-benzisothiazol-3-(2h)-oneHomo sapiens (human)Potency22.387210
barbatic acidHomo sapiens (human)Potency5.623410
17 alpha-hydroxyprogesterone caproateHomo sapiens (human)Potency35.481310
abt 980Homo sapiens (human)Potency32.287110
chrysomycin bHomo sapiens (human)Potency6.309610
nbi 27914Homo sapiens (human)Potency16.360110
sorafenibHomo sapiens (human)Potency8.912510
1-Anilino-9,10-dioxo-2-anthroic acidHomo sapiens (human)Potency12.589310
erythritolHomo sapiens (human)Potency35.481310
2-carbazol-9-ylbenzoic acidHomo sapiens (human)Potency35.481310
N-tert-butyl-6-ethyl-1-phenyl-4-pyrazolo[3,4-d]pyrimidinamineHomo sapiens (human)Potency35.481310
adrenosteroneHomo sapiens (human)Potency5.623410
acetoxycycloheximideHomo sapiens (human)Potency5.623410
2-pyridin-4-yl-1,3-benzothiazoleHomo sapiens (human)Potency12.589310
1-benzothiophen-2-yl-(4-dimethylaminophenyl)methanolHomo sapiens (human)Potency14.125410
anisomycinHomo sapiens (human)Potency28.183810
gardenin aHomo sapiens (human)Potency25.118910
nsc 95397Homo sapiens (human)Potency19.546410
1-phenyl-3-(3,4,5-trimethoxyphenyl)-2-propen-1-oneHomo sapiens (human)Potency22.387210
nsc-126771Homo sapiens (human)Potency5.011910
brusatolHomo sapiens (human)Potency28.183810
wortmanninHomo sapiens (human)Potency5.011910
nsc228155Homo sapiens (human)Potency0.562310
rocaglamideHomo sapiens (human)Potency10.000010
2,3-dichloro-5,8-dimethoxy-1,4-naphthoquinoneHomo sapiens (human)Potency2.818410
nsc 680410Homo sapiens (human)Potency19.952610
nexavarHomo sapiens (human)Potency17.782810
1-methoxy-10H-acridin-9-oneHomo sapiens (human)Potency25.118910
9-deazaadenosineHomo sapiens (human)Potency11.220210
tosylphenylalanyl chloromethyl ketoneHomo sapiens (human)Potency16.360110
beta-chloro-l-alanineHomo sapiens (human)Potency9.200010
epiandrosteroneHomo sapiens (human)Potency3.981110
doxorubicin hydrochlorideHomo sapiens (human)Potency4.466810
roxithromycinHomo sapiens (human)Potency6.309610
mycophenolic acidHomo sapiens (human)Potency7.079510
5,11-diethyl-5,6,11,12-tetrahydrochrysene-2,8-diolHomo sapiens (human)Potency18.356410
t0901317Homo sapiens (human)Potency35.481310
adenosine-5'-(n-ethylcarboxamide)Homo sapiens (human)Potency28.183810
diethylstilbestrolHomo sapiens (human)Potency35.481310
ketoconazoleHomo sapiens (human)Potency3.443710
meso-dihydroguaiaretic acidHomo sapiens (human)Potency17.782810
glyasperin DHomo sapiens (human)Potency35.481310
4-(2-oxazolo[4,5-b]pyridinyl)anilineHomo sapiens (human)Potency15.848910
8-isopentenylnaringeninHomo sapiens (human)Potency19.952610
IPA-3Homo sapiens (human)Potency7.307810
2-sulfanylidene-1,3-dithiole-4,5-dicarboxylic acid dimethyl esterHomo sapiens (human)Potency17.782810
4-(4-chloro-2-methylphenoxy)-n-hydroxybutanamideHomo sapiens (human)Potency12.589310
4-chloro-N-(4-chloro-2,5-dimethoxyphenyl)-5-dithiazolimineHomo sapiens (human)Potency7.506010
5-(4-nitrophenyl)-4-phenyl-2-thiazolamineHomo sapiens (human)Potency2.818410
idarubicin hydrochlorideHomo sapiens (human)Potency31.622810
pirarubicin hydrochlorideHomo sapiens (human)Potency28.183810
niflumic acidHomo sapiens (human)Potency5.623410
isoliquiritigeninHomo sapiens (human)Potency32.642710
xanthoangelolHomo sapiens (human)Potency35.481310
calmidazoliumHomo sapiens (human)Potency16.803710
9-methyl-6H-benzo[c][1,2]benzothiazine 5,5-dioxideHomo sapiens (human)Potency12.589310
5-hydroxy-N,N-dimethyl-2-phenyl-3-benzofurancarboxamideHomo sapiens (human)Potency22.387210
N-(4-fluorophenyl)-3-[(5-pyridin-4-yl-1,3,4-oxadiazol-2-yl)thio]propanamideHomo sapiens (human)Potency35.481310
2-amino-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d][1,3]thiazin-4-oneHomo sapiens (human)Potency2.238710
N-[2-[(3-cyano-6-ethoxy-2-quinolinyl)amino]ethyl]propanamideHomo sapiens (human)Potency35.481310
N-(4-chlorophenyl)-3-[(5-pyridin-4-yl-1,3,4-oxadiazol-2-yl)thio]propanamideHomo sapiens (human)Potency1.995310
2-acetyl-6-amino-8-(2-phenylethyl)-1,3,8,8a-tetrahydroisoquinoline-5,7,7-tricarbonitrileHomo sapiens (human)Potency6.309610
N-(4-methylphenyl)-2-(3-oxo-5,6-dihydroimidazo[2,1-b]thiazol-2-yl)acetamideHomo sapiens (human)Potency35.481310
N-cyclopropyl-4-(2,3-dihydroindol-1-ylsulfonyl)benzenesulfonamideHomo sapiens (human)Potency17.782810
1-(4-chlorophenyl)-N-(2-furanylmethyl)-N-[[1-(2-methylbutan-2-yl)-5-tetrazolyl]methyl]methanamineHomo sapiens (human)Potency31.622810
3-chloro-4-[4-(4-fluorophenyl)sulfonyl-1-piperazinyl]-N,N-dimethylbenzenesulfonamideHomo sapiens (human)Potency3.981110
2-[(2-cyclohexyl-4-quinazolinyl)thio]-N-(4-methyl-1,2,5-oxadiazol-3-yl)acetamideHomo sapiens (human)Potency35.481310
1-phenyl-4-[[1-(phenylmethyl)-5-tetrazolyl]-(3-pyridinyl)methyl]piperazineHomo sapiens (human)Potency7.079510
1-[(1-cyclopentyl-5-tetrazolyl)-thiophen-2-ylmethyl]-4-(2-methoxyphenyl)piperazineHomo sapiens (human)Potency35.481310
cefsulodin sodiumHomo sapiens (human)Potency56.234110
iaa 94Homo sapiens (human)Potency29.092910
N-[4-(4-fluorophenyl)-2-thiazolyl]-2-[(4-methylphenyl)sulfonylamino]benzamideHomo sapiens (human)Potency25.118910
methamilane methiodideHomo sapiens (human)Potency31.622810
N-[5-(ethylthio)-1,3,4-thiadiazol-2-yl]-3,3,3-trifluoro-2-methyl-2-(trifluoromethyl)propanamideHomo sapiens (human)Potency19.952610
N-[5-(ethylthio)-1,3,4-thiadiazol-2-yl]-2,2-bis(trifluoromethyl)butanamideHomo sapiens (human)Potency17.782810
5-bromo-3-ethyl-1H-indole-2-carboxylic acidHomo sapiens (human)Potency35.481310
N-(3-methoxyphenyl)-5-oxo-6,7-dihydro-[1,2,4]triazolo[3,4-b][1,3]thiazine-7-carboxamideHomo sapiens (human)Potency35.481310
1-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-yl)ethanolHomo sapiens (human)Potency22.387210
1-(2,1,3-benzoxadiazol-4-yloxy)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)-2-butanoneHomo sapiens (human)Potency35.481310
1-[1-(3-fluorophenyl)-2,5-dioxo-3-pyrrolidinyl]-4-piperidinecarboxamideHomo sapiens (human)Potency35.481310
N-[2-[5-[(2,4-dichlorophenyl)methylsulfonyl]-1,3,4-oxadiazol-2-yl]ethyl]carbamic acid tert-butyl esterHomo sapiens (human)Potency10.000010
5-(3-chlorophenyl)-N-[2-methyl-5-(3-methyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl)phenyl]-2-furancarboxamideHomo sapiens (human)Potency4.466810
dienestrolHomo sapiens (human)Potency7.079510
4-cyclohexyl-3-[(3-methylphenoxy)methyl]-1H-1,2,4-triazole-5-thioneHomo sapiens (human)Potency31.622810
3,4-methylenedioxy-beta-nitrostyreneHomo sapiens (human)Potency5.804810
(e)-3-(4-t-butylphenyl)-n-(2,3-dihydrobenzo(b)(1,4)dioxin-6-yl)acrylamideHomo sapiens (human)Potency8.199510
sch-202676Homo sapiens (human)Potency22.272010
4-methoxy-N-(3-pyridinylmethyl)benzamideHomo sapiens (human)Potency19.952610
3-(4-methylbenzoyl)acrylic acidHomo sapiens (human)Potency3.162310
N4-(3-chlorophenyl)-6-methyl-N2-(phenylmethyl)pyrimidine-2,4-diamineHomo sapiens (human)Potency14.125410
n-phenyl-n'-2-pyridylthioureaHomo sapiens (human)Potency14.125410
4-chloro-1-methyl-3-nitro-2-quinolinoneHomo sapiens (human)Potency5.623410
4-[(4-chloro-5-dithiazolylidene)amino]benzonitrileHomo sapiens (human)Potency7.843510
4-chloro-N-(3,4,5-trimethoxyphenyl)-5-dithiazolimineHomo sapiens (human)Potency2.818410
10-methyl-3-phenothiazinamineHomo sapiens (human)Potency10.000010
vu0038882Homo sapiens (human)Potency2.238710
2-(thiophen-2-ylmethylidene)indene-1,3-dioneHomo sapiens (human)Potency3.162310
N-[4-(3,4-dimethylphenyl)-2-thiazolyl]-2-furancarboxamideHomo sapiens (human)Potency8.912510
5-amino-3-(4-methoxyphenyl)-7-methyl-4-oxo-1-thieno[3,4-d]pyridazinecarboxylic acid methyl esterHomo sapiens (human)Potency35.481310
