Retinoic acid receptor gamma

A retinoic acid receptor gamma that is encoded in the genome of human. [PRO:DNx, UniProtKB:P13631]

Synonyms

RAR-gamma;
Nuclear receptor subfamily 1 group B member 3

Research

Bioassay Publications (44)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	18 (40.91)	18.2507
2000's	18 (40.91)	29.6817
2010's	8 (18.18)	24.3611
2020's	0 (0.00)	2.80

Compounds (34)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
lg 100268	Homo sapiens (human)	Ki	9.9505	2	2
adapalene	Homo sapiens (human)	Ki	0.1300	1	1
bexarotene	Homo sapiens (human)	Ki	1.6680	2	2
4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthracenyl)benzoic acid	Homo sapiens (human)	Ki	0.0020	1	1
cd 437	Homo sapiens (human)	Ki	0.0770	1	1
6-(1,2,3,4-tetrahydro-1,1,4,4-tetramethyl-6-naphthyl)-2-naphthalenecarboxylic acid	Homo sapiens (human)	Ki	0.0400	1	1
cd 2019	Homo sapiens (human)	Ki	0.1600	1	1
agn 193109	Homo sapiens (human)	IC50	0.0030	1	1
tretinoin	Homo sapiens (human)	IC50	0.0064	3	3
tretinoin	Homo sapiens (human)	Ki	0.0056	4	4
bms 195614	Homo sapiens (human)	Ki	0.0018	1	2
bms 961	Homo sapiens (human)	Ki	0.0015	1	1
alitretinoin	Homo sapiens (human)	IC50	0.0170	1	1
alitretinoin	Homo sapiens (human)	Ki	0.0105	2	2
clothiapine	Homo sapiens (human)	Ki	10.0000	1	1
lg 100567	Homo sapiens (human)	Ki	0.0630	1	2
fenretinide	Homo sapiens (human)	Ki	0.4000	1	1
4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid	Homo sapiens (human)	IC50	0.0260	1	1
4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid	Homo sapiens (human)	Ki	0.0050	1	1
pregna-4,17-diene-3,16-dione	Homo sapiens (human)	IC50	100.0000	1	1
lg100754	Homo sapiens (human)	Ki	6.0940	1	1
lg 1506	Homo sapiens (human)	Ki	9.8377	3	3
bms453	Homo sapiens (human)	Ki	0.0173	1	1

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
am 580	Homo sapiens (human)	EC50	0.0190	3	3
am 580	Homo sapiens (human)	Kd	3.8120	2	2
bms 961	Homo sapiens (human)	EC50	0.0510	1	1
tazarotene	Homo sapiens (human)	EC50	0.0400	1	1
adapalene	Homo sapiens (human)	EC50	0.0031	1	1
bexarotene	Homo sapiens (human)	EC50	6.8827	3	3
bexarotene	Homo sapiens (human)	Kd	1.0000	1	1
tamibarotene	Homo sapiens (human)	EC50	0.5910	1	1
cd 437	Homo sapiens (human)	EC50	0.0490	1	1
agn 193109	Homo sapiens (human)	Kd	0.0053	3	3
tretinoin	Homo sapiens (human)	EC50	0.0116	16	16
tretinoin	Homo sapiens (human)	Kd	0.0103	12	14
bms 961	Homo sapiens (human)	Kd	0.5280	1	1
alitretinoin	Homo sapiens (human)	EC50	0.0302	8	8
alitretinoin	Homo sapiens (human)	Kd	0.0640	5	7
lg 100567	Homo sapiens (human)	EC50	0.0082	1	2
4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid	Homo sapiens (human)	EC50	0.0095	3	3
4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid	Homo sapiens (human)	Kd	0.0260	1	1
agn 191659	Homo sapiens (human)	EC50	0.0370	1	1
agn 191701	Homo sapiens (human)	EC50	0.0000	1	1
pregna-4,17-diene-3,16-dione	Homo sapiens (human)	EC50	100.0000	1	1
agn 190121	Homo sapiens (human)	EC50	0.0100	1	1
agn 190121	Homo sapiens (human)	Kd	0.1900	1	1
lg100754	Homo sapiens (human)	EC50	0.1920	1	1
nrx 194204	Homo sapiens (human)	Kd	15.0150	2	2
agn 194204	Homo sapiens (human)	Kd	15.9000	1	1
sr 11302	Homo sapiens (human)	EC50	1.0000	1	1
cd 666	Homo sapiens (human)	EC50	0.0460	1	1
cd 666	Homo sapiens (human)	Kd	1.5360	1	3
agn 190205	Homo sapiens (human)	EC50	0.0006	1	1
ac 261066	Homo sapiens (human)	EC50	0.5012	1	1

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
am 580	Homo sapiens (human)	EC30	0.0330	1	1
tamibarotene	Homo sapiens (human)	EC30	0.1500	1	1
6-(1,2,3,4-tetrahydro-1,1,4,4-tetramethyl-6-naphthyl)-2-naphthalenecarboxylic acid	Homo sapiens (human)	AC50	0.0680	1	1
tretinoin	Homo sapiens (human)	EC30	0.0002	2	2
tretinoin	Homo sapiens (human)	Relative EC30	0.0006	2	2
tretinoin	Homo sapiens (human)	Relative IC50	0.0007	2	2
alitretinoin	Homo sapiens (human)	AC50	0.0030	1	1
sr 11217	Homo sapiens (human)	AC50	1.0000	1	1
4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid	Homo sapiens (human)	AC50	0.0260	1	1
bms453	Homo sapiens (human)	Kb	0.0185	1	1

