Glucagon-like peptide 1 receptor

A glucagon-like peptide 1 receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P43220]

Synonyms

GLP-1 receptor;
GLP-1-R;
GLP-1R

Research

Bioassay Publications (23)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	5 (21.74)	29.6817
2010's	12 (52.17)	24.3611
2020's	6 (26.09)	2.80

Compounds (5)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
mk-0893	Homo sapiens (human)	IC50	10.0000	1	1
liraglutide	Homo sapiens (human)	IC50	0.0024	2	2
liraglutide	Homo sapiens (human)	Ki	0.0054	2	2
glucagon-like peptide 1	Homo sapiens (human)	IC50	0.0051	5	5
exenatide	Homo sapiens (human)	IC50	0.0023	3	3
exenatide	Homo sapiens (human)	Ki	0.0001	2	2
glucagon-like peptide 1	Homo sapiens (human)	IC50	0.0001	2	2

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
liraglutide	Homo sapiens (human)	EC50	0.0082	9	9
liraglutide	Homo sapiens (human)	Kd	6.2700	1	1
glucagon-like peptide 1	Homo sapiens (human)	EC50	0.0593	16	16
exenatide	Homo sapiens (human)	EC50	0.0526	17	17
glucagon-like peptide 1	Homo sapiens (human)	EC50	0.0000	4	4
glucagon-like peptide 1	Homo sapiens (human)	Kd	0.0005	1	1

Enables

This protein enables 5 target(s):

Target	Category	Definition
transmembrane signaling receptor activity	molecular function	Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction. [GOC:go_curators, Wikipedia:Transmembrane_receptor]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
glucagon-like peptide 1 receptor activity	molecular function	Combining with glucagon-like peptide 1 and transmitting the signal across the membrane by activating an associated G-protein. [GOC:jl, PMID:12529935]
peptide hormone binding	molecular function	Binding to a peptide with hormonal activity in animals. [GOC:jl, ISBN:0198506732]
glucagon receptor activity	molecular function	Combining with glucagon and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:mah, GOC:signaling, PMID:22438981]

Located In

This protein is located in 2 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Involved In

This protein is involved in 13 target(s):

Target	Category	Definition
cell surface receptor signaling pathway	biological process	The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription. [GOC:signaling]
adenylate cyclase-activating G protein-coupled receptor signaling pathway	biological process	A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling. [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]
activation of adenylate cyclase activity	biological process	Any process that initiates the activity of the inactive enzyme adenylate cyclase. [GOC:ai]
positive regulation of cytosolic calcium ion concentration	biological process	Any process that increases the concentration of calcium ions in the cytosol. [GOC:ai]
learning or memory	biological process	The acquisition and processing of information and/or the storage and retrieval of this information over time. [GOC:jid, PMID:8938125]
regulation of heart contraction	biological process	Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body. [GOC:dph, GOC:go_curators, GOC:tb]
cAMP-mediated signaling	biological process	An intracellular signaling cassette that starts with production of cyclic AMP (cAMP), and ends with activation of downstream effectors that further transmit the signal within the cell. [GOC:signaling]
post-translational protein targeting to membrane, translocation	biological process	The process in which a protein translocates through the ER membrane posttranslationally. [PMID:12518317, PMID:8707814]
negative regulation of blood pressure	biological process	Any process in which the force of blood traveling through the circulatory system is decreased. [GOC:go_curators, GOC:mtg_cardio]
hormone secretion	biological process	The regulated release of hormones, substances with a specific regulatory effect on a particular organ or group of cells. [ISBN:0198506732]
cellular response to glucagon stimulus	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus. [GOC:mah]
response to psychosocial stress	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of exposure to aversive or demanding psychological and social conditions that tax or exceed the behavioral resources of the organism. [PMID:22922217, PMID:26458179]
positive regulation of blood pressure	biological process	Any process in which the force of blood traveling through the circulatory system is increased. [GOC:go_curators, GOC:mtg_cardio]

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