1-(4-methoxyphenyl)-3-(4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)ureaHomo sapiens (human)Potency12.589310
2,4,6-trimethyl-n-(meta-3-trifluoromethylphenyl)benzenesulfonamideHomo sapiens (human)Potency35.481310
1-(3-nitrophenyl)-3-phenyl-2-propyn-1-oneHomo sapiens (human)Potency3.162310
N-[4-(2-methyl-4-thiazolyl)phenyl]benzamideHomo sapiens (human)Potency7.943310
5-ethyl-3-[[4-(2-methylpropoxy)phenyl]methylthio]-1H-1,2,4-triazoleHomo sapiens (human)Potency10.000010
4-chloro-1-ethyl-3-nitro-2-quinolinoneHomo sapiens (human)Potency3.981110
3,5-dimethyl-1-[(7-methyl-2-naphthalenyl)sulfonyl]pyrazoleHomo sapiens (human)Potency11.220210
5-(4-chlorophenyl)-2-furanpropionic acidHomo sapiens (human)Potency35.481310
N-(4-fluorophenyl)-3,4-dihydro-1H-isoquinoline-2-carboxamideHomo sapiens (human)Potency5.623410
N-(4-methylphenyl)carbamic acid (cyclopentylideneamino) esterHomo sapiens (human)Potency10.000010
4-[(4-chlorophenyl)thio]-5-methyl-2-phenyl-1H-pyrazol-3-oneHomo sapiens (human)Potency22.387210
N-(4-methoxyphenyl)-3-methyl-1,3-benzothiazol-2-imineHomo sapiens (human)Potency6.309610
4-chloro-3-ethoxy-N-(4-ethylphenyl)benzenesulfonamideHomo sapiens (human)Potency35.481310
5-methyl-1-phenyl-4-pyrazolecarboxylic acid (4-methoxyphenyl) esterHomo sapiens (human)Potency3.548110
6-amino-2-mercaptobenzothiazoleHomo sapiens (human)Potency8.912510
n-phenyl-n'-3-hydroxyphenylthioureaHomo sapiens (human)Potency31.622810
5-(3,3-dimethyl-2-oxobutoxy)-4-ethyl-7-methyl-1-benzopyran-2-oneHomo sapiens (human)Potency3.548110
2-(4-chlorophenyl)-N-[(2-hydroxy-5-methylanilino)-sulfanylidenemethyl]acetamideHomo sapiens (human)Potency5.623410
7,8-dichloropyrido[1,2-a]benzimidazoleHomo sapiens (human)Potency7.079510
N-[5-[(4-chlorophenoxy)methyl]-1,3,4-thiadiazol-2-yl]-2-furancarboxamideHomo sapiens (human)Potency19.952610
curcuminHomo sapiens (human)Potency18.854110
4-(2-naphthalenyloxymethyl)-2-thiazolamineHomo sapiens (human)Potency12.589310
1-(4-bromophenyl)-3-(2-fluorophenyl)thioureaHomo sapiens (human)Potency11.220210
1-(3,4-dichlorophenyl)-3-(3,5-dimethylphenyl)thioureaHomo sapiens (human)Potency35.481310
2,3,5,6-tetramethyl-N-(2-methyl-1,3-benzothiazol-5-yl)benzenesulfonamideHomo sapiens (human)Potency31.622810
2-[(1,5-diphenyl-2-imidazolyl)thio]-N-(2-furanylmethyl)acetamideHomo sapiens (human)Potency12.589310
3-(n-benzylsulfamoyl)-4-bromo-n-(4-bromophenyl)benzamideHomo sapiens (human)Potency0.562310
2-[2-oxo-2-(2,2,4,6-tetramethyl-1-quinolinyl)ethyl]isoindole-1,3-dioneHomo sapiens (human)Potency10.000010
n-(1,3-benzothiazol-2-yl)-n-(4,5-dihydro-1h-imidazol-2-yl)amineHomo sapiens (human)Potency19.952610
N'-[2-(4-bromo-2-methylphenoxy)-1-oxoethyl]-2-pyrazinecarbohydrazideHomo sapiens (human)Potency22.387210
2-[[(5-ethyl-2-thiophenyl)-oxomethyl]amino]-4-methyl-5-thiazolecarboxylic acid ethyl esterHomo sapiens (human)Potency5.623410
N-(5-tert-butyl-2-methoxyphenyl)-3,5-dimethyl-4-isoxazolecarboxamideHomo sapiens (human)Potency35.481310
N-[5-[(4-chlorophenoxy)methyl]-1,3,4-thiadiazol-2-yl]-5-methyl-3-phenyl-4-isoxazolecarboxamideHomo sapiens (human)Potency6.309610
darunavir ethanolateHomo sapiens (human)Potency15.848910
1-(4-bromophenyl)-3-(3-methylbutyl)thioureaHomo sapiens (human)Potency15.848910
N-[[5-(1H-benzimidazol-2-yl)-2-methylanilino]-sulfanylidenemethyl]-5-chloro-2-methoxybenzamideHomo sapiens (human)Potency10.000010
N-[3-(1,3-benzothiazol-2-ylthio)-4-hydroxyphenyl]-4-chlorobenzenesulfonamideHomo sapiens (human)Potency35.481310
2-[(3-bromo-2-imidazo[1,2-a]pyrimidinyl)methylthio]-1,3-benzothiazoleHomo sapiens (human)Potency19.952610
2-[[[5-(5,6-dimethyl-1H-benzimidazol-2-yl)-2-pyridinyl]thio]methyl]benzonitrileHomo sapiens (human)Potency10.000010
8,9-dimethyl-N-(3-methylphenyl)-3-[2-(4-morpholinyl)ethyl]-4H-[1,3]thiazino[6,5-b]quinolin-2-imineHomo sapiens (human)Potency35.481310
2-[(2-tert-butyl-4-quinazolinyl)thio]-N-(4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)acetamideHomo sapiens (human)Potency7.943310
5-tert-butyl-N-[2-(cyclopentylamino)-2-oxoethyl]-N-(2,5-dimethylphenyl)-3-methyl-2-furancarboxamideHomo sapiens (human)Potency35.481310
4-chloro-N-(4-chloro-2-methylphenyl)-5-dithiazolimineHomo sapiens (human)Potency2.818410
4-[(2-chloro-5-thiazolyl)methylthio]benzoic acidHomo sapiens (human)Potency7.079510
N,N-dimethylcarbamic acid [4-[2-(4-fluorophenyl)sulfonyl-1-oxoethyl]-2,6-dimethylphenyl] esterHomo sapiens (human)Potency15.848910
(4-chlorophenyl)-[4-[[(2,4-dichlorophenyl)thio]methyl]-4-hydroxy-1-piperidinyl]methanoneHomo sapiens (human)Potency17.782810
6-fluoro-2-phenyl-1,2-benzothiazol-3-oneHomo sapiens (human)Potency35.481310
6-fluoro-2-(2-methylphenyl)-1,2-benzothiazol-3-oneHomo sapiens (human)Potency11.220210
2-chloro-1-[1-(2-furanylmethyl)-2,5-dimethyl-3-pyrrolyl]ethanoneHomo sapiens (human)Potency12.589310
enclomipheneHomo sapiens (human)Potency31.622810
n-(fluorenyl-9-methoxycarbonyl)leucineHomo sapiens (human)Potency15.848910
4-methyl-N-[(1-oxopentylhydrazo)-sulfanylidenemethyl]benzamideHomo sapiens (human)Potency3.548110
5-[diethylamino(oxo)methyl]-4-methyl-2-(1-oxopentylamino)-3-thiophenecarboxylic acid methyl esterHomo sapiens (human)Potency11.220210
N-[[[2-(2-methoxyphenoxy)-1-oxoethyl]hydrazo]-sulfanylidenemethyl]-2-furancarboxamideHomo sapiens (human)Potency2.511910
N-[[[(2-methylphenyl)-oxomethyl]hydrazo]-sulfanylidenemethyl]benzamideHomo sapiens (human)Potency4.466810
3-(3-hydroxypropylamino)-7-methyl-1-(pentylamino)-6,8-dihydro-5H-2,7-naphthyridine-4-carbonitrileHomo sapiens (human)Potency3.548110
2-amino-4-[[2-(4-bromophenyl)-2-oxoethyl]thio]-3-azaspiro[5.5]undeca-1,4-diene-1,5-dicarbonitrileHomo sapiens (human)Potency35.481310
N-bis(2-fluorophenoxy)phosphoryl-3,4-dimethylanilineHomo sapiens (human)Potency25.118910
5-methyl-3-[(4-pentoxyphenyl)methylthio]-1H-1,2,4-triazoleHomo sapiens (human)Potency3.548110
N-(4,5-diphenyl-2-oxazolyl)-3-methoxybenzamideHomo sapiens (human)Potency31.622810
N-[2-(3,4-dimethoxyphenyl)ethyl]-8-ethoxy-5H-pyrimido[5,4-b]indol-4-amineHomo sapiens (human)Potency31.622810
3-(1-benzotriazolylmethyl)-6-phenyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoleHomo sapiens (human)Potency22.387210
2-tert-butyl-4-[(4-chlorophenyl)thio]-5-methyl-1H-pyrazol-3-oneHomo sapiens (human)Potency6.309610
N-(5-cyclopropyl-1,3,4-oxadiazol-2-yl)-4-[(4-methyl-1-piperidinyl)sulfonyl]benzamideHomo sapiens (human)Potency17.782810
N-(5-tert-butyl-2-phenyl-3-pyrazolyl)-2-[(6-methyl-1H-benzimidazol-2-yl)thio]acetamideHomo sapiens (human)Potency5.623410
N-(5-cyclopropyl-1,3,4-thiadiazol-2-yl)-2,5-diphenyl-3-pyrazolecarboxamideHomo sapiens (human)Potency7.943310
2-chloro-N-(2-phenyl-5-propyl-3-pyrazolyl)acetamideHomo sapiens (human)Potency35.481310
2-methyl-3-[oxo(thiophen-2-yl)methyl]-1-indolizinecarboxaldehydeHomo sapiens (human)Potency11.220210
6-[1-oxo-2-[[4-(phenylmethyl)-5-thiophen-2-yl-1,2,4-triazol-3-yl]thio]ethyl]-4H-1,4-benzoxazin-3-oneHomo sapiens (human)Potency6.309610
N-[3-(6-methyl-4-phenyl-2-quinolinyl)phenyl]methanesulfonamideHomo sapiens (human)Potency10.000010
4-(dipropylsulfamoyl)-N-[5-[(methylthio)methyl]-1,3,4-oxadiazol-2-yl]benzamideHomo sapiens (human)Potency12.589310
4-[butyl(methyl)sulfamoyl]-N-[5-[(methylthio)methyl]-1,3,4-oxadiazol-2-yl]benzamideHomo sapiens (human)Potency25.118910
4-[ethyl-(phenylmethyl)sulfamoyl]-N-(5-methyl-1,3,4-oxadiazol-2-yl)benzamideHomo sapiens (human)Potency31.622810
1-[2-(2,5-dimethyl-1H-indol-3-yl)ethyl]-3-methyl-1-(thiophen-2-ylmethyl)thioureaHomo sapiens (human)Potency35.481310
thiocyanic acid [2-(1-naphthalenyl)-2-oxoethyl] esterHomo sapiens (human)Potency35.481310
