Compounds > isocoumarins
Page last updated: 2024-09-23

isocoumarins

Description

Isocoumarins: Compounds that differ from COUMARINS in having the positions of the ring and ketone oxygens reversed so the keto oxygen is at the 1-position of the molecule. [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

isocoumarin : The simplest member of the class of isocoumarins that is 1H-isochromene which is substituted by an oxo group at position 1. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID68108
CHEMBL ID457811
CHEBI ID38759
SCHEMBL ID76183
MeSH IDM0471145

Synonyms (23)

Synonym
1h-2-benzopyran-1-one
isocoumarin
isochromen-1-one
CHEMBL457811
chebi:38759 ,
491-31-6
AKOS006285714
benzoic acid, 2-(2-hydroxyethenyl)-, delta-lactone
sr89982s3e ,
unii-sr89982s3e
isocoumarins
3,4-benzo-2-pyrone
1h-isochromen-1-one
FT-0607868
SCHEMBL76183
DTXSID8060080
IQZZFVDIZRWADY-UHFFFAOYSA-N
N10038
Q412756
mfcd08061387
AS-76786
EN300-6487432
Z1198175817

Effects

ExcerptReference
"Four isocoumarins have been isolated from the terrestrial Streptomyces sp. "( Abdalla, MA; Islam, MT; Laatsch, H; Schüffler, A; Shaaban, KA; Zinad, DS, 2011)

Drug Classes (1)

ClassDescription
isocoumarins
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (2)

Assay IDTitleYearJournalArticle
AID399186Antifungal activity against Cladosporium herbarum assessed as inhibition zone in mycelial layer assessed per spot by TLC bioautography assay2004Journal of natural products, Jan, Volume: 67, Issue:1
Antifungal 3-butylisocoumarins from Asteraceae-Anthemideae.
AID399185Antifungal activity against Pyricularia grisea assessed as inhibition of germ-tube development by microdilution method2004Journal of natural products, Jan, Volume: 67, Issue:1
Antifungal 3-butylisocoumarins from Asteraceae-Anthemideae.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (545)

