acetaldehyde has been researched along with Necrosis in 15 studies
Acetaldehyde: A colorless, flammable liquid used in the manufacture of acetic acid, perfumes, and flavors. It is also an intermediate in the metabolism of alcohol. It has a general narcotic action and also causes irritation of mucous membranes. Large doses may cause death from respiratory paralysis.
acetaldehyde : The aldehyde formed from acetic acid by reduction of the carboxy group. It is the most abundant carcinogen in tobacco smoke.
aldehyde : A compound RC(=O)H, in which a carbonyl group is bonded to one hydrogen atom and to one R group.
acetyl group : A group, formally derived from acetic acid by dehydroxylation, which is fundamental to the biochemistry of all forms of life. When bound to coenzyme A, it is central to the metabolism of carbohydrates and fats.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Flow cytometric analyses by means of annexin-V and propidium iodide double staining and immunofluorescence staining of active caspase-3 revealed that cells subjected to a lethal dose of chloroacetaldehyde displayed features characteristic of necrosis and that caspase-3 was not activated in response to chloroacetaldehyde." | 7.74 | Necrotic pathway in human osteosarcoma Saos-2 cell death induced by chloroacetaldehyde. ( Fujimoto, Y; Sakurai, K; Takahashi, K; Tanaka, H, 2007) |
| "Since necrosis has been implicated in enhancing both primary and secondary immune responses, and necrosis was predominantly occurring in response to MAA-haptenated proteins, a possible mechanism by which the immunogenicity of MAA modification of proteins in vivo may occur is suggested." | 5.31 | Malondialdehyde-acetaldehyde-haptenated protein induces cell death by induction of necrosis and apoptosis in immune cells. ( Klassen, LW; Thiele, GM; Tuma, DJ; Willis, MS, 2002) |
| " Flow cytometric analyses by means of annexin-V and propidium iodide double staining and immunofluorescence staining of active caspase-3 revealed that cells subjected to a lethal dose of chloroacetaldehyde displayed features characteristic of necrosis and that caspase-3 was not activated in response to chloroacetaldehyde." | 3.74 | Necrotic pathway in human osteosarcoma Saos-2 cell death induced by chloroacetaldehyde. ( Fujimoto, Y; Sakurai, K; Takahashi, K; Tanaka, H, 2007) |
| "Chloroacetaldehyde (CAA) is a metabolite of the alkylating agent ifosfamide (IFO) and putatively responsible for renal damage following anti-tumor therapy with IFO." | 1.33 | Chloroacetaldehyde as a sulfhydryl reagent: the role of critical thiol groups in ifosfamide nephropathy. ( Benesic, A; Freudinger, R; Gekle, M; Groezinger, F; Kirchhoff, A; Mildenberger, S; Schwerdt, G; Wollny, B, 2006) |
| "Since necrosis has been implicated in enhancing both primary and secondary immune responses, and necrosis was predominantly occurring in response to MAA-haptenated proteins, a possible mechanism by which the immunogenicity of MAA modification of proteins in vivo may occur is suggested." | 1.31 | Malondialdehyde-acetaldehyde-haptenated protein induces cell death by induction of necrosis and apoptosis in immune cells. ( Klassen, LW; Thiele, GM; Tuma, DJ; Willis, MS, 2002) |
| "No acetaldehyde adduct was detected in the control rats that were pair-fed with isocaloric amounts of dextrose." | 1.30 | Acetaldehyde-modified and 4-hydroxynonenal-modified proteins in the livers of rats with alcoholic liver disease. ( Li, CJ; Lin, RC; Nanji, AA; Siakotos, AN, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (33.33) | 18.7374 |
| 1990's | 2 (13.33) | 18.2507 |
| 2000's | 5 (33.33) | 29.6817 |
| 2010's | 3 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Luo, Z | 1 |
| Liu, H | 1 |
| Sun, X | 1 |
| Guo, R | 1 |
| Cui, R | 1 |
| Ma, X | 1 |
| Yan, M | 1 |
| Kayani, MA | 1 |
| Parry, JM | 1 |
| Nukada, Y | 1 |
| Ito, Y | 1 |
| Miyazawa, M | 1 |
| Sakaguchi, H | 1 |
| Nishiyama, N | 1 |
| Duryee, MJ | 1 |
| Willis, MS | 2 |
| Freeman, TL | 1 |
| Kuszynski, CA | 1 |
| Tuma, DJ | 2 |
| Klassen, LW | 2 |
| Thiele, GM | 2 |
| Benesic, A | 2 |
| Schwerdt, G | 2 |
| Freudinger, R | 2 |
| Mildenberger, S | 1 |
| Groezinger, F | 1 |
| Wollny, B | 2 |
| Kirchhoff, A | 2 |
| Gekle, M | 2 |
| Takahashi, K | 2 |
| Sakurai, K | 1 |
| Tanaka, H | 1 |
| Fujimoto, Y | 1 |
| Zabirova, IG | 2 |
| Lieber, CS | 1 |
| Nuzhnyĭ, VP | 1 |
| Uspenskiĭ, AE | 1 |
| Niemelä, O | 1 |
| Parkkila, S | 1 |
| Ylä-Herttuala, S | 1 |
| Villanueva, J | 1 |
| Ruebner, B | 1 |
| Halsted, CH | 1 |
| Li, CJ | 1 |
| Nanji, AA | 1 |
| Siakotos, AN | 1 |
| Lin, RC | 1 |
| Moura, D | 1 |
| Azevedo, I | 1 |
| Osswald, W | 1 |
| Actis, GC | 1 |
| Ponzetto, A | 1 |
| Rizzetto, M | 1 |
| Verme, G | 1 |
2 reviews available for acetaldehyde and Necrosis
| Article | Year |
|---|---|
Mechanisms of alcohol liver damage: aldehydes, scavenger receptors, and autoimmunity.