mcb-613Homo sapiens (human)Potency35.481310
4-(benzenesulfonamido)-N-(5-ethyl-1,3,4-thiadiazol-2-yl)benzamideHomo sapiens (human)Potency4.466810
N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-dibenzofuransulfonamideHomo sapiens (human)Potency25.118910
N-(2-fluorophenyl)-4-methoxy-2,5-dimethylbenzenesulfonamideHomo sapiens (human)Potency12.589310
N-[[[(2,4-dichlorophenyl)-oxomethyl]hydrazo]-sulfanylidenemethyl]-2,2-dimethylpropanamideHomo sapiens (human)Potency5.011910
1-[4-(5-fluoro-1,2-benzoxazol-3-yl)-1-piperidinyl]-2-[(4-methyl-2-quinolinyl)thio]ethanoneHomo sapiens (human)Potency15.848910
4-methyl-N-(2-phenylphenyl)-3-(phenylsulfamoyl)benzamideHomo sapiens (human)Potency35.481310
2-[2-[[3-(1,3-benzoxazol-2-yl)anilino]-oxomethyl]phenyl]benzoic acidHomo sapiens (human)Potency3.981110
1,3-dimethyl-5-[[2-[2-(4-nitrophenoxy)ethoxy]phenyl]methylidene]-1,3-diazinane-2,4,6-trioneHomo sapiens (human)Potency35.481310
N-[[(1-oxo-3-phenylpropyl)hydrazo]-sulfanylidenemethyl]pentanamideHomo sapiens (human)Potency5.623410
N-[4-[(4,6-dimethyl-2-pyrimidinyl)sulfamoyl]phenyl]-2-phenyl-4-quinolinecarboxamideHomo sapiens (human)Potency35.481310
2-(4,6-dimethyl-2-pyrimidinyl)-4-[(4-fluorophenyl)thio]-5-methyl-3-pyrazolamineHomo sapiens (human)Potency12.589310
7-methyl-3-(phenylhydrazo)-1,5-benzodiazepin-2-oneHomo sapiens (human)Potency3.548110
3-(4-methoxyphenyl)-N-[[[oxo(pyridin-4-yl)methyl]hydrazo]-sulfanylidenemethyl]-1-phenyl-4-pyrazolecarboxamideHomo sapiens (human)Potency35.481310
2-[4-methyl-3-(1-piperidinylsulfonyl)phenyl]-1,2-benzothiazol-3-oneHomo sapiens (human)Potency10.000010
2-[(5-chloro-2-thiophenyl)sulfonylamino]-N-(2-methoxy-5-methylphenyl)benzamideHomo sapiens (human)Potency2.511910
2-[(1-oxido-2-pyridin-1-iumyl)thio]-1-(4-phenylphenyl)ethanoneHomo sapiens (human)Potency35.481310
N-(5-methyl-1,3,4-thiadiazol-2-yl)-2-quinolinecarboxamideHomo sapiens (human)Potency12.589310
N-[5-[(2,6-dichlorophenyl)methylthio]-1,3,4-thiadiazol-2-yl]-5-methyl-2-pyrazinecarboxamideHomo sapiens (human)Potency22.387210
2-chloro-N-[4-[(3,4-dimethylphenyl)thio]phenyl]acetamideHomo sapiens (human)Potency11.220210
N-(4-tert-butyl-2-thiazolyl)-5-methyl-2-thiophenecarboxamideHomo sapiens (human)Potency19.952610
2-(2,3-dihydro-1H-inden-5-yloxy)-1-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]ethanoneHomo sapiens (human)Potency12.589310
N-(2,3-dihydro-1H-inden-5-yl)-2-[[3-(2-fluorophenyl)-4-oxo-2-quinazolinyl]thio]acetamideHomo sapiens (human)Potency12.589310
3-(1H-indol-3-yl)propanoic acid [2-[tert-butyl-(phenylmethyl)amino]-2-oxoethyl] esterHomo sapiens (human)Potency19.952610
7-[(4-acetylphenoxy)methyl]-5-thiazolo[3,2-a]pyrimidinoneHomo sapiens (human)Potency35.481310
5-chloro-2-mercaptobenzothiazoleHomo sapiens (human)Potency14.125410
benzoylarginine nitroanilideHomo sapiens (human)Potency5.623410
5-(2-chloroanilino)-3-oxo-4-isothiazolecarbonitrileHomo sapiens (human)Potency17.782810
mecysteine hydrochlorideHomo sapiens (human)Potency5.623410
tamoxifen citrateHomo sapiens (human)Potency17.782810
tamoxifenHomo sapiens (human)Potency18.356410
Betaine Aldehyde ChlorideHomo sapiens (human)Potency28.183810
2-[1-[2-oxo-2-[(4-thiophen-2-ylphenyl)methylamino]ethyl]cyclohexyl]acetic acidHomo sapiens (human)Potency14.125410
4-(5-methyl-3-phenylisoxazol-4-yl)pyrimidin-2-amineHomo sapiens (human)Potency3.548110
N-(3-chlorophenyl)-2-[[2-(2-pyridinyl)-2,3-dihydro-1,3,4-thiadiazol-5-yl]thio]acetamideHomo sapiens (human)Potency8.912510
3-[[(2,4-dichlorophenyl)methylthio]methyl]-4-propan-2-yl-1H-1,2,4-triazole-5-thioneHomo sapiens (human)Potency22.387210
statticHomo sapiens (human)Potency20.596210
6-methoxy-3-nitro-2-(phenylsulfonyl)pyridineHomo sapiens (human)Potency35.481310
3-[1-(2,4-dichlorophenyl)sulfonyl-2-pyrrolidinyl]pyridineHomo sapiens (human)Potency22.387210
N'-(4-tert-butyl-2-thiazolyl)-4-chlorobenzohydrazideHomo sapiens (human)Potency17.782810
6-methyl-2-[[(4-methylanilino)-oxomethyl]amino]-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylic acid ethyl esterHomo sapiens (human)Potency35.481310
2-[[(5-tert-butyl-2-methyl-3-furanyl)-oxomethyl]amino]-4,5-dimethoxybenzoic acid methyl esterHomo sapiens (human)Potency5.623410
2-[4-(2-methylpropyl)phenyl]propanoic acid [2-(1H-indol-3-yl)-2-oxoethyl] esterHomo sapiens (human)Potency35.481310
2-(4-pentylphenyl)acetic acidHomo sapiens (human)Potency25.118910
1-(4-bromophenyl)-3-(diethylamino)pyrrolidine-2,5-dioneHomo sapiens (human)Potency25.118910
1-hexadecyl-3-methylimidazolium bromideHomo sapiens (human)Potency10.000010
1-(3,5-dichlorophenyl)-3-(4-morpholinyl)pyrrolidine-2,5-dioneHomo sapiens (human)Potency35.481310
nemadipine-aHomo sapiens (human)Potency29.092910
1-[(4-chlorophenyl)-oxomethyl]-5-hydroxy-5-phenyl-4H-pyrazole-3-carboxylic acid methyl esterHomo sapiens (human)Potency19.952610
2-[[1-(4-ethoxyphenyl)-2,5-dioxo-3-pyrrolidinyl]amino]acetonitrileHomo sapiens (human)Potency35.481310
4-[3-[[(2,5-dichloroanilino)-methyliminomethyl]thio]-2,5-dioxo-1-pyrrolidinyl]benzoic acid methyl esterHomo sapiens (human)Potency17.782810
1-[8-chloro-4-(1-naphthalenyl)-3,3a,4,9b-tetrahydrocyclopenta[c]quinolin-5-yl]ethanoneHomo sapiens (human)Potency35.481310
2-[4-(3,4-dihydro-1H-isoquinolin-2-yl)-4-oxobutyl]benzo[de]isoquinoline-1,3-dioneHomo sapiens (human)Potency17.782810
N-(1-butyl-2-benzimidazolyl)cyclohexanecarboxamideHomo sapiens (human)Potency35.481310
2-[(4-chlorophenyl)thio]-N-[4-[(2,4-dimethylphenyl)sulfamoyl]phenyl]propanamideHomo sapiens (human)Potency35.481310
5-[(3-ethoxycarbonyl-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)amino]-5-oxopentanoic acidHomo sapiens (human)Potency3.162310
3-chloro-N-[3-(1-imidazolyl)propyl]-6-nitro-1-benzothiophene-2-carboxamideHomo sapiens (human)Potency31.622810
2-[[1-(4-methoxy-2-nitrophenyl)-2,5-dioxo-3-pyrrolidinyl]thio]benzoic acidHomo sapiens (human)Potency35.481310
4-[hydroxy(diphenyl)methyl]-N-(2-phenylethyl)-1-piperidinecarbothioamideHomo sapiens (human)Potency17.782810
2-[[[4-[[2-(4-chloro-2-methylphenoxy)-1-oxopropyl]amino]phenyl]-oxomethyl]amino]benzoic acidHomo sapiens (human)Potency22.387210
N-(5-chloro-2-hydroxyphenyl)-2-ethoxybenzamideHomo sapiens (human)Potency11.220210
4-[[2-(4-ethyl-3-oxo-2-morpholinyl)-1-oxoethyl]amino]benzoic acid ethyl esterHomo sapiens (human)Potency17.782810
3-(5-chloro-2-hydroxyphenyl)-3-phenyl-N-[(4-propan-2-yloxyphenyl)methyl]propanamideHomo sapiens (human)Potency35.481310
5-chloro-7-[3-pyridinyl-(2-pyridinylamino)methyl]-8-quinolinolHomo sapiens (human)Potency17.782810
N-(3-carbamoyl-5-propyl-2-thiophenyl)-2-oxolanecarboxamideHomo sapiens (human)Potency31.622810
[3-(2-hydroxyphenyl)-5-phenyl-3,4-dihydropyrazol-2-yl]-phenylmethanoneHomo sapiens (human)Potency35.481310
4-[[3-[(4-chlorophenyl)sulfonylamino]-2-quinoxalinyl]amino]-1-piperidinecarboxylic acid ethyl esterHomo sapiens (human)Potency14.125410
1-(4-methoxy-2-nitrophenyl)-4-(5,6,7,8-tetrahydronaphthalen-2-ylsulfonyl)piperazineHomo sapiens (human)Potency3.981110
cb 7969312Homo sapiens (human)Potency35.481310
1-(2-methoxy-5-methylphenyl)-5-(2-oxanylmethylthio)tetrazoleHomo sapiens (human)Potency35.481310
2-[(3-butan-2-yl-4-oxo-2-quinazolinyl)thio]propanenitrileHomo sapiens (human)Potency33.552010
2-[2-(2,5-dimethyl-1-phenyl-3-pyrrolyl)-2-oxoethyl]-3a,4,7,7a-tetrahydroisoindole-1,3-dioneHomo sapiens (human)Potency0.562310
2-acetylpyridine-(4-phenylthiosemicarbazone)Homo sapiens (human)Potency7.079510
LSM-1318Homo sapiens (human)Potency10.329810
zuclomifene citrateHomo sapiens (human)Potency35.481310
omephineHomo sapiens (human)Potency12.589310