TimeframeStudies, This Drug (%)All Drugs %
pre-199019 (3.49)18.7374
1990's94 (17.25)18.2507
2000's110 (20.18)29.6817
2010's247 (45.32)24.3611
2020's75 (13.76)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (0.18%)5.53%
Reviews20 (3.60%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other534 (96.22%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
benomyl[no description available]medium10aromatic amide;
benzimidazole fungicide;
benzimidazoles;
benzimidazolylcarbamate fungicide;
carbamate ester		acaricide;
anthelminthic drug;
antifungal agrochemical;
microtubule-destabilising agent;
tubulin modulator
griseofulvin[no description available]medium101-benzofurans;
antibiotic antifungal drug;
benzofuran antifungal drug;
organochlorine compound;
oxaspiro compound		antibacterial agent;
Penicillium metabolite
Capillarin[no description available]medium10isocoumarins
kresoxim-methyl[no description available]medium10aromatic ether;
methoxyiminoacetate strobilurin antifungal agent;
methyl ester;
oxime O-ether		antifungal agrochemical;
environmental contaminant;
mitochondrial cytochrome-bc1 complex inhibitor;
xenobiotic
agrimonolide[no description available]medium80
cyclopropane[no description available]medium20cycloalkane;
cyclopropanes		inhalation anaesthetic
palladium[no description available]medium120metal allergen;
nickel group element atom;
platinum group metal atom
stilbenes[no description available]medium50stilbene
glycosides[no description available]medium180
iodine[no description available]medium30diatomic iodinenutrient
iodine[no description available]medium20halide anion;
monoatomic iodine		human metabolite
phenyl acetate[no description available]medium40benzenes;
phenyl acetates
phthalide[no description available]medium602-benzofurans;
gamma-lactone
indomethacin[no description available]medium20aromatic ether;
indole-3-acetic acids;
monochlorobenzenes;
N-acylindole		analgesic;
drug metabolite;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
gout suppressant;
non-steroidal anti-inflammatory drug;
xenobiotic metabolite;
xenobiotic
gold[no description available]medium20copper group element atom;
elemental gold
pyrazines[no description available]medium10diazine;
pyrazines		Daphnia magna metabolite
9,10-anthraquinone[no description available]medium20anthraquinone
noscapine[no description available]medium10aromatic ether;
benzylisoquinoline alkaloid;
cyclic acetal;
isobenzofuranone;
organic heterobicyclic compound;
organic heterotricyclic compound;
tertiary amino compound		antineoplastic agent;
antitussive;
apoptosis inducer;
plant metabolite
carbonates[no description available]medium20carbon oxoanion
cladosporin[no description available]medium250
warfarin[no description available]medium1831benzenes;
hydroxycoumarin;
methyl ketone
shikimic acid[no description available]medium10alpha,beta-unsaturated monocarboxylic acid;
cyclohexenecarboxylic acid;
hydroxy monocarboxylic acid		Escherichia coli metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite
galloflavin[no description available]medium180
pinophilin b[no description available]medium20
hydrangenol[no description available]medium170dihydroisocoumarins;
phenols		anti-allergic agent;
plant metabolite
lactic acid[no description available]medium402-hydroxy monocarboxylic acidalgal metabolite;
Daphnia magna metabolite
metformin[no description available]medium10guanidinesenvironmental contaminant;
geroprotector;
hypoglycemic agent;
xenobiotic
sesquiterpenes[no description available]medium50
ochracin[no description available]medium140isochromanes
4-hydroxymellein[no description available]medium40
3,4-dichloroisocoumarin[no description available]medium770isocoumarins;
organochlorine compound		geroprotector;
serine protease inhibitor
galactose[no description available]medium10D-galactose;
galactopyranose		Escherichia coli metabolite;
mouse metabolite
acetylgalactosamine[no description available]medium10N-acetyl-D-hexosamine;
N-acetylgalactosamine		Escherichia coli metabolite;
human metabolite;
mouse metabolite
triazoles[no description available]medium201,2,3-triazole
methanol[no description available]medium60alkyl alcohol;
one-carbon compound;
primary alcohol;
volatile organic compound		amphiprotic solvent;
Escherichia coli metabolite;
fuel;
human metabolite;
mouse metabolite;
Mycoplasma genitalium metabolite
quercetin[no description available]medium407-hydroxyflavonol;
pentahydroxyflavone		antibacterial agent;
antineoplastic agent;
antioxidant;
Aurora kinase inhibitor;
chelator;
EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor;
geroprotector;
phytoestrogen;
plant metabolite;
protein kinase inhibitor;
radical scavenger
iridium[no description available]medium10cobalt group element atom;
platinum group metal atom
fluorine[no description available]medium10diatomic fluorine;
gas molecular entity		NMR chemical shift reference compound
benzofurans[no description available]medium230
ellagic acid[no description available]medium20catechols;
cyclic ketone;
lactone;
organic heterotetracyclic compound;
polyphenol		antioxidant;
EC 1.14.18.1 (tyrosinase) inhibitor;
EC 2.3.1.5 (arylamine N-acetyltransferase) inhibitor;
EC 2.4.1.1 (glycogen phosphorylase) inhibitor;
EC 2.5.1.18 (glutathione transferase) inhibitor;
EC 2.7.1.127 (inositol-trisphosphate 3-kinase) inhibitor;
EC 2.7.1.151 (inositol-polyphosphate multikinase) inhibitor;
EC 2.7.4.6 (nucleoside-diphosphate kinase) inhibitor;
EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
food additive;
fungal metabolite;
geroprotector;
plant metabolite;
skin lightening agent
6-hydroxymellein[no description available]medium90isochromanes
palladium chloride[no description available]medium20palladium coordination entitycatalyst
dicyanmethane[no description available]medium10aliphatic nitrile;
dinitrile
indium[no description available]medium10boron group element atom
pyrazole[no description available]medium10pyrazole
ferulic acid[no description available]medium20ferulic acidsanti-inflammatory agent;
antioxidant;
apoptosis inhibitor;
cardioprotective agent;
MALDI matrix material;
plant metabolite
quinic acid[no description available]medium10
chlorogenic acid[no description available]medium20cinnamate ester;
tannin		food component;
plant metabolite
oxamic acid[no description available]medium40dicarboxylic acid monoamideEscherichia coli metabolite
benzil[no description available]medium10alpha-diketone;
aromatic ketone
phenylglyoxal[no description available]medium10phenylacetaldehydes
phenanthrenes[no description available]medium10
austin[no description available]medium10
eudesmane[no description available]medium10sesquiterpene;
terpenoid fundamental parent
6-methoxy-8-hydroxy-3-methyl-3,4-dihydroisocoumarin[no description available]medium80isochromanes
phenol[no description available]medium10phenolsantiseptic drug;
disinfectant;
human xenobiotic metabolite;
mouse metabolite
naphthoquinones[no description available]medium70
diaporthin[no description available]medium20
thiourea[no description available]medium20one-carbon compound;
thioureas;
ureas		antioxidant;
chromophore
1,1-diphenyl-2-picrylhydrazyl[no description available]medium70
paepalantine[no description available]medium60
rhodium[no description available]medium40cobalt group element atom
cyclopentenone[no description available]medium10alicyclic ketone;
enone		Hsp70 inducer
cyclopentane[no description available]medium30cycloalkane;
cyclopentanes;
volatile organic compound		non-polar solvent
falcarindiol[no description available]medium20organic molecular entitymetabolite
benzylidenephthalide[no description available]medium10
malvidin[no description available]medium105-hydroxyanthocyanidinbiological pigment;
metabolite
nad[no description available]medium10organophosphate oxoanioncofactor;
human metabolite;
hydrogen acceptor;
Saccharomyces cerevisiae metabolite
tetramic acid[no description available]medium10
emerimicins[no description available]medium10
glucose, (beta-d)-isomer[no description available]medium110D-glucopyranoseepitope;
mouse metabolite
methylaniline[no description available]medium10methylaniline;
phenylalkylamine;
secondary amine
acetic acid[no description available]medium10monocarboxylic acidantimicrobial food preservative;
Daphnia magna metabolite;
food acidity regulator;
protic solvent
aniline[no description available]medium10anilines;
primary arylamine
benzoic acid[no description available]medium20benzoic acidsalgal metabolite;
antimicrobial food preservative;
drug allergen;
EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor;
EC 3.1.1.3 (triacylglycerol lipase) inhibitor;
human xenobiotic metabolite;
plant metabolite
levofloxacin[no description available]medium209-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid;
fluoroquinolone antibiotic;
quinolone antibiotic		antibacterial drug;
DNA synthesis inhibitor;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
topoisomerase IV inhibitor
5-chloro-8-hydroxy-3,4-dihydro-3-methylisocoumarin-7-carboxylic acid[no description available]medium30
ochratoxin a[no description available]medium40isochromanes;
monocarboxylic acid amide;
N-acyl-L-phenylalanine;
organochlorine compound;
phenylalanine derivative		Aspergillus metabolite;
calcium channel blocker;
carcinogenic agent;
mycotoxin;
nephrotoxin;
Penicillium metabolite;
teratogenic agent
icd 1578[no description available]medium30
norbergenin[no description available]medium10
propargyl alcohol[no description available]medium10propynol;
terminal acetylenic compound;
volatile organic compound		antifungal agent;
Saccharomyces cerevisiae metabolite
erythrocentaurin[no description available]medium90
swertiamarin[no description available]medium30glycoside
carbon tetrachloride[no description available]medium10chlorocarbon;
chloromethanes		hepatotoxic agent;
refrigerant
gamma-rubromycin[no description available]medium20
trifluoromethanesulfonic acid[no description available]medium10one-carbon compound;
perfluoroalkanesulfonic acid
fluoroboric acid[no description available]medium10boron fluoride
dihydrochalcone[no description available]medium20dihydrochalconesplant metabolite