Enables

This protein enables 10 target(s):

Target	Category	Definition
DNA-binding transcription factor activity, RNA polymerase II-specific	molecular function	A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. [GOC:txnOH-2018]
DNA binding	molecular function	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
chromatin binding	molecular function	Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. [GOC:jl, ISBN:0198506732, PMID:20404130]
DNA-binding transcription factor activity	molecular function	A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. [GOC:txnOH-2018]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
zinc ion binding	molecular function	Binding to a zinc ion (Zn). [GOC:ai]
nuclear retinoid X receptor binding	molecular function	Binding to a nuclear retinoid X receptor. [GOC:ai]
sequence-specific double-stranded DNA binding	molecular function	Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding. [GOC:dos, GOC:sl]
nuclear receptor activity	molecular function	A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytosol, which leads to its translocation to the nucleus. [GOC:txnOH-2018, PMID:23457262]
RNA polymerase II cis-regulatory region sequence-specific DNA binding	molecular function	Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. [GOC:txnOH-2018]

Located In

This protein is located in 4 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]

Part Of

This protein is part of 2 target(s):

Target	Category	Definition
chromatin	cellular component	The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. [GOC:elh, PMID:20404130]
transcription regulator complex	cellular component	A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription. [GOC:jl]

Involved In

This protein is involved in 33 target(s):

Target	Category	Definition
negative regulation of transcription by RNA polymerase II	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]
neural tube closure	biological process	The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline. [GOC:dph, ISBN:0878932437]
glandular epithelial cell development	biological process	The process whose specific outcome is the progression of a glandular epithelial cell over time, from its formation to the mature structure. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland. [GOC:dph]
growth plate cartilage chondrocyte growth	biological process	The growth of a growth plate cartilage chondrocyte, where growth contributes to the progression of the chondrocyte over time from one condition to another. [GOC:ascb_2009, GOC:dph, GOC:tb]
apoptotic process	biological process	A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
positive regulation of cell population proliferation	biological process	Any process that activates or increases the rate or extent of cell proliferation. [GOC:go_curators]
negative regulation of cell population proliferation	biological process	Any process that stops, prevents or reduces the rate or extent of cell proliferation. [GOC:go_curators]
regulation of cell size	biological process	Any process that modulates the size of a cell. [GOC:go_curators]
anterior/posterior pattern specification	biological process	The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism. [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb]
positive regulation of gene expression	biological process	Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). [GOC:txnOH-2018]
embryonic camera-type eye development	biological process	The process occurring during the embryonic phase whose specific outcome is the progression of the eye over time, from its formation to the mature structure. [GOC:mah, GOC:mtg_sensu]
regulation of myelination	biological process	Any process that modulates the frequency, rate or extent of the formation of a myelin sheath around nerve axons. [GOC:mah]
negative regulation of chondrocyte differentiation	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of chondrocyte differentiation. [GOC:mah]
response to retinoic acid	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus. [GOC:sl]
embryonic hindlimb morphogenesis	biological process	The process, occurring in the embryo, by which the anatomical structures of the hindlimbs are generated and organized. The hindlimbs are the posterior limbs of an animal. [ISBN:0198612001]
multicellular organism growth	biological process	The increase in size or mass of an entire multicellular organism, as opposed to cell growth. [GOC:bf, GOC:curators, GOC:dph, GOC:tb]
positive regulation of apoptotic process	biological process	Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis]
positive regulation of programmed cell death	biological process	Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes. [GOC:jl]
regulation of myeloid cell differentiation	biological process	Any process that modulates the frequency, rate or extent of myeloid cell differentiation. [GOC:go_curators]
positive regulation of transcription by RNA polymerase II	biological process	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. [GOC:go_curators, GOC:txnOH]
embryonic eye morphogenesis	biological process	The process occurring in the embryo by which the anatomical structures of the post-embryonic eye are generated and organized. [GOC:jid]
retinoic acid receptor signaling pathway	biological process	The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands. [GOC:dgh]
canonical Wnt signaling pathway	biological process	A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes. [PMID:11532397, PMID:19619488]
face development	biological process	The biological process whose specific outcome is the progression of a face from an initial condition to its mature state. The face is the ventral division of the head. [GOC:dph]
trachea cartilage development	biological process	The process whose specific outcome is the progression of the tracheal cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. [GOC:dph]
prostate gland epithelium morphogenesis	biological process	The process in which the anatomical structures of epithelia of the prostate gland are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube. [GOC:dph]
Harderian gland development	biological process	The process whose specific outcome is the progression of the Harderian gland over time, from its formation to the mature structure. The Harderian gland is an anterior orbital structure usually associated with the nictitating membrane, and produces and secretes a variety of substances to the eye, depending upon the species. [GOC:hjd, PMID:16856596, PMID:7559104]
cellular response to retinoic acid	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus. [GOC:mah]
stem cell proliferation	biological process	The multiplication or reproduction of stem cells, resulting in the expansion of a stem cell population. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. [GOC:mtg_kidney_jan10]
cellular response to leukemia inhibitory factor	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukemia inhibitory factor stimulus. [PMID:12801913]
negative regulation of stem cell proliferation	biological process	Any process that stops, prevents or reduces the frequency, rate or extent of stem cell proliferation. [GOC:dph]
cell differentiation	biological process	The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. [ISBN:0198506732]
hormone-mediated signaling pathway	biological process	The series of molecular signals mediated by the detection of a hormone. [GOC:sm]