N-[[2-(4-chlorophenyl)-1,3-dioxo-7,7a-dihydro-3aH-octahydro-1H-4,7-epoxyisoindol-4-yl]methyl]benzenesulfonamideHomo sapiens (human)Potency35.481310
(3-bromophenyl)-[5-(4-bromophenyl)-3-ethyl-5-hydroxy-4H-pyrazol-1-yl]methanoneHomo sapiens (human)Potency14.125410
2-[(3-cyano-4,6-diphenyl-2-pyridinyl)thio]-3-methylbutanoic acidHomo sapiens (human)Potency31.622810
N-[[5-[(4-chlorophenyl)methylthio]-4-phenyl-1,2,4-triazol-3-yl]methyl]-4-ethoxyanilineHomo sapiens (human)Potency22.387210
3-nitro-N-[(1-oxopentylhydrazo)-sulfanylidenemethyl]benzamideHomo sapiens (human)Potency17.782810
1,6-dimethyl-3-propylpyrimido[5,4-e][1,2,4]triazine-5,7-dioneHomo sapiens (human)Potency35.481310
[4-(2,7-dimethyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)-1-piperazinyl]-(2-furanyl)methanoneHomo sapiens (human)Potency11.220210
2-chloro-N-[1-[oxo(10-phenothiazinyl)methyl]-4-piperidinyl]benzamideHomo sapiens (human)Potency19.952610
N-[5-(ethylthio)-1,3,4-thiadiazol-2-yl]-2-[[3-(2-methoxyphenyl)-4-oxo-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl]thio]acetamideHomo sapiens (human)Potency5.623410
5-ethyl-N-[2-(2-phenyl-4-thiazolyl)ethyl]-2-thiophenesulfonamideHomo sapiens (human)Potency31.622810
4-[[2-(3-ethylanilino)-3,4-dioxo-1-cyclobutenyl]amino]-1-piperidinecarboxylic acid ethyl esterHomo sapiens (human)Potency6.309610
2-(3-phenyl-1-indazolyl)acetic acid methyl esterHomo sapiens (human)Potency0.316210
5-(4-chlorophenyl)-N-(2-furanylmethyl)-3-isoxazolecarboxamideHomo sapiens (human)Potency0.562310
5-nitro-2-thiophenecarboxylic acid [2-oxo-2-(1-phenylethylamino)ethyl] esterHomo sapiens (human)Potency12.589310
2-phenoxy-N-[5-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,4-oxadiazol-2-yl]acetamideHomo sapiens (human)Potency10.000010
1-(3,4-dichlorophenyl)-3-[1-(4-morpholinyl)-1-phenylpropan-2-yl]ureaHomo sapiens (human)Potency14.125410
ro 41-0960Homo sapiens (human)Potency20.596210
4-(3,4-dihydro-2H-quinolin-1-ylsulfonyl)-N-(5-ethyl-1,3,4-oxadiazol-2-yl)benzamideHomo sapiens (human)Potency3.162310
1-(4-methoxyphenyl)-3-(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)pyrrolidine-2,5-dioneHomo sapiens (human)Potency2.818410
N-(4-fluorophenyl)-2-(3-methyl-5-oxo-1-phenyl-4H-pyrazol-4-yl)-2-oxoacetamideHomo sapiens (human)Potency10.000010
7-(5-bromo-2-fluorophenyl)-5-(4-bromophenyl)-1,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidineHomo sapiens (human)Potency35.481310
N-[5-(2,3-dihydro-1,4-dioxin-5-yl)-1,3,4-oxadiazol-2-yl]-5-nitro-2-thiophenecarboxamideHomo sapiens (human)Potency10.000010
sb 242084Homo sapiens (human)Potency29.092910
2-[8-bromo-7-[(2-chlorophenyl)methyl]-3-methyl-2,6-dioxo-1-purinyl]acetic acid methyl esterHomo sapiens (human)Potency10.000010
2-[4-[3-(4-methoxyphenyl)-1H-pyrazol-5-yl]-1-piperidinyl]-3-nitropyridineHomo sapiens (human)Potency14.125410
3-methyl-N-[[[(4-nitrophenyl)-oxomethyl]hydrazo]-sulfanylidenemethyl]butanamideHomo sapiens (human)Potency3.981110
N-[2-(3-methyl-1-oxobutyl)-3-oxo-1,2,4-thiadiazol-5-yl]benzamideHomo sapiens (human)Potency22.387210
1-(4-chlorophenyl)-3-[2-(2-furanylmethyl)cyclohexyl]ureaHomo sapiens (human)Potency35.481310
2-(1H-benzimidazol-2-yl)-5-methyl-4-(phenylmethyl)-4H-pyrazol-3-oneHomo sapiens (human)Potency15.848910
1-(2-fluorophenyl)-3-(N-(phenylmethyl)anilino)thioureaHomo sapiens (human)Potency35.481310
1-(3,3-dimethylbutan-2-yl)-3-[3-(trifluoromethyl)phenyl]thioureaHomo sapiens (human)Potency35.481310
2-[(2,2-dichloro-3,3-dimethylcyclopropyl)methylthio]-1H-benzimidazoleHomo sapiens (human)Potency31.622810
3-chloro-N-[5-(3-pyridinyl)-1,3,4-oxadiazol-2-yl]benzamideHomo sapiens (human)Potency17.782810
N-(5-cyclopropyl-1,3,4-oxadiazol-2-yl)-4-[(3-methyl-1-piperidinyl)sulfonyl]benzamideHomo sapiens (human)Potency31.622810
N-[4-[(1,2-dimethyl-5-indolyl)methylsulfamoyl]phenyl]acetamideHomo sapiens (human)Potency5.011910
2-chloro-N-[5-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,4-oxadiazol-2-yl]benzamideHomo sapiens (human)Potency3.548110
4-chloro-N-(1,3,4-thiadiazol-2-yl)-5-dithiazolimineHomo sapiens (human)Potency19.952610
LSM-16446Homo sapiens (human)Potency5.623410
2,4-dichloro-N-[5-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,4-oxadiazol-2-yl]benzamideHomo sapiens (human)Potency5.623410
5-nitro-2-thiophenecarboxylic acid [2-oxo-2-[(phenylmethyl)amino]ethyl] esterHomo sapiens (human)Potency35.481310
1-(2,4-difluorophenyl)-3-[4-(2-pyridinyl)-2-thiazolyl]ureaHomo sapiens (human)Potency8.912510
3-[(2,6-dimethyl-4-morpholinyl)sulfonyl]-N-(5-methyl-2-thiazolyl)benzamideHomo sapiens (human)Potency25.118910
2-[(2-chlorophenyl)methoxy]-N-(4,5-dihydrothiazol-2-yl)benzamideHomo sapiens (human)Potency1.584910
5'-bromo-2'-spiro[1,2-dihydro-4,1,2-benzoxadiazine-3,3'-1H-indole]oneHomo sapiens (human)Potency35.481310
1-(3,4-dichlorophenyl)-3-(1,3,5-trimethyl-4-pyrazolyl)ureaHomo sapiens (human)Potency31.622810
N-[[[2-(2-naphthalenyloxy)-1-oxopropyl]hydrazo]-sulfanylidenemethyl]-2-furancarboxamideHomo sapiens (human)Potency7.079510
LSM-4833Homo sapiens (human)Potency22.387210
N-(4-Nitro-1,2,5-oxadiazol-3-yl)-2-pyridin-2-ylsulfanylacetamideHomo sapiens (human)Potency11.220210
diclofenac sodiumHomo sapiens (human)Potency25.920710
N,N-dimethyl-3-(3-oxo-1,2-benzothiazol-2-yl)benzenesulfonamideHomo sapiens (human)Potency25.118910
2-[(1-methyl-3-indolyl)thio]-1-(4-phenyl-1-piperazinyl)ethanoneHomo sapiens (human)Potency15.848910
5-[(2,4-dichlorophenoxy)methyl]-N-[3,5-dimethyl-1-[(2,3,4,5,6-pentafluorophenyl)methyl]-4-pyrazolyl]-2-furancarboxamideHomo sapiens (human)Potency22.387210
4,5,6,7-tetrabromobenzimidazoleHomo sapiens (human)Potency3.264310
4-[[[[2-(3-pyridinyl)-1-piperidinyl]amino]-sulfanylidenemethyl]amino]benzoic acid methyl esterHomo sapiens (human)Potency15.848910
sib 1757Homo sapiens (human)Potency12.857810
dibutyl maleateHomo sapiens (human)Potency31.622810
morusinHomo sapiens (human)Potency17.782810
trans-2,3',4,5'-tetrahydroxystilbeneHomo sapiens (human)Potency14.125410
Pinosylvin methyl etherHomo sapiens (human)Potency28.183810
caffeic acid phenethyl esterHomo sapiens (human)Potency4.167910
Licarin AHomo sapiens (human)Potency7.943310
tectochrysinHomo sapiens (human)Potency6.309610
n-oleoyldopamineHomo sapiens (human)Potency30.357810
perhexiline maleateHomo sapiens (human)Potency4.466810
sirolimusHomo sapiens (human)Potency3.981110
as 604850Homo sapiens (human)Potency8.199510
2-[[2-(3,4-dimethoxyphenyl)-5-methyl-4-oxazolyl]methylsulfinyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)acetamideHomo sapiens (human)Potency5.623410
N,N-dicyclohexyl-5-propyl-3-isoxazolecarboxamideHomo sapiens (human)Potency5.623410
3-(3,4-dimethoxyphenyl)-5,7-dihydroxy-2-methyl-1-benzopyran-4-oneHomo sapiens (human)Potency35.481310
N-(1,3-benzodioxol-5-yl)-2-(5-methyl-2-furanyl)-3-imidazo[1,2-a]pyrazinamineHomo sapiens (human)Potency19.952610
2-[[cyclohexyl(oxo)methyl]amino]-3-thiophenecarboxamideHomo sapiens (human)Potency11.220210
esomeprazole magnesiumHomo sapiens (human)Potency35.481310
bornyl ferulateHomo sapiens (human)Potency22.387210
crenulatin coumarinHomo sapiens (human)Potency31.622810
muromonab-cd3Homo sapiens (human)Potency35.481310
tyrphostin b44Homo sapiens (human)Potency35.481310
4-[4-(4-hydroxy-3-methoxyphenyl)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]-2-methoxyphenyl hexopyranosideHomo sapiens (human)Potency17.782810
bay 11-7082Homo sapiens (human)Potency11.582110
bay 11-7085Homo sapiens (human)Potency5.714110
2-(4-(dimethylamino)styryl)benzothiazoleHomo sapiens (human)Potency11.519010
serratinHomo sapiens (human)Potency11.220210