isovanillin[no description available]medium20benzaldehydes;
monomethoxybenzene;
phenols		animal metabolite;
antidiarrhoeal drug;
antifungal agent;
EC 1.2.3.1 (aldehyde oxidase) inhibitor;
HIV protease inhibitor;
plant metabolite
phyllodulcin, (r)-isomer[no description available]medium130hydroxybenzoic acid
chalcone[no description available]medium30chalconeEC 3.2.1.1 (alpha-amylase) inhibitor
hyperoside[no description available]medium10beta-D-galactoside;
monosaccharide derivative;
quercetin O-glycoside;
tetrahydroxyflavone		hepatoprotective agent;
plant metabolite
rutin[no description available]medium10disaccharide derivative;
quercetin O-glucoside;
rutinoside;
tetrahydroxyflavone		antioxidant;
metabolite
organophosphonates[no description available]medium20divalent inorganic anion;
phosphite ion
monocerin[no description available]medium20hydroxybenzoic acidmetabolite
cyanides[no description available]medium20pseudohalide anionEC 1.9.3.1 (cytochrome c oxidase) inhibitor
carbene[no description available]medium10carbene;
methanediyl
methane[no description available]medium10alkane;
gas molecular entity;
mononuclear parent hydride;
one-carbon compound		bacterial metabolite;
fossil fuel;
greenhouse gas
pyrimidinones[no description available]medium30
3-hydroxybutanal[no description available]medium20
altenuene[no description available]medium10
vinyl acetate[no description available]medium10acetate ester
2,4-dinitrophenylhydrazine[no description available]medium20C-nitro compound;
phenylhydrazines		reagent
gentiopicroside[no description available]medium10glycoside
iridoids[no description available]medium40
mannose[no description available]medium10D-aldohexose;
D-mannose;
mannopyranose		metabolite
ruthenium[no description available]medium60iron group element atom;
platinum group metal atom
alkenes[no description available]medium20
alanine[no description available]medium20alanine zwitterion;
alanine;
L-alpha-amino acid;
proteinogenic amino acid;
pyruvate family amino acid		EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitor;
fundamental metabolite
pyruvic acid[no description available]medium102-oxo monocarboxylic acidcofactor;
fundamental metabolite
dinoprostone[no description available]medium30prostaglandins Ehuman metabolite;
mouse metabolite;
oxytocic
fluorouracil[no description available]medium20nucleobase analogue;
organofluorine compound		antimetabolite;
antineoplastic agent;
environmental contaminant;
immunosuppressive agent;
radiosensitizing agent;
xenobiotic
isosalipurposide[no description available]medium10beta-D-glucoside;
chalcones;
monosaccharide derivative;
resorcinols		antioxidant;
plant metabolite
bergenin[no description available]medium10trihydroxybenzoic acidmetabolite
quercitrin[no description available]medium10alpha-L-rhamnoside;
monosaccharide derivative;
quercetin O-glycoside;
tetrahydroxyflavone		antileishmanial agent;
antioxidant;
EC 1.1.1.184 [carbonyl reductase (NADPH)] inhibitor;
EC 1.1.1.21 (aldehyde reductase) inhibitor;
EC 1.14.18.1 (tyrosinase) inhibitor;
plant metabolite
7-amino-3-(2-bromoethoxy)-4-chloroisocoumarin[no description available]medium31
erythromycin[no description available]medium10cyclic ketone;
erythromycin
protocatechuic acid[no description available]medium10catechols;
dihydroxybenzoic acid		antineoplastic agent;
EC 1.1.1.25 (shikimate dehydrogenase) inhibitor;
EC 1.14.11.2 (procollagen-proline dioxygenase) inhibitor;
human xenobiotic metabolite;
plant metabolite
mevalonic acid[no description available]medium103,5-dihydroxy-3-methylpentanoic acid
deoxyglucose[no description available]medium10
curcumin[no description available]medium10aromatic ether;
beta-diketone;
diarylheptanoid;
enone;
polyphenol		anti-inflammatory agent;
antifungal agent;
antineoplastic agent;
biological pigment;
contraceptive drug;
dye;
EC 1.1.1.205 (IMP dehydrogenase) inhibitor;
EC 1.1.1.21 (aldehyde reductase) inhibitor;
EC 1.1.1.25 (shikimate dehydrogenase) inhibitor;
EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor;
EC 1.8.1.9 (thioredoxin reductase) inhibitor;
EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor;
EC 3.5.1.98 (histone deacetylase) inhibitor;
flavouring agent;
food colouring;
geroprotector;
hepatoprotective agent;
immunomodulator;
iron chelator;
ligand;
lipoxygenase inhibitor;
metabolite;
neuroprotective agent;
nutraceutical;
radical scavenger
chlorhexidine[no description available]medium11biguanides;
monochlorobenzenes		antibacterial agent;
antiinfective agent
catechin[no description available]medium10catechinantioxidant;
plant metabolite
procyanidin[no description available]medium10proanthocyanidin
phloroglucinol[no description available]medium10benzenetriol;
phenolic donor		algal metabolite
arachidonic acid[no description available]medium10icosa-5,8,11,14-tetraenoic acid;
long-chain fatty acid;
omega-6 fatty acid		Daphnia galeata metabolite;
EC 3.1.1.1 (carboxylesterase) inhibitor;
human metabolite;
mouse metabolite
1,3-butadiene[no description available]medium10butadienecarcinogenic agent;
mutagen
coumarin[no description available]medium30coumarinsfluorescent dye;
human metabolite;
plant metabolite
toluene[no description available]medium10methylbenzene;
toluenes;
volatile organic compound		cholinergic antagonist;
fuel additive;
neurotoxin;
non-polar solvent
ascorbic acid[no description available]medium10ascorbic acid;
vitamin C		coenzyme;
cofactor;
flour treatment agent;
food antioxidant;
food colour retention agent;
geroprotector;
plant metabolite;
skin lightening agent
citrinin[no description available]medium20
jasmonic acid[no description available]medium10oxo monocarboxylic acidjasmonates;
plant metabolite
4-hydroxyphenylethanol[no description available]medium10phenolsanti-arrhythmia drug;
antioxidant;
cardiovascular drug;
fungal metabolite;
geroprotector;
plant metabolite;
protective agent
4-hydroxybenzoic acid[no description available]medium10monohydroxybenzoic acidalgal metabolite;
plant metabolite
phenylethyl alcohol[no description available]medium20benzenes;
primary alcohol		Aspergillus metabolite;
fragrance;
plant growth retardant;
plant metabolite;
Saccharomyces cerevisiae metabolite
propylparaben[no description available]medium10benzoate ester;
paraben;
phenols		antifungal agent;
antimicrobial agent
carbon monoxide[no description available]medium20carbon oxide;
gas molecular entity;
one-carbon compound		biomarker;
EC 1.9.3.1 (cytochrome c oxidase) inhibitor;
human metabolite;
ligand;
metabolite;
mitochondrial respiratory-chain inhibitor;
mouse metabolite;
neurotoxin;
neurotransmitter;
P450 inhibitor;
probe;
signalling molecule;
vasodilator agent
gossypol[no description available]medium10
dinitrobenzenes[no description available]medium10
ergosta-4,6,8(14),22-tetraen-3-one[no description available]medium103-oxo-Delta(4) steroid;
ergostanoid		fungal metabolite
homophthalic acid[no description available]medium10
1-hexanol[no description available]medium20hexanol;
primary alcohol		alarm pheromone;
antibacterial agent;
fragrance;
plant metabolite
eutypine[no description available]medium10
luteolin[no description available]medium203'-hydroxyflavonoid;
tetrahydroxyflavone		angiogenesis inhibitor;
anti-inflammatory agent;
antineoplastic agent;
apoptosis inducer;
c-Jun N-terminal kinase inhibitor;
EC 2.3.1.85 (fatty acid synthase) inhibitor;
immunomodulator;
nephroprotective agent;
plant metabolite;
radical scavenger;
vascular endothelial growth factor receptor antagonist
apigenin[no description available]medium10trihydroxyflavoneantineoplastic agent;
metabolite
sucrose[no description available]medium10glycosyl glycosidealgal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
osmolyte;
Saccharomyces cerevisiae metabolite;
sweetening agent
lyoniside[no description available]medium10
thunberginol a[no description available]medium140
gamma-sitosterol[no description available]medium203beta-hydroxy-Delta(5)-steroid;
3beta-sterol;
phytosterols		marine metabolite;
plant metabolite
cytellin[no description available]medium20
bafilomycin a1[no description available]medium10cyclic hemiketal;
macrolide antibiotic;
oxanes		apoptosis inducer;
autophagy inhibitor;
bacterial metabolite;
EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor;
EC 3.6.3.14 (H(+)-transporting two-sector ATPase) inhibitor;
ferroptosis inhibitor;
fungicide;
potassium ionophore;
toxin
4-(2-aminoethyl)benzenesulfonylfluoride[no description available]medium60
1,2,4-trimethoxybenzene[no description available]medium10methoxybenzenes
naphthazarin[no description available]medium10hydroxy-1,4-naphthoquinoneacaricide;
antibacterial agent;
antineoplastic agent;
apoptosis inducer;
geroprotector;
plant metabolite
neoechinulin[no description available]medium20
mycophenolic acid[no description available]medium102-benzofurans;
gamma-lactone;
monocarboxylic acid;
phenols		anticoronaviral agent;
antimicrobial agent;
antineoplastic agent;
EC 1.1.1.205 (IMP dehydrogenase) inhibitor;
environmental contaminant;
immunosuppressive agent;
mycotoxin;
Penicillium metabolite;
xenobiotic
sterigmatocystin[no description available]medium20sterigmatocystinsmetabolite
2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid[no description available]medium10
caffeic acid[no description available]medium10caffeic acidgeroprotector;
mouse metabolite
lignans[no description available]medium10
conidendrin[no description available]medium10lignanmetabolite
1,10-phenanthroline[no description available]medium20phenanthrolineEC 2.7.1.1 (hexokinase) inhibitor;
EC 3.4.19.3 (pyroglutamyl-peptidase I) inhibitor
nelfinavir[no description available]medium10aryl sulfide;
benzamides;
organic heterobicyclic compound;
phenols;
secondary alcohol;
tertiary amino compound		antineoplastic agent;
HIV protease inhibitor
1,7-phenanthroline[no description available]medium20phenanthroline
curdlan[no description available]medium10hexose
brevianamide a[no description available]medium10
epiglucan[no description available]medium10
neoechinulin a[no description available]medium10
hopane[no description available]medium10terpenoid fundamental parent;
triterpene