Topics: Acetaldehyde; Aldehydes; Animals; Apoptosis; Autoimmune Diseases; Autoimmunity; CD4-Positive T-Lymph | 2004 |
Metabolism and metabolic effects of ethanol.
Topics: Acetaldehyde; Alcoholic Beverages; Carbohydrate Metabolism; Collagen; Ethanol; Fatty Liver, Alcoholi | 1981 |
13 other studies available for acetaldehyde and Necrosis
| Article | Year |
|---|---|
RNA interference against discoidin domain receptor 2 ameliorates alcoholic liver disease in rats.
Topics: Acetaldehyde; Animals; Apoptosis; Cell Line; Cell Proliferation; Collagen Type I; Discoidin Domain R | 2013 |
The in vitro genotoxicity of ethanol and acetaldehyde.
Topics: Acetaldehyde; Aneuploidy; Apoptosis; Cell Line; Cell Proliferation; Cell Survival; Central Nervous S | 2010 |
The relationship between CD86 and CD54 protein expression and cytotoxicity following stimulation with contact allergen in THP-1 cells.
Topics: Acetaldehyde; Allergens; Amino Acid Chloromethyl Ketones; Apoptosis; B7-2 Antigen; Caspase Inhibitor | 2011 |
Chloroacetaldehyde as a sulfhydryl reagent: the role of critical thiol groups in ifosfamide nephropathy.
Topics: Acetaldehyde; Antineoplastic Agents, Alkylating; Biomarkers; Caspase 3; Caspase 8; Cathepsin B; Cell | 2006 |
Mesna or cysteine prevents chloroacetaldehyde-induced cell death of human proximal tubule cells.
Topics: Acetaldehyde; Apoptosis; Cell Line; Cysteine; Dose-Response Relationship, Drug; Drug Antagonism; Dru | 2007 |
Necrotic pathway in human osteosarcoma Saos-2 cell death induced by chloroacetaldehyde.
Topics: Acetaldehyde; Adenosine Triphosphate; Annexin A5; Antineoplastic Agents, Alkylating; Blotting, Weste | 2007 |
[Cardionecrotic effect of ethanol, acetaldehyde and teturam in acute experiments on rats].
Topics: Acetaldehyde; Acute Disease; Animals; Disulfiram; Endomyocardial Fibrosis; Ethanol; Male; Myocardium | 1983 |
[Catecholamines in the mechanism of the cardionecrotic action of acetaldehyde].
Topics: Acetaldehyde; Animals; Catecholamines; Drug Synergism; Epinephrine; Heart; In Vitro Techniques; Levo | 1982 |
Sequential acetaldehyde production, lipid peroxidation, and fibrogenesis in micropig model of alcohol-induced liver disease.
Topics: Acetaldehyde; Aldehydes; Animals; Guinea Pigs; Immunohistochemistry; Lipid Peroxidation; Liver; Live | 1995 |
Acetaldehyde-modified and 4-hydroxynonenal-modified proteins in the livers of rats with alcoholic liver disease.
Topics: Acetaldehyde; Aldehydes; Animals; Antibodies; Corn Oil; Dietary Fats; Fatty Liver; Fish Oils; Humans | 1997 |
Malondialdehyde-acetaldehyde-haptenated protein induces cell death by induction of necrosis and apoptosis in immune cells.
Topics: Acetaldehyde; Animals; Annexin A5; Apoptosis; B-Lymphocytes; DNA Fragmentation; Female; Flow Cytomet | 2002 |
Hepatotoxicity of the condensation product of adrenaline with acetaldehyde.
Topics: Acetaldehyde; Animals; Chemical and Drug Induced Liver Injury; Epinephrine; Liver; Liver Diseases; M | 1977 |
Cell-mediated immunity to acetaldehyde in alcoholic liver disease demonstrated by leukocyte migration test.
Topics: Acetaldehyde; Adult; Aged; Cell Migration Inhibition; Diagnosis, Differential; Female; Hepatitis, Al | 1978 |