guanabenz acetateHomo sapiens (human)Potency4.466810
methylbenzethonium chlorideHomo sapiens (human)Potency15.848910
quinaldine redHomo sapiens (human)Potency10.000010
3,3'-diethylthiacarbocyanine iodideHomo sapiens (human)Potency10.000010
chloride of pseudoisocyanineHomo sapiens (human)Potency11.220210
5233705 compoundHomo sapiens (human)Potency10.000010
10-hydroxy-3-methyl-8-pentyl-2,4-dihydro-1H-[1]benzopyrano[3,4-c]pyridin-5-oneHomo sapiens (human)Potency35.481310
6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2h-pyran-2-oneHomo sapiens (human)Potency5.173510
Adenosine 5'-monophosphate monohydrateHomo sapiens (human)Potency3.162310
enclomiphene citrateHomo sapiens (human)Potency14.125410
lasalocid sodiumHomo sapiens (human)Potency35.481310
sclerotiorinHomo sapiens (human)Potency10.000010
4-hydroxyderricinHomo sapiens (human)Potency35.481310
su 4312Homo sapiens (human)Potency35.481310
l-165041Homo sapiens (human)Potency22.470910
cycloheximideHomo sapiens (human)Potency3.548110
granisetron hydrochlorideHomo sapiens (human)Potency5.011910
edelfosineHomo sapiens (human)Potency29.092910
altenusinHomo sapiens (human)Potency14.125410
13-epi-sclareolHomo sapiens (human)Potency19.952610
N-[(2-chlorophenyl)methyl]-2-[7-oxo-3-(phenylmethyl)-6-triazolo[4,5-d]pyrimidinyl]acetamideHomo sapiens (human)Potency5.623410
N-[4-(1-adamantylsulfamoyl)phenyl]-4-bromo-1-methyl-3-pyrazolecarboxamideHomo sapiens (human)Potency15.848910
chlorhexidineHomo sapiens (human)Potency15.848910
aldicarb sulfoxideHomo sapiens (human)Potency35.481310
17-cyclopropylmethyl-6,7-didehydro-4,5-epoxy-5'-guanidinyl-3,14-dihydroxyindolo(2',3'-6,7)morphinanHomo sapiens (human)Potency5.804810
lissamine rhodamine bHomo sapiens (human)Potency7.943310
NNC 55-0396 (free base)Homo sapiens (human)Potency31.622810
levodopa methyl ester hydrochlorideHomo sapiens (human)Potency35.481310
teferinHomo sapiens (human)Potency35.481310
((2-n-butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1h-inden-5-yl)oxy)acetic acid, (+)-isomerHomo sapiens (human)Potency19.373610
uncarine cHomo sapiens (human)Potency25.118910
(5R)-9-bromo-5-phenyl-3-prop-2-enyl-1,2,4,5-tetrahydro-3-benzazepine-7,8-diolHomo sapiens (human)Potency23.109310
2-(4-methoxyphenyl)-1,2-benzothiazol-3-oneHomo sapiens (human)Potency35.481310
2-(4-chlorophenyl)-1,2-benzothiazol-3-oneHomo sapiens (human)Potency31.622810
N(2)-([biphenyl]-4-ylsulfonyl)-N-hydroxy-N(2)-isopropoxy-D-valinamideHomo sapiens (human)Potency16.360110
glabrolHomo sapiens (human)Potency22.387210
N-[(1,3-dioxo-2-phenyl-7,7a-dihydro-3aH-octahydro-1H-4,7-epoxyisoindol-4-yl)methyl]-4-methylbenzenesulfonamideHomo sapiens (human)Potency35.481310
2-(2,1,3-benzothiadiazol-4-ylsulfonyl)-5-(4-bromophenyl)-3-pyrazolamineHomo sapiens (human)Potency15.848910
b 015Homo sapiens (human)Potency6.513110
calcimycinHomo sapiens (human)Potency6.513110
(2R,3S)-EHNA hydrochlorideHomo sapiens (human)Potency3.548110
4-methylpyrazole monohydrochlorideHomo sapiens (human)Potency19.952610
1-(4-fluorophenyl)-3-[[2-(4-methylphenyl)-1,3-dioxo-7,7a-dihydro-3aH-octahydro-1H-4,7-epoxyisoindol-4-yl]methyl]thioureaHomo sapiens (human)Potency12.589310
1-(4-methylphenyl)-3-[[2-(4-methylphenyl)-1,3-dioxo-7,7a-dihydro-3aH-octahydro-1H-4,7-epoxyisoindol-4-yl]methyl]thioureaHomo sapiens (human)Potency25.118910
1-(3-chlorophenyl)-3-[[2-(4-methylphenyl)-1,3-dioxo-7,7a-dihydro-3aH-octahydro-1H-4,7-epoxyisoindol-4-yl]methyl]thioureaHomo sapiens (human)Potency25.118910
chlorhexidine hydrochlorideHomo sapiens (human)Potency28.183810
(R)-Bitalin AHomo sapiens (human)Potency25.118910
2-(3-chlorophenyl)-1,2-benzothiazol-3-oneHomo sapiens (human)Potency35.481310
[3-methyl-4-(3-methylphenyl)-1-piperazinyl]-[1-(7,8,9,10-tetrahydro-6H-purino[9,8-a]azepin-4-yl)-4-piperidinyl]methanoneHomo sapiens (human)Potency28.183810
tanninsHomo sapiens (human)Potency11.220210
N-[2-(3,4-dimethoxyphenyl)ethyl]-2-[3-(4-fluorophenyl)-2,4-dioxo-1-thieno[3,2-d]pyrimidinyl]acetamideHomo sapiens (human)Potency0.562310
1-[(1-ethyl-3,4-dihydro-2H-quinolin-6-yl)methyl]-3-(3-methoxyphenyl)-1-[2-(4-morpholinyl)ethyl]thioureaHomo sapiens (human)Potency5.623410
N-[[2-(4-methylphenyl)-1,3-dioxo-7,7a-dihydro-3aH-octahydro-1H-4,7-epoxyisoindol-4-yl]methyl]-4-phenyl-1-piperazinecarbothioamideHomo sapiens (human)Potency11.220210
[5-(4-bromophenyl)-3-(2-hydroxyphenyl)-3,4-dihydropyrazol-2-yl]-pyridin-4-ylmethanoneHomo sapiens (human)Potency12.589310
xi-3-Hydroxy-5-phenylpentanoic acid O-beta-D-GlucopyranosideHomo sapiens (human)Potency5.623410
(5S)-1-(4-cyclohexylbutyl)-5-phenyl-4,5-dihydroimidazol-2-amineHomo sapiens (human)Potency35.481310
(5R)-1-[2-[3,5-bis(trifluoromethyl)phenyl]ethyl]-5-butyl-4,5-dihydroimidazol-2-amineHomo sapiens (human)Potency14.125410
thimerosalHomo sapiens (human)Potency0.707910
2-[[[4-[(4-chloroanilino)-oxomethyl]-1H-imidazol-5-yl]-oxomethyl]amino]acetic acid tert-butyl esterHomo sapiens (human)Potency35.481310
1-(2,3-Dihydro-1,4-benzodioxin-3-ylmethyl)-5-methoxy-isatinHomo sapiens (human)Potency35.481310
5-[[4-(4-acetylphenyl)-1-piperazinyl]sulfonyl]-1,3-dihydroindol-2-oneHomo sapiens (human)Potency5.623410
5-fluoro-2-phenyl-1,2-benzothiazol-3-oneHomo sapiens (human)Potency35.481310
2-(2-fluorophenyl)-1,2-benzothiazol-3-oneHomo sapiens (human)Potency35.481310
2-(4-fluorophenyl)-1,2-benzothiazol-3-oneHomo sapiens (human)Potency35.481310
3-[1-[[1-(4-chlorophenyl)cyclopropyl]-oxomethyl]-4-piperidinyl]-5-phenyl-1,3,4-oxadiazol-2-oneHomo sapiens (human)Potency25.118910
acid blue 129Homo sapiens (human)Potency22.387210
sodium 2,6-dichloroindophenolHomo sapiens (human)Potency35.481310
2-[(6-chloro-3-pyridinyl)sulfonylamino]-N-[(4-methylphenyl)methyl]benzamideHomo sapiens (human)Potency35.481310
4-[[3-(4-chlorophenyl)-5-isoxazolyl]methyl]-1-[(2-methylpropan-2-yl)oxy-oxomethyl]-4-piperidinecarboxylic acidHomo sapiens (human)Potency35.481310
4-chloro-N-(5-methyl-1,3,4-oxadiazol-2-yl)-5-dithiazolimineHomo sapiens (human)Potency3.162310
4-[3-(3-methylphenyl)-5-phenyl-3,4-dihydropyrazol-2-yl]benzenesulfonamideHomo sapiens (human)Potency22.387210
4-[3-(3-bromophenyl)-5-phenyl-3,4-dihydropyrazol-2-yl]benzenesulfonamideHomo sapiens (human)Potency22.387210
2-[5-[(3,4-dichlorophenyl)methylthio]-4-(2-furanylmethyl)-1,2,4-triazol-3-yl]pyridineHomo sapiens (human)Potency5.623410
1-(3-aminopropyl)-3-[3-[(5-bromo-2-pyridinyl)-[(4-chlorophenyl)methyl]amino]propyl]thioureaHomo sapiens (human)Potency35.481310
1-[4-[(5-bromo-2-pyridinyl)-[(4-chlorophenyl)methyl]amino]butyl]-3-[3-(1H-imidazol-5-yl)propyl]thioureaHomo sapiens (human)Potency19.952610
sphaeropsidin aHomo sapiens (human)Potency1.995310
1-butyl-4-hydroxy-N-(3-methyl-2-pyridinyl)-2-oxo-3-quinolinecarboxamideHomo sapiens (human)Potency19.952610
piroxicamHomo sapiens (human)Potency5.804810
4,7-Dihydroxy-2H-1-benzopyran-2-oneHomo sapiens (human)Potency22.387210
N-(1H-benzimidazol-2-yl)-1-ethyl-4-hydroxy-2-oxo-3-quinolinecarboxamideHomo sapiens (human)Potency19.952610
a 1062Homo sapiens (human)Potency7.943310
folic acidHomo sapiens (human)Potency3.981110
1-hydroxyphenazineHomo sapiens (human)Potency22.387210
2-pyridin-4-yl-1H-quinazolin-4-oneHomo sapiens (human)Potency22.387210
tegaserod maleateHomo sapiens (human)Potency35.481310
ag-879Homo sapiens (human)Potency11.582110
N-[(4-oxo-1H-quinazolin-2-yl)methyl]-N-(2-phenylethyl)butanamideHomo sapiens (human)Potency14.125410
2-[(7-methoxy-4-methyl-2-quinazolinyl)amino]-5,6-dimethyl-1H-pyrimidin-4-oneHomo sapiens (human)Potency35.481310
5-(4-chlorophenyl)-3-(4-nitrophenyl)-1H-pyrazoleHomo sapiens (human)Potency31.622810