gamma-resorcylic acid[no description available]medium10dihydroxybenzoic acidmetabolite
naphthalene[no description available]medium10naphthalenes;
ortho-fused bicyclic arene		apoptosis inhibitor;
carcinogenic agent;
environmental contaminant;
mouse metabolite;
plant metabolite;
volatile oil component
1-anilino-8-naphthalenesulfonate[no description available]medium20aminonaphthalene;
naphthalenesulfonic acid		fluorescent probe
isoflurophate[no description available]medium60dialkyl phosphate
cyclopropene[no description available]medium10cycloalkene;
cyclopropenes
sch 725680[no description available]medium10
1,7-diaminoheptane[no description available]medium10
zinc oxide[no description available]medium10zinc molecular entity
oxazoles[no description available]medium201,3-oxazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
concanamycin a[no description available]medium20carbamate ester;
concanamycin		antifungal agent;
EC 3.6.3.14 (H(+)-transporting two-sector ATPase) inhibitor;
metabolite
inosine[no description available]medium10inosines;
purines D-ribonucleoside		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
cupric chloride[no description available]medium10copper molecular entity;
inorganic chloride		EC 5.3.3.5 (cholestenol Delta-isomerase) inhibitor
arabinose[no description available]medium10L-arabinoseEscherichia coli metabolite;
mouse metabolite
penicillic acid[no description available]medium10
tert-butyl isocyanide[no description available]medium10
pyrrolidine[no description available]medium10azacycloalkane;
pyrrolidines;
saturated organic heteromonocyclic parent
ofloxacin[no description available]medium103-oxo monocarboxylic acid;
N-arylpiperazine;
N-methylpiperazine;
organofluorine compound;
oxazinoquinoline
aspterric acid[no description available]medium10
e 64[no description available]medium20dicarboxylic acid monoamide;
epoxy monocarboxylic acid;
guanidines;
L-leucine derivative;
zwitterion		antimalarial;
antiparasitic agent;
protease inhibitor
pepstatin[no description available]medium40pentapeptide;
secondary carboxamide		bacterial metabolite;
EC 3.4.23.* (aspartic endopeptidase) inhibitor
leucine[no description available]medium30amino acid zwitterion;
L-alpha-amino acid;
leucine;
proteinogenic amino acid;
pyruvate family amino acid		algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite
isocoumarin nm-3[no description available]medium160
lunularic acid[no description available]medium10stilbenoid
coenzyme a[no description available]medium10adenosine 3',5'-bisphosphatecoenzyme;
Escherichia coli metabolite;
mouse metabolite
salicylates[no description available]medium10monohydroxybenzoateplant metabolite
cytogenin[no description available]medium130
panaxynol[no description available]medium10long-chain fatty alcohol
gallic acid[no description available]medium10trihydroxybenzoic acidantineoplastic agent;
antioxidant;
apoptosis inducer;
astringent;
cyclooxygenase 2 inhibitor;
EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor;
geroprotector;
human xenobiotic metabolite;
plant metabolite
eugeniin[no description available]medium10beta-D-glucoside;
ellagitannin;
gallate ester;
lactone		anti-HSV-1 agent;
antifungal agent;
antineoplastic agent;
EC 3.2.1.20 (alpha-glucosidase) inhibitor;
metabolite
luminol[no description available]medium10
hypochlorous acid[no description available]medium10chlorine oxoacid;
reactive oxygen species		EC 2.5.1.18 (glutathione transferase) inhibitor;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
human metabolite
mocetinostat[no description available]medium10aminopyrimidine;
benzamides;
pyridines;
secondary amino compound;
secondary carboxamide;
substituted aniline		antineoplastic agent;
apoptosis inducer;
autophagy inducer;
cardioprotective agent;
EC 3.5.1.98 (histone deacetylase) inhibitor;
hepatotoxic agent
acridines[no description available]medium10acridines;
mancude organic heterotricyclic parent;
polycyclic heteroarene		genotoxin
10,10'-dimethyl-9,9'-biacridinium[no description available]medium10
7-amino-4-chloro-3-(3-isothiureidopropoxy)isocoumarin[no description available]medium30
carboplatin[no description available]medium20
fumonisin b1[no description available]medium10diester;
fumonisin;
primary amino compound;
triol		carcinogenic agent;
metabolite
sq-23377[no description available]medium10cyclic ether;
enol;
polyunsaturated fatty acid;
very long-chain fatty acid		calcium ionophore;
metabolite
glycolipids[no description available]medium20
methylene chloride[no description available]medium10chloromethanes;
volatile organic compound		carcinogenic agent;
polar aprotic solvent;
refrigerant
tetracycline[no description available]medium10
kanamycin a[no description available]medium10kanamycinsbacterial metabolite
phthalylsulfathiazole[no description available]medium101,3-thiazoles;
dicarboxylic acid monoamide;
sulfonamide antibiotic;
sulfonamide
cytochrome c-t[no description available]medium20
docetaxel anhydrous[no description available]medium10secondary alpha-hydroxy ketone;
tetracyclic diterpenoid		antimalarial;
antineoplastic agent;
photosensitizing agent
phytoestrogens[no description available]medium10
transforming growth factor beta[no description available]medium10
propadiene[no description available]medium20allenes
orsellinic acid[no description available]medium10dihydroxybenzoic acid;
resorcinols		fungal metabolite;
marine metabolite;
metabolite
cruentaren a[no description available]medium10macrolide
lovastatin[no description available]medium10delta-lactone;
fatty acid ester;
hexahydronaphthalenes;
polyketide;
statin (naturally occurring)		anticholesteremic drug;
antineoplastic agent;
Aspergillus metabolite;
prodrug
thunberginol f[no description available]medium50catechols;
gamma-lactone;
isobenzofuranone		metabolite;
plant metabolite
thunberginol b[no description available]medium60
calcimycin[no description available]medium30benzoxazole
psymberin[no description available]medium10hydroxybenzoic acid
2-naphthol[no description available]medium10naphtholantinematodal drug;
genotoxin;
human urinary metabolite;
human xenobiotic metabolite;
mouse metabolite;
radical scavenger
tyramine[no description available]medium10monoamine molecular messenger;
primary amino compound;
tyramines		EC 3.1.1.8 (cholinesterase) inhibitor;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
neurotransmitter
feruloyltyramine[no description available]medium10tyraminesmetabolite
oxymatrine[no description available]medium10
hydroxyl radical[no description available]medium10oxygen hydride;
oxygen radical;
reactive oxygen species
hydrazine[no description available]medium10azane;
hydrazines		EC 4.3.1.10 (serine-sulfate ammonia-lyase) inhibitor
vitamin b 12[no description available]medium10
paclitaxel[no description available]medium30taxane diterpenoid;
tetracyclic diterpenoid		antineoplastic agent;
human metabolite;
metabolite;
microtubule-stabilising agent
physcione[no description available]medium10dihydroxyanthraquinoneanti-inflammatory agent;
antibacterial agent;
antifungal agent;
antineoplastic agent;
apoptosis inducer;
hepatoprotective agent;
metabolite
emodin[no description available]medium20trihydroxyanthraquinoneantineoplastic agent;
laxative;
plant metabolite;
tyrosine kinase inhibitor
quinone[no description available]medium101,4-benzoquinonescofactor;
human xenobiotic metabolite;
mouse metabolite
ventiloquinone l[no description available]medium10
butyrolactone i[no description available]medium10butenolide
4-butyrolactone[no description available]medium10butan-4-olidemetabolite;
neurotoxin
terrein[no description available]medium10polyol
2-ethylhexanal[no description available]medium10saturated fatty aldehydebacterial xenobiotic metabolite;
fungal metabolite
moxidectin[no description available]medium10
ai 77b[no description available]medium40
flavone[no description available]medium10flavonesmetabolite;
nematicide
alpha-chymotrypsin[no description available]medium40
edetic acid[no description available]medium30ethylenediamine derivative;
polyamino carboxylic acid;
tetracarboxylic acid		anticoagulant;
antidote;
chelator;
copper chelator;
geroprotector
tosylphenylalanyl chloromethyl ketone[no description available]medium40alpha-chloroketone;
sulfonamide		alkylating agent;
serine proteinase inhibitor
sulfaguanidine[no description available]medium10sulfonamide antibioticantiinfective agent
medroxyprogesterone[no description available]medium1017alpha-hydroxy steroid;
20-oxo steroid;
3-oxo-Delta(4) steroid;
tertiary alpha-hydroxy ketone		contraceptive drug;
progestin;
synthetic oral contraceptive
sodium dodecyl sulfate[no description available]medium50organic sodium saltdetergent;
protein denaturant
2-benzimidazolylguanidine[no description available]medium10aminoimidazole
pentamidine[no description available]medium10aromatic ether;
carboxamidine;
diether		anti-inflammatory agent;
antifungal agent;
calmodulin antagonist;
chemokine receptor 5 antagonist;
EC 2.3.1.48 (histone acetyltransferase) inhibitor;
NMDA receptor antagonist;
S100 calcium-binding protein B inhibitor;
trypanocidal drug;
xenobiotic
4'-acetamidophenyl 4-guanidinobenzoate[no description available]medium10
conagenin[no description available]medium10
delaminomycin a[no description available]medium10
serine[no description available]medium20L-alpha-amino acid;
proteinogenic amino acid;
serine family amino acid;
serine zwitterion;
serine		algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
tetradecanoylphorbol acetate[no description available]medium30acetate ester;
diester;
phorbol ester;
tertiary alpha-hydroxy ketone;
tetradecanoate ester		antineoplastic agent;
apoptosis inducer;
carcinogenic agent;
mitogen;
plant metabolite;
protein kinase C agonist;
reactive oxygen species generator
aurintricarboxylic acid[no description available]medium20monohydroxybenzoic acid;
quinomethanes;
tricarboxylic acid		fluorochrome;
histological dye;
insulin-like growth factor receptor 1 antagonist
tyrosine[no description available]medium20amino acid zwitterion;
erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid;
proteinogenic amino acid;
