Proteins > Sucrase-isomaltase, intestinal
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Sucrase-isomaltase, intestinal
A sucrase-isomaltase, intestinal that is encoded in the genome of rat. [OMA:P23739, PRO:DNx]
Synonyms
Research
Bioassay Publications (33)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (12.12) | 18.2507 |
| 2000's | 8 (24.24) | 29.6817 |
| 2010's | 18 (54.55) | 24.3611 |
| 2020's | 3 (9.09) | 2.80 |
Compounds (34)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| pyrogallol | Rattus norvegicus (Norway rat) | IC50 | 500.0000 | 1 | 1 |
| catechin | Rattus norvegicus (Norway rat) | IC50 | 310.0000 | 1 | 1 |
| 1-deoxynojirimycin | Rattus norvegicus (Norway rat) | IC50 | 0.3479 | 14 | 14 |
| acarbose | Rattus norvegicus (Norway rat) | IC50 | 20.2000 | 1 | 1 |
| miglustat | Rattus norvegicus (Norway rat) | IC50 | 18.1114 | 7 | 7 |
| ursolic acid | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 1 |
| 1-deoxymannojirimycin | Rattus norvegicus (Norway rat) | IC50 | 110.0000 | 1 | 1 |
| fagomine | Rattus norvegicus (Norway rat) | IC50 | 133.4000 | 5 | 5 |
| epicatechin | Rattus norvegicus (Norway rat) | IC50 | 650.0000 | 1 | 1 |
| mor-14 | Rattus norvegicus (Norway rat) | IC50 | 2.2200 | 2 | 2 |
| 2,5-dihydroxymethyl-3,4-dihydroxypyrrolidine | Rattus norvegicus (Norway rat) | IC50 | 111.6667 | 6 | 6 |
| 1,4-dideoxy-1,4-iminoarabinitol | Rattus norvegicus (Norway rat) | IC50 | 0.8286 | 7 | 7 |
| procyanidin b3 | Rattus norvegicus (Norway rat) | IC50 | 430.0000 | 1 | 1 |
| homonojirimycin | Rattus norvegicus (Norway rat) | IC50 | 0.4350 | 2 | 2 |
| valiolamine | Rattus norvegicus (Norway rat) | IC50 | 1.3950 | 2 | 2 |
| miglitol | Rattus norvegicus (Norway rat) | IC50 | 12.6340 | 10 | 10 |
| ao 128 | Rattus norvegicus (Norway rat) | IC50 | 1.6760 | 15 | 15 |
| acarbose | Rattus norvegicus (Norway rat) | IC50 | 79.7578 | 18 | 18 |
| 2,5-dideoxy-2,5-imino-d-glucitol | Rattus norvegicus (Norway rat) | IC50 | 617.5000 | 4 | 4 |
| resveratrol | Rattus norvegicus (Norway rat) | IC50 | 400.0000 | 1 | 1 |
| 1,4-dideoxy-1,4-iminoarabinitol, (2r-(2alpha,3beta,4beta))-isomer | Rattus norvegicus (Norway rat) | IC50 | 56.0000 | 2 | 2 |
| isofagomine | Rattus norvegicus (Norway rat) | IC50 | 410.5000 | 2 | 2 |
| 1,4-dideoxy-1,4-imino-d-arabinitol | Rattus norvegicus (Norway rat) | IC50 | 15.5000 | 9 | 9 |
| caffeic acid | Rattus norvegicus (Norway rat) | IC50 | 87.4500 | 1 | 1 |
| baicalein | Rattus norvegicus (Norway rat) | IC50 | 156.0000 | 2 | 2 |
| polydatin | Rattus norvegicus (Norway rat) | IC50 | 400.0000 | 1 | 1 |
| salacinol | Rattus norvegicus (Norway rat) | IC50 | 1.9387 | 15 | 15 |
| salacinol | Rattus norvegicus (Norway rat) | Ki | 0.6500 | 2 | 2 |
| vaticanol b | Rattus norvegicus (Norway rat) | IC50 | 294.0000 | 1 | 1 |
| 3-epi-fagomine | Rattus norvegicus (Norway rat) | IC50 | 6.0000 | 1 | 1 |
| ponkoranol | Rattus norvegicus (Norway rat) | IC50 | 34.2967 | 3 | 3 |
| kotalanol | Rattus norvegicus (Norway rat) | IC50 | 3.1500 | 8 | 8 |
| kotalanol | Rattus norvegicus (Norway rat) | Ki | 2.3100 | 2 | 2 |
| neosalacinol | Rattus norvegicus (Norway rat) | IC50 | 2.7200 | 7 | 7 |
| malibatol a | Rattus norvegicus (Norway rat) | IC50 | 231.0000 | 1 | 1 |
| vaticanol c | Rattus norvegicus (Norway rat) | IC50 | 94.2000 | 1 | 1 |
Synthesis and glycosidase inhibition of 5-C-alkyl-DNJ and 5-C-alkyl-l-ido-DNJ derivatives.European journal of medicinal chemistry, , Nov-15, Volume: 224, 2021
α-1-C-butyl-1,4-dideoxy-1,4-imino-l-arabinitol as a second-generation iminosugar-based oral α-glucosidase inhibitor for improving postprandial hyperglycemia.Journal of medicinal chemistry, , Dec-13, Volume: 55, Issue:23, 2012
Docking and SAR studies of D- and L-isofagomine isomers as human β-glucocerebrosidase inhibitors.Bioorganic & medicinal chemistry, , Jun-01, Volume: 19, Issue:11, 2011
In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures.Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
