A pancreatic triacylglycerol lipase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P16233]
PL;
PTL;
Pancreatic lipase;
EC 3.1.1.3
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| salvin | Homo sapiens (human) | IC50 | 36.0000 | 1 | 1 |
| Koenimbine | Homo sapiens (human) | IC50 | 168.6000 | 1 | 1 |
| mahanimbine | Homo sapiens (human) | IC50 | 17.9000 | 1 | 1 |
| carnosol | Homo sapiens (human) | IC50 | 13.0000 | 1 | 1 |
| orlistat | Homo sapiens (human) | IC50 | 0.3253 | 3 | 3 |
This protein enables 4 target(s):
| Target | Category | Definition |
|---|---|---|
| triglyceride lipase activity | molecular function | Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate. [EC:3.1.1.3] |
| lipase activity | molecular function | Catalysis of the hydrolysis of a lipid or phospholipid. [GOC:mah, ISBN:0198506732] |
| metal ion binding | molecular function | Binding to a metal ion. [GOC:ai] |
| all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity | molecular function | Catalysis of the reaction: all-trans-retinyl palmitate + H2O = all-trans-retinol + H+ + palmitate. [RHEA:13933] |
This protein is located in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| extracellular region | cellular component | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators] |
| extracellular space | cellular component | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| extracellular space | cellular component | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684] |
This protein is involved in 5 target(s):
| Target | Category | Definition |
|---|---|---|
| lipid metabolic process | biological process | The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. [GOC:ma] |
| intestinal cholesterol absorption | biological process | Uptake of cholesterol into the blood by absorption from the small intestine. [GOC:mah] |
| retinol metabolic process | biological process | The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A. [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html, PMID:1924551] |
| positive regulation of triglyceride lipase activity | biological process | Any process that increases the activity of triglyceride lipase. [GOC:dph] |
| lipid catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. [GOC:go_curators] |