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
gallic acidHomo sapiens (human)IC504.430011
hypericinHomo sapiens (human)IC507.500011
vitamin k 3Homo sapiens (human)IC5015.000011
masoprocolHomo sapiens (human)IC500.215022
estriolHomo sapiens (human)IC5020.100011
estroneHomo sapiens (human)IC5093.100011
androstenedioneHomo sapiens (human)IC5085.900011
phenothiazineHomo sapiens (human)IC5026.000011
phenothiazineHomo sapiens (human)Ki0.500011
1,4-naphthoquinoneHomo sapiens (human)IC5015.000011
selegilineHomo sapiens (human)IC500.270011
bromocriptineHomo sapiens (human)IC5024.700011
pergolideHomo sapiens (human)IC507.900011
coomassie brilliant blue rHomo sapiens (human)IC50322.000011
gallocatecholHomo sapiens (human)IC508.900011
delphinidinHomo sapiens (human)IC506.500011
epicatechinHomo sapiens (human)IC5015.350022
gallocatecholHomo sapiens (human)IC5010.600011
epicatechin gallateHomo sapiens (human)IC509.800011
procyanidin b2Homo sapiens (human)IC504.300011
(-)-gallocatechin gallateHomo sapiens (human)IC503.600011
tretinoinHomo sapiens (human)IC503.000011
retinolHomo sapiens (human)IC500.190011
ferulic acidHomo sapiens (human)IC500.750011
retinaldehydeHomo sapiens (human)IC500.190011
curcuminHomo sapiens (human)IC5081.010022
quercetinHomo sapiens (human)IC5020.000011
luteolinHomo sapiens (human)IC5028.000011
baicaleinHomo sapiens (human)IC508.200011
myricetinHomo sapiens (human)IC506.760022
rosmarinic acidHomo sapiens (human)IC500.210011
menatetrenoneHomo sapiens (human)IC5015.000011
vitamin k 1Homo sapiens (human)IC5015.000011
(-)-catechin-3-O-gallateHomo sapiens (human)IC5021.400011
su 4312Homo sapiens (human)Ki0.084411
procyanidin b1Homo sapiens (human)IC507.300011
tetracyclineHomo sapiens (human)IC506.060011
rifampinHomo sapiens (human)IC5026.650022
hydrazinocurcuminHomo sapiens (human)IC50126.800011