Biological properties of D- and L-1-deoxyazasugars.Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
Alpha-1-C-alkyl-1-deoxynojirimycin derivatives as potent and selective inhibitors of intestinal isomaltase: remarkable effect of the alkyl chain length on glycosidase inhibitory profile.Bioorganic & medicinal chemistry letters, , Dec-20, Volume: 14, Issue:24, 2004
N-alkylated nitrogen-in-the-ring sugars: conformational basis of inhibition of glycosidases and HIV-1 replication.Journal of medicinal chemistry, , Jun-23, Volume: 38, Issue:13, 1995
α-1-C-butyl-1,4-dideoxy-1,4-imino-l-arabinitol as a second-generation iminosugar-based oral α-glucosidase inhibitor for improving postprandial hyperglycemia.Journal of medicinal chemistry, , Dec-13, Volume: 55, Issue:23, 2012
Alpha-1-C-alkyl-1-deoxynojirimycin derivatives as potent and selective inhibitors of intestinal isomaltase: remarkable effect of the alkyl chain length on glycosidase inhibitory profile.Bioorganic & medicinal chemistry letters, , Dec-20, Volume: 14, Issue:24, 2004
N-alkylated nitrogen-in-the-ring sugars: conformational basis of inhibition of glycosidases and HIV-1 replication.Journal of medicinal chemistry, , Jun-23, Volume: 38, Issue:13, 1995
Docking and SAR studies of D- and L-isofagomine isomers as human β-glucocerebrosidase inhibitors.Bioorganic & medicinal chemistry, , Jun-01, Volume: 19, Issue:11, 2011
In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures.Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
Fagomine isomers and glycosides from Xanthocercis zambesiaca.Journal of natural products, , Volume: 60, Issue:3, 1997
Effect of five-membered sugar mimics on mammalian glycogen-degrading enzymes and various glucosidases.Bioorganic & medicinal chemistry, , Mar-15, Volume: 16, Issue:6, 2008
Nitrogen-containing furanose and pyranose analogues from Hyacinthus orientalis.Journal of natural products, , Volume: 61, Issue:5, 1998
N-alkylated nitrogen-in-the-ring sugars: conformational basis of inhibition of glycosidases and HIV-1 replication.Journal of medicinal chemistry, , Jun-23, Volume: 38, Issue:13, 1995
Design, synthesis and glycosidase inhibition of C-4 branched LAB and DAB derivatives.European journal of medicinal chemistry, , Apr-05, Volume: 233, 2022
α-1-C-butyl-1,4-dideoxy-1,4-imino-l-arabinitol as a second-generation iminosugar-based oral α-glucosidase inhibitor for improving postprandial hyperglycemia.Journal of medicinal chemistry, , Dec-13, Volume: 55, Issue:23, 2012
Effect of five-membered sugar mimics on mammalian glycogen-degrading enzymes and various glucosidases.Bioorganic & medicinal chemistry, , Mar-15, Volume: 16, Issue:6, 2008
Hydrophobic substituents increase the potency of salacinol, a potent α-glucosidase inhibitor from Ayurvedic traditional medicine 'Salacia'.Bioorganic & medicinal chemistry, , 08-15, Volume: 24, Issue:16, 2016
Synthesis and biological evaluation of α-1-C-4'-arylbutyl-L-arabinoiminofuranoses, a new class of α-glucosidase inhibitors.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 24, Issue:15, 2014
α-1-C-butyl-1,4-dideoxy-1,4-imino-l-arabinitol as a second-generation iminosugar-based oral α-glucosidase inhibitor for improving postprandial hyperglycemia.Journal of medicinal chemistry, , Dec-13, Volume: 55, Issue:23, 2012
The synthesis and biological evaluation of 1-C-alkyl-L-arabinoiminofuranoses, a novel class of α-glucosidase inhibitors.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures.Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
Design, synthesis and biological evaluation of 3'-benzylated analogs of 3'-epi-neoponkoranol as potent α-glucosidase inhibitors.European journal of medicinal chemistry, , Mar-03, Volume: 110, 2016
Synthesis and biological evaluation of α-1-C-4'-arylbutyl-L-arabinoiminofuranoses, a new class of α-glucosidase inhibitors.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 24, Issue:15, 2014