tyrosine		EC 1.3.1.43 (arogenate dehydrogenase) inhibitor;
fundamental metabolite;
micronutrient;
nutraceutical
arginine[no description available]medium10arginine;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid		biomarker;
Escherichia coli metabolite;
micronutrient;
mouse metabolite;
nutraceutical
ethyl n-alpha-acetyl-tyrosinate[no description available]medium10acetamides;
ethyl ester;
L-tyrosine derivative;
phenols
benzoylarginine ethyl ester[no description available]medium10
concanavalin a[no description available]medium10
mercaptoethanol[no description available]medium10alkanethiol;
primary alcohol		geroprotector
phenylalanine[no description available]medium20amino acid zwitterion;
erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid;
phenylalanine;
proteinogenic amino acid		algal metabolite;
EC 3.1.3.1 (alkaline phosphatase) inhibitor;
Escherichia coli metabolite;
human xenobiotic metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
gi 129471[no description available]medium10
egtazic acid[no description available]medium20diether;
tertiary amino compound;
tetracarboxylic acid		chelator
methionine[no description available]medium10aspartate family amino acid;
L-alpha-amino acid;
methionine zwitterion;
methionine;
proteinogenic amino acid		antidote to paracetamol poisoning;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical
bucladesine[no description available]medium103',5'-cyclic purine nucleotide
colforsin[no description available]medium10acetate ester;
cyclic ketone;
labdane diterpenoid;
organic heterotricyclic compound;
tertiary alpha-hydroxy ketone;
triol		adenylate cyclase agonist;
anti-HIV agent;
antihypertensive agent;
plant metabolite;
platelet aggregation inhibitor;
protein kinase A agonist
lauric acid[no description available]medium10medium-chain fatty acid;
straight-chain saturated fatty acid		algal metabolite;
antibacterial agent;
plant metabolite
4-(2-aminoethyl)benzenesulfonamide[no description available]medium10
chromonar[no description available]medium10coumarins
chrysin[no description available]medium107-hydroxyflavonol;
dihydroxyflavone		anti-inflammatory agent;
antineoplastic agent;
antioxidant;
EC 2.7.11.18 (myosin-light-chain kinase) inhibitor;
hepatoprotective agent;
plant metabolite
n-acetylserotonin[no description available]medium10acetamides;
N-acylserotonin;
phenols		antioxidant;
human metabolite;
mouse metabolite;
tropomyosin-related kinase B receptor agonist
p-chloromercuribenzoic acid[no description available]medium20chlorine molecular entity;
mercuribenzoic acid
fenton's reagent[no description available]medium10
2-bromohydroquinone[no description available]medium10
antipain[no description available]medium20
tert-butylhydroperoxide[no description available]medium10alkyl hydroperoxideantibacterial agent;
oxidising agent
cysteine[no description available]medium10cysteiniumfundamental metabolite
leupeptin[no description available]medium20aldehyde;
tripeptide		bacterial metabolite;
calpain inhibitor;
cathepsin B inhibitor;
EC 3.4.21.4 (trypsin) inhibitor;
serine protease inhibitor
antimycin a[no description available]medium10amidobenzoic acid
leupeptins[no description available]medium40
tosyllysine chloromethyl ketone[no description available]medium20sulfonic acid derivative
s-(1,1,2,2-tetrafluoroethyl)cysteine[no description available]medium10
pristane[no description available]medium10long-chain alkane;
norterpene		biomarker;
immunological adjuvant
n-benzyloxycarbonyl-leucyl-valyl-glycine diazomethane[no description available]medium10
acetylleucyl-leucyl-norleucinal[no description available]medium10aldehyde;
tripeptide		cysteine protease inhibitor
cycloheximide[no description available]medium20antibiotic fungicide;
cyclic ketone;
dicarboximide;
piperidine antibiotic;
piperidones;
secondary alcohol		anticoronaviral agent;
bacterial metabolite;
ferroptosis inhibitor;
neuroprotective agent;
protein synthesis inhibitor
diazomethane[no description available]medium20diazo compoundalkylating agent;
antineoplastic agent;
carcinogenic agent;
poison
calpain[no description available]medium10
4-toluenesulfonyl fluoride[no description available]medium10
succinyl-trialanine-4-nitroanilide[no description available]medium10
tranilast[no description available]medium10amidobenzoic acid;
cinnamamides;
dimethoxybenzene;
secondary carboxamide		anti-allergic agent;
anti-asthmatic drug;
antineoplastic agent;
aryl hydrocarbon receptor agonist;
calcium channel blocker;
hepatoprotective agent;
nephroprotective agent
lactacystin[no description available]medium50lactam;
S-substituted L-cysteine
acetylcysteine[no description available]medium50acetylcysteine;
L-cysteine derivative;
N-acetyl-L-amino acid		antidote to paracetamol poisoning;
antiinfective agent;
antioxidant;
antiviral drug;
ferroptosis inhibitor;
geroprotector;
human metabolite;
mucolytic;
radical scavenger;
vulnerary
daunorubicin[no description available]medium20aminoglycoside antibiotic;
anthracycline;
p-quinones;
tetracenequinones		antineoplastic agent;
bacterial metabolite
camptothecin[no description available]medium20delta-lactone;
pyranoindolizinoquinoline;
quinoline alkaloid;
tertiary alcohol		antineoplastic agent;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
genotoxin;
plant metabolite
benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone[no description available]medium10
ng-nitroarginine methyl ester[no description available]medium20alpha-amino acid ester;
L-arginine derivative;
methyl ester;
N-nitro compound		EC 1.14.13.39 (nitric oxide synthase) inhibitor
bradykinin[no description available]medium30oligopeptidehuman blood serum metabolite;
vasodilator agent
phosphoramidon[no description available]medium10deoxyaldohexose phosphate;
dipeptide		bacterial metabolite;
EC 3.4.24.11 (neprilysin) inhibitor;
EC 3.4.24.71 (endothelin-converting enzyme 1) inhibitor
thiorphan[no description available]medium10N-acyl-amino acid
ramipril[no description available]medium20azabicycloalkane;
cyclopentapyrrole;
dicarboxylic acid monoester;
dipeptide;
ethyl ester		bradykinin receptor B2 agonist;
cardioprotective agent;
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor;
matrix metalloproteinase inhibitor;
prodrug
icatibant[no description available]medium30
ramiprilat[no description available]medium20azabicycloalkane;
cyclopentapyrrole;
dicarboxylic acid;
dipeptide		bradykinin receptor B2 agonist;
cardioprotective agent;
drug metabolite;
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor;
matrix metalloproteinase inhibitor
nitrates[no description available]medium10monovalent inorganic anion;
nitrogen oxoanion;
reactive nitrogen species
azomethane[no description available]medium10
juglone[no description available]medium10hydroxy-1,4-naphthoquinonegeroprotector;
herbicide;
reactive oxygen species generator
plumbagin[no description available]medium10hydroxy-1,4-naphthoquinone;
phenols		anticoagulant;
antineoplastic agent;
immunological adjuvant;
metabolite
cobalt[no description available]medium10cobalt group element atom;
metal allergen		micronutrient
isospaglumic acid[no description available]medium10dipeptidehuman metabolite
folic acid[no description available]medium10folic acids;
N-acyl-amino acid		human metabolite;
mouse metabolite;
nutrient
captopril[no description available]medium10alkanethiol;
L-proline derivative;
N-acylpyrrolidine;
pyrrolidinemonocarboxylic acid		antihypertensive agent;
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor
isatoic anhydride[no description available]medium10
histidine[no description available]medium10amino acid zwitterion;
histidine;
L-alpha-amino acid;
polar amino acid zwitterion;
proteinogenic amino acid		algal metabolite;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite
carbamates[no description available]medium10amino-acid anion
thiazolyl blue[no description available]medium10organic bromide saltcolorimetric reagent;
dye
thiazoles[no description available]medium101,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
pyrethrins[no description available]medium10
cypermethrin[no description available]medium10aromatic ether;
cyclopropanecarboxylate ester;
nitrile;
organochlorine compound		agrochemical;
molluscicide;
pyrethroid ester acaricide;
pyrethroid ester insecticide
cyclosporine[no description available]medium10
sirolimus[no description available]medium10antibiotic antifungal drug;
cyclic acetal;
cyclic ketone;
ether;
macrolide lactam;
organic heterotricyclic compound;
secondary alcohol		antibacterial drug;
anticoronaviral agent;
antineoplastic agent;
bacterial metabolite;
geroprotector;
immunosuppressive agent;
mTOR inhibitor
tacrolimus[no description available]medium10macrolide lactambacterial metabolite;
immunosuppressive agent
pyrrolidine dithiocarbamate[no description available]medium10dithiocarbamic acids;
pyrrolidines		anticonvulsant;
antineoplastic agent;
geroprotector;
neuroprotective agent;
NF-kappaB inhibitor;
radical scavenger
p-methoxy-n-methylphenethylamine[no description available]medium10aromatic ether;
secondary amino compound		metabolite
lunularin[no description available]medium10stilbenoid
3,3',4,5'-tetrahydroxystilbene[no description available]medium10catechols;
polyphenol;
resorcinols;
stilbenol		antineoplastic agent;
apoptosis inducer;
geroprotector;
hypoglycemic agent;
plant metabolite;
protein kinase inhibitor;
tyrosine kinase inhibitor
questin[no description available]medium10dihydroxyanthraquinone
tryptophan[no description available]medium10erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid zwitterion;
L-alpha-amino acid;
proteinogenic amino acid;
tryptophan zwitterion;
tryptophan		antidepressant;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
asperflavin[no description available]medium10
tardioxopiperazine a[no description available]medium102,5-diketopiperazines
nitroarginine[no description available]medium10guanidines;
L-arginine derivative;
N-nitro compound;
non-proteinogenic L-alpha-amino acid
cyclic gmp[no description available]medium103',5'-cyclic purine nucleotide;
guanyl ribonucleotide		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite
amyloid beta-peptides[no description available]medium10
amlodipine[no description available]medium10dihydropyridine;
ethyl ester;
methyl ester;
monochlorobenzenes;
primary amino compound		antihypertensive agent;
calcium channel blocker;
vasodilator agent
penicillamine[no description available]medium10non-proteinogenic alpha-amino acid;
penicillamine		antirheumatic drug;
chelator;
copper chelator;
drug allergen
s-nitro-n-acetylpenicillamine[no description available]medium10
puromycin[no description available]medium10puromycinsantiinfective agent;
antimicrobial agent;
antineoplastic agent;
EC 3.4.11.14 (cytosol alanyl aminopeptidase) inhibitor;
EC 3.4.14.2 (dipeptidyl-peptidase II) inhibitor;
nucleoside antibiotic;
protein synthesis inhibitor
1, 3-di-(n-carboxybenzoyl-leucyl-leucyl)amino acetone[no description available]medium10
brefeldin a[no description available]medium10macrolide antibioticPenicillium metabolite
aspartic acid[no description available]medium10aspartate family amino acid;
aspartic acid;
L-alpha-amino acid;
proteinogenic amino acid		Escherichia coli metabolite;
mouse metabolite;
neurotransmitter
acetyl-aspartyl-glutamyl-valyl-aspartal[no description available]medium10tetrapeptideprotease inhibitor
etoposide[no description available]medium10beta-D-glucoside;
furonaphthodioxole;
organic heterotetracyclic compound		antineoplastic agent;
DNA synthesis inhibitor
cytarabine[no description available]medium10beta-D-arabinoside;
monosaccharide derivative;
pyrimidine nucleoside		antimetabolite;
antineoplastic agent;
antiviral agent;
immunosuppressive agent
staurosporine[no description available]medium10ammonium ion derivative
circumdatin f[no description available]medium10
monomethyl succinate[no description available]medium10dicarboxylic acid
ochratoxin b[no description available]medium10isochromanes;
monocarboxylic acid;
N-acyl-L-phenylalanine;
phenylalanine derivative		Aspergillus metabolite;
calcium channel blocker;
mycotoxin;
Penicillium metabolite
endothelin-1[no description available]medium10
glycine[no description available]medium10alpha-amino acid;
amino acid zwitterion;
proteinogenic amino acid;
serine family amino acid		EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor;
fundamental metabolite;
hepatoprotective agent;
micronutrient;
neurotransmitter;
NMDA receptor agonist;
nutraceutical
cathepsin g[no description available]medium10
sivelestat[no description available]medium10N-acylglycine;
pivalate ester
aa 861[no description available]medium101,4-benzoquinones;
acetylenic compound;
primary alcohol		EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor;
ferroptosis inhibitor
tropolone[no description available]medium10alpha-hydroxy ketone;
cyclic ketone;
enol		bacterial metabolite;
fungicide;
toxin
6-methoxybenzoxazolinone[no description available]medium10aromatic ether;
benzoxazole		antibacterial agent;
anticonvulsant;
antifungal agent;
muscle relaxant;
plant metabolite
beta-thujaplicin[no description available]medium10cyclic ketone;
enol;
monoterpenoid		antibacterial agent;
antifungal agent;
antineoplastic agent;
antiplasmodial drug;
plant metabolite
benzoxazoles[no description available]medium101,3-benzoxazoles;
mancude organic heterobicyclic parent
caseins[no description available]medium10
potassium chloride[no description available]medium10inorganic chloride;
inorganic potassium salt;
potassium salt		fertilizer
euscaphic acid[no description available]medium10hydroxy monocarboxylic acid;
pentacyclic triterpenoid;
triol		plant metabolite
hyaluronoglucosaminidase[no description available]medium10
aspirin[no description available]medium10benzoic acids;
phenyl acetates;
salicylates		anticoagulant;
antipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
drug allergen;
EC 1.1.1.188 (prostaglandin-F synthase) inhibitor;
geroprotector;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
plant activator;
platelet aggregation inhibitor;
prostaglandin antagonist;
teratogenic agent
formaldehyde[no description available]medium10aldehyde;
one-carbon compound		allergen;
carcinogenic agent;
disinfectant;
EC 3.5.1.4 (amidase) inhibitor;
environmental contaminant;
Escherichia coli metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
sabinene[no description available]medium10thujeneplant metabolite
isomethyleugenol[no description available]medium40isomethyleugenol
fusarium[no description available]medium50
trazodone hydrochloride[no description available]medium20hydrochlorideadrenergic antagonist;
antidepressant;
H1-receptor antagonist;
sedative;
serotonin uptake inhibitor
hypericum[no description available]medium20penicillanic acids
nsc 4347[no description available]medium10
ants[no description available]medium10
trolamine salicylate[no description available]medium30
7-amino-4-chloro-3-methoxy-2-benzopyran-1-one[no description available]low00isocoumarins
coriandrin[no description available]low00isocoumarins
1-oxo-N-(3-pyridinyl)-2-benzopyran-4-carboxamide[no description available]low00isocoumarins
ConditionIndicatedRelationship StrengthStudiesTrials
Abnormalities, Autosome0low20
Abnormalities, Chromosomal0low20
Abnormalities, Chromosome0low20
Acute Brain Injuries0low10
Acute Confusional Senile Dementia0low20
Acute Hepatic Failure0low10
Acute Liver Failure0low10
Acute Myelogenous Leukemia0low10
Acute Myeloid Leukemia0low10
Acute Myeloid Leukemia with Maturation0low10
Acute Myeloid Leukemia without Maturation0low10
Adenocarcinoma0low30
Adenocarcinoma, Basal Cell0low30
Adenocarcinoma, Granular Cell0low30
Adenocarcinoma, Oxyphilic0low30
Adenocarcinoma, Tubular0low30
Adenoma, Malignant0low30
Adjuvant Arthritis0low20
Adult Spinal Muscular Atrophy0low40
Adult-Onset Spinal Muscular Atrophy0low40
African Lymphoma0low20
Allergic Contact Dermatitis0low10
Alloxan Diabetes0low10
Alzheimer Dementia0low20
Alzheimer Disease0low20
Alzheimer Disease, Early Onset0low20
Alzheimer Disease, Late Onset0low20
Alzheimer Sclerosis0low20
Alzheimer Syndrome0low20
Alzheimer Type Senile Dementia0low20
Alzheimer-Type Dementia (ATD)0low20
Alzheimer's Disease0low20
Alzheimer's Disease, Focal Onset0low20
Alzheimer's Diseases0low20
Amyotrophy, Neurogenic Scapuloperoneal, New England Type0low40
Anasarca0low10
Angiogenesis, Pathologic0low40
Angiogenesis, Pathological0low40
ANLL0low10
Arteriosclerosis0low10
Arthritis0low30
Arthritis, Adjuvant0low20
Arthritis, Adjuvant-Induced0low20
Arthritis, Collagen-Induced0low20
Arthritis, Experimental0low20
Atopic Hypersensitivity0low10
Atypical Lipomatous Tumor0low10
Autosomal Dominant Juvenile Parkinson Disease0low10
Autosomal Dominant Juvenile Parkinsonism0low10
Autosomal Dominant Parkinsonism0low10
Autosomal Recessive Juvenile Parkinson Disease0low10
Autosomal Recessive Juvenile Parkinsonism0low10
Autosomal Recessive Parkinsonism0low10
Autosome Abnormalities0low20
B-Cell Leukemia0low10
B-Lymphocytic Leukemia0low10
B16 Melanoma0low20
Babesia Infection0low10
Babesia Parasite Infection0low10
Babesiasis0low10
Babesiosis0low10
Benign Neoplasms0low70
Blunt Injuries0low10
Body Weight0low10
Brain Injuries0low10
Brain Injuries, Acute0low10
Brain Injuries, Focal0low10
Brain Lacerations0low10
Breast Cancer0low40
Breast Carcinoma0low40
Breast Neoplasms0low40
Breast Tumors0low40
Bulbospinal Neuronopathy0low40
Burkitt Cell Leukemia0low20
Burkitt Leukemia0low20
Burkitt Lymphoma0low20
Burkitt Tumor0low20
Burkitt's Leukemia0low20
Burkitt's Lymphoma0low20
Burkitt's Tumor0low20
Cancer0low70
Cancer of Breast0low40
Cancer of Colon0low20
Cancer of Endometrium0low10
Cancer of Esophagus0low10
Cancer of Intestines0low10
Cancer of Liver0low20
Cancer of Lung0low50
Cancer of Nasopharynx0low10
Cancer of Ovary0low10
Cancer of Pancreas0low10
Cancer of Prostate0low20
Cancer of Skin0low20
Cancer of Stomach0low60
Cancer of the Breast0low40
Cancer of the Colon0low20
Cancer of the Endometrium0low10
Cancer of the Esophagus0low10
Cancer of the Intestines0low10
Cancer of the Liver0low20
Cancer of the Lung0low50
Cancer of the Nasopharynx0low10
Cancer of the Ovary0low10
Cancer of the Pancreas0low10
Cancer of the Prostate0low20
Cancer of the Skin0low20
Cancer of the Stomach0low60
Cancer, Hepatocellular0low20
Carcinoma of Endometrium0low10
Carcinoma, Cribriform0low30
Carcinoma, Ehrlich Tumor0low20
Carcinoma, Epidermoid0low10
Carcinoma, Granular Cell0low30
Carcinoma, Hepatocellular0low20
Carcinoma, Lewis Lung0low20
Carcinoma, Non-Small Cell Lung0low10
Carcinoma, Non-Small-Cell Lung0low10
Carcinoma, Planocellular0low10
Carcinoma, Squamous0low10
Carcinoma, Squamous Cell0low10
Carcinoma, Tubular0low30
Cardiac Failure0low10
Catheter-Associated Infections0medium11
Catheter-Related Infections0medium11
Chromosomal Aberrations0low20
Chromosome 6-Linked Autosomal Recessive Parkinsonism0low10
Chromosome Aberrations0low20
Chromosome Abnormalities0low20
Chronic Disease0low10
Chronic Illness0low10
Chronically Ill0low10
Cirrhosis, Liver0low20
Collagen Arthritis0low20
Colon Cancer0low20
Colon Neoplasms0low20
Colonic Cancer0low20
Colonic Neoplasms0low20
Complication, Postoperative0low10
Congestive Heart Failure0low10
Contact Dermatitis0low20
Cross Infection0medium11
Cytogenetic Aberrations0low20
Cytogenetic Abnormalities0low20
Delayed Hypersensitivity0low10
Dementia, Alzheimer Type0low20
Dementia, Presenile0low20
Dementia, Primary Senile Degenerative0low20
Dementia, Senile0low20
Dermatitis Venenata0low20
Dermatitis, Allergic Contact0low10
Dermatitis, Allergic Eczematous0low10
Dermatitis, Contact0low20
Dermatitis, Contact, Allergic0low10
Dermatitis, Eczematous0low10
Dermatitis, Irritant0low10
Dermatitis, Occupational0low10
Dermatitis, Primary Irritant0low10
Dermatosis, Industrial0low10
Diabetes Mellitus, Adult-Onset0low20
Diabetes Mellitus, Experimental0low10
Diabetes Mellitus, Ketosis-Resistant0low20
Diabetes Mellitus, Maturity-Onset0low20
Diabetes Mellitus, Non Insulin Dependent0low20
Diabetes Mellitus, Non-Insulin-Dependent0low20
Diabetes Mellitus, Noninsulin Dependent0low20
Diabetes Mellitus, Noninsulin-Dependent0low20
Diabetes Mellitus, Slow-Onset0low20
Diabetes Mellitus, Stable0low20
Diabetes Mellitus, Type 20low20
Diabetes Mellitus, Type II0low20