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
thioflavin tHomo sapiens (human)Kd15.200011
curcuminHomo sapiens (human)Kd3.500044
ceftriaxoneHomo sapiens (human)Kd0.530011
3-(1,3-benzodioxol-5-yl)-5-(3-bromophenyl)-1h-pyrazoleHomo sapiens (human)Kd0.190011

Enables

This protein enables 24 target(s):

TargetCategoryDefinition
SNARE bindingmolecular functionBinding to a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein. [PMID:12642621]
magnesium ion bindingmolecular functionBinding to a magnesium (Mg) ion. [GOC:ai]
transcription cis-regulatory region bindingmolecular functionBinding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. [GOC:txnOH]
actin bindingmolecular functionBinding to monomeric or multimeric forms of actin, including actin filaments. [GOC:clt]
protein kinase inhibitor activitymolecular functionBinds to and stops, prevents or reduces the activity of a protein kinase. [GOC:ai]
copper ion bindingmolecular functionBinding to a copper (Cu) ion. [GOC:ai]
calcium ion bindingmolecular functionBinding to a calcium ion (Ca2+). [GOC:ai]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
phospholipid bindingmolecular functionBinding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester. [ISBN:0198506732]
ferrous iron bindingmolecular functionBinding to a ferrous iron ion, Fe(II). [GOC:ai]
zinc ion bindingmolecular functionBinding to a zinc ion (Zn). [GOC:ai]
lipid bindingmolecular functionBinding to a lipid. [GOC:ai]
oxidoreductase activitymolecular functionCatalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. [GOC:go_curators]
kinesin bindingmolecular functionInteracting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation. [GOC:curators, PMID:8606779]
Hsp70 protein bindingmolecular functionBinding to a Hsp70 protein, heat shock proteins around 70kDa in size. [ISBN:0198506732]
histone bindingmolecular functionBinding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription. [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]
identical protein bindingmolecular functionBinding to an identical protein or proteins. [GOC:jl]
alpha-tubulin bindingmolecular functionBinding to the microtubule constituent protein alpha-tubulin. [GOC:jl]
cysteine-type endopeptidase inhibitor activity involved in apoptotic processmolecular functionBinds to and stops, prevents or reduces the activity of a cysteine-type endopeptidase involved in the apoptotic process. [GOC:jl, GOC:mtg_apoptosis, PMID:14744432, Wikipedia:Caspase]
tau protein bindingmolecular functionBinding to tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS. [GOC:jid]
phosphoprotein bindingmolecular functionBinding to a phosphorylated protein. [GOC:ai]
molecular adaptor activitymolecular functionThe binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way. [GOC:mtg_MIT_16mar07, GOC:vw]
dynein complex bindingmolecular functionBinding to a dynein complex, a protein complex that contains two or three dynein heavy chains and several light chains, and has microtubule motor activity. [GOC:bf, GOC:BHF, GOC:mah]
cuprous ion bindingmolecular functionBinding to a cuprous ion, copper(1+). [GO_REF:0000067, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24567322]

Located In

This protein is located in 18 target(s):

TargetCategoryDefinition
extracellular regioncellular componentThe space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators]
extracellular spacecellular componentThat part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684]
nucleuscellular componentA membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
cytoplasmcellular componentThe contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
mitochondrioncellular componentA semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732]
lysosomecellular componentA small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. [GOC:mah, ISBN:0198506732]
cytosolcellular componentThe part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
cell cortexcellular componentThe region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. [GOC:mah, ISBN:0815316194]
actin cytoskeletoncellular componentThe part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. [GOC:jl, ISBN:0395825172, ISBN:0815316194]
membranecellular componentA lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
inclusion bodycellular componentA discrete intracellular part formed of aggregated molecules such as proteins or other biopolymers. [GOC:mah, PMID:11121744]
axoncellular componentThe long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. [GOC:nln, ISBN:0198506732]
growth conecellular componentThe migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic. [GOC:aruk, GOC:bc, ISBN:0815316194, PMID:10082468]
synaptic vesicle membranecellular componentThe lipid bilayer surrounding a synaptic vesicle. [GOC:mah]
perinuclear region of cytoplasmcellular componentCytoplasm situated near, or occurring around, the nucleus. [GOC:jid]
postsynapsecellular componentThe part of a synapse that is part of the post-synaptic cell. [GOC:dos]
supramolecular fibercellular componentA polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure. [GOC:dos]

Active In

This protein is active in 3 target(s):

TargetCategoryDefinition
cytoplasmcellular componentThe contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
axon terminuscellular componentTerminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it. [GOC:dph, GOC:jl]
neuronal cell bodycellular componentThe portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. [GOC:go_curators]

Part Of

This protein is part of 1 target(s):

TargetCategoryDefinition
protein-containing complexcellular componentA stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. [GOC:dos, GOC:mah]

Involved In

This protein is involved in 76 target(s):