α-1-C-butyl-1,4-dideoxy-1,4-imino-l-arabinitol as a second-generation iminosugar-based oral α-glucosidase inhibitor for improving postprandial hyperglycemia.Journal of medicinal chemistry, , Dec-13, Volume: 55, Issue:23, 2012
Biological evaluation of 3'-O-alkylated analogs of salacinol, the role of hydrophobic alkyl group at 3' position in the side chain on the α-glucosidase inhibitory activity.Bioorganic & medicinal chemistry letters, , May-15, Volume: 21, Issue:10, 2011
Role of the side chain stereochemistry in the α-glucosidase inhibitory activity of kotalanol, a potent natural α-glucosidase inhibitor.Bioorganic & medicinal chemistry, , Apr-01, Volume: 19, Issue:7, 2011
Isolation, structure identification and SAR studies on thiosugar sulfonium salts, neosalaprinol and neoponkoranol, as potent α-glucosidase inhibitors.Bioorganic & medicinal chemistry, , Mar-15, Volume: 19, Issue:6, 2011
The synthesis and biological evaluation of 1-C-alkyl-L-arabinoiminofuranoses, a novel class of α-glucosidase inhibitors.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures.Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
New arylalkanones from Horsfieldia macrobotrys, effective antidiabetic agents concomitantly inhibiting α-glucosidase and free radicals.Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 25, Issue:20, 2015
Synthesis and biological evaluation of α-1-C-4'-arylbutyl-L-arabinoiminofuranoses, a new class of α-glucosidase inhibitors.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 24, Issue:15, 2014
Rat intestinal sucrase inhibition of constituents from the roots of Rosa rugosa Thunb.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 24, Issue:4, 2014
Amine-linked diquercitols as new α-glucosidase inhibitors.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 24, Issue:23, 2014
Quercitylcinnamates, a new series of antidiabetic bioconjugates possessing α-glucosidase inhibition and antioxidant.European journal of medicinal chemistry, , Volume: 66, 2013
Synthesis and α-glucosidase inhibitory activity evaluation of N-substituted aminomethyl-β-d-glucopyranosides.Bioorganic & medicinal chemistry, , Sep-01, Volume: 21, Issue:17, 2013
Antidiabetogenic oligostilbenoids and 3-ethyl-4-phenyl-3,4-dihydroisocoumarins from the bark of Shorea roxburghii.Bioorganic & medicinal chemistry, , Jan-15, Volume: 20, Issue:2, 2012
α-1-C-butyl-1,4-dideoxy-1,4-imino-l-arabinitol as a second-generation iminosugar-based oral α-glucosidase inhibitor for improving postprandial hyperglycemia.Journal of medicinal chemistry, , Dec-13, Volume: 55, Issue:23, 2012
Concise synthesis of (+)-conduritol F and inositol analogues from naturally available (+)-proto-quercitol and their glucosidase inhibitory activity.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 22, Issue:4, 2012
Biological evaluation of 3'-O-alkylated analogs of salacinol, the role of hydrophobic alkyl group at 3' position in the side chain on the α-glucosidase inhibitory activity.Bioorganic & medicinal chemistry letters, , May-15, Volume: 21, Issue:10, 2011
Role of the side chain stereochemistry in the α-glucosidase inhibitory activity of kotalanol, a potent natural α-glucosidase inhibitor.Bioorganic & medicinal chemistry, , Apr-01, Volume: 19, Issue:7, 2011
Isolation, structure identification and SAR studies on thiosugar sulfonium salts, neosalaprinol and neoponkoranol, as potent α-glucosidase inhibitors.Bioorganic & medicinal chemistry, , Mar-15, Volume: 19, Issue:6, 2011
The synthesis and biological evaluation of 1-C-alkyl-L-arabinoiminofuranoses, a novel class of α-glucosidase inhibitors.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures.Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
Design, synthesis and glycosidase inhibition of C-4 branched LAB and DAB derivatives.European journal of medicinal chemistry, , Apr-05, Volume: 233, 2022
trans, trans-2-C-Aryl-3,4-dihydroxypyrrolidines as potent and selective β-glucosidase inhibitors: Pharmacological chaperones for Gaucher disease.European journal of medicinal chemistry, , Aug-05, Volume: 238, 2022