Diabetic Glomerulosclerosis0low10
Diabetic Kidney Disease0low10
Diabetic Nephropathies0low10
Diabetic Nephropathy0low10
Disease Models, Animal0low60
Distal Spinal Muscular Atrophy0low40
Dropsy0low10
Early Onset Alzheimer Disease0low20
Eczema0low10
Eczema, Contact0low20
Edema0low10
Ehrlich Ascites Tumor0low20
Endometrial Cancer0low10
Endometrial Carcinoma0low10
Endometrial Neoplasms0low10
Endometrium Cancer0low10
Esophageal Cancer0low10
Esophageal Neoplasms0low10
Esophagus Cancer0low10
Esophagus Neoplasm0low10
Experimental Diabetes Mellitus0low10
Experimental Melanoma0low20
Experimental Melanomas0low20
Experimental Neoplasms0low40
Experimental Parkinson Disease0low10
Experimental Parkinsonism0low10
Experimental Parkinsonism, MPTP-Induced0low10
Extravascular Hemolysis0low20
Factitious Disorders0low10
Familial Alzheimer Disease (FAD)0low20
Familial Juvenile Parkinsonism0low10
Familial Parkinson Disease, Autosomal Recessive0low10
Fibrosis, Liver0low20
Focal Brain Injuries0low10
Focal Onset Alzheimer's Disease0low20
Fulminant Hepatic Failure0low10
Fulminating Hepatic Failure0low10
Fulminating Liver Failure0low10
Ganser Syndrome0low10
Gastric Cancer0low60
Gastric Cancer, Familial Diffuse0low60
Gastric Neoplasms0low60
Gastric Ulcer0low20
Gastroduodenal Ulcer0low10
Glomerulosclerosis, Diabetic0low10
Haemolysis0low20
Hand Dermatoses0low10
Hand Dermatosis0low10
Harding Passey Melanoma0low20
Health Care Associated Infection0medium11
Health Care Associated Infections0medium11
Healthcare Associated Infections0medium11
Heart Decompensation0low10
Heart Failure0low10
Heart Failure, Congestive0low10
Heart Failure, Left-Sided0low10
Heart Failure, Right-Sided0low10
Helicobacter Infections0low10
Hemolysis0low20
Hepatic Cancer0low20
Hepatic Cirrhosis0low20
Hepatic Failure, Acute0low10
Hepatic Failure, Fulminant0low10
Hepatic Neoplasms0low20
Hepatocellular Cancer0low20
Hepatocellular Carcinoma0low20
Hepatoma0low20
Hereditary Motor Neuronopathy0low40
Hospital Infections0medium11
Human Babesiosis0low10
Human Mammary Carcinoma0low40
Hydrops0low10
Hypersensitivity, Atopic0low10
Hypersensitivity, Contact0low20
Hypersensitivity, Delayed0low10
Hypersensitivity, Immediate0low10
Hypersensitivity, Tuberculin-Type0low10
Hypersensitivity, Type I0low10
Hypersensitivity, Type III0low10
Hypersensitivity, Type IV0low10
IgE-Mediated Hypersensitivity0low10
Immune Complex Diseases0low10
Industrial Dermatosis0low10
Infection, Cross0medium11
Infection, Postoperative Wound0medium11
Infection, Surgical Wound0medium11
Infections, Helicobacter0low10
Infections, Hospital0medium11
Infections, Nosocomial0medium11
Infections, Plasmodium0low20
Inflammation0low60
Injuries, Acute Brain0low10
Injuries, Blunt0low10
Injuries, Brain0low10
Injuries, Nonpenetrating0low10
Innate Inflammatory Response0low60
Intestinal Cancer0low10
Intestinal Neoplasms0low10
Intestines Cancer0low10
Intestines Neoplasms0low10
Intracapillary Glomerulosclerosis0low10
Intravascular Hemolysis0low20
Irritant Dermatitis0low10
Juvenile Parkinson Disease0low10
Juvenile Parkinson Disease, Autosomal Dominant0low10
Juvenile Parkinson Disease, Autosomal Recessive0low10
Juvenile Parkinsonism, Autosomal Dominant0low10
Juvenile Parkinsonism, Autosomal Recessive0low10
Kahler Disease0low20
Kimmelstiel-Wilson Disease0low10
Kimmelstiel-Wilson Syndrome0low10
Late Onset Alzheimer Disease0low20
Left-Sided Heart Failure0low10
Leishmania Infection0low10
Leishmaniasis0low10
Leukemia, Acute Myelogenous0low10
Leukemia, Acute Myeloid0low10
Leukemia, B-Cell0low10
Leukemia, Lymphoblastic, Burkitt-Type0low20
Leukemia, Lymphocytic, B Cell0low10
Leukemia, Lymphocytic, B-Cell0low10
Leukemia, Lymphocytic, L30low20
Leukemia, Myeloblastic, Acute0low10
Leukemia, Myelocytic, Acute0low10
Leukemia, Myelogenous, Acute0low10
Leukemia, Myeloid, Acute0low10
Leukemia, Myeloid, Acute, M10low10
Leukemia, Myeloid, Acute, M20low10
Leukemia, Nonlymphoblastic, Acute0low10
Leukemia, Nonlymphocytic, Acute0low10
Liposarcoma0low10
Liposarcoma, Dedifferentiated0low10
Liposarcoma, Pleomorphic0low10
Liposarcoma, Well Differentiated0low10
Liver Cancer0low20
Liver Cancer, Adult0low20
Liver Cell Carcinoma0low20
Liver Cell Carcinoma, Adult0low20
Liver Cirrhosis0low20
Liver Failure, Acute0low10
Liver Failure, Fulminant0low10
Liver Fibrosis0low20
Liver Neoplasms0low20
Lung Cancer0low50
Lung Neoplasms0low50
Lymphocytic Leukemia, B-Cell0low10
Lymphocytic Leukemia, L30low20
Lymphoma, Burkitt0low20
Malaria0low20
Malaria, Falciparum0low40
Malignancy0low70
Malignant Melanoma0low20
Malignant Neoplasm of Breast0low40
Malignant Neoplasms0low70
Malignant Tumor of Breast0low40
Mammary Cancer0low40
Mammary Carcinoma, Human0low40
Mammary Neoplasm, Human0low40
Mammary Neoplasms, Human0low40
Marginal Ulcer0low10
Marsh Fever0low20
Mast-Cell Sarcoma0low10
Mastocytoma, Malignant0low10
Maturity-Onset Diabetes0low20
Maturity-Onset Diabetes Mellitus0low20
Melanoma0low20
Melanoma, B160low20
Melanoma, Cloudman S910low20
Melanoma, Experimental0low20
Melanoma, Harding-Passey0low20
Melanomas, Experimental0low20
Metastase0low10
Metastases, Neoplasm0low10
Metastasis0low10
Metastasis, Neoplasm0low10
MODY0low20
MPTP-Induced Experimental Parkinsonism0low10
Multiple Myeloma0low20
Muscular Atrophy, Adult Spinal0low40
Muscular Atrophy, Spinal0low40
Myeloblastic Leukemia, Acute0low10
Myelocytic Leukemia, Acute0low10
Myelogenous Leukemia, Acute0low10
Myeloid Leukemia, Acute0low10
Myeloid Leukemia, Acute, M10low10
Myeloid Leukemia, Acute, M20low10
Myeloma-Multiple0low20
Myeloma, Multiple0low20
Myeloma, Plasma-Cell0low20
Myelomatosis0low20
Myelopathic Muscular Atrophy0low40
Myelopathic Muscular Atrophy, Progressive0low40
Myocardial Failure0low10
Nasopharyngeal Cancer0low10
Nasopharyngeal Carcinoma0low10
Nasopharyngeal Neoplasms0low10
Nasopharynx Cancer0low10
Nasopharynx Neoplasms0low10
Necrosis0low20
Neoplasia0low70
Neoplasm0low70
Neoplasm Metastases0low10
Neoplasm Metastasis0low10
Neoplasms0low70
Neoplasms, Benign0low70
Neoplasms, Breast0low40
Neoplasms, Colonic0low20
Neoplasms, Endometrial0low10
Neoplasms, Esophageal0low10
Neoplasms, Experimental0low40
Neoplasms, Gastric0low60
Neoplasms, Hepatic0low20
Neoplasms, Intestinal0low10
Neoplasms, Liver0low20
Neoplasms, Lung0low50
Neoplasms, Nasopharyngeal0low10
Neoplasms, Ovarian0low10
Neoplasms, Pancreatic0low10
Neoplasms, Prostate0low20
Neoplasms, Prostatic0low20
Neoplasms, Pulmonary0low50
Neoplasms, Skin0low20
Neoplasms, Stomach0low60
Neovascularization, Pathologic0low40
Neovascularization, Pathological0low40
Neuroblastoma0low20
NIDDM0low20
Nodular Glomerulosclerosis0low10
Non-Small Cell Lung Cancer0low10
Non-Small Cell Lung Carcinoma0low10
Non-Small-Cell Lung Carcinoma0low10
Noninsulin-Dependent Diabetes Mellitus0low20
Nonlymphoblastic Leukemia, Acute0low10
Nonlymphocytic Leukemia, Acute0low10
Nonpenetrating Injuries0low10
Nonsmall Cell Lung Cancer0low10
Nosocomial Infections0medium11
Obesity0low10
Occupational Dermatitis0low10
Oculopharyngeal Spinal Muscular Atrophy0low40
Ovarian Cancer0low10
Ovarian Neoplasms0low10
Ovary Cancer0low10
Ovary Neoplasms0low10
Paludism0low20
Pancreas Cancer0low10
Pancreas Neoplasms0low10
Pancreatic Cancer0low10
Pancreatic Neoplasms0low10
Parkinson Disease 20low10
Parkinson Disease 2, Autosomal Recessive Juvenile0low10
Parkinson Disease Autosomal Recessive, Early Onset0low10
Parkinson Disease, Autosomal Dominant. Juvenile0low10
Parkinson Disease, Experimental0low10
Parkinson Disease, Familial, Autosomal Recessive0low10
Parkinson Disease, Juvenile0low10
Parkinson Disease, Juvenile, Autosomal Dominant0low10
Parkinson Disease, Juvenile, Autosomal Recessive0low10
Parkinsonian Diseases0low10
Parkinsonian Disorders0low10
Parkinsonian Syndrome0low10
Parkinsonian Syndromes0low10
Parkinsonism0low10
Parkinsonism, Early Onset, with Diurnal Fluctuation0low10
Parkinsonism, Early-Onset, With Diurnal Fluctuation0low10
Parkinsonism, Experimental0low10
Parkinsonism, Juvenile0low10
Parkinsonism, Juvenile, Autosomal Dominant0low10
Parkinsonism, Juvenile, Autosomal Recessive0low10
Pathologic Angiogenesis0low40
Pathologic Neovascularization0low40
Peptic Ulcer0low10
Piroplasmosis0low10
Plasma Cell Myeloma0low20
Plasmodium falciparum Malaria0low40
Plasmodium Infections0low20
Pneumonia, Ventilator-Associated0medium11
Polyarthritis0low30
Postoperative Complications0low10
Postoperative Wound Infection0medium11
Presenile Alzheimer Dementia0low20
Primary Senile Degenerative Dementia0low20
Progressive Muscular Atrophy0low40
Progressive Myelopathic Muscular Atrophy0low40
Progressive Proximal Myelopathic Muscular Atrophy0low40
Prostate Cancer0low20
Prostate Neoplasms0low20
Prostatic Cancer0low20
Prostatic Neoplasms0low20
Proximal Myelopathic Muscular Atrophy, Progressive0low40
Pseudodementia0low10
Pseudopsychosis0low10
Pulmonary Cancer0low50
Pulmonary Neoplasms0low50
Ramsay Hunt Paralysis Syndrome0low10
Remittent Fever0low20
Right-Sided Heart Failure0low10
Sarcoma 1800low10
Sarcoma 180, Crocker0low10
Sarcoma, Mast-Cell0low10
Scapuloperoneal Form of Spinal Muscular Atrophy0low40
Scapuloperoneal Spinal Muscular Atrophy0low40
Senile Dementia, Acute Confusional0low20
Senile Dementia, Alzheimer Type0low20
Sensitivity and Specificity0low10
Sensitivity, Contact0low20
Skin Aging0low10
Skin Cancer0low20
Skin Neoplasms0low20
Spinal Amyotrophy0low40
Spinal Muscular Atrophy0low40
Spinal Muscular Atrophy, Distal0low40
Spinal Muscular Atrophy, Oculopharyngeal0low40
Spinal Muscular Atrophy, Scapuloperoneal0low40
Spinal Muscular Atrophy, Scapuloperoneal Form0low40
Squamous Cell Carcinoma0low10
Stomach Cancer0low60
Stomach Neoplasms0low60
Stomach Ulcer0low20
Streptozocin Diabetes0low10
Streptozotocin Diabetes0low10
Surgical Site Infection0medium11
Surgical Wound Infection0medium11
Tuberculin-Type Hypersensitivity0low10
Tumors0low70
Tumors, Breast0low40
Type 2 Diabetes0low20
Type 2 Diabetes Mellitus0low20
Type I Hypersensitivity0low10
Type III Hypersensitivity0low10
Type IV Hypersensitivity0low10
Ventilator-Associated Pneumonia0medium11
Well Differentiated Liposarcoma0low10
Wound Infection, Postoperative0medium11
Wound Infection, Surgical0medium11
Wounds, Nonpenetrating0low10