TargetCategoryDefinition
negative regulation of transcription by RNA polymerase IIbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]
microglial cell activationbiological processThe change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. [GOC:mgi_curators, PMID:10626665, PMID:10695728, PMID:12580336, PMID:9893949]
positive regulation of receptor recyclingbiological processAny process that activates or increases the frequency, rate or extent of receptor recycling. [GOC:add]
positive regulation of neurotransmitter secretionbiological processAny process that activates or increases the frequency, rate or extent of the regulated release of a neurotransmitter. [GOC:hjd]
negative regulation of protein kinase activitybiological processAny process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity. [GOC:go_curators]
fatty acid metabolic processbiological processThe chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. [ISBN:0198547684]
neutral lipid metabolic processbiological processThe chemical reactions and pathways involving neutral lipids, lipids only soluble in solvents of very low polarity. [ISBN:0198547684]
phospholipid metabolic processbiological processThe chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester. [ISBN:0198506732]
activation of cysteine-type endopeptidase activity involved in apoptotic processbiological processAny process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process. [GOC:al, GOC:dph, GOC:jl, GOC:mtg_apoptosis, GOC:tb, PMID:14744432, PMID:18328827, Wikipedia:Caspase]
mitochondrial membrane organizationbiological processA process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrial membrane, either of the lipid bilayer surrounding a mitochondrion. [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
adult locomotory behaviorbiological processLocomotory behavior in a fully developed and mature organism. [GOC:ai]
response to xenobiotic stimulusbiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:jl, GOC:krc]
response to iron(II) ionbiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron(II) ion stimulus. [GOC:sm]
regulation of phospholipase activitybiological processAny process that modulates the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid. [GOC:BHF, GOC:dph, GOC:tb]
negative regulation of platelet-derived growth factor receptor signaling pathwaybiological processAny process that stops, prevents, or reduces the frequency, rate or extent of the platelet-derived growth factor receptor signaling pathway. [GOC:dph, GOC:hjd, GOC:tb]
regulation of glutamate secretionbiological processAny process that modulates the frequency, rate or extent of the controlled release of glutamate. [GOC:ef]
regulation of dopamine secretionbiological processAny process that modulates the frequency, rate or extent of the regulated release of dopamine. [GOC:ef]
synaptic vesicle exocytosisbiological processFusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft. [GOC:jid, GOC:lmg]
synaptic vesicle primingbiological processA process that converts synaptic vesicles to a state of competence for calcium triggered fusion with the active zone membrane by bringing the two membranes into very close proximity. Priming typically (but not always) occurs after docking (Jahn and Fasshauer, 2012). Primed vesicles are also capable of spontaneously fusing with the active zone membrane. [GOC:mah, PMID:15217342, PMID:23060190]
regulation of transmembrane transporter activitybiological processAny process that modulates the frequency, rate or extent of transmembrane transporter activity. [GOC:dph, GOC:mtg_cardio, GOC:mtg_transport]
negative regulation of microtubule polymerizationbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization. [GOC:mah]
receptor internalizationbiological processA receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane. [GOC:bf, GOC:mah, GOC:signaling, PMID:15006537, PMID:19643732]
protein destabilizationbiological processAny process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation. [GOC:mah]
response to magnesium ionbiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnesium ion stimulus. [GOC:mah]
negative regulation of transporter activitybiological processAny process that stops or reduces the activity of a transporter. [GOC:mah]
response to lipopolysaccharidebiological processAny process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria. [GOC:add, ISBN:0721601464]
negative regulation of monooxygenase activitybiological processAny process that stops or reduces the activity of a monooxygenase. [GOC:mah]
positive regulation of peptidyl-serine phosphorylationbiological processAny process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine. [GOC:mah]
response to type II interferonbiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon-gamma is also known as type II interferon. [GOC:add, ISBN:0126896631, PMID:15546383]
cellular response to oxidative stressbiological processAny process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. [GOC:mah]
SNARE complex assemblybiological processThe aggregation, arrangement and bonding together of a set of components to form a SNARE complex, a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. [GOC:rb, PMID:10872468]
positive regulation of SNARE complex assemblybiological processAny process that increases the frequency, rate or extent of assembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. [GOC:rb]
regulation of locomotionbiological processAny process that modulates the frequency, rate or extent of locomotion of a cell or organism. [GOC:ems]
dopamine biosynthetic processbiological processThe chemical reactions and pathways resulting in the formation of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline. [GOC:jl, ISBN:0198506732]
mitochondrial ATP synthesis coupled electron transportbiological processThe transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane or chloroplast thylakoid membrane. [GOC:mtg_sensu, ISBN:0716731363]
regulation of macrophage activationbiological processAny process that modulates the frequency or rate of macrophage activation. [GOC:jl]
positive regulation of apoptotic processbiological processAny process that activates or increases the frequency, rate or extent of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis]
negative regulation of apoptotic processbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis]
negative regulation of cysteine-type endopeptidase activity involved in apoptotic processbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process. [GOC:jl, GOC:mtg_apoptosis]
negative regulation of neuron apoptotic processbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons. [GOC:go_curators, GOC:mtg_apoptosis]
positive regulation of endocytosisbiological processAny process that activates or increases the frequency, rate or extent of endocytosis. [GOC:go_curators]
negative regulation of exocytosisbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of exocytosis. [GOC:go_curators]
positive regulation of exocytosisbiological processAny process that activates or increases the frequency, rate or extent of exocytosis. [GOC:go_curators]
regulation of long-term neuronal synaptic plasticitybiological processA process that modulates long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers. [GOC:jid, PMID:11891290]
synaptic vesicle endocytosisbiological processA vesicle-mediated transport process, in which the synaptic vesicle membrane constituents are retrieved from the presynaptic membrane on the axon terminal after neurotransmitter secretion by exocytosis. Synaptic vesicle endocytosis can occur via clathrin-dependent and clathrin-independent mechanisms. [GOC:aruk, GOC:bc, GOC:jid, GOC:lmg, GOC:mah, PMID:20448150, PMID:26430111]
synaptic vesicle transportbiological processThe directed movement of synaptic vesicles. [GOC:aruk, GOC:bc, GOC:jid, GOC:lmg, GOC:pr]
positive regulation of inflammatory responsebiological processAny process that activates or increases the frequency, rate or extent of the inflammatory response. [GOC:ai]
regulation of acyl-CoA biosynthetic processbiological processAny process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of acyl-CoA. [GOC:ai]
protein tetramerizationbiological processThe formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits. [GOC:ecd]
positive regulation of release of sequestered calcium ion into cytosolbiological processAny process that activates or increases the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria. [GOC:ai]
neuron apoptotic processbiological processAny apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system. [CL:0000540, GOC:mtg_apoptosis]
dopamine uptake involved in synaptic transmissionbiological processThe directed movement of dopamine into a presynaptic neuron or glial cell. In this context, dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline. [GOC:ai]
negative regulation of dopamine uptake involved in synaptic transmissionbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of dopamine into a presynaptic neuron or glial cell. [GOC:ai]
negative regulation of serotonin uptakebiological processAny process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of serotonin into a cell. [GOC:ai]
regulation of norepinephrine uptakebiological processAny process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter norepinephrine into a cell. [GOC:ai]
negative regulation of norepinephrine uptakebiological processAny process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of norepinephrine into a cell. [GOC:ai]
excitatory postsynaptic potentialbiological processA process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential. [GOC:dph, GOC:ef]
long-term synaptic potentiationbiological processA process that modulates synaptic plasticity such that synapses are changed resulting in the increase in the rate, or frequency of synaptic transmission at the synapse. [GOC:dgh, GOC:dph]
positive regulation of inositol phosphate biosynthetic processbiological processAny process that increases the rate, frequency or extent of inositol phosphate biosynthesis. Inositol phosphate biosynthetic processes are the chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached. [GOC:dph, GOC:tb]
negative regulation of thrombin-activated receptor signaling pathwaybiological processAny process that stops, prevents, or reduces the frequency, rate or extent of thrombin-activated receptor protein signaling pathway activity. A thrombin receptor signaling pathway is the series of molecular signals generated as a consequence of a thrombin-activated receptor binding to one of its physiological ligands. [GOC:mah]
response to interleukin-1biological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus. [GOC:BHF, GOC:mah]
cellular response to copper ionbiological processAny process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus. [GOC:mah]
cellular response to epinephrine stimulusbiological processAny process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epinephrine stimulus. Epinephrine is a catecholamine that has the formula C9H13NO3; it is secreted by the adrenal medulla to act as a hormone, and released by certain neurons to act as a neurotransmitter active in the central nervous system. [GOC:BHF, GOC:mah]
positive regulation of protein serine/threonine kinase activitybiological processAny process that increases the rate, frequency, or extent of protein serine/threonine kinase activity. [GOC:mah]
supramolecular fiber organizationbiological processA process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a supramolecular fiber, a polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure. [GOC:pr]
negative regulation of mitochondrial electron transport, NADH to ubiquinonebiological processAny process that stops, prevents or reduces the frequency, rate or extent of mitochondrial electron transport, NADH to ubiquinone. [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:23530063]
positive regulation of glutathione peroxidase activitybiological processAny process that activates or increases the frequency, rate or extent of glutathione peroxidase activity. [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23507046]
positive regulation of hydrogen peroxide catabolic processbiological processAny process that activates or increases the frequency, rate or extent of hydrogen peroxide catabolic process. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23507046]
regulation of synaptic vesicle recyclingbiological processAny process that modulates the frequency, rate or extent of synaptic vesicle recycling. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22745285]
regulation of reactive oxygen species biosynthetic processbiological processAny process that modulates the frequency, rate or extent of reactive oxygen species biosynthetic process. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804]
positive regulation of protein localization to cell peripherybiological processAny process that activates or increases the frequency, rate or extent of protein localization to cell periphery. [GO_REF:0000058, GOC:TermGenie, PMID:18216290]
negative regulation of chaperone-mediated autophagybiological processAny process that stops, prevents or reduces the frequency, rate or extent of chaperone-mediated autophagy. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20176123]
regulation of presynapse assemblybiological processAny process that modulates the frequency, rate or extent of presynapse assembly. [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:25533483]
amyloid fibril formationbiological processThe generation of amyloid fibrils, insoluble fibrous protein aggregates exhibiting beta sheet structure, from proteins. [GOC:cvs, GOC:jj, GOC:ppm, GOC:sj, PMID:21148556, PMID:22817896, PMID:28937655, PMID:29654159]
synapse organizationbiological processA process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). [GOC:ai, GOC:pr]
chemical synaptic transmissionbiological processThe vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. [GOC:jl, MeSH:D009435]