Effect of five-membered sugar mimics on mammalian glycogen-degrading enzymes and various glucosidases.Bioorganic & medicinal chemistry, , Mar-15, Volume: 16, Issue:6, 2008
New sugar-mimic alkaloids from the pods of Angylocalyx pynaertii.Journal of natural products, , Volume: 65, Issue:2, 2002
N-alkylated nitrogen-in-the-ring sugars: conformational basis of inhibition of glycosidases and HIV-1 replication.Journal of medicinal chemistry, , Jun-23, Volume: 38, Issue:13, 1995
2-Aminoresorcinol is a potent alpha-glucosidase inhibitor.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 18, Issue:2, 2008
Baicalein, an alpha-glucosidase inhibitor from Scutellaria baicalensis.Journal of natural products, , Volume: 61, Issue:11, 1998
Hydrophobic substituents increase the potency of salacinol, a potent α-glucosidase inhibitor from Ayurvedic traditional medicine 'Salacia'.Bioorganic & medicinal chemistry, , 08-15, Volume: 24, Issue:16, 2016
Role of the side chain stereochemistry in the α-glucosidase inhibitory activity of kotalanol, a potent natural α-glucosidase inhibitor. Part 2.Bioorganic & medicinal chemistry, , Nov-01, Volume: 20, Issue:21, 2012
Biological evaluation of 3'-O-alkylated analogs of salacinol, the role of hydrophobic alkyl group at 3' position in the side chain on the α-glucosidase inhibitory activity.Bioorganic & medicinal chemistry letters, , May-15, Volume: 21, Issue:10, 2011
Role of the side chain stereochemistry in the α-glucosidase inhibitory activity of kotalanol, a potent natural α-glucosidase inhibitor.Bioorganic & medicinal chemistry, , Apr-01, Volume: 19, Issue:7, 2011
Isolation, structure identification and SAR studies on thiosugar sulfonium salts, neosalaprinol and neoponkoranol, as potent α-glucosidase inhibitors.Bioorganic & medicinal chemistry, , Mar-15, Volume: 19, Issue:6, 2011
Effect of five-membered sugar mimics on mammalian glycogen-degrading enzymes and various glucosidases.Bioorganic & medicinal chemistry, , Mar-15, Volume: 16, Issue:6, 2008
Alpha-glucosidase inhibitor from Kothala-himbutu (Salacia reticulata WIGHT).Journal of natural products, , Volume: 71, Issue:6, 2008
Role of the side chain stereochemistry in the α-glucosidase inhibitory activity of kotalanol, a potent natural α-glucosidase inhibitor.Bioorganic & medicinal chemistry, , Apr-01, Volume: 19, Issue:7, 2011
Isolation, structure identification and SAR studies on thiosugar sulfonium salts, neosalaprinol and neoponkoranol, as potent α-glucosidase inhibitors.Bioorganic & medicinal chemistry, , Mar-15, Volume: 19, Issue:6, 2011
Role of the side chain stereochemistry in the α-glucosidase inhibitory activity of kotalanol, a potent natural α-glucosidase inhibitor. Part 2.Bioorganic & medicinal chemistry, , Nov-01, Volume: 20, Issue:21, 2012
Role of the side chain stereochemistry in the α-glucosidase inhibitory activity of kotalanol, a potent natural α-glucosidase inhibitor.Bioorganic & medicinal chemistry, , Apr-01, Volume: 19, Issue:7, 2011
Isolation, structure identification and SAR studies on thiosugar sulfonium salts, neosalaprinol and neoponkoranol, as potent α-glucosidase inhibitors.Bioorganic & medicinal chemistry, , Mar-15, Volume: 19, Issue:6, 2011
Alpha-glucosidase inhibitor from Kothala-himbutu (Salacia reticulata WIGHT).Journal of natural products, , Volume: 71, Issue:6, 2008
Biological evaluation of 3'-O-alkylated analogs of salacinol, the role of hydrophobic alkyl group at 3' position in the side chain on the α-glucosidase inhibitory activity.Bioorganic & medicinal chemistry letters, , May-15, Volume: 21, Issue:10, 2011
Isolation, structure identification and SAR studies on thiosugar sulfonium salts, neosalaprinol and neoponkoranol, as potent α-glucosidase inhibitors.Bioorganic & medicinal chemistry, , Mar-15, Volume: 19, Issue:6, 2011
Effect of five-membered sugar mimics on mammalian glycogen-degrading enzymes and various glucosidases.Bioorganic & medicinal chemistry, , Mar-15, Volume: 16, Issue:6, 2008