Research Highlights

Safety/Toxicity (6)

ArticleYear
New isocoumarins from a cold-adapted fungal strain mucor sp. and their developmental toxicity to zebrafish embryos.
Chemistry & biodiversity, Volume: 11, Issue: 7		2014
Topoisomerase I inactivation by reticulol and its in vivo cytotoxicity against B16F10 melanoma.
Chemotherapy, Volume: 49, Issue: 5		2003
NM-3, an isocoumarin, increases the antitumor effects of radiotherapy without toxicity.
Cancer research, Dec-15, Volume: 60, Issue: 24		2000
Acute myeloblastic leukemic cells acquire cellular cytotoxicity under genotoxic stress: implication of granzyme B and perforin.
Blood, Sep-01, Volume: 96, Issue: 5		2000
Differences in neurotoxic effects of ochratoxin A, ochracin and ochratoxin-alpha in vitro.
Natural toxins, Volume: 6, Issue: 5		1998
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Pharmacokinetics (1)

ArticleYear
Pharmacokinetics, pharmacodynamics, and efficacy of a small-molecule SMN2 splicing modifier in mouse models of spinal muscular atrophy.
Human molecular genetics, 05-15, Volume: 25, Issue: 10		2016
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioavailability (4)

ArticleYear
Design and Synthesis of Metabolically Stable tRNA Synthetase Inhibitors Derived from Cladosporin.
Chembiochem : a European journal of chemical biology, 03-01, Volume: 20, Issue: 5		2019
The angiogenesis inhibitor NM-3 is active against human NSCLC xenografts alone and in combination with docetaxel.
Cancer chemotherapy and pharmacology, Volume: 56, Issue: 6		2005
2-(8-Hydroxy-6-methoxy-1-oxo-1H-2-benzopyran-3-yl)propionic acid, a small molecule isocoumarin, potentiates dexamethasone-induced apoptosis of human multiple myeloma cells.
Cancer research, Dec-01, Volume: 64, Issue: 23		2004
NM-3, an isocoumarin, increases the antitumor effects of radiotherapy without toxicity.
Cancer research, Dec-15, Volume: 60, Issue: 24		2000
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Dosage (5)

ArticleYear
Pyruvate dehydrogenase complex and lactate dehydrogenase are targets for therapy of acute liver failure.
Journal of hepatology, Volume: 69, Issue: 2		2018
Hydrangenol inhibits lipopolysaccharide-induced nitric oxide production in BV2 microglial cells by suppressing the NF-κB pathway and activating the Nrf2-mediated HO-1 pathway.
International immunopharmacology, Volume: 35		2016
Hypervalent Iodine-Mediated Intramolecular trans-Aminocarboxylation and Oxoaminocarboxylation of Alkynes: Divergent Cascade Annulations of Isocoumarins under Metal-Free Conditions.
Organic letters, Nov-06, Volume: 17, Issue: 21		2015
1H-2-Benzopyran-1-one derivatives, microbial products with pharmacological activity. Conversion into orally active derivatives with antiinflammatory and antiulcer activities.
Journal of medicinal chemistry, Volume: 28, Issue: 1		1985
Ulcerogenic and antiulcerogenic effects of a new antiinflammatory drug, the gamma-lactone-N-ethyl derivative of 6-[1S-(3S,4-dihydro-8-hydroxy-1H-2-benzo- pyran-1-one-3-yl)-3-methylbutylamino]-4S,5S-dihydroxy-6-oxo-3S- ammoniohexanoate, on gastrointestinal
Arzneimittel-Forschung, Volume: 36, Issue: 9		1986
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Interactions (3)

ArticleYear
Constituents of Fagraea fragrans with Antimycobacterial Activity in Combination with Erythromycin.
Journal of natural products, Apr-22, Volume: 79, Issue: 4		2016
Effect of 2-(8-hydroxy-6-methoxy-1-oxo-1H-2-benzopyran-3-yl) propionic acid in combination with carboplatin on gastric carcinoma growth in vivo.
World journal of gastroenterology, Jan-28, Volume: 13, Issue: 4		2007
The angiogenesis inhibitor NM-3 is active against human NSCLC xenografts alone and in combination with docetaxel.
Cancer chemotherapy and pharmacology, Volume: 56, Issue: 6		2005
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Natural Sources (2)

ArticleYear
Acylphloroglucinolated Catechin and Phenylethyl Isocoumarin Derivatives from Agrimonia pilosa.
Journal of natural products, 09-23, Volume: 79, Issue: 9		2016
[Studies on metabolites from marine microorganism Aspergillus terreus collected from nature reserve region of mangrove].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, Volume: 36, Issue: 18